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Results for RDS2

Z-value: 0.69

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Transcription factors associated with RDS2

Gene Symbol Gene ID Gene Info
RDS2
S000006054 Transcription factor involved in regulating gluconeogenesis

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RDS2YPL133C0.174.1e-01Click!

Activity profile of RDS2 motif

Sorted Z-values of RDS2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YDR536W 2.43
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YIR039C 2.28
YPS6
Putative GPI-anchored aspartic protease
YNL160W 2.27
YGP1
Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p
YDR343C 2.20
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YER065C 2.14
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YEL065W 2.12
SIT1
Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
YDR342C 2.11
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YER150W 2.06
SPI1
GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YEL008W 2.03 Hypothetical protein predicted to be involved in metabolism
YCR021C 2.00
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YDR032C 1.82
PST2
Protein with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJL045W 1.78 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YEL009C 1.62
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YOR343C 1.59 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YLR142W 1.52
PUT1
Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
YER103W 1.52
SSA4
Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation
YKL163W 1.51
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YKR097W 1.49
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YNL055C 1.49
POR1
Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated
YBR072W 1.42
HSP26
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YLR331C 1.38
JIP3
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
YLR332W 1.36
MID2
O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
YGR110W 1.36 Putative protein of unknown function; transcription is increased in response to genotoxic stress; plays a role in restricting Ty1 transposition
YER066W 1.36 Putative protein of unknown function; YER066W is not an essential gene
YPL017C 1.33
IRC15
Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family, required for accurate meiotic chromosome segregation; null mutant displays increased levels of spontaneous Rad52 foci
YNR002C 1.32
ATO2
Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p
YPR150W 1.28 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C
YLR327C 1.27
TMA10
Protein of unknown function that associates with ribosomes
YDR119W-A 1.23 Putative protein of unknown function
YPR013C 1.19 Putative zinc finger protein; YPR013C is not an essential gene
YBR222C 1.16
PCS60
Peroxisomal AMP-binding protein, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase
YAR023C 1.13 Putative integral membrane protein, member of DUP240 gene family
YGR256W 1.13
GND2
6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone
YNR073C 1.10 Putative mannitol dehydrogenase
YDL238C 1.07
GUD1
Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures
YFR053C 1.05
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YPR002W 1.03
PDH1
Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate
YPL134C 1.02
ODC1
Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation
YDR516C 1.01
EMI2
Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression is regulated by glucose-repression transcription factors Mig1/2p
YHL021C 1.00
AIM17
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YLR350W 0.99
ORM2
Evolutionarily conserved protein with similarity to Orm1p, required for resistance to agents that induce the unfolded protein response; human ortholog is located in the endoplasmic reticulum
YLR377C 0.95
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YAR027W 0.93
UIP3
Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family
YLR270W 0.91
DCS1
Non-essential hydrolase involved in mRNA decapping, may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; interacts with neutral trehalase Nth1p
YBR067C 0.89
TIP1
Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
YDR476C 0.88 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene
YLR122C 0.87 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YDL086W 0.84 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
YGL248W 0.84
PDE1
Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation
YHR211W 0.84
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YGL055W 0.83
OLE1
Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
YHL040C 0.81
ARN1
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores
YLR279W 0.80 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR250C 0.80 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YPR160W 0.79
GPH1
Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
YOL059W 0.78
GPD2
NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria
YDL182W 0.78
LYS20
Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys21p
YOL060C 0.78
MAM3
Protein required for normal mitochondrial morphology, has similarity to hemolysins
YLR252W 0.78 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SYM1, a mitochondrial protein involved in ethanol metabolism
YDR102C 0.78 Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index
YLR295C 0.78
ATP14
Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YNL194C 0.77 Integral membrane protein localized to eisosomes; sporulation and plasma membrane sphingolipid content are altered in mutants; has homologs SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YOL147C 0.76
PEX11
Peroxisomal membrane protein required for peroxisome proliferation and medium-chain fatty acid oxidation, most abundant protein in the peroxisomal membrane, regulated by Adr1p and Pip2p-Oaf1p, promoter contains ORE and UAS1-like elements
YER053C 0.76
PIC2
Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature
YDR031W 0.75
MIC14
Mitochondrial intermembrane space cysteine motif protein of 14 kDa
YGL053W 0.75
PRM8
Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family
YAR035W 0.74
YAT1
Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
YOL128C 0.74
YGK3
Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation
YML028W 0.73
TSA1
Thioredoxin peroxidase, acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype
YMR104C 0.73
YPK2
Protein kinase with similarityto serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK
YDR277C 0.73
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YPL224C 0.73
MMT2
Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p
YEL070W 0.72
DSF1
Deletion suppressor of mpt5 mutation
YDR103W 0.71
STE5
Pheromone-response scaffold protein; binds kinases Ste11p, Ste7p, and Fus3p to form a MAPK cascade complex that interacts with the plasma membrane, via a PH (pleckstrin homology) and PM/NLS domain, and with Ste4p-Ste18p, during signaling
YDL237W 0.71
LRC1
Putative protein of unknown function; YDL237W is not an essential gene; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YPR151C 0.69
SUE1
Mitochondrial protein required for degradation of unstable forms of cytochrome c
YLR123C 0.69 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YLR402W 0.68 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR034C 0.67
LYS14
Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
YPL274W 0.65
SAM3
High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p
YMR181C 0.65 Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); YMR181C is not an essential gene
YBR054W 0.65
YRO2
Putative protein of unknown function; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p
YPR023C 0.64
EAF3
Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition
YMR210W 0.64 Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
YLR403W 0.63
SFP1
Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
YHR145C 0.63 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR022C 0.62
CIS1
Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion
YOR072W-A 0.62 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR072W; originally identified by fungal homology and RT-PCR
YMR017W 0.61
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YGR244C 0.61
LSC2
Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate
YAL039C 0.60
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YLR296W 0.60 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YCR007C 0.60 Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YNL015W 0.60
PBI2
Cytosolic inhibitor of vacuolar proteinase B, required for efficient vacuole inheritance; with thioredoxin forms protein complex LMA1, which assists in priming SNARE molecules and promotes vacuole fusion
YKL028W 0.59
TFA1
TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening
YBR177C 0.58
EHT1
Acyl-coenzymeA:ethanol O-acyltransferase that plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane
YLR214W 0.58
FRE1
Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels
YJL213W 0.58 Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p
YJL161W 0.57
FMP33
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YIL042C 0.57
PKP1
Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p
YOL154W 0.56
ZPS1
Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
YDR442W 0.56 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER067C-A 0.56 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
YBL096C 0.56 Non-essential protein of unknown function
YMR182C 0.55
RGM1
Putative transcriptional repressor with proline-rich zinc fingers; overproduction impairs cell growth
YJR151C 0.54
DAN4
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YDR171W 0.54
HSP42
Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock
YLR259C 0.54
HSP60
Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated
YHR210C 0.54 Putative protein of unknown function; non-essential gene; highly expressed under anaeorbic conditions; sequence similarity to aldose 1-epimerases such as GAL10
YOR049C 0.53
RSB1
Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
YKL217W 0.53
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YPR007C 0.53
REC8
Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p
YPL201C 0.53
YIG1
Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol
YJL217W 0.52 Cytoplasmic protein of unknown function; expression induced by calcium shortage and via the copper sensing transciption factor Mac1p during conditons of copper deficiency; mRNA is cell cycle regulated, peaking in G1 phase
YMR206W 0.52 Putative protein of unknown function; YMR206W is not an essential gene
YGR087C 0.52
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YBL095W 0.52 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR148C 0.52
KGD2
Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
YDR313C 0.52
PIB1
RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain
YLR280C 0.52 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR105C 0.52
VID24
Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; involved in proteasome-dependent catabolite degradation of FBPase
YDR030C 0.52
RAD28
Protein involved in DNA repair, related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair
YNL074C 0.51
MLF3
Serine-rich protein of unknown function; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
YKR102W 0.51
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YPL015C 0.51
HST2
Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro
YDR234W 0.51
LYS4
Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway
YBL099W 0.50
ATP1
Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YLR342W 0.49
FKS1
Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling
YOR247W 0.49
SRL1
Mannoprotein that exhibits a tight association with the cell wall, required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants
YLR237W 0.49
THI7
Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
YLR047C 0.48
FRE8
Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p
YIL082W 0.48 Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag
YFL052W 0.48 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YJL116C 0.48
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YOL163W 0.47 Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family
YER179W 0.47
DMC1
Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein
YOR381W 0.47
FRE3
Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
YIL083C 0.46 Putative phosphopantothenoylcysteine synthetase (PPCS) that catalyzes the second step in the biosynthesis of coenzyme A from pantothenate; conserved in bacteria, humans, and plants; essential for viability
YER147C 0.46
SCC4
Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX
YOR100C 0.46
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YAL054C 0.46
ACS1
Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YDR298C 0.46
ATP5
Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
YPL078C 0.46
ATP4
Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YKR015C 0.46 Putative protein of unknown function
YLR281C 0.46 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene
YCR005C 0.46
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YBL082C 0.46
ALG3
Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins
YGR149W 0.46 Putative protein of unknown function; predicted to be an integal membrane protein
YPL200W 0.46
CSM4
Protein required for accurate chromosome segregation during meiosis
YHR096C 0.45
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YDL072C 0.45
YET3
Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein
YCL021W-A 0.45 Putative protein of unknown function
YOR071C 0.45
NRT1
High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
YLL020C 0.44 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KNS1
YEL049W 0.44
PAU2
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YPL223C 0.44
GRE1
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YLR337C 0.44
VRP1
Proline-rich actin-associated protein involved in cytoskeletal organization and cytokinesis; related to mammalian Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP)
YLR297W 0.44 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YLR297W is not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation
YGL045W 0.44
RIM8
Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF
YDL128W 0.43
VCX1
Vacuolar H+/Ca2+ exchanger involved in control of cytosolic Ca2+ concentration; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter
YGR045C 0.43 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAL017W 0.43
PSK1
One of two (see also PSK2) PAS domain containing S/T protein kinases; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status
YFR029W 0.43
PTR3
Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
YGR260W 0.43
TNA1
High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)
YOL126C 0.43
MDH2
Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1
YER033C 0.43
ZRG8
Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency
YGR137W 0.43 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR094C 0.42
GIS3
Protein of unknown function
YPL031C 0.42
PHO85
Cyclin-dependent kinase, with ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle
YPR024W 0.42
YME1
Subunit, with Mgr1p, of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; mutation causes an elevated rate of mitochondrial turnover
YLR121C 0.42
YPS3
Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YPL147W 0.42
PXA1
Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins
YJL089W 0.41
SIP4
C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus
YOR072W 0.41 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YKR016W 0.41
AIM28
Protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss and severe growth defect in minimal glycerol media
YCL001W-B 0.40 Putative protein of unknown function; identified by homology
YDL140C 0.40
RPO21
RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
YER004W 0.40
FMP52
Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation
YGR088W 0.40
CTT1
Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YBR183W 0.40
YPC1
Alkaline ceramidase that also has reverse (CoA-independent) ceramide synthase activity, catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance
YDR204W 0.39
COQ4
Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
YKR052C 0.39
MRS4
Mitochondrial iron transporter of the mitochondrial carrier family (MCF), very similar to and functionally redundant with Mrs3p; functions under low-iron conditions; may transport other cations in addition to iron
YML089C 0.39 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YOL001W 0.39
PHO80
Cyclin, negatively regulates phosphate metabolism; Pho80p-Pho85p (cyclin-CDK complex) phosphorylates Pho4p and Swi5p; deletion of PHO80 leads to aminoglycoside supersensitivity; truncated form of PHO80 affects vacuole inheritance
YHR092C 0.39
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YAR050W 0.39
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YIL037C 0.39
PRM2
Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p
YOR192C 0.39
THI72
Transporter of thiamine or related compound; shares sequence similarity with Thi7p
YDR452W 0.39
PPN1
Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer
YMR170C 0.38
ALD2
Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p
YDR505C 0.38
PSP1
Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition
YHR143W 0.38
DSE2
Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP
YJL152W 0.38 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR382W 0.38
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YML081C-A 0.38
ATP18
Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms
YMR306C-A 0.38 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR479C 0.38
PEX29
Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p
YHR086W 0.38
NAM8
RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of MER2 pre-mRNA
YOL143C 0.37
RIB4
Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin
YML042W 0.37
CAT2
Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes

Network of associatons between targets according to the STRING database.

First level regulatory network of RDS2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.5 1.6 GO:0010133 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
0.5 1.4 GO:0019541 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
0.5 2.3 GO:0015793 glycerol transport(GO:0015793)
0.4 1.3 GO:0015888 thiamine transport(GO:0015888)
0.4 1.2 GO:1905038 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.4 1.6 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.4 3.2 GO:0015891 siderophore transport(GO:0015891)
0.4 1.1 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
0.4 1.1 GO:0015755 fructose transport(GO:0015755)
0.3 1.6 GO:0072523 purine-containing compound catabolic process(GO:0072523)
0.3 2.8 GO:0006097 glyoxylate cycle(GO:0006097)
0.3 1.5 GO:0044070 regulation of anion transport(GO:0044070)
0.3 1.8 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.3 0.9 GO:0006108 malate metabolic process(GO:0006108)
0.3 0.9 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.3 0.8 GO:0033559 unsaturated fatty acid biosynthetic process(GO:0006636) unsaturated fatty acid metabolic process(GO:0033559)
0.3 0.8 GO:0009062 fatty acid catabolic process(GO:0009062)
0.2 0.9 GO:0006848 pyruvate transport(GO:0006848)
0.2 3.0 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.2 1.1 GO:0070941 eisosome assembly(GO:0070941)
0.2 0.4 GO:0035947 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
0.2 0.6 GO:0017006 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.2 0.6 GO:0010466 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
0.2 2.0 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.2 1.0 GO:0005980 glycogen catabolic process(GO:0005980)
0.2 4.0 GO:0015749 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.2 0.9 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.2 0.7 GO:0070199 establishment of protein localization to chromosome(GO:0070199) establishment of protein localization to chromatin(GO:0071169)
0.2 0.7 GO:0036498 mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response(GO:0030969) IRE1-mediated unfolded protein response(GO:0036498) mRNA splicing, via endonucleolytic cleavage and ligation(GO:0070054)
0.2 0.9 GO:0032075 positive regulation of nuclease activity(GO:0032075)
0.2 0.9 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.2 0.5 GO:0006553 lysine metabolic process(GO:0006553)
0.2 0.5 GO:0051469 vesicle fusion with vacuole(GO:0051469)
0.2 0.5 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.2 0.7 GO:0015976 carbon utilization(GO:0015976)
0.2 0.5 GO:0019748 secondary metabolic process(GO:0019748)
0.2 0.6 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.2 0.6 GO:0009300 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.2 0.6 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.2 1.4 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.1 0.7 GO:0034354 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.1 0.4 GO:0043200 response to amino acid(GO:0043200)
0.1 0.4 GO:0030149 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.1 0.5 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
0.1 1.7 GO:0045144 meiosis II(GO:0007135) meiotic sister chromatid segregation(GO:0045144)
0.1 0.4 GO:0048024 regulation of RNA splicing(GO:0043484) regulation of mRNA splicing, via spliceosome(GO:0048024) positive regulation of mRNA processing(GO:0050685)
0.1 1.6 GO:0006826 iron ion transport(GO:0006826)
0.1 1.5 GO:0019395 fatty acid oxidation(GO:0019395) lipid oxidation(GO:0034440)
0.1 0.4 GO:0046160 heme a biosynthetic process(GO:0006784) heme a metabolic process(GO:0046160)
0.1 0.7 GO:0072337 modified amino acid transport(GO:0072337)
0.1 0.6 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.1 0.4 GO:0071454 response to anoxia(GO:0034059) cellular response to anoxia(GO:0071454)
0.1 0.3 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.1 0.2 GO:0071545 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
0.1 0.8 GO:0006083 acetate metabolic process(GO:0006083)
0.1 0.2 GO:0000101 sulfur amino acid transport(GO:0000101)
0.1 0.3 GO:0019243 methylglyoxal metabolic process(GO:0009438) methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.1 0.5 GO:0000709 meiotic joint molecule formation(GO:0000709)
0.1 0.5 GO:0090220 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.1 0.3 GO:0006798 polyphosphate catabolic process(GO:0006798)
0.1 0.8 GO:0055071 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.1 0.5 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.1 0.5 GO:0046464 triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)
0.1 2.7 GO:0006094 gluconeogenesis(GO:0006094)
0.1 0.1 GO:0006074 (1->3)-beta-D-glucan metabolic process(GO:0006074)
0.1 0.5 GO:0042732 D-xylose metabolic process(GO:0042732)
0.1 1.4 GO:0006757 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.1 0.4 GO:0032102 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.1 0.2 GO:0045980 negative regulation of nucleotide metabolic process(GO:0045980)
0.1 0.7 GO:0015851 nucleobase transport(GO:0015851)
0.1 0.4 GO:0006598 polyamine catabolic process(GO:0006598)
0.1 0.9 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.1 0.5 GO:0009102 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.1 0.4 GO:0006828 manganese ion transport(GO:0006828)
0.1 0.1 GO:1900090 regulation of carbohydrate metabolic process by transcription from RNA polymerase II promoter(GO:0100024) regulation of inositol biosynthetic process(GO:1900088) positive regulation of inositol biosynthetic process(GO:1900090) regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter(GO:1900402)
0.1 0.2 GO:0036095 positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter(GO:0036095) positive regulation of invasive growth in response to glucose limitation(GO:2000219)
0.1 0.3 GO:0006829 zinc II ion transport(GO:0006829)
0.1 0.2 GO:0019935 cAMP-mediated signaling(GO:0019933) cyclic-nucleotide-mediated signaling(GO:0019935)
0.1 0.9 GO:0043409 negative regulation of MAPK cascade(GO:0043409)
0.1 0.2 GO:0000736 double-strand break repair via single-strand annealing, removal of nonhomologous ends(GO:0000736)
0.1 0.7 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.1 0.2 GO:0051101 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
0.1 0.2 GO:0043269 regulation of ion transport(GO:0043269)
0.1 0.4 GO:0046931 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.1 0.2 GO:0006883 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.1 0.2 GO:0009187 cyclic nucleotide metabolic process(GO:0009187)
0.1 0.5 GO:0045332 phospholipid translocation(GO:0045332)
0.1 0.3 GO:0019627 urea metabolic process(GO:0019627)
0.1 0.1 GO:0006531 aspartate metabolic process(GO:0006531)
0.1 0.9 GO:0001101 response to acid chemical(GO:0001101)
0.1 2.5 GO:0070726 cell wall assembly(GO:0070726)
0.1 0.3 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.1 0.3 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 5.1 GO:0045229 external encapsulating structure organization(GO:0045229) cell wall organization(GO:0071555)
0.1 0.3 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.1 0.1 GO:0008216 spermidine metabolic process(GO:0008216)
0.1 0.3 GO:0008053 mitochondrial fusion(GO:0008053)
0.1 0.2 GO:0051654 establishment of mitochondrion localization(GO:0051654)
0.1 0.7 GO:0006101 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101)
0.1 0.4 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.1 0.3 GO:0006465 signal peptide processing(GO:0006465)
0.1 0.1 GO:1904951 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
0.1 0.1 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.1 0.1 GO:0031138 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.0 0.6 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.0 0.1 GO:0006343 establishment of chromatin silencing(GO:0006343)
0.0 0.1 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
0.0 0.1 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.0 0.2 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.3 GO:0006771 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.0 0.2 GO:0042537 benzene-containing compound metabolic process(GO:0042537)
0.0 0.1 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.0 0.4 GO:0006882 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.0 0.2 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.3 GO:0018065 protein-cofactor linkage(GO:0018065)
0.0 0.1 GO:1900101 regulation of endoplasmic reticulum unfolded protein response(GO:1900101)
0.0 0.5 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.0 1.4 GO:0009060 aerobic respiration(GO:0009060)
0.0 0.1 GO:0031055 chromatin remodeling at centromere(GO:0031055)
0.0 0.2 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.2 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.3 GO:0006801 superoxide metabolic process(GO:0006801)
0.0 0.0 GO:0061416 regulation of transcription from RNA polymerase II promoter in response to salt stress(GO:0061416)
0.0 0.2 GO:1902532 negative regulation of intracellular signal transduction(GO:1902532)
0.0 0.4 GO:0015893 drug transport(GO:0015893)
0.0 0.2 GO:0022610 cell adhesion(GO:0007155) biological adhesion(GO:0022610)
0.0 0.1 GO:0000272 polysaccharide catabolic process(GO:0000272)
0.0 0.1 GO:0009450 gamma-aminobutyric acid metabolic process(GO:0009448) gamma-aminobutyric acid catabolic process(GO:0009450)
0.0 0.6 GO:1901700 response to oxygen-containing compound(GO:1901700)
0.0 0.1 GO:0043605 cellular amide catabolic process(GO:0043605)
0.0 0.4 GO:0051181 cofactor transport(GO:0051181)
0.0 0.4 GO:0019740 nitrogen utilization(GO:0019740)
0.0 0.2 GO:0046020 negative regulation of transcription by pheromones(GO:0045996) negative regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046020)
0.0 0.2 GO:0061188 negative regulation of chromatin silencing at rDNA(GO:0061188)
0.0 0.1 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.0 0.1 GO:0043255 regulation of carbohydrate biosynthetic process(GO:0043255)
0.0 0.2 GO:0000103 sulfate assimilation(GO:0000103)
0.0 0.3 GO:0044242 cellular lipid catabolic process(GO:0044242)
0.0 0.1 GO:0034762 regulation of transmembrane transport(GO:0034762)
0.0 0.1 GO:0018196 peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.4 GO:0000742 karyogamy involved in conjugation with cellular fusion(GO:0000742)
0.0 0.3 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.0 0.1 GO:0043112 receptor recycling(GO:0001881) protein import into peroxisome matrix, receptor recycling(GO:0016562) receptor metabolic process(GO:0043112)
0.0 0.2 GO:0016239 positive regulation of macroautophagy(GO:0016239) regulation of macroautophagy(GO:0016241)
0.0 0.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.1 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.0 0.1 GO:0009423 chorismate biosynthetic process(GO:0009423)
0.0 0.0 GO:0060962 regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060962)
0.0 0.1 GO:0042407 cristae formation(GO:0042407)
0.0 0.3 GO:0000147 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.0 0.3 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0 0.2 GO:0005985 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.0 0.2 GO:0016233 telomere capping(GO:0016233)
0.0 0.0 GO:0043966 histone H3 acetylation(GO:0043966) histone H3-K9 acetylation(GO:0043970) histone H3-K14 acetylation(GO:0044154) histone H3-K9 modification(GO:0061647)
0.0 0.1 GO:0042357 thiamine diphosphate biosynthetic process(GO:0009229) thiamine diphosphate metabolic process(GO:0042357) pyrimidine-containing compound catabolic process(GO:0072529)
0.0 0.1 GO:0001308 progressive alteration of chromatin involved in replicative cell aging(GO:0001304) negative regulation of chromatin silencing involved in replicative cell aging(GO:0001308)
0.0 0.0 GO:2001040 cellular response to drug(GO:0035690) regulation of response to drug(GO:2001023) positive regulation of response to drug(GO:2001025) regulation of cellular response to drug(GO:2001038) positive regulation of cellular response to drug(GO:2001040)
0.0 0.1 GO:0006743 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) ketone biosynthetic process(GO:0042181) quinone metabolic process(GO:1901661) quinone biosynthetic process(GO:1901663)
0.0 0.1 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.0 0.1 GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000448)
0.0 0.1 GO:0046513 ceramide metabolic process(GO:0006672) ceramide biosynthetic process(GO:0046513)
0.0 0.1 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.0 0.1 GO:0048209 regulation of COPII vesicle coating(GO:0003400) regulation of vesicle targeting, to, from or within Golgi(GO:0048209) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.0 0.1 GO:0006655 phosphatidylglycerol biosynthetic process(GO:0006655)
0.0 0.5 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.0 0.4 GO:0022900 electron transport chain(GO:0022900)
0.0 0.1 GO:0008214 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.0 0.4 GO:0098656 anion transmembrane transport(GO:0098656)
0.0 0.1 GO:0000821 regulation of glutamine family amino acid metabolic process(GO:0000820) regulation of arginine metabolic process(GO:0000821)
0.0 0.1 GO:0007121 bipolar cellular bud site selection(GO:0007121)
0.0 0.0 GO:0005993 trehalose catabolic process(GO:0005993)
0.0 0.1 GO:0031167 rRNA methylation(GO:0031167)
0.0 0.1 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 0.1 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.2 GO:0012501 apoptotic process(GO:0006915) cell death(GO:0008219) programmed cell death(GO:0012501)
0.0 0.1 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.0 GO:0045807 positive regulation of endocytosis(GO:0045807)
0.0 0.1 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.0 0.3 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.1 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143)
0.0 0.1 GO:0007532 regulation of mating-type specific transcription, DNA-templated(GO:0007532)
0.0 0.1 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.0 0.4 GO:0006839 mitochondrial transport(GO:0006839)
0.0 0.1 GO:0043007 maintenance of rDNA(GO:0043007)
0.0 0.3 GO:0032258 CVT pathway(GO:0032258)
0.0 0.1 GO:0015939 pantothenate metabolic process(GO:0015939) pantothenate biosynthetic process(GO:0015940)
0.0 0.0 GO:0006545 glycine biosynthetic process(GO:0006545) threonine catabolic process(GO:0006567)
0.0 0.0 GO:0031532 actin cytoskeleton reorganization(GO:0031532) lipid tube assembly(GO:0060988) protein-lipid complex assembly(GO:0065005) protein-lipid complex subunit organization(GO:0071825)
0.0 0.1 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.0 0.8 GO:0006457 protein folding(GO:0006457)
0.0 0.2 GO:0006895 Golgi to endosome transport(GO:0006895)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0046930 pore complex(GO:0046930)
0.3 0.9 GO:0000274 mitochondrial proton-transporting ATP synthase, stator stalk(GO:0000274) proton-transporting ATP synthase, stator stalk(GO:0045265)
0.2 1.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.2 0.6 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.2 0.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.2 8.8 GO:0031225 anchored component of membrane(GO:0031225)
0.2 0.5 GO:0045252 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.2 0.6 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.2 0.5 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.2 2.3 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.2 0.9 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.1 0.7 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1 0.4 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.1 0.6 GO:0032221 Rpd3S complex(GO:0032221)
0.1 0.5 GO:0032116 SMC loading complex(GO:0032116)
0.1 3.8 GO:0005576 extracellular region(GO:0005576)
0.1 0.3 GO:0030061 mitochondrial crista(GO:0030061)
0.1 0.7 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.1 0.4 GO:0008623 CHRAC(GO:0008623)
0.1 2.3 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 0.5 GO:0034657 GID complex(GO:0034657)
0.1 0.2 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.1 0.4 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 0.5 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 0.4 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.1 3.1 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 0.5 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.1 1.1 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.1 1.5 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 0.4 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.1 0.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 0.7 GO:0098552 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.0 1.4 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.2 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 0.4 GO:0005619 ascospore wall(GO:0005619)
0.0 3.0 GO:0010008 endosome membrane(GO:0010008)
0.0 0.8 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.1 GO:0032126 eisosome(GO:0032126)
0.0 0.1 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.0 0.3 GO:0033698 Rpd3L complex(GO:0033698)
0.0 0.2 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.2 GO:0009277 fungal-type cell wall(GO:0009277)
0.0 0.1 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.0 7.8 GO:0005886 plasma membrane(GO:0005886)
0.0 6.1 GO:0005740 mitochondrial envelope(GO:0005740)
0.0 0.5 GO:0005844 polysome(GO:0005844)
0.0 0.2 GO:0019866 organelle inner membrane(GO:0019866)
0.0 0.1 GO:0072380 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.0 0.2 GO:0000795 synaptonemal complex(GO:0000795)
0.0 2.6 GO:0044429 mitochondrial part(GO:0044429)
0.0 0.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.5 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 0.1 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.2 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0 0.1 GO:0097196 Shu complex(GO:0097196)
0.0 1.4 GO:0000324 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.0 0.3 GO:0005811 lipid particle(GO:0005811)
0.0 0.1 GO:0005869 dynactin complex(GO:0005869)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.9 GO:0015603 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.6 3.0 GO:0015295 solute:proton symporter activity(GO:0015295)
0.6 1.7 GO:0022829 porin activity(GO:0015288) wide pore channel activity(GO:0022829)
0.5 1.6 GO:0016208 AMP binding(GO:0016208)
0.5 2.1 GO:0004396 hexokinase activity(GO:0004396)
0.4 1.8 GO:0005537 mannose binding(GO:0005537)
0.4 0.8 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
0.4 2.6 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.4 1.1 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
0.4 1.1 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.3 2.7 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.3 0.9 GO:0016289 CoA hydrolase activity(GO:0016289)
0.3 0.6 GO:0016405 CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
0.2 1.0 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.2 2.5 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.2 0.2 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.2 0.9 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.2 3.0 GO:0005353 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.2 0.6 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.2 2.2 GO:0010181 FMN binding(GO:0010181)
0.2 2.0 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.2 0.6 GO:0030414 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
0.2 1.0 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.2 1.0 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.2 1.6 GO:0005216 ion channel activity(GO:0005216)
0.2 1.7 GO:0000293 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.2 2.1 GO:0005199 structural constituent of cell wall(GO:0005199)
0.2 0.8 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.2 0.5 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
0.2 0.5 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.2 0.5 GO:0035591 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.2 0.8 GO:0034318 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.2 0.3 GO:0022838 substrate-specific channel activity(GO:0022838)
0.1 1.2 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 0.6 GO:0022821 potassium:proton antiporter activity(GO:0015386) potassium ion antiporter activity(GO:0022821)
0.1 1.6 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.1 1.3 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.1 0.5 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
0.1 0.5 GO:0016417 S-acyltransferase activity(GO:0016417)
0.1 0.9 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 1.3 GO:0038023 transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) transmembrane receptor activity(GO:0099600)
0.1 0.7 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.1 0.6 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.1 0.5 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 0.3 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.1 0.3 GO:0004575 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
0.1 0.7 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 1.4 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors(GO:0016645)
0.1 2.1 GO:0016836 hydro-lyase activity(GO:0016836)
0.1 1.3 GO:0020037 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.1 0.2 GO:0004872 receptor activity(GO:0004872) molecular transducer activity(GO:0060089)
0.1 1.5 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 0.7 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.1 0.3 GO:0019776 Atg8 ligase activity(GO:0019776)
0.1 0.3 GO:0008897 holo-[acyl-carrier-protein] synthase activity(GO:0008897)
0.1 0.6 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 0.2 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.1 0.4 GO:0004806 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.1 0.4 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.1 0.2 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
0.1 0.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 0.2 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.1 0.3 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.5 GO:0034979 NAD-dependent histone deacetylase activity(GO:0017136) NAD-dependent protein deacetylase activity(GO:0034979)
0.1 0.2 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.1 0.4 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.1 0.2 GO:0004180 carboxypeptidase activity(GO:0004180)
0.1 0.2 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.1 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.0 0.5 GO:0019239 deaminase activity(GO:0019239)
0.0 0.9 GO:0051087 chaperone binding(GO:0051087)
0.0 3.1 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.2 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
0.0 0.4 GO:0051184 cofactor transporter activity(GO:0051184)
0.0 0.1 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.7 GO:0050661 NADP binding(GO:0050661)
0.0 0.1 GO:0008137 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.2 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.0 0.8 GO:0008483 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.0 0.2 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.3 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 0.3 GO:0015293 symporter activity(GO:0015293)
0.0 0.2 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.3 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.1 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.0 0.2 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 0.2 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 0.1 GO:0019003 GDP binding(GO:0019003)
0.0 0.2 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 0.2 GO:0015923 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.0 1.8 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.5 GO:0046961 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.4 GO:0046527 glucosyltransferase activity(GO:0046527)
0.0 0.3 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 0.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.1 GO:0017171 serine hydrolase activity(GO:0017171)
0.0 0.2 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0 0.1 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.0 0.1 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.0 0.2 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0 0.8 GO:0061733 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.0 0.1 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0 0.8 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.0 0.1 GO:0004738 pyruvate dehydrogenase activity(GO:0004738)
0.0 0.1 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.1 GO:0008902 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.0 0.3 GO:0015238 drug transmembrane transporter activity(GO:0015238)
0.0 0.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0005471 purine ribonucleotide transmembrane transporter activity(GO:0005346) ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
0.0 0.1 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.0 0.1 GO:0005186 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.0 0.3 GO:0051015 actin filament binding(GO:0051015)
0.0 0.2 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.1 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.1 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.1 GO:0031072 heat shock protein binding(GO:0031072)
0.0 0.1 GO:0016830 carbon-carbon lyase activity(GO:0016830)
0.0 0.1 GO:0019238 cyclohydrolase activity(GO:0019238)
0.0 0.2 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.1 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.0 0.1 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 0.1 GO:0042054 histone methyltransferase activity(GO:0042054)
0.0 0.1 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.7 GO:0016758 transferase activity, transferring hexosyl groups(GO:0016758)
0.0 0.1 GO:0005496 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.0 0.1 GO:0004620 phospholipase activity(GO:0004620)
0.0 0.1 GO:0042124 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.0 0.1 GO:0016684 peroxidase activity(GO:0004601) oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 PID IL4 2PATHWAY IL4-mediated signaling events
0.5 1.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 1.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 0.4 PID PLK1 PATHWAY PLK1 signaling events
0.1 0.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.1 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.2 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.1 PID P73PATHWAY p73 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.2 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.2 0.5 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.2 0.7 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 0.6 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 0.3 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.1 0.2 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 0.2 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.1 0.5 REACTOME MEIOSIS Genes involved in Meiosis
0.0 0.6 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.2 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.2 REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.0 0.1 REACTOME HEMOSTASIS Genes involved in Hemostasis