Results for RGM1

Z-value: 0.91

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Transcription factors associated with RGM1

Gene Symbol Gene ID Gene Info
S000004794 Putative zinc finger DNA binding transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of RGM1 motif

Sorted Z-values of RGM1 motif

Promoter Log-likelihood Transcript Gene Gene Info
YMR107W 17.41 Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YMR175W 13.70 Protein of unknown function whose expression is induced by osmotic stress
YOL052C-A 10.79 Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses
YKL217W 9.80 Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YNR034W-A 9.53 Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YHR096C 8.88 Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YOR393W 8.31 Protein of unknown function, has similarity to enolases
YEL039C 7.87 Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YKL026C 7.64 Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YPL230W 7.53 Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in protein folding, ATP binding, and cell wall biosynthesis
YBR072W 7.42 Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YIL057C 7.38 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YOR348C 7.25 Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YKL163W 7.24 O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YOL084W 7.20 Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YGR243W 7.20 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YIL099W 6.75 Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
YOR100C 6.58 Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YDR277C 6.43 Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YMR105C 6.25 Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase
YGR087C 6.00 Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YLR377C 5.99 Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YMR174C 5.64 Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact
YER150W 5.62 GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YDR343C 5.54 High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YNL117W 5.45 Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YAL061W 5.38 Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; BDH2 is an essential gene
YIL136W 5.37 Protein of unknown function, major constituent of the mitochondrial outer membrane; located on the outer (cytosolic) face of the outer membrane
YGR201C 5.31 Putative protein of unknown function
YPL036W 5.31 Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
YDR096W 5.28 JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1
YJR095W 5.19 Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YFL030W 5.13 Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YGR043C 5.05 Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity
YMR081C 5.04 Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YEL011W 5.02 Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YPR010C-A 4.99 Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YOL060C 4.99 Protein required for normal mitochondrial morphology, has similarity to hemolysins
YHR139C 4.92 Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YLR312C 4.86 Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YIL101C 4.86 Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate
YGR088W 4.82 Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YOR391C 4.80 Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease
YAL034C 4.77 Non-essential protein of unknown function
YDR342C 4.75 High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YHL040C 4.72 Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores
YPR026W 4.66 Acid trehalase required for utilization of extracellular trehalose
YGR256W 4.63 6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone
YDR171W 4.60 Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock
YBL015W 4.59 Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YFR053C 4.58 Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YAL054C 4.51 Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YML042W 4.48 Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
YCR005C 4.44 Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YJR115W 4.36 Putative protein of unknown function
YMR206W 4.33 Putative protein of unknown function; YMR206W is not an essential gene
YKL044W 4.30 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL222C 4.30 Integral membrane protein localized to mitochondria (untagged protein) and eisosomes, immobile patches at the cortex associated with endocytosis; sporulation and sphingolipid content are altered in mutants; has homologs SUR7 and YNL194C
YMR169C 4.29 Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose
YPL223C 4.28 Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YLR149C 4.28 Putative protein of unknown function; YLR149C is not an essential gene
YCR021C 4.23 Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YPL054W 4.21 Zinc-finger protein of unknown function
YMR194C-B 4.16 Putative protein of unknown function
YOR031W 4.15 Copper-binding metallothionein, required for wild-type copper resistance
YML089C 4.07 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YDR406W 4.00 Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
YPR027C 3.99 Putative protein of unknown function
YDR119W-A 3.98 Putative protein of unknown function
YOL085W-A 3.94 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YOL085C
YFR017C 3.91 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene
YIL100C-A 3.89 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL085W 3.86 Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
YBR117C 3.82 Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YNL194C 3.81 Integral membrane protein localized to eisosomes; sporulation and plasma membrane sphingolipid content are altered in mutants; has homologs SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YDL218W 3.78 Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions
YBR230C 3.77 Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron
YDL204W 3.76 Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily
YLR327C 3.72 Protein of unknown function that associates with ribosomes
YPR151C 3.62 Mitochondrial protein required for degradation of unstable forms of cytochrome c
YHL021C 3.61 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YAR035W 3.59 Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
YGR248W 3.58 6-phosphogluconolactonase with similarity to Sol3p
YDL169C 3.55 Protein of unknown function, transcript accumulates in response to any combination of stress conditions
YBR147W 3.53 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays fluconazole resistance and suppresses cdc13-1 temperature sensitivity
YIL100W 3.53 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A
YJL133C-A 3.52 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR178C 3.50 Carboxypeptidase Y inhibitor, function requires acetylation by the NatB N-terminal acetyltransferase; phosphatidylethanolamine-binding protein involved in protein kinase A signaling pathway
YPL186C 3.50 Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope
YER065C 3.48 Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YBR201C-A 3.47 Putative protein of unknown function
YKL148C 3.47 Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YCL048W-A 3.46 Putative protein of unknown function
YKL043W 3.44 Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate
YKR097W 3.42 Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YGR067C 3.40 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YER103W 3.40 Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation
YKL031W 3.39 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YPL017C 3.32 Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family, required for accurate meiotic chromosome segregation; null mutant displays increased levels of spontaneous Rad52 foci
YPL185W 3.30 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
YER067W 3.27 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YER067W is not an essential gene
YDR536W 3.20 Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YPL247C 3.09 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; YPL247C is not an essential gene
YBL049W 3.07 Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase
YDR070C 3.01 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR438W 2.99 L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive
YLR295C 2.98 Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YHR087W 2.94 Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity
YJR096W 2.94 Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YAR053W 2.91 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR297W 2.91 Vacuolar carboxypeptidase Y (proteinase C), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family
YBR214W 2.90 One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein, which genetic studies have implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis
YNL160W 2.86 Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p
YJR048W 2.85 Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YLR296W 2.82 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIL155C 2.79 Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner
YPR036W-A 2.78 Protein of unknown function; transcription is regulated by Pdr1p
YFR052C-A 2.75 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR247W 2.69 Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p
YMR195W 2.65 Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
YLR437C-A 2.64 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CAR2/YLR438W
YIL162W 2.62 Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YIL045W 2.62 Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase
YDR542W 2.61 Hypothetical protein
YJL116C 2.61 Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YEL008W 2.58 Hypothetical protein predicted to be involved in metabolism
YMR250W 2.58 Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress
YKL109W 2.57 Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YPL240C 2.57 Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
YAL062W 2.56 NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YNL200C 2.53 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNL036W 2.50 Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway
YMR251W 2.49 Omega class glutathione transferase; putative cytosolic localization
YJL103C 2.48 Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis
YPR127W 2.47 Putative protein of unknown function; expression is activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YLR258W 2.47 Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase
YDR043C 2.45 Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YML100W 2.45 Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose, homologous to Tps3p and may share function
YBL045C 2.44 Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain
YOR374W 2.43 Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
YLL053C 2.42 Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YEL070W 2.41 Deletion suppressor of mpt5 mutation
YPR015C 2.40 Putative protein of unknown function
YDL004W 2.40 Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YPR184W 2.39 Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria
YIL125W 2.38 Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA
YMR244W 2.34 Putative protein of unknown function
YEL009C 2.34 Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YNL305C 2.31 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL305C is not an essential gene
YML090W 2.29 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YML128C 2.29 Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated
YKL107W 2.26 Putative protein of unknown function
YDR541C 2.25 Putative dihydrokaempferol 4-reductase
YDL214C 2.24 Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
YDR258C 2.24 Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; prevents the aggregation of misfolded matrix proteins; component of the mitochondrial proteolysis system
YOL047C 2.23 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YGL096W 2.22 Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p
YIR027C 2.22 Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression
YKR102W 2.20 Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YBL078C 2.19 Conserved protein that is a component of autophagosomes and Cvt vesicles; undergoes C-terminal conjugation to phosphatidylethanolamine (PE), Atg8p-PE is anchored to membranes and may mediate membrane fusion during autophagosome formation
YAR060C 2.17 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL089W 2.17 C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus
YOR066W 2.16 Activator of G1-specific transcription factors, MBF and SBF, that regulates both the timing of G1-specific gene transcription, and cell cycle initiation; potential Cdc28p substrate
YMR165C 2.16 Mg2+-dependent phosphatidate (PA) phosphatase, catalyzes the dephosphorylation of PA to yield diacylglycerol and Pi, responsible for de novo lipid synthesis; homologous to mammalian lipin 1
YPL262W 2.15 Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation; phosphorylated in mitochondria
YLL041C 2.14 Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YOL082W 2.14 Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; recognizes cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) and delivers them to the preautophagosomal structure for packaging into Cvt vesicles
YLL026W 2.14 Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation
YOR392W 2.13 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; gene expression induced by heat
YER084W 2.13 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR382W 2.12 Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YJL141C 2.12 Serine-threonine protein kinase that is part of a glucose-sensing system involved in growth control in response to glucose availability; translocates from the cytoplasm to the nucleus and phosphorylates Pop2p in response to a glucose signal
YNL322C 2.10 Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
YLR356W 2.09 Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YPR013C 2.09 Putative zinc finger protein; YPR013C is not an essential gene
YPL015C 2.07 Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro
YLL052C 2.07 Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YER088C 2.07 Protein of unknown function, involved in telomeric gene silencing and filamentation
YKR034W 2.06 Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Deh1p
YNL144C 2.06 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YAR050W 2.05 Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YNL180C 2.05 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
YAL039C 2.05 Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YDL210W 2.04 Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YHR001W-A 2.04 Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain
YOL081W 2.03 GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin
YJL067W 2.02 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR256C 2.01 Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YOR178C 2.01 Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YLL055W 2.01 High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
YKL103C 2.00 Vacuolar aminopeptidase, often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway
YIL017C 1.99 Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm
YAL005C 1.99 ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall
YJL144W 1.97 Cytoplasmic hydrophilin of unknown function, possibly involved in the dessication response; expression induced by osmotic stress, starvation and during stationary phase; GFP-fusion protein is induced by the DNA-damaging agent MMS
YOR346W 1.97 Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YPR007C 1.97 Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p
YPL135W 1.97 Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable
YEL009C-A 1.96 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL115C 1.96 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
YOL154W 1.94 Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH

Network of associatons between targets according to the STRING database.

First level regulatory network of RGM1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 17.5 GO:0006848 pyruvate transport(GO:0006848)
3.5 10.5 GO:0052547 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
3.1 12.3 GO:0071462 response to water(GO:0009415) cellular response to water stimulus(GO:0071462)
2.7 8.1 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
2.5 7.5 GO:0032780 negative regulation of ATPase activity(GO:0032780)
2.2 10.8 GO:0005980 glycogen catabolic process(GO:0005980)
2.1 4.2 GO:0006740 NADPH regeneration(GO:0006740)
2.1 6.2 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
2.1 6.2 GO:0061416 regulation of transcription from RNA polymerase II promoter in response to salt stress(GO:0061416)
2.1 8.2 GO:0015804 neutral amino acid transport(GO:0015804)
1.9 5.7 GO:0005993 trehalose catabolic process(GO:0005993)
1.9 5.7 GO:0006545 glycine biosynthetic process(GO:0006545)
1.9 18.8 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
1.8 8.8 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
1.8 5.3 GO:0043335 protein unfolding(GO:0043335)
1.7 15.6 GO:0006097 glyoxylate cycle(GO:0006097)
1.7 1.7 GO:0046487 glyoxylate metabolic process(GO:0046487)
1.6 4.7 GO:0015740 C4-dicarboxylate transport(GO:0015740)
1.5 6.1 GO:0046323 glucose import(GO:0046323)
1.5 7.4 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
1.5 2.9 GO:0061414 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
1.4 7.2 GO:0006083 acetate metabolic process(GO:0006083)
1.4 5.5 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
1.3 16.8 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
1.3 5.1 GO:0006598 polyamine catabolic process(GO:0006598)
1.3 8.8 GO:0015758 glucose transport(GO:0015758)
1.3 6.3 GO:0034486 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
1.2 4.9 GO:0006482 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
1.2 7.0 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
1.1 3.4 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
1.1 9.0 GO:0015891 siderophore transport(GO:0015891)
1.0 4.2 GO:0071467 cellular response to pH(GO:0071467)
1.0 15.3 GO:0005978 glycogen biosynthetic process(GO:0005978)
1.0 2.0 GO:0045980 negative regulation of nucleotide metabolic process(GO:0045980)
1.0 3.9 GO:0006527 arginine catabolic process(GO:0006527)
1.0 3.9 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
1.0 2.9 GO:0072488 ammonium transmembrane transport(GO:0072488)
1.0 2.9 GO:0019748 secondary metabolic process(GO:0019748)
1.0 15.3 GO:0006754 ATP biosynthetic process(GO:0006754)
0.9 4.7 GO:0019405 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.9 2.6 GO:0030149 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.9 2.6 GO:0006538 glutamate catabolic process(GO:0006538)
0.9 3.4 GO:0015976 carbon utilization(GO:0015976)
0.9 1.7 GO:0006102 isocitrate metabolic process(GO:0006102)
0.8 3.8 GO:0043954 cellular component maintenance(GO:0043954)
0.8 2.3 GO:0031135 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.8 6.8 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.7 2.9 GO:1903137 inactivation of MAPK activity involved in cell wall organization or biogenesis(GO:0000200) regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903137) negative regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903138) negative regulation of cell wall organization or biogenesis(GO:1903339)
0.7 2.1 GO:0006003 fructose metabolic process(GO:0006000) fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.7 1.4 GO:0001315 age-dependent response to reactive oxygen species(GO:0001315) cellular age-dependent response to reactive oxygen species(GO:0072353)
0.7 2.1 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.7 2.0 GO:0018063 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.7 1.3 GO:0006108 malate metabolic process(GO:0006108)
0.7 2.0 GO:0042126 nitrate metabolic process(GO:0042126) nitrate assimilation(GO:0042128)
0.7 8.5 GO:0008645 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.6 5.7 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.6 4.4 GO:0030026 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.6 2.5 GO:0016242 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.6 2.5 GO:0015793 glycerol transport(GO:0015793)
0.6 2.4 GO:0046185 aldehyde catabolic process(GO:0046185)
0.6 6.0 GO:0006119 oxidative phosphorylation(GO:0006119)
0.6 9.9 GO:0006094 gluconeogenesis(GO:0006094)
0.6 2.3 GO:0019566 arabinose metabolic process(GO:0019566) arabinose catabolic process(GO:0019568)
0.6 0.6 GO:0001080 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
0.5 1.6 GO:0090630 activation of GTPase activity(GO:0090630)
0.5 2.1 GO:0034389 lipid particle organization(GO:0034389)
0.5 0.9 GO:0001306 age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.5 0.9 GO:0051352 negative regulation of ligase activity(GO:0051352) negative regulation of ubiquitin-protein transferase activity(GO:0051444)
0.4 0.9 GO:0052652 cAMP biosynthetic process(GO:0006171) cyclic nucleotide biosynthetic process(GO:0009190) cyclic purine nucleotide metabolic process(GO:0052652)
0.4 1.7 GO:0015847 putrescine transport(GO:0015847)
0.4 3.0 GO:0006101 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101)
0.4 3.4 GO:0005985 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.4 1.3 GO:0009107 lipoate metabolic process(GO:0009106) lipoate biosynthetic process(GO:0009107)
0.4 0.8 GO:0090153 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.4 9.6 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.4 0.4 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.4 0.8 GO:0019543 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
0.4 1.2 GO:0009450 gamma-aminobutyric acid metabolic process(GO:0009448) gamma-aminobutyric acid catabolic process(GO:0009450)
0.4 1.2 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.4 6.3 GO:0042724 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.4 4.5 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.4 0.4 GO:1900544 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.4 0.7 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.4 2.2 GO:0000256 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256) cellular amide catabolic process(GO:0043605)
0.4 5.7 GO:0001101 response to acid chemical(GO:0001101)
0.4 4.6 GO:0007135 meiosis II(GO:0007135) meiotic sister chromatid segregation(GO:0045144)
0.3 0.7 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.3 1.7 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.3 1.3 GO:0015886 heme transport(GO:0015886)
0.3 1.3 GO:0008053 mitochondrial fusion(GO:0008053)
0.3 1.9 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.3 1.5 GO:0006012 galactose metabolic process(GO:0006012)
0.3 0.3 GO:0034224 cellular response to zinc ion starvation(GO:0034224) regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation(GO:0034225)
0.3 1.2 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.3 4.1 GO:0006749 glutathione metabolic process(GO:0006749)
0.3 0.9 GO:2000197 regulation of mRNA export from nucleus(GO:0010793) regulation of nucleobase-containing compound transport(GO:0032239) regulation of RNA export from nucleus(GO:0046831) regulation of ribonucleoprotein complex localization(GO:2000197)
0.3 0.9 GO:0070583 spore membrane bending pathway(GO:0070583)
0.3 1.7 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.3 1.4 GO:0046931 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.3 3.6 GO:0006165 nucleoside diphosphate phosphorylation(GO:0006165)
0.3 2.4 GO:0046686 response to cadmium ion(GO:0046686)
0.3 0.8 GO:0000304 response to singlet oxygen(GO:0000304)
0.3 1.0 GO:0043388 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
0.3 0.3 GO:0042732 D-xylose metabolic process(GO:0042732)
0.2 0.5 GO:0042148 strand invasion(GO:0042148)
0.2 0.2 GO:0072350 tricarboxylic acid metabolic process(GO:0072350)
0.2 8.5 GO:0009060 aerobic respiration(GO:0009060)
0.2 2.4 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.2 2.1 GO:0070987 error-free translesion synthesis(GO:0070987)
0.2 1.2 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.2 0.9 GO:1903829 positive regulation of protein localization to nucleus(GO:1900182) positive regulation of cellular protein localization(GO:1903829)
0.2 1.2 GO:0000023 maltose metabolic process(GO:0000023)
0.2 0.9 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.2 0.5 GO:0008272 sulfate transport(GO:0008272)
0.2 1.8 GO:0006829 zinc II ion transport(GO:0006829)
0.2 0.5 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.2 3.6 GO:0042493 response to drug(GO:0042493)
0.2 1.7 GO:0061188 negative regulation of chromatin silencing at rDNA(GO:0061188)
0.2 0.6 GO:0032077 positive regulation of deoxyribonuclease activity(GO:0032077) positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.2 0.6 GO:0010133 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
0.2 2.9 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.2 0.6 GO:0071281 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.2 1.0 GO:0051654 establishment of mitochondrion localization(GO:0051654)
0.2 0.8 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.2 1.4 GO:0034762 regulation of transmembrane transport(GO:0034762)
0.2 0.6 GO:0051503 adenine nucleotide transport(GO:0051503)
0.2 1.6 GO:0018345 protein palmitoylation(GO:0018345)
0.2 2.3 GO:0016925 protein sumoylation(GO:0016925)
0.2 1.1 GO:0006855 drug transmembrane transport(GO:0006855)
0.2 0.9 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.2 1.3 GO:0009306 protein secretion(GO:0009306)
0.2 1.2 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.2 2.1 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.2 0.2 GO:2000219 positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter(GO:0036095) positive regulation of invasive growth in response to glucose limitation(GO:2000219)
0.2 1.4 GO:0006638 neutral lipid metabolic process(GO:0006638) acylglycerol metabolic process(GO:0006639) triglyceride metabolic process(GO:0006641)
0.2 0.5 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.2 0.3 GO:0015680 intracellular copper ion transport(GO:0015680)
0.2 6.5 GO:0070726 cell wall assembly(GO:0070726)
0.2 9.5 GO:0007031 peroxisome organization(GO:0007031)
0.2 0.3 GO:0006624 vacuolar protein processing(GO:0006624)
0.2 1.8 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.2 2.0 GO:0032258 CVT pathway(GO:0032258)
0.2 1.3 GO:0006874 cellular calcium ion homeostasis(GO:0006874) calcium ion homeostasis(GO:0055074)
0.2 0.8 GO:0000196 MAPK cascade involved in cell wall organization or biogenesis(GO:0000196)
0.2 0.2 GO:0071629 cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071629)
0.2 0.8 GO:0006265 DNA topological change(GO:0006265)
0.1 0.4 GO:0032056 positive regulation of translation in response to stress(GO:0032056)
0.1 0.4 GO:0032365 intracellular lipid transport(GO:0032365)
0.1 0.7 GO:0005977 glycogen metabolic process(GO:0005977) energy reserve metabolic process(GO:0006112)
0.1 0.1 GO:0042816 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.1 1.4 GO:0000767 cell morphogenesis involved in conjugation with cellular fusion(GO:0000753) cell morphogenesis involved in conjugation(GO:0000767)
0.1 0.8 GO:0071709 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.1 0.1 GO:0051606 detection of chemical stimulus(GO:0009593) detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) detection of stimulus(GO:0051606)
0.1 2.6 GO:0016579 protein deubiquitination(GO:0016579)
0.1 0.5 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) negative regulation of actin nucleation(GO:0051126)
0.1 0.7 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.1 0.9 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.1 0.3 GO:0006311 meiotic gene conversion(GO:0006311)
0.1 0.2 GO:0051303 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.1 0.7 GO:0051058 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.1 1.8 GO:0006312 mitotic recombination(GO:0006312)
0.1 0.5 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.1 1.6 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968) cellular response to unfolded protein(GO:0034620)
0.1 4.0 GO:0030437 ascospore formation(GO:0030437) cell development(GO:0048468)
0.1 0.3 GO:0042407 cristae formation(GO:0042407)
0.1 0.7 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.1 0.3 GO:0045894 regulation of mating-type specific transcription from RNA polymerase II promoter(GO:0001196) negative regulation of mating-type specific transcription from RNA polymerase II promoter(GO:0001198) negative regulation of mating-type specific transcription, DNA-templated(GO:0045894)
0.1 0.6 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.1 0.2 GO:0036257 multivesicular body organization(GO:0036257)
