Results for PBF2

Z-value: 2.50

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Transcription factors associated with PBF2

Gene Symbol Gene ID Gene Info
S000000890 Protein involved in rRNA and ribosome biogenesis

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of PBF2 motif

Sorted Z-values of PBF2 motif

Promoter Log-likelihood Transcript Gene Gene Info
YFR055W 35.49 Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YFR056C 30.52 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YKR092C 24.83 Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YER074W 18.72 Protein component of the small (40S) ribosomal subunit; identical to Rps24Bp and has similarity to rat S24 ribosomal protein
YER073W 18.37 Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed
YOR101W 17.22 GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes
YOR096W 16.43 Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
YPR148C 15.11 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YNL178W 14.89 Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YIR021W 14.08 Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YMR246W 13.04 Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipids
YDL055C 12.85 GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YOR340C 12.70 RNA polymerase I subunit A43
YLR062C 12.44 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YHR128W 12.31 Uracil phosphoribosyltransferase, synthesizes UMP from uracil; involved in the pyrimidine salvage pathway
YDL208W 12.01 Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing
YGR251W 11.96 Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YER137C 11.90 Putative protein of unknown function
YER146W 11.49 Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YDL148C 11.39 Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
YPL211W 11.35 Nucleolar protein required for 60S ribosome subunit biogenesis, constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p
YOL086C 11.26 Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YOL077C 10.88 Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif
YOL127W 10.68 Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 26S rRNA via a conserved C-terminal motif
YLR432W 10.64 Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
YNL112W 10.57 Essential ATP-dependent RNA helicase of the DEAD-box protein family, involved in nonsense-mediated mRNA decay and rRNA processing
YML123C 10.47 High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p
YNL248C 10.39 RNA polymerase I subunit A49
YJL010C 10.14 Essential component of pre-40S ribosomes that is required for early cleavages of 35S pre-rRNA and hence formation of 18S rRNA; binds RNA in vitro and contains multiple pumilio-like repeats
YBR154C 9.70 RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation
YMR290C 9.63 ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YDL051W 9.58 RNA binding protein required for maturation of tRNA and snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen
YOR272W 9.54 Constituent of 66S pre-ribosomal particles, required for maturation of the large ribosomal subunit
YGR128C 9.51 Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YMR290W-A 9.50 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YJL122W 9.47 Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p
YBL027W 9.35 Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Ap and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal
YLR355C 9.31 Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA and found in mitochondrial nucleoids
YKL081W 9.27 Translation elongation factor EF-1 gamma
YBL039C 9.21 Major CTP synthase isozyme (see also URA8), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis
YNL141W 9.12 Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome
YLR154C 9.11 Ribonuclease H2 subunit, required for RNase H2 activity
YEL053W-A 9.03 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YEL054C
YBL028C 9.00 Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
YGL055W 8.74 Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
YNL113W 8.74 RNA polymerase subunit, common to RNA polymerases I and III
YFR054C 8.74 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKR093W 8.69 Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
YMR217W 8.68 GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation
YIL091C 8.61 Protein required for cell viability
YPL143W 8.59 N-terminally acetylated ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Bp and has similarity to rat L35a; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable
YKL164C 8.59 O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle
YIL118W 8.56 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YML121W 8.55 Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
YLR449W 8.55 Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones
YPR010C 8.46 RNA polymerase I subunit A135
YPL250W-A 8.30 Identified by fungal homology and RT-PCR
YKR081C 8.28 Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles
YGR151C 8.24 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C
YLR154W-A 8.01 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YMR131C 8.00 Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p
YLR009W 7.96 Essential protein with similarity to Rpl24Ap and Rpl24Bp, associated with pre-60S ribosomal subunits and required for ribosomal large subunit biogenesis
YJR070C 7.93 Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyses hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning
YPL090C 7.80 Protein component of the small (40S) ribosomal subunit; identical to Rps6Bp and has similarity to rat S6 ribosomal protein
YLR154W-B 7.77 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YKL009W 7.76 Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus
YOR271C 7.74 Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
YLR075W 7.73 Protein component of the large (60S) ribosomal subunit, responsible for joining the 40S and 60S subunits; regulates translation initiation; has similarity to rat L10 ribosomal protein and to members of the QM gene family
YML043C 7.66 Protein required for rDNA transcription by RNA polymerase I, component of the core factor (CF) of rDNA transcription factor, which also contains Rrn6p and Rrn7p
YMR049C 7.60 Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1
YHR066W 7.59 Constituent of 66S pre-ribosomal particles, required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family
YNL175C 7.56 Protein of unknown function, localizes to the nucleolus and nucleoplasm; contains an RNA recognition motif (RRM) and has similarity to Nop12p, which is required for processing of pre-18S rRNA
YOR004W 7.49 Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function
YJR071W 7.45 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL212C 7.45 tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA
YDL022C-A 7.35 Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene DIA3; identified by fungal homology and RT-PCR
YDL112W 7.33 2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs
YDL023C 7.30 Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
YKL096W-A 7.21 Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YLR068W 7.21 Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in processing the 35S rRNA primary transcript to generate the 20S and 27SA2 pre-rRNA transcripts
YIR026C 7.20 Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; transcription induced by low temperature and nitrogen starvation; member of the dual-specificity family of protein phosphatases
YDL014W 7.17 Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin
YNR053C 7.17 Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation
YAL059W 7.10 Protein of unknown function, localized in the nucleoplasm and the nucleolus, genetically interacts with MTR2 in 60S ribosomal protein subunit export
YLR406C 7.01 Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Ap and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p
YDR087C 6.98 Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles
YLR349W 6.95 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C
YJL148W 6.95 RNA polymerase I subunit A34.5
YGL029W 6.94 Protein involved in nucleolar integrity and processing of the pre-rRNA for the 60S ribosome subunit; transcript is induced in response to cytotoxic stress but not genotoxic stress
YPL093W 6.91 Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins
YDR399W 6.90 Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome
YPR163C 6.87 Translation initiation factor eIF-4B, has RNA annealing activity; contains an RNA recognition motif and binds to single-stranded RNA
YFR001W 6.72 Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles
YLR348C 6.69 Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix
YOL041C 6.64 Nucleolar protein, required for pre-25S rRNA processing; contains an RNA recognition motif (RRM) and has similarity to Nop13p, Nsr1p, and putative orthologs in Drosophila and S. pombe
YHR148W 6.60 Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA
YDR465C 6.60 Arginine methyltransferase; ribosomal protein L12 is a substrate
YGL078C 6.59 Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis
YDL150W 6.58 RNA polymerase III subunit C53
YGR280C 6.53 Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain
YGR155W 6.43 Cystathionine beta-synthase, catalyzes the synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis
YCR018C 6.42 Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YOL076W 6.42 Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly
YOR108W 6.42 Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant
YOR153W 6.42 Plasma membrane ATP-binding cassette (ABC) transporter, short-lived multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth
YDR385W 6.37 Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
YKL172W 6.35 Essential protein required for the maturation of 25S rRNA and 60S ribosomal subunit assembly, localizes to the nucleolus; constituent of 66S pre-ribosomal particles
YPL108W 6.35 Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YOR310C 6.30 Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA
YGR214W 6.29 Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YGR159C 6.24 Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
YGR123C 6.24 Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth; computational analyses suggest roles in phosphate metabolism and rRNA processing
YER102W 6.20 Protein component of the small (40S) ribosomal subunit; identical to Rps8Ap and has similarity to rat S8 ribosomal protein
YLR196W 6.18 Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily
YGL120C 6.18 RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome
YKR024C 6.17 Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis
YOL080C 6.11 Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly
YDR060W 6.07 Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein
YDL022W 6.06 NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p
YGR108W 6.04 B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YGR245C 6.02 Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis
YCL059C 5.99 Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit
YGR145W 5.99 Essential nucleolar protein of unknown function; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p
YAL025C 5.98 Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus
YLR409C 5.96 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YLL008W 5.95 Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles
YBR249C 5.93 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan
YLR180W 5.91 S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YFL015W-A 5.91 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL079W 5.89 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YJL050W 5.87 Dead-box family ATP dependent helicase required for mRNA export from the nucleus; co-factor of the exosome complex, required for 3' end formation of 5.8S rRNA
YBR142W 5.86 Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits
YHR089C 5.81 Protein component of the H/ACA snoRNP pseudouridylase complex, involved in the modification and cleavage of the 18S pre-rRNA
YDR120C 5.79 tRNA methyltransferase, localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
YFR031C-A 5.76 Protein component of the large (60S) ribosomal subunit, identical to Rpl2Bp and has similarity to E. coli L2 and rat L8 ribosomal proteins
YFL015C 5.75 Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
YKL099C 5.73 Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YNL247W 5.68 Essential protein of unknown function; may interact with ribosomes, based on co-purification experiments
YGR103W 5.68 Nucleolar protein involved in rRNA processing and 60S ribosomal subunit biogenesis; constituent of several different pre-ribosomal particles; required for exit from G0 and the initiation of cell proliferation
YJL200C 5.64 Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
YER126C 5.63 Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA
YNL114C 5.63 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit
YNR003C 5.56 RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex
YPL012W 5.55 Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; contains HEAT-repeats
YNL002C 5.54 Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs
YNL065W 5.53 Plasma membrane multidrug transporter of the major facilitator superfamily, confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids
YLR129W 5.52 Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex
YDR398W 5.51 Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YIR012W 5.51 Essential protein involved in a late step of 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay
YDR033W 5.49 Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YHR070C-A 5.48 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene TRM5/YHR070W
YCL036W 5.45 Protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation
YKL014C 5.45 Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit
YOR243C 5.45 Pseudouridine synthase, catalyzes pseudouridylation at position 35 in U2 snRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); Asp(256) mutation abolishes activity; conserved in archaea, some bacteria, and vertebrates
YNL089C 5.42 Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins
YIL056W 5.41 Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations
YER001W 5.40 Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
YJL009W 5.35 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex
YBR244W 5.35 Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YHR052W 5.35 Essential protein that interacts with proteasome components and has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles
YDL153C 5.33 Component of the small (ribosomal) subunit (SSU) processosome required for pre-18S rRNa processing; essential nucleolar protein that, when overproduced, disrupts silencing
YLL011W 5.32 Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p
YBL092W 5.31 Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing
YDR279W 5.30 Ribonuclease H2 subunit, required for RNase H2 activity
YPL086C 5.27 Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin
YPL239W 5.25 Cytoplasmic ankyrin-repeat containing protein of unknown function, proposed to link the processes of 40S ribosomal subunit biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock
YLR363W-A 5.21 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YDR101C 5.21 Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
YOR206W 5.20 Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors
YPL043W 5.19 Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)
YKL078W 5.17 Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis
YDR450W 5.15 Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins
YBR126W-A 5.15 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR126W-B; identified by gene-trapping, microarray analysis, and genome-wide homology searches
YHR197W 5.14 Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles
YER049W 5.13 Protein of unknown function; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; has a role in translation termination efficiency, mRNA poly(A) tail length and mRNA stability
YOR376W-A 5.13 Putative protein of unknown function; identified by fungal homology and RT-PCR
YOR025W 5.12 Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
YHR181W 5.12 Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YHR169W 5.10 Putative ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 40S ribosomal subunit
YLR413W 5.09 Putative protein of unknown function; YLR413W is not an essential gene
YDR021W 5.08 Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases
YNL110C 5.06 Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm
YGR086C 5.06 Primary component of eisosomes, which are large immobile cell cortex structures associated with endocytosis; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria
YHR196W 5.02 Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YJR145C 5.01 Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein
YMR123W 5.00 V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); overproduction confers resistance to Pichia farinosa killer toxin
YBL070C 4.99 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR118W 4.96 Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes
YJL069C 4.95 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YJR094W-A 4.95 Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YEL001C 4.95 Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
YGR200C 4.93 Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
YGL171W 4.92 ATP-dependent RNA helicase of the DEAD box family; required for 18S rRNA synthesis
YCR016W 4.92 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; YCR016W is not an essential gene
YDR083W 4.92 Nucleolar protein involved in rRNA processing, pre-rRNA cleavage at site A2; also involved in telomere maintenance; mutation is synthetically lethal with a gar1 mutation
YDR361C 4.89 Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport
YLR154W-C 4.84 Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YPL266W 4.84 Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing
YHR144C 4.82 Deoxycytidine monophosphate (dCMP) deaminase required for dCTP and dTTP synthesis; expression is NOT cell cycle regulated
YHR149C 4.81 Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p

Network of associatons between targets according to the STRING database.

First level regulatory network of PBF2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
11.8 35.5 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
6.0 29.9 GO:0006177 GMP biosynthetic process(GO:0006177)
5.9 17.8 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
5.7 17.1 GO:0034310 ethanol catabolic process(GO:0006068) primary alcohol catabolic process(GO:0034310)
5.1 20.2 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
4.3 12.9 GO:0040031 snRNA pseudouridine synthesis(GO:0031120) snRNA modification(GO:0040031)
4.3 12.9 GO:0009298 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
4.1 12.4 GO:0046083 purine nucleobase salvage(GO:0043096) adenine metabolic process(GO:0046083)
4.0 4.0 GO:0046037 GMP metabolic process(GO:0046037)
4.0 7.9 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
3.8 106.5 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
3.8 15.1 GO:0043097 pyrimidine ribonucleotide salvage(GO:0010138) pyrimidine nucleotide salvage(GO:0032262) pyrimidine nucleoside salvage(GO:0043097) UMP salvage(GO:0044206)
3.6 119.4 GO:0000027 ribosomal large subunit assembly(GO:0000027)
3.6 10.7 GO:0018195 peptidyl-arginine modification(GO:0018195) peptidyl-arginine methylation(GO:0018216)
3.4 162.1 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
3.3 13.4 GO:0035337 fatty-acyl-CoA metabolic process(GO:0035337)
3.3 9.9 GO:0071049 nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription(GO:0071049)
3.2 12.9 GO:0031167 rRNA methylation(GO:0031167)
3.2 57.5 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
3.1 9.2 GO:0009209 CTP biosynthetic process(GO:0006241) pyrimidine ribonucleoside triphosphate metabolic process(GO:0009208) pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209) CTP metabolic process(GO:0046036)
2.9 8.7 GO:0033559 unsaturated fatty acid biosynthetic process(GO:0006636) unsaturated fatty acid metabolic process(GO:0033559)
2.8 28.4 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
2.8 31.1 GO:0006817 phosphate ion transport(GO:0006817)
2.7 49.4 GO:0009304 tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797)
2.5 144.7 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
2.3 55.5 GO:0000054 ribosomal subunit export from nucleus(GO:0000054) ribosome localization(GO:0033750) establishment of ribosome localization(GO:0033753)
2.3 40.8 GO:0030488 tRNA methylation(GO:0030488)
2.2 6.7 GO:0034473 U1 snRNA 3'-end processing(GO:0034473)
2.1 6.4 GO:0045901 positive regulation of translational elongation(GO:0045901)
2.1 8.4 GO:0090338 regulation of formin-nucleated actin cable assembly(GO:0090337) positive regulation of formin-nucleated actin cable assembly(GO:0090338)
2.1 14.5 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
2.1 8.3 GO:0031057 negative regulation of histone modification(GO:0031057)
2.1 2.1 GO:0031590 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
2.1 172.7 GO:0006364 rRNA processing(GO:0006364)
2.0 6.1 GO:0018206 N-terminal peptidyl-methionine acetylation(GO:0017196) peptidyl-methionine modification(GO:0018206)
1.9 7.6 GO:0042780 tRNA 3'-end processing(GO:0042780)
1.9 9.4 GO:0009098 leucine biosynthetic process(GO:0009098)
1.8 5.5 GO:0031384 regulation of initiation of mating projection growth(GO:0031384)
1.8 14.7 GO:0000376 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
1.8 5.4 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
1.7 6.7 GO:0000296 spermine transport(GO:0000296)
1.6 9.9 GO:0009099 valine biosynthetic process(GO:0009099)
1.6 4.8 GO:0009219 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) deoxyribonucleoside monophosphate metabolic process(GO:0009162) pyrimidine deoxyribonucleoside monophosphate metabolic process(GO:0009176) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177) pyrimidine deoxyribonucleotide metabolic process(GO:0009219) pyrimidine deoxyribonucleotide biosynthetic process(GO:0009221) 2'-deoxyribonucleotide biosynthetic process(GO:0009265) 2'-deoxyribonucleotide metabolic process(GO:0009394) deoxyribose phosphate biosynthetic process(GO:0046385)
1.6 6.4 GO:0014070 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
1.6 10.9 GO:1902707 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
1.5 4.6 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900) tetrahydrofolylpolyglutamate biosynthetic process(GO:0046901)
1.5 6.1 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
1.5 5.9 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
1.5 5.9 GO:0009423 chorismate biosynthetic process(GO:0009423)
1.5 7.4 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
1.5 5.9 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
1.5 4.4 GO:0006529 asparagine biosynthetic process(GO:0006529)
1.5 4.4 GO:0015740 sulfate transport(GO:0008272) C4-dicarboxylate transport(GO:0015740)
1.5 1.5 GO:0032785 negative regulation of DNA-templated transcription, elongation(GO:0032785)
1.4 7.1 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
1.4 7.0 GO:0070814 hydrogen sulfide metabolic process(GO:0070813) hydrogen sulfide biosynthetic process(GO:0070814)
1.3 3.9 GO:0000028 ribosomal small subunit assembly(GO:0000028)
1.3 7.7 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
1.3 3.8 GO:0006567 threonine catabolic process(GO:0006567)
1.3 1.3 GO:0032447 protein urmylation(GO:0032447)
1.2 4.9 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
1.2 4.9 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
1.1 4.5 GO:1900434 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
1.1 6.6 GO:0006491 N-glycan processing(GO:0006491)
1.1 3.3 GO:0046416 D-amino acid metabolic process(GO:0046416)
1.1 6.5 GO:0070941 eisosome assembly(GO:0070941)
1.1 2.2 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
1.0 106.2 GO:0002181 cytoplasmic translation(GO:0002181)
1.0 20.7 GO:0002098 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.9 6.5 GO:0042938 dipeptide transport(GO:0042938)
0.9 3.7 GO:0006657 CDP-choline pathway(GO:0006657)
0.9 3.6 GO:0042710 biofilm formation(GO:0042710)
0.9 0.9 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.8 5.9 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
0.8 4.8 GO:0071267 L-methionine biosynthetic process from methylthioadenosine(GO:0019509) amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
0.8 5.4 GO:0006855 drug transmembrane transport(GO:0006855)
0.7 3.0 GO:0071326 cellular glucose homeostasis(GO:0001678) carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255) carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.7 7.3 GO:0006415 translational termination(GO:0006415)
0.7 3.6 GO:0034503 protein localization to nucleolar rDNA repeats(GO:0034503)
0.7 7.0 GO:0051231 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231)
0.7 2.8 GO:0048313 Golgi inheritance(GO:0048313)
0.7 2.0 GO:0042255 ribosome assembly(GO:0042255)
0.6 1.9 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.6 4.4 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.6 1.3 GO:0034472 snRNA processing(GO:0016180) snRNA 3'-end processing(GO:0034472) nuclear polyadenylation-dependent mRNA catabolic process(GO:0071042) polyadenylation-dependent mRNA catabolic process(GO:0071047)
0.6 1.2 GO:0071038 tRNA catabolic process(GO:0016078) nuclear polyadenylation-dependent tRNA catabolic process(GO:0071038)
0.6 3.1 GO:0042435 tryptophan biosynthetic process(GO:0000162) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
0.6 2.4 GO:0006596 polyamine biosynthetic process(GO:0006596)
0.6 2.4 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.6 5.8 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.6 2.3 GO:0048279 vesicle fusion with endoplasmic reticulum(GO:0048279)
0.6 0.6 GO:0006528 asparagine metabolic process(GO:0006528)
0.6 1.7 GO:0043171 peptide catabolic process(GO:0043171)
0.6 1.7 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.6 1.1 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
0.6 2.2 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.6 1.7 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.6 4.5 GO:0016559 peroxisome fission(GO:0016559)
0.6 15.5 GO:0006414 translational elongation(GO:0006414)
0.5 2.1 GO:0009240 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490)
0.5 1.1 GO:0044209 AMP salvage(GO:0044209)
0.5 1.6 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.5 2.1 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.5 3.6 GO:0046501 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.5 3.0 GO:0035437 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.5 4.0 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.5 5.4 GO:0006446 regulation of translational initiation(GO:0006446)
0.5 0.5 GO:0032261 purine nucleotide salvage(GO:0032261)
0.4 2.2 GO:0055074 cellular calcium ion homeostasis(GO:0006874) calcium ion homeostasis(GO:0055074)
0.4 2.2 GO:0032988 ribonucleoprotein complex disassembly(GO:0032988)
0.4 2.1 GO:0046655 folic acid metabolic process(GO:0046655) folic acid biosynthetic process(GO:0046656)
0.4 2.1 GO:0070898 RNA polymerase III transcriptional preinitiation complex assembly(GO:0070898)
0.4 0.8 GO:0007000 nucleolus organization(GO:0007000)
0.4 1.2 GO:0070827 chromatin maintenance(GO:0070827)
0.4 1.6 GO:0006566 threonine metabolic process(GO:0006566) threonine biosynthetic process(GO:0009088)
0.4 13.8 GO:0008033 tRNA processing(GO:0008033)
0.4 1.6 GO:0030030 cell projection organization(GO:0030030) cell projection assembly(GO:0030031)
0.4 4.0 GO:0001402 signal transduction involved in filamentous growth(GO:0001402)
0.4 1.2 GO:0033241 regulation of cellular amine catabolic process(GO:0033241)
0.4 1.2 GO:0038032 termination of signal transduction(GO:0023021) termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.4 1.1 GO:0006114 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.4 7.5 GO:0046785 microtubule nucleation(GO:0007020) microtubule polymerization(GO:0046785)
0.4 0.7 GO:0042992 negative regulation of transcription factor import into nucleus(GO:0042992)
0.4 2.5 GO:0006641 neutral lipid metabolic process(GO:0006638) acylglycerol metabolic process(GO:0006639) triglyceride metabolic process(GO:0006641)
0.4 4.3 GO:0030011 maintenance of cell polarity(GO:0030011)
0.4 2.5 GO:0006672 ceramide metabolic process(GO:0006672) ceramide biosynthetic process(GO:0046513)
0.4 2.8 GO:0015833 peptide transport(GO:0015833)
0.4 1.4 GO:0042559 folic acid-containing compound biosynthetic process(GO:0009396) pteridine-containing compound biosynthetic process(GO:0042559)
0.4 1.8 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.3 2.0 GO:0009231 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.3 0.3 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.3 8.1 GO:0016129 ergosterol biosynthetic process(GO:0006696) phytosteroid biosynthetic process(GO:0016129) cellular alcohol biosynthetic process(GO:0044108) cellular lipid biosynthetic process(GO:0097384)
0.3 1.0 GO:0090399 replicative senescence(GO:0090399)
0.3 0.3 GO:0048211 Golgi vesicle docking(GO:0048211)
0.3 3.2 GO:0071966 fungal-type cell wall chitin biosynthetic process(GO:0034221) fungal-type cell wall polysaccharide biosynthetic process(GO:0051278) fungal-type cell wall polysaccharide metabolic process(GO:0071966)
0.3 26.2 GO:0006913 nucleocytoplasmic transport(GO:0006913)
0.3 4.0 GO:0000011 vacuole inheritance(GO:0000011)
0.3 0.9 GO:0009097 isoleucine biosynthetic process(GO:0009097)
0.3 1.2 GO:0055129 L-proline biosynthetic process(GO:0055129)
0.3 5.4 GO:0016575 histone deacetylation(GO:0016575)
0.3 1.8 GO:0043457 regulation of cellular respiration(GO:0043457)
0.3 0.5 GO:0046184 pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823) aldehyde biosynthetic process(GO:0046184)
0.3 4.9 GO:0006334 nucleosome assembly(GO:0006334)
0.3 1.0 GO:0031507 heterochromatin assembly(GO:0031507)
0.3 1.5 GO:0006768 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.2 2.5 GO:0009303 rRNA transcription(GO:0009303)
0.2 2.2 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.2 1.9 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.2 2.2 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
0.2 0.2 GO:0006952 defense response(GO:0006952)
0.2 1.2 GO:0070124 mitochondrial translational initiation(GO:0070124)
0.2 1.1 GO:0006032 aminoglycan catabolic process(GO:0006026) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.2 1.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.2 0.4 GO:0033262 regulation of nuclear cell cycle DNA replication(GO:0033262)
0.2 1.8 GO:0008615 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.2 5.3 GO:0006885 regulation of pH(GO:0006885)
0.2 1.7 GO:0006816 calcium ion transport(GO:0006816)
0.2 5.8 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.2 0.8 GO:0006734 NADH metabolic process(GO:0006734)
0.2 1.8 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.2 0.4 GO:0016578 histone deubiquitination(GO:0016578)
0.2 1.8 GO:0008298 intracellular mRNA localization(GO:0008298)
0.2 3.4 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.2 1.3 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.2 2.3 GO:0007009 plasma membrane organization(GO:0007009)
0.2 0.7 GO:0006999 nuclear pore organization(GO:0006999)
0.2 2.1 GO:0007120 axial cellular bud site selection(GO:0007120)
0.2 2.7 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.2 0.5 GO:0006037 cell wall chitin metabolic process(GO:0006037)
0.2 4.7 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.2 0.6 GO:0007535 donor selection(GO:0007535)
0.2 0.6 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.2 0.9 GO:0046015 regulation of transcription by glucose(GO:0046015)
0.1 0.3 GO:2000756 regulation of histone acetylation(GO:0035065) positive regulation of histone acetylation(GO:0035066) regulation of protein acetylation(GO:1901983) positive regulation of protein acetylation(GO:1901985) regulation of peptidyl-lysine acetylation(GO:2000756) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.1 0.9 GO:0042538 hyperosmotic salinity response(GO:0042538)
0.1 1.3 GO:0007121 bipolar cellular bud site selection(GO:0007121)
0.1 0.5 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.1 0.7 GO:0000087 mitotic M phase(GO:0000087) M phase(GO:0000279)
0.1 1.1 GO:0052803 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.1 1.9 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 0.5 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.1 0.9 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.1 0.9 GO:0006797 polyphosphate metabolic process(GO:0006797)
0.1 2.0 GO:0051668 localization within membrane(GO:0051668)
0.1 0.9 GO:0046351 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.1 1.8 GO:0072384 establishment of localization by movement along microtubule(GO:0010970) nuclear migration along microtubule(GO:0030473) organelle transport along microtubule(GO:0072384)
0.1 0.6 GO:0016584 nucleosome positioning(GO:0016584)
0.1 0.8 GO:0051648 vesicle targeting(GO:0006903) vesicle localization(GO:0051648) establishment of vesicle localization(GO:0051650)
0.1 0.2 GO:0045764 positive regulation of cellular amino acid metabolic process(GO:0045764)
0.1 2.8 GO:0045324 late endosome to vacuole transport(GO:0045324)
0.1 0.3 GO:0001015 snoRNA transcription from an RNA polymerase II promoter(GO:0001015)
0.1 0.3 GO:1901977 regulation of cell cycle checkpoint(GO:1901976) negative regulation of cell cycle checkpoint(GO:1901977) regulation of DNA damage checkpoint(GO:2000001) negative regulation of DNA damage checkpoint(GO:2000002) negative regulation of response to DNA damage stimulus(GO:2001021)
0.1 1.0 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.1 0.2 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781) UDP-glucose transport(GO:0015786)
0.1 0.5 GO:0000707 meiotic DNA recombinase assembly(GO:0000707) DNA recombinase assembly(GO:0000730)
0.1 0.1 GO:0043966 histone H3 acetylation(GO:0043966) histone H3-K9 acetylation(GO:0043970) histone H3-K14 acetylation(GO:0044154) histone H3-K9 modification(GO:0061647)
0.1 1.5 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.1 0.6 GO:0032042 mitochondrial DNA metabolic process(GO:0032042)
0.1 0.3 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.1 0.7 GO:0016233 telomere capping(GO:0016233)
0.1 0.4 GO:0090158 regulation of phosphatidylinositol dephosphorylation(GO:0060304) endoplasmic reticulum membrane organization(GO:0090158)
0.1 0.9 GO:0016925 protein sumoylation(GO:0016925)
0.1 0.6 GO:0007323 peptide pheromone maturation(GO:0007323)
0.1 0.4 GO:0000755 cytogamy(GO:0000755)
0.1 0.4 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.1 0.1 GO:0016320 endoplasmic reticulum membrane fusion(GO:0016320) ribophagy(GO:0034517) mitotic spindle disassembly(GO:0051228) spindle disassembly(GO:0051230)
0.1 0.6 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.1 0.9 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.1 1.4 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.1 0.7 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.1 1.2 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.1 1.0 GO:0006915 apoptotic process(GO:0006915) cell death(GO:0008219) programmed cell death(GO:0012501)
0.1 0.5 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1 1.6 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.1 0.2 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.0 GO:0030307 positive regulation of cell growth(GO:0030307) positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter(GO:1900461) positive regulation of pseudohyphal growth(GO:2000222)
0.0 0.4 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.0 0.3 GO:0051177 synaptonemal complex assembly(GO:0007130) meiotic sister chromatid cohesion(GO:0051177) synaptonemal complex organization(GO:0070193)
0.0 0.1 GO:0015939 pantothenate metabolic process(GO:0015939) pantothenate biosynthetic process(GO:0015940)
0.0 0.2 GO:0000733 DNA strand renaturation(GO:0000733)
0.0 0.3 GO:0006614 cotranslational protein targeting to membrane(GO:0006613) SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.1 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.0 0.4 GO:0071173 mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173)
0.0 0.6 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.4 GO:0044848 biological phase(GO:0044848)
0.0 0.8 GO:0070897 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123) DNA-templated transcriptional preinitiation complex assembly(GO:0070897)
0.0 0.0 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117) positive regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0090282)
0.0 0.6 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.1 GO:0009306 protein secretion(GO:0009306)
0.0 0.1 GO:0070071 proton-transporting two-sector ATPase complex assembly(GO:0070071)
0.0 0.2 GO:0051666 actin cortical patch localization(GO:0051666)
0.0 0.0 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.0 GO:0006784 heme a biosynthetic process(GO:0006784) heme a metabolic process(GO:0046160)
0.0 0.1 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.0 0.1 GO:0030472 mitotic spindle organization in nucleus(GO:0030472)
0.0 0.1 GO:0009249 protein lipoylation(GO:0009249)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
7.6 22.8 GO:0070545 PeBoW complex(GO:0070545)
5.3 26.7 GO:0030689 Noc complex(GO:0030689)
5.2 72.3 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
5.1 20.6 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
4.8 14.4 GO:0032299 ribonuclease H2 complex(GO:0032299)
4.6 18.5 GO:0031428 box C/D snoRNP complex(GO:0031428)
4.6 46.0 GO:0030688 preribosome, small subunit precursor(GO:0030688)
4.4 26.6 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
4.3 178.8 GO:0030687 preribosome, large subunit precursor(GO:0030687)
4.2 12.7 GO:0034457 Mpp10 complex(GO:0034457)
3.7 21.9 GO:0034455 t-UTP complex(GO:0034455)
3.4 75.0 GO:0032040 small-subunit processome(GO:0032040)
3.2 15.9 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
2.8 11.3 GO:0070860 RNA polymerase I core factor complex(GO:0070860)
2.7 8.1 GO:0097344 Rix1 complex(GO:0097344)
2.4 9.7 GO:0042788 polysomal ribosome(GO:0042788)
2.4 11.9 GO:0043527 tRNA methyltransferase complex(GO:0043527)
2.3 6.8 GO:0008275 gamma-tubulin small complex, spindle pole body(GO:0000928) gamma-tubulin complex(GO:0000930) gamma-tubulin small complex(GO:0008275)
2.2 22.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
2.1 8.6 GO:0034448 EGO complex(GO:0034448)
2.1 82.5 GO:0030684 preribosome(GO:0030684)
2.0 5.9 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
2.0 260.2 GO:0005730 nucleolus(GO:0005730)
1.5 9.2 GO:0033588 Elongator holoenzyme complex(GO:0033588)
1.4 102.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
1.3 5.4 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
1.3 5.3 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
1.2 9.9 GO:0031414 N-terminal protein acetyltransferase complex(GO:0031414)
1.1 5.4 GO:0030478 actin cap(GO:0030478)
1.1 5.3 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
1.0 2.9 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.9 3.6 GO:0032160 septin filament array(GO:0032160)
0.9 2.6 GO:0035649 Nrd1 complex(GO:0035649)
0.8 3.4 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.8 2.5 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.8 2.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.8 2.4 GO:0051286 cell tip(GO:0051286)
0.8 4.6 GO:0005880 nuclear microtubule(GO:0005880)
0.7 2.1 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.7 2.1 GO:0043529 GET complex(GO:0043529)
0.7 2.0 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.6 1.9 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
0.6 2.5 GO:0033597 mitotic checkpoint complex(GO:0033597)
0.6 22.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.6 1.9 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.6 6.8 GO:0005940 septin ring(GO:0005940)
0.6 8.3 GO:0022626 cytosolic ribosome(GO:0022626)
0.6 1.7 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.5 4.4 GO:0042597 periplasmic space(GO:0042597)
0.5 3.7 GO:0051233 spindle midzone(GO:0051233)
0.5 3.6 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.5 0.5 GO:0005688 U6 snRNP(GO:0005688)
0.5 5.9 GO:0005637 nuclear inner membrane(GO:0005637)
0.5 2.9 GO:0032126 eisosome(GO:0032126)
0.5 2.4 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.5 1.4 GO:0005845 mRNA cap binding complex(GO:0005845)
0.4 1.8 GO:0005641 nuclear envelope lumen(GO:0005641)
0.4 1.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.4 2.2 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.4 3.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.4 2.0 GO:0016272 prefoldin complex(GO:0016272)
0.4 2.2 GO:0070772 PAS complex(GO:0070772)
0.4 1.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.3 7.6 GO:0005844 polysome(GO:0005844)
0.3 1.0 GO:0032301 MutSalpha complex(GO:0032301)
0.3 4.7 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.3 2.3 GO:0000346 transcription export complex(GO:0000346)
0.3 7.3 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.3 6.7 GO:0031298 replication fork protection complex(GO:0031298)
0.3 0.8 GO:0005662 DNA replication factor A complex(GO:0005662)
0.3 1.1 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.3 1.0 GO:0008623 CHRAC(GO:0008623)
0.2 0.5 GO:0030428 cell septum(GO:0030428)
0.2 0.9 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.2 1.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.2 0.2 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.2 2.6 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.2 0.8 GO:0005797 Golgi medial cisterna(GO:0005797)
0.2 0.8 GO:0000818 MIS12/MIND type complex(GO:0000444) nuclear MIS12/MIND complex(GO:0000818)
0.2 2.3 GO:0005686 U2 snRNP(GO:0005686)
0.2 2.7 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.2 3.7 GO:0070847 core mediator complex(GO:0070847)
0.2 1.3 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.2 1.7 GO:0000243 commitment complex(GO:0000243)
0.2 0.5 GO:0000137 Golgi cis cisterna(GO:0000137)
0.1 0.9 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 5.2 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 2.5 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.1 1.1 GO:0000792 heterochromatin(GO:0000792)
0.1 0.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.1 1.2 GO:0000142 cellular bud neck contractile ring(GO:0000142)
0.1 0.8 GO:0016459 myosin complex(GO:0016459)
0.1 2.5 GO:0031201 SNARE complex(GO:0031201)
0.1 0.8 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 12.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 0.7 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.1 0.4 GO:0071819 DUBm complex(GO:0071819)
0.1 1.5 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 2.9 GO:0044445 cytosolic part(GO:0044445)
0.1 1.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 1.1 GO:0034399 nuclear periphery(GO:0034399)
0.1 0.6 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.1 2.3 GO:0005874 microtubule(GO:0005874)
0.1 0.3 GO:0034990 mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990)
0.1 0.5 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 3.3 GO:0005643 nuclear pore(GO:0005643)
0.1 7.2 GO:0005840 ribosome(GO:0005840)
0.1 0.4 GO:0000835 cytoplasmic ubiquitin ligase complex(GO:0000153) ER ubiquitin ligase complex(GO:0000835)
0.1 0.5 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 0.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 0.7 GO:0016586 RSC complex(GO:0016586)
0.0 0.6 GO:0016514 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.0 0.5 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 0.6 GO:0036452 ESCRT complex(GO:0036452)
0.0 0.1 GO:0070823 HDA1 complex(GO:0070823)
0.0 0.1 GO:0097196 Shu complex(GO:0097196)
0.0 0.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.8 GO:0005811 lipid particle(GO:0005811)
0.0 0.2 GO:0034967 Set3 complex(GO:0034967)
0.0 0.0 GO:0031010 ISWI-type complex(GO:0031010)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.9 6.9 GO:0033592 RNA strand annealing activity(GO:0033592) annealing activity(GO:0097617)
6.4 19.2 GO:0008097 5S rRNA binding(GO:0008097)
5.2 72.3 GO:0001054 RNA polymerase I activity(GO:0001054)
5.1 15.2 GO:0019003 GDP binding(GO:0019003)
4.9 29.6 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
4.8 14.4 GO:0003938 IMP dehydrogenase activity(GO:0003938)
4.7 93.1 GO:0030515 snoRNA binding(GO:0030515)
4.3 12.9 GO:0070568 guanylyltransferase activity(GO:0070568)
3.6 14.5 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
3.6 14.4 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
3.6 10.7 GO:0016433 rRNA (adenine) methyltransferase activity(GO:0016433)
3.6 10.7 GO:0016273 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
3.1 9.3 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
2.9 8.8 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
2.9 17.1 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
2.8 11.1 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
2.8 13.8 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
2.8 11.0 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
2.5 76.7 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
2.4 4.8 GO:0042134 rRNA primary transcript binding(GO:0042134)
2.3 7.0 GO:0043023 ribosomal large subunit binding(GO:0043023)
2.2 22.4 GO:0001056 RNA polymerase III activity(GO:0001056)
2.1 8.6 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
2.1 2.1 GO:1904680 peptide-transporting ATPase activity(GO:0015440) peptide transmembrane transporter activity(GO:1904680)
2.0 12.1 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
2.0 8.1 GO:0016841 ammonia-lyase activity(GO:0016841)
1.9 5.8 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
1.8 5.4 GO:0072341 modified amino acid binding(GO:0072341)
1.8 5.3 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
1.7 5.1 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
1.7 6.7 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
1.7 8.3 GO:0008186 RNA-dependent ATPase activity(GO:0008186)
1.7 8.3 GO:0003725 double-stranded RNA binding(GO:0003725)
1.6 6.4 GO:0019206 nucleoside kinase activity(GO:0019206)
1.6 11.1 GO:0016778 diphosphotransferase activity(GO:0016778)
1.5 4.6 GO:0004326 tetrahydrofolylpolyglutamate synthase activity(GO:0004326)
1.5 4.6 GO:0010521 telomerase inhibitor activity(GO:0010521)
1.5 13.7 GO:0009982 pseudouridine synthase activity(GO:0009982)
1.5 4.4 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
1.5 8.8 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
1.4 54.9 GO:0019843 rRNA binding(GO:0019843)
1.4 4.3 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
1.4 13.8 GO:0019239 deaminase activity(GO:0019239)
1.3 5.4 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
1.3 4.0 GO:0016882 cyclo-ligase activity(GO:0016882)
1.3 2.7 GO:0001082 transcription factor activity, RNA polymerase I transcription factor binding(GO:0001082) RNA polymerase I transcription factor binding(GO:0001179)
1.3 19.9 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen(GO:0016705)
1.3 8.0 GO:0015198 oligopeptide transporter activity(GO:0015198)
1.3 3.9 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
1.3 1.3 GO:0004602 glutathione peroxidase activity(GO:0004602)
1.2 4.9 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
1.2 4.8 GO:0004338 glucan exo-1,3-beta-glucosidase activity(GO:0004338)
1.2 7.2 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
1.2 1.2 GO:0032296 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
1.1 19.3 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
1.1 3.4 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825)
1.1 5.6 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
1.1 13.4 GO:0008175 tRNA methyltransferase activity(GO:0008175)
1.1 3.2 GO:0070336 flap-structured DNA binding(GO:0070336)
1.1 9.6 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
1.1 3.2 GO:0004100 chitin synthase activity(GO:0004100)
1.0 5.2 GO:0008443 phosphofructokinase activity(GO:0008443)
1.0 2.9 GO:0051010 microtubule plus-end binding(GO:0051010)
0.9 8.0 GO:0008173 RNA methyltransferase activity(GO:0008173)
0.8 148.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.8 2.5 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.8 7.9 GO:0003746 translation elongation factor activity(GO:0003746)
0.8 3.9 GO:0070403 NAD+ binding(GO:0070403)
0.8 10.7 GO:0001671 ATPase activator activity(GO:0001671)
0.8 60.8 GO:0005525 GTP binding(GO:0005525) guanyl nucleotide binding(GO:0019001) guanyl ribonucleotide binding(GO:0032561)
0.7 5.9 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.7 2.1 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.7 3.5 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.7 5.4 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.7 6.6 GO:0019205 nucleobase-containing compound kinase activity(GO:0019205)
0.6 8.3 GO:0045182 translation regulator activity(GO:0045182)
0.6 3.2 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.6 0.6 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.6 8.1 GO:0000049 tRNA binding(GO:0000049)
0.6 22.4 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.6 2.5 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.6 2.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.6 3.0 GO:0004707 MAP kinase activity(GO:0004707)
0.6 141.6 GO:0003723 RNA binding(GO:0003723)
0.6 5.6 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.5 2.7 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.5 2.6 GO:0008198 ferrous iron binding(GO:0008198)
0.5 5.1 GO:0005516 calmodulin binding(GO:0005516)
0.5 1.0 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.5 8.4 GO:0042803 protein homodimerization activity(GO:0042803)
0.5 1.9 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.5 1.4 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.5 6.4 GO:0005506 iron ion binding(GO:0005506)
0.4 2.7 GO:0004529 exodeoxyribonuclease activity(GO:0004529)
0.4 1.3 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.4 1.3 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.4 1.3 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.4 1.7 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.4 4.5 GO:0001083 transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083)
0.4 4.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.4 6.4 GO:0004521 endoribonuclease activity(GO:0004521)
0.4 8.0 GO:0016836 hydro-lyase activity(GO:0016836)
0.3 1.7 GO:0017048 Rho GTPase binding(GO:0017048)
0.3 9.2 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.3 1.3 GO:0060590 ATPase regulator activity(GO:0060590)
0.3 2.5 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.3 3.3 GO:0000182 rDNA binding(GO:0000182)
0.3 2.3 GO:0010181 FMN binding(GO:0010181)
0.3 3.1 GO:0043495 protein anchor(GO:0043495)
0.3 4.9 GO:0008017 microtubule binding(GO:0008017)
0.3 1.0 GO:0008252 nucleotidase activity(GO:0008252)
0.3 6.0 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.3 2.0 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.2 1.0 GO:0008172 S-methyltransferase activity(GO:0008172)
0.2 2.4 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.2 0.5 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.2 0.7 GO:0042973 glucan endo-1,3-beta-D-glucosidase activity(GO:0042973)
0.2 0.9 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.2 1.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.2 3.1 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.2 1.1 GO:0070546 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.2 2.0 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.2 0.8 GO:0001055 RNA polymerase II activity(GO:0001055)
0.2 0.8 GO:0009378 four-way junction helicase activity(GO:0009378)
0.2 0.6 GO:0005262 calcium channel activity(GO:0005262)
0.2 0.8 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 1.7 GO:0005496 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.2 0.8 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.2 1.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 1.9 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.2 1.1 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.2 0.5 GO:0016408 C-acyltransferase activity(GO:0016408)
0.2 0.2 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.2 0.5 GO:0019901 protein kinase binding(GO:0019901)
0.2 4.6 GO:0046982 protein heterodimerization activity(GO:0046982)
0.2 0.8 GO:0019238 cyclohydrolase activity(GO:0019238)
0.2 2.6 GO:0051536 iron-sulfur cluster binding(GO:0051536) metal cluster binding(GO:0051540)
0.2 0.6 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.2 0.6 GO:0051213 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) dioxygenase activity(GO:0051213)
0.2 0.5 GO:0008144 drug binding(GO:0008144)
0.1 0.9 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.1 1.0 GO:0051920 thioredoxin peroxidase activity(GO:0008379) peroxiredoxin activity(GO:0051920)
0.1 0.6 GO:0017022 myosin binding(GO:0017022)
0.1 3.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 1.5 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.2 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.1 2.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 0.7 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.1 0.5 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 0.4 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.1 7.1 GO:0003682 chromatin binding(GO:0003682)
0.1 2.1 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 0.2 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.1 0.5 GO:1901618 organic hydroxy compound transmembrane transporter activity(GO:1901618)
0.1 0.5 GO:0000009 alpha-1,6-mannosyltransferase activity(GO:0000009)
0.1 0.2 GO:0001128 RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly(GO:0001128)
0.1 2.2 GO:0043130 ubiquitin binding(GO:0043130)
0.1 0.9 GO:0015926 glucosidase activity(GO:0015926)
0.1 1.3 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity(GO:0008757)
0.1 0.7 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 0.4 GO:0043022 ribosome binding(GO:0043022)
0.0 1.1 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.2 GO:0042123 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.0 0.1 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139)
0.0 0.2 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.0 0.3 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.1 GO:0031072 heat shock protein binding(GO:0031072)
0.0 0.6 GO:0005048 signal sequence binding(GO:0005048)
0.0 0.3 GO:0046983 protein dimerization activity(GO:0046983)
0.0 0.3 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.2 GO:0031386 protein tag(GO:0031386)
0.0 1.0 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 1.0 GO:0060589 nucleoside-triphosphatase regulator activity(GO:0060589)
0.0 0.3 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.1 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 0.1 GO:0008525 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.0 0.2 GO:0005509 calcium ion binding(GO:0005509)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 9.8 NABA CORE MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
2.4 2.4 PID VEGFR1 PATHWAY VEGFR1 specific signals
1.4 5.6 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
1.2 3.6 PID LKB1 PATHWAY LKB1 signaling events
0.6 2.5 PID P73PATHWAY p73 transcription factor network
0.5 2.1 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.4 1.1 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.4 1.1 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.2 0.9 PID PLK1 PATHWAY PLK1 signaling events
0.1 1.2 NABA MATRISOME Ensemble of genes encoding extracellular matrix and extracellular matrix-associated proteins
0.1 0.4 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.1 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 17.7 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
2.0 8.0 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
1.7 13.6 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
1.7 11.6 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
1.5 3.1 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
1.3 3.8 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
1.2 19.6 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.7 5.6 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.4 1.3 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.4 2.5 REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.4 0.4 REACTOME DEADENYLATION DEPENDENT MRNA DECAY Genes involved in Deadenylation-dependent mRNA decay
0.4 2.4 REACTOME AXON GUIDANCE Genes involved in Axon guidance
0.3 1.0 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.2 0.7 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.1 1.0 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1 1.7 REACTOME TRANSCRIPTION Genes involved in Transcription
0.1 0.8 REACTOME DNA STRAND ELONGATION Genes involved in DNA strand elongation
0.1 0.3 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 0.3 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 0.5 REACTOME SIGNALING BY GPCR Genes involved in Signaling by GPCR
0.1 0.3 REACTOME APOPTOSIS Genes involved in Apoptosis