Navigation
Downloads

Results for NHP6A

Z-value: 0.41

Motif logo

logo of

Transcription factors associated with NHP6A

Gene Symbol Gene ID Gene Info
NHP6A
S000006256 High-mobility group (HMG) protein, binds to and remodels nucleosomes

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NHP6AYPR052C-0.115.9e-01Click!

Activity profile of NHP6A motif

Sorted Z-values of NHP6A motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YGL177W 1.06 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKR034W 0.91
DAL80
Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Deh1p
YPR169W-A 0.84 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps two other dubious ORFs: YPR170C and YPR170W-B
YDR043C 0.73
NRG1
Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YGR161C 0.70
RTS3
Putative component of the protein phosphatase type 2A complex
YLR307C-A 0.69 Putative protein of unknown function
YJR094C 0.63
IME1
Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
YGR039W 0.58 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722
YJL149W 0.58
DAS1
Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C; null mutant suppresses dst1delta sensitivity for 6-azauracil
YJL107C 0.54 Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
YAL062W 0.54
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YMR175W 0.54
SIP18
Protein of unknown function whose expression is induced by osmotic stress
YJL150W 0.54 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL023C 0.52 Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
YDL022W 0.51
GPD1
NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p
YFL033C 0.49
RIM15
Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
YGL178W 0.48
MPT5
Member of the Puf family of RNA-binding proteins; binds to mRNAs encoding chromatin modifiers and spindle pole body components; involved in longevity, maintenance of cell wall integrity, and sensitivity to and recovery from pheromone arrest
YHR096C 0.47
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YER158W-A 0.46 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YKL065W-A 0.45 Putative protein of unknown function
YOL034W 0.45
SMC5
Structural maintenance of chromosomes (SMC) protein; essential subunit of the Mms21-Smc5-Smc6 complex; required for growth and DNA repair; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair
YIL057C 0.44 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YLR408C 0.43 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene
YDL223C 0.42
HBT1
Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
YLR300W 0.42
EXG1
Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes
YJL200C 0.42
ACO2
Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
YBR076C-A 0.42 Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene ECM8; identified by fungal homology and RT-PCR
YGR258C 0.42
RAD2
Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
YFL011W 0.41
HXT10
Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YLL046C 0.41
RNP1
Ribonucleoprotein that contains two RNA recognition motifs (RRM)
YDR085C 0.41
AFR1
Alpha-factor pheromone receptor regulator, negatively regulates pheromone receptor signaling; required for normal mating projection (shmoo) formation; required for Spa2p to recruit Mpk1p to shmoo tip during mating; interacts with Cdc12p
YER187W 0.41 Putative protein of unknown function; induced in respiratory-deficient cells
YEL065W 0.41
SIT1
Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
YKL221W 0.40
MCH2
Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YIL117C 0.39
PRM5
Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling
YLR308W 0.39
CDA2
Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
YKL105C 0.38 Putative protein of unknown function
YJL194W 0.38
CDC6
Essential ATP-binding protein required for DNA replication, component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p
YBR240C 0.37
THI2
Zinc finger protein of the Zn(II)2Cys6 type, probable transcriptional activator of thiamine biosynthetic genes
YGR286C 0.37
BIO2
Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant
YMR193C-A 0.37 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YML047W-A 0.37 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL159C 0.37 Soluble protein of unknown function; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA
YDL138W 0.36
RGT2
Plasma membrane glucose receptor, highly similar to Snf3p; both Rgt2p and Snf3p serve as transmembrane glucose sensors generating an intracellular signal that induces expression of glucose transporter (HXT) genes
YAL063C 0.36
FLO9
Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
YOL123W 0.36
HRP1
Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences
YKL188C 0.36
PXA2
Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins
YER084W 0.36 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL156C 0.35
PRM4
Pheromone-regulated protein, predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift
YML016C 0.35
PPZ1
Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
YJL007C 0.35 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR126C 0.34 Putative protein of unknown function; transcription dependent upon Azf1p
YGL089C 0.34
MF(ALPHA)2
Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2
YKR033C 0.34 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80
YJL135W 0.33 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
YCR007C 0.33 Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YKL050C 0.33 Protein of unknown function; the YKL050W protein is a target of the SCFCdc4 ubiquitin ligase complex and YKL050W transcription is regulated by Azf1p
YGR087C 0.33
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YOR178C 0.32
GAC1
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YKR032W 0.32 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR142W 0.32
PUT1
Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
YKL001C 0.31
MET14
Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
YLR049C 0.31 Putative protein of unknown function
YPR078C 0.31 Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible
YML047C 0.31
PRM6
Pheromone-regulated protein, predicted to have 2 transmembrane segments; regulated by Ste12p during mating
YBL052C 0.31
SAS3
Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; sas3 gcn5 double mutation confers lethality
YLR358C 0.30 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSC2/YLR357W
YJR005C-A 0.30 Putative protein of unknown function, originally identified as a syntenic homolog of an Ashbya gossypii gene
YLR296W 0.30 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR071W 0.30
PCL5
Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity
YBR208C 0.29
DUR1,2
Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YKL163W 0.29
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YPL062W 0.28 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation
YBR094W 0.28
PBY1
Putative tubulin tyrosine ligase associated with P-bodies
YBR056W-A 0.28 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR056C-B
YLR136C 0.28
TIS11
mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis
YMR104C 0.28
YPK2
Protein kinase with similarityto serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK
YGR067C 0.27 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YLR164W 0.27 Mitochondrial inner membrane of unknown function; similar to Tim18p and Sdh4p; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YBR292C 0.27 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
YJL106W 0.27
IME2
Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p
YIL099W 0.27
SGA1
Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
YCR001W 0.27 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR001W is not an essential gene
YER167W 0.27
BCK2
Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations
YDR258C 0.26
HSP78
Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; prevents the aggregation of misfolded matrix proteins; component of the mitochondrial proteolysis system
YGR146C 0.26 Putative protein of unknown function; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of a temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation
YIL119C 0.26
RPI1
Putative transcriptional regulator; overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation
YDL020C 0.26
RPN4
Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses
YER158C 0.26 Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p
YNL007C 0.26
SIS1
Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; not functionally redundant with Ydj1p due to due to substrate specificity; shares similarity with bacterial DnaJ proteins
YBR157C 0.26
ICS2
Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization
YNL093W 0.26
YPT53
GTPase, similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis
YPL026C 0.26
SKS1
Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YEL014C 0.26 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL179C 0.26
TOS3
Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YGR060W 0.26
ERG25
C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol
YDR528W 0.25
HLR1
Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A
YLR260W 0.25
LCB5
Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
YIL101C 0.25
XBP1
Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate
YJR047C 0.25
ANB1
Translation initiation factor eIF-5A, promotes formation of the first peptide bond; similar to and functionally redundant with Hyp2p; undergoes an essential hypusination modification; expressed under anaerobic conditions
YDL246C 0.25
SOR2
Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in fructose or mannose metabolism
YBR071W 0.25 Putative protein of unknown function; (GFP)-fusion and epitope-tagged proteins localize to the cytoplasm; mRNA expression may be regulated by the cell cycle and/or cell wall stress
YHL024W 0.25
RIM4
Putative RNA-binding protein required for the expression of early and middle sporulation genes
YPL110C 0.25
GDE1
Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes
YGL227W 0.25
VID30
Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); shifts the balance of nitrogen metabolism toward the production of glutamate; localized to the nucleus and the cytoplasm
YJL116C 0.24
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YDL003W 0.24
MCD1
Essential protein required for sister chromatid cohesion in mitosis and meiosis; subunit of the cohesin complex; expression is cell cycle regulated and peaks in S phase
YLR390W-A 0.23
CCW14
Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall
YLR431C 0.23
ATG23
Peripheral membrane protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway; cycles between the pre-autophagosome (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p
YHR095W 0.23 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL258C 0.23
THI21
Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p
YMR174C 0.23
PAI3
Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact
YGL033W 0.23
HOP2
Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
YCR040W 0.23
MATALPHA1
Transcriptional co-activator involved in regulation of mating-type-specific gene expression; targets the transcription factor Mcm1p to the promoters of alpha-specific genes; one of two genes encoded by the MATalpha mating type cassette
YAL024C 0.23
LTE1
Putative GDP/GTP exchange factor required for mitotic exit at low temperatures; acts as a guanine nucleotide exchange factor (GEF) for Tem1p, which is a key regulator of mitotic exit; physically associates with Ras2p-GTP
YHR006W 0.23
STP2
Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes
YCR099C 0.23 Putative protein of unknown function
YKL086W 0.22
SRX1
Sulfiredoxin, contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxins Tsa1p and Ahp1p that are formed upon exposure to oxidants; conserved in higher eukaryotes
YKR102W 0.22
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YDL028C 0.22
MPS1
Dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, and checkpoint protein Mad1p
YMR015C 0.22
ERG5
C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
YNL142W 0.22
MEP2
Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YIL056W 0.22
VHR1
Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations
YER109C 0.22
FLO8
Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene
YPL054W 0.22
LEE1
Zinc-finger protein of unknown function
YPR193C 0.22
HPA2
Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity
YCL048W 0.22
SPS22
Protein of unknown function, redundant with Sps2p for the organization of the beta-glucan layer of the spore wall
YOR355W 0.22
GDS1
Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YCL069W 0.21
VBA3
Permease of basic amino acids in the vacuolar membrane
YDR510W 0.21
SMT3
Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics
YCR098C 0.21
GIT1
Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability
YDR409W 0.21
SIZ1
SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring
YLR307W 0.21
CDA1
Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
YOR231W 0.21
MKK1
Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p
YJR159W 0.21
SOR1
Sorbitol dehydrogenase; expression is induced in the presence of sorbitol
YKL123W 0.21 Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene SSH4
YOR306C 0.21
MCH5
Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport
YMR101C 0.20
SRT1
Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase
YGR226C 0.20 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W
YIL072W 0.20
HOP1
Meiosis-specific DNA binding protein that displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for homologous chromosome synapsis and chiasma formation
YMR306C-A 0.20 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL211C 0.20 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YPL230W 0.20
USV1
Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in protein folding, ATP binding, and cell wall biosynthesis
YIL094C 0.20
LYS12
Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate
YOR113W 0.20
AZF1
Zinc-finger transcription factor, involved in induction of CLN3 transcription in response to glucose; genetic and physical interactions indicate a possible role in mitochondrial transcription or genome maintenance
YDR192C 0.20
NUP42
Subunit of the nuclear pore complex (NPC) that localizes exclusively to the cytoplasmic side; involved in RNA export, most likely at a terminal step; interacts with Gle1p
YKL180W 0.20
RPL17A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Bp and has similarity to E. coli L22 and rat L17 ribosomal proteins; copurifies with the Dam1 complex (aka DASH complex)
YBR124W 0.20 Putative protein of unknown function
YCL066W 0.20
HMLALPHA1
Silenced copy of ALPHA1 at HML, encoding a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression
YBL043W 0.20
ECM13
Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YDL139C 0.20
SCM3
Nonhistone component of centromeric chromatin that binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; contains nuclear export signal (NES); required for G2/M progression and localization of Cse4p
YFR056C 0.19 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YNL171C 0.19 Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YFL020C 0.19
PAU5
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YLR037C 0.19
DAN2
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YBR040W 0.19
FIG1
Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating
YNR062C 0.19 Putative membrane protein of unknown function
YPL027W 0.18
SMA1
Protein of unknown function involved in the assembly of the prospore membrane during sporulation
YFL058W 0.18
THI5
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YKL017C 0.18
HCS1
Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities
YLR111W 0.18 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL036W 0.18
SNX4
Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX domain; forms complexes with Snx41p and with Atg20p
YBL029C-A 0.18 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica
YIL069C 0.18
RPS24B
Protein component of the small (40S) ribosomal subunit; identical to Rps24Ap and has similarity to rat S24 ribosomal protein
YMR118C 0.18 Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene
YDL210W 0.18
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YPR030W 0.18
CSR2
Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate
YBR123C 0.18
TFC1
One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63
YMR295C 0.18 Protein of unknown function that associates with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; YMR295C is not an essential gene
YPR151C 0.18
SUE1
Mitochondrial protein required for degradation of unstable forms of cytochrome c
YKR073C 0.18 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR171W 0.18
HSP42
Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock
YDR389W 0.18
SAC7
GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate
YHR030C 0.18
SLT2
Serine/threonine MAP kinase involved in regulating the maintenance of cell wall integrity and progression through the cell cycle; regulated by the PKC1-mediated signaling pathway
YDL234C 0.17
GYP7
GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking
YOL035C 0.17 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL143C 0.17 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR394W 0.17
RPT3
One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B
YDL037C 0.17
BSC1
Protein of unconfirmed function, similar to cell surface flocculin Muc1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
YDR477W 0.17
SNF1
AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis
YJL188C 0.17
BUD19
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YNR058W 0.17
BIO3
7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis
YLR176C 0.17
RFX1
Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins
YKL190W 0.17
CNB1
Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1
YDR001C 0.17
NTH1
Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p
YER098W 0.16
UBP9
Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions
YAR053W 0.16 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR192C-C 0.16 Putative protein of unknown function; identified by expression profiling and mass spectrometry
YLR108C 0.16 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene
YIL045W 0.16
PIG2
Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase
YDR515W 0.16
SLF1
RNA binding protein that associates with polysomes; proposed to be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts
YIL100W 0.16 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A
YGL156W 0.16
AMS1
Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway
YOL118C 0.16 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YDR193W 0.16 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR090W 0.16 Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR090W is not an essential gene
YAL044C 0.16
GCV3
H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm
YER014C-A 0.16
BUD25
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YBR203W 0.16
COS111
Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPL222C-A 0.16 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching

Network of associatons between targets according to the STRING database.

First level regulatory network of NHP6A

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0090295 nitrogen catabolite repression of transcription(GO:0090295)
0.3 0.9 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
0.2 0.2 GO:0071472 cellular response to salt stress(GO:0071472)
0.2 0.5 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.2 0.5 GO:0009732 detection of chemical stimulus(GO:0009593) detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) detection of stimulus(GO:0051606)
0.2 0.2 GO:0042710 biofilm formation(GO:0042710)
0.2 0.7 GO:0009415 response to water(GO:0009415) cellular response to water stimulus(GO:0071462)
0.2 1.0 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.2 0.5 GO:0006562 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
0.2 0.6 GO:0001323 age-dependent general metabolic decline involved in chronological cell aging(GO:0001323) age-dependent response to oxidative stress involved in chronological cell aging(GO:0001324)
0.1 0.1 GO:0072353 cellular age-dependent response to reactive oxygen species(GO:0072353)
0.1 0.5 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
0.1 0.4 GO:0045895 positive regulation of mating-type specific transcription, DNA-templated(GO:0045895)
0.1 0.4 GO:0030656 regulation of vitamin metabolic process(GO:0030656) positive regulation of vitamin metabolic process(GO:0046136) regulation of thiamine biosynthetic process(GO:0070623) positive regulation of thiamine biosynthetic process(GO:0090180)
0.1 0.3 GO:0043335 protein unfolding(GO:0043335)
0.1 0.4 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.1 0.8 GO:0009102 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.1 0.6 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.1 0.4 GO:0019419 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)(GO:0019379) sulfate reduction(GO:0019419)
0.1 0.5 GO:1903313 positive regulation of mRNA metabolic process(GO:1903313)
0.1 0.5 GO:0009229 thiamine diphosphate biosynthetic process(GO:0009229) thiamine diphosphate metabolic process(GO:0042357)
0.1 0.3 GO:0052547 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
0.1 0.3 GO:0043419 urea catabolic process(GO:0043419)
0.1 0.3 GO:0006883 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.1 0.4 GO:0006546 glycine catabolic process(GO:0006546)
0.1 0.4 GO:0051225 spindle assembly(GO:0051225)
0.1 1.2 GO:0000753 cell morphogenesis involved in conjugation with cellular fusion(GO:0000753)
0.1 0.4 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.1 0.3 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.1 0.2 GO:0006013 mannose metabolic process(GO:0006013)
0.1 0.1 GO:0019627 urea metabolic process(GO:0019627)
0.1 0.4 GO:1901072 aminoglycan catabolic process(GO:0006026) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.1 0.1 GO:0000736 double-strand break repair via single-strand annealing, removal of nonhomologous ends(GO:0000736)
0.1 0.2 GO:0008272 sulfate transport(GO:0008272)
0.1 0.3 GO:0006279 premeiotic DNA replication(GO:0006279)
0.1 0.4 GO:0070941 eisosome assembly(GO:0070941)
0.1 0.2 GO:0045901 positive regulation of translational elongation(GO:0045901)
0.1 0.2 GO:0005993 trehalose catabolic process(GO:0005993)
0.1 0.4 GO:0010388 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.1 0.2 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.1 0.6 GO:0015688 iron chelate transport(GO:0015688)
0.1 0.2 GO:0000092 mitotic anaphase B(GO:0000092)
0.1 0.2 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.1 0.3 GO:0009251 glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.1 0.3 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.1 0.3 GO:0005979 regulation of glycogen biosynthetic process(GO:0005979) regulation of glycogen metabolic process(GO:0070873)
0.1 0.1 GO:0032077 positive regulation of deoxyribonuclease activity(GO:0032077) positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.1 0.4 GO:0009743 response to carbohydrate(GO:0009743)
0.1 0.7 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 0.2 GO:0070054 mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response(GO:0030969) IRE1-mediated unfolded protein response(GO:0036498) mRNA splicing, via endonucleolytic cleavage and ligation(GO:0070054)
0.1 0.3 GO:0045597 positive regulation of cell fate commitment(GO:0010455) positive regulation of mating type switching(GO:0031496) positive regulation of cell differentiation(GO:0045597)
0.1 0.2 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037) actin filament reorganization(GO:0090527)
0.1 0.3 GO:0031507 heterochromatin assembly(GO:0031507)
0.1 0.1 GO:0032075 positive regulation of nuclease activity(GO:0032075)
0.1 0.2 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.0 0.5 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.1 GO:1901800 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800) positive regulation of proteolysis involved in cellular protein catabolic process(GO:1903052) positive regulation of cellular protein catabolic process(GO:1903364)
0.0 0.1 GO:0061395 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061395) cellular response to arsenic-containing substance(GO:0071243)
0.0 0.1 GO:0035950 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
0.0 0.1 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.5 GO:0006772 thiamine metabolic process(GO:0006772)
0.0 0.1 GO:0018105 peptidyl-serine phosphorylation(GO:0018105) peptidyl-serine modification(GO:0018209)
0.0 0.4 GO:0007129 synapsis(GO:0007129)
0.0 0.0 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.3 GO:0001041 transcription from RNA polymerase III type 2 promoter(GO:0001009) transcription from a RNA polymerase III hybrid type promoter(GO:0001041)
0.0 0.2 GO:0045033 peroxisome inheritance(GO:0045033)
0.0 0.2 GO:0055075 cellular potassium ion homeostasis(GO:0030007) potassium ion homeostasis(GO:0055075)
0.0 0.3 GO:0051346 negative regulation of hydrolase activity(GO:0051346)
0.0 0.1 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571) mitotic G1/S transition checkpoint(GO:0044819)
0.0 0.1 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.0 0.1 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.0 0.5 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.0 0.2 GO:0042173 regulation of sporulation resulting in formation of a cellular spore(GO:0042173)
0.0 0.1 GO:0015847 putrescine transport(GO:0015847)
0.0 0.1 GO:0072361 regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361) regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072363)
0.0 0.2 GO:0007234 osmosensory signaling via phosphorelay pathway(GO:0007234)
0.0 0.2 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
0.0 0.4 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.0 0.1 GO:0030491 heteroduplex formation(GO:0030491)
0.0 0.1 GO:0006827 high-affinity iron ion transmembrane transport(GO:0006827)
0.0 0.2 GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000461)
0.0 0.1 GO:0043388 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
0.0 0.1 GO:0031114 negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
0.0 0.3 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 0.2 GO:0000730 meiotic DNA recombinase assembly(GO:0000707) DNA recombinase assembly(GO:0000730)
0.0 0.2 GO:0030261 chromosome condensation(GO:0030261)
0.0 0.1 GO:0015976 carbon utilization(GO:0015976)
0.0 0.1 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.0 0.1 GO:0019626 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
0.0 0.1 GO:0006577 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
0.0 0.3 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.0 0.1 GO:0015883 FAD transport(GO:0015883)
0.0 0.1 GO:0090399 replicative senescence(GO:0090399)
0.0 0.1 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.0 0.1 GO:0006527 arginine catabolic process(GO:0006527)
0.0 0.0 GO:1904667 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.0 0.1 GO:1901654 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898) response to ketone(GO:1901654)
0.0 0.1 GO:1900544 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.0 0.4 GO:0030242 pexophagy(GO:0030242)
0.0 0.2 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.0 0.3 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.1 GO:0015740 C4-dicarboxylate transport(GO:0015740)
0.0 0.6 GO:0006378 mRNA polyadenylation(GO:0006378)
0.0 0.1 GO:0006037 cell wall chitin metabolic process(GO:0006037)
0.0 0.1 GO:0032443 regulation of steroid metabolic process(GO:0019218) regulation of ergosterol biosynthetic process(GO:0032443) regulation of steroid biosynthetic process(GO:0050810)
0.0 0.3 GO:0031578 mitotic spindle orientation checkpoint(GO:0031578)
0.0 0.4 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0 0.1 GO:0061392 regulation of transcription from RNA polymerase II promoter in response to osmotic stress(GO:0061392)
0.0 0.0 GO:0061013 regulation of mRNA catabolic process(GO:0061013)
0.0 0.1 GO:0070933 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0 0.1 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0 0.2 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 0.1 GO:0007534 gene conversion at mating-type locus(GO:0007534)
0.0 0.1 GO:0000042 protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.0 0.9 GO:0051304 chromosome separation(GO:0051304)
0.0 0.1 GO:0034198 cellular response to amino acid starvation(GO:0034198)
0.0 0.1 GO:0048313 Golgi inheritance(GO:0048313)
0.0 0.0 GO:0071050 snoRNA polyadenylation(GO:0071050)
0.0 0.1 GO:0000729 meiotic DNA double-strand break processing(GO:0000706) DNA double-strand break processing(GO:0000729)
0.0 0.2 GO:2000144 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 0.5 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.0 GO:1902222 L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.0 0.1 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.0 GO:0044783 G1 DNA damage checkpoint(GO:0044783)
0.0 0.7 GO:0040020 regulation of meiotic nuclear division(GO:0040020)
0.0 0.2 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.2 GO:0044091 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.0 0.2 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.0 0.0 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.0 0.1 GO:1900436 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
0.0 0.1 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 0.3 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.1 GO:0019932 second-messenger-mediated signaling(GO:0019932)
0.0 0.0 GO:0033262 regulation of nuclear cell cycle DNA replication(GO:0033262)
0.0 0.0 GO:0000279 mitotic M phase(GO:0000087) M phase(GO:0000279)
0.0 0.2 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.0 0.1 GO:0051046 regulation of exocytosis(GO:0017157) regulation of secretion(GO:0051046) regulation of secretion by cell(GO:1903530)
0.0 0.2 GO:0051180 vitamin transport(GO:0051180)
0.0 0.1 GO:0000078 obsolete cytokinesis after mitosis checkpoint(GO:0000078) positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.0 0.1 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.0 0.0 GO:0043937 regulation of sporulation(GO:0043937)
0.0 0.7 GO:0070590 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
0.0 0.1 GO:0032231 regulation of actin filament bundle assembly(GO:0032231) positive regulation of actin filament bundle assembly(GO:0032233)
0.0 0.1 GO:0046688 response to copper ion(GO:0046688)
0.0 0.3 GO:0030474 spindle pole body duplication(GO:0030474)
0.0 0.0 GO:0043270 positive regulation of ion transport(GO:0043270)
0.0 0.1 GO:0051231 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231)
0.0 0.1 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.0 0.0 GO:0071361 positive regulation of transcription from RNA polymerase II promoter in response to ethanol(GO:0061410) cellular response to ethanol(GO:0071361) cellular response to alcohol(GO:0097306)
0.0 0.1 GO:0000710 meiotic mismatch repair(GO:0000710)
0.0 0.1 GO:0097053 L-kynurenine metabolic process(GO:0097052) L-kynurenine catabolic process(GO:0097053)
0.0 0.1 GO:0016233 telomere capping(GO:0016233)
0.0 0.1 GO:0035392 maintenance of chromatin silencing(GO:0006344) maintenance of chromatin silencing at telomere(GO:0035392)
0.0 0.2 GO:0007121 bipolar cellular bud site selection(GO:0007121)
0.0 0.1 GO:0015809 arginine transport(GO:0015809)
0.0 0.0 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0 0.0 GO:2000284 positive regulation of cellular amino acid metabolic process(GO:0045764) positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.0 0.1 GO:0015758 glucose transport(GO:0015758)
0.0 0.0 GO:0001315 age-dependent response to reactive oxygen species(GO:0001315)
0.0 0.1 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.0 GO:1900062 regulation of cell aging(GO:0090342) regulation of replicative cell aging(GO:1900062)
0.0 0.1 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.7 GO:0018393 internal protein amino acid acetylation(GO:0006475) histone acetylation(GO:0016573) internal peptidyl-lysine acetylation(GO:0018393) peptidyl-lysine acetylation(GO:0018394)
0.0 0.1 GO:1903726 negative regulation of phospholipid biosynthetic process(GO:0071072) negative regulation of phospholipid metabolic process(GO:1903726)
0.0 0.0 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900) tetrahydrofolylpolyglutamate biosynthetic process(GO:0046901)
0.0 0.1 GO:0009410 response to xenobiotic stimulus(GO:0009410)
0.0 0.2 GO:0006284 base-excision repair(GO:0006284)
0.0 0.1 GO:0043200 response to amino acid(GO:0043200)
0.0 0.1 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.1 GO:0055070 cellular copper ion homeostasis(GO:0006878) copper ion homeostasis(GO:0055070)
0.0 0.0 GO:0046185 aldehyde catabolic process(GO:0046185)
0.0 0.0 GO:0000957 mitochondrial RNA catabolic process(GO:0000957)
0.0 0.3 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.1 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.0 0.1 GO:0009371 positive regulation of transcription from RNA polymerase II promoter by pheromones(GO:0007329) positive regulation of transcription by pheromones(GO:0009371)
0.0 0.0 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.0 0.0 GO:0016077 snRNA catabolic process(GO:0016076) snoRNA catabolic process(GO:0016077) nuclear polyadenylation-dependent snoRNA catabolic process(GO:0071036) nuclear polyadenylation-dependent snRNA catabolic process(GO:0071037)
0.0 0.0 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.0 0.2 GO:0007118 budding cell apical bud growth(GO:0007118)
0.0 0.1 GO:0032147 activation of protein kinase activity(GO:0032147)
0.0 0.0 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.0 0.1 GO:0043954 cellular component maintenance(GO:0043954)
0.0 0.2 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.2 GO:0042026 protein refolding(GO:0042026)
0.0 0.0 GO:0097271 protein localization to bud neck(GO:0097271)
0.0 0.1 GO:0048478 replication fork protection(GO:0048478) negative regulation of DNA-dependent DNA replication(GO:2000104)
0.0 0.1 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.0 0.0 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.0 0.1 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 0.0 GO:0031335 regulation of sulfur amino acid metabolic process(GO:0031335)
0.0 0.1 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.1 GO:0000743 nuclear migration involved in conjugation with cellular fusion(GO:0000743)
0.0 0.1 GO:0015908 fatty acid transport(GO:0015908)
0.0 0.1 GO:0000084 mitotic S phase(GO:0000084) S phase(GO:0051320)
0.0 0.3 GO:0009272 fungal-type cell wall biogenesis(GO:0009272)
0.0 0.1 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.2 GO:0045991 carbon catabolite activation of transcription(GO:0045991)
0.0 0.1 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.0 0.1 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.0 0.0 GO:0009847 spore germination(GO:0009847)
0.0 0.0 GO:0034310 ethanol catabolic process(GO:0006068) primary alcohol catabolic process(GO:0034310)
0.0 0.1 GO:0043486 histone exchange(GO:0043486)
0.0 0.0 GO:0000272 polysaccharide catabolic process(GO:0000272)
0.0 0.3 GO:0006887 exocytosis(GO:0006887)
0.0 0.0 GO:0015691 cadmium ion transport(GO:0015691)
0.0 0.1 GO:1905037 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.0 0.1 GO:0006808 regulation of nitrogen utilization(GO:0006808)
0.0 0.2 GO:0006301 postreplication repair(GO:0006301)
0.0 0.0 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 0.2 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 0.4 GO:0005960 glycine cleavage complex(GO:0005960)
0.1 0.3 GO:0034990 mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990)
0.1 0.7 GO:0005619 ascospore wall(GO:0005619)
0.1 0.3 GO:0001400 mating projection base(GO:0001400)
0.1 0.4 GO:0008180 COP9 signalosome(GO:0008180)
0.1 0.5 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.1 0.4 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.1 0.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 0.3 GO:0033100 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.1 0.5 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 0.3 GO:0005871 kinesin complex(GO:0005871)
0.1 0.4 GO:0034657 GID complex(GO:0034657)
0.1 0.2 GO:0097042 extrinsic component of fungal-type vacuolar membrane(GO:0097042)
0.1 0.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.1 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.2 GO:0072379 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.0 0.4 GO:0000795 synaptonemal complex(GO:0000795)
0.0 0.2 GO:0005823 central plaque of spindle pole body(GO:0005823)
0.0 0.1 GO:0034099 luminal surveillance complex(GO:0034099)
0.0 0.3 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.1 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.0 0.1 GO:0008278 nuclear cohesin complex(GO:0000798) cohesin complex(GO:0008278)
0.0 0.1 GO:0031518 CBF3 complex(GO:0031518)
0.0 0.1 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.2 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.5 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.4 GO:0005940 septin ring(GO:0005940)
0.0 0.2 GO:0000796 condensin complex(GO:0000796) nuclear condensin complex(GO:0000799)
0.0 0.1 GO:0033263 CORVET complex(GO:0033263)
0.0 0.6 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.0 0.2 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.1 GO:0032156 septin cytoskeleton(GO:0032156)
0.0 0.2 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.4 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.0 0.2 GO:0030897 HOPS complex(GO:0030897)
0.0 0.1 GO:0031262 Ndc80 complex(GO:0031262)
0.0 0.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.1 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.0 0.1 GO:0005880 nuclear microtubule(GO:0005880)
0.0 0.2 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.0 0.3 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.1 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.0 0.1 GO:0033597 mitotic checkpoint complex(GO:0033597)
0.0 0.1 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.0 0.4 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.0 0.1 GO:0032126 eisosome(GO:0032126)
0.0 0.1 GO:0005771 multivesicular body(GO:0005771)
0.0 0.4 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.0 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)
0.0 0.0 GO:0045240 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.1 GO:0051286 cell tip(GO:0051286)
0.0 0.5 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.1 GO:0031417 NatC complex(GO:0031417)
0.0 0.2 GO:0090544 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.0 0.1 GO:0032221 Rpd3S complex(GO:0032221)
0.0 0.2 GO:0016586 RSC complex(GO:0016586)
0.0 0.1 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.1 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.0 GO:0032389 MutLalpha complex(GO:0032389)
0.0 0.4 GO:0005628 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.0 0.1 GO:0000446 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) nucleoplasmic THO complex(GO:0000446)
0.0 0.2 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.0 0.0 GO:0070211 Snt2C complex(GO:0070211)
0.0 0.0 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.0 GO:0000974 Prp19 complex(GO:0000974)
0.0 0.1 GO:0000133 polarisome(GO:0000133)
0.0 0.1 GO:0000782 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0 0.1 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.1 GO:1903293 protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0 0.8 GO:0000922 spindle pole(GO:0000922)
0.0 0.1 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.0 GO:0035649 Nrd1 complex(GO:0035649)
0.0 0.1 GO:0032806 carboxy-terminal domain protein kinase complex(GO:0032806)
0.0 0.3 GO:0071004 U2-type prespliceosome(GO:0071004) prespliceosome(GO:0071010)
0.0 0.0 GO:0070274 RES complex(GO:0070274)
0.0 0.2 GO:0070847 core mediator complex(GO:0070847)
0.0 0.0 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.0 GO:0044697 HICS complex(GO:0044697)
0.0 0.0 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.0 0.0 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0000772 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.2 0.7 GO:0015603 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.2 0.7 GO:0005537 mannose binding(GO:0005537)
0.2 0.5 GO:0005536 glucose binding(GO:0005536)
0.2 0.6 GO:0000156 phosphorelay response regulator activity(GO:0000156)
0.1 0.5 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
0.1 0.5 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.1 0.4 GO:0008972 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.1 0.3 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.1 0.3 GO:0030414 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
0.1 0.4 GO:0016642 glycine dehydrogenase (decarboxylating) activity(GO:0004375) oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor(GO:0016642)
0.1 0.4 GO:0004338 glucan exo-1,3-beta-glucosidase activity(GO:0004338)
0.1 0.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 0.3 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 0.5 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 0.4 GO:0016783 sulfurtransferase activity(GO:0016783)
0.1 0.5 GO:0005354 galactose transmembrane transporter activity(GO:0005354)
0.1 0.9 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 0.2 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.1 0.2 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
0.1 0.2 GO:0004555 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.1 0.2 GO:0032183 SUMO binding(GO:0032183)
0.1 0.2 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.1 0.3 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.1 0.3 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 0.1 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.1 0.1 GO:0008157 protein phosphatase 1 binding(GO:0008157) phosphatase binding(GO:0019902) protein phosphatase binding(GO:0019903)
0.1 0.2 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.1 0.4 GO:0031072 heat shock protein binding(GO:0031072)
0.1 0.3 GO:0019789 SUMO transferase activity(GO:0019789)
0.1 0.5 GO:0004497 monooxygenase activity(GO:0004497)
0.0 0.1 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.0 0.1 GO:0016882 cyclo-ligase activity(GO:0016882)
0.0 0.1 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.0 0.1 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0 0.3 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 0.2 GO:0043139 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 0.2 GO:0004559 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.0 2.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.6 GO:0005057 receptor signaling protein activity(GO:0005057)
0.0 0.2 GO:0019212 protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
0.0 0.3 GO:0001008 RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003) transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting(GO:0001004) transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIB recruiting(GO:0001005) transcription factor activity, RNA polymerase III type 2 promoter sequence-specific binding, TFIIIB recruiting(GO:0001008) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034)
0.0 0.1 GO:0005034 osmosensor activity(GO:0005034)
0.0 0.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.3 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.2 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.2 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.4 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.1 GO:0004771 sterol esterase activity(GO:0004771)
0.0 0.1 GO:0048256 5'-flap endonuclease activity(GO:0017108) flap endonuclease activity(GO:0048256)
0.0 0.7 GO:0019783 ubiquitin-like protein-specific protease activity(GO:0019783)
0.0 0.1 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
0.0 0.4 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0 0.3 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.3 GO:0031386 protein tag(GO:0031386)
0.0 0.2 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 0.6 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.6 GO:0019213 deacetylase activity(GO:0019213)
0.0 0.1 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.0 0.1 GO:0042802 identical protein binding(GO:0042802)
0.0 0.1 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
0.0 0.1 GO:0055103 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.1 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 0.4 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.0 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.0 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.6 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.1 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0 0.1 GO:0001091 RNA polymerase II basal transcription factor binding(GO:0001091)
0.0 0.0 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139)
0.0 0.1 GO:0042736 NAD+ kinase activity(GO:0003951) NADH kinase activity(GO:0042736)
0.0 0.1 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.2 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 0.4 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 0.1 GO:0016208 AMP binding(GO:0016208)
0.0 2.1 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 0.8 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.0 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.3 GO:0015293 symporter activity(GO:0015293)
0.0 0.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.1 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.0 0.1 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.2 GO:0000149 SNARE binding(GO:0000149)
0.0 0.3 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.1 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 0.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.1 GO:0032947 protein complex scaffold(GO:0032947)
0.0 0.1 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.0 0.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.3 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.1 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.1 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.2 GO:0015079 potassium ion transmembrane transporter activity(GO:0015079)
0.0 0.2 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.0 0.1 GO:0019237 centromeric DNA binding(GO:0019237)
0.0 0.1 GO:0017022 myosin binding(GO:0017022)
0.0 0.4 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.0 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0 0.3 GO:0019208 phosphatase regulator activity(GO:0019208)
0.0 0.0 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.0 0.0 GO:0004326 tetrahydrofolylpolyglutamate synthase activity(GO:0004326)
0.0 0.1 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.1 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.0 0.0 GO:0072341 modified amino acid binding(GO:0072341)
0.0 0.9 GO:0000988 transcription factor activity, protein binding(GO:0000988)
0.0 0.1 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.4 GO:0004402 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.0 1.1 GO:0005543 phospholipid binding(GO:0005543)
0.0 0.1 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.0 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.2 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.8 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 0.1 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.0 0.3 GO:0042393 histone binding(GO:0042393)
0.0 0.1 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.1 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.0 0.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.0 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0 0.1 GO:0008198 ferrous iron binding(GO:0008198)
0.0 0.0 GO:0004602 glutathione peroxidase activity(GO:0004602) phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.0 0.0 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.0 GO:0015385 sodium:proton antiporter activity(GO:0015385)
0.0 0.1 GO:0045182 translation regulator activity(GO:0045182)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 PID ERBB4 PATHWAY ErbB4 signaling events
0.1 0.3 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 0.4 PID E2F PATHWAY E2F transcription factor network
0.0 0.1 PID FOXO PATHWAY FoxO family signaling
0.0 0.2 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.1 PID ATR PATHWAY ATR signaling pathway
0.0 0.1 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.2 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.0 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 0.4 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 0.4 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 0.2 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 0.3 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 0.2 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.1 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.1 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.1 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.1 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.0 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.1 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA