Results for PDR3
Z-value: 0.49
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Transcription factors associated with PDR3
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
PDR3
|
S000000101 | Transcriptional activator of the pleiotropic drug resistance network |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YFR055W Show fit | 6.09 |
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner |
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| YFR056C Show fit | 5.42 |
Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W |
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| YOR153W Show fit | 4.74 |
Plasma membrane ATP-binding cassette (ABC) transporter, short-lived multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth |
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| YER131W Show fit | 4.64 |
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein |
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| YMR102C Show fit | 4.54 |
Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene |
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| YGL157W Show fit | 4.26 |
Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol) |
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| YLR413W Show fit | 4.12 |
Putative protein of unknown function; YLR413W is not an essential gene |
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| YPL250W-A Show fit | 4.08 |
Identified by fungal homology and RT-PCR |
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| YJR094W-A Show fit | 3.78 |
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein |
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| YDR345C Show fit | 3.62 |
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions |
Network of associatons between targets according to the STRING database.
First level regulatory network of PDR3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 27.0 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.7 | 12.1 | GO:0051029 | rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029) |
| 1.4 | 5.8 | GO:0046898 | response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898) |
| 1.9 | 5.6 | GO:0000098 | sulfur amino acid catabolic process(GO:0000098) |
| 0.1 | 5.1 | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) |
| 0.3 | 4.6 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.1 | 4.5 | GO:0006694 | steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126) |
| 0.6 | 4.3 | GO:0043137 | DNA replication, removal of RNA primer(GO:0043137) |
| 0.3 | 3.8 | GO:0006817 | phosphate ion transport(GO:0006817) |
| 0.3 | 3.7 | GO:0006415 | translational termination(GO:0006415) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 25.1 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.3 | 22.5 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 12.5 | GO:0005933 | cellular bud(GO:0005933) |
| 0.0 | 4.3 | GO:0005730 | nucleolus(GO:0005730) |
| 0.1 | 4.1 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 3.3 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 1.0 | 3.0 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.0 | 2.8 | GO:0005840 | ribosome(GO:0005840) |
| 0.2 | 2.4 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.1 | 2.4 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 44.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.2 | 5.8 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
| 0.9 | 5.4 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.4 | 5.0 | GO:0005199 | structural constituent of cell wall(GO:0005199) |
| 0.2 | 4.6 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 1.1 | 3.2 | GO:0042910 | xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910) |
| 0.8 | 3.1 | GO:0000297 | spermine transmembrane transporter activity(GO:0000297) |
| 0.8 | 3.0 | GO:0016841 | ammonia-lyase activity(GO:0016841) |
| 0.7 | 3.0 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 0.5 | 2.9 | GO:0003906 | DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.2 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.2 | 0.5 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 0.2 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.1 | 0.2 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 0.1 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.0 | 0.1 | PID LKB1 PATHWAY | LKB1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.9 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 0.6 | 4.8 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 0.2 | 1.2 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.3 | 0.9 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.2 | 0.9 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.1 | 0.5 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.1 | 0.4 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 0.4 | REACTOME INFLUENZA LIFE CYCLE | Genes involved in Influenza Life Cycle |
| 0.1 | 0.3 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.1 | 0.3 | REACTOME SIGNALLING TO ERKS | Genes involved in Signalling to ERKs |