Results for PBF2
Z-value: 2.50
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Transcription factors associated with PBF2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
DOT6
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S000000890 | Protein involved in rRNA and ribosome biogenesis |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YFR055W Show fit | 35.49 |
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner |
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| YFR056C Show fit | 30.52 |
Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W |
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| YKR092C Show fit | 24.83 |
Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140 |
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| YER074W Show fit | 18.72 |
Protein component of the small (40S) ribosomal subunit; identical to Rps24Bp and has similarity to rat S24 ribosomal protein |
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| YER073W Show fit | 18.37 |
Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed |
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| YOR101W Show fit | 17.22 |
GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes |
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| YOR096W Show fit | 16.43 |
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins |
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| YPR148C Show fit | 15.11 |
Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern |
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| YNL178W Show fit | 14.89 |
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins |
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| YIR021W Show fit | 14.08 |
Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA |
Network of associatons between targets according to the STRING database.
First level regulatory network of PBF2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 172.7 | GO:0006364 | rRNA processing(GO:0006364) |
| 3.4 | 162.1 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 2.5 | 144.7 | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) |
| 3.6 | 119.4 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 3.8 | 106.5 | GO:0000480 | endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480) |
| 1.0 | 106.2 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 3.2 | 57.5 | GO:0042790 | transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790) |
| 2.3 | 55.5 | GO:0000054 | ribosomal subunit export from nucleus(GO:0000054) ribosome localization(GO:0033750) establishment of ribosome localization(GO:0033753) |
| 2.7 | 49.4 | GO:0009304 | tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797) |
| 2.3 | 40.8 | GO:0030488 | tRNA methylation(GO:0030488) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 260.2 | GO:0005730 | nucleolus(GO:0005730) |
| 4.3 | 178.8 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 1.4 | 102.0 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 2.1 | 82.5 | GO:0030684 | preribosome(GO:0030684) |
| 3.4 | 75.0 | GO:0032040 | small-subunit processome(GO:0032040) |
| 5.2 | 72.3 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 4.6 | 46.0 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 5.3 | 26.7 | GO:0030689 | Noc complex(GO:0030689) |
| 4.4 | 26.6 | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome(GO:0034388) |
| 7.6 | 22.8 | GO:0070545 | PeBoW complex(GO:0070545) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 148.7 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.6 | 141.6 | GO:0003723 | RNA binding(GO:0003723) |
| 4.7 | 93.1 | GO:0030515 | snoRNA binding(GO:0030515) |
| 2.5 | 76.7 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 5.2 | 72.3 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 0.8 | 60.8 | GO:0005525 | GTP binding(GO:0005525) guanyl nucleotide binding(GO:0019001) guanyl ribonucleotide binding(GO:0032561) |
| 1.4 | 54.9 | GO:0019843 | rRNA binding(GO:0019843) |
| 4.9 | 29.6 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 2.2 | 22.4 | GO:0001056 | RNA polymerase III activity(GO:0001056) |
| 0.6 | 22.4 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 9.8 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 1.4 | 5.6 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 1.2 | 3.6 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.6 | 2.5 | PID P73PATHWAY | p73 transcription factor network |
| 2.4 | 2.4 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.5 | 2.1 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 1.2 | NABA MATRISOME | Ensemble of genes encoding extracellular matrix and extracellular matrix-associated proteins |
| 0.4 | 1.1 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.4 | 1.1 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.2 | 0.9 | PID PLK1 PATHWAY | PLK1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 19.6 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 2.2 | 17.7 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 1.7 | 13.6 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 1.7 | 11.6 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 2.0 | 8.0 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.7 | 5.6 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 1.3 | 3.8 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 1.5 | 3.1 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.4 | 2.5 | REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A | Genes involved in APC-Cdc20 mediated degradation of Nek2A |
| 0.4 | 2.4 | REACTOME AXON GUIDANCE | Genes involved in Axon guidance |