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Results for RGT1

Z-value: 2.31

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Transcription factors associated with RGT1

Gene Symbol Gene ID Gene Info
RGT1
S000001521 Glucose-responsive transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RGT1YKL038W-0.991.5e-20Click!

Activity profile of RGT1 motif

Sorted Z-values of RGT1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YFR055W 74.89
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YFR056C 67.27 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YHR094C 52.07
HXT1
Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YKR075C 34.26 Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YDR345C 31.80
HXT3
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YLR154C 24.95
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YGL209W 21.29
MIG2
Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter
YDR033W 20.23
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YLR154W-B 19.83 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YLR154W-A 19.03 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YFR054C 18.65 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YAL038W 17.57
CDC19
Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration
YGR108W 16.68
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YOR051C 13.76 Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
YMR011W 13.39
HXT2
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YMR001C-A 12.69 Putative protein of unknown function
YLL045C 12.02
RPL8B
Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits
YDR098C 11.75
GRX3
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YLR154W-C 11.66
TAR1
Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YDR279W 11.07
RNH202
Ribonuclease H2 subunit, required for RNase H2 activity
YNL178W 10.92
RPS3
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YOR376W-A 10.74 Putative protein of unknown function; identified by fungal homology and RT-PCR
YBL085W 10.69
BOI1
Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
YOR096W 10.54
RPS7A
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
YGL158W 10.36
RCK1
Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations
YGR052W 9.90
FMP48
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
YKL182W 9.88
FAS1
Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
YDL047W 9.60
SIT4
Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
YOR029W 9.56 Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YMR290C 9.52
HAS1
ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YGR138C 9.47
TPO2
Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
YKR038C 9.26
KAE1
Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex
YMR290W-A 9.18 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YIR021W 9.08
MRS1
Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YBR092C 8.87
PHO3
Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin
YKR074W 8.61
AIM29
Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YGR242W 8.57 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
YEL053W-A 8.42 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YEL054C
YOR375C 8.29
GDH1
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources
YHR128W 8.15
FUR1
Uracil phosphoribosyltransferase, synthesizes UMP from uracil; involved in the pyrimidine salvage pathway
YHL015W 8.05
RPS20
Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; has similarity to E. coli S10 and rat S20 ribosomal proteins
YLR432W 8.05
IMD3
Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
YKL219W 8.01
COS9
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YGR050C 8.00 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL075W 7.95
GCR1
Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p
YOR028C 7.76
CIN5
Basic leucine zipper transcriptional factor of the yAP-1 family that mediates pleiotropic drug resistance and salt tolerance; localizes constitutively to the nucleus
YBR106W 7.60
PHO88
Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations
YOR047C 7.45
STD1
Protein involved in control of glucose-regulated gene expression; interacts with protein kinase Snf1p, glucose sensors Snf3p and Rgt2p, and TATA-binding protein Spt15p; acts as a regulator of the transcription factor Rgt1p
YGR241C 7.44
YAP1802
Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1801p, member of the AP180 protein family
YDL075W 7.41
RPL31A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Bp and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p
YKL009W 7.27
MRT4
Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus
YDR044W 7.26
HEM13
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YIL069C 7.13
RPS24B
Protein component of the small (40S) ribosomal subunit; identical to Rps24Ap and has similarity to rat S24 ribosomal protein
YGR123C 7.11
PPT1
Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth; computational analyses suggest roles in phosphate metabolism and rRNA processing
YNL065W 7.11
AQR1
Plasma membrane multidrug transporter of the major facilitator superfamily, confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids
YKR092C 7.01
SRP40
Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YNL111C 6.99
CYB5
Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
YGR251W 6.99 Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YLR110C 6.98
CCW12
Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor
YJL216C 6.92 Protein of unknown function, similar to alpha-D-glucosidases; transcriptionally activated by both Pdr8p and Yrm1p, along with transporters and other genes involved in the pleiotropic drug resistance (PDR) phenomenon
YGL157W 6.89 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YJL107C 6.85 Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
YGR140W 6.85
CBF2
Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo
YGR139W 6.81 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL034C 6.77 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL014W 6.72 Putative protein of unknown function
YGR017W 6.71 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
YPR157W 6.61 Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YHR216W 6.57
IMD2
Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation
YGR124W 6.52
ASN2
Asparagine synthetase, isozyme of Asn1p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway
YER028C 6.52
MIG3
Probable transcriptional repressor involved in response to toxic agents such as hydroxyurea that inhibit ribonucleotide reductase; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes
YNR013C 6.51
PHO91
Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YGL039W 6.49 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YMR123W 6.25
PKR1
V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); overproduction confers resistance to Pichia farinosa killer toxin
YOR312C 6.10
RPL20B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Ap and has similarity to rat L18a ribosomal protein
YAL003W 6.08
EFB1
Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site
YGL253W 6.05
HXK2
Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene
YPR043W 5.99
RPL43A
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Bp and has similarity to rat L37a ribosomal protein; null mutation confers a dominant lethal phenotype
YDR133C 5.92 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YLR413W 5.73 Putative protein of unknown function; YLR413W is not an essential gene
YPL198W 5.69
RPL7B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Ap and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)
YDR278C 5.64 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER049W 5.63
TPA1
Protein of unknown function; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; has a role in translation termination efficiency, mRNA poly(A) tail length and mRNA stability
YKR099W 5.62
BAS1
Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes
YFL022C 5.47
FRS2
Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
YOR050C 5.40 Hypothetical protein
YLR344W 5.33
RPL26A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Bp and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA
YGR051C 5.29 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene
YJR105W 5.10
ADO1
Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
YKL063C 5.10 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
YDR041W 5.08
RSM10
Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
YBL092W 5.08
RPL32
Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing
YML026C 5.06
RPS18B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Ap and has similarity to E. coli S13 and rat S18 ribosomal proteins
YPR163C 5.05
TIF3
Translation initiation factor eIF-4B, has RNA annealing activity; contains an RNA recognition motif and binds to single-stranded RNA
YDL048C 5.04
STP4
Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p
YDL241W 5.02 Putative protein of unknown function; YDL241W is not an essential gene
YGR287C 5.00 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; has similarity to alpha-D-glucosidase (maltase); authentic, non-tagged protein detected in purified mitochondria in high-throughput studies
YIL118W 4.93
RHO3
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YMR217W 4.84
GUA1
GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation
YGR034W 4.73
RPL26B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Ap and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA
YBR238C 4.71 Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span
YHR010W 4.70
RPL27A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Bp and has similarity to rat L27 ribosomal protein
YDL023C 4.65 Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
YKR026C 4.62
GCN3
Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression
YJL106W 4.56
IME2
Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p
YML075C 4.53
HMG1
One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae
YOR356W 4.51 Mitochondrial protein with similarity to flavoprotein-type oxidoreductases; found in a large supramolecular complex with other mitochondrial dehydrogenases
YPR010C 4.51
RPA135
RNA polymerase I subunit A135
YML052W 4.51
SUR7
Putative integral membrane protein; component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
YML077W 4.50
BET5
Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi
YLR285W 4.48
NNT1
Putative nicotinamide N-methyltransferase, has a role in rDNA silencing and in lifespan determination
YIL009W 4.41
FAA3
Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YGL035C 4.34
MIG1
Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase
YGL040C 4.33
HEM2
Delta-aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen, the second step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus
YNR001W-A 4.31 Dubious open reading frame unlikely to encode a functional protein; identified by homology
YDR381W 4.31
YRA1
Nuclear protein that binds to RNA and to Mex67p, required for export of poly(A)+ mRNA from the nucleus; member of the REF (RNA and export factor binding proteins) family; another family member, Yra2p, can substitute for Yra1p function
YDR047W 4.29
HEM12
Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; activity inhibited by Cu2+, Zn2+, Fe2+, Fe3+ and sulfhydryl-specific reagents
YDR040C 4.24
ENA1
P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance
YGR085C 4.23
RPL11B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11
YKL154W 4.19
SRP102
Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors Srp101p to the ER membrane
YDR071C 4.18
PAA1
Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication
YPL263C 4.18
KEL3
Cytoplasmic protein of unknown function
YKL180W 4.13
RPL17A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Bp and has similarity to E. coli L22 and rat L17 ribosomal proteins; copurifies with the Dam1 complex (aka DASH complex)
YHR046C 4.13
INM1
Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate
YFL015W-A 4.13 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR095C 4.07 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL158C 3.96
CIS3
Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
YDL022W 3.95
GPD1
NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p
YFL015C 3.91 Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
YER055C 3.89
HIS1
ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
YGL201C 3.89
MCM6
Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YMR015C 3.89
ERG5
C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
YDL055C 3.83
PSA1
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YEL027W 3.82
CUP5
Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis
YLR262C 3.77
YPT6
GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
YOR030W 3.77
DFG16
Probable multiple transmembrane protein, involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; required for accumulation of processed Rim101p
YIL169C 3.75 Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene
YLR167W 3.72
RPS31
Fusion protein that is cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B
YLR249W 3.65
YEF3
Translational elongation factor 3, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex; contains two ABC cassettes; binds and hydrolyses ATP
YCR006C 3.64 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR037W 3.64
KRS1
Lysyl-tRNA synthetase; also identified as a negative regulator of general control of amino acid biosynthesis
YER137C 3.64 Putative protein of unknown function
YIL009C-A 3.59
EST3
Component of the telomerase holoenzyme, involved in telomere replication
YLR420W 3.59
URA4
Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
YGR106C 3.59
VOA1
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane
YKL080W 3.58
VMA5
Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
YNL096C 3.58
RPS7B
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Ap; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
YOL130W 3.57
ALR1
Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions
YOL101C 3.54
IZH4
Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism
YLR328W 3.54
NMA1
Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways
YMR246W 3.52
FAA4
Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipids
YGL009C 3.52
LEU1
Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway
YDL022C-A 3.50 Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene DIA3; identified by fungal homology and RT-PCR
YDR094W 3.49 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
YOL015W 3.41
IRC10
Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci
YKL218C 3.39
SRY1
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YOR004W 3.38
UTP23
Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function
YDL111C 3.37
RRP42
Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex with Rrp4p, Rrp41p, Rrp43p and Dis3p
YHR031C 3.35
RRM3
DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p
YER183C 3.33
FAU1
5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis
YBR137W 3.32 Protein of unknown function; localized to the cytoplasm; binds to Replication Protein A (RPA); YBR137W is not an essential gene
YGL078C 3.32
DBP3
Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis
YDR170C 3.30
SEC7
Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
YBL077W 3.26 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C
YLL024C 3.25
SSA2
ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall
YKL065C 3.24
YET1
Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
YGL031C 3.24
RPL24A
Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YER048C 3.23
CAJ1
Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly
YER048W-A 3.20
ISD11
Protein required for mitochondrial iron-sulfur cluster biosynthesis
YIR012W 3.19
SQT1
Essential protein involved in a late step of 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay
YNR054C 3.19
ESF2
Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
YMR038C 3.18
CCS1
Copper chaperone for superoxide dismutase Sod1p, involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation
YPL267W 3.18
ACM1
Cell cycle regulated protein of unknown function; associated with Cdh1p and may supress the APC/C[Cdh1]-mediated proteolysis of mitotic cyclins
YIL039W 3.17
TED1
Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YHR021C 3.17
RPS27B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Ap and has similarity to rat S27 ribosomal protein
YMR012W 3.17
CLU1
eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant
YDR447C 3.16
RPS17B
Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Ap and has similarity to rat S17 ribosomal protein
YGR107W 3.16 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOL124C 3.14
TRM11
Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
YEL029C 3.10
BUD16
Putative pyridoxal kinase, key enzyme in vitamin B6 metabolism; involved in maintaining levels of pyridoxal 5'-phosphate, the active form of vitamin B6; required for genome integrity; homolog of E. coli PdxK; involved in bud-site selection
YKL120W 3.03
OAC1
Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, and thiosulfate; member of the mitochondrial carrier family
YEL020C-B 3.03 Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene YEL020W-A; identified by fungal homology and RT-PCR
YPL183C 3.03
RTT10
Cytoplasmic protein with a role in regulation of Ty1 transposition
YAR008W 3.02
SEN34
Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
YLR300W 3.01
EXG1
Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes
YGL202W 2.91
ARO8
Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis
YPL231W 2.90
FAS2
Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains beta-ketoacyl reductase and beta-ketoacyl synthase activities; phosphorylated
YER107W-A 2.87 Dubious open reading frame unlikely to encode a protein, partially overlaps verified ORF GLE2/YER107C
YGR189C 2.86
CRH1
Putative chitin transglycosidase, cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; localizes to sites of polarized growth; expression is induced under cell wall stress conditions
YDR144C 2.86
MKC7
GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p
YGL030W 2.84
RPL30
Protein component of the large (60S) ribosomal subunit, has similarity to rat L30 ribosomal protein; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript
YPR051W 2.83
MAK3
Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus
YJL115W 2.79
ASF1
Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition
YMR037C 2.78
MSN2
Transcriptional activator related to Msn4p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression
YBR009C 2.77
HHF1
One of two identical histone H4 proteins (see also HHF2); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
YJL179W 2.75
PFD1
Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin
YIL148W 2.73
RPL40A
Fusion protein, identical to Rpl40Bp, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes
YOL022C 2.72
TSR4
Cytoplasmic protein of unknown function; essential gene in S288C, and non-essential with reduced growth rate in CEN.PK2; Null mutant accumulates 20S pre-rRNA
YER107C 2.68
GLE2
Component of the nuclear pore complex required for polyadenylated RNA export but not for protein import, homologous to S. pombe Rae1p
YNL110C 2.67
NOP15
Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm

Network of associatons between targets according to the STRING database.

First level regulatory network of RGT1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
24.8 74.5 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
6.4 25.6 GO:1900436 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
5.2 36.3 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
3.9 19.5 GO:0006177 GMP biosynthetic process(GO:0006177)
3.1 12.4 GO:0000296 spermine transport(GO:0000296)
2.7 29.2 GO:0015758 glucose transport(GO:0015758)
2.7 8.0 GO:0072361 regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361) regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072363)
2.5 7.4 GO:0070637 nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637)
2.3 9.3 GO:0071482 cellular response to radiation(GO:0071478) cellular response to light stimulus(GO:0071482)
2.3 15.9 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
2.3 15.9 GO:0046501 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
2.2 6.5 GO:0006529 asparagine biosynthetic process(GO:0006529)
2.0 8.1 GO:0043097 pyrimidine ribonucleotide salvage(GO:0010138) pyrimidine nucleotide salvage(GO:0032262) pyrimidine nucleoside salvage(GO:0043097) UMP salvage(GO:0044206)
1.8 5.5 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
1.8 7.1 GO:0098609 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
1.7 5.1 GO:1904667 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
1.6 7.9 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
1.6 6.3 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
1.6 1.6 GO:0061422 positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH(GO:0061422)
1.4 15.4 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
1.4 11.0 GO:0006814 sodium ion transport(GO:0006814)
1.3 2.7 GO:2000197 regulation of mRNA export from nucleus(GO:0010793) regulation of nucleobase-containing compound transport(GO:0032239) regulation of RNA export from nucleus(GO:0046831) regulation of ribonucleoprotein complex localization(GO:2000197)
1.3 3.8 GO:0019673 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
1.2 3.6 GO:0015693 magnesium ion transport(GO:0015693)
1.2 4.7 GO:0090338 regulation of formin-nucleated actin cable assembly(GO:0090337) positive regulation of formin-nucleated actin cable assembly(GO:0090338)
1.2 12.8 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
1.1 5.7 GO:0034032 coenzyme A metabolic process(GO:0015936) nucleoside bisphosphate metabolic process(GO:0033865) ribonucleoside bisphosphate metabolic process(GO:0033875) purine nucleoside bisphosphate metabolic process(GO:0034032)
1.1 9.2 GO:0000376 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
1.1 6.7 GO:0032973 amino acid export(GO:0032973)
1.1 4.4 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
1.1 7.5 GO:0043457 regulation of cellular respiration(GO:0043457)
1.0 3.0 GO:0008272 sulfate transport(GO:0008272)
1.0 3.0 GO:1901351 regulation of phosphatidylglycerol biosynthetic process(GO:1901351) negative regulation of phosphatidylglycerol biosynthetic process(GO:1901352)
1.0 2.9 GO:0006571 tyrosine biosynthetic process(GO:0006571) L-phenylalanine biosynthetic process(GO:0009094) erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process(GO:1902223)
1.0 8.6 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
1.0 15.2 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.9 2.8 GO:0048024 regulation of RNA splicing(GO:0043484) regulation of mRNA splicing, via spliceosome(GO:0048024)
0.9 0.9 GO:0045338 terpenoid metabolic process(GO:0006721) terpenoid biosynthetic process(GO:0016114) farnesyl diphosphate biosynthetic process(GO:0045337) farnesyl diphosphate metabolic process(GO:0045338)
0.9 131.6 GO:0002181 cytoplasmic translation(GO:0002181)
0.9 19.9 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.9 12.5 GO:0006415 translational termination(GO:0006415)
0.9 2.7 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
0.9 2.6 GO:0043171 peptide catabolic process(GO:0043171)
0.9 7.7 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.9 2.6 GO:0000092 mitotic anaphase B(GO:0000092) plasmid partitioning(GO:0030541)
0.8 1.6 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.8 0.8 GO:0033239 negative regulation of cellular amine metabolic process(GO:0033239)
0.8 3.1 GO:0015680 intracellular copper ion transport(GO:0015680)
0.8 2.3 GO:0006407 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
0.8 3.0 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.7 6.6 GO:0051231 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231)
0.7 9.4 GO:0006037 cell wall chitin metabolic process(GO:0006037)
0.7 2.1 GO:0010942 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.7 4.1 GO:0042538 hyperosmotic salinity response(GO:0042538)
0.7 0.7 GO:0046037 GMP metabolic process(GO:0046037)
0.7 3.4 GO:1901985 positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.7 2.0 GO:0010922 positive regulation of phosphatase activity(GO:0010922)
0.7 3.4 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.7 2.7 GO:0031032 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin structure organization(GO:0031032) actomyosin contractile ring organization(GO:0044837)
0.7 3.3 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.6 1.8 GO:0071545 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
0.6 1.8 GO:1901072 aminoglycan catabolic process(GO:0006026) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.6 5.3 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.6 2.4 GO:0015780 nucleotide-sugar transport(GO:0015780)
0.6 1.8 GO:0031384 regulation of initiation of mating projection growth(GO:0031384)
0.6 12.9 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.6 3.5 GO:0006116 NADH oxidation(GO:0006116)
0.6 2.3 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.6 2.9 GO:0070814 hydrogen sulfide metabolic process(GO:0070813) hydrogen sulfide biosynthetic process(GO:0070814)
0.6 2.3 GO:0030497 fatty acid elongation(GO:0030497)
0.6 12.8 GO:0006334 nucleosome assembly(GO:0006334)
0.6 2.3 GO:0009090 homoserine biosynthetic process(GO:0009090)
0.6 3.9 GO:0034063 stress granule assembly(GO:0034063)
0.6 1.1 GO:0031111 negative regulation of microtubule depolymerization(GO:0007026) negative regulation of microtubule polymerization or depolymerization(GO:0031111) regulation of microtubule depolymerization(GO:0031114)
0.6 3.9 GO:0009098 leucine biosynthetic process(GO:0009098)
0.6 0.6 GO:0046898 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
0.5 1.6 GO:0044209 AMP salvage(GO:0044209)
0.5 1.1 GO:0070475 rRNA base methylation(GO:0070475)
0.5 1.6 GO:0000433 negative regulation of transcription from RNA polymerase II promoter by glucose(GO:0000433) negative regulation of transcription by glucose(GO:0045014)
0.5 10.2 GO:0006614 cotranslational protein targeting to membrane(GO:0006613) SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.5 11.7 GO:0002098 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.5 0.5 GO:0031555 transcriptional attenuation(GO:0031555) transcription antitermination(GO:0031564)
0.5 5.3 GO:0006547 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.5 1.6 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.5 2.5 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.5 2.0 GO:0010674 negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010674)
0.5 1.9 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
0.5 8.7 GO:0042797 tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.5 15.9 GO:0016126 steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126)
0.5 4.8 GO:0051320 mitotic S phase(GO:0000084) S phase(GO:0051320)
0.4 12.9 GO:0045454 cell redox homeostasis(GO:0045454)
0.4 3.8 GO:0006882 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.4 8.8 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.4 1.7 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
0.4 5.7 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.4 1.6 GO:0015867 ATP transport(GO:0015867)
0.4 8.1 GO:0007004 RNA-dependent DNA biosynthetic process(GO:0006278) telomere maintenance via telomerase(GO:0007004) telomere maintenance via telomere lengthening(GO:0010833)
0.4 1.6 GO:0008614 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.4 1.2 GO:0052646 phosphatidylserine metabolic process(GO:0006658) alditol phosphate metabolic process(GO:0052646)
0.4 2.3 GO:0046184 pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823) aldehyde biosynthetic process(GO:0046184)
0.4 5.6 GO:0071051 polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.4 3.7 GO:0006057 cell wall mannoprotein biosynthetic process(GO:0000032) mannoprotein metabolic process(GO:0006056) mannoprotein biosynthetic process(GO:0006057) cell wall glycoprotein biosynthetic process(GO:0031506)
0.4 1.1 GO:0044819 mitotic G1 DNA damage checkpoint(GO:0031571) mitotic G1/S transition checkpoint(GO:0044819)
0.4 1.4 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.4 5.4 GO:0030488 tRNA methylation(GO:0030488)
0.4 3.6 GO:0015988 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.4 4.6 GO:0006446 regulation of translational initiation(GO:0006446)
0.4 1.1 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.3 1.0 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.3 0.3 GO:0009135 purine nucleoside diphosphate metabolic process(GO:0009135) purine ribonucleoside diphosphate metabolic process(GO:0009179) ribonucleoside diphosphate metabolic process(GO:0009185) ADP metabolic process(GO:0046031)
0.3 1.0 GO:0000087 mitotic M phase(GO:0000087) M phase(GO:0000279)
0.3 1.0 GO:0046473 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.3 0.7 GO:0019348 polyprenol metabolic process(GO:0016093) polyprenol biosynthetic process(GO:0016094) dolichol metabolic process(GO:0019348) dolichol biosynthetic process(GO:0019408)
0.3 3.6 GO:0009435 NAD biosynthetic process(GO:0009435)
0.3 6.7 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) maturation of LSU-rRNA(GO:0000470)
0.3 0.9 GO:0048313 Golgi inheritance(GO:0048313)
0.3 2.5 GO:0090522 vesicle tethering involved in exocytosis(GO:0090522)
0.3 2.2 GO:0006797 polyphosphate metabolic process(GO:0006797)
0.3 1.5 GO:0030042 actin filament depolymerization(GO:0030042)
0.3 3.0 GO:0006730 one-carbon metabolic process(GO:0006730)
0.3 19.5 GO:0016311 dephosphorylation(GO:0016311)
0.3 0.9 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.3 3.2 GO:0006611 protein export from nucleus(GO:0006611)
0.3 4.3 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.3 0.6 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.3 2.8 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396) pteridine-containing compound biosynthetic process(GO:0042559)
0.3 1.1 GO:0034503 protein localization to nucleolar rDNA repeats(GO:0034503)
0.3 1.6 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.3 2.7 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity(GO:0051090)
0.3 1.3 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.3 3.7 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.3 5.7 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.3 2.0 GO:0006817 phosphate ion transport(GO:0006817)
0.3 5.5 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.2 2.0 GO:0006901 vesicle coating(GO:0006901)
0.2 6.8 GO:0040020 regulation of meiotic nuclear division(GO:0040020) regulation of meiotic cell cycle(GO:0051445)
0.2 1.7 GO:0046513 ceramide metabolic process(GO:0006672) ceramide biosynthetic process(GO:0046513)
0.2 2.2 GO:0030011 maintenance of cell polarity(GO:0030011)
0.2 3.1 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.2 1.9 GO:0009303 rRNA transcription(GO:0009303)
0.2 1.2 GO:0009757 cellular glucose homeostasis(GO:0001678) carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255) carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.2 0.9 GO:0007535 donor selection(GO:0007535)
0.2 0.9 GO:0015883 FAD transport(GO:0015883)
0.2 0.9 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.2 0.7 GO:0048279 vesicle fusion with endoplasmic reticulum(GO:0048279)
0.2 1.3 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.2 1.1 GO:0006541 glutamine metabolic process(GO:0006541)
0.2 5.4 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.2 1.9 GO:0055070 cellular copper ion homeostasis(GO:0006878) copper ion homeostasis(GO:0055070)
0.2 0.6 GO:0043489 RNA stabilization(GO:0043489) mRNA stabilization(GO:0048255)
0.2 0.8 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.2 0.2 GO:0006531 aspartate metabolic process(GO:0006531)
0.2 19.8 GO:0006364 rRNA processing(GO:0006364)
0.2 1.0 GO:0046219 tryptophan biosynthetic process(GO:0000162) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
0.2 0.8 GO:0009073 aromatic amino acid family biosynthetic process(GO:0009073) chorismate biosynthetic process(GO:0009423) chorismate metabolic process(GO:0046417)
0.2 0.8 GO:0043471 regulation of carbohydrate catabolic process(GO:0043470) regulation of cellular carbohydrate catabolic process(GO:0043471)
0.2 5.9 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.2 0.6 GO:0046677 response to antibiotic(GO:0046677)
0.2 0.2 GO:1900544 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.2 0.9 GO:0006734 NADH metabolic process(GO:0006734)
0.2 12.3 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.2 1.6 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.2 0.9 GO:0006356 regulation of transcription from RNA polymerase I promoter(GO:0006356)
0.2 1.0 GO:0035376 sterol import(GO:0035376)
0.2 0.8 GO:0015793 glycerol transport(GO:0015793)
0.2 3.7 GO:0006414 translational elongation(GO:0006414)
0.2 5.3 GO:0008033 tRNA processing(GO:0008033)
0.2 0.3 GO:0015868 purine nucleotide transport(GO:0015865) purine ribonucleotide transport(GO:0015868)
0.2 0.2 GO:0032447 protein urmylation(GO:0032447)
0.2 2.1 GO:0006379 mRNA cleavage(GO:0006379)
0.2 0.3 GO:0030847 termination of RNA polymerase II transcription, exosome-dependent(GO:0030847)
0.2 2.8 GO:0022406 membrane docking(GO:0022406)
0.2 0.6 GO:0009164 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.2 0.6 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.2 0.6 GO:0034501 protein localization to kinetochore(GO:0034501)
0.2 0.3 GO:0034729 histone H3-K79 methylation(GO:0034729)
0.2 0.8 GO:0000707 meiotic DNA recombinase assembly(GO:0000707) DNA recombinase assembly(GO:0000730)
0.1 2.1 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 1.6 GO:0000742 karyogamy involved in conjugation with cellular fusion(GO:0000742)
0.1 1.9 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.1 0.5 GO:0051126 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) negative regulation of actin nucleation(GO:0051126)
0.1 0.4 GO:0015886 heme transport(GO:0015886)
0.1 0.1 GO:0007030 Golgi organization(GO:0007030)
0.1 0.9 GO:0007009 plasma membrane organization(GO:0007009)
0.1 0.4 GO:0006657 CDP-choline pathway(GO:0006657)
0.1 0.9 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889) regulation of vacuole organization(GO:0044088)
0.1 2.5 GO:0006413 translational initiation(GO:0006413)
0.1 0.9 GO:0007035 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.1 0.2 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.1 0.8 GO:0016125 steroid metabolic process(GO:0008202) sterol metabolic process(GO:0016125)
0.1 2.6 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.1 0.4 GO:0051865 protein autoubiquitination(GO:0051865)
0.1 0.9 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 1.9 GO:0043248 proteasome assembly(GO:0043248)
0.1 0.8 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.1 0.2 GO:0070827 chromatin maintenance(GO:0070827)
0.1 0.4 GO:0006972 hyperosmotic response(GO:0006972)
0.1 3.2 GO:0032259 methylation(GO:0032259)
0.1 1.1 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.1 0.5 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.1 0.2 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.1 1.1 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.1 0.1 GO:0032006 regulation of TOR signaling(GO:0032006)
0.1 1.3 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.1 0.7 GO:0033673 negative regulation of protein kinase activity(GO:0006469) negative regulation of kinase activity(GO:0033673)
0.1 1.1 GO:0046785 microtubule nucleation(GO:0007020) microtubule polymerization(GO:0046785)
0.1 0.7 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.1 0.2 GO:0019359 nicotinamide nucleotide biosynthetic process(GO:0019359)
0.1 0.2 GO:0072417 cellular response to biotic stimulus(GO:0071216) response to cell cycle checkpoint signaling(GO:0072396) response to mitotic cell cycle checkpoint signaling(GO:0072414) response to spindle checkpoint signaling(GO:0072417) response to mitotic spindle checkpoint signaling(GO:0072476) response to mitotic cell cycle spindle assembly checkpoint signaling(GO:0072479) response to spindle assembly checkpoint signaling(GO:0072485) negative regulation of protein import into nucleus during spindle assembly checkpoint(GO:1901925)
0.1 0.4 GO:0042991 transcription factor import into nucleus(GO:0042991)
0.0 0.4 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.0 0.2 GO:0051028 mRNA transport(GO:0051028)
0.0 0.1 GO:0008299 isoprenoid metabolic process(GO:0006720) isoprenoid biosynthetic process(GO:0008299)
0.0 0.1 GO:0045833 negative regulation of lipid metabolic process(GO:0045833)
0.0 0.3 GO:0046854 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.4 GO:0030473 establishment of localization by movement along microtubule(GO:0010970) nuclear migration along microtubule(GO:0030473) organelle transport along microtubule(GO:0072384)
0.0 0.3 GO:0019856 pyrimidine nucleobase biosynthetic process(GO:0019856)
0.0 3.2 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.4 GO:0006273 lagging strand elongation(GO:0006273)
0.0 0.3 GO:0007120 axial cellular bud site selection(GO:0007120)
0.0 0.1 GO:0009415 response to water(GO:0009415) cellular response to water stimulus(GO:0071462)
0.0 0.1 GO:0010978 gene silencing involved in chronological cell aging(GO:0010978) gene silencing by RNA(GO:0031047)
0.0 0.1 GO:0019401 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.0 0.3 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.0 1.6 GO:0051169 nucleocytoplasmic transport(GO:0006913) nuclear transport(GO:0051169)
0.0 0.3 GO:0090529 barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529)
0.0 0.1 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.0 0.6 GO:0046467 membrane lipid biosynthetic process(GO:0046467)
0.0 0.1 GO:0007323 peptide pheromone maturation(GO:0007323)
0.0 0.0 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.0 0.2 GO:0006526 arginine biosynthetic process(GO:0006526)
0.0 0.2 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.2 GO:0044774 mitotic DNA integrity checkpoint(GO:0044774)
0.0 0.1 GO:0015939 pantothenate metabolic process(GO:0015939) pantothenate biosynthetic process(GO:0015940)
0.0 0.0 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.0 0.0 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.0 0.1 GO:0000077 DNA damage checkpoint(GO:0000077)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
12.0 36.0 GO:0032299 ribonuclease H2 complex(GO:0032299)
1.9 9.3 GO:0000408 EKC/KEOPS complex(GO:0000408)
1.7 6.9 GO:0031518 CBF3 complex(GO:0031518)
1.5 7.7 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
1.5 4.5 GO:0031417 NatC complex(GO:0031417)
1.5 4.4 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
1.2 1.2 GO:0000133 polarisome(GO:0000133)
1.1 13.8 GO:0030688 preribosome, small subunit precursor(GO:0030688)
1.1 94.2 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
1.1 4.3 GO:0030287 cell wall-bounded periplasmic space(GO:0030287)
1.1 5.3 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
1.0 2.9 GO:0031415 NatA complex(GO:0031415)
1.0 2.9 GO:0000131 incipient cellular bud site(GO:0000131)
0.9 54.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.9 4.4 GO:0005641 nuclear envelope lumen(GO:0005641)
0.9 2.6 GO:0070545 PeBoW complex(GO:0070545)
0.8 31.3 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.8 4.7 GO:0000136 alpha-1,6-mannosyltransferase complex(GO:0000136)
0.8 9.3 GO:0000788 nuclear nucleosome(GO:0000788)
0.8 4.6 GO:0042555 MCM complex(GO:0042555)
0.8 3.8 GO:0034044 exomer complex(GO:0034044)
0.8 3.0 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.7 12.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.7 2.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.6 4.4 GO:0033180 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.6 4.4 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.6 4.3 GO:0000346 transcription export complex(GO:0000346)
0.6 4.8 GO:0030126 COPI vesicle coat(GO:0030126)
0.6 8.4 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.6 2.4 GO:0070860 RNA polymerase I core factor complex(GO:0070860)
0.6 6.4 GO:0030867 rough endoplasmic reticulum(GO:0005791) rough endoplasmic reticulum membrane(GO:0030867)
0.6 2.9 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.6 4.5 GO:0030008 TRAPP complex(GO:0030008)
0.6 1.1 GO:0030428 cell septum(GO:0030428)
0.5 1.6 GO:0000814 ESCRT II complex(GO:0000814)
0.5 1.6 GO:0034457 Mpp10 complex(GO:0034457)
0.5 10.1 GO:0030118 clathrin coat(GO:0030118)
0.5 5.3 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.5 4.2 GO:0031933 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.5 3.1 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.5 1.6 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.5 3.6 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.5 1.5 GO:0070985 TFIIK complex(GO:0070985)
0.5 1.5 GO:0071561 nucleus-vacuole junction(GO:0071561)
0.5 2.7 GO:0016272 prefoldin complex(GO:0016272)
0.5 1.4 GO:0005823 central plaque of spindle pole body(GO:0005823)
0.4 6.1 GO:0022626 cytosolic ribosome(GO:0022626)
0.4 0.9 GO:0000786 nucleosome(GO:0000786)
0.4 2.6 GO:0005871 kinesin complex(GO:0005871)
0.4 5.4 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.4 5.7 GO:0034399 nuclear periphery(GO:0034399)
0.4 2.4 GO:0032126 eisosome(GO:0032126)
0.4 3.6 GO:0000144 cellular bud neck septin ring(GO:0000144)
0.4 1.2 GO:0005825 half bridge of spindle pole body(GO:0005825)
0.4 1.6 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.4 1.1 GO:0035649 Nrd1 complex(GO:0035649)
0.3 1.0 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.3 0.7 GO:0000178 nuclear exosome (RNase complex)(GO:0000176) exosome (RNase complex)(GO:0000178)
0.3 17.8 GO:0030684 preribosome(GO:0030684)
0.3 11.9 GO:0005811 lipid particle(GO:0005811)
0.3 0.9 GO:0046930 pore complex(GO:0046930)
0.3 2.5 GO:0000145 exocyst(GO:0000145)
0.3 3.1 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.3 1.1 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.3 1.3 GO:0034518 RNA cap binding complex(GO:0034518)
0.3 1.8 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.3 44.8 GO:0005933 cellular bud(GO:0005933)
0.3 1.8 GO:0051233 spindle midzone(GO:0051233)
0.2 1.9 GO:0017119 Golgi transport complex(GO:0017119)
0.2 1.4 GO:0000782 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.2 0.9 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.2 1.5 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.2 0.4 GO:0000137 Golgi cis cisterna(GO:0000137)
0.2 1.6 GO:0005688 U6 snRNP(GO:0005688)
0.2 0.6 GO:0005662 DNA replication factor A complex(GO:0005662)
0.2 0.6 GO:0030896 checkpoint clamp complex(GO:0030896)
0.2 0.2 GO:0034099 luminal surveillance complex(GO:0034099)
0.2 1.3 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.2 0.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.2 6.6 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.2 1.0 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.2 2.7 GO:0005798 Golgi-associated vesicle(GO:0005798)
0.2 0.5 GO:0030874 nucleolar chromatin(GO:0030874)
0.2 5.9 GO:0030133 transport vesicle(GO:0030133)
0.2 0.5 GO:0000417 HIR complex(GO:0000417)
0.2 0.9 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.2 2.9 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.1 0.6 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.1 0.7 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 0.4 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1 0.5 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1 13.0 GO:0005730 nucleolus(GO:0005730)
0.1 0.3 GO:0031414 N-terminal protein acetyltransferase complex(GO:0031414)
0.1 0.2 GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.1 1.3 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 2.9 GO:0005844 polysome(GO:0005844)
0.1 3.8 GO:0015935 small ribosomal subunit(GO:0015935)
0.1 0.4 GO:0000811 GINS complex(GO:0000811)
0.1 1.3 GO:0031201 SNARE complex(GO:0031201)
0.1 31.0 GO:0005886 plasma membrane(GO:0005886)
0.1 5.4 GO:0000139 Golgi membrane(GO:0000139)
0.1 0.2 GO:0000792 heterochromatin(GO:0000792)
0.1 1.1 GO:0046695 SLIK (SAGA-like) complex(GO:0046695)
0.1 3.0 GO:0044445 cytosolic part(GO:0044445)
0.1 7.1 GO:0005635 nuclear envelope(GO:0005635)
0.1 1.4 GO:0016586 RSC complex(GO:0016586)
0.1 0.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 0.2 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
0.1 0.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 0.4 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.1 0.4 GO:0072686 mitotic spindle(GO:0072686)
0.1 0.6 GO:0000243 commitment complex(GO:0000243)
0.1 0.4 GO:0070772 PAS complex(GO:0070772)
0.1 9.0 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.1 0.8 GO:0000502 proteasome complex(GO:0000502)
0.0 0.4 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 0.2 GO:0098827 cortical endoplasmic reticulum(GO:0032541) endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0 0.2 GO:0034448 EGO complex(GO:0034448)
0.0 0.1 GO:0097255 R2TP complex(GO:0097255)
0.0 0.1 GO:0016587 Isw1 complex(GO:0016587)
0.0 0.2 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.1 GO:0070823 HDA1 complex(GO:0070823)
0.0 0.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.2 GO:0000974 Prp19 complex(GO:0000974)
0.0 0.1 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.3 GO:0036452 ESCRT complex(GO:0036452)
0.0 0.4 GO:0071010 U2-type prespliceosome(GO:0071004) prespliceosome(GO:0071010)
0.0 1.7 GO:0005840 ribosome(GO:0005840)
0.0 0.2 GO:0034708 methyltransferase complex(GO:0034708)
0.0 0.9 GO:0015630 microtubule cytoskeleton(GO:0015630)
0.0 0.1 GO:0031391 Elg1 RFC-like complex(GO:0031391)
0.0 0.1 GO:0000798 nuclear cohesin complex(GO:0000798) cohesin complex(GO:0008278)
0.0 0.1 GO:0005669 transcription factor TFIID complex(GO:0005669)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
11.3 45.2 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
10.1 60.5 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
9.2 36.8 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
4.9 14.6 GO:0003938 IMP dehydrogenase activity(GO:0003938)
3.1 12.4 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
2.2 8.9 GO:0016417 S-acyltransferase activity(GO:0016417)
2.0 8.0 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
2.0 7.9 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
1.9 9.7 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
1.9 5.6 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
1.8 5.5 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
1.8 7.3 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
1.8 17.9 GO:0015578 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
1.8 10.7 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
1.7 25.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.7 5.1 GO:0033592 RNA strand annealing activity(GO:0033592) annealing activity(GO:0097617)
1.5 9.2 GO:0003993 acid phosphatase activity(GO:0003993)
1.4 14.3 GO:0005216 ion channel activity(GO:0005216)
1.4 4.1 GO:0070568 guanylyltransferase activity(GO:0070568)
1.3 3.9 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
1.3 5.1 GO:0019206 nucleoside kinase activity(GO:0019206)
1.2 3.6 GO:0016882 cyclo-ligase activity(GO:0016882)
1.2 3.6 GO:0015248 sterol transporter activity(GO:0015248)
1.2 2.3 GO:0032451 demethylase activity(GO:0032451)
1.1 6.9 GO:0019237 centromeric DNA binding(GO:0019237)
1.1 13.2 GO:0005516 calmodulin binding(GO:0005516)
1.0 3.1 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
1.0 3.0 GO:0015116 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
1.0 4.9 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
1.0 3.9 GO:0009378 four-way junction helicase activity(GO:0009378)
0.9 16.7 GO:0019843 rRNA binding(GO:0019843)
0.9 9.3 GO:0031490 chromatin DNA binding(GO:0031490)
0.9 8.2 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.9 3.4 GO:0016841 ammonia-lyase activity(GO:0016841)
0.9 7.7 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.8 3.2 GO:0055106 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.8 3.1 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.8 2.3 GO:0008897 holo-[acyl-carrier-protein] synthase activity(GO:0008897)
0.8 3.0 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.8 3.0 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.7 19.8 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.7 3.7 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.7 11.7 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.7 148.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.7 8.3 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.7 2.1 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.7 2.0 GO:0051219 phosphoprotein binding(GO:0051219)
0.7 2.0 GO:0016504 peptidase activator activity(GO:0016504)
0.7 2.6 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.6 3.8 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.6 8.4 GO:0001054 RNA polymerase I activity(GO:0001054)
0.6 3.0 GO:0008525 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.6 6.0 GO:0030295 protein kinase activator activity(GO:0030295)
0.6 13.0 GO:0019901 protein kinase binding(GO:0019901)
0.6 4.5 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.6 1.7 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.6 16.1 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.5 2.1 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.5 5.3 GO:0001056 RNA polymerase III activity(GO:0001056)
0.5 4.7 GO:0000009 alpha-1,6-mannosyltransferase activity(GO:0000009)
0.5 2.1 GO:0008172 S-methyltransferase activity(GO:0008172)
0.5 2.6 GO:0017137 Rab GTPase binding(GO:0017137)
0.5 2.0 GO:0004338 glucan exo-1,3-beta-glucosidase activity(GO:0004338)
0.5 2.5 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.5 2.4 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.5 3.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.5 7.9 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.5 5.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.5 1.4 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.5 1.4 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.4 1.3 GO:0000339 RNA cap binding(GO:0000339)
0.4 6.2 GO:0070566 adenylyltransferase activity(GO:0070566)
0.4 1.3 GO:0015036 disulfide oxidoreductase activity(GO:0015036)
0.4 1.3 GO:0000146 microfilament motor activity(GO:0000146)
0.4 1.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.4 1.3 GO:0009922 fatty acid elongase activity(GO:0009922)
0.4 0.8 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.4 1.6 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.4 8.8 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.4 14.1 GO:0000287 magnesium ion binding(GO:0000287)
0.4 1.1 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.4 1.8 GO:0004707 MAP kinase activity(GO:0004707)
0.4 2.8 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.4 2.1 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.4 10.2 GO:0046982 protein heterodimerization activity(GO:0046982)
0.3 7.7 GO:0016835 carbon-oxygen lyase activity(GO:0016835)
0.3 1.0 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.3 1.9 GO:0030145 manganese ion binding(GO:0030145)
0.3 1.0 GO:0004100 chitin synthase activity(GO:0004100)
0.3 3.1 GO:0030276 clathrin binding(GO:0030276)
0.3 0.9 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.3 0.9 GO:0004000 adenosine deaminase activity(GO:0004000) tRNA-specific adenosine deaminase activity(GO:0008251)
0.3 3.7 GO:0070491 repressing transcription factor binding(GO:0070491)
0.3 4.2 GO:0001671 ATPase activator activity(GO:0001671)
0.3 5.0 GO:0042162 telomeric DNA binding(GO:0042162)
0.3 1.2 GO:0004771 sterol esterase activity(GO:0004771)
0.3 2.3 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.3 2.6 GO:0003727 single-stranded RNA binding(GO:0003727)
0.3 0.8 GO:0016670 protein disulfide isomerase activity(GO:0003756) oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) thiol oxidase activity(GO:0016972)
0.3 2.5 GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism(GO:0015662)
0.3 1.1 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.3 1.1 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.3 0.8 GO:0015188 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.2 2.0 GO:0003777 microtubule motor activity(GO:0003777)
0.2 1.2 GO:0004864 protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
0.2 6.4 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 4.3 GO:0051287 NAD binding(GO:0051287)
0.2 0.9 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.2 0.7 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.2 0.9 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.2 0.7 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.2 1.1 GO:0019211 phosphatase activator activity(GO:0019211)
0.2 2.0 GO:0019904 protein domain specific binding(GO:0019904)
0.2 4.9 GO:0008170 N-methyltransferase activity(GO:0008170)
0.2 1.3 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.2 1.3 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.2 0.6 GO:0072341 modified amino acid binding(GO:0072341)
0.2 1.0 GO:0019201 nucleotide kinase activity(GO:0019201)
0.2 1.9 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.2 1.5 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.2 0.8 GO:0004622 lysophospholipase activity(GO:0004622)
0.2 0.5 GO:0004312 fatty acid synthase activity(GO:0004312)
0.2 0.5 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.2 3.0 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.2 0.5 GO:0008252 nucleotidase activity(GO:0008252)
0.2 2.1 GO:0034061 DNA-directed DNA polymerase activity(GO:0003887) DNA polymerase activity(GO:0034061)
0.1 2.2 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.1 0.4 GO:0008242 omega peptidase activity(GO:0008242)
0.1 0.5 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.1 0.5 GO:0019238 cyclohydrolase activity(GO:0019238)
0.1 2.0 GO:0030515 snoRNA binding(GO:0030515)
0.1 1.3 GO:0051015 actin filament binding(GO:0051015)
0.1 0.9 GO:0016866 intramolecular transferase activity(GO:0016866)
0.1 1.2 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 3.1 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.1 1.5 GO:0015266 protein channel activity(GO:0015266)
0.1 2.5 GO:0005048 signal sequence binding(GO:0005048)
0.1 0.6 GO:0003774 motor activity(GO:0003774)
0.1 0.2 GO:0008443 phosphofructokinase activity(GO:0008443)
0.1 0.2 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 3.7 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds(GO:0016810)
0.1 3.5 GO:0043130 ubiquitin binding(GO:0043130)
0.1 0.7 GO:0015216 purine nucleotide transmembrane transporter activity(GO:0015216)
0.1 0.5 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.1 1.7 GO:0008017 microtubule binding(GO:0008017)
0.1 0.4 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.1 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.1 1.0 GO:0005199 structural constituent of cell wall(GO:0005199)
0.1 0.3 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 6.1 GO:0005543 phospholipid binding(GO:0005543)
0.1 0.2 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.1 2.8 GO:0008565 protein transporter activity(GO:0008565)
0.1 1.2 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.1 0.4 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.1 2.3 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 0.9 GO:0015238 drug transmembrane transporter activity(GO:0015238)
0.1 0.4 GO:0051183 vitamin transporter activity(GO:0051183)
0.1 0.2 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 0.2 GO:0042736 NAD+ kinase activity(GO:0003951) NADH kinase activity(GO:0042736)
0.1 1.1 GO:0031491 nucleosome binding(GO:0031491)
0.1 0.6 GO:0000049 tRNA binding(GO:0000049)
0.1 0.2 GO:0052744 phosphatidylinositol-3-phosphatase activity(GO:0004438) phosphatidylinositol monophosphate phosphatase activity(GO:0052744)
0.1 1.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.2 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 0.3 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 1.5 GO:0008092 cytoskeletal protein binding(GO:0008092)
0.0 0.1 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 0.2 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.2 GO:0033218 amide binding(GO:0033218) peptide binding(GO:0042277)
0.0 0.1 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.2 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0 0.1 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.2 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.0 GO:0000403 Y-form DNA binding(GO:0000403)
0.0 0.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.2 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.2 GO:0003678 DNA helicase activity(GO:0003678)
0.0 0.1 GO:0008198 ferrous iron binding(GO:0008198)
0.0 0.8 GO:0016757 transferase activity, transferring glycosyl groups(GO:0016757)
0.0 0.0 GO:0070569 uridylyltransferase activity(GO:0070569)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.9 PID SHP2 PATHWAY SHP2 signaling
0.6 2.5 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.3 0.9 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.3 2.8 PID ATR PATHWAY ATR signaling pathway
0.2 0.6 PID E2F PATHWAY E2F transcription factor network
0.2 0.4 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.2 0.6 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.2 0.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 0.3 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 0.2 PID MYC PATHWAY C-MYC pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 19.0 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
1.8 5.5 REACTOME SIGNALLING TO ERKS Genes involved in Signalling to ERKs
1.3 5.3 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
1.0 16.7 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.7 1.4 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.7 4.6 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.6 2.3 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.5 3.2 REACTOME PROTEIN FOLDING Genes involved in Protein folding
0.4 1.3 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.4 1.3 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.4 1.2 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.4 1.1 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.4 0.7 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.3 1.6 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.2 0.5 REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION Genes involved in Platelet activation, signaling and aggregation
0.2 1.1 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 0.6 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.1 0.4 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 1.3 REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION Genes involved in Post-translational protein modification
0.1 0.5 REACTOME RNA POL II PRE TRANSCRIPTION EVENTS Genes involved in RNA Polymerase II Pre-transcription Events
0.0 0.4 REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS Genes involved in Activation of ATR in response to replication stress
0.0 15.3 REACTOME GLYCOSAMINOGLYCAN METABOLISM Genes involved in Glycosaminoglycan metabolism