0.1 0.5 GO:0070096 mitochondrial outer membrane translocase complex assembly(GO:0070096)
0.1 2.0 GO:0022900 electron transport chain(GO:0022900)
0.1 4.3 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.1 0.6 GO:1901658 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.1 0.5 GO:0043409 negative regulation of MAPK cascade(GO:0043409)
0.1 0.4 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.1 0.1 GO:0015691 cadmium ion transport(GO:0015691)
0.1 0.8 GO:0015851 nucleobase transport(GO:0015851)
0.1 0.4 GO:0043462 positive regulation of ATPase activity(GO:0032781) regulation of ATPase activity(GO:0043462)
0.1 0.3 GO:0090399 replicative senescence(GO:0090399)
0.1 0.7 GO:0019856 pyrimidine nucleobase biosynthetic process(GO:0019856)
0.1 0.8 GO:0006826 iron ion transport(GO:0006826)
0.1 0.3 GO:0034503 protein localization to nucleolar rDNA repeats(GO:0034503)
0.1 0.3 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.1 0.2 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.1 0.2 GO:0043687 C-terminal protein amino acid modification(GO:0018410) post-translational protein modification(GO:0043687)
0.1 0.1 GO:0019692 deoxyribose phosphate metabolic process(GO:0019692)
0.1 0.4 GO:0019722 calcium-mediated signaling(GO:0019722)
0.1 1.2 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 0.1 GO:0050685 positive regulation of mRNA processing(GO:0050685)
0.1 0.1 GO:0035494 SNARE complex disassembly(GO:0035494)
0.1 0.7 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.1 0.9 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413) peptidyl-proline modification(GO:0018208)
0.1 0.1 GO:0006089 lactate metabolic process(GO:0006089)
0.1 0.1 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.1 0.1 GO:0031397 negative regulation of protein ubiquitination(GO:0031397) negative regulation of protein modification by small protein conjugation or removal(GO:1903321)
0.1 0.3 GO:0045910 negative regulation of DNA recombination(GO:0045910)
0.1 0.3 GO:0006078 (1->6)-beta-D-glucan biosynthetic process(GO:0006078) beta-glucan biosynthetic process(GO:0051274)
0.1 0.7 GO:0051447 negative regulation of meiotic nuclear division(GO:0045835) negative regulation of meiotic cell cycle(GO:0051447)
0.1 0.2 GO:0061393 positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress(GO:0061393)
0.1 0.1 GO:0051228 mitotic spindle disassembly(GO:0051228) spindle disassembly(GO:0051230)
0.1 0.1 GO:0051098 regulation of binding(GO:0051098)
0.1 0.4 GO:0006465 signal peptide processing(GO:0006465)
0.1 0.1 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.1 0.2 GO:0001111 promoter clearance during DNA-templated transcription(GO:0001109) promoter clearance from RNA polymerase II promoter(GO:0001111)
0.1 0.4 GO:0072348 sulfur compound transport(GO:0072348)
0.1 0.1 GO:0008216 spermidine metabolic process(GO:0008216)
0.1 0.2 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.1 0.3 GO:0000338 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.1 0.3 GO:0042537 benzene-containing compound metabolic process(GO:0042537)
0.1 0.2 GO:0007532 regulation of mating-type specific transcription, DNA-templated(GO:0007532)
0.0 0.1 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.2 GO:2000105 positive regulation of DNA-dependent DNA replication(GO:2000105)
0.0 0.1 GO:0032186 cellular bud neck septin ring organization(GO:0032186)
0.0 0.2 GO:0032978 protein insertion into membrane from inner side(GO:0032978) protein insertion into mitochondrial membrane from inner side(GO:0032979)
0.0 0.2 GO:0055069 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.0 0.0 GO:0034086 maintenance of sister chromatid cohesion(GO:0034086)
0.0 0.0 GO:0030007 cellular potassium ion homeostasis(GO:0030007) potassium ion homeostasis(GO:0055075)
0.0 0.2 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.0 0.2 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.0 0.6 GO:0016237 membrane invagination(GO:0010324) lysosomal microautophagy(GO:0016237) single-organism membrane invagination(GO:1902534)
0.0 0.1 GO:0070475 rRNA base methylation(GO:0070475)
0.0 0.5 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 1.2 GO:0006661 phosphatidylinositol biosynthetic process(GO:0006661)
0.0 0.1 GO:0006531 aspartate metabolic process(GO:0006531)
0.0 0.3 GO:0034087 establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087)
0.0 0.3 GO:1901264 carbohydrate derivative transport(GO:1901264)
0.0 0.2 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.3 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.0 0.3 GO:0007121 bipolar cellular bud site selection(GO:0007121)
0.0 0.5 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.1 GO:0035753 maintenance of DNA trinucleotide repeats(GO:0035753)
0.0 0.3 GO:0046854 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.1 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.2 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.0 0.4 GO:0000209 protein polyubiquitination(GO:0000209)
0.0 0.3 GO:0001300 chronological cell aging(GO:0001300)
0.0 0.1 GO:0035967 cellular response to topologically incorrect protein(GO:0035967)
0.0 0.4 GO:0015914 phospholipid transport(GO:0015914)
0.0 0.1 GO:0070932 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0 0.3 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.2 GO:0009263 deoxyribonucleotide metabolic process(GO:0009262) deoxyribonucleotide biosynthetic process(GO:0009263)
0.0 0.0 GO:0043068 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.0 0.1 GO:0009102 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.0 0.1 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.0 0.1 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.0 GO:0071168 protein localization to chromatin(GO:0071168)
0.0 0.0 GO:0060962 regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060962)
0.0 0.1 GO:0048279 vesicle fusion with endoplasmic reticulum(GO:0048279)
0.0 0.0 GO:0009187 cyclic nucleotide metabolic process(GO:0009187)
0.0 0.0 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491)
0.0 0.0 GO:0017004 cytochrome complex assembly(GO:0017004)
0.0 0.1 GO:0090114 COPII-coated vesicle budding(GO:0090114)
0.0 0.0 GO:0006074 (1->3)-beta-D-glucan metabolic process(GO:0006074)
0.0 0.0 GO:0030491 heteroduplex formation(GO:0030491)
0.0 0.1 GO:0009410 response to xenobiotic stimulus(GO:0009410)
0.0 0.0 GO:0006546 glycine catabolic process(GO:0006546)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 8.9 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
1.8 7.0 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
1.5 7.4 GO:0045257 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
1.5 4.4 GO:0005756 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
1.3 3.8 GO:0031166 integral component of vacuolar membrane(GO:0031166)
1.2 7.3 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
1.2 10.5 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
1.1 1.1 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
1.1 14.1 GO:0070469 respiratory chain(GO:0070469)
0.9 7.3 GO:0042597 periplasmic space(GO:0042597)
0.9 3.6 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.9 7.8 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.8 5.6 GO:0034657 GID complex(GO:0034657)
0.8 14.1 GO:0031307 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.7 1.4 GO:0030061 mitochondrial crista(GO:0030061)
0.6 1.3 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.6 6.0 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259)
0.6 4.7 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.6 2.8 GO:0072379 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.5 2.0 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.5 1.5 GO:0001400 mating projection base(GO:0001400)
0.5 2.9 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.5 5.2 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.5 1.4 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.4 4.8 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.4 0.8 GO:0005775 vacuolar lumen(GO:0005775)
0.3 4.1 GO:0005619 ascospore wall(GO:0005619)
0.3 14.9 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.3 0.8 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.3 1.0 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.2 3.2 GO:0098552 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.2 0.7 GO:0032389 MutLalpha complex(GO:0032389)
0.2 11.2 GO:0031225 anchored component of membrane(GO:0031225)
0.2 36.2 GO:0000324 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.2 30.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.2 3.3 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.2 0.8 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.2 0.4 GO:0032126 eisosome(GO:0032126)
0.2 3.6 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.2 1.4 GO:0033101 cellular bud membrane(GO:0033101)
0.2 5.5 GO:0005576 extracellular region(GO:0005576)
0.2 1.2 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.2 2.6 GO:0033698 Rpd3L complex(GO:0033698)
0.2 0.7 GO:0033551 monopolin complex(GO:0033551)
0.2 0.5 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 0.4 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 0.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.6 GO:0005825 half bridge of spindle pole body(GO:0005825)
0.1 0.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 0.6 GO:0044233 ERMES complex(GO:0032865) ER-mitochondrion membrane contact site(GO:0044233)
0.1 0.3 GO:0009277 fungal-type cell wall(GO:0009277)
0.1 5.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 2.0 GO:0042763 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.1 0.6 GO:0034967 Set3 complex(GO:0034967)
0.1 57.6 GO:0005739 mitochondrion(GO:0005739)
0.1 2.5 GO:0019898 extrinsic component of membrane(GO:0019898)
0.1 0.4 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.1 0.6 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 0.5 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.1 0.6 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 0.4 GO:0005869 dynactin complex(GO:0005869)
0.1 0.4 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836) Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.1 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.1 0.7 GO:0090544 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.1 0.3 GO:0031262 Ndc80 complex(GO:0031262)
0.1 0.3 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.1 0.2 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.1 0.1 GO:0070822 Sin3-type complex(GO:0070822)
0.1 0.3 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.1 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.0 0.2 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.2 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 0.1 GO:0097196 Shu complex(GO:0097196)
0.0 0.1 GO:0070211 Snt2C complex(GO:0070211)
0.0 0.1 GO:0005784 Sec61 translocon complex(GO:0005784)
0.0 0.4 GO:0035267 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.6 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.1 GO:0032807 DNA ligase IV complex(GO:0032807)
0.0 0.1 GO:0005769 early endosome(GO:0005769)
0.0 0.2 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.3 GO:0000124 SAGA complex(GO:0000124)
0.0 0.1 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.0 0.1 GO:0071007 U2-type catalytic step 2 spliceosome(GO:0071007) catalytic step 2 spliceosome(GO:0071013)
0.0 0.1 GO:0000974 Prp19 complex(GO:0000974)
0.0 0.1 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.3 GO:0016592 mediator complex(GO:0016592)
0.0 0.2 GO:0005682 U5 snRNP(GO:0005682)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 10.5 GO:0030414 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
3.0 8.9 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
2.9 14.7 GO:0015295 solute:proton symporter activity(GO:0015295)
2.7 8.1 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
2.6 7.7 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
2.5 7.5 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
2.1 6.3 GO:0050136 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
2.0 6.1 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
1.9 5.7 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
1.8 7.1 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
1.6 6.5 GO:0005537 mannose binding(GO:0005537)
1.6 8.0 GO:0050308 sugar-phosphatase activity(GO:0050308)
1.6 4.7 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
1.5 4.6 GO:0016289 CoA hydrolase activity(GO:0016289)
1.5 4.5 GO:0016208 AMP binding(GO:0016208)
1.5 6.0 GO:0004396 hexokinase activity(GO:0004396)
1.5 7.4 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
1.4 5.6 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
1.4 5.5 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
1.4 5.4 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
1.3 7.8 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
1.3 7.7 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
1.3 5.1 GO:0042927 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
1.3 5.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
1.3 10.2 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
1.2 2.3 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.9 2.6 GO:0004575 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
0.9 7.0 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.9 14.8 GO:0020037 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.8 9.1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.8 3.2 GO:0004180 carboxypeptidase activity(GO:0004180)
0.8 2.4 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.8 3.9 GO:0008198 ferrous iron binding(GO:0008198)
0.8 10.7 GO:0005353 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.7 3.4 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.6 3.2 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.6 1.9 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.6 4.1 GO:0004364 glutathione transferase activity(GO:0004364)
0.6 1.2 GO:0015151 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.6 2.3 GO:0015386 potassium:proton antiporter activity(GO:0015386) potassium ion antiporter activity(GO:0022821)
0.6 2.2 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.5 1.9 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.5 1.9 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.5 1.4 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.4 2.7 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.4 3.9 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.4 0.4 GO:0051185 coenzyme transporter activity(GO:0051185)
0.4 2.1 GO:0050253 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.4 5.7 GO:0016831 carboxy-lyase activity(GO:0016831)
0.4 4.5 GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism(GO:0015662)
0.4 4.9 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.4 5.2 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.4 0.8 GO:0035591 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.4 2.3 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.4 3.1 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.4 0.4 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
0.4 7.2 GO:0016769 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.4 1.5 GO:0005346 purine ribonucleotide transmembrane transporter activity(GO:0005346) ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) purine nucleoside transmembrane transporter activity(GO:0015211) ADP transmembrane transporter activity(GO:0015217)
0.4 1.1 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.4 2.2 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.4 2.8 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.4 1.1 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.4 4.2 GO:0022838 substrate-specific channel activity(GO:0022838)
0.3 0.7 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
0.3 10.2 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.3 0.9 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.3 0.9 GO:0070569 uridylyltransferase activity(GO:0070569)
0.3 3.0 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.3 0.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.3 2.4 GO:0017136 NAD-dependent histone deacetylase activity(GO:0017136) NAD-dependent protein deacetylase activity(GO:0034979)
0.3 2.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.3 1.1 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.3 1.4 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.3 1.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.3 4.9 GO:0050661 NADP binding(GO:0050661)
0.3 20.6 GO:0051082 unfolded protein binding(GO:0051082)
0.3 1.3 GO:0017022 myosin binding(GO:0017022)
0.3 0.8 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.2 0.7 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
0.2 1.2 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.2 2.1 GO:0001083 transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083)
0.2 3.9 GO:0005507 copper ion binding(GO:0005507)
0.2 0.9 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
0.2 0.2 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.2 0.5 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.2 0.7 GO:0016872 intramolecular lyase activity(GO:0016872)
0.2 0.9 GO:0045118 azole transporter activity(GO:0045118)
0.2 2.2 GO:0035064 methylated histone binding(GO:0035064)
0.2 1.3 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.2 0.9 GO:0019776 Atg8 ligase activity(GO:0019776)
0.2 1.7 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.2 2.2 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 0.9 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
0.2 4.4 GO:0004857 enzyme inhibitor activity(GO:0004857)
0.2 0.8 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.2 0.6 GO:0000150 recombinase activity(GO:0000150)
0.2 0.2 GO:0019902 phosphatase binding(GO:0019902) protein phosphatase binding(GO:0019903)
0.2 1.7 GO:0015297 antiporter activity(GO:0015297)
0.2 2.0 GO:0038023 transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) transmembrane receptor activity(GO:0099600)
0.2 0.7 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.2 0.2 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.2 0.5 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.2 0.5 GO:0015294 solute:cation symporter activity(GO:0015294)
0.2 0.5 GO:0001091 RNA polymerase II basal transcription factor binding(GO:0001091)
0.1 0.4 GO:0016898 lactate dehydrogenase activity(GO:0004457) D-lactate dehydrogenase (cytochrome) activity(GO:0004458) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
0.1 0.4 GO:0008972 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.1 0.6 GO:0008169 C-methyltransferase activity(GO:0008169)
0.1 0.7 GO:0016830 carbon-carbon lyase activity(GO:0016830)
0.1 0.3 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 0.3 GO:0048029 monosaccharide binding(GO:0048029)
0.1 0.4 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.1 5.0 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.1 2.0 GO:0005057 receptor signaling protein activity(GO:0005057)
0.1 0.4 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.1 0.4 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.1 1.0 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 1.0 GO:0000293 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.1 3.9 GO:0043492 ATPase activity, coupled to movement of substances(GO:0043492)
0.1 0.4 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.1 0.5 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.1 0.4 GO:0019211 phosphatase activator activity(GO:0019211)
0.1 0.2 GO:0004738 pyruvate dehydrogenase activity(GO:0004738)
0.1 0.7 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.1 0.5 GO:0000400 four-way junction DNA binding(GO:0000400)
0.1 0.4 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.1 0.3 GO:0015293 symporter activity(GO:0015293)
0.1 0.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 0.3 GO:0055106 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106) ubiquitin-protein transferase activator activity(GO:0097027)
0.1 0.4 GO:0016782 transferase activity, transferring sulfur-containing groups(GO:0016782)
0.1 0.3 GO:0000772 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.1 0.2 GO:0008897 holo-[acyl-carrier-protein] synthase activity(GO:0008897)
0.1 1.1 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 0.2 GO:0070336 flap-structured DNA binding(GO:0070336)
0.1 0.3 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.1 1.3 GO:0036459 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 0.2 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.1 1.0 GO:0004527 exonuclease activity(GO:0004527)
0.1 0.2 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 1.5 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 0.2 GO:0008171 O-methyltransferase activity(GO:0008171)
0.1 0.4 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.1 0.2 GO:0046527 glucosyltransferase activity(GO:0046527)
0.1 0.6 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 0.7 GO:0045182 translation regulator activity(GO:0045182)
0.1 0.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.1 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.1 GO:0003840 gamma-glutamyltransferase activity(GO:0003840)
0.0 0.1 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.0 0.4 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.0 0.1 GO:0001139 transcription factor activity, core RNA polymerase II recruiting(GO:0001139)
0.0 0.6 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.4 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 0.6 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.2 GO:0016651 oxidoreductase activity, acting on NAD(P)H(GO:0016651)
0.0 0.1 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.0 0.3 GO:1901505 carbohydrate derivative transporter activity(GO:1901505)
0.0 0.3 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 0.0 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0 0.1 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)
0.0 0.1 GO:0005102 receptor binding(GO:0005102)
0.0 0.2 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.1 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.1 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.3 GO:0017171 serine hydrolase activity(GO:0017171)
0.0 0.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.1 GO:0015203 polyamine transmembrane transporter activity(GO:0015203)
0.0 0.2 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.3 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.0 0.1 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.0 0.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.1 GO:0052742 phosphatidylinositol kinase activity(GO:0052742)
0.0 0.1 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 0.1 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.1 GO:0001025 transcription factor activity, core RNA polymerase III binding(GO:0000995) RNA polymerase III transcription factor binding(GO:0001025) TFIIIB-type transcription factor activity(GO:0001026) TFIIIC-class transcription factor binding(GO:0001156)
0.0 0.2 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.0 0.4 GO:0022884 protein transmembrane transporter activity(GO:0008320) macromolecule transmembrane transporter activity(GO:0022884)
0.0 0.4 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.0 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.1 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.0 0.1 GO:0016859 peptidyl-prolyl cis-trans isomerase activity(GO:0003755) cis-trans isomerase activity(GO:0016859)
0.0 0.0 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.0 0.0 GO:0015216 purine nucleotide transmembrane transporter activity(GO:0015216)
0.0 0.1 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 7.3 PID IL4 2PATHWAY IL4-mediated signaling events
1.4 4.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
1.0 5.0 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.6 1.3 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.4 1.7 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.4 1.2 PID FOXO PATHWAY FoxO family signaling
0.4 2.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 0.1 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 0.3 PID P73PATHWAY p73 transcription factor network
0.1 0.5 PID PLK1 PATHWAY PLK1 signaling events
0.1 0.2 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 58.4 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.0 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.0 PID ATM PATHWAY ATM pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.7 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
1.4 15.9 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.7 2.0 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.4 0.7 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.3 1.4 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.3 1.0 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.2 0.6 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 1.4 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 0.1 REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION Genes involved in Platelet activation, signaling and aggregation
0.0 50.8 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.1 REACTOME APOPTOTIC EXECUTION PHASE Genes involved in Apoptotic execution phase
0.0 0.1 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.1 REACTOME MEIOSIS Genes involved in Meiosis