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Results for PUT3

Z-value: 0.69

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Transcription factors associated with PUT3

Gene Symbol Gene ID Gene Info
PUT3
S000001498 Transcriptional activator of proline utilization genes, constitutivel

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PUT3YKL015W0.706.0e-05Click!

Activity profile of PUT3 motif

Sorted Z-values of PUT3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YAR035W 3.93
YAT1
Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
YMR017W 3.79
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YPL026C 3.28
SKS1
Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YIL057C 2.94 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YAR053W 2.92 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR377C 2.85
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YJR048W 2.56
CYC1
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YJR095W 2.39
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YPL024W 2.34
RMI1
Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YJL045W 1.95 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YNL117W 1.93
MLS1
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YOR348C 1.81
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YKL163W 1.80
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YKL109W 1.80
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YHR212W-A 1.66 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YDR275W 1.65
BSC2
Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
YAR060C 1.65 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR096C 1.64
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YBL064C 1.63
PRX1
Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress; phosphorylated
YCR007C 1.55 Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YDR536W 1.48
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YHR212C 1.34 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR040W 1.34
YET2
Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
YFR053C 1.31
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YLR174W 1.30
IDP2
Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
YBL015W 1.29
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YPR007C 1.27
REC8
Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p
YPL061W 1.24
ALD6
Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress
YDL138W 1.23
RGT2
Plasma membrane glucose receptor, highly similar to Snf3p; both Rgt2p and Snf3p serve as transmembrane glucose sensors generating an intracellular signal that induces expression of glucose transporter (HXT) genes
YGR243W 1.22
FMP43
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNR073C 1.22 Putative mannitol dehydrogenase
YBR230C 1.20
OM14
Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron
YGL183C 1.18
MND1
Protein required for recombination and meiotic nuclear division; forms a complex with Hop2p, which is involved in chromosome pairing and repair of meiotic double-strand breaks
YDR313C 1.16
PIB1
RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain
YOR152C 1.13 Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YER067C-A 1.10 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
YLR296W 1.09 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPR169W-A 1.08 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps two other dubious ORFs: YPR170C and YPR170W-B
YDR216W 1.08
ADR1
Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
YMR081C 1.06
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YOR120W 1.04
GCY1
Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family
YNL305C 1.01 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL305C is not an essential gene
YIL024C 1.00 Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p
YGR032W 0.97
GSC2
Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
YGL033W 0.95
HOP2
Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
YER150W 0.95
SPI1
GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YGL191W 0.93
COX13
Subunit VIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP
YPL156C 0.93
PRM4
Pheromone-regulated protein, predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift
YHR126C 0.92 Putative protein of unknown function; transcription dependent upon Azf1p
YGL193C 0.91 Haploid-specific gene repressed by a1-alpha2, turned off in sir3 null strains, absence enhances the sensitivity of rad52-327 cells to campothecin almost 100-fold
YPL230W 0.90
USV1
Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in protein folding, ATP binding, and cell wall biosynthesis
YEL070W 0.90
DSF1
Deletion suppressor of mpt5 mutation
YNL180C 0.89
RHO5
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
YDR077W 0.89
SED1
Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites
YDL139C 0.89
SCM3
Nonhistone component of centromeric chromatin that binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; contains nuclear export signal (NES); required for G2/M progression and localization of Cse4p
YBR144C 0.89 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene
YMR090W 0.88 Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR090W is not an essential gene
YDL244W 0.87
THI13
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YDR178W 0.87
SDH4
Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YER015W 0.86
FAA2
Long chain fatty acyl-CoA synthetase; accepts a wider range of acyl chain lengths than Faa1p, preferring C9:0-C13:0; involved in the activation of endogenous pools of fatty acids
YNL144C 0.86 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YFR029W 0.86
PTR3
Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
YEL060C 0.86
PRB1
Vacuolar proteinase B (yscB), a serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation
YLR312C 0.85
QNQ1
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YPR036W-A 0.84 Protein of unknown function; transcription is regulated by Pdr1p
YNL179C 0.83 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
