Results for PHD1
Z-value: 0.98
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Transcription factors associated with PHD1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
PHD1
|
S000001526 | Transcriptional activator that enhances pseudohyphal growth |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YMR017W Show fit | 20.40 |
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog |
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| YAR053W Show fit | 12.54 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
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| YFL051C Show fit | 11.61 |
Putative protein of unknown function; YFL051C is not an essential gene |
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| YAL062W Show fit | 10.02 |
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources |
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| YDR536W Show fit | 9.70 |
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock |
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| YOR100C Show fit | 9.54 |
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation |
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| YAR060C Show fit | 9.23 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
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| YKL217W Show fit | 9.16 |
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose |
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| YDL210W Show fit | 7.95 |
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane |
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| YMR206W Show fit | 7.27 |
Putative protein of unknown function; YMR206W is not an essential gene |
Network of associatons between targets according to the STRING database.
First level regulatory network of PHD1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 19.4 | GO:0031321 | ascospore-type prospore assembly(GO:0031321) |
| 2.0 | 11.8 | GO:0000128 | flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501) |
| 2.8 | 11.4 | GO:0006848 | pyruvate transport(GO:0006848) |
| 0.2 | 9.6 | GO:0009060 | aerobic respiration(GO:0009060) |
| 1.9 | 9.5 | GO:0015793 | glycerol transport(GO:0015793) |
| 3.0 | 8.9 | GO:0019676 | ammonia assimilation cycle(GO:0019676) |
| 0.5 | 8.5 | GO:0009228 | thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724) |
| 2.0 | 8.0 | GO:0015847 | putrescine transport(GO:0015847) |
| 1.4 | 5.8 | GO:0006075 | (1->3)-beta-D-glucan biosynthetic process(GO:0006075) |
| 0.6 | 5.8 | GO:0006097 | glyoxylate cycle(GO:0006097) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 32.1 | GO:0005886 | plasma membrane(GO:0005886) |
| 0.2 | 25.0 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.8 | 20.2 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.1 | 12.0 | GO:0000329 | fungal-type vacuole membrane(GO:0000329) lytic vacuole membrane(GO:0098852) |
| 0.3 | 8.3 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.1 | 6.9 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.5 | 6.4 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 6.2 | GO:0005740 | mitochondrial envelope(GO:0005740) |
| 1.5 | 5.8 | GO:0000148 | 1,3-beta-D-glucan synthase complex(GO:0000148) |
| 0.4 | 3.7 | GO:0045263 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.4 | 27.2 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 0.8 | 20.0 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 3.3 | 13.3 | GO:0005537 | mannose binding(GO:0005537) |
| 2.3 | 9.2 | GO:0016639 | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639) |
| 0.8 | 9.2 | GO:0022838 | substrate-specific channel activity(GO:0022838) |
| 0.1 | 8.0 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.4 | 7.3 | GO:0015297 | antiporter activity(GO:0015297) |
| 0.1 | 6.7 | GO:0001228 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 1.9 | 5.8 | GO:0003843 | 1,3-beta-D-glucan synthase activity(GO:0003843) |
| 1.7 | 5.2 | GO:0004092 | carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 151.0 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.6 | 1.9 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 1.1 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.3 | 1.0 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.2 | 0.8 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.2 | 0.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 0.5 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.2 | 0.5 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.2 | 0.3 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 0.3 | PID FOXO PATHWAY | FoxO family signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 148.4 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 1.6 | 4.7 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.2 | 0.5 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 0.5 | REACTOME PHOSPHORYLATION OF THE APC C | Genes involved in Phosphorylation of the APC/C |
| 0.1 | 0.5 | REACTOME TOLL RECEPTOR CASCADES | Genes involved in Toll Receptor Cascades |
| 0.1 | 0.4 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.1 | 0.4 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.1 | 0.4 | REACTOME BIOLOGICAL OXIDATIONS | Genes involved in Biological oxidations |
| 0.1 | 0.4 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.1 | 0.3 | REACTOME HEMOSTASIS | Genes involved in Hemostasis |