Results for RGT1
Z-value: 2.31
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Transcription factors associated with RGT1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
RGT1
|
S000001521 | Glucose-responsive transcription factor |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YFR055W Show fit | 74.89 |
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner |
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| YFR056C Show fit | 67.27 |
Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W |
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| YHR094C Show fit | 52.07 |
Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting |
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| YKR075C Show fit | 34.26 |
Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS |
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| YDR345C Show fit | 31.80 |
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions |
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| YLR154C Show fit | 24.95 |
Ribonuclease H2 subunit, required for RNase H2 activity |
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| YGL209W Show fit | 21.29 |
Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter |
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| YDR033W Show fit | 20.23 |
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p |
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| YLR154W-B Show fit | 19.83 |
Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand |
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| YLR154W-A Show fit | 19.03 |
Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand |
Network of associatons between targets according to the STRING database.
First level regulatory network of RGT1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 131.6 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 24.8 | 74.5 | GO:0000098 | sulfur amino acid catabolic process(GO:0000098) |
| 5.2 | 36.3 | GO:0043137 | DNA replication, removal of RNA primer(GO:0043137) |
| 2.7 | 29.2 | GO:0015758 | glucose transport(GO:0015758) |
| 6.4 | 25.6 | GO:1900436 | filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436) |
| 0.9 | 19.9 | GO:0006096 | glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757) |
| 0.2 | 19.8 | GO:0006364 | rRNA processing(GO:0006364) |
| 3.9 | 19.5 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
| 0.3 | 19.5 | GO:0016311 | dephosphorylation(GO:0016311) |
| 2.3 | 15.9 | GO:0010696 | positive regulation of spindle pole body separation(GO:0010696) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 94.2 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.9 | 54.4 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.3 | 44.8 | GO:0005933 | cellular bud(GO:0005933) |
| 12.0 | 36.0 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.8 | 31.3 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.1 | 31.0 | GO:0005886 | plasma membrane(GO:0005886) |
| 0.3 | 17.8 | GO:0030684 | preribosome(GO:0030684) |
| 1.1 | 13.8 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 0.1 | 13.0 | GO:0005730 | nucleolus(GO:0005730) |
| 0.7 | 12.2 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 148.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 10.1 | 60.5 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 11.3 | 45.2 | GO:0015146 | pentose transmembrane transporter activity(GO:0015146) |
| 9.2 | 36.8 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 1.7 | 25.5 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.7 | 19.8 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 1.8 | 17.9 | GO:0015578 | fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578) |
| 0.9 | 16.7 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.6 | 16.1 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 4.9 | 14.6 | GO:0003938 | IMP dehydrogenase activity(GO:0003938) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 4.9 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.3 | 2.8 | PID ATR PATHWAY | ATR signaling pathway |
| 0.6 | 2.5 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.3 | 0.9 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.2 | 0.6 | PID E2F PATHWAY | E2F transcription factor network |
| 0.2 | 0.6 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.2 | 0.5 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 0.4 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.2 | 0.3 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 0.2 | PID MYC PATHWAY | C-MYC pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 19.0 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 1.0 | 16.7 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 0.0 | 15.3 | REACTOME GLYCOSAMINOGLYCAN METABOLISM | Genes involved in Glycosaminoglycan metabolism |
| 1.8 | 5.5 | REACTOME SIGNALLING TO ERKS | Genes involved in Signalling to ERKs |
| 1.3 | 5.3 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.7 | 4.6 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.5 | 3.2 | REACTOME PROTEIN FOLDING | Genes involved in Protein folding |
| 0.6 | 2.3 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.3 | 1.6 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.7 | 1.4 | REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |