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Results for PDR3

Z-value: 0.49

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Transcription factors associated with PDR3

Gene Symbol Gene ID Gene Info
PDR3
S000000101 Transcriptional activator of the pleiotropic drug resistance network

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PDR3YBL005W-0.611.0e-03Click!

Activity profile of PDR3 motif

Sorted Z-values of PDR3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YFR055W 6.09
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YFR056C 5.42 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YOR153W 4.74
PDR5
Plasma membrane ATP-binding cassette (ABC) transporter, short-lived multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth
YER131W 4.64
RPS26B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YMR102C 4.54 Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
YGL157W 4.26 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YLR413W 4.12 Putative protein of unknown function; YLR413W is not an essential gene
YPL250W-A 4.08 Identified by fungal homology and RT-PCR
YJR094W-A 3.78
RPL43B
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YDR345C 3.62
HXT3
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YJL158C 3.21
CIS3
Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
YGL209W 3.17
MIG2
Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter
YNL178W 2.94
RPS3
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YDR279W 2.86
RNH202
Ribonuclease H2 subunit, required for RNase H2 activity
YKL096W-A 2.82
CWP2
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YDR044W 2.56
HEM13
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YOR315W 2.48
SFG1
Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
YDR502C 2.45
SAM2
S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YCL063W 2.33
VAC17
Protein involved in vacuole inheritance; acts as a vacuole-specific receptor for myosin Myo2p
YGR280C 2.32
PXR1
Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain
YLR333C 2.31
RPS25B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Ap and has similarity to rat S25 ribosomal protein
YPR119W 2.25
CLB2
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YOR050C 2.24 Hypothetical protein
YLR448W 2.15
RPL6B
Protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Ap and to rat L6 ribosomal protein; binds to 5.8S rRNA
YGR249W 2.03
MGA1
Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants
YDR002W 1.98
YRB1
Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1
YLR349W 1.96 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C
YLR348C 1.95
DIC1
Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix
YNL231C 1.90
PDR16
Phosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p, localizes to lipid particles and microsomes, controls levels of various lipids, may regulate lipid synthesis, homologous to Pdr17p
YPR148C 1.89 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YKR092C 1.88
SRP40
Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YDR278C 1.86 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YCL064C 1.82
CHA1
Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine
YOL124C 1.80
TRM11
Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
YPR157W 1.71 Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YER130C 1.70 Hypothetical protein
YOR369C 1.66
RPS12
Protein component of the small (40S) ribosomal subunit; has similarity to rat ribosomal protein S12
YBR048W 1.65
RPS11B
Protein component of the small (40S) ribosomal subunit; identical to Rps11Ap and has similarity to E. coli S17 and rat S11 ribosomal proteins
YML026C 1.65
RPS18B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Ap and has similarity to E. coli S13 and rat S18 ribosomal proteins
YJL011C 1.64
RPC17
RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex
YLR075W 1.59
RPL10
Protein component of the large (60S) ribosomal subunit, responsible for joining the 40S and 60S subunits; regulates translation initiation; has similarity to rat L10 ribosomal protein and to members of the QM gene family
YDR025W 1.59
RPS11A
Protein component of the small (40S) ribosomal subunit; identical to Rps11Bp and has similarity to E. coli S17 and rat S11 ribosomal proteins
YFR054C 1.51 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL216C 1.50 Protein of unknown function, similar to alpha-D-glucosidases; transcriptionally activated by both Pdr8p and Yrm1p, along with transporters and other genes involved in the pleiotropic drug resistance (PDR) phenomenon
YOR327C 1.49
SNC2
Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins
YOR163W 1.48
DDP1
Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; has high specificity for diadenosine hexa- and pentaphosphates; member of the MutT family of nucleotide hydrolases
YHR128W 1.46
FUR1
Uracil phosphoribosyltransferase, synthesizes UMP from uracil; involved in the pyrimidine salvage pathway
YER177W 1.45
BMH1
14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
YHR136C 1.42
SPL2
Protein with similarity to cyclin-dependent kinase inhibitors, overproduction suppresses a plc1 null mutation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YBR143C 1.40
SUP45
Polypeptide release factor involved in translation termination; mutant form acts as a recessive omnipotent suppressor
YCR004C 1.39
YCP4
Protein of unknown function, has sequence and structural similarity to flavodoxins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YIL056W 1.37
VHR1
Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations
YLL028W 1.36
TPO1
Polyamine transporter that recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane
YMR015C 1.34
ERG5
C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
YBR257W 1.34
POP4
Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; binds to the RPR1 RNA subunit in Rnase P
YGR052W 1.33
FMP48
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
YMR246W 1.33
FAA4
Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipids
YOL101C 1.33
IZH4
Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism
YBR084W 1.30
MIS1
Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
YML075C 1.29
HMG1
One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae
YJR043C 1.28
POL32
Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p
YDR033W 1.28
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YER124C 1.27
DSE1
Daughter cell-specific protein, may participate in pathways regulating cell wall metabolism; deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall
YGR214W 1.27
RPS0A
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YPR074C 1.26
TKL1
Transketolase, similar to Tkl2p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YBR256C 1.25
RIB5
Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway
YJL153C 1.25
INO1
Inositol 1-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
YKL218C 1.23
SRY1
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YKR075C 1.23 Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YLR314C 1.20
CDC3
Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YBR210W 1.18
ERV15
Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p
YDL022C-A 1.17 Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene DIA3; identified by fungal homology and RT-PCR
YPL062W 1.17 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation
YHR094C 1.16
HXT1
Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YNL289W 1.15
PCL1
Pho85 cyclin of the Pcl1,2-like subfamily, involved in entry into the mitotic cell cycle and regulation of morphogenesis, localizes to sites of polarized cell growth
YKL051W 1.15
SFK1
Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
YGR264C 1.14
MES1
Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs
YGR121W-A 1.12 Putative protein of unknown function
YLR301W 1.11 Protein of unknown function that interacts with Sec72p
YNR013C 1.11
PHO91
Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YGL179C 1.11
TOS3
Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YDL023C 1.08 Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
YKL165C 1.08
MCD4
Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes
YDR471W 1.06
RPL27B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Ap and has similarity to rat L27 ribosomal protein
YJL148W 1.06
RPA34
RNA polymerase I subunit A34.5
YOR314W 1.06 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR290C 1.06
HAS1
ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YGR265W 1.05 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase
YHR021C 1.05
RPS27B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Ap and has similarity to rat S27 ribosomal protein
YPL249C-A 1.04
RPL36B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Ap and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA
YHL028W 1.04
WSC4
ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3
YGR050C 1.04 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOL123W 1.03
HRP1
Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences
YLR367W 1.00
RPS22B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Ap and has similarity to E. coli S8 and rat S15a ribosomal proteins
YGR128C 0.99
UTP8
Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YDR041W 0.99
RSM10
Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
YMR290W-A 0.99 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YGR034W 0.98
RPL26B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Ap and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA
YJL200C 0.98
ACO2
Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
YBL085W 0.98
BOI1
Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
YPL112C 0.97
PEX25
Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p
YER137C 0.93 Putative protein of unknown function
YMR083W 0.93
ADH3
Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YLR312W-A 0.92
MRPL15
Mitochondrial ribosomal protein of the large subunit
YKL180W 0.92
RPL17A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Bp and has similarity to E. coli L22 and rat L17 ribosomal proteins; copurifies with the Dam1 complex (aka DASH complex)
YGL031C 0.92
RPL24A
Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YDL022W 0.91
GPD1
NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p
YIL011W 0.90
TIR3
Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth
YMR307W 0.90
GAS1
Beta-1,3-glucanosyltransferase, required for cell wall assembly; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor
YHR068W 0.90
DYS1
Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric
YIL133C 0.90
RPL16A
N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
YDL143W 0.88
CCT4
Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YDR072C 0.88
IPT1
Inositolphosphotransferase 1, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), which is the most abundant sphingolipid in cells, mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media
YKR074W 0.87
AIM29
Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YGR251W 0.87 Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YLR042C 0.87 Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene
YOR313C 0.86
SPS4
Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage
YER074W 0.86
RPS24A
Protein component of the small (40S) ribosomal subunit; identical to Rps24Bp and has similarity to rat S24 ribosomal protein
YPL177C 0.86
CUP9
Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription
YOL012C 0.85
HTZ1
Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
YCR102W-A 0.85 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL137C 0.85
GIP3
Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments
YOR008C-A 0.84 Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres
YBR181C 0.83
RPS6B
Protein component of the small (40S) ribosomal subunit; identical to Rps6Ap and has similarity to rat S6 ribosomal protein
YMR208W 0.83
ERG12
Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
YJR070C 0.82
LIA1
Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyses hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning
YHR149C 0.82
SKG6
Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
YLR150W 0.82
STM1
Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations
YHR081W 0.81
LRP1
Substrate-specific nuclear cofactor for exosome activity in the processing of stable RNAs; required for telomere length maintenance; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination
YMR033W 0.81
ARP9
Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
YGL030W 0.80
RPL30
Protein component of the large (60S) ribosomal subunit, has similarity to rat L30 ribosomal protein; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript
YJR071W 0.80 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR040C 0.80
ENA1
P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance
YJL162C 0.79
JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YDR098C 0.79
GRX3
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YGR118W 0.78
RPS23A
Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; nearly identical to Rps23Bp and similar to E. coli S12 and rat S23 ribosomal proteins; deletion of both RPS23A and RPS23B is lethal
YIL076W 0.78
SEC28
Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth
YDR385W 0.77
EFT2
Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
YHR010W 0.77
RPL27A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Bp and has similarity to rat L27 ribosomal protein
YHR013C 0.77
ARD1
Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
YDR346C 0.76
SVF1
Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis
YDR086C 0.76
SSS1
Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p
YOL011W 0.76
PLB3
Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro
YMR194C-A 0.76 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBL006C 0.76
LDB7
Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
YOR273C 0.75
TPO4
Polyamine transport protein, recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily
YKL008C 0.72
LAC1
Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p
YMR011W 0.72
HXT2
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YOR108W 0.71
LEU9
Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant
YGR108W 0.71
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YMR108W 0.71
ILV2
Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control
YER036C 0.70
ARB1
ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p
YHR137W 0.70
ARO9
Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism
YHR071C-A 0.70 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF ERG7/YHR072W
YKL052C 0.70
ASK1
Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases
YGR051C 0.69 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene
YNL028W 0.69 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YEL020C-B 0.68 Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene YEL020W-A; identified by fungal homology and RT-PCR
YGR060W 0.68
ERG25
C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol
YDR500C 0.68
RPL37B
Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Ap and to rat L37 ribosomal protein
YKR093W 0.68
PTR2
Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
YGR242W 0.68 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
YDR215C 0.67 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein
YER012W 0.67
PRE1
Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
YIR033W 0.67
MGA2
ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting
YOL015W 0.66
IRC10
Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci
YHR029C 0.66
YHI9
Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production
YLR325C 0.66
RPL38
Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein
YDR418W 0.66
RPL12B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins
YMR251W-A 0.66
HOR7
Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor
YPL256C 0.66
CLN2
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YDR091C 0.66
RLI1
Essential iron-sulfur protein required for ribosome biogenesis and translation initiation; facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit; predicted ABC family ATPase
YKL182W 0.66
FAS1
Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
YER120W 0.66
SCS2
Integral ER membrane protein that regulates phospholipid metabolism via an interaction with the FFAT motif of Opi1p, also involved in telomeric silencing, disruption causes inositol auxotrophy above 34 degrees C, VAP homolog
YOR332W 0.65
VMA4
Subunit E of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
YGR138C 0.65
TPO2
Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
YLR099W-A 0.65 Putative protein of unknown function
YPL178W 0.65
CBC2
Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif
YNL160W 0.64
YGP1
Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p
YDR074W 0.64
TPS2
Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway
YBR249C 0.64
ARO4
3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan
YPR010C 0.64
RPA135
RNA polymerase I subunit A135
YPL265W 0.64
DIP5
Dicarboxylic amino acid permease, mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly
YIL163C 0.63 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL198W 0.63
PHO90
Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YMR082C 0.63 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL029W 0.62
CGR1
Protein involved in nucleolar integrity and processing of the pre-rRNA for the 60S ribosome subunit; transcript is induced in response to cytotoxic stress but not genotoxic stress
YEL027W 0.62
CUP5
Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis
YBR138C 0.62 Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene
YGR017W 0.61 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
YER056C-A 0.61
RPL34A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Bp and has similarity to rat L34 ribosomal protein
YBR248C 0.61
HIS7
Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth and sixth steps of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor
YCR104W 0.60
PAU3
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YGR253C 0.60
PUP2
Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
YLR441C 0.60
RPS1A
Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Bp and has similarity to rat S3a ribosomal protein
YNL175C 0.60
NOP13
Protein of unknown function, localizes to the nucleolus and nucleoplasm; contains an RNA recognition motif (RRM) and has similarity to Nop12p, which is required for processing of pre-18S rRNA
YML043C 0.59
RRN11
Protein required for rDNA transcription by RNA polymerase I, component of the core factor (CF) of rDNA transcription factor, which also contains Rrn6p and Rrn7p
YER119C-A 0.59 Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene SCS2
YLR447C 0.59
VMA6
Subunit d of the five-subunit V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found in the endomembrane system; stabilizes VO subunits; required for V1 domain assembly on the vacuolar membrane
YLL044W 0.59 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant

Network of associatons between targets according to the STRING database.

First level regulatory network of PDR3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.6 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
1.4 5.8 GO:0046898 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
0.9 3.4 GO:1900436 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
0.8 3.1 GO:0000296 spermine transport(GO:0000296)
0.8 0.8 GO:0045901 positive regulation of translational elongation(GO:0045901)
0.7 12.1 GO:0051029 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
0.7 2.6 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
0.6 1.9 GO:0006567 threonine catabolic process(GO:0006567)
0.6 4.3 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.6 2.3 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211) negative regulation of telomere maintenance via telomere lengthening(GO:1904357)
0.6 2.3 GO:0035337 fatty-acyl-CoA metabolic process(GO:0035337)
0.5 2.1 GO:0019287 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490)
0.5 1.4 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.4 1.7 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.4 1.1 GO:0006798 polyphosphate catabolic process(GO:0006798)
0.4 1.5 GO:0043097 pyrimidine ribonucleotide salvage(GO:0010138) pyrimidine nucleotide salvage(GO:0032262) pyrimidine nucleoside salvage(GO:0043097) UMP salvage(GO:0044206)
0.4 1.1 GO:0033559 unsaturated fatty acid biosynthetic process(GO:0006636) unsaturated fatty acid metabolic process(GO:0033559)
0.3 2.4 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
0.3 2.4 GO:0046501 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.3 3.8 GO:0006817 phosphate ion transport(GO:0006817)
0.3 4.6 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.3 1.2 GO:0015867 ATP transport(GO:0015867)
0.3 2.6 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.3 0.3 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.3 2.9 GO:0006547 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.3 1.4 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.3 0.8 GO:2000879 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
0.3 0.8 GO:0043066 negative regulation of apoptotic process(GO:0043066) negative regulation of programmed cell death(GO:0043069) negative regulation of cell death(GO:0060548)
0.3 0.8 GO:0043484 regulation of RNA splicing(GO:0043484) regulation of mRNA splicing, via spliceosome(GO:0048024)
0.3 3.7 GO:0006415 translational termination(GO:0006415)
0.3 0.8 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.2 2.7 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
0.2 1.2 GO:0009098 leucine biosynthetic process(GO:0009098)
0.2 0.9 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.2 0.7 GO:0032365 intracellular lipid transport(GO:0032365) negative regulation of transcription factor import into nucleus(GO:0042992)
0.2 27.0 GO:0002181 cytoplasmic translation(GO:0002181)
0.2 1.1 GO:0046417 chorismate metabolic process(GO:0046417)
0.2 1.8 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.2 1.1 GO:0009099 valine biosynthetic process(GO:0009099)
0.2 0.5 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
0.2 1.3 GO:0006771 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.2 2.3 GO:0007120 axial cellular bud site selection(GO:0007120)
0.2 0.7 GO:0006797 polyphosphate metabolic process(GO:0006797)
0.2 1.9 GO:0000921 septin ring assembly(GO:0000921)
0.2 0.9 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.2 2.6 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.2 0.9 GO:0006814 sodium ion transport(GO:0006814)
0.1 1.3 GO:0031070 intronic snoRNA processing(GO:0031070) intronic box C/D snoRNA processing(GO:0034965)
0.1 2.3 GO:0000011 vacuole inheritance(GO:0000011)
0.1 3.5 GO:0006885 regulation of pH(GO:0006885)
0.1 0.4 GO:0043171 peptide catabolic process(GO:0043171)
0.1 1.2 GO:0006882 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.1 0.3 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.1 0.4 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
0.1 4.5 GO:0006694 steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126)
0.1 0.9 GO:0006672 ceramide metabolic process(GO:0006672) ceramide biosynthetic process(GO:0046513)
0.1 1.8 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 0.4 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.1 1.0 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.1 2.3 GO:0030488 tRNA methylation(GO:0030488)
0.1 0.4 GO:0008272 sulfate transport(GO:0008272)
0.1 0.7 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.1 0.5 GO:0015883 FAD transport(GO:0015883)
0.1 0.6 GO:0006021 inositol biosynthetic process(GO:0006021)
0.1 1.0 GO:0034476 U5 snRNA 3'-end processing(GO:0034476) nuclear polyadenylation-dependent CUT catabolic process(GO:0071039)
0.1 0.5 GO:0042938 dipeptide transport(GO:0042938)
0.1 0.6 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.1 1.1 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.1 0.6 GO:0000162 tryptophan biosynthetic process(GO:0000162) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
0.1 0.8 GO:0006901 vesicle coating(GO:0006901)
0.1 0.4 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.1 2.7 GO:0006334 nucleosome assembly(GO:0006334)
0.1 0.9 GO:0016559 peroxisome fission(GO:0016559)
0.1 0.2 GO:0031564 transcriptional attenuation(GO:0031555) transcription antitermination(GO:0031564)
0.1 0.4 GO:0030497 fatty acid elongation(GO:0030497)
0.1 1.0 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.1 1.8 GO:0031498 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.1 0.2 GO:0010674 negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010674)
0.1 0.2 GO:0046677 response to antibiotic(GO:0046677)
0.1 0.5 GO:0035392 maintenance of chromatin silencing(GO:0006344) maintenance of chromatin silencing at telomere(GO:0035392) protein targeting to nuclear inner membrane(GO:0036228)
0.1 0.4 GO:1903530 regulation of exocytosis(GO:0017157) regulation of secretion(GO:0051046) regulation of formin-nucleated actin cable assembly(GO:0090337) positive regulation of formin-nucleated actin cable assembly(GO:0090338) regulation of secretion by cell(GO:1903530)
0.1 0.3 GO:0019673 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
0.1 1.2 GO:0006098 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.1 0.5 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509) amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
0.1 2.1 GO:0006893 Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.1 1.3 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.1 0.3 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.1 0.3 GO:0001109 promoter clearance during DNA-templated transcription(GO:0001109) promoter clearance from RNA polymerase II promoter(GO:0001111)
0.1 0.4 GO:0000707 meiotic DNA recombinase assembly(GO:0000707) DNA recombinase assembly(GO:0000730)
0.1 0.5 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.1 0.3 GO:0006857 oligopeptide transport(GO:0006857)
0.1 0.4 GO:0007030 Golgi organization(GO:0007030)
0.1 5.1 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.1 0.2 GO:0010695 regulation of spindle pole body separation(GO:0010695)
0.1 0.6 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.1 0.2 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.1 0.3 GO:0035376 sterol import(GO:0035376)
0.1 1.3 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.1 0.3 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) negative regulation of actin nucleation(GO:0051126)
0.1 1.1 GO:0007009 plasma membrane organization(GO:0007009)
0.1 2.7 GO:0006606 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) nuclear import(GO:0051170) single-organism nuclear import(GO:1902593)
0.1 0.2 GO:0036498 mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response(GO:0030969) IRE1-mediated unfolded protein response(GO:0036498) mRNA splicing, via endonucleolytic cleavage and ligation(GO:0070054)
0.1 0.4 GO:0042823 pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823) aldehyde biosynthetic process(GO:0046184)
0.1 0.2 GO:0048279 vesicle fusion with endoplasmic reticulum(GO:0048279)
0.1 0.3 GO:0007535 donor selection(GO:0007535)
0.1 0.4 GO:0019935 cAMP-mediated signaling(GO:0019933) cyclic-nucleotide-mediated signaling(GO:0019935)
0.1 0.3 GO:0060277 obsolete negative regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0060277)
0.1 1.1 GO:0006379 mRNA cleavage(GO:0006379)
0.1 0.6 GO:0055070 cellular copper ion homeostasis(GO:0006878) copper ion homeostasis(GO:0055070)
0.1 0.1 GO:0034198 cellular response to amino acid starvation(GO:0034198)
0.1 0.3 GO:0018279 peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279)
0.1 0.2 GO:0015809 arginine transport(GO:0015809)
0.1 1.0 GO:0045047 protein targeting to ER(GO:0045047)
0.1 0.2 GO:0033241 regulation of cellular amine catabolic process(GO:0033241)
0.1 1.0 GO:0006144 purine nucleobase metabolic process(GO:0006144)
0.1 0.1 GO:0000957 mitochondrial RNA catabolic process(GO:0000957)
0.1 1.1 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.1 0.2 GO:0015680 intracellular copper ion transport(GO:0015680)
0.1 0.5 GO:0016233 telomere capping(GO:0016233)
0.1 0.4 GO:0005992 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.1 0.2 GO:0009097 aspartate metabolic process(GO:0006531) isoleucine biosynthetic process(GO:0009097)
0.1 0.4 GO:0001402 signal transduction involved in filamentous growth(GO:0001402)
0.1 0.3 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.1 0.4 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.1 0.2 GO:1901977 regulation of cell cycle checkpoint(GO:1901976) negative regulation of cell cycle checkpoint(GO:1901977) regulation of DNA damage checkpoint(GO:2000001) negative regulation of DNA damage checkpoint(GO:2000002) negative regulation of response to DNA damage stimulus(GO:2001021)
0.1 0.6 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 0.3 GO:0010455 positive regulation of cell fate commitment(GO:0010455) positive regulation of mating type switching(GO:0031496) positive regulation of cell differentiation(GO:0045597)
0.0 0.8 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.2 GO:0050000 telomere localization(GO:0034397) meiotic telomere clustering(GO:0045141) chromosome localization(GO:0050000) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.0 0.2 GO:0051597 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
0.0 1.4 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 0.3 GO:0030011 maintenance of cell polarity(GO:0030011)
0.0 0.1 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.0 0.2 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 0.2 GO:0019358 nicotinate nucleotide biosynthetic process(GO:0019357) nicotinate nucleotide salvage(GO:0019358) pyridine nucleotide salvage(GO:0019365) nicotinate nucleotide metabolic process(GO:0046497)
0.0 0.2 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.0 0.2 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.0 1.1 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.3 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 0.9 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.2 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.3 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0 0.1 GO:0044818 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972) mitotic G2/M transition checkpoint(GO:0044818) negative regulation of cell cycle G2/M phase transition(GO:1902750)
0.0 0.6 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 1.3 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.2 GO:0051016 regulation of actin filament depolymerization(GO:0030834) negative regulation of actin filament depolymerization(GO:0030835) barbed-end actin filament capping(GO:0051016) actin filament capping(GO:0051693)
0.0 0.2 GO:0072337 modified amino acid transport(GO:0072337)
0.0 0.3 GO:0000376 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.0 0.2 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.3 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.4 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.0 0.1 GO:0006517 protein deglycosylation(GO:0006517)
0.0 0.1 GO:0018904 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.0 0.0 GO:0070827 chromatin maintenance(GO:0070827)
0.0 0.1 GO:0016093 polyprenol metabolic process(GO:0016093) polyprenol biosynthetic process(GO:0016094) dolichol metabolic process(GO:0019348) dolichol biosynthetic process(GO:0019408)
0.0 0.7 GO:0071428 rRNA-containing ribonucleoprotein complex export from nucleus(GO:0071428)
0.0 0.1 GO:0045744 termination of signal transduction(GO:0023021) termination of G-protein coupled receptor signaling pathway(GO:0038032) negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 0.1 GO:0009394 pyrimidine deoxyribonucleotide metabolic process(GO:0009219) pyrimidine deoxyribonucleotide biosynthetic process(GO:0009221) 2'-deoxyribonucleotide biosynthetic process(GO:0009265) 2'-deoxyribonucleotide metabolic process(GO:0009394) deoxyribose phosphate biosynthetic process(GO:0046385)
0.0 1.3 GO:0006413 translational initiation(GO:0006413)
0.0 0.1 GO:0046337 phosphatidylethanolamine biosynthetic process(GO:0006646) phosphatidylethanolamine metabolic process(GO:0046337)
0.0 0.6 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.0 0.1 GO:0033875 coenzyme A metabolic process(GO:0015936) nucleoside bisphosphate metabolic process(GO:0033865) ribonucleoside bisphosphate metabolic process(GO:0033875) purine nucleoside bisphosphate metabolic process(GO:0034032)
0.0 2.8 GO:0006364 rRNA processing(GO:0006364)
0.0 0.2 GO:0009395 phospholipid catabolic process(GO:0009395)
0.0 0.3 GO:0006037 cell wall chitin metabolic process(GO:0006037)
0.0 0.1 GO:0016074 snoRNA metabolic process(GO:0016074)
0.0 0.3 GO:0034620 endoplasmic reticulum unfolded protein response(GO:0030968) cellular response to unfolded protein(GO:0034620)
0.0 0.4 GO:0009304 tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0 0.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.1 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.1 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143)
0.0 0.2 GO:0051598 meiotic cell cycle checkpoint(GO:0033313) meiotic recombination checkpoint(GO:0051598)
0.0 0.1 GO:0043902 positive regulation of multi-organism process(GO:0043902)
0.0 0.1 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.0 0.1 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.2 GO:0009435 NAD biosynthetic process(GO:0009435)
0.0 0.2 GO:0006768 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.0 0.1 GO:0007119 budding cell isotropic bud growth(GO:0007119)
0.0 0.3 GO:0051668 localization within membrane(GO:0051668)
0.0 0.1 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.3 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889) regulation of vacuole organization(GO:0044088)
0.0 0.1 GO:0045859 regulation of protein kinase activity(GO:0045859)
0.0 0.0 GO:0042542 response to hydrogen peroxide(GO:0042542)
0.0 0.0 GO:0006378 mRNA polyadenylation(GO:0006378)
0.0 0.3 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.0 1.2 GO:0030036 actin cytoskeleton organization(GO:0030036)
0.0 0.1 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0006596 polyamine biosynthetic process(GO:0006596)
0.0 0.1 GO:0008298 intracellular mRNA localization(GO:0008298)
0.0 0.1 GO:0070651 nonfunctional rRNA decay(GO:0070651)
0.0 0.1 GO:0034249 negative regulation of translation(GO:0017148) negative regulation of cellular amide metabolic process(GO:0034249)
0.0 0.3 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.1 GO:0048278 vesicle docking(GO:0048278)
0.0 0.1 GO:0009371 positive regulation of transcription from RNA polymerase II promoter by pheromones(GO:0007329) positive regulation of transcription by pheromones(GO:0009371)
0.0 0.0 GO:0034402 recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex(GO:0034402)
0.0 0.1 GO:0035437 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.0 0.2 GO:0032508 DNA duplex unwinding(GO:0032508)
0.0 0.0 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.4 GO:0051169 nucleocytoplasmic transport(GO:0006913) nuclear transport(GO:0051169)
0.0 0.1 GO:0009303 rRNA transcription(GO:0009303)
0.0 0.0 GO:0098609 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.0 0.1 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.1 GO:0051666 actin cortical patch localization(GO:0051666)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.0 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.4 1.3 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.4 25.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.4 1.1 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
0.3 0.9 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.3 1.2 GO:0032160 septin filament array(GO:0032160)
0.3 1.8 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.3 0.9 GO:0030428 cell septum(GO:0030428)
0.3 0.8 GO:0005784 Sec61 translocon complex(GO:0005784)
0.3 22.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.3 0.8 GO:0031415 NatA complex(GO:0031415)
0.2 0.7 GO:0070545 PeBoW complex(GO:0070545)
0.2 0.2 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.2 0.9 GO:0070860 RNA polymerase I core factor complex(GO:0070860)
0.2 1.7 GO:0033101 cellular bud membrane(GO:0033101)
0.2 1.4 GO:0034455 t-UTP complex(GO:0034455)
0.2 2.4 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.2 0.7 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.2 0.5 GO:0070985 TFIIK complex(GO:0070985)
0.2 1.6 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.2 2.3 GO:0000786 nucleosome(GO:0000786)
0.2 0.6 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.2 0.9 GO:0048500 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.1 1.0 GO:0072686 mitotic spindle(GO:0072686)
0.1 1.3 GO:0030681 nucleolar ribonuclease P complex(GO:0005655) multimeric ribonuclease P complex(GO:0030681)
0.1 0.6 GO:0033179 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.1 2.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 0.7 GO:0030689 Noc complex(GO:0030689)
0.1 1.0 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 0.5 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 0.6 GO:0034518 RNA cap binding complex(GO:0034518)
0.1 0.9 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.1 1.0 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 0.1 GO:0032156 septin cytoskeleton(GO:0032156)
0.1 0.5 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 2.0 GO:0016586 RSC complex(GO:0016586)
0.1 0.3 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1 4.1 GO:0005811 lipid particle(GO:0005811)
0.1 1.4 GO:0034399 nuclear periphery(GO:0034399)
0.1 0.3 GO:0044697 HICS complex(GO:0044697)
0.1 0.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 1.1 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 0.5 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.1 0.7 GO:0000346 transcription export complex(GO:0000346)
0.1 1.0 GO:0032161 cellular bud neck septin structure(GO:0000399) cleavage apparatus septin structure(GO:0032161)
0.1 0.7 GO:0033176 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) vacuolar proton-transporting V-type ATPase complex(GO:0016471) proton-transporting V-type ATPase complex(GO:0033176) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 0.4 GO:0031518 CBF3 complex(GO:0031518)
0.1 3.3 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 2.1 GO:0031201 SNARE complex(GO:0031201)
0.1 0.3 GO:0005797 Golgi medial cisterna(GO:0005797)
0.1 1.2 GO:0022626 cytosolic ribosome(GO:0022626)
0.1 0.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.5 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.1 1.1 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.1 1.1 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 0.4 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 1.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 12.5 GO:0005933 cellular bud(GO:0005933)
0.1 0.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 0.4 GO:0000782 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.1 0.1 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.1 0.2 GO:0005827 polar microtubule(GO:0005827) tubulin complex(GO:0045298)
0.1 0.7 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.1 0.3 GO:0000938 GARP complex(GO:0000938)
0.1 1.9 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.1 0.3 GO:0032545 CURI complex(GO:0032545)
0.1 0.5 GO:0005720 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.1 0.2 GO:0043529 GET complex(GO:0043529)
0.1 0.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 0.3 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 0.2 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.1 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.2 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.1 GO:0000131 incipient cellular bud site(GO:0000131)
0.0 2.4 GO:0030684 preribosome(GO:0030684)
0.0 4.3 GO:0005730 nucleolus(GO:0005730)
0.0 0.1 GO:0016587 Isw1 complex(GO:0016587)
0.0 0.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.2 GO:0071819 DUBm complex(GO:0071819)
0.0 0.1 GO:0042729 DASH complex(GO:0042729)
0.0 0.2 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.0 0.2 GO:0031414 N-terminal protein acetyltransferase complex(GO:0031414)
0.0 0.1 GO:0033186 CAF-1 complex(GO:0033186)
0.0 0.1 GO:0030907 MBF transcription complex(GO:0030907)
0.0 0.1 GO:0097042 extrinsic component of fungal-type vacuolar membrane(GO:0097042)
0.0 0.1 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.0 0.1 GO:0042575 DNA polymerase complex(GO:0042575)
0.0 0.2 GO:0000136 alpha-1,6-mannosyltransferase complex(GO:0000136)
0.0 0.2 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.0 0.3 GO:0045277 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.0 0.6 GO:0005844 polysome(GO:0005844)
0.0 0.1 GO:0034044 exomer complex(GO:0034044)
0.0 0.4 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.5 GO:0044445 cytosolic part(GO:0044445)
0.0 2.8 GO:0005840 ribosome(GO:0005840)
0.0 1.0 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.1 GO:0051233 spindle midzone(GO:0051233)
0.0 0.3 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.1 GO:0031501 mannosyltransferase complex(GO:0031501) dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.0 0.1 GO:0000417 HIR complex(GO:0000417)
0.0 0.3 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.0 GO:0000792 heterochromatin(GO:0000792)
0.0 0.1 GO:0000818 MIS12/MIND type complex(GO:0000444) nuclear MIS12/MIND complex(GO:0000818)
0.0 0.3 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.0 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.6 GO:0061645 actin cortical patch(GO:0030479) endocytic patch(GO:0061645)
0.0 0.1 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 0.0 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.1 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.0 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.0 0.0 GO:0034448 EGO complex(GO:0034448)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.2 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.9 5.4 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.8 3.1 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
0.8 2.3 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.8 3.0 GO:0016841 ammonia-lyase activity(GO:0016841)
0.7 3.0 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.6 2.6 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.6 1.8 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.6 1.8 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.6 1.7 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.5 2.1 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.5 2.5 GO:0008536 Ran GTPase binding(GO:0008536)
0.5 2.9 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.5 1.4 GO:0051219 phosphoprotein binding(GO:0051219)
0.4 1.3 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.4 5.0 GO:0005199 structural constituent of cell wall(GO:0005199)
0.4 1.9 GO:0008525 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.4 1.1 GO:0016872 intramolecular lyase activity(GO:0016872)
0.4 1.4 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.3 2.0 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.3 1.3 GO:0008310 3'-5'-exodeoxyribonuclease activity(GO:0008296) single-stranded DNA exodeoxyribonuclease activity(GO:0008297) single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.3 0.9 GO:0004525 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.3 1.5 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.3 1.1 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.3 1.1 GO:0004622 lysophospholipase activity(GO:0004622)
0.3 2.7 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.3 0.3 GO:0008097 5S rRNA binding(GO:0008097)
0.2 2.1 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.2 2.5 GO:0043495 protein anchor(GO:0043495)
0.2 0.9 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046) transcription factor activity, RNA polymerase I transcription factor recruiting(GO:0001186)
0.2 1.3 GO:0042124 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.2 0.6 GO:0000339 RNA cap binding(GO:0000339)
0.2 0.6 GO:0004805 trehalose-phosphatase activity(GO:0004805)
0.2 44.1 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 0.9 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.2 0.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 1.8 GO:0004497 monooxygenase activity(GO:0004497)
0.2 0.6 GO:0004338 glucan exo-1,3-beta-glucosidase activity(GO:0004338)
0.2 0.5 GO:0072341 modified amino acid binding(GO:0072341)
0.2 4.6 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.2 2.4 GO:0001054 RNA polymerase I activity(GO:0001054)
0.2 1.6 GO:0001056 RNA polymerase III activity(GO:0001056)
0.2 0.7 GO:0016417 S-acyltransferase activity(GO:0016417)
0.2 2.7 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.2 5.8 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.2 0.5 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.2 0.9 GO:0008312 7S RNA binding(GO:0008312)
0.1 0.7 GO:0070546 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.1 1.1 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 0.8 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 0.8 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.1 0.7 GO:0061135 endopeptidase regulator activity(GO:0061135)
0.1 1.3 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.1 0.9 GO:0019201 nucleotide kinase activity(GO:0019201)
0.1 0.4 GO:0015116 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.1 0.5 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.1 0.5 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.1 0.5 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 0.6 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.1 1.0 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.1 1.1 GO:0005216 ion channel activity(GO:0005216)
0.1 0.4 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 0.7 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)
0.1 0.3 GO:0070568 guanylyltransferase activity(GO:0070568)
0.1 1.7 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 1.1 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.3 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.1 0.6 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.1 2.2 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 0.3 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.1 1.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 0.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.3 GO:0001055 RNA polymerase II activity(GO:0001055)
0.1 1.5 GO:0030515 snoRNA binding(GO:0030515)
0.1 0.7 GO:0051213 dioxygenase activity(GO:0051213)
0.1 0.3 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 0.4 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 0.4 GO:0070403 NAD+ binding(GO:0070403)
0.1 2.3 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 0.4 GO:0019237 centromeric DNA binding(GO:0019237)
0.1 2.5 GO:0009055 electron carrier activity(GO:0009055)
0.1 0.1 GO:0048038 quinone binding(GO:0048038)
0.1 1.1 GO:0015616 DNA translocase activity(GO:0015616)
0.1 0.3 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 0.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 1.9 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.1 0.2 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 0.7 GO:0019904 protein domain specific binding(GO:0019904)
0.1 1.2 GO:0050661 NADP binding(GO:0050661)
0.1 0.3 GO:0005034 osmosensor activity(GO:0005034)
0.1 0.6 GO:0030276 clathrin binding(GO:0030276)
0.1 0.7 GO:0019843 rRNA binding(GO:0019843)
0.1 0.2 GO:0008252 nucleotidase activity(GO:0008252)
0.1 0.2 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.1 0.5 GO:0015079 potassium ion transmembrane transporter activity(GO:0015079)
0.1 0.3 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 0.7 GO:0051015 actin filament binding(GO:0051015)
0.0 0.2 GO:0016725 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 0.2 GO:0043139 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 1.0 GO:0016866 intramolecular transferase activity(GO:0016866)
0.0 0.4 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.3 GO:0001139 transcription factor activity, core RNA polymerase II recruiting(GO:0001139)
0.0 0.3 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.2 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.2 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.6 GO:0051287 NAD binding(GO:0051287)
0.0 0.1 GO:0031370 eukaryotic initiation factor 4G binding(GO:0031370)
0.0 1.1 GO:0016875 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 0.1 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.0 0.1 GO:0019238 cyclohydrolase activity(GO:0019238)
0.0 0.0 GO:0019003 GDP binding(GO:0019003)
0.0 0.2 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0 0.2 GO:0016408 C-acyltransferase activity(GO:0016408)
0.0 0.3 GO:0030295 protein kinase activator activity(GO:0030295)
0.0 0.9 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.1 GO:0003840 gamma-glutamyltransferase activity(GO:0003840)
0.0 0.2 GO:0031386 protein tag(GO:0031386)
0.0 0.2 GO:0000009 alpha-1,6-mannosyltransferase activity(GO:0000009)
0.0 0.6 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.1 GO:0004629 phospholipase C activity(GO:0004629)
0.0 0.1 GO:0008443 phosphofructokinase activity(GO:0008443)
0.0 0.7 GO:0003779 actin binding(GO:0003779)
0.0 0.1 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.6 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.1 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.0 0.2 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 0.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.3 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.8 GO:0004871 signal transducer activity(GO:0004871)
0.0 0.2 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.1 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.8 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.1 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.5 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.1 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 0.2 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 0.1 GO:0004312 fatty acid synthase activity(GO:0004312)
0.0 0.1 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.0 0.1 GO:0017108 5'-flap endonuclease activity(GO:0017108) flap endonuclease activity(GO:0048256)
0.0 0.2 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.2 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.1 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.1 GO:0004026 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.0 0.1 GO:0019239 deaminase activity(GO:0019239)
0.0 0.2 GO:0008483 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.0 0.2 GO:0070566 adenylyltransferase activity(GO:0070566)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 0.5 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 0.1 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.1 0.2 PID SHP2 PATHWAY SHP2 signaling
0.1 0.2 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.1 PID LKB1 PATHWAY LKB1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.8 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.3 4.9 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.3 0.9 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.2 0.9 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.2 1.2 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 0.4 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 0.4 REACTOME INFLUENZA LIFE CYCLE Genes involved in Influenza Life Cycle
0.1 0.3 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.1 0.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 0.3 REACTOME SIGNALLING TO ERKS Genes involved in Signalling to ERKs
0.1 0.3 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 0.3 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 0.5 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 0.3 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 0.1 REACTOME GPCR DOWNSTREAM SIGNALING Genes involved in GPCR downstream signaling
0.0 0.1 REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM Genes involved in Cytokine Signaling in Immune system
0.0 0.0 REACTOME CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION Genes involved in Cleavage of Growing Transcript in the Termination Region