YAL054C 0.83
ACS1
Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YOR121C 0.82 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W
YHR139C 0.82
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YHR211W 0.81
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YDR277C 0.80
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YGL192W 0.80
IME4
Probable mRNA N6-adenosine methyltransferase that is required for IME1 transcript accumulation and for sporulation; expression is induced in starved MATa/MAT alpha diploid cells
YDR259C 0.80
YAP6
Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance
YDL020C 0.79
RPN4
Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses
YCR005C 0.78
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YGR286C 0.77
BIO2
Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant
YPR127W 0.76 Putative protein of unknown function; expression is activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YKL171W 0.76 Putative protein of unknown function; predicted protein kinase; implicated in proteasome function; epitope-tagged protein localizes to the cytoplasm
YLR055C 0.76
SPT8
Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
YMR016C 0.75
SOK2
Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; negatively regulates pseudohyphal differentiation; homologous to several transcription factors
YDR441C 0.75
APT2
Apparent pseudogene, not transcribed or translated under normal conditions; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity
YLR295C 0.74
ATP14
Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YBR230W-A 0.74 Putative protein of unknown function
YCL001W-B 0.74 Putative protein of unknown function; identified by homology
YML042W 0.71
CAT2
Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
YBL103C 0.70
RTG3
Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways
YMR002W 0.70
MIC17
Mitochondrial intermembrane space cysteine motif protein; MIC17 is not an essential gene
YNL190W 0.70 Cell wall protein of unknown function; proposed role as a hydrophilin induced by osmotic stress; contains a putative GPI-attachment site
YNL142W 0.69
MEP2
Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YPL062W 0.68 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation
YGL056C 0.68
SDS23
One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein, which genetic studies have implicated in APC/cyclosome regulation
YKL093W 0.68
MBR1
Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants
YDR096W 0.68
GIS1
JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1
YLR260W 0.67
LCB5
Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
YDR102C 0.67 Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index
YPL089C 0.66
RLM1
MADS-box transcription factor, component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p
YPR065W 0.65
ROX1
Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity
YPL025C 0.65 Hypothetical protein
YER103W 0.65
SSA4
Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation
YKR034W 0.65
DAL80
Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Deh1p
YDL223C 0.65
HBT1
Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
YMR103C 0.65 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR343C 0.64 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YDR406W 0.64
PDR15
Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
YBR280C 0.63
SAF1
F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1
YDR022C 0.63
CIS1
Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion
YGR039W 0.63 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722
YKL102C 0.61 Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
YML081C-A 0.61
ATP18
Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms
YIL125W 0.61
KGD1
Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA
YGL194C 0.60
HOS2
Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity
YDR452W 0.59
PPN1
Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer
YNL143C 0.59 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR161C 0.59
RTS3
Putative component of the protein phosphatase type 2A complex
YDR298C 0.58
ATP5
Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
YOL084W 0.58
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YFR012W 0.57 Putative protein of unknown function
YPR026W 0.57
ATH1
Acid trehalase required for utilization of extracellular trehalose
YGL035C 0.57
MIG1
Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase
YKR039W 0.56
GAP1
General amino acid permease; localization to the plasma membrane is regulated by nitrogen source
YLR124W 0.56 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR056W 0.56
RSC1
Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook
YBR051W 0.56 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase
YOR306C 0.55
MCH5
Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport
YMR141W-A 0.55 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene RPL13B/YMR142C
YBR180W 0.55
DTR1
Putative dityrosine transporter, required for spore wall synthesis; expressed during sporulation; member of the major facilitator superfamily (DHA1 family) of multidrug resistance transporters
YDR542W 0.54
PAU10
Hypothetical protein
YPR013C 0.54 Putative zinc finger protein; YPR013C is not an essential gene
YOR139C 0.53 Hypothetical protein
YBR297W 0.53
MAL33
MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C
YJL116C 0.52
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YDR442W 0.52 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR123C 0.52 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YOL138C 0.52
RTC1
Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; null mutation suppresses cdc13-1 temperature sensitivity
YOL051W 0.52
GAL11
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors
YDR223W 0.51
CRF1
Transcriptional corepressor involved in the regulation of ribosomal protein gene transcription via the TOR signaling pathway and protein kinase A, phosphorylated by activated Yak1p which promotes accumulation of Crf1p in the nucleus
YJR094C 0.51
IME1
Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
YLR122C 0.50 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YBR050C 0.50
REG2
Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
YOR140W 0.50
SFL1
Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p
YEL012W 0.50
UBC8
Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
YOR178C 0.49
GAC1
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YPL222C-A 0.49 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YEL049W 0.49
PAU2
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YKR100C 0.48
SKG1
Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell
YKL112W 0.48
ABF1
DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair
YOL085W-A 0.48 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YOL085C
YBR179C 0.48
FZO1
Mitochondrial integral membrane protein involved in mitochondrial fusion and maintenance of the mitochondrial genome; contains N-terminal GTPase domain
YDR242W 0.47
AMD2
Putative amidase
YBR021W 0.47
FUR4
Uracil permease, localized to the plasma membrane; expression is tightly regulated by uracil levels and environmental cues
YAL018C 0.47 Putative protein of unknown function
YDR171W 0.47
HSP42
Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock
YDR103W 0.46
STE5
Pheromone-response scaffold protein; binds kinases Ste11p, Ste7p, and Fus3p to form a MAPK cascade complex that interacts with the plasma membrane, via a PH (pleckstrin homology) and PM/NLS domain, and with Ste4p-Ste18p, during signaling
YCR033W 0.46
SNT1
Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein
YDL245C 0.46
HXT15
Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose
YDR036C 0.46
EHD3
3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis
YKR101W 0.45
SIR1
Protein involved in repression of transcription at the silent mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin
YPL088W 0.45 Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
YMR284W 0.45
YKU70
Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
YDL110C 0.45
TMA17
Protein of unknown function that associates with ribosomes
YHR210C 0.45 Putative protein of unknown function; non-essential gene; highly expressed under anaeorbic conditions; sequence similarity to aldose 1-epimerases such as GAL10
YGL133W 0.45
ITC1
Component of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1
YPL171C 0.45
OYE3
Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YLR383W 0.45
SMC6
Protein involved in structural maintenance of chromosomes; essential subunit of Mms21-Smc5-Smc6 complex; required for growth, DNA repair, interchromosomal and sister chromatid recombination; homologous to S. pombe rad18
YKR073C 0.44 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YER158C 0.44 Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p
YGL177W 0.44 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR402W 0.44 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR067C 0.44 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YMR280C 0.44
CAT8
Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements
YPR010C-A 0.44 Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YHR145C 0.43 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR371C 0.43
GPB1
Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb2p
YPL119C 0.43
DBP1
Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs
YDL181W 0.42
INH1
Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has similarity to Stf1p; has a calmodulin-binding motif and binds calmodulin in vitro
YGR045C 0.42 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR403W 0.42
SFP1
Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
YOR223W 0.42 Putative protein of unknown function
YGL117W 0.42 Putative protein of unknown function
YNL139C 0.42
THO2
Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids
YLR304C 0.42
ACO1
Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy
YLR326W 0.41 Hypothetical protein
YLR390W-A 0.41
CCW14
Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall
YPL282C 0.40
PAU22
Hypothetical protein
YNL282W 0.40
POP3
Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YJR089W 0.40
BIR1
Essential chromosomal passenger protein involved in coordinating cell cycle events for proper chromosome segregation; C-terminal region binds Sli15p, and the middle region, upon phosphorylation, localizes Cbf2p to the spindle at anaphase
YPL262W 0.40
FUM1
Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation; phosphorylated in mitochondria
YGR046W 0.40
TAM41
Mitochondrial protein involved in protein import into the mitochondrial matrix; maintains the functional integrity of the TIM23 protein translocator complex; viability of null mutant is strain-dependent; mRNA is targeted to the bud
YOR235W 0.40
IRC13
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci
YKR011C 0.40 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YAL039C 0.39
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YFL013W-A 0.39 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps IES1/YFL013C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
YKL217W 0.39
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YOR394W 0.39
PAU21
Hypothetical protein
YGR144W 0.39
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YMR124W 0.38 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene
YMR194C-B 0.38 Putative protein of unknown function
YOL055C 0.38
THI20
Multifunctional protein with both hydroxymethylpyrimidine kinase and thiaminase activities; involved in thiamine biosynthesis and also in thiamine degradation; member of a gene family with THI21 and THI22; functionally redundant with Thi21p
YDL010W 0.38
GRX6
Cis-golgi localized monothiol glutaredoxin that binds an iron-sulfur cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; functional overlap with GRX6
YML025C 0.38
YML6
Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins

Network of associatons between targets according to the STRING database.

First level regulatory network of PUT3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.6 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
0.8 2.3 GO:0034310 ethanol catabolic process(GO:0006068) primary alcohol catabolic process(GO:0034310)
0.7 2.2 GO:0015740 C4-dicarboxylate transport(GO:0015740)
0.7 8.0 GO:0015758 glucose transport(GO:0015758)
0.6 2.3 GO:0043388 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
0.5 4.8 GO:0006097 glyoxylate cycle(GO:0006097)
0.4 1.3 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.4 2.1 GO:0006083 acetate metabolic process(GO:0006083)
0.4 1.2 GO:0006850 mitochondrial pyruvate transport(GO:0006850)
0.4 0.4 GO:0006848 pyruvate transport(GO:0006848)
0.4 1.1 GO:0070304 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.3 1.0 GO:0042843 D-xylose catabolic process(GO:0042843)
0.3 1.4 GO:0015804 neutral amino acid transport(GO:0015804)
0.3 1.0 GO:0042126 nitrate metabolic process(GO:0042126) nitrate assimilation(GO:0042128)
0.3 2.7 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.3 0.9 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.3 1.5 GO:0015793 glycerol transport(GO:0015793)
0.3 1.7 GO:0043457 regulation of cellular respiration(GO:0043457)
0.3 0.3 GO:0036095 positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter(GO:0036095) positive regulation of invasive growth in response to glucose limitation(GO:2000219)
0.3 3.8 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.3 0.8 GO:0044209 AMP salvage(GO:0044209)
0.2 1.0 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.2 0.7 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.2 1.1 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.2 0.6 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.2 0.9 GO:0043200 response to amino acid(GO:0043200)
0.2 0.6 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.2 1.0 GO:0061416 regulation of transcription from RNA polymerase II promoter in response to salt stress(GO:0061416)
0.2 1.9 GO:0046686 response to cadmium ion(GO:0046686)
0.2 0.6 GO:0005993 trehalose catabolic process(GO:0005993)
0.2 2.8 GO:0072593 reactive oxygen species metabolic process(GO:0072593)
0.2 0.7 GO:0008214 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.2 1.3 GO:0051177 meiotic sister chromatid cohesion(GO:0051177)
0.2 2.2 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.2 0.9 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.2 0.5 GO:0006343 establishment of chromatin silencing(GO:0006343)
0.1 0.4 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.1 0.6 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.1 0.6 GO:0042173 regulation of sporulation resulting in formation of a cellular spore(GO:0042173)
0.1 1.2 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.1 2.2 GO:0001101 response to acid chemical(GO:0001101)
0.1 0.7 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.1 0.4 GO:0017006 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.1 0.4 GO:0036257 multivesicular body organization(GO:0036257)
0.1 0.8 GO:0009102 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.1 0.4 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
0.1 0.5 GO:0042357 thiamine diphosphate biosynthetic process(GO:0009229) thiamine diphosphate metabolic process(GO:0042357)
0.1 0.2 GO:0019629 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
0.1 0.7 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 0.2 GO:0042773 respiratory electron transport chain(GO:0022904) ATP synthesis coupled electron transport(GO:0042773) mitochondrial ATP synthesis coupled electron transport(GO:0042775)
0.1 0.7 GO:0071322 cellular response to carbohydrate stimulus(GO:0071322)
0.1 0.6 GO:0008053 mitochondrial fusion(GO:0008053)
0.1 0.2 GO:0006538 glutamate catabolic process(GO:0006538)
0.1 0.5 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.1 0.7 GO:0051180 vitamin transport(GO:0051180)
0.1 0.6 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.1 0.4 GO:1900436 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
0.1 0.7 GO:0019722 calcium-mediated signaling(GO:0019722)
0.1 0.1 GO:1900544 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.1 0.1 GO:0071629 cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071629)
0.1 0.6 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.1 0.6 GO:0015851 nucleobase transport(GO:0015851)
0.1 1.2 GO:0000767 cell morphogenesis involved in conjugation with cellular fusion(GO:0000753) cell morphogenesis involved in conjugation(GO:0000767)
0.1 1.0 GO:0006099 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101)
0.1 4.0 GO:0009060 aerobic respiration(GO:0009060)
0.1 1.3 GO:0042724 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.1 0.5 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.1 0.9 GO:0046777 protein autophosphorylation(GO:0046777)
0.1 0.4 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.1 0.3 GO:0006545 glycine biosynthetic process(GO:0006545)
0.1 0.6 GO:0000023 maltose metabolic process(GO:0000023)
0.1 0.1 GO:0007032 endosome organization(GO:0007032)
0.1 0.4 GO:0031507 heterochromatin assembly(GO:0031507)
0.1 0.4 GO:0046058 cAMP metabolic process(GO:0046058)
0.1 0.2 GO:0006562 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
0.1 0.2 GO:0015937 coenzyme A biosynthetic process(GO:0015937) nucleoside bisphosphate biosynthetic process(GO:0033866) ribonucleoside bisphosphate biosynthetic process(GO:0034030) purine nucleoside bisphosphate biosynthetic process(GO:0034033)
0.1 0.9 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 0.5 GO:0001079 nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079)
0.1 0.2 GO:2000284 positive regulation of cellular amino acid metabolic process(GO:0045764) positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.1 0.2 GO:0010994 free ubiquitin chain polymerization(GO:0010994)
0.1 1.3 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 1.1 GO:0007129 synapsis(GO:0007129)
0.1 0.3 GO:0044247 glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.1 0.3 GO:0070813 hydrogen sulfide metabolic process(GO:0070813) hydrogen sulfide biosynthetic process(GO:0070814)
0.1 0.2 GO:0034395 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.1 0.2 GO:0051865 protein autoubiquitination(GO:0051865)
0.1 0.2 GO:0019346 transsulfuration(GO:0019346)
0.1 0.4 GO:0031134 sister chromatid biorientation(GO:0031134)
0.1 0.3 GO:0032075 positive regulation of nuclease activity(GO:0032075)
0.1 0.1 GO:0006527 arginine catabolic process(GO:0006527)
0.1 0.3 GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931)
0.1 0.3 GO:0034487 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.1 0.6 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.1 0.1 GO:0032006 regulation of TOR signaling(GO:0032006)
0.1 0.2 GO:0006827 high-affinity iron ion transmembrane transport(GO:0006827)
0.1 0.2 GO:0009411 response to UV(GO:0009411) response to light stimulus(GO:0009416)
0.1 0.2 GO:0051222 positive regulation of protein transport(GO:0051222) positive regulation of protein localization to nucleus(GO:1900182) positive regulation of cellular protein localization(GO:1903829) positive regulation of establishment of protein localization(GO:1904951)
0.1 0.3 GO:0070941 eisosome assembly(GO:0070941)
0.1 0.5 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.1 1.0 GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress(GO:0036003)
0.1 0.1 GO:0052547 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
0.1 0.2 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.1 0.3 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.1 0.2 GO:0015680 intracellular copper ion transport(GO:0015680)
0.1 0.2 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.1 0.3 GO:0070676 intralumenal vesicle formation(GO:0070676)
0.1 0.2 GO:0000821 regulation of glutamine family amino acid metabolic process(GO:0000820) regulation of arginine metabolic process(GO:0000821)
0.1 0.7 GO:1905037 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.0 0.4 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.0 0.2 GO:0098610 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.0 0.0 GO:0071406 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
0.0 0.1 GO:0016241 regulation of macroautophagy(GO:0016241)
0.0 0.2 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.0 0.1 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0 0.1 GO:0043954 cellular component maintenance(GO:0043954)
0.0 0.1 GO:0060194 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.0 0.1 GO:0071050 snoRNA polyadenylation(GO:0071050)
0.0 0.5 GO:0030474 spindle pole body duplication(GO:0030474)
0.0 0.2 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.0 0.2 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.0 0.1 GO:0019748 secondary metabolic process(GO:0019748)
0.0 0.2 GO:0009164 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.0 0.7 GO:0006915 apoptotic process(GO:0006915) cell death(GO:0008219) programmed cell death(GO:0012501)
0.0 0.3 GO:0045996 negative regulation of transcription by pheromones(GO:0045996) negative regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046020)
0.0 0.1 GO:1903313 positive regulation of mRNA metabolic process(GO:1903313)
0.0 0.1 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0 0.8 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.0 0.2 GO:0072668 obsolete tubulin complex biogenesis(GO:0072668)
0.0 1.4 GO:0010927 cellular component assembly involved in morphogenesis(GO:0010927)
0.0 0.1 GO:0000103 sulfate assimilation(GO:0000103)
0.0 0.3 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0 0.4 GO:0001934 positive regulation of protein phosphorylation(GO:0001934)
0.0 0.7 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.2 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.0 0.1 GO:0031292 gene conversion at mating-type locus, DNA double-strand break processing(GO:0031292) negative regulation of reciprocal meiotic recombination(GO:0045128)
0.0 0.1 GO:0008272 sulfate transport(GO:0008272)
0.0 0.2 GO:0051447 negative regulation of meiotic nuclear division(GO:0045835) negative regulation of meiotic cell cycle(GO:0051447)
0.0 0.1 GO:0072414 cellular response to biotic stimulus(GO:0071216) response to cell cycle checkpoint signaling(GO:0072396) response to mitotic cell cycle checkpoint signaling(GO:0072414) response to spindle checkpoint signaling(GO:0072417) response to mitotic spindle checkpoint signaling(GO:0072476) response to mitotic cell cycle spindle assembly checkpoint signaling(GO:0072479) response to spindle assembly checkpoint signaling(GO:0072485) negative regulation of protein import into nucleus during spindle assembly checkpoint(GO:1901925)
0.0 0.1 GO:0042938 dipeptide transport(GO:0042938)
0.0 0.1 GO:0048313 Golgi inheritance(GO:0048313)
0.0 0.1 GO:0060237 regulation of fungal-type cell wall organization(GO:0060237)
0.0 0.1 GO:0045144 meiosis II(GO:0007135) meiotic sister chromatid segregation(GO:0045144)
0.0 0.2 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.0 0.1 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 1.2 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 1.8 GO:0000122 negative regulation of transcription from RNA polymerase II promoter(GO:0000122)
0.0 0.6 GO:0000002 mitochondrial genome maintenance(GO:0000002)
0.0 0.3 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.0 0.3 GO:0000209 protein polyubiquitination(GO:0000209)
0.0 0.1 GO:0010511 regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.0 0.1 GO:0002188 translation reinitiation(GO:0002188)
0.0 0.6 GO:0000724 double-strand break repair via homologous recombination(GO:0000724)
0.0 0.2 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.0 0.9 GO:0007124 pseudohyphal growth(GO:0007124)
0.0 0.1 GO:0006598 polyamine catabolic process(GO:0006598)
0.0 0.2 GO:0070987 error-prone translesion synthesis(GO:0042276) error-free translesion synthesis(GO:0070987)
0.0 1.2 GO:0016567 protein ubiquitination(GO:0016567)
0.0 0.3 GO:0008645 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.0 0.1 GO:0072369 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.0 0.7 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.0 0.1 GO:0015891 siderophore transport(GO:0015891)
0.0 0.1 GO:0000372 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.0 0.0 GO:0046033 AMP biosynthetic process(GO:0006167) AMP metabolic process(GO:0046033)
0.0 0.1 GO:0072337 modified amino acid transport(GO:0072337)
0.0 0.1 GO:0018105 peptidyl-serine phosphorylation(GO:0018105) peptidyl-serine modification(GO:0018209)
0.0 0.1 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.2 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.0 0.1 GO:0043462 regulation of ATPase activity(GO:0043462)
0.0 0.1 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615) proton-transporting ATP synthase complex assembly(GO:0043461)
0.0 0.1 GO:0030100 regulation of endocytosis(GO:0030100)
0.0 0.1 GO:0000390 spliceosomal complex disassembly(GO:0000390)
0.0 0.1 GO:0008105 asymmetric protein localization(GO:0008105)
0.0 0.3 GO:1905039 organic acid transmembrane transport(GO:1903825) carboxylic acid transmembrane transport(GO:1905039)
0.0 0.1 GO:0007532 regulation of mating-type specific transcription, DNA-templated(GO:0007532)
0.0 0.1 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.0 0.1 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.5 GO:0006310 DNA recombination(GO:0006310)
0.0 0.1 GO:0034087 establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087)
0.0 0.1 GO:0001300 chronological cell aging(GO:0001300)
0.0 0.1 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.1 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.2 GO:0008361 regulation of cell size(GO:0008361)
0.0 0.1 GO:0035542 regulation of vesicle fusion(GO:0031338) regulation of SNARE complex assembly(GO:0035542)
0.0 0.1 GO:0055069 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.0 0.0 GO:0051098 regulation of binding(GO:0051098)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.5 2.0 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.4 2.8 GO:0042597 periplasmic space(GO:0042597)
0.2 1.0 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.2 2.0 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.2 1.1 GO:0045273 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.2 0.6 GO:0009353 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.2 0.6 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.2 0.9 GO:0005771 multivesicular body(GO:0005771)
0.2 1.7 GO:0031160 ascospore wall(GO:0005619) spore wall(GO:0031160)
0.2 4.0 GO:0070469 respiratory chain(GO:0070469)
0.2 1.3 GO:0034967 Set3 complex(GO:0034967)
0.2 1.4 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.2 0.7 GO:0097042 extrinsic component of fungal-type vacuolar membrane(GO:0097042)
0.2 0.3 GO:0001400 mating projection base(GO:0001400)
0.2 4.6 GO:0042763 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.1 1.6 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 0.4 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 0.6 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 0.4 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.1 0.5 GO:0008623 CHRAC(GO:0008623)
0.1 0.4 GO:0000446 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) nucleoplasmic THO complex(GO:0000446)
0.1 0.3 GO:0005756 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
0.1 0.3 GO:0005796 Golgi lumen(GO:0005796)
0.1 1.8 GO:0031307 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.1 0.3 GO:0032807 DNA ligase IV complex(GO:0032807)
0.1 0.3 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.1 0.3 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 0.2 GO:0032301 MutSalpha complex(GO:0032301)
0.1 0.3 GO:0005677 chromatin silencing complex(GO:0005677)
0.1 0.3 GO:0030907 MBF transcription complex(GO:0030907)
0.1 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 0.3 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
0.1 0.3 GO:0000815 ESCRT III complex(GO:0000815)
0.1 0.2 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 0.5 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.1 0.4 GO:0034657 GID complex(GO:0034657)
0.1 0.3 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 0.2 GO:0097002 mitochondrial inner boundary membrane(GO:0097002)
0.1 8.0 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 0.8 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.1 0.4 GO:0005724 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.0 0.1 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)
0.0 0.1 GO:0051286 cell tip(GO:0051286)
0.0 0.9 GO:0000124 SAGA complex(GO:0000124)
0.0 1.5 GO:0005770 late endosome(GO:0005770)
0.0 4.1 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 0.1 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0 1.2 GO:0031970 organelle envelope lumen(GO:0031970)
0.0 0.3 GO:0033101 cellular bud membrane(GO:0033101)
0.0 0.7 GO:0070847 core mediator complex(GO:0070847)
0.0 0.2 GO:0032221 Rpd3S complex(GO:0032221)
0.0 1.2 GO:0005811 lipid particle(GO:0005811)
0.0 0.2 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 2.4 GO:0005576 extracellular region(GO:0005576)
0.0 0.6 GO:0016586 RSC complex(GO:0016586)
0.0 0.2 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.0 0.0 GO:0046695 SLIK (SAGA-like) complex(GO:0046695)
0.0 0.2 GO:0098797 plasma membrane protein complex(GO:0098797)
0.0 0.1 GO:0005823 central plaque of spindle pole body(GO:0005823)
0.0 0.3 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.2 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 0.2 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.3 GO:0000812 Swr1 complex(GO:0000812)
0.0 1.3 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.1 GO:0032176 split septin rings(GO:0032176) cellular bud neck split septin rings(GO:0032177)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.5 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.2 GO:0005940 septin ring(GO:0005940) septin cytoskeleton(GO:0032156)
0.0 0.3 GO:0071012 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.0 0.5 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.1 GO:0042555 MCM complex(GO:0042555)
0.0 0.3 GO:0031261 DNA replication preinitiation complex(GO:0031261)
0.0 0.2 GO:0030677 ribonuclease P complex(GO:0030677)
0.0 0.2 GO:0033698 Rpd3L complex(GO:0033698)
0.0 0.2 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.1 GO:0030897 HOPS complex(GO:0030897)
0.0 0.0 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.1 GO:0000133 polarisome(GO:0000133)
0.0 0.1 GO:0042575 DNA polymerase complex(GO:0042575)
0.0 0.1 GO:0033100 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.0 0.1 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.1 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836) Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.2 GO:0098589 membrane region(GO:0098589)
0.0 0.0 GO:0051233 spindle midzone(GO:0051233)
0.0 0.2 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.0 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.0 GO:0031010 ISWI-type complex(GO:0031010)
0.0 0.0 GO:0098562 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.0 0.0 GO:0072380 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.6 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
0.6 2.4 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.6 1.7 GO:0016289 CoA hydrolase activity(GO:0016289)
0.6 2.2 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.5 2.7 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.5 1.4 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.4 1.3 GO:0005536 glucose binding(GO:0005536)
0.4 2.1 GO:0015295 solute:proton symporter activity(GO:0015295)
0.4 1.2 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.4 2.4 GO:0000400 four-way junction DNA binding(GO:0000400)
0.4 1.4 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.4 1.1 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
0.3 1.0 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.3 0.9 GO:0016880 acid-ammonia (or amide) ligase activity(GO:0016880)
0.3 0.9 GO:0048038 quinone binding(GO:0048038)
0.3 1.1 GO:0004396 hexokinase activity(GO:0004396)
0.3 1.0 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.2 1.9 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.2 1.6 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.2 0.9 GO:0005537 mannose binding(GO:0005537)
0.2 0.7 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.2 0.7 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 0.7 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.2 1.3 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.2 2.5 GO:0005199 structural constituent of cell wall(GO:0005199)
0.2 2.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.2 0.6 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.2 0.5 GO:0008902 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.2 4.0 GO:0005484 SNAP receptor activity(GO:0005484)
0.2 0.5 GO:0005078 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.2 0.8 GO:0016782 transferase activity, transferring sulfur-containing groups(GO:0016782)
0.1 0.4 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 2.7 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 0.7 GO:0015294 solute:cation symporter activity(GO:0015294)
0.1 0.4 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.1 0.5 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.1 1.8 GO:0015578 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.1 0.7 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.1 0.6 GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)(GO:0097372)
0.1 0.4 GO:0003954 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.6 GO:0008198 ferrous iron binding(GO:0008198)
0.1 1.2 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.1 1.0 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 1.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 0.5 GO:0051183 vitamin transporter activity(GO:0051183)
0.1 0.5 GO:0015038 peptide disulfide oxidoreductase activity(GO:0015037) glutathione disulfide oxidoreductase activity(GO:0015038)
0.1 1.2 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 0.3 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.1 0.1 GO:0042947 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.1 0.3 GO:0005057 receptor signaling protein activity(GO:0005057)
0.1 0.3 GO:0015343 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.1 0.4 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.1 0.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.6 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.1 0.4 GO:0004806 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.1 0.2 GO:0004864 protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
0.1 3.1 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 1.8 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 0.4 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.1 0.3 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.1 0.2 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 0.6 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
0.1 0.2 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.1 0.2 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.1 0.2 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
0.1 0.2 GO:0004180 carboxypeptidase activity(GO:0004180)
0.1 0.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 0.1 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 1.2 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.3 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 2.8 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 0.5 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.4 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.3 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.0 0.1 GO:0008169 C-methyltransferase activity(GO:0008169)
0.0 0.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.9 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.2 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.2 GO:0016531 copper chaperone activity(GO:0016531)
0.0 0.3 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.1 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.8 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.2 GO:0015923 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.0 0.2 GO:0008171 O-methyltransferase activity(GO:0008171)
0.0 0.4 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.1 GO:0032183 SUMO binding(GO:0032183)
0.0 0.1 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.0 0.1 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.0 0.2 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.0 0.3 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.1 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.0 0.1 GO:0000772 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.0 0.2 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 2.3 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.2 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.3 GO:0060089 receptor activity(GO:0004872) molecular transducer activity(GO:0060089)
0.0 1.6 GO:0003690 double-stranded DNA binding(GO:0003690)
0.0 3.0 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 0.1 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.8 GO:0001071 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 0.1 GO:0015440 peptide-transporting ATPase activity(GO:0015440)
0.0 0.4 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.7 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.0 0.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.1 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.0 0.2 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.0 0.3 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.4 GO:0050661 NADP binding(GO:0050661)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.2 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.2 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.0 0.3 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 0.1 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.0 0.2 GO:0001098 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0 0.0 GO:0015188 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.0 0.1 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.1 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 1.0 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.6 GO:0008094 DNA-dependent ATPase activity(GO:0008094)
0.0 0.1 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.0 0.1 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.0 GO:0045118 azole transporter activity(GO:0045118)
0.0 0.3 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.0 0.1 GO:0005507 copper ion binding(GO:0005507)
0.0 0.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.0 GO:0016417 S-acyltransferase activity(GO:0016417)
0.0 0.1 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.0 GO:0016530 metallochaperone activity(GO:0016530)
0.0 0.2 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.0 0.1 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.3 GO:0003743 translation initiation factor activity(GO:0003743)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 PID IL4 2PATHWAY IL4-mediated signaling events
0.3 0.9 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.3 2.3 PID FANCONI PATHWAY Fanconi anemia pathway
0.1 0.3 PID ATR PATHWAY ATR signaling pathway
0.1 0.1 PID CMYB PATHWAY C-MYB transcription factor network
0.1 0.3 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.2 PID P73PATHWAY p73 transcription factor network
0.0 0.2 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 15.6 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.4 1.3 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.3 2.8 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 1.2 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 0.3 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 0.3 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.1 0.3 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 0.2 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.1 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.0 0.2 REACTOME DNA REPAIR Genes involved in DNA Repair
0.0 0.3 REACTOME CHROMOSOME MAINTENANCE Genes involved in Chromosome Maintenance
0.0 0.2 REACTOME RNA POL II PRE TRANSCRIPTION EVENTS Genes involved in RNA Polymerase II Pre-transcription Events
0.0 0.1 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.1 REACTOME HEMOSTASIS Genes involved in Hemostasis
0.0 0.1 REACTOME DNA STRAND ELONGATION Genes involved in DNA strand elongation
0.0 0.1 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.0 REACTOME TRANSCRIPTION Genes involved in Transcription
0.0 15.6 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis