Results for PHO4
Z-value: 1.70
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Transcription factors associated with PHO4
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
PHO4
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S000001930 | Basic helix-loop-helix (bHLH) transcription factor of the myc-family |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YOR348C Show fit | 27.71 |
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells |
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| YPL250C Show fit | 21.53 |
Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate |
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| YPL223C Show fit | 18.54 |
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway |
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| YCL040W Show fit | 12.54 |
Glucokinase, catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources |
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| YCL042W Show fit | 12.06 |
Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm |
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| YBR296C Show fit | 11.56 |
Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p |
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| YJR146W Show fit | 10.48 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2 |
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| YMR194C-B Show fit | 10.36 |
Putative protein of unknown function |
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| YJL133C-A Show fit | 10.12 |
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
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| YMR081C Show fit | 9.22 |
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant |
Network of associatons between targets according to the STRING database.
First level regulatory network of PHO4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.1 | 28.4 | GO:0015804 | neutral amino acid transport(GO:0015804) |
| 1.0 | 23.5 | GO:0000422 | mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726) |
| 4.4 | 17.5 | GO:0046323 | glucose import(GO:0046323) |
| 0.6 | 17.1 | GO:0098656 | anion transmembrane transport(GO:0098656) |
| 1.6 | 16.4 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 1.0 | 13.9 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 3.5 | 10.5 | GO:0042843 | D-xylose catabolic process(GO:0042843) |
| 0.7 | 10.4 | GO:0034085 | establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087) |
| 3.3 | 10.0 | GO:0015888 | thiamine transport(GO:0015888) |
| 1.1 | 9.8 | GO:0006097 | glyoxylate cycle(GO:0006097) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 46.2 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 44.5 | GO:0005886 | plasma membrane(GO:0005886) |
| 0.2 | 23.9 | GO:0000323 | storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324) |
| 0.1 | 16.5 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 1.6 | 14.4 | GO:0045275 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 1.3 | 11.4 | GO:0045263 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263) |
| 0.2 | 10.7 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 2.3 | 9.0 | GO:0000817 | COMA complex(GO:0000817) |
| 0.2 | 8.5 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.5 | 8.3 | GO:0070469 | respiratory chain(GO:0070469) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.7 | 22.6 | GO:0015193 | L-proline transmembrane transporter activity(GO:0015193) |
| 4.2 | 16.7 | GO:0004396 | hexokinase activity(GO:0004396) |
| 3.3 | 16.5 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 2.9 | 14.3 | GO:0005315 | inorganic phosphate transmembrane transporter activity(GO:0005315) |
| 1.2 | 13.5 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 1.1 | 12.2 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 1.4 | 11.4 | GO:0016679 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 2.6 | 10.5 | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity(GO:0004032) |
| 1.0 | 10.5 | GO:0015205 | nucleobase transmembrane transporter activity(GO:0015205) |
| 2.2 | 8.7 | GO:0005537 | mannose binding(GO:0005537) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 135.6 | PID IFNG PATHWAY | IFN-gamma pathway |
| 1.1 | 3.3 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.8 | 3.0 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.8 | 2.5 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.3 | 2.3 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.6 | 1.8 | PID FOXO PATHWAY | FoxO family signaling |
| 0.4 | 1.8 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.9 | 1.7 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.5 | 1.5 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.2 | 0.5 | PID CMYB PATHWAY | C-MYB transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 135.6 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.9 | 8.0 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.6 | 7.8 | REACTOME DNA REPAIR | Genes involved in DNA Repair |
| 0.4 | 3.3 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 1.0 | 3.0 | REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE | Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle |
| 0.8 | 2.3 | REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT | Genes involved in The citric acid (TCA) cycle and respiratory electron transport |
| 0.6 | 1.9 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.8 | 1.5 | REACTOME TRIF MEDIATED TLR3 SIGNALING | Genes involved in TRIF mediated TLR3 signaling |
| 0.7 | 1.5 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.6 | 1.3 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |