Results for PBF1
Z-value: 2.90
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Transcription factors associated with PBF1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
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TOD6
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S000000150 | PAC motif binding protein involved in rRNA and ribosome biogenesis |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YFR055W Show fit | 27.84 |
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner |
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| YOR101W Show fit | 25.80 |
GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes |
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| YFR056C Show fit | 24.05 |
Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W |
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| YER073W Show fit | 21.09 |
Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed |
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| YOR096W Show fit | 19.06 |
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins |
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| YKR092C Show fit | 18.81 |
Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140 |
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| YOR340C Show fit | 17.13 |
RNA polymerase I subunit A43 |
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| YGR251W Show fit | 16.95 |
Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene |
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| YIR021W Show fit | 15.42 |
Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA |
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| YDL148C Show fit | 15.30 |
Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA |
Network of associatons between targets according to the STRING database.
First level regulatory network of PBF1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.0 | 312.7 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 2.5 | 219.1 | GO:0006364 | rRNA processing(GO:0006364) |
| 2.6 | 143.0 | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) |
| 4.7 | 132.4 | GO:0000480 | endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480) |
| 1.1 | 113.9 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 2.7 | 59.3 | GO:0033750 | ribosomal subunit export from nucleus(GO:0000054) ribosome localization(GO:0033750) establishment of ribosome localization(GO:0033753) |
| 3.9 | 55.3 | GO:0042790 | transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790) |
| 3.0 | 54.6 | GO:0030488 | tRNA methylation(GO:0030488) |
| 3.0 | 53.7 | GO:0009304 | tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797) |
| 6.8 | 34.2 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 279.1 | GO:0005730 | nucleolus(GO:0005730) |
| 5.0 | 221.0 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 1.3 | 98.1 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 2.3 | 88.3 | GO:0030684 | preribosome(GO:0030684) |
| 6.0 | 84.0 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 3.6 | 80.2 | GO:0032040 | small-subunit processome(GO:0032040) |
| 4.8 | 38.4 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 7.3 | 36.3 | GO:0030689 | Noc complex(GO:0030689) |
| 0.9 | 32.4 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 5.1 | 30.7 | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome(GO:0034388) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 187.7 | GO:0003723 | RNA binding(GO:0003723) |
| 0.8 | 140.7 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 5.6 | 111.7 | GO:0030515 | snoRNA binding(GO:0030515) |
| 2.9 | 88.6 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 6.0 | 84.0 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 0.9 | 75.2 | GO:0032561 | GTP binding(GO:0005525) guanyl nucleotide binding(GO:0019001) guanyl ribonucleotide binding(GO:0032561) |
| 1.4 | 52.1 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.7 | 26.2 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
| 2.4 | 24.3 | GO:0001056 | RNA polymerase III activity(GO:0001056) |
| 1.4 | 23.4 | GO:0016763 | transferase activity, transferring pentosyl groups(GO:0016763) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 6.3 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 1.5 | 5.9 | PID P73PATHWAY | p73 transcription factor network |
| 1.4 | 5.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 1.5 | 4.6 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.6 | 2.5 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 1.5 | 1.5 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.4 | 1.3 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.3 | 1.1 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.3 | 0.7 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.2 | 0.4 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 19.7 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 2.0 | 16.1 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 1.8 | 14.6 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 2.0 | 14.0 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 2.8 | 11.1 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 1.0 | 5.9 | REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS | Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins |
| 0.7 | 5.8 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 1.7 | 5.0 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.3 | 3.6 | REACTOME TRANSCRIPTION | Genes involved in Transcription |
| 0.5 | 2.5 | REACTOME APOPTOSIS | Genes involved in Apoptosis |