Results for PHO4

Z-value: 1.70

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Transcription factors associated with PHO4

Gene Symbol Gene ID Gene Info
S000001930 Basic helix-loop-helix (bHLH) transcription factor of the myc-family

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of PHO4 motif

Sorted Z-values of PHO4 motif

Promoter Log-likelihood Transcript Gene Gene Info
YOR348C 27.71 Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YPL250C 21.53 Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YPL223C 18.54 Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YCL040W 12.54 Glucokinase, catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources
YCL042W 12.06 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YBR296C 11.56 Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
YJR146W 10.48 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2
YMR194C-B 10.36 Putative protein of unknown function
YJL133C-A 10.12 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YMR081C 9.22 Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YAR053W 9.20 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL018W 9.04 Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly
YHR212C 8.98 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL104C 8.87 Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway
YOR346W 8.09 Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YPL222W 8.07 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR120W 7.87 Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family
YPR013C 7.74 Putative zinc finger protein; YPR013C is not an essential gene
YER065C 7.46 Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YAR060C 7.09 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJR115W 7.08 Putative protein of unknown function
YHR212W-A 7.02 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YOL154W 6.89 Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
YNL036W 6.88 Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway
YML120C 6.84 NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID
YOR345C 6.74 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YMR017W 6.63 Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YEL024W 6.57 Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration
YHR033W 6.49 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YDR171W 6.45 Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock
YPL222C-A 6.38 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YLR438W 6.35 L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive
YAL054C 6.25 Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YIL057C 6.14 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YDR536W 5.87 Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YMR195W 5.87 Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
YDR343C 5.73 High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YKL217W 5.58 Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YOR152C 5.52 Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YOR192C 5.48 Transporter of thiamine or related compound; shares sequence similarity with Thi7p
YLR437C-A 5.31 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CAR2/YLR438W
YHL036W 5.26 Low affinity methionine permease, similar to Mup1p
YDR342C 5.16 High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YOR343C 5.07 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YDL210W 5.04 Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YPR184W 5.03 Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria
YPL206C 5.01 Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs
YLR296W 4.95 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR072W 4.83 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YML089C 4.83 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YDR406W 4.76 Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
YBL015W 4.75 Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YOR192C-C 4.74 Putative protein of unknown function; identified by expression profiling and mass spectrometry
YJL067W 4.71 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL052W 4.70 Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
YFL030W 4.67 Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YJR150C 4.66 Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YLR295C 4.65 Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YJR147W 4.60 Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
YJR138W 4.60 Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane
YJL185C 4.52 Putative protein of unknown function; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene
YAR069C 4.49 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR211W 4.42 Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YAR070C 4.31 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR071C 4.23 High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
YAR068W 4.22 Fungal-specific protein of unknown function; induced in respiratory-deficient cells
YGL045W 4.22 Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF
YER088C 4.21 Protein of unknown function, involved in telomeric gene silencing and filamentation
YFL055W 4.16 Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition
YPR027C 4.15 Putative protein of unknown function
YOR072W-A 4.14 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR072W; originally identified by fungal homology and RT-PCR
YFR053C 4.12 Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YDR530C 4.12 Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa1p
YNL037C 4.10 Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle
YCR011C 4.04 Putative ATP-dependent permease of the ABC transporter family of proteins
YBR077C 3.94 Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
YJL116C 3.89 Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YMR271C 3.89 Minor orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; major OPRTase encoded by URA5
YJL130C 3.88 Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP
YJR137C 3.82 Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
YPL189C-A 3.78 Putative cytochrome oxidase assembly factor; identified by homology to Ashbya gossypii; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity
YMR306W 3.75 Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR067C 3.74 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YAR050W 3.70 Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YJL166W 3.68 Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
YAL039C 3.66 Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YPR030W 3.65 Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate
YMR165C 3.64 Mg2+-dependent phosphatidate (PA) phosphatase, catalyzes the dephosphorylation of PA to yield diacylglycerol and Pi, responsible for de novo lipid synthesis; homologous to mammalian lipin 1
YCL041C 3.64 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps both the verified gene PDI1/YCL043C and the uncharacterized gene YCL042W
YKL085W 3.60 Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated
YIL107C 3.59 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, has negligible fructose-2,6-bisphosphatase activity, transcriptional regulation involves protein kinase A
YNL063W 3.44 S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene
YDR377W 3.41 Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YJR151C 3.34 Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YAR035W 3.33 Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
YFR049W 3.31 Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36
YIL047C 3.31 Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency
YNL115C 3.28 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
YPR151C 3.20 Mitochondrial protein required for degradation of unstable forms of cytochrome c
YBL064C 3.17 Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress; phosphorylated
YLR136C 3.13 mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis
YGL255W 3.12 High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YDR022C 3.09 Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion
YDR043C 3.07 Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YPR196W 3.07 Putative maltose activator
YHR145C 3.01 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR065W 3.00 Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
YDR281C 2.99 Protein of unknown function, expression is regulated by phosphate levels
YPL240C 2.97 Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
YDR438W 2.97 Mitochondrial transporter repressible by thiamine
YAR047C 2.96 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL198C 2.96 Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein
YOR186W 2.95 Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent
YGR254W 2.92 Enolase I, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose
YFL024C 2.90 Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb
YKL016C 2.89 Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YAL018C 2.82 Putative protein of unknown function
YDL244W 2.74 Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YPR010C-A 2.73 Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YDR441C 2.72 Apparent pseudogene, not transcribed or translated under normal conditions; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity
YML042W 2.72 Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
YFR030W 2.69 Subunit alpha of assimilatory sulfite reductase, which is responsible for the conversion of sulfite into sulfide
YML090W 2.69 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YBR006W 2.68 Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm
YIL099W 2.67 Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
YPL092W 2.65 Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein
YLR332W 2.65 O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
YNL103W 2.61 Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
YER066W 2.58 Putative protein of unknown function; YER066W is not an essential gene
YLR331C 2.57 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
YBR284W 2.56 Putative protein of unknown function; YBR284W is not an essential gene; null mutant exhibits decreased resistance to rapamycin and wortmannin
YLR267W 2.55 Protein of unknown function, overproduction suppresses a pam1 slv3 double null mutation
YJL089W 2.55 C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus
YJL100W 2.54 Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
YCL054W 2.51 AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants
YEL008W 2.50 Hypothetical protein predicted to be involved in metabolism
YBR287W 2.49 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene
YAL062W 2.49 NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YFL019C 2.47 Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene
YLR297W 2.42 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YLR297W is not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation
YMR181C 2.39 Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); YMR181C is not an essential gene
YPL058C 2.38 Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity
YOR328W 2.36 ATP-binding cassette (ABC) transporter, multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p
YLR378C 2.36 Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER
YKR049C 2.33 Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJR048W 2.31 Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YIL055C 2.31 Putative protein of unknown function
YEL009C 2.30 Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YDR169C 2.29 Protein that binds Sin3p in a two-hybrid assay
YPL024W 2.28 Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YEL070W 2.27 Deletion suppressor of mpt5 mutation
YHR071W 2.26 Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity
YDR055W 2.26 Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1
YLR377C 2.25 Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YMR206W 2.25 Putative protein of unknown function; YMR206W is not an essential gene
YKL192C 2.24 Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p
YCR005C 2.23 Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YKR011C 2.22 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YLR379W 2.21 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential ORF SEC61/YLR378C
YOR378W 2.20 Putative protein of unknown function; belongs to the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
YOR235W 2.17 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci
YGR121C 2.16 Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YOR040W 2.15 Mitochondrial glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate
YER189W 2.13 Putative protein of unknown function
YPL271W 2.12 Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YDR059C 2.12 Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins, central component of the cellular stress response; expression is heat inducible
YBR145W 2.09 Alcohol dehydrogenase isoenzyme V; involved in ethanol production
YJL043W 2.08 Putative protein of unknown function; YJL043W is a non-essential gene
YNL180C 2.07 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
YNL283C 2.06 Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response
YBR250W 2.06 Protein of unknown function; associates with meiosis-specific protein Spo1p
YCR025C 2.06 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene
YML083C 2.06 Putative protein of unknown function; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
YJL151C 2.03 Integral membrane protein localized to vacuolar intralumenal vesicles, computational analysis of large-scale protein-protein interaction data suggests a possible role in either cell wall synthesis or protein-vacuolar targeting
YBR035C 2.03 Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism
YGR043C 2.01 Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity
YJL217W 2.01 Cytoplasmic protein of unknown function; expression induced by calcium shortage and via the copper sensing transciption factor Mac1p during conditons of copper deficiency; mRNA is cell cycle regulated, peaking in G1 phase
YMR253C 1.99 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene
YML122C 1.99 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YER033C 1.98 Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency
YBR105C 1.97 Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; involved in proteasome-dependent catabolite degradation of FBPase
YMR107W 1.96 Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YLR356W 1.96 Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YHR138C 1.95 Putative protein of unknown function; has similarity to Pbi2p; double null mutant lacking Pbi2p and Yhr138p exhibits highly fragmented vacuoles
YJL068C 1.95 Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
YHR210C 1.94 Putative protein of unknown function; non-essential gene; highly expressed under anaeorbic conditions; sequence similarity to aldose 1-epimerases such as GAL10
YOR023C 1.94 Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex
YFR015C 1.93 Glycogen synthase with similarity to Gsy2p, the more highly expressed yeast homolog; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase
YER163C 1.91 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YOL060C 1.91 Protein required for normal mitochondrial morphology, has similarity to hemolysins
YPR028W 1.90 Membrane protein that interacts with Yip1p to mediate membrane traffic; overexpression results in cell death and accumulation of internal cell membranes; regulates vesicular traffic in stressed cells
YNL240C 1.90 Nuclear architecture related protein; component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins; homologous to human Narf
YLR054C 1.90 Protein of unknown function proposed to be involved in the assembly of the spore wall
YBR033W 1.90 Putative zinc cluster protein; YBR033W is not an essential gene
YHR159W 1.88 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate
YOR010C 1.88 Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis
YER014C-A 1.88 Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YIL101C 1.87 Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate
YNL179C 1.86 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
YDR504C 1.85 Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources

Network of associatons between targets according to the STRING database.

First level regulatory network of PHO4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.1 28.4 GO:0015804 neutral amino acid transport(GO:0015804)
4.4 17.5 GO:0046323 glucose import(GO:0046323)
3.5 10.5 GO:0042843 D-xylose catabolic process(GO:0042843)
3.3 10.0 GO:0015888 thiamine transport(GO:0015888)
2.3 6.8 GO:0043068 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
2.0 4.1 GO:0006102 isocitrate metabolic process(GO:0006102)
2.0 6.1 GO:0006545 glycine biosynthetic process(GO:0006545)
2.0 6.1 GO:0006577 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
1.7 8.6 GO:0005980 glycogen catabolic process(GO:0005980)
1.7 6.9 GO:0015976 carbon utilization(GO:0015976)
1.6 16.4 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
1.6 6.6 GO:0006527 arginine catabolic process(GO:0006527)
1.6 1.6 GO:0034310 ethanol catabolic process(GO:0006068) primary alcohol catabolic process(GO:0034310)
1.5 8.7 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
1.4 5.6 GO:0006848 pyruvate transport(GO:0006848)
1.4 4.1 GO:0006108 malate metabolic process(GO:0006108)
1.3 4.0 GO:0017006 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
1.3 9.1 GO:0006083 acetate metabolic process(GO:0006083)
1.3 7.8 GO:0044205 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
1.3 2.6 GO:0035948 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
1.2 1.2 GO:0051222 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
1.2 6.0 GO:0015793 glycerol transport(GO:0015793)
1.1 3.3 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
1.1 9.8 GO:0006097 glyoxylate cycle(GO:0006097)
1.0 7.3 GO:0009098 leucine biosynthetic process(GO:0009098)
1.0 4.1 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
1.0 4.0 GO:0015847 putrescine transport(GO:0015847)
1.0 13.9 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
1.0 23.5 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
1.0 2.9 GO:0072353 cellular age-dependent response to reactive oxygen species(GO:0072353)
0.9 4.7 GO:0032105 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.9 3.7 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.9 2.7 GO:0006003 fructose metabolic process(GO:0006000) fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.9 8.1 GO:0070987 error-free translesion synthesis(GO:0070987)
0.9 8.0 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.9 2.7 GO:0006538 glutamate catabolic process(GO:0006538)
0.9 1.7 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.9 2.6 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.8 3.3 GO:0019184 glutathione biosynthetic process(GO:0006750) nonribosomal peptide biosynthetic process(GO:0019184)
0.8 3.1 GO:0043388 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
0.7 2.2 GO:0009106 lipoate metabolic process(GO:0009106) lipoate biosynthetic process(GO:0009107)
0.7 10.4 GO:0034085 establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087)
0.7 2.9 GO:0042743 hydrogen peroxide metabolic process(GO:0042743)
0.7 3.5 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.7 2.6 GO:0030969 mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response(GO:0030969) IRE1-mediated unfolded protein response(GO:0036498) mRNA splicing, via endonucleolytic cleavage and ligation(GO:0070054)
0.7 2.0 GO:0051469 vesicle fusion with vacuole(GO:0051469)
0.6 3.8 GO:1901658 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.6 2.5 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.6 2.4 GO:0034389 lipid particle organization(GO:0034389)
0.6 1.2 GO:1900544 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.6 2.4 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970) endoplasmic reticulum to cytosol transport(GO:1903513)
0.6 17.1 GO:0098656 anion transmembrane transport(GO:0098656)
0.6 1.7 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
0.6 1.7 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.6 0.6 GO:0006824 cobalt ion transport(GO:0006824)
0.5 1.1 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.5 4.2 GO:0006829 zinc II ion transport(GO:0006829)
0.5 5.7 GO:0046686 response to cadmium ion(GO:0046686)
0.5 2.0 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.5 2.9 GO:0016241 positive regulation of macroautophagy(GO:0016239) regulation of macroautophagy(GO:0016241)
0.5 9.4 GO:0008645 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.5 1.4 GO:0006883 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.5 0.9 GO:0006754 ATP biosynthetic process(GO:0006754)
0.4 3.6 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.4 2.2 GO:0034627 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.4 1.3 GO:1900371 regulation of cyclic nucleotide metabolic process(GO:0030799) regulation of cyclic nucleotide biosynthetic process(GO:0030802) regulation of nucleotide biosynthetic process(GO:0030808) regulation of cAMP metabolic process(GO:0030814) regulation of cAMP biosynthetic process(GO:0030817) regulation of purine nucleotide biosynthetic process(GO:1900371)
0.4 1.3 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.4 0.4 GO:0034503 protein localization to nucleolar rDNA repeats(GO:0034503)
0.4 1.6 GO:0032371 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.4 7.2 GO:0045991 carbon catabolite activation of transcription(GO:0045991)
