Results for PDR1
Z-value: 0.59
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Transcription factors associated with PDR1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
PDR1
|
S000002981 | Transcription factor that regulates the pleiotropic drug response |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YMR102C Show fit | 8.16 |
Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene |
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| YJR094W-A Show fit | 7.76 |
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein |
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| YOR153W Show fit | 7.74 |
Plasma membrane ATP-binding cassette (ABC) transporter, short-lived multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth |
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| YFR055W Show fit | 6.74 |
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner |
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| YER131W Show fit | 6.23 |
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein |
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| YFR056C Show fit | 5.84 |
Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W |
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| YDR345C Show fit | 5.52 |
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions |
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| YGL209W Show fit | 5.01 |
Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter |
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| YPL250W-A Show fit | 5.00 |
Identified by fungal homology and RT-PCR |
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| YDR044W Show fit | 4.98 |
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p) |
Network of associatons between targets according to the STRING database.
First level regulatory network of PDR1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 33.9 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 1.0 | 18.1 | GO:0051029 | rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029) |
| 2.2 | 8.8 | GO:0014070 | response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898) |
| 0.9 | 6.6 | GO:0043137 | DNA replication, removal of RNA primer(GO:0043137) |
| 0.2 | 6.6 | GO:0016126 | steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126) |
| 0.5 | 6.5 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 2.1 | 6.3 | GO:0000098 | sulfur amino acid catabolic process(GO:0000098) |
| 0.9 | 6.0 | GO:0010696 | positive regulation of spindle pole body separation(GO:0010696) |
| 1.4 | 5.8 | GO:1900434 | filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436) |
| 0.4 | 5.4 | GO:0006415 | translational termination(GO:0006415) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 33.0 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.4 | 29.6 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 18.0 | GO:0005933 | cellular bud(GO:0005933) |
| 0.1 | 8.8 | GO:0005730 | nucleolus(GO:0005730) |
| 1.8 | 5.5 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.1 | 4.9 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.1 | 4.2 | GO:0005811 | lipid particle(GO:0005811) |
| 0.2 | 4.1 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.3 | 3.6 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 3.5 | GO:0005840 | ribosome(GO:0005840) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 60.2 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.2 | 7.7 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
| 0.3 | 6.2 | GO:0019901 | protein kinase binding(GO:0019901) |
| 1.9 | 5.7 | GO:0042910 | xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910) |
| 1.4 | 5.5 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 0.9 | 5.3 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.5 | 5.1 | GO:0001133 | RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133) |
| 1.3 | 5.0 | GO:0016634 | oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634) |
| 0.3 | 3.8 | GO:0005199 | structural constituent of cell wall(GO:0005199) |
| 0.1 | 3.6 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.3 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.2 | 0.6 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.2 | 0.5 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 0.2 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 0.1 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.1 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 0.1 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 0.1 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.0 | 0.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 0.0 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 7.9 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.4 | 6.4 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.3 | 2.2 | REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 0.4 | 1.5 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.4 | 1.3 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.4 | 1.2 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.2 | 1.0 | REACTOME SIGNALING BY GPCR | Genes involved in Signaling by GPCR |
| 0.1 | 0.7 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.2 | 0.6 | REACTOME SIGNALLING TO ERKS | Genes involved in Signalling to ERKs |
| 0.2 | 0.5 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |