Results for RFX1
Z-value: 0.80
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Transcription factors associated with RFX1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
RFX1
|
S000004166 | Major transcriptional repressor of DNA-damage-regulated genes |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YFR055W Show fit | 8.44 |
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner |
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| YFR056C Show fit | 7.25 |
Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W |
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| YDR044W Show fit | 4.62 |
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p) |
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| YHR141C Show fit | 3.65 |
Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to rat L44; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus |
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| YNR001W-A Show fit | 3.41 |
Dubious open reading frame unlikely to encode a functional protein; identified by homology |
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| YGR108W Show fit | 3.29 |
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome |
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| YDL085C-A Show fit | 3.12 |
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus |
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| YOR063W Show fit | 3.04 |
Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus |
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| YOR315W Show fit | 3.01 |
Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate |
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| YOL086C Show fit | 2.90 |
Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway |
Network of associatons between targets according to the STRING database.
First level regulatory network of RFX1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 19.4 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 2.8 | 8.4 | GO:0000098 | sulfur amino acid catabolic process(GO:0000098) |
| 0.2 | 7.7 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 0.3 | 5.6 | GO:0051029 | rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029) |
| 0.8 | 5.5 | GO:0046501 | protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501) |
| 0.6 | 4.5 | GO:0043137 | DNA replication, removal of RNA primer(GO:0043137) |
| 0.4 | 3.9 | GO:0000947 | amino acid catabolic process to alcohol via Ehrlich pathway(GO:0000947) |
| 0.4 | 3.9 | GO:0007109 | obsolete cytokinesis, completion of separation(GO:0007109) |
| 0.1 | 3.8 | GO:0009266 | response to temperature stimulus(GO:0009266) |
| 0.9 | 3.6 | GO:0046898 | response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 24.3 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.2 | 12.6 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 5.7 | GO:0005933 | cellular bud(GO:0005933) |
| 1.5 | 4.5 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.1 | 4.3 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 0.0 | 4.3 | GO:0005730 | nucleolus(GO:0005730) |
| 0.1 | 4.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.2 | 3.9 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.2 | 2.9 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.9 | 2.7 | GO:0030428 | cell septum(GO:0030428) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 32.2 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.3 | 8.0 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 1.1 | 4.5 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 0.2 | 4.4 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 1.1 | 4.3 | GO:0016634 | oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634) |
| 0.6 | 3.9 | GO:0004022 | alcohol dehydrogenase (NAD) activity(GO:0004022) |
| 0.1 | 3.9 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.2 | 3.8 | GO:0016836 | hydro-lyase activity(GO:0016836) |
| 0.2 | 3.4 | GO:0042162 | telomeric DNA binding(GO:0042162) |
| 0.1 | 3.3 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.8 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 0.3 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 0.1 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 0.0 | 0.1 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 0.0 | PID ATM PATHWAY | ATM pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 7.8 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.4 | 1.3 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.2 | 1.2 | REACTOME GPCR LIGAND BINDING | Genes involved in GPCR ligand binding |
| 0.1 | 0.8 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.1 | 0.7 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 0.6 | REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 0.1 | 0.3 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.1 | 0.3 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.1 | 0.3 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.0 | 0.3 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |