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Results for RCS1

Z-value: 3.75

Activity profile of RCS1 motif

Sorted Z-values of RCS1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YOR382W 67.57
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YOR383C 58.99
FIT3
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YDR536W 49.64
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YKL217W 43.19
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YIL057C 41.84 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YDL210W 36.77
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YHR139C 36.75
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YLR327C 36.61
TMA10
Protein of unknown function that associates with ribosomes
YMR175W 32.97
SIP18
Protein of unknown function whose expression is induced by osmotic stress
YBL049W 29.53
MOH1
Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase
YAR053W 29.37 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHL040C 28.26
ARN1
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores
YMR017W 28.18
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YLR205C 27.05
HMX1
ER localized, heme-binding peroxidase involved in the degradation of heme; does not exhibit heme oxygenase activity despite similarity to heme oxygenases; expression regulated by AFT1
YOR100C 26.50
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YEL065W 25.89
SIT1
Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
YLR136C 25.29
TIS11
mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis
YGR087C 25.20
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YKL031W 25.05 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YOR381W 24.27
FRE3
Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
YFR053C 24.04
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YHR217C 22.34 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; located in the telomeric region TEL08R.
YFL063W 22.03 Dubious open reading frame, based on available experimental and comparative sequence data
YIL055C 21.83 Putative protein of unknown function
YAR060C 21.45 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL072C 21.14 Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YJL045W 20.79 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YMR244W 20.32 Putative protein of unknown function
YFL064C 20.22 Putative protein of unknown function
YMR056C 20.10
AAC1
Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator
YER084W 20.08 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPR151C 19.53
SUE1
Mitochondrial protein required for degradation of unstable forms of cytochrome c
YAL062W 19.45
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YGR032W 19.30
GSC2
Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
YER065C 18.88
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YDR269C 18.69 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER158C 18.05 Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p
YPL054W 17.62
LEE1
Zinc-finger protein of unknown function
YDR270W 17.60
CCC2
Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases
YGL146C 17.08 Putative protein of unknown function, contains two putative transmembrane spans, shows no significant homology to any other known protein sequence, YGL146C is not an essential gene
YHR212C 16.54 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YAL034C 16.09
FUN19
Non-essential protein of unknown function
YGR256W 15.97
GND2
6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone
YPL017C 15.50
IRC15
Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family, required for accurate meiotic chromosome segregation; null mutant displays increased levels of spontaneous Rad52 foci
YPL250C 15.40
ICY2
Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YHR212W-A 15.38 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YJR155W 15.37
AAD10
Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role
YCR005C 15.18
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YHL046W-A 15.11 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YEL060C 14.87
PRB1
Vacuolar proteinase B (yscB), a serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation
YCR025C 14.67 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene
YFL051C 14.62 Putative protein of unknown function; YFL051C is not an essential gene
YOL084W 14.44
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YER014C-A 14.40
BUD25
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YOR152C 14.36 Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YFL052W 14.29 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YHR218W 14.22 Helicase-like protein encoded within the telomeric Y' element
YHL047C 14.01
ARN2
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C
YGR088W 13.89
CTT1
Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YDR043C 13.83
NRG1
Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YMR107W 13.64
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YMR174C 13.46
PAI3
Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact
YFL062W 13.20
COS4
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YGR258C 12.94
RAD2
Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
YBR292C 12.89 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
YGL071W 12.78
AFT1
Transcription factor involved in iron utilization and homeostasis; binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability
YMR206W 12.69 Putative protein of unknown function; YMR206W is not an essential gene
YDL067C 12.62
COX9
Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YOR120W 12.53
GCY1
Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family
YOR384W 12.26
FRE5
Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YEL070W 11.98
DSF1
Deletion suppressor of mpt5 mutation
YOR346W 11.54
REV1
Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YLR356W 11.54 Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YIL146C 11.40
ECM37
Non-essential protein of unknown function
YPR192W 11.38
AQY1
Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance
YMR194C-B 11.38 Putative protein of unknown function
YLR004C 11.37
THI73
Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
YLL029W 11.34
FRA1
Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation
YMR081C 11.08
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YOR227W 10.98 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR345C 10.98 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YOL082W 10.96
ATG19
Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; recognizes cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) and delivers them to the preautophagosomal structure for packaging into Cvt vesicles
YOR235W 10.94
IRC13
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci
YDR178W 10.91
SDH4
Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YAL018C 10.87 Putative protein of unknown function
YOR178C 10.68
GAC1
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YBR072W 10.54
HSP26
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YLR030W 10.47 Putative protein of unknown function
YCR021C 10.46
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YPR013C 10.30 Putative zinc finger protein; YPR013C is not an essential gene
YDR343C 10.19
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YLR047C 10.18
FRE8
Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p
YLR334C 10.04 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here
YBR203W 10.02
COS111
Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKL028W 10.01
TFA1
TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening
YMR271C 9.97
URA10
Minor orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; major OPRTase encoded by URA5
YHR139C-A 9.92 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR186C 9.90 Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YMR034C 9.86 Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene
YKL044W 9.76 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL237W 9.76
YTP1
Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins
YOR072W 9.71 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YPR184W 9.55
GDB1
Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria
YPL024W 9.48
RMI1
Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YOR121C 9.34 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W
YOR328W 9.24
PDR10
ATP-binding cassette (ABC) transporter, multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p
YMR256C 9.20
COX7
Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YPL271W 9.18
ATP15
Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YBR047W 9.06
FMP23
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YMR181C 9.03 Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); YMR181C is not an essential gene
YLL053C 9.03 Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YOL118C 8.96 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YFR029W 8.80
PTR3
Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
YJL089W 8.76
SIP4
C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus
YKR103W 8.75
NFT1
Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds.
YKL032C 8.71
IXR1
Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b
YHR145C 8.65 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR231C 8.64
COX20
Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
YPL026C 8.63
SKS1
Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YJL133C-A 8.46 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR043C 8.35
NQM1
Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity
YKL046C 8.34
DCW1
Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p
YGR065C 8.32
VHT1
High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
YDL199C 8.27 Putative transporter, member of the sugar porter family
YDR171W 8.25
HSP42
Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock
YER020W 8.25
GPA2
Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YLR267W 8.24
BOP2
Protein of unknown function, overproduction suppresses a pam1 slv3 double null mutation
YFR017C 8.18 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene
YPR065W 8.16
ROX1
Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity
YDL130W-A 8.16
STF1
Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein
YPR078C 8.12 Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible
YPR026W 8.11
ATH1
Acid trehalase required for utilization of extracellular trehalose
YOR071C 8.10
NRT1
High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
YLL052C 8.09
AQY2
Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YKL192C 8.07
ACP1
Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p
YDL182W 8.02
LYS20
Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys21p
YBR132C 7.93
AGP2
High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease
YML133C 7.92 Putative protein of unknown function with similarity to helicases; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YML133C contains an intron
YOR072W-A 7.88 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR072W; originally identified by fungal homology and RT-PCR
YDR406W 7.88
PDR15
Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
YHR176W 7.84
FMO1
Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins
YNL144C 7.76 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YGR243W 7.73
FMP43
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBR077C 7.69
SLM4
Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
YLL019C 7.64
KNS1
Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues
YBR046C 7.58
ZTA1
Zeta-crystallin homolog, found in the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin, which has quinone oxidoreductase activity
YBR117C 7.56
TKL2
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YHL035C 7.53
VMR1
Protein of unknown function that may interact with ribosomes, based on co-purification experiments; member of the ATP-binding cassette (ABC) family; potential Cdc28p substrate; detected in purified mitochondria in high-throughput studies
YDL218W 7.45 Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions
YOL085W-A 7.42 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YOL085C
YER145C 7.42
FTR1
High affinity iron permease involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron
YKL163W 7.40
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YER101C 7.39
AST2
Protein that may have a role in targeting of plasma membrane [H+]ATPase (Pma1p) to the plasma membrane, as suggested by analysis of genetic interactions
YOR186W 7.34 Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent
YJR046W 7.30
TAH11
DNA replication licensing factor, required for pre-replication complex assembly
YMR057C 7.25 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1
YMR135C 7.24
GID8
Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START
YHR048W 7.23
YHK8
Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
YFL019C 7.14 Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene
YDR258C 7.12
HSP78
Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; prevents the aggregation of misfolded matrix proteins; component of the mitochondrial proteolysis system
YIL162W 7.11
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YMR195W 7.06
ICY1
Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
YOL035C 7.05 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL161W 7.01
FMP33
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJR045C 7.01
SSC1
Mitochondrial matrix ATPase, subunit of the presequence translocase-associated protein import motor (PAM) and of SceI endonuclease; involved in protein folding and translocation into the matrix; phosphorylated; member of HSP70 family
YNL339C 7.00
YRF1-6
Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p
YHR096C 6.96
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YER067W 6.95 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YER067W is not an essential gene
YPL156C 6.91
PRM4
Pheromone-regulated protein, predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift
YPL057C 6.88
SUR1
Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p
YAL061W 6.81
BDH2
Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; BDH2 is an essential gene
YCL001W-A 6.80 Putative protein of unknown function; YCL001W-A is not an essential gene
YDL196W 6.71 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31
YGL258W-A 6.68 Putative protein of unknown function
YMR103C 6.66 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL043W 6.63
PHD1
Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate
YKR067W 6.61
GPT2
Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis
YOR387C 6.59 Putative protein of unknown function; regulated by the metal-responsive Aft1p transcription factor; highly inducible in zinc-depleted conditions; localizes to the soluble fraction
YBR241C 6.57 Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene
YCL025C 6.55
AGP1
Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)
YGL096W 6.53
TOS8
Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p
YEL074W 6.51 Hypothetical protein
YOL083W 6.50 Hypothetical protein
YEL030C-A 6.49 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YOL047C 6.47 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YKR102W 6.40
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YKL103C 6.36
LAP4
Vacuolar aminopeptidase, often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway
YNR034W-A 6.35 Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YFL021W 6.32
GAT1
Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p
YKL038W 6.30
RGT1
Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor
YLL051C 6.30
FRE6
Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels
YPL111W 6.30
CAR1
Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance
YDL204W 6.25
RTN2
Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily
YBL015W 6.24
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YNL283C 6.19
WSC2
Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response
YOR388C 6.15
FDH1
NAD(+)-dependent formate dehydrogenase, may protect cells from exogenous formate
YPL135W 6.10
ISU1
Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable
YER150W 6.03
SPI1
GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YDL197C 5.99
ASF2
Anti-silencing protein that causes derepression of silent loci when overexpressed
YPL061W 5.99
ALD6
Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress

Network of associatons between targets according to the STRING database.

First level regulatory network of RCS1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
27.1 216.5 GO:0015891 siderophore transport(GO:0015891)
13.1 52.4 GO:0006848 pyruvate transport(GO:0006848)
9.9 49.6 GO:0015793 glycerol transport(GO:0015793)
7.9 31.7 GO:0015847 putrescine transport(GO:0015847)
7.8 23.5 GO:0010466 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
7.5 30.1 GO:0071462 response to water(GO:0009415) cellular response to water stimulus(GO:0071462)
7.4 22.2 GO:0015755 fructose transport(GO:0015755)
6.6 26.3 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
6.2 18.6 GO:0032780 negative regulation of ATPase activity(GO:0032780)
6.0 18.0 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
5.8 23.2 GO:0015886 heme transport(GO:0015886)
5.8 17.3 GO:0019676 ammonia assimilation cycle(GO:0019676)
5.7 17.1 GO:0043335 protein unfolding(GO:0043335)
5.4 21.5 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
4.7 9.5 GO:0061414 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
4.6 13.8 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
4.6 41.0 GO:0006097 glyoxylate cycle(GO:0006097)
4.6 13.7 GO:0042843 D-xylose catabolic process(GO:0042843)
4.4 13.1 GO:0034395 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
4.3 12.9 GO:0015888 thiamine transport(GO:0015888)
4.2 12.7 GO:0043270 positive regulation of ion transport(GO:0043270)
4.0 12.0 GO:0006827 high-affinity iron ion transmembrane transport(GO:0006827)
4.0 4.0 GO:0046487 glyoxylate metabolic process(GO:0046487)
3.9 19.7 GO:0035434 copper ion transmembrane transport(GO:0035434)
3.5 10.6 GO:0006108 malate metabolic process(GO:0006108)
3.5 3.5 GO:1901678 iron coordination entity transport(GO:1901678)
3.4 10.2 GO:0072488 ammonium transmembrane transport(GO:0072488)
3.3 9.8 GO:0006883 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
3.3 16.3 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
3.2 12.9 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
3.2 12.7 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
3.2 6.3 GO:0046323 glucose import(GO:0046323)
3.0 6.0 GO:0006740 NADPH regeneration(GO:0006740)
2.9 11.7 GO:0051101 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
2.8 16.7 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
2.7 13.7 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
2.7 8.2 GO:0009106 lipoate metabolic process(GO:0009106) lipoate biosynthetic process(GO:0009107)
2.7 8.1 GO:0005993 trehalose catabolic process(GO:0005993)
2.7 24.1 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
2.6 2.6 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
2.6 7.8 GO:0015691 cadmium ion transport(GO:0015691)
2.6 15.4 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
2.5 7.4 GO:0019627 urea metabolic process(GO:0019627)
2.4 7.3 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
2.4 19.0 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
2.3 11.5 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
2.3 4.5 GO:0051352 negative regulation of protein ubiquitination(GO:0031397) negative regulation of ligase activity(GO:0051352) negative regulation of ubiquitin-protein transferase activity(GO:0051444) negative regulation of protein modification by small protein conjugation or removal(GO:1903321)
2.2 8.7 GO:0043200 response to amino acid(GO:0043200)
2.2 8.6 GO:0071456 cellular response to hypoxia(GO:0071456)
2.1 6.4 GO:0006545 glycine biosynthetic process(GO:0006545)
2.1 21.2 GO:0009743 response to carbohydrate(GO:0009743)
2.1 10.5 GO:0090294 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
2.1 10.5 GO:0005980 glycogen catabolic process(GO:0005980)
2.1 6.3 GO:0032371 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
2.1 6.3 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
2.0 8.1 GO:0000256 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256) cellular amide catabolic process(GO:0043605)
1.8 18.4 GO:0015893 drug transport(GO:0015893)
1.8 1.8 GO:0001315 age-dependent response to reactive oxygen species(GO:0001315) cellular age-dependent response to reactive oxygen species(GO:0072353)
1.8 1.8 GO:0042743 hydrogen peroxide metabolic process(GO:0042743)
1.7 26.2 GO:0031321 ascospore-type prospore assembly(GO:0031321)
1.7 3.5 GO:0019748 secondary metabolic process(GO:0019748)
1.7 17.4 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
1.7 5.2 GO:0006577 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
1.7 8.6 GO:0051180 vitamin transport(GO:0051180)
1.7 10.0 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
1.6 4.9 GO:0045117 azole transport(GO:0045117)
1.6 1.6 GO:0006824 cobalt ion transport(GO:0006824)
1.6 11.1 GO:0008615 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
1.6 6.3 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
1.6 9.4 GO:0046352 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987) disaccharide catabolic process(GO:0046352)
1.5 14.9 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
1.5 5.9 GO:0006598 polyamine catabolic process(GO:0006598)
1.5 11.8 GO:0006829 zinc II ion transport(GO:0006829)
1.4 20.2 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
1.4 17.2 GO:0005978 glycogen biosynthetic process(GO:0005978)
1.4 18.4 GO:0045144 meiosis II(GO:0007135) meiotic sister chromatid segregation(GO:0045144)
1.4 1.4 GO:0006687 glycosphingolipid metabolic process(GO:0006687)
1.4 6.9 GO:0015677 copper ion import(GO:0015677)
1.4 4.1 GO:0046688 response to copper ion(GO:0046688)
1.3 6.6 GO:0043954 cellular component maintenance(GO:0043954)
1.3 5.2 GO:0030026 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
1.3 3.8 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
1.3 6.4 GO:0006083 acetate metabolic process(GO:0006083)
1.3 8.8 GO:0000023 maltose metabolic process(GO:0000023)
1.3 16.4 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
1.3 3.8 GO:0061393 positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress(GO:0061393)
1.3 11.3 GO:0070987 error-free translesion synthesis(GO:0070987)
1.2 1.2 GO:0009313 oligosaccharide catabolic process(GO:0009313)
1.2 3.6 GO:0010942 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
1.2 3.6 GO:0050685 positive regulation of mRNA processing(GO:0050685)
1.2 2.4 GO:0036095 positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter(GO:0036095) positive regulation of invasive growth in response to glucose limitation(GO:2000219)
1.2 4.7 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
1.1 29.8 GO:0055072 iron ion homeostasis(GO:0055072)
1.1 3.3 GO:0007232 osmosensory signaling pathway via Sho1 osmosensor(GO:0007232)
1.1 14.3 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
1.1 4.3 GO:0031138 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
1.1 9.5 GO:0006119 oxidative phosphorylation(GO:0006119)
1.0 3.1 GO:0071545 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
1.0 1.0 GO:0001666 response to hypoxia(GO:0001666)
1.0 3.0 GO:0045981 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
1.0 3.0 GO:0052652 cAMP biosynthetic process(GO:0006171) cyclic nucleotide biosynthetic process(GO:0009190) cyclic purine nucleotide metabolic process(GO:0052652)
1.0 7.9 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
1.0 4.9 GO:0032048 cardiolipin metabolic process(GO:0032048)
1.0 23.6 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
1.0 38.4 GO:0070591 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
1.0 11.7 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
1.0 6.7 GO:0018345 protein palmitoylation(GO:0018345)
0.9 5.6 GO:0006537 glutamate biosynthetic process(GO:0006537)
0.9 2.8 GO:0019541 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
0.9 2.8 GO:0031507 heterochromatin assembly(GO:0031507)
0.9 8.2 GO:0031167 rRNA methylation(GO:0031167)
0.9 3.7 GO:0001308 negative regulation of chromatin silencing involved in replicative cell aging(GO:0001308)
0.9 3.7 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.9 0.9 GO:0051099 positive regulation of binding(GO:0051099)
0.9 1.8 GO:0006754 ATP biosynthetic process(GO:0006754)
0.9 1.8 GO:0045596 negative regulation of cell differentiation(GO:0045596)
0.9 4.4 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.9 14.7 GO:0022900 electron transport chain(GO:0022900)
0.9 1.7 GO:0008272 sulfate transport(GO:0008272)
0.8 7.2 GO:0015802 basic amino acid transport(GO:0015802)
0.8 3.2 GO:0015804 neutral amino acid transport(GO:0015804)
0.8 4.0 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.8 6.2 GO:0046686 response to cadmium ion(GO:0046686)
0.8 3.8 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.8 7.7 GO:0042724 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.8 0.8 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.8 3.8 GO:0034486 amino acid export(GO:0032973) amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.8 2.3 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.8 2.3 GO:0018063 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.7 3.0 GO:1903513 retrograde protein transport, ER to cytosol(GO:0030970) endoplasmic reticulum to cytosol transport(GO:1903513)
0.7 2.1 GO:0090295 nitrogen catabolite repression of transcription(GO:0090295)
0.7 2.1 GO:0071050 snoRNA polyadenylation(GO:0071050)
0.7 11.8 GO:0098656 anion transmembrane transport(GO:0098656)
0.7 1.3 GO:0090153 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.7 3.3 GO:0034627 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.7 9.2 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.7 8.6 GO:0042026 protein refolding(GO:0042026)
0.7 10.5 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.6 3.8 GO:0006882 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.6 4.4 GO:0030242 pexophagy(GO:0030242)
0.6 1.2 GO:0010446 response to alkaline pH(GO:0010446) cellular response to alkaline pH(GO:0071469)
0.6 1.9 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037) actin filament reorganization(GO:0090527)
0.6 0.6 GO:0051098 regulation of binding(GO:0051098)
0.6 1.2 GO:0010455 positive regulation of cell fate commitment(GO:0010455) positive regulation of mating type switching(GO:0031496) positive regulation of cell differentiation(GO:0045597)
0.6 1.8 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.6 3.5 GO:0006816 calcium ion transport(GO:0006816)
0.6 14.2 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.6 1.7 GO:0036257 multivesicular body organization(GO:0036257)
0.6 1.1 GO:0051058 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.6 1.7 GO:0034762 regulation of transmembrane transport(GO:0034762)
0.5 1.1 GO:0006527 arginine catabolic process(GO:0006527)
0.5 3.3 GO:0019722 calcium-mediated signaling(GO:0019722)
0.5 1.6 GO:0019388 galactose catabolic process(GO:0019388)
0.5 2.1 GO:0070988 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.5 1.6 GO:0071041 antisense RNA transcript catabolic process(GO:0071041)
0.5 6.8 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.5 3.1 GO:0000338 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.5 4.2 GO:0051181 cofactor transport(GO:0051181)
0.5 5.5 GO:0006749 glutathione metabolic process(GO:0006749)
0.5 9.9 GO:0032258 CVT pathway(GO:0032258)
0.5 15.3 GO:0000282 cellular bud site selection(GO:0000282) mitotic cytokinesis, site selection(GO:1902408)
0.5 5.7 GO:0001101 response to acid chemical(GO:0001101)
0.5 18.4 GO:0009060 aerobic respiration(GO:0009060)
0.5 0.9 GO:0045895 positive regulation of mating-type specific transcription, DNA-templated(GO:0045895)
0.5 3.6 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.4 9.4 GO:0016579 protein deubiquitination(GO:0016579)
0.4 4.0 GO:0045332 phospholipid translocation(GO:0045332)
0.4 1.3 GO:0015740 C4-dicarboxylate transport(GO:0015740)
0.4 1.3 GO:0000272 polysaccharide catabolic process(GO:0000272)
0.4 0.8 GO:0032006 regulation of TOR signaling(GO:0032006)
0.4 1.2 GO:0001927 exocyst assembly(GO:0001927)
0.4 3.7 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.4 4.1 GO:0006865 amino acid transport(GO:0006865)
0.4 1.2 GO:0032102 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.4 0.8 GO:0006798 polyphosphate catabolic process(GO:0006798)
0.4 6.0 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.4 2.0 GO:0009410 response to xenobiotic stimulus(GO:0009410)
0.4 1.2 GO:1903339 inactivation of MAPK activity involved in cell wall organization or biogenesis(GO:0000200) regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903137) negative regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903138) negative regulation of cell wall organization or biogenesis(GO:1903339)
0.4 0.8 GO:0006311 meiotic gene conversion(GO:0006311)
0.4 1.5 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143)
0.4 0.4 GO:0070417 unsaturated fatty acid biosynthetic process(GO:0006636) response to cold(GO:0009409) unsaturated fatty acid metabolic process(GO:0033559) cellular response to cold(GO:0070417)
0.4 0.4 GO:0007571 age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline involved in chronological cell aging(GO:0001323) age-dependent response to oxidative stress involved in chronological cell aging(GO:0001324) age-dependent general metabolic decline(GO:0007571)
0.4 3.0 GO:0044088 regulation of vacuole fusion, non-autophagic(GO:0032889) regulation of vacuole organization(GO:0044088)
0.4 2.3 GO:0000266 mitochondrial fission(GO:0000266)
0.4 7.1 GO:0007266 Rho protein signal transduction(GO:0007266)
0.4 0.4 GO:0007032 endosome organization(GO:0007032)
0.4 2.6 GO:0046916 cellular transition metal ion homeostasis(GO:0046916)
0.4 0.7 GO:0000019 regulation of mitotic recombination(GO:0000019)
0.4 1.5 GO:0031134 sister chromatid biorientation(GO:0031134)
0.3 1.4 GO:0015976 carbon utilization(GO:0015976)
0.3 2.0 GO:0009231 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.3 1.0 GO:0060237 regulation of fungal-type cell wall organization(GO:0060237)
0.3 1.0 GO:0044783 G1 DNA damage checkpoint(GO:0044783)
0.3 5.8 GO:0016237 membrane invagination(GO:0010324) lysosomal microautophagy(GO:0016237) single-organism membrane invagination(GO:1902534)
0.3 7.3 GO:0048468 ascospore formation(GO:0030437) cell development(GO:0048468)
0.3 1.0 GO:0045894 regulation of mating-type specific transcription from RNA polymerase II promoter(GO:0001196) negative regulation of mating-type specific transcription from RNA polymerase II promoter(GO:0001198) negative regulation of mating-type specific transcription, DNA-templated(GO:0045894)
0.3 1.9 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.3 5.3 GO:0045454 cell redox homeostasis(GO:0045454)
0.3 1.6 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.3 2.2 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.3 1.8 GO:0070096 mitochondrial outer membrane translocase complex assembly(GO:0070096)
0.3 0.6 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.3 1.2 GO:0046174 polyol catabolic process(GO:0046174)
0.3 1.7 GO:0006077 (1->6)-beta-D-glucan metabolic process(GO:0006077)
0.3 2.9 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.3 0.8 GO:0000161 MAPK cascade involved in osmosensory signaling pathway(GO:0000161)
0.3 1.8 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615) proton-transporting ATP synthase complex assembly(GO:0043461)
0.3 3.3 GO:0000742 karyogamy involved in conjugation with cellular fusion(GO:0000742)
0.3 1.5 GO:0045996 negative regulation of transcription by pheromones(GO:0045996) negative regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046020)
0.3 0.5 GO:0045991 carbon catabolite activation of transcription(GO:0045991)
0.2 0.7 GO:0030100 regulation of endocytosis(GO:0030100)
0.2 3.7 GO:0007129 synapsis(GO:0007129)
0.2 1.2 GO:0008053 mitochondrial fusion(GO:0008053)
0.2 0.5 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.2 0.2 GO:0001178 regulation of transcriptional start site selection at RNA polymerase II promoter(GO:0001178)
0.2 0.7 GO:0032365 intracellular lipid transport(GO:0032365)
0.2 2.8 GO:0030474 spindle pole body duplication(GO:0030474)
0.2 0.5 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.2 2.5 GO:0016925 protein sumoylation(GO:0016925)
0.2 0.6 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
0.2 1.9 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.2 1.1 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.2 1.0 GO:0009098 leucine biosynthetic process(GO:0009098)
0.2 2.5 GO:0009968 negative regulation of signal transduction(GO:0009968) negative regulation of signaling(GO:0023057)
0.2 0.2 GO:0042148 strand invasion(GO:0042148)
0.2 1.2 GO:0006276 plasmid maintenance(GO:0006276)
0.2 0.8 GO:0035753 maintenance of DNA trinucleotide repeats(GO:0035753)
0.2 0.8 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.2 0.6 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.2 0.2 GO:0072350 tricarboxylic acid metabolic process(GO:0072350)
0.2 0.8 GO:0000390 spliceosomal complex disassembly(GO:0000390)
0.2 0.3 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.2 1.6 GO:0031145 anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.2 1.6 GO:0016180 snRNA processing(GO:0016180)
0.2 1.4 GO:0006312 mitotic recombination(GO:0006312)
0.2 2.7 GO:0008645 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.2 0.2 GO:0016320 endoplasmic reticulum membrane fusion(GO:0016320)
0.1 0.4 GO:0035392 maintenance of chromatin silencing(GO:0006344) maintenance of chromatin silencing at telomere(GO:0035392)
0.1 0.4 GO:0097271 protein localization to bud neck(GO:0097271)
0.1 0.9 GO:0000103 sulfate assimilation(GO:0000103)
0.1 0.7 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 0.8 GO:0006452 translational frameshifting(GO:0006452)
0.1 0.1 GO:0006739 NADP metabolic process(GO:0006739)
0.1 1.1 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.1 0.8 GO:0030042 actin filament depolymerization(GO:0030042)
0.1 2.3 GO:0006986 response to unfolded protein(GO:0006986)
0.1 0.8 GO:0000080 mitotic G1 phase(GO:0000080) G1 phase(GO:0051318)
0.1 0.1 GO:0034398 telomere tethering at nuclear periphery(GO:0034398)
0.1 0.2 GO:0030048 actin filament-based movement(GO:0030048) actin filament-based transport(GO:0099515)
0.1 1.5 GO:0001558 regulation of cell growth(GO:0001558)
0.1 0.4 GO:0010994 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.1 0.4 GO:0007234 osmosensory signaling via phosphorelay pathway(GO:0007234)
0.1 0.8 GO:0006526 arginine biosynthetic process(GO:0006526)
0.1 0.2 GO:2001040 cellular response to drug(GO:0035690) regulation of response to drug(GO:2001023) positive regulation of response to drug(GO:2001025) regulation of cellular response to drug(GO:2001038) positive regulation of cellular response to drug(GO:2001040)
0.1 1.1 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.1 0.8 GO:0046854 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.1 3.2 GO:0043254 regulation of protein complex assembly(GO:0043254)
0.1 0.2 GO:0006826 iron ion transport(GO:0006826)
0.1 0.3 GO:0000751 mitotic cell cycle arrest in response to pheromone(GO:0000751) mitotic cell cycle arrest(GO:0071850)
0.1 0.6 GO:0000271 polysaccharide biosynthetic process(GO:0000271)
0.1 0.2 GO:0051664 nuclear pore distribution(GO:0031081) nuclear pore localization(GO:0051664)
0.1 0.2 GO:0051225 spindle assembly(GO:0051225)
0.1 0.4 GO:0090114 COPII-coated vesicle budding(GO:0090114)
0.1 2.3 GO:0006979 response to oxidative stress(GO:0006979)
0.1 0.4 GO:0033313 meiotic cell cycle checkpoint(GO:0033313) meiotic recombination checkpoint(GO:0051598)
0.1 0.3 GO:0019933 cAMP-mediated signaling(GO:0019933) cyclic-nucleotide-mediated signaling(GO:0019935)
0.1 0.3 GO:0070676 intralumenal vesicle formation(GO:0070676)
0.1 0.7 GO:0018208 protein peptidyl-prolyl isomerization(GO:0000413) peptidyl-proline modification(GO:0018208)
0.1 0.3 GO:0046777 protein autophosphorylation(GO:0046777)
0.1 0.1 GO:0018410 C-terminal protein amino acid modification(GO:0018410) post-translational protein modification(GO:0043687)
0.1 0.5 GO:0048278 vesicle docking(GO:0048278)
0.1 0.3 GO:0016233 telomere capping(GO:0016233)
0.1 0.3 GO:0045910 negative regulation of DNA recombination(GO:0045910)
0.0 0.2 GO:0006112 glycogen metabolic process(GO:0005977) energy reserve metabolic process(GO:0006112)
0.0 0.1 GO:0043096 purine nucleobase salvage(GO:0043096)
0.0 0.3 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.8 GO:0035825 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 0.1 GO:0000754 adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion(GO:0000754) adaptation of signaling pathway(GO:0023058)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.1 GO:0046461 triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)
0.0 0.1 GO:0046466 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.0 0.1 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0 0.1 GO:0048309 endoplasmic reticulum inheritance(GO:0048309)
0.0 0.1 GO:0006621 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.0 0.0 GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931)
0.0 0.1 GO:0015856 cytosine transport(GO:0015856) purine-containing compound transmembrane transport(GO:0072530)
0.0 0.0 GO:0010511 regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.0 0.1 GO:0000105 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.0 0.1 GO:0007323 peptide pheromone maturation(GO:0007323)
0.0 0.1 GO:0034401 chromatin organization involved in regulation of transcription(GO:0034401)
0.0 0.1 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.4 27.1 GO:0005640 nuclear outer membrane(GO:0005640)
5.3 21.3 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
4.6 60.2 GO:0005619 ascospore wall(GO:0005619)
3.7 11.0 GO:0045269 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
3.2 28.9 GO:0045277 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
3.2 9.5 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
3.0 8.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
2.7 13.7 GO:0045281 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
2.3 9.4 GO:0030287 cell wall-bounded periplasmic space(GO:0030287)
2.1 15.0 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
2.1 10.6 GO:0072380 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
2.1 14.7 GO:0034657 GID complex(GO:0034657)
1.9 90.7 GO:0031225 anchored component of membrane(GO:0031225)
1.9 15.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
1.8 10.8 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
1.8 18.0 GO:0098797 plasma membrane protein complex(GO:0098797)
1.7 5.2 GO:0031166 integral component of vacuolar membrane(GO:0031166)
1.7 15.1 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
1.7 5.0 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
1.7 6.6 GO:0031901 early endosome membrane(GO:0031901)
1.5 19.2 GO:0070469 respiratory chain(GO:0070469)
1.5 17.4 GO:0045259 mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259)
1.4 4.1 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
1.3 28.7 GO:0042763 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
1.2 4.8 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
1.2 3.5 GO:0035649 Nrd1 complex(GO:0035649)
1.1 5.5 GO:0034448 EGO complex(GO:0034448)
1.0 71.8 GO:0010008 endosome membrane(GO:0010008)
1.0 3.0 GO:0005784 Sec61 translocon complex(GO:0005784)
1.0 1.9 GO:0001400 mating projection base(GO:0001400)
0.9 101.8 GO:0098852 fungal-type vacuole membrane(GO:0000329) lytic vacuole membrane(GO:0098852)
0.9 2.6 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.9 6.0 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.8 23.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.8 4.0 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.7 2.2 GO:0098562 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.7 2.2 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.7 2.7 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.7 2.0 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.6 3.8 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.6 5.5 GO:0005770 late endosome(GO:0005770)
0.6 1.8 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.6 1.8 GO:0009353 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.6 4.0 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.5 3.1 GO:0008180 COP9 signalosome(GO:0008180)
0.5 8.8 GO:0070822 Sin3-type complex(GO:0070822)
0.5 72.1 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.5 1.8 GO:0008623 CHRAC(GO:0008623)
0.5 19.0 GO:0000323 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.4 4.5 GO:0005656 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.4 5.1 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.4 1.7 GO:0031932 TORC2 complex(GO:0031932) TOR complex(GO:0038201)
0.4 1.2 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.4 124.4 GO:0005886 plasma membrane(GO:0005886)
0.4 0.8 GO:0051233 spindle midzone(GO:0051233)
0.4 0.8 GO:0032126 eisosome(GO:0032126)
0.4 0.8 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.4 1.2 GO:0032807 DNA ligase IV complex(GO:0032807)
0.4 0.7 GO:0043291 RAVE complex(GO:0043291)
0.4 1.1 GO:0042597 periplasmic space(GO:0042597)
0.4 4.4 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.4 3.6 GO:0000782 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.3 10.6 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.3 3.5 GO:0030014 CCR4-NOT complex(GO:0030014)
0.3 0.9 GO:0030870 Mre11 complex(GO:0030870)
0.3 0.6 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.3 2.8 GO:0000812 Swr1 complex(GO:0000812)
0.3 2.0 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.2 1.2 GO:0000145 exocyst(GO:0000145)
0.2 0.7 GO:0033551 monopolin complex(GO:0033551)
0.2 3.5 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.2 4.1 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.2 11.5 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.2 0.9 GO:0032116 SMC loading complex(GO:0032116)
0.2 0.6 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.2 2.8 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.2 3.0 GO:0000124 SAGA complex(GO:0000124)
0.2 1.6 GO:0071014 U2-type catalytic step 2 spliceosome(GO:0071007) catalytic step 2 spliceosome(GO:0071013) post-mRNA release spliceosomal complex(GO:0071014)
0.2 2.9 GO:0005682 U5 snRNP(GO:0005682)
0.2 8.0 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.2 15.9 GO:0005740 mitochondrial envelope(GO:0005740)
0.2 2.6 GO:0005680 anaphase-promoting complex(GO:0005680)
0.2 0.8 GO:0032545 CURI complex(GO:0032545)
0.1 0.9 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836) Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.1 3.1 GO:0005576 extracellular region(GO:0005576)
0.1 0.5 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205) Sec62/Sec63 complex(GO:0031207)
0.1 1.0 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.1 0.4 GO:0032389 MutLalpha complex(GO:0032389)
0.1 0.5 GO:0000444 MIS12/MIND type complex(GO:0000444) nuclear MIS12/MIND complex(GO:0000818)
0.1 1.7 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 1.2 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.1 0.8 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 0.5 GO:0016592 mediator complex(GO:0016592)
0.1 0.8 GO:0000795 synaptonemal complex(GO:0000795)
0.1 41.3 GO:0005739 mitochondrion(GO:0005739)
0.1 0.3 GO:0016587 Isw1 complex(GO:0016587)
0.1 6.1 GO:0000793 condensed chromosome(GO:0000793)
0.1 0.6 GO:0035097 histone methyltransferase complex(GO:0035097) Set1C/COMPASS complex(GO:0048188)
0.1 0.4 GO:0031499 TRAMP complex(GO:0031499)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.3 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.1 GO:0044697 HICS complex(GO:0044697)
0.0 0.1 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.1 GO:0005845 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.2 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.2 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.0 GO:0009277 fungal-type cell wall(GO:0009277)
0.0 0.5 GO:0005934 cellular bud tip(GO:0005934)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
25.9 129.6 GO:0015295 solute:proton symporter activity(GO:0015295)
17.9 71.6 GO:0015343 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
7.8 23.5 GO:0004866 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
7.3 21.8 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
7.1 21.3 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
6.7 60.1 GO:0000293 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
6.6 26.3 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
5.3 21.3 GO:0004396 hexokinase activity(GO:0004396)
5.1 20.5 GO:0005471 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
4.4 17.6 GO:0005537 mannose binding(GO:0005537)
4.3 17.3 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
3.9 11.8 GO:0048038 quinone binding(GO:0048038)
3.5 10.6 GO:0016289 CoA hydrolase activity(GO:0016289)
3.5 20.9 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
3.4 13.7 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
3.2 16.1 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
3.1 9.2 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
2.9 2.9 GO:0042947 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
2.9 28.9 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
2.9 17.2 GO:0090599 alpha-glucosidase activity(GO:0090599)
2.7 8.1 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
2.7 18.9 GO:0016833 oxo-acid-lyase activity(GO:0016833)
2.6 10.6 GO:0016615 malate dehydrogenase activity(GO:0016615)
2.6 7.9 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
2.6 28.8 GO:0015293 symporter activity(GO:0015293)
2.5 10.0 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
2.3 11.3 GO:0004559 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
2.2 13.2 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
2.2 2.2 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
2.1 8.5 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
2.1 12.7 GO:0005102 receptor binding(GO:0005102)
2.1 6.3 GO:1901474 azole transmembrane transporter activity(GO:1901474)
2.1 6.3 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
2.1 10.5 GO:0008171 O-methyltransferase activity(GO:0008171)
2.0 11.9 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
1.9 13.5 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
1.9 11.6 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
1.9 5.6 GO:0003954 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
1.8 12.9 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
1.8 1.8 GO:0019902 protein phosphatase 1 binding(GO:0008157) phosphatase binding(GO:0019902) protein phosphatase binding(GO:0019903)
1.8 17.7 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
1.8 15.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
1.7 5.2 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
1.7 18.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
1.7 6.6 GO:0008198 ferrous iron binding(GO:0008198)
1.7 11.6 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
1.6 4.8 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
1.6 3.1 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
1.6 4.7 GO:0005536 glucose binding(GO:0005536)
1.5 9.2 GO:0000400 four-way junction DNA binding(GO:0000400)
1.5 11.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
1.5 13.2 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
1.4 2.8 GO:0046915 transition metal ion transmembrane transporter activity(GO:0046915)
1.4 11.1 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
1.3 9.1 GO:0004364 glutathione transferase activity(GO:0004364)
1.3 22.5 GO:0050661 NADP binding(GO:0050661)
1.2 10.7 GO:0016413 O-acetyltransferase activity(GO:0016413)
1.2 4.7 GO:0008236 serine-type peptidase activity(GO:0008236)
1.1 11.5 GO:0004177 aminopeptidase activity(GO:0004177)
1.1 13.2 GO:0022838 substrate-specific channel activity(GO:0022838)
1.1 2.2 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
1.1 5.5 GO:0050308 sugar-phosphatase activity(GO:0050308)
1.0 5.2 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
1.0 14.7 GO:0016684 peroxidase activity(GO:0004601) oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)
1.0 6.2 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
1.0 8.1 GO:0031072 heat shock protein binding(GO:0031072)
1.0 2.0 GO:0022821 potassium:proton antiporter activity(GO:0015386) potassium ion antiporter activity(GO:0022821)
1.0 24.2 GO:0003684 damaged DNA binding(GO:0003684)
0.9 15.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.9 14.7 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.9 3.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.9 3.5 GO:0015085 calcium ion transmembrane transporter activity(GO:0015085)
0.9 20.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.9 2.6 GO:0030332 cyclin binding(GO:0030332)
0.8 5.8 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.8 4.1 GO:0016530 metallochaperone activity(GO:0016530)
0.8 2.4 GO:0004458 D-lactate dehydrogenase (cytochrome) activity(GO:0004458)
0.8 4.0 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.8 2.4 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.8 0.8 GO:0005078 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.8 3.9 GO:0016782 transferase activity, transferring sulfur-containing groups(GO:0016782) sulfurtransferase activity(GO:0016783)
0.8 6.0 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.7 3.7 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.7 5.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.7 2.0 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.6 5.8 GO:0000149 SNARE binding(GO:0000149)
0.6 7.0 GO:0015297 antiporter activity(GO:0015297)
0.6 5.7 GO:0005507 copper ion binding(GO:0005507)
0.6 5.6 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.6 0.6 GO:0022829 porin activity(GO:0015288) wide pore channel activity(GO:0022829)
0.6 2.4 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.6 3.0 GO:0052742 phosphatidylinositol kinase activity(GO:0052742)
0.6 1.2 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.6 6.6 GO:0060089 receptor activity(GO:0004872) transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) molecular transducer activity(GO:0060089) transmembrane receptor activity(GO:0099600)
0.6 1.8 GO:0008902 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.6 1.7 GO:0008169 C-methyltransferase activity(GO:0008169)
0.6 2.2 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.6 5.0 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.6 2.2 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.6 1.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.6 2.2 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.5 4.9 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.5 27.1 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
0.5 3.2 GO:0015291 secondary active transmembrane transporter activity(GO:0015291)
0.5 1.1 GO:0016208 AMP binding(GO:0016208)
0.5 9.9 GO:0004221 obsolete ubiquitin thiolesterase activity(GO:0004221)
0.5 32.5 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.5 28.4 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.5 2.0 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.5 4.0 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.5 5.0 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.5 1.0 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.5 1.0 GO:0045118 azole transporter activity(GO:0045118)
0.5 1.5 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.5 4.4 GO:0051184 cofactor transporter activity(GO:0051184)
0.5 2.0 GO:0043141 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.4 1.3 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.4 2.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.4 1.2 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.4 2.0 GO:0019789 SUMO transferase activity(GO:0019789)
0.4 14.0 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.4 1.2 GO:0033592 RNA strand annealing activity(GO:0033592) annealing activity(GO:0097617)
0.4 1.1 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.3 1.0 GO:0001132 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132)
0.3 2.8 GO:0035064 methylated histone binding(GO:0035064)
0.3 7.2 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.3 7.2 GO:0003678 DNA helicase activity(GO:0003678)
0.3 0.9 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.3 0.6 GO:0001026 transcription factor activity, core RNA polymerase III binding(GO:0000995) TFIIIB-type transcription factor activity(GO:0001026)
0.3 20.1 GO:0051082 unfolded protein binding(GO:0051082)
0.3 0.6 GO:0032452 histone demethylase activity(GO:0032452)
0.3 4.6 GO:0003688 DNA replication origin binding(GO:0003688)
0.3 1.4 GO:0050253 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.3 4.5 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.3 1.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.3 0.8 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.3 6.7 GO:0004871 signal transducer activity(GO:0004871)
0.3 0.8 GO:0015079 potassium ion transmembrane transporter activity(GO:0015079)
0.3 1.8 GO:0022890 inorganic cation transmembrane transporter activity(GO:0022890)
0.2 1.5 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.2 0.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 1.1 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.2 1.9 GO:0045182 translation regulator activity(GO:0045182)
0.2 3.4 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.2 0.8 GO:0019776 Atg8 ligase activity(GO:0019776)
0.2 2.8 GO:0004857 enzyme inhibitor activity(GO:0004857)
0.2 1.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 0.9 GO:0030246 carbohydrate binding(GO:0030246)
0.2 1.9 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors(GO:0016645)
0.2 0.7 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.2 2.9 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.2 3.8 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.2 0.7 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.2 1.6 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.2 3.2 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 1.1 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.1 0.1 GO:0017171 serine hydrolase activity(GO:0017171)
0.1 7.0 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 0.2 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.1 0.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 1.8 GO:0031491 nucleosome binding(GO:0031491)
0.1 0.3 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.1 0.3 GO:0043047 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.1 0.5 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.1 0.5 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 0.4 GO:0030983 mismatched DNA binding(GO:0030983)
0.1 4.8 GO:0005543 phospholipid binding(GO:0005543)
0.1 0.3 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.1 GO:0042736 NAD+ kinase activity(GO:0003951) NADH kinase activity(GO:0042736)
0.0 1.8 GO:0003682 chromatin binding(GO:0003682)
0.0 0.1 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.0 0.8 GO:0003712 transcription cofactor activity(GO:0003712)
0.0 0.4 GO:0051020 GTPase binding(GO:0051020)
0.0 0.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.1 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.1 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.0 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 14.3 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
3.5 13.9 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
3.1 9.4 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
3.1 6.2 PID IL4 2PATHWAY IL4-mediated signaling events
1.9 5.6 PID AR PATHWAY Coregulation of Androgen receptor activity
1.3 1.3 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
1.2 9.5 PID FANCONI PATHWAY Fanconi anemia pathway
1.1 1.1 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.9 1.8 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.9 5.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.7 1.4 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.5 770.8 ST G ALPHA I PATHWAY G alpha i Pathway
0.5 0.5 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.5 1.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4 1.2 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.4 0.4 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.2 0.8 PID P73PATHWAY p73 transcription factor network
0.1 0.4 NABA CORE MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.0 0.1 PID FOXO PATHWAY FoxO family signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 10.1 REACTOME PI3K EVENTS IN ERBB2 SIGNALING Genes involved in PI3K events in ERBB2 signaling
2.5 10.0 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
1.2 3.7 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.9 8.1 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.9 10.7 REACTOME DNA REPAIR Genes involved in DNA Repair
0.9 0.9 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.7 2.2 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.6 3.8 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.5 4.7 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.5 770.8 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.5 1.4 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.4 1.3 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.4 0.8 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.4 1.1 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.3 1.3 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.2 2.9 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1 0.9 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 0.3 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.1 0.3 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.1 REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES Genes involved in Transmembrane transport of small molecules