0.4 1.2 GO:0015693 magnesium ion transport(GO:0015693)
0.4 4.3 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.4 1.8 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.4 1.1 GO:0001666 response to hypoxia(GO:0001666)
0.3 2.1 GO:0051292 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.3 1.4 GO:0015886 heme transport(GO:0015886)
0.3 3.4 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.3 2.7 GO:0042819 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.3 2.4 GO:0006855 drug transmembrane transport(GO:0006855)
0.3 5.0 GO:0072350 tricarboxylic acid metabolic process(GO:0072350)
0.3 3.3 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.3 4.9 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.3 1.0 GO:0005993 trehalose catabolic process(GO:0005993)
0.3 1.9 GO:0055071 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.3 2.5 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.3 1.6 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
0.3 2.7 GO:0072348 sulfur compound transport(GO:0072348)
0.3 0.9 GO:0045596 negative regulation of cell differentiation(GO:0045596)
0.3 9.6 GO:0009060 aerobic respiration(GO:0009060)
0.3 2.5 GO:0031167 rRNA methylation(GO:0031167)
0.3 3.6 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.3 1.3 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.3 1.3 GO:0005985 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.3 1.0 GO:0006089 lactate metabolic process(GO:0006089)
0.3 1.3 GO:0018344 protein geranylgeranylation(GO:0018344)
0.3 1.0 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.2 0.5 GO:0015680 intracellular copper ion transport(GO:0015680)
0.2 1.5 GO:0000272 polysaccharide catabolic process(GO:0000272)
0.2 1.2 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.2 0.7 GO:0006592 ornithine biosynthetic process(GO:0006592)
0.2 1.0 GO:0019405 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.2 0.5 GO:0042148 strand invasion(GO:0042148)
0.2 0.9 GO:0071322 cellular response to carbohydrate stimulus(GO:0071322)
0.2 1.4 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.2 1.6 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.2 1.1 GO:0046033 AMP biosynthetic process(GO:0006167) AMP metabolic process(GO:0046033)
0.2 0.7 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.2 4.9 GO:0007266 Rho protein signal transduction(GO:0007266)
0.2 4.1 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.2 1.7 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.2 1.5 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.2 1.7 GO:0006826 iron ion transport(GO:0006826)
0.2 1.0 GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931)
0.2 0.2 GO:0045836 positive regulation of meiotic nuclear division(GO:0045836) positive regulation of meiotic cell cycle(GO:0051446)
0.2 0.6 GO:0044783 G1 DNA damage checkpoint(GO:0044783)
0.2 0.6 GO:0006598 polyamine catabolic process(GO:0006598)
0.2 0.6 GO:0010466 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
0.2 2.6 GO:0006098 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.2 5.2 GO:0022900 electron transport chain(GO:0022900)
0.2 0.5 GO:0008216 spermidine metabolic process(GO:0008216)
0.2 1.8 GO:0044088 regulation of vacuole fusion, non-autophagic(GO:0032889) regulation of vacuole organization(GO:0044088)
0.2 1.0 GO:0009231 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.2 0.8 GO:0009113 purine nucleobase biosynthetic process(GO:0009113)
0.2 0.6 GO:0016578 histone deubiquitination(GO:0016578)
0.2 0.8 GO:0000023 maltose metabolic process(GO:0000023)
0.2 0.5 GO:0010039 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.2 1.1 GO:0000196 MAPK cascade involved in cell wall organization or biogenesis(GO:0000196)
0.2 0.6 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
0.2 1.5 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 0.6 GO:0009395 phospholipid catabolic process(GO:0009395)
0.1 0.9 GO:0006077 (1->6)-beta-D-glucan metabolic process(GO:0006077)
0.1 0.3 GO:0001178 regulation of transcriptional start site selection at RNA polymerase II promoter(GO:0001178)
0.1 0.5 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.1 0.5 GO:0006828 manganese ion transport(GO:0006828)
0.1 0.9 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.1 1.2 GO:0031070 intronic snoRNA processing(GO:0031070) intronic box C/D snoRNA processing(GO:0034965)
0.1 0.3 GO:0019856 pyrimidine nucleobase biosynthetic process(GO:0019856)
0.1 0.5 GO:0015855 pyrimidine nucleobase transport(GO:0015855)
0.1 3.4 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.1 0.7 GO:0015802 basic amino acid transport(GO:0015802)
0.1 0.2 GO:0051098 regulation of binding(GO:0051098)
0.1 3.2 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.1 1.1 GO:0000767 cell morphogenesis involved in conjugation with cellular fusion(GO:0000753) cell morphogenesis involved in conjugation(GO:0000767)
0.1 0.4 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.1 0.4 GO:0070940 promoter clearance during DNA-templated transcription(GO:0001109) promoter clearance from RNA polymerase II promoter(GO:0001111) dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.1 0.6 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.1 0.3 GO:0034086 maintenance of sister chromatid cohesion(GO:0034086)
0.1 0.3 GO:0032056 positive regulation of translation in response to stress(GO:0032056)
0.1 1.7 GO:0015918 sterol transport(GO:0015918)
0.1 0.3 GO:0030149 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.1 0.4 GO:0051260 protein homooligomerization(GO:0051260)
0.1 0.4 GO:0055088 lipid homeostasis(GO:0055088)
0.1 0.4 GO:0031507 heterochromatin assembly(GO:0031507)
0.1 0.2 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.1 0.3 GO:0099515 actin filament-based movement(GO:0030048) actin filament-based transport(GO:0099515)
0.1 0.4 GO:0006655 phosphatidylglycerol biosynthetic process(GO:0006655) cardiolipin metabolic process(GO:0032048)
0.1 0.4 GO:0043112 receptor recycling(GO:0001881) protein import into peroxisome matrix, receptor recycling(GO:0016562) receptor metabolic process(GO:0043112)
0.1 0.4 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 1.6 GO:0031503 protein complex localization(GO:0031503)
0.1 2.9 GO:0070726 cell wall assembly(GO:0070726)
0.1 1.4 GO:0006986 response to unfolded protein(GO:0006986)
0.1 0.8 GO:0006865 amino acid transport(GO:0006865)
0.1 0.2 GO:0043200 response to amino acid(GO:0043200)
0.1 0.4 GO:0070124 mitochondrial translational initiation(GO:0070124)
0.1 0.4 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.1 1.1 GO:0009062 fatty acid catabolic process(GO:0009062)
0.1 1.6 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.1 0.2 GO:0006768 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.1 0.2 GO:0010994 free ubiquitin chain polymerization(GO:0010994)
0.1 0.2 GO:0034398 telomere tethering at nuclear periphery(GO:0034398)
0.1 0.6 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.1 0.2 GO:0019433 triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)
0.1 0.2 GO:0043937 regulation of sporulation(GO:0043937)
0.1 0.2 GO:0016577 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.1 0.4 GO:0000376 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.1 0.3 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.1 0.3 GO:0007534 gene conversion at mating-type locus(GO:0007534)
0.0 0.2 GO:0030100 regulation of endocytosis(GO:0030100)
0.0 0.1 GO:0034284 response to hexose(GO:0009746) response to glucose(GO:0009749) response to monosaccharide(GO:0034284)
0.0 0.1 GO:0031060 regulation of histone methylation(GO:0031060)
0.0 0.8 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.0 0.4 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.4 GO:0034401 chromatin organization involved in regulation of transcription(GO:0034401)
0.0 0.2 GO:0071805 cellular potassium ion homeostasis(GO:0030007) potassium ion homeostasis(GO:0055075) cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 0.2 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.0 0.6 GO:0019740 nitrogen utilization(GO:0019740)
0.0 0.1 GO:0009187 cyclic nucleotide metabolic process(GO:0009187)
0.0 0.6 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.0 0.4 GO:0071459 protein localization to chromosome, centromeric region(GO:0071459)
0.0 0.6 GO:0006312 mitotic recombination(GO:0006312)
0.0 0.1 GO:0060988 lipid tube assembly(GO:0060988) protein-lipid complex assembly(GO:0065005) protein-lipid complex subunit organization(GO:0071825)
0.0 0.1 GO:0043687 C-terminal protein amino acid modification(GO:0018410) post-translational protein modification(GO:0043687)
0.0 0.4 GO:0045005 DNA-dependent DNA replication maintenance of fidelity(GO:0045005)
0.0 0.2 GO:0009435 NAD biosynthetic process(GO:0009435)
0.0 0.5 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.2 GO:0003400 regulation of COPII vesicle coating(GO:0003400) regulation of vesicle targeting, to, from or within Golgi(GO:0048209) regulation of ER to Golgi vesicle-mediated transport(GO:0060628) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.0 0.7 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.2 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 0.2 GO:0000338 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.0 0.1 GO:0032979 protein insertion into membrane from inner side(GO:0032978) protein insertion into mitochondrial membrane from inner side(GO:0032979)
0.0 0.1 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 0.1 GO:0006531 aspartate metabolic process(GO:0006531)
0.0 1.0 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 0.2 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.0 0.1 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.0 0.4 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.0 0.1 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.5 GO:0009247 glycolipid biosynthetic process(GO:0009247)
0.0 0.1 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 0.1 GO:0070941 eisosome assembly(GO:0070941)
0.0 0.0 GO:0000957 mitochondrial RNA catabolic process(GO:0000957)
0.0 0.1 GO:0000912 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin structure organization(GO:0031032) actomyosin contractile ring organization(GO:0044837)
0.0 0.1 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.1 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 9.0 GO:0000817 COMA complex(GO:0000817)
1.6 14.4 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
1.3 11.4 GO:0045263 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
1.1 4.5 GO:0097042 extrinsic component of fungal-type vacuolar membrane(GO:0097042)
1.1 5.4 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
1.1 1.1 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.9 3.8 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.8 2.4 GO:0005784 Sec61 translocon complex(GO:0005784)
0.8 2.3 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.7 2.1 GO:0005756 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
0.6 4.5 GO:0034657 GID complex(GO:0034657)
0.6 1.9 GO:0035649 Nrd1 complex(GO:0035649)
0.6 1.9 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.6 6.6 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.6 1.7 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.5 2.9 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.5 8.3 GO:0070469 respiratory chain(GO:0070469)
0.5 1.4 GO:0001400 mating projection base(GO:0001400)
0.5 0.9 GO:0030061 mitochondrial crista(GO:0030061)
0.4 0.4 GO:0000974 Prp19 complex(GO:0000974)
0.3 5.5 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.3 2.8 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.3 1.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.3 1.2 GO:0033309 SBF transcription complex(GO:0033309)
0.3 3.0 GO:0030677 ribonuclease P complex(GO:0030677)
0.3 1.3 GO:0005640 nuclear outer membrane(GO:0005640)
0.2 6.9 GO:0042763 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.2 5.8 GO:0005887 integral component of plasma membrane(GO:0005887)
0.2 0.7 GO:0032389 MutLalpha complex(GO:0032389)
0.2 1.4 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.2 10.7 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.2 0.7 GO:0046930 pore complex(GO:0046930)
0.2 0.6 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.2 0.4 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.2 2.9 GO:0033698 Rpd3L complex(GO:0033698)
0.2 1.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.2 8.5 GO:0031225 anchored component of membrane(GO:0031225)
0.2 0.7 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.2 0.8 GO:0032126 eisosome(GO:0032126)
0.2 6.0 GO:0005811 lipid particle(GO:0005811)
0.2 0.6 GO:0071819 DUBm complex(GO:0071819)
0.2 23.9 GO:0000323 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.2 2.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 4.2 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 0.6 GO:0070775 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.1 1.5 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.1 0.4 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.1 44.5 GO:0005886 plasma membrane(GO:0005886)
0.1 0.3 GO:0030874 nucleolar chromatin(GO:0030874)
0.1 0.4 GO:0033551 monopolin complex(GO:0033551)
0.1 0.5 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967) pyruvate dehydrogenase complex(GO:0045254)
0.1 0.5 GO:0016587 Isw1 complex(GO:0016587)
0.1 0.3 GO:0097002 mitochondrial inner boundary membrane(GO:0097002)
0.1 16.5 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 0.2 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.1 2.3 GO:0016592 mediator complex(GO:0016592)
0.1 0.8 GO:0031160 ascospore wall(GO:0005619) spore wall(GO:0031160)
0.1 0.4 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.1 46.2 GO:0005739 mitochondrion(GO:0005739)
0.1 0.2 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.1 1.9 GO:0019898 extrinsic component of membrane(GO:0019898)
0.1 0.1 GO:0070211 Snt2C complex(GO:0070211)
0.1 0.2 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.1 0.4 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.0 0.3 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.4 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.5 GO:0071012 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.0 0.3 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.2 GO:0031262 Ndc80 complex(GO:0031262)
0.0 0.2 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.5 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 0.2 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.1 GO:0031499 TRAMP complex(GO:0031499)
0.0 0.2 GO:0035267 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.0 GO:0070274 RES complex(GO:0070274)
0.0 0.1 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.7 22.6 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
4.2 16.7 GO:0004396 hexokinase activity(GO:0004396)
3.3 16.5 GO:0015295 solute:proton symporter activity(GO:0015295)
2.9 14.3 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
2.6 10.5 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
2.4 7.2 GO:0050136 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
2.2 8.7 GO:0005537 mannose binding(GO:0005537)
2.1 6.3 GO:0016208 AMP binding(GO:0016208)
2.0 6.1 GO:0016406 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
1.9 5.7 GO:0004629 phospholipase C activity(GO:0004629)
1.6 4.7 GO:0016289 CoA hydrolase activity(GO:0016289)
1.4 11.4 GO:0016679 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
1.4 4.1 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
1.3 4.0 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
1.3 3.9 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
1.3 5.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
1.3 3.8 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
1.2 13.5 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
1.2 6.1 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
1.2 5.8 GO:0050308 sugar-phosphatase activity(GO:0050308)
1.1 12.2 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
1.0 10.5 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
1.0 7.1 GO:0016833 oxo-acid-lyase activity(GO:0016833)
1.0 6.0 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.8 4.2 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.7 2.2 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.6 1.9 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.6 2.5 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.6 1.2 GO:0004364 glutathione transferase activity(GO:0004364)
0.6 2.9 GO:0004026 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.6 7.7 GO:0015578 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.5 4.2 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.5 2.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.5 3.1 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.5 4.6 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.5 2.0 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.5 7.6 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.4 7.6 GO:0008483 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.4 0.4 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.4 5.7 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.4 2.1 GO:0008198 ferrous iron binding(GO:0008198)
0.4 1.2 GO:0048038 quinone binding(GO:0048038)
0.4 1.2 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.4 3.2 GO:0015293 symporter activity(GO:0015293)
0.4 0.4 GO:0015151 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.4 1.5 GO:0008169 C-methyltransferase activity(GO:0008169)
0.4 2.3 GO:0000400 four-way junction DNA binding(GO:0000400)
0.4 2.6 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.3 1.4 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
0.3 3.4 GO:0001083 transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083)
0.3 2.9 GO:0010181 FMN binding(GO:0010181)
0.3 1.0 GO:0004555 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.3 5.0 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.3 2.5 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.3 1.2 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.3 3.0 GO:0004526 ribonuclease P activity(GO:0004526)
0.3 1.7 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.3 2.0 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.3 7.3 GO:0061733 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.3 3.8 GO:0004872 receptor activity(GO:0004872) molecular transducer activity(GO:0060089)
0.3 0.8 GO:0033592 RNA strand annealing activity(GO:0033592) annealing activity(GO:0097617)
0.3 1.3 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)
0.3 1.0 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.2 2.0 GO:0017136 NAD-dependent histone deacetylase activity(GO:0017136) NAD-dependent protein deacetylase activity(GO:0034979)
0.2 5.6 GO:0019901 protein kinase binding(GO:0019901)
0.2 3.2 GO:0016209 antioxidant activity(GO:0016209)
0.2 0.7 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.2 0.7 GO:0005253 anion channel activity(GO:0005253) voltage-gated anion channel activity(GO:0008308) porin activity(GO:0015288) wide pore channel activity(GO:0022829)
0.2 0.6 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.2 0.6 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.2 1.0 GO:0019212 protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
0.2 1.4 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
0.2 0.6 GO:0004866 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
0.2 6.1 GO:0008237 metallopeptidase activity(GO:0008237)
0.2 1.9 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 1.5 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.2 0.2 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 0.2 GO:0090482 vitamin transmembrane transporter activity(GO:0090482)
0.2 8.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.2 1.6 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.2 3.5 GO:0016836 hydro-lyase activity(GO:0016836)
0.2 4.1 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.2 1.9 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.2 0.6 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.2 1.1 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.2 0.3 GO:0000156 phosphorelay response regulator activity(GO:0000156)
0.2 0.8 GO:0016530 metallochaperone activity(GO:0016530)
0.2 0.6 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
0.1 1.6 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.1 0.4 GO:0004457 lactate dehydrogenase activity(GO:0004457) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
0.1 0.7 GO:0004559 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.1 1.3 GO:0000149 SNARE binding(GO:0000149)
0.1 0.9 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.1 2.5 GO:0005342 organic acid transmembrane transporter activity(GO:0005342)
0.1 0.4 GO:0070336 flap-structured DNA binding(GO:0070336)
0.1 0.4 GO:0015385 sodium:proton antiporter activity(GO:0015385)
0.1 0.7 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 1.6 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.1 2.7 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 0.6 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.1 0.4 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.1 0.2 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 0.3 GO:0016417 S-acyltransferase activity(GO:0016417)
0.1 2.2 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 0.3 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.1 0.5 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.1 1.4 GO:0046873 metal ion transmembrane transporter activity(GO:0046873)
0.1 0.3 GO:0031072 heat shock protein binding(GO:0031072)
0.1 1.2 GO:0020037 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.1 1.1 GO:0045182 translation regulator activity(GO:0045182)
0.1 3.5 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.1 1.1 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.1 0.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.3 GO:0019789 SUMO transferase activity(GO:0019789)
0.1 0.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 0.2 GO:0001156 transcription factor activity, core RNA polymerase III binding(GO:0000995) RNA polymerase III transcription factor binding(GO:0001025) TFIIIB-type transcription factor activity(GO:0001026) TFIIIC-class transcription factor binding(GO:0001156)
0.1 2.0 GO:0004871 signal transducer activity(GO:0004871)
0.1 5.6 GO:0051082 unfolded protein binding(GO:0051082)
0.1 0.7 GO:0030983 mismatched DNA binding(GO:0030983)
0.1 0.2 GO:0000150 recombinase activity(GO:0000150)
0.1 0.4 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.1 0.7 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.1 0.6 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.1 1.1 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.1 0.1 GO:0001091 RNA polymerase II basal transcription factor binding(GO:0001091)
0.1 0.2 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 0.4 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 1.3 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.1 0.2 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 0.3 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.1 0.4 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 0.8 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.0 0.2 GO:0050253 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.0 0.3 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.6 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.4 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 0.2 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.1 GO:0030332 cyclin binding(GO:0030332)
0.0 0.2 GO:0008144 drug binding(GO:0008144)
0.0 0.2 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.2 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.0 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 1.2 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 0.1 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.0 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.0 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 PID NOTCH PATHWAY Notch signaling pathway
0.9 1.7 PID IL4 2PATHWAY IL4-mediated signaling events
0.8 2.5 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.8 3.0 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.6 1.8 PID FOXO PATHWAY FoxO family signaling
0.5 1.5 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.4 0.4 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.4 1.8 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.3 2.3 PID FANCONI PATHWAY Fanconi anemia pathway
0.2 0.5 PID CMYB PATHWAY C-MYB transcription factor network
0.1 135.6 PID IFNG PATHWAY IFN-gamma pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.0 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.9 8.0 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.8 2.3 REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT Genes involved in The citric acid (TCA) cycle and respiratory electron transport
0.8 1.5 REACTOME TRIF MEDIATED TLR3 SIGNALING Genes involved in TRIF mediated TLR3 signaling
0.7 1.5 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.6 7.8 REACTOME DNA REPAIR Genes involved in DNA Repair
0.6 1.3 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.6 1.9 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.4 0.4 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.4 3.3 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 0.4 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 0.3 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.1 0.3 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 135.6 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 0.2 REACTOME INNATE IMMUNE SYSTEM Genes involved in Innate Immune System
0.0 0.2 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.1 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.0 0.2 REACTOME MEIOSIS Genes involved in Meiosis