Results for RDR1
Z-value: 0.80
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Transcription factors associated with RDR1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
RDR1
|
S000005907 | Transcriptional repressor involved in regulating multidrug resistance |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YDR345C Show fit | 3.97 |
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions |
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| YHR092C Show fit | 3.87 |
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose |
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| YGR108W Show fit | 3.86 |
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome |
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| YKL096W-A Show fit | 3.81 |
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored |
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| YJR105W Show fit | 2.68 |
Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle |
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| YGL055W Show fit | 2.67 |
Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria |
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| YCL064C Show fit | 2.64 |
Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine |
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| YLR328W Show fit | 2.45 |
Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways |
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| YFR055W Show fit | 2.29 |
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner |
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| YLR110C Show fit | 2.27 |
Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor |
Network of associatons between targets according to the STRING database.
First level regulatory network of RDR1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.2 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.2 | 4.6 | GO:0006096 | glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757) |
| 0.6 | 4.3 | GO:0010696 | positive regulation of spindle pole body separation(GO:0010696) |
| 0.2 | 4.0 | GO:0006885 | regulation of pH(GO:0006885) |
| 0.4 | 3.6 | GO:0000947 | amino acid catabolic process to alcohol via Ehrlich pathway(GO:0000947) |
| 0.0 | 3.4 | GO:0006364 | rRNA processing(GO:0006364) |
| 1.1 | 3.3 | GO:0006567 | threonine catabolic process(GO:0006567) |
| 0.3 | 3.1 | GO:0009435 | NAD biosynthetic process(GO:0009435) |
| 0.2 | 3.1 | GO:0019682 | pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682) |
| 0.1 | 3.1 | GO:0006633 | fatty acid biosynthetic process(GO:0006633) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.9 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.1 | 10.0 | GO:0005576 | extracellular region(GO:0005576) |
| 0.1 | 8.8 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 6.3 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.1 | 5.7 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 5.1 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 5.0 | GO:0005886 | plasma membrane(GO:0005886) |
| 0.3 | 4.5 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 3.6 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.8 | 2.4 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.4 | 4.8 | GO:0005199 | structural constituent of cell wall(GO:0005199) |
| 0.2 | 4.7 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.1 | 4.6 | GO:0003924 | GTPase activity(GO:0003924) |
| 1.1 | 4.3 | GO:0015146 | pentose transmembrane transporter activity(GO:0015146) |
| 0.9 | 3.7 | GO:0016841 | ammonia-lyase activity(GO:0016841) |
| 0.6 | 3.6 | GO:0004022 | alcohol dehydrogenase (NAD) activity(GO:0004022) |
| 0.2 | 3.4 | GO:0015926 | glucosidase activity(GO:0015926) |
| 0.3 | 2.8 | GO:0005216 | ion channel activity(GO:0005216) |
| 0.7 | 2.7 | GO:0019206 | nucleoside kinase activity(GO:0019206) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.3 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.2 | 0.6 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 0.2 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.1 | 0.1 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 0.1 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 0.1 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.0 | 0.1 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.0 | 0.1 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 0.0 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.0 | 0.0 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 2.6 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 2.0 | REACTOME METABOLISM OF MRNA | Genes involved in Metabolism of mRNA |
| 0.2 | 1.2 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 0.2 | 1.2 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.1 | 0.9 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.2 | 0.5 | REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION | Genes involved in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| 0.2 | 0.4 | REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |
| 0.1 | 0.3 | REACTOME SIGNALING BY INSULIN RECEPTOR | Genes involved in Signaling by Insulin receptor |
| 0.1 | 0.3 | REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION | Genes involved in Platelet activation, signaling and aggregation |
| 0.1 | 0.2 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |