Results for NHP10
Z-value: 1.61
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Transcription factors associated with NHP10
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
NHP10
|
S000002160 | Protein related to mammalian high mobility group proteins |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YGR067C Show fit | 20.01 |
Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p |
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| YJL045W Show fit | 13.89 |
Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner |
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| YML042W Show fit | 13.45 |
Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes |
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| YIL057C Show fit | 12.24 |
Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose |
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| YPL054W Show fit | 11.95 |
Zinc-finger protein of unknown function |
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| YDR277C Show fit | 11.18 |
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation |
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| YLR312C Show fit | 10.80 |
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity |
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| YCR007C Show fit | 10.65 |
Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene |
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| YOR100C Show fit | 10.49 |
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation |
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| YDL210W Show fit | 10.18 |
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane |
Network of associatons between targets according to the STRING database.
First level regulatory network of NHP10
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 32.2 | GO:0009060 | aerobic respiration(GO:0009060) |
| 2.7 | 27.2 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 0.9 | 26.1 | GO:0006094 | gluconeogenesis(GO:0006094) |
| 6.2 | 18.5 | GO:0006577 | amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437) |
| 1.9 | 15.5 | GO:0015758 | glucose transport(GO:0015758) |
| 0.9 | 15.3 | GO:0005978 | glycogen biosynthetic process(GO:0005978) |
| 3.0 | 14.8 | GO:0006121 | mitochondrial electron transport, succinate to ubiquinone(GO:0006121) |
| 4.8 | 14.3 | GO:0015755 | fructose transport(GO:0015755) |
| 1.4 | 12.2 | GO:0046487 | glyoxylate metabolic process(GO:0046487) |
| 1.3 | 11.3 | GO:0070086 | ubiquitin-dependent endocytosis(GO:0070086) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 56.3 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 39.3 | GO:0005739 | mitochondrion(GO:0005739) |
| 1.5 | 32.5 | GO:0070469 | respiratory chain(GO:0070469) |
| 3.0 | 14.8 | GO:0045283 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
| 0.3 | 11.6 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 10.5 | GO:0098852 | fungal-type vacuole membrane(GO:0000329) lytic vacuole membrane(GO:0098852) |
| 0.3 | 9.7 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 2.3 | 9.1 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.5 | 8.2 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 0.5 | 8.2 | GO:0031307 | intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.2 | 18.5 | GO:0004092 | carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406) |
| 3.0 | 14.8 | GO:0008177 | succinate dehydrogenase (ubiquinone) activity(GO:0008177) |
| 0.8 | 13.0 | GO:0046906 | heme binding(GO:0020037) tetrapyrrole binding(GO:0046906) |
| 0.6 | 11.4 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 1.4 | 11.3 | GO:0016681 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.8 | 10.9 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389) |
| 0.6 | 10.4 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.4 | 10.4 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
| 0.9 | 10.3 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 3.4 | 10.2 | GO:0015489 | putrescine transmembrane transporter activity(GO:0015489) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 69.4 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 3.0 | 8.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 1.1 | 3.4 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.3 | 2.4 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.4 | 1.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.4 | 1.1 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.3 | 1.0 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 0.7 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.2 | 0.6 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 0.3 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 63.8 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 1.8 | 16.6 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 2.7 | 8.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 1.4 | 4.2 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.3 | 0.9 | REACTOME PI3K EVENTS IN ERBB2 SIGNALING | Genes involved in PI3K events in ERBB2 signaling |
| 0.2 | 0.7 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.2 | 0.7 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 0.2 | REACTOME HEMOSTASIS | Genes involved in Hemostasis |
| 0.1 | 0.1 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 0.0 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |