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Results for PDR1

Z-value: 0.59

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Transcription factors associated with PDR1

Gene Symbol Gene ID Gene Info
PDR1
S000002981 Transcription factor that regulates the pleiotropic drug response

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PDR1YGL013C-0.572.5e-03Click!

Activity profile of PDR1 motif

Sorted Z-values of PDR1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YMR102C 8.16 Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
YJR094W-A 7.76
RPL43B
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YOR153W 7.74
PDR5
Plasma membrane ATP-binding cassette (ABC) transporter, short-lived multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth
YFR055W 6.74
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YER131W 6.23
RPS26B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YFR056C 5.84 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YDR345C 5.52
HXT3
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YGL209W 5.01
MIG2
Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter
YPL250W-A 5.00 Identified by fungal homology and RT-PCR
YDR044W 4.98
HEM13
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YGL157W 4.96 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YLR413W 4.74 Putative protein of unknown function; YLR413W is not an essential gene
YDR279W 4.03
RNH202
Ribonuclease H2 subunit, required for RNase H2 activity
YIL056W 3.96
VHR1
Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations
YGR108W 3.10
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YNL231C 3.08
PDR16
Phosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p, localizes to lipid particles and microsomes, controls levels of various lipids, may regulate lipid synthesis, homologous to Pdr17p
YNL178W 3.02
RPS3
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YOR050C 2.98 Hypothetical protein
YJL158C 2.95
CIS3
Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
YCL063W 2.90
VAC17
Protein involved in vacuole inheritance; acts as a vacuole-specific receptor for myosin Myo2p
YGR280C 2.77
PXR1
Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain
YDR502C 2.76
SAM2
S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YKR075C 2.71 Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YDR002W 2.70
YRB1
Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1
YKR092C 2.70
SRP40
Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YJL153C 2.67
INO1
Inositol 1-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
YPL062W 2.64 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation
YOR315W 2.56
SFG1
Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
YDR025W 2.54
RPS11A
Protein component of the small (40S) ribosomal subunit; identical to Rps11Bp and has similarity to E. coli S17 and rat S11 ribosomal proteins
YLR075W 2.54
RPL10
Protein component of the large (60S) ribosomal subunit, responsible for joining the 40S and 60S subunits; regulates translation initiation; has similarity to rat L10 ribosomal protein and to members of the QM gene family
YKL096W-A 2.53
CWP2
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YGR249W 2.51
MGA1
Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants
YOR369C 2.44
RPS12
Protein component of the small (40S) ribosomal subunit; has similarity to rat ribosomal protein S12
YOR163W 2.39
DDP1
Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; has high specificity for diadenosine hexa- and pentaphosphates; member of the MutT family of nucleotide hydrolases
YPR148C 2.36 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YER177W 2.35
BMH1
14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
YHR136C 2.27
SPL2
Protein with similarity to cyclin-dependent kinase inhibitors, overproduction suppresses a plc1 null mutation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YPR119W 2.25
CLB2
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YPR157W 2.24 Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YML026C 2.21
RPS18B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Ap and has similarity to E. coli S13 and rat S18 ribosomal proteins
YCL064C 2.17
CHA1
Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine
YOR327C 2.17
SNC2
Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins
YER130C 2.12 Hypothetical protein
YGR052W 2.04
FMP48
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
YGR214W 2.02
RPS0A
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YHR128W 1.99
FUR1
Uracil phosphoribosyltransferase, synthesizes UMP from uracil; involved in the pyrimidine salvage pathway
YJR070C 1.98
LIA1
Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyses hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning
YIL118W 1.95
RHO3
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YJR071W 1.89 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR143C 1.81
SUP45
Polypeptide release factor involved in translation termination; mutant form acts as a recessive omnipotent suppressor
YMR015C 1.81
ERG5
C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
YPL249C-A 1.80
RPL36B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Ap and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA
YLR333C 1.78
RPS25B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Ap and has similarity to rat S25 ribosomal protein
YBR048W 1.77
RPS11B
Protein component of the small (40S) ribosomal subunit; identical to Rps11Ap and has similarity to E. coli S17 and rat S11 ribosomal proteins
YJR123W 1.74
RPS5
Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteins
YOL124C 1.73
TRM11
Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
YDL047W 1.72
SIT4
Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
YDL023C 1.72 Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
YGR050C 1.71 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHL028W 1.68
WSC4
ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3
YLR448W 1.66
RPL6B
Protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Ap and to rat L6 ribosomal protein; binds to 5.8S rRNA
YDR072C 1.66
IPT1
Inositolphosphotransferase 1, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), which is the most abundant sphingolipid in cells, mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media
YBR257W 1.64
POP4
Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; binds to the RPR1 RNA subunit in Rnase P
YER137C 1.63 Putative protein of unknown function
YLL028W 1.63
TPO1
Polyamine transporter that recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane
YLR349W 1.62 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C
YIR021W 1.61
MRS1
Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YGL179C 1.56
TOS3
Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YLR348C 1.55
DIC1
Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix
YBL085W 1.52
BOI1
Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
YBL063W 1.52
KIP1
Kinesin-related motor protein required for mitotic spindle assembly and chromosome segregation; functionally redundant with Cin8p
YDR033W 1.51
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YDL022W 1.48
GPD1
NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p
YCR004C 1.48
YCP4
Protein of unknown function, has sequence and structural similarity to flavodoxins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YHR021C 1.47
RPS27B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Ap and has similarity to rat S27 ribosomal protein
YMR290W-A 1.43 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YLR154C 1.43
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YLR301W 1.42 Protein of unknown function that interacts with Sec72p
YPL239W 1.42
YAR1
Cytoplasmic ankyrin-repeat containing protein of unknown function, proposed to link the processes of 40S ribosomal subunit biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock
YGR051C 1.40 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene
YLR314C 1.40
CDC3
Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YIL133C 1.40
RPL16A
N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
YMR290C 1.39
HAS1
ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YDR381W 1.37
YRA1
Nuclear protein that binds to RNA and to Mex67p, required for export of poly(A)+ mRNA from the nucleus; member of the REF (RNA and export factor binding proteins) family; another family member, Yra2p, can substitute for Yra1p function
YMR246W 1.37
FAA4
Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipids
YMR266W 1.36
RSN1
Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant
YDR278C 1.33 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL211C 1.33 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YOL123W 1.32
HRP1
Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences
YHR137W 1.31
ARO9
Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism
YBR256C 1.30
RIB5
Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway
YIL011W 1.30
TIR3
Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth
YDL143W 1.30
CCT4
Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YHR010W 1.30
RPL27A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Bp and has similarity to rat L27 ribosomal protein
YGR264C 1.30
MES1
Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs
YGR251W 1.29 Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YMR083W 1.29
ADH3
Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YKL218C 1.28
SRY1
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YAL003W 1.28
EFB1
Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site
YJR094C 1.27
IME1
Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
YOR108W 1.27
LEU9
Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant
YJL148W 1.27
RPA34
RNA polymerase I subunit A34.5
YJL200C 1.27
ACO2
Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
YMR009W 1.26
ADI1
Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions
YPL137C 1.26
GIP3
Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments
YPL177C 1.25
CUP9
Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription
YGR265W 1.25 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase
YMR208W 1.24
ERG12
Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
YML075C 1.24
HMG1
One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae
YLR154W-A 1.24 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YLR441C 1.23
RPS1A
Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Bp and has similarity to rat S3a ribosomal protein
YLR154W-B 1.22 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YHR013C 1.22
ARD1
Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
YLR099W-A 1.22 Putative protein of unknown function
YDR073W 1.21
SNF11
Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p
YGR034W 1.20
RPL26B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Ap and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA
YNR013C 1.20
PHO91
Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YKL110C 1.19
KTI12
Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YJR043C 1.17
POL32
Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p
YPR074C 1.16
TKL1
Transketolase, similar to Tkl2p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YDR041W 1.15
RSM10
Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
YJL011C 1.15
RPC17
RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex
YPR014C 1.14 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene
YIL148W 1.12
RPL40A
Fusion protein, identical to Rpl40Bp, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes
YMR006C 1.12
PLB2
Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine
YOR025W 1.11
HST3
Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
YNL289W 1.11
PCL1
Pho85 cyclin of the Pcl1,2-like subfamily, involved in entry into the mitotic cell cycle and regulation of morphogenesis, localizes to sites of polarized cell growth
YKL165C 1.10
MCD4
Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes
YHR068W 1.10
DYS1
Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric
YDR091C 1.09
RLI1
Essential iron-sulfur protein required for ribosome biogenesis and translation initiation; facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit; predicted ABC family ATPase
YKL052C 1.09
ASK1
Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases
YFL015C 1.07 Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
YFR054C 1.06 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL012C 1.06
HTZ1
Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
YNL301C 1.06
RPL18B
Protein component of the large (60S) ribosomal subunit, identical to Rpl18Ap and has similarity to rat L18 ribosomal protein
YGR253C 1.05
PUP2
Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
YOL101C 1.04
IZH4
Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism
YLR367W 1.04
RPS22B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Ap and has similarity to E. coli S8 and rat S15a ribosomal proteins
YDR534C 1.03
FIT1
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YKL180W 1.03
RPL17A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Bp and has similarity to E. coli L22 and rat L17 ribosomal proteins; copurifies with the Dam1 complex (aka DASH complex)
YLR300W 1.02
EXG1
Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes
YBL006C 1.02
LDB7
Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
YFL015W-A 1.01 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR159W 1.01
IFA38
Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides
YAL053W 1.01
FLC2
Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance
YLR355C 1.00
ILV5
Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA and found in mitochondrial nucleoids
YLR312W-A 0.99
MRPL15
Mitochondrial ribosomal protein of the large subunit
YHR216W 0.99
IMD2
Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation
YBR210W 0.99
ERV15
Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p
YDR098C 0.99
GRX3
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YPL112C 0.97
PEX25
Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p
YGR121W-A 0.97 Putative protein of unknown function
YKR074W 0.97
AIM29
Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YDL022C-A 0.96 Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene DIA3; identified by fungal homology and RT-PCR
YGR128C 0.96
UTP8
Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YHR149C 0.96
SKG6
Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
YGR242W 0.96 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
YKR093W 0.95
PTR2
Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
YDR040C 0.95
ENA1
P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance
YDR133C 0.94 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YJL162C 0.93
JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YDR509W 0.92 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR108W 0.92
ILV2
Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control
YDR074W 0.92
TPS2
Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway
YDR508C 0.92
GNP1
High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids
YMR033W 0.91
ARP9
Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
YJL115W 0.91
ASF1
Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition
YML043C 0.91
RRN11
Protein required for rDNA transcription by RNA polymerase I, component of the core factor (CF) of rDNA transcription factor, which also contains Rrn6p and Rrn7p
YOL011W 0.90
PLB3
Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro
YER036C 0.89
ARB1
ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p
YKL068W-A 0.89 Putative protein of unknown function; identified by homology to Ashbya gossypii
YKL051W 0.88
SFK1
Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
YNL175C 0.87
NOP13
Protein of unknown function, localizes to the nucleolus and nucleoplasm; contains an RNA recognition motif (RRM) and has similarity to Nop12p, which is required for processing of pre-18S rRNA
YHR081W 0.87
LRP1
Substrate-specific nuclear cofactor for exosome activity in the processing of stable RNAs; required for telomere length maintenance; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination
YKL120W 0.86
OAC1
Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, and thiosulfate; member of the mitochondrial carrier family
YDL048C 0.86
STP4
Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p
YGR241C 0.86
YAP1802
Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1801p, member of the AP180 protein family
YGR180C 0.86
RNR4
Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
YBL092W 0.85
RPL32
Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing
YLR048W 0.84
RPS0B
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Ap; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YOR008C-A 0.84 Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres
YIL164C 0.84
NIT1
Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene
YHR071C-A 0.83 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF ERG7/YHR072W
YCL024W 0.83
KCC4
Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p
YKL181W 0.83
PRS1
5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
YIL076W 0.83
SEC28
Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth
YOR313C 0.83
SPS4
Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage
YJL198W 0.83
PHO90
Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YER120W 0.82
SCS2
Integral ER membrane protein that regulates phospholipid metabolism via an interaction with the FFAT motif of Opi1p, also involved in telomeric silencing, disruption causes inositol auxotrophy above 34 degrees C, VAP homolog
YER074W 0.80
RPS24A
Protein component of the small (40S) ribosomal subunit; identical to Rps24Bp and has similarity to rat S24 ribosomal protein
YOR385W 0.79 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene
YMR001C 0.79
CDC5
Polo-like kinase with similarity to Xenopus Plx1 and S. pombe Plo1p; found at bud neck, nucleus and SPBs; has multiple functions in mitosis and cytokinesis through phosphorylation of substrates; may be a Cdc28p substrate
YER012W 0.79
PRE1
Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
YDR500C 0.79
RPL37B
Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Ap and to rat L37 ribosomal protein
YGL009C 0.78
LEU1
Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway
YBR106W 0.78
PHO88
Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations
YDR274C 0.78 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR051C 0.78 Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
YGR017W 0.78 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
YIL021W 0.77
RPB3
RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit

Network of associatons between targets according to the STRING database.

First level regulatory network of PDR1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 8.8 GO:0014070 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
2.1 6.3 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
1.4 5.8 GO:1900434 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
1.0 18.1 GO:0051029 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
0.9 6.6 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.9 6.0 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
0.8 3.2 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.8 3.2 GO:0000296 spermine transport(GO:0000296)
0.8 2.3 GO:0051439 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.8 3.0 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
0.7 2.9 GO:1904357 negative regulation of telomere maintenance via telomerase(GO:0032211) negative regulation of telomere maintenance via telomere lengthening(GO:1904357)
0.7 2.1 GO:0006798 polyphosphate catabolic process(GO:0006798)
0.7 5.0 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.7 2.1 GO:0006567 threonine catabolic process(GO:0006567)
0.6 2.5 GO:0046490 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490)
0.6 0.6 GO:0045901 positive regulation of translational elongation(GO:0045901)
0.5 2.1 GO:0010138 pyrimidine ribonucleotide salvage(GO:0010138) pyrimidine nucleotide salvage(GO:0032262) pyrimidine nucleoside salvage(GO:0043097) UMP salvage(GO:0044206)
0.5 1.5 GO:0030541 plasmid partitioning(GO:0030541)
0.5 1.5 GO:2000877 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
0.5 2.0 GO:0090338 regulation of formin-nucleated actin cable assembly(GO:0090337) positive regulation of formin-nucleated actin cable assembly(GO:0090338)
0.5 1.9 GO:0035337 fatty-acyl-CoA metabolic process(GO:0035337)
0.5 1.4 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.5 6.5 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.4 2.1 GO:0009098 leucine biosynthetic process(GO:0009098)
0.4 5.4 GO:0006415 translational termination(GO:0006415)
0.4 4.3 GO:0006817 phosphate ion transport(GO:0006817)
0.4 3.5 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.4 1.5 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.4 2.1 GO:0006021 inositol biosynthetic process(GO:0006021)
0.3 1.0 GO:0019673 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
0.3 1.0 GO:0042992 negative regulation of transcription factor import into nucleus(GO:0042992)
0.3 0.6 GO:0033262 regulation of nuclear cell cycle DNA replication(GO:0033262)
0.3 0.8 GO:0008272 sulfate transport(GO:0008272)
0.3 1.4 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.3 0.3 GO:0031120 snRNA pseudouridine synthesis(GO:0031120) snRNA modification(GO:0040031)
0.3 1.1 GO:0015867 ATP transport(GO:0015867)
0.3 1.6 GO:0009099 valine biosynthetic process(GO:0009099)
0.3 1.3 GO:0043102 L-methionine biosynthetic process from methylthioadenosine(GO:0019509) amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
0.3 33.9 GO:0002181 cytoplasmic translation(GO:0002181)
0.3 1.1 GO:0015883 FAD transport(GO:0015883)
0.3 2.6 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.3 1.3 GO:0006177 GMP biosynthetic process(GO:0006177)
0.3 1.0 GO:0030497 fatty acid elongation(GO:0030497)
0.3 0.8 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.2 1.0 GO:0042938 dipeptide transport(GO:0042938)
0.2 3.2 GO:0000921 septin ring assembly(GO:0000921)
0.2 0.7 GO:0019401 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.2 0.5 GO:0019408 polyprenol metabolic process(GO:0016093) polyprenol biosynthetic process(GO:0016094) dolichol metabolic process(GO:0019348) dolichol biosynthetic process(GO:0019408)
0.2 2.5 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
0.2 0.9 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
0.2 0.7 GO:0061422 positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH(GO:0061422)
0.2 0.5 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.2 1.1 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.2 3.0 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.2 0.4 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.2 1.0 GO:0046417 chorismate metabolic process(GO:0046417)
0.2 1.0 GO:0046219 tryptophan biosynthetic process(GO:0000162) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
0.2 2.0 GO:0006547 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.2 0.8 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.2 1.8 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.2 0.6 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.2 3.5 GO:0006334 nucleosome assembly(GO:0006334)
0.2 6.6 GO:0016126 steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126)
0.2 0.6 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.2 1.3 GO:0009231 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.2 0.6 GO:0031555 transcriptional attenuation(GO:0031555) transcription antitermination(GO:0031564)
0.2 1.6 GO:0034965 intronic snoRNA processing(GO:0031070) intronic box C/D snoRNA processing(GO:0034965)
0.2 2.7 GO:0031498 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.2 0.5 GO:0044818 mitotic G2/M transition checkpoint(GO:0044818)
0.2 0.5 GO:0001109 promoter clearance during DNA-templated transcription(GO:0001109) promoter clearance from RNA polymerase II promoter(GO:0001111)
0.2 2.3 GO:0007120 axial cellular bud site selection(GO:0007120)
0.2 0.9 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.2 0.5 GO:0043069 negative regulation of apoptotic process(GO:0043066) negative regulation of programmed cell death(GO:0043069) negative regulation of cell death(GO:0060548)
0.2 1.5 GO:0071039 U5 snRNA 3'-end processing(GO:0034476) nuclear polyadenylation-dependent CUT catabolic process(GO:0071039)
0.2 0.8 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.2 1.0 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.2 2.3 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.2 2.9 GO:0000011 vacuole inheritance(GO:0000011)
0.2 0.2 GO:0071482 cellular response to radiation(GO:0071478) cellular response to light stimulus(GO:0071482)
0.2 1.1 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.2 0.6 GO:0071406 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
0.2 0.3 GO:0051865 protein autoubiquitination(GO:0051865)
0.2 0.3 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.2 0.3 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
0.2 0.5 GO:0033241 regulation of cellular amine catabolic process(GO:0033241)
0.1 0.7 GO:0060277 obsolete negative regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0060277)
0.1 0.7 GO:0006814 sodium ion transport(GO:0006814)
0.1 0.3 GO:0070827 chromatin maintenance(GO:0070827)
0.1 3.3 GO:0006885 regulation of pH(GO:0006885)
0.1 0.6 GO:0006797 polyphosphate metabolic process(GO:0006797)
0.1 0.9 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.1 3.4 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.1 0.4 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.1 1.1 GO:0000376 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.1 0.7 GO:0007030 Golgi organization(GO:0007030)
0.1 2.4 GO:0030488 tRNA methylation(GO:0030488)
0.1 1.5 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.1 1.1 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.1 0.4 GO:0038032 termination of signal transduction(GO:0023021) termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.1 0.6 GO:0007009 plasma membrane organization(GO:0007009)
0.1 1.7 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.1 0.2 GO:0033865 coenzyme A metabolic process(GO:0015936) nucleoside bisphosphate metabolic process(GO:0033865) ribonucleoside bisphosphate metabolic process(GO:0033875) purine nucleoside bisphosphate metabolic process(GO:0034032)
0.1 1.0 GO:0009395 phospholipid catabolic process(GO:0009395)
0.1 3.8 GO:0098876 Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.1 0.8 GO:0006901 vesicle coating(GO:0006901)
0.1 0.6 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.1 0.5 GO:0006344 maintenance of chromatin silencing(GO:0006344) maintenance of chromatin silencing at telomere(GO:0035392) protein targeting to nuclear inner membrane(GO:0036228)
0.1 0.4 GO:0006857 oligopeptide transport(GO:0006857)
0.1 1.5 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.1 2.4 GO:0009267 cellular response to starvation(GO:0009267)
0.1 0.3 GO:0046677 response to antibiotic(GO:0046677)
0.1 3.8 GO:1902593 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) nuclear import(GO:0051170) single-organism nuclear import(GO:1902593)
0.1 0.3 GO:0043171 peptide catabolic process(GO:0043171)
0.1 0.8 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.1 0.9 GO:0006882 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.1 0.8 GO:0016559 peroxisome fission(GO:0016559)
0.1 2.0 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.1 2.1 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 1.0 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 0.4 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) negative regulation of actin nucleation(GO:0051126)
0.1 0.8 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.1 1.4 GO:0006379 mRNA cleavage(GO:0006379)
0.1 0.2 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.1 1.1 GO:0006098 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.1 0.2 GO:0033559 unsaturated fatty acid biosynthetic process(GO:0006636) unsaturated fatty acid metabolic process(GO:0033559)
0.1 1.4 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.1 0.1 GO:0000304 response to singlet oxygen(GO:0000304)
0.1 0.7 GO:0006450 regulation of translational fidelity(GO:0006450)
0.1 0.3 GO:0018196 peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279)
0.1 2.2 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.1 0.2 GO:1901977 regulation of cell cycle checkpoint(GO:1901976) negative regulation of cell cycle checkpoint(GO:1901977) regulation of DNA damage checkpoint(GO:2000001) negative regulation of DNA damage checkpoint(GO:2000002) negative regulation of response to DNA damage stimulus(GO:2001021)
0.1 0.6 GO:0006037 cell wall chitin metabolic process(GO:0006037)
0.1 0.5 GO:0001402 signal transduction involved in filamentous growth(GO:0001402)
0.1 0.3 GO:0006657 CDP-choline pathway(GO:0006657)
0.1 1.5 GO:0071428 ribosomal subunit export from nucleus(GO:0000054) ribosome localization(GO:0033750) establishment of ribosome localization(GO:0033753) rRNA-containing ribonucleoprotein complex export from nucleus(GO:0071428)
0.1 0.5 GO:0030011 maintenance of cell polarity(GO:0030011)
0.1 0.4 GO:0042823 pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823) aldehyde biosynthetic process(GO:0046184)
0.1 1.2 GO:0045047 protein targeting to ER(GO:0045047)
0.1 0.1 GO:0043902 positive regulation of multi-organism process(GO:0043902)
0.1 1.8 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.1 0.3 GO:0035376 sterol import(GO:0035376)
0.1 0.1 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.1 0.3 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.1 0.2 GO:0051318 mitotic G1 phase(GO:0000080) G1 phase(GO:0051318)
0.1 0.2 GO:0015691 cadmium ion transport(GO:0015691)
0.1 0.5 GO:0016233 telomere capping(GO:0016233)
0.1 0.1 GO:0032368 regulation of lipid transport(GO:0032368)
0.1 0.2 GO:0007535 donor selection(GO:0007535)
0.1 0.3 GO:1901879 regulation of actin filament depolymerization(GO:0030834) negative regulation of actin filament depolymerization(GO:0030835) barbed-end actin filament capping(GO:0051016) actin filament capping(GO:0051693) regulation of protein depolymerization(GO:1901879) negative regulation of protein depolymerization(GO:1901880)
0.1 0.2 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.1 1.4 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.1 0.8 GO:0031929 TOR signaling(GO:0031929)
0.1 1.1 GO:0032508 DNA duplex unwinding(GO:0032508)
0.1 0.1 GO:0009202 deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
0.1 0.2 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.1 0.5 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.1 0.5 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.1 0.9 GO:0006414 translational elongation(GO:0006414)
0.1 0.1 GO:0015809 arginine transport(GO:0015809)
0.1 1.8 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.1 0.2 GO:0016578 histone deubiquitination(GO:0016578)
0.1 0.2 GO:0019357 nicotinate nucleotide biosynthetic process(GO:0019357) nicotinate nucleotide salvage(GO:0019358) pyridine nucleotide salvage(GO:0019365) nicotinate nucleotide metabolic process(GO:0046497)
0.1 0.2 GO:0006378 mRNA polyadenylation(GO:0006378)
0.1 0.5 GO:0008298 intracellular mRNA localization(GO:0008298)
0.0 0.8 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 1.5 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.4 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.2 GO:0000730 meiotic DNA recombinase assembly(GO:0000707) DNA recombinase assembly(GO:0000730)
0.0 0.1 GO:0061572 actin filament bundle assembly(GO:0051017) actin filament bundle organization(GO:0061572)
0.0 0.0 GO:0031590 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.0 3.1 GO:0006364 rRNA processing(GO:0006364)
0.0 0.1 GO:0016074 snoRNA metabolic process(GO:0016074)
0.0 0.1 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.0 1.1 GO:0051169 nucleocytoplasmic transport(GO:0006913) nuclear transport(GO:0051169)
0.0 0.1 GO:0043489 RNA stabilization(GO:0043489) mRNA stabilization(GO:0048255)
0.0 0.1 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.2 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.2 GO:0046020 negative regulation of transcription by pheromones(GO:0045996) negative regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046020)
0.0 0.4 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.2 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.1 GO:0042594 response to starvation(GO:0042594)
0.0 0.1 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.0 0.1 GO:0031930 mitochondria-nucleus signaling pathway(GO:0031930)
0.0 0.4 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413) peptidyl-proline modification(GO:0018208)
0.0 0.1 GO:0007119 budding cell isotropic bud growth(GO:0007119)
0.0 0.3 GO:0044396 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.0 0.4 GO:0006144 purine nucleobase metabolic process(GO:0006144)
0.0 0.3 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.1 GO:0071454 response to anoxia(GO:0034059) cellular response to anoxia(GO:0071454)
0.0 0.7 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.2 GO:0006526 arginine biosynthetic process(GO:0006526)
0.0 0.3 GO:0030474 spindle pole body duplication(GO:0030474)
0.0 0.1 GO:0006596 polyamine biosynthetic process(GO:0006596)
0.0 0.1 GO:0010674 negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010674)
0.0 0.2 GO:0006878 cellular copper ion homeostasis(GO:0006878) copper ion homeostasis(GO:0055070)
0.0 0.6 GO:0006413 translational initiation(GO:0006413)
0.0 0.3 GO:0030473 establishment of localization by movement along microtubule(GO:0010970) nuclear migration along microtubule(GO:0030473) organelle transport along microtubule(GO:0072384)
0.0 0.1 GO:0008299 isoprenoid metabolic process(GO:0006720) isoprenoid biosynthetic process(GO:0008299)
0.0 1.0 GO:0030036 actin cytoskeleton organization(GO:0030036)
0.0 0.1 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.1 GO:0048279 vesicle fusion with endoplasmic reticulum(GO:0048279)
0.0 0.3 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.1 GO:0015680 intracellular copper ion transport(GO:0015680)
0.0 0.0 GO:0070507 regulation of microtubule-based process(GO:0032886) regulation of microtubule cytoskeleton organization(GO:0070507)
0.0 0.3 GO:0009304 tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0 0.1 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 0.1 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.0 GO:0006517 protein deglycosylation(GO:0006517)
0.0 0.1 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.0 GO:0070676 intralumenal vesicle formation(GO:0070676)
0.0 0.4 GO:0016049 cell growth(GO:0016049)
0.0 0.1 GO:0000076 DNA replication checkpoint(GO:0000076)
0.0 0.1 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.0 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.1 GO:0034501 protein localization to kinetochore(GO:0034501)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.5 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.5 33.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.5 1.5 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.5 1.4 GO:0031415 NatA complex(GO:0031415)
0.4 1.3 GO:0070545 PeBoW complex(GO:0070545)
0.4 1.3 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
0.4 1.2 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.4 1.5 GO:0032160 septin filament array(GO:0032160)
0.4 29.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.3 1.3 GO:0070860 RNA polymerase I core factor complex(GO:0070860)
0.3 1.7 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.3 3.6 GO:0000786 nucleosome(GO:0000786)
0.3 0.8 GO:0030428 cell septum(GO:0030428)
0.3 1.5 GO:0005871 kinesin complex(GO:0005871)
0.2 4.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 1.7 GO:0000346 transcription export complex(GO:0000346)
0.2 2.8 GO:0016514 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.2 1.6 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.2 0.9 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.2 1.8 GO:0033101 cellular bud membrane(GO:0033101)
0.2 0.9 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.2 0.6 GO:0070985 TFIIK complex(GO:0070985)
0.2 1.4 GO:0034455 t-UTP complex(GO:0034455)
0.2 1.3 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.2 1.0 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.2 0.6 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.2 1.3 GO:0072686 mitotic spindle(GO:0072686)
0.2 1.6 GO:0005655 nucleolar ribonuclease P complex(GO:0005655) multimeric ribonuclease P complex(GO:0030681)
0.2 1.9 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.2 0.9 GO:0005641 nuclear envelope lumen(GO:0005641)
0.2 0.8 GO:0030689 Noc complex(GO:0030689)
0.2 0.8 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.2 1.8 GO:0005940 septin ring(GO:0005940)
0.2 2.1 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 0.6 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.1 0.9 GO:0048500 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.1 0.7 GO:0034518 RNA cap binding complex(GO:0034518)
0.1 0.4 GO:0071261 Ssh1 translocon complex(GO:0071261)
0.1 4.9 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 0.9 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 0.6 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 0.8 GO:0016272 prefoldin complex(GO:0016272)
0.1 0.4 GO:0044697 HICS complex(GO:0044697)
0.1 1.7 GO:0022626 cytosolic ribosome(GO:0022626)
0.1 1.6 GO:0016586 RSC complex(GO:0016586)
0.1 0.6 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.1 1.2 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 1.6 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.1 0.8 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 0.7 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.1 0.9 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 4.2 GO:0005811 lipid particle(GO:0005811)
0.1 2.1 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.1 0.8 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.1 1.2 GO:0034399 nuclear periphery(GO:0034399)
0.1 0.3 GO:0005827 polar microtubule(GO:0005827) tubulin complex(GO:0045298)
0.1 0.4 GO:0030907 MBF transcription complex(GO:0030907)
0.1 18.0 GO:0005933 cellular bud(GO:0005933)
0.1 0.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 0.7 GO:0051233 spindle midzone(GO:0051233)
0.1 0.3 GO:0070939 Dsl1p complex(GO:0070939)
0.1 0.4 GO:0000938 GARP complex(GO:0000938)
0.1 2.2 GO:0005802 trans-Golgi network(GO:0005802)
0.1 0.4 GO:0000131 incipient cellular bud site(GO:0000131)
0.1 0.3 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 0.6 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 0.5 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 0.2 GO:0042575 DNA polymerase complex(GO:0042575)
0.1 0.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.5 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.1 0.4 GO:0031414 N-terminal protein acetyltransferase complex(GO:0031414)
0.1 0.2 GO:0042729 DASH complex(GO:0042729)
0.1 0.4 GO:0000136 alpha-1,6-mannosyltransferase complex(GO:0000136)
0.1 0.3 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.1 0.3 GO:0005823 central plaque of spindle pole body(GO:0005823)
0.1 0.3 GO:0034990 mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990)
0.1 0.4 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.1 1.2 GO:0005685 U1 snRNP(GO:0005685)
0.1 0.2 GO:0033186 CAF-1 complex(GO:0033186)
0.1 0.2 GO:0043529 GET complex(GO:0043529)
0.1 0.6 GO:0000792 heterochromatin(GO:0000792)
0.1 8.8 GO:0005730 nucleolus(GO:0005730)
0.1 0.2 GO:0016587 Isw1 complex(GO:0016587)
0.1 0.6 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.1 0.1 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.0 0.2 GO:0034044 exomer complex(GO:0034044)
0.0 0.6 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.2 GO:0033179 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.3 GO:0042555 MCM complex(GO:0042555)
0.0 1.6 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 0.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.3 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.2 GO:0071819 DUBm complex(GO:0071819)
0.0 0.4 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.5 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.0 GO:0000133 polarisome(GO:0000133)
0.0 0.5 GO:0046695 SLIK (SAGA-like) complex(GO:0046695)
0.0 0.1 GO:0005825 half bridge of spindle pole body(GO:0005825)
0.0 0.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.2 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.0 0.1 GO:0035649 Nrd1 complex(GO:0035649)
0.0 3.5 GO:0005840 ribosome(GO:0005840)
0.0 0.1 GO:0097042 extrinsic component of fungal-type vacuolar membrane(GO:0097042)
0.0 0.5 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.2 GO:0045277 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.0 0.1 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 1.0 GO:0030479 actin cortical patch(GO:0030479) endocytic patch(GO:0061645)
0.0 0.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.1 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.3 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.1 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.1 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.3 GO:0005844 polysome(GO:0005844)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.1 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.1 GO:0000818 MIS12/MIND type complex(GO:0000444) nuclear MIS12/MIND complex(GO:0000818)
0.0 0.1 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.5 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.1 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540) spliceosomal tri-snRNP complex(GO:0097526)
0.0 0.1 GO:0044613 nuclear pore central transport channel(GO:0044613)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.7 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
1.4 5.5 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
1.3 5.0 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.9 2.7 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.9 5.3 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.8 2.5 GO:0016872 intramolecular lyase activity(GO:0016872)
0.8 3.4 GO:0016841 ammonia-lyase activity(GO:0016841)
0.8 3.2 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
0.8 2.3 GO:0051219 phosphoprotein binding(GO:0051219)
0.7 2.0 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.7 2.0 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.6 3.2 GO:0008536 Ran GTPase binding(GO:0008536)
0.6 3.1 GO:0008525 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.6 1.7 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.5 2.7 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.5 2.1 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.5 3.1 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.5 5.1 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.5 2.0 GO:0004622 lysophospholipase activity(GO:0004622)
0.5 1.8 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.4 1.3 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.4 1.7 GO:0004338 glucan exo-1,3-beta-glucosidase activity(GO:0004338)
0.3 2.1 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.3 3.0 GO:0004497 monooxygenase activity(GO:0004497)
0.3 1.0 GO:0004525 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.3 0.6 GO:0008097 5S rRNA binding(GO:0008097)
0.3 2.9 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.3 1.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.3 1.3 GO:0001186 core promoter sequence-specific DNA binding(GO:0001046) transcription factor activity, RNA polymerase I transcription factor recruiting(GO:0001186)
0.3 3.8 GO:0005199 structural constituent of cell wall(GO:0005199)
0.3 0.9 GO:0004805 trehalose-phosphatase activity(GO:0004805)
0.3 1.2 GO:0008310 3'-5'-exodeoxyribonuclease activity(GO:0008296) single-stranded DNA exodeoxyribonuclease activity(GO:0008297) single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.3 60.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.3 0.9 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.3 6.2 GO:0019901 protein kinase binding(GO:0019901)
0.3 3.1 GO:0043495 protein anchor(GO:0043495)
0.3 0.8 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.3 0.8 GO:0072341 modified amino acid binding(GO:0072341)
0.3 1.1 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.3 1.4 GO:0070546 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.3 1.1 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.3 0.8 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.3 3.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 0.7 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.2 0.7 GO:0070568 guanylyltransferase activity(GO:0070568)
0.2 0.9 GO:0001055 RNA polymerase II activity(GO:0001055)
0.2 1.4 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.2 0.7 GO:0000339 RNA cap binding(GO:0000339)
0.2 0.7 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.2 1.1 GO:0042124 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.2 0.9 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.2 3.0 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2 7.7 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.2 1.8 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.2 0.6 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.2 0.5 GO:0051010 microtubule plus-end binding(GO:0051010)
0.2 0.9 GO:0008312 7S RNA binding(GO:0008312)
0.2 0.7 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.2 0.8 GO:0070403 NAD+ binding(GO:0070403)
0.2 0.8 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.2 0.7 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.2 2.8 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.2 1.6 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.2 0.8 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.2 1.7 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.2 0.9 GO:0016408 C-acyltransferase activity(GO:0016408)
0.2 2.1 GO:0001054 RNA polymerase I activity(GO:0001054)
0.2 1.5 GO:0003777 microtubule motor activity(GO:0003777)
0.2 0.6 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 1.0 GO:0019201 nucleotide kinase activity(GO:0019201)
0.1 0.9 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 0.5 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 1.1 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 0.1 GO:0019003 GDP binding(GO:0019003)
0.1 3.6 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 0.4 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 2.0 GO:0015616 DNA translocase activity(GO:0015616)
0.1 1.2 GO:0001056 RNA polymerase III activity(GO:0001056)
0.1 1.7 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 0.3 GO:0015248 sterol transporter activity(GO:0015248)
0.1 1.1 GO:0005216 ion channel activity(GO:0005216)
0.1 1.7 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 0.5 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 0.9 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 0.9 GO:0019904 protein domain specific binding(GO:0019904)
0.1 0.4 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 0.5 GO:0001139 transcription factor activity, core RNA polymerase II recruiting(GO:0001139)
0.1 0.3 GO:0003680 AT DNA binding(GO:0003680)
0.1 0.7 GO:0030295 protein kinase activator activity(GO:0030295)
0.1 0.3 GO:0005034 osmosensor activity(GO:0005034)
0.1 0.4 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 0.4 GO:0008443 phosphofructokinase activity(GO:0008443)
0.1 2.4 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 1.5 GO:0030515 snoRNA binding(GO:0030515)
0.1 1.0 GO:0051015 actin filament binding(GO:0051015)
0.1 0.7 GO:0015079 potassium ion transmembrane transporter activity(GO:0015079)
0.1 1.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 1.0 GO:0050661 NADP binding(GO:0050661)
0.1 1.0 GO:0001671 ATPase activator activity(GO:0001671)
0.1 0.7 GO:0030276 clathrin binding(GO:0030276)
0.1 0.6 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 0.3 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.1 0.1 GO:0003840 gamma-glutamyltransferase activity(GO:0003840)
0.1 0.3 GO:0009378 four-way junction helicase activity(GO:0009378)
0.1 1.2 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.1 2.0 GO:0008135 translation factor activity, RNA binding(GO:0008135)
0.1 1.2 GO:0051287 NAD binding(GO:0051287)
0.1 0.8 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.1 3.3 GO:0003924 GTPase activity(GO:0003924)
0.1 0.8 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035) disulfide oxidoreductase activity(GO:0015036)
0.1 0.2 GO:0043141 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.1 0.5 GO:0000009 alpha-1,6-mannosyltransferase activity(GO:0000009)
0.1 1.4 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.1 0.3 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 0.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 0.3 GO:0019237 centromeric DNA binding(GO:0019237)
0.1 0.1 GO:0019238 cyclohydrolase activity(GO:0019238)
0.1 0.3 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.3 GO:0031386 protein tag(GO:0031386)
0.0 0.4 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.2 GO:0008106 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.0 0.6 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 0.2 GO:0032934 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.0 2.2 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.3 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.1 GO:0099516 ion antiporter activity(GO:0099516)
0.0 0.4 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 1.2 GO:0016875 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 0.5 GO:0019213 deacetylase activity(GO:0019213)
0.0 0.1 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.1 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.1 GO:0008252 nucleotidase activity(GO:0008252)
0.0 0.8 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.9 GO:0003779 actin binding(GO:0003779)
0.0 1.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.5 GO:0005525 GTP binding(GO:0005525) guanyl nucleotide binding(GO:0019001) guanyl ribonucleotide binding(GO:0032561)
0.0 0.1 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.0 0.3 GO:0032947 protein complex scaffold(GO:0032947)
0.0 0.3 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.1 GO:0008242 omega peptidase activity(GO:0008242)
0.0 0.1 GO:0005302 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.0 0.8 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds(GO:0016810)
0.0 0.2 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.0 GO:0008902 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.0 0.2 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.1 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 0.2 GO:0004312 fatty acid synthase activity(GO:0004312)
0.0 0.2 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 0.0 GO:0008144 drug binding(GO:0008144)
0.0 0.6 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.2 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 0.1 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.1 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 1.9 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 0.0 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 0.4 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.1 GO:0004864 protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
0.0 0.5 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 3.3 GO:0003723 RNA binding(GO:0003723)
0.0 0.1 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.0 0.7 GO:0008289 lipid binding(GO:0008289)
0.0 0.0 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 0.1 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.0 0.2 GO:0031491 nucleosome binding(GO:0031491)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 0.6 PID SHP2 PATHWAY SHP2 signaling
0.2 0.5 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.0 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.1 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.1 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.1 PID E2F PATHWAY E2F transcription factor network
0.0 0.1 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 0.2 PID ATR PATHWAY ATR signaling pathway
0.0 0.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 7.9 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.4 1.3 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.4 6.4 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.4 1.2 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.4 1.5 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.3 2.2 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.2 0.6 REACTOME SIGNALLING TO ERKS Genes involved in Signalling to ERKs
0.2 0.4 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.2 1.0 REACTOME SIGNALING BY GPCR Genes involved in Signaling by GPCR
0.2 0.5 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.2 0.3 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.1 0.7 REACTOME TRANSLATION Genes involved in Translation
0.1 0.3 REACTOME INFLUENZA LIFE CYCLE Genes involved in Influenza Life Cycle
0.0 0.1 REACTOME CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION Genes involved in Cleavage of Growing Transcript in the Termination Region
0.0 0.3 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.1 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.0 REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM Genes involved in Cytokine Signaling in Immune system
0.0 0.2 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation