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Results for NHP10

Z-value: 1.61

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Transcription factors associated with NHP10

Gene Symbol Gene ID Gene Info
NHP10
S000002160 Protein related to mammalian high mobility group proteins

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NHP10YDL002C-0.349.4e-02Click!

Activity profile of NHP10 motif

Sorted Z-values of NHP10 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YGR067C 20.01 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YJL045W 13.89 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YML042W 13.45
CAT2
Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
YIL057C 12.24 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YPL054W 11.95
LEE1
Zinc-finger protein of unknown function
YDR277C 11.18
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YLR312C 10.80
QNQ1
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YCR007C 10.65 Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YOR100C 10.49
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YDL210W 10.18
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YLR327C 10.18
TMA10
Protein of unknown function that associates with ribosomes
YPR036W-A 9.68 Protein of unknown function; transcription is regulated by Pdr1p
YKR097W 9.39
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YKL109W 9.11
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YPR030W 9.06
CSR2
Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate
YFR053C 9.03
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YOR343C 8.76 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YMR175W 8.64
SIP18
Protein of unknown function whose expression is induced by osmotic stress
YDL204W 8.25
RTN2
Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily
YJR048W 8.23
CYC1
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YEL039C 8.06
CYC7
Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YDR343C 7.89
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YER084W 7.56 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR206W 7.35 Putative protein of unknown function; YMR206W is not an essential gene
YLR346C 7.10 Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene
YJR115W 6.91 Putative protein of unknown function
YOR120W 6.86
GCY1
Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family
YNL305C 6.73 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL305C is not an essential gene
YGR243W 6.71
FMP43
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR406W 6.69
PDR15
Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
YFL052W 6.58 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YKL148C 6.42
SDH1
Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YEL011W 6.28
GLC3
Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YOL051W 6.16
GAL11
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors
YIL125W 6.07
KGD1
Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA
YML089C 6.04 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YAL039C 6.02
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YBL064C 5.95
PRX1
Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress; phosphorylated
YDR178W 5.79
SDH4
Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YEL012W 5.74
UBC8
Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
YOL081W 5.74
IRA2
GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin
YJR095W 5.70
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YKL163W 5.68
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YMR081C 5.65
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YMR280C 5.65
CAT8
Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements
YKL026C 5.56
GPX1
Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YGR032W 5.50
GSC2
Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
YKL093W 5.40
MBR1
Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants
YLR174W 5.33
IDP2
Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
YBR117C 5.28
TKL2
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YDL194W 5.24
SNF3
Plasma membrane glucose sensor that regulates glucose transport; has 12 predicted transmembrane segments; long cytoplasmic C-terminal tail is required for low glucose induction of hexose transporter genes HXT2 and HXT4
YDL085W 5.24
NDE2
Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
YCR021C 5.22
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YAR035W 5.10
YAT1
Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
YPL089C 5.03
RLM1
MADS-box transcription factor, component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p
YGL192W 5.03
IME4
Probable mRNA N6-adenosine methyltransferase that is required for IME1 transcript accumulation and for sporulation; expression is induced in starved MATa/MAT alpha diploid cells
YPR184W 5.01
GDB1
Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria
YGL191W 4.94
COX13
Subunit VIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP
YGL193C 4.93 Haploid-specific gene repressed by a1-alpha2, turned off in sir3 null strains, absence enhances the sensitivity of rad52-327 cells to campothecin almost 100-fold
YMR306C-A 4.90 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR015C 4.78 Putative protein of unknown function
YIL162W 4.77
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YDR216W 4.76
ADR1
Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
YLR334C 4.70 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here
YNL117W 4.67
MLS1
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YGL062W 4.66
PYC1
Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis
YBL015W 4.52
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YBR230C 4.51
OM14
Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron
YBR051W 4.33 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase
YPR007C 4.22
REC8
Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p
YBR050C 4.11
REG2
Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
YFR029W 4.07
PTR3
Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
YDR298C 3.98
ATP5
Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
YGR144W 3.93
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YOR348C 3.88
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YOR371C 3.88
GPB1
Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb2p
YDR119W-A 3.87 Putative protein of unknown function
YDR342C 3.79
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YKL217W 3.70
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YLR356W 3.68 Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YGR023W 3.67
MTL1
Protein with both structural and functional similarity to Mid2p, which is a plasma membrane sensor required for cell integrity signaling during pheromone-induced morphogenesis; suppresses rgd1 null mutations
YML090W 3.66 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YDR231C 3.63
COX20
Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
YIL055C 3.61 Putative protein of unknown function
YIL024C 3.59 Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p
YIL122W 3.59
POG1
Putative transcriptional activator that promotes recovery from pheromone induced arrest; inhibits both alpha-factor induced G1 arrest and repression of CLN1 and CLN2 via SCB/MCB promoter elements; potential Cdc28p substrate; SBF regulated
YGR022C 3.57 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
YMR311C 3.56
GLC8
Regulatory subunit of protein phosphatase 1 (Glc7p), involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2
YPL240C 3.53
HSP82
Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
YJL103C 3.49
GSM1
Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis
YDR262W 3.46 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment
YDL130W-A 3.42
STF1
Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein
YMR174C 3.41
PAI3
Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact
YPL088W 3.40 Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
YEL060C 3.39
PRB1
Vacuolar proteinase B (yscB), a serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation
YDL182W 3.38
LYS20
Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys21p
YOR383C 3.38
FIT3
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YPL024W 3.38
RMI1
Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YDR096W 3.33
GIS1
JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1
YGR183C 3.31
QCR9
Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
YPR005C 3.31
HAL1
Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p
YDR092W 3.30
UBC13
Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus
YPR191W 3.29
QCR2
Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme
YHR139C 3.28
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YPL229W 3.26 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL229W is not an essential gene
YPR026W 3.24
ATH1
Acid trehalase required for utilization of extracellular trehalose
YLR377C 3.23
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YLR304C 3.22
ACO1
Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy
YIL155C 3.19
GUT2
Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner
YPL201C 3.17
YIG1
Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol
YBR021W 3.16
FUR4
Uracil permease, localized to the plasma membrane; expression is tightly regulated by uracil levels and environmental cues
YNL125C 3.09
ESBP6
Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
YKL044W 3.08 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YML120C 3.06
NDI1
NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID
YNL274C 3.04
GOR1
Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPL026C 3.01
SKS1
Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YER067C-A 2.99 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
YGR258C 2.95
RAD2
Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
YGL146C 2.95 Putative protein of unknown function, contains two putative transmembrane spans, shows no significant homology to any other known protein sequence, YGL146C is not an essential gene
YPL156C 2.92
PRM4
Pheromone-regulated protein, predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift
YLR055C 2.90
SPT8
Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
YDR259C 2.84
YAP6
Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance
YEL049W 2.84
PAU2
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YER098W 2.83
UBP9
Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions
YML091C 2.82
RPM2
Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
YGR043C 2.82
NQM1
Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity
YNL074C 2.79
MLF3
Serine-rich protein of unknown function; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
YHR096C 2.78
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YOL055C 2.77
THI20
Multifunctional protein with both hydroxymethylpyrimidine kinase and thiaminase activities; involved in thiamine biosynthesis and also in thiamine degradation; member of a gene family with THI21 and THI22; functionally redundant with Thi21p
YKL085W 2.75
MDH1
Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated
YJL161W 2.73
FMP33
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR399C 2.73
BDF1
Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p
YMR040W 2.73
YET2
Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
YDR269C 2.66 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL146W 2.65
AVT3
Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YKL147C 2.65 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3
YER033C 2.64
ZRG8
Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency
YNR002C 2.60
ATO2
Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p
YOR328W 2.59
PDR10
ATP-binding cassette (ABC) transporter, multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p
YKL141W 2.59
SDH3
Cytochrome b subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YJR150C 2.57
DAN1
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YPR006C 2.56
ICL2
2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol
YMR103C 2.54 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR270W 2.53
CCC2
Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases
YAL020C 2.51
ATS1
Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle
YJL133C-A 2.51 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNL055C 2.48
POR1
Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated
YDR232W 2.47
HEM1
5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
YAR053W 2.47 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YER185W 2.45
PUG1
Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions
YPL189C-A 2.41
COA2
Putative cytochrome oxidase assembly factor; identified by homology to Ashbya gossypii; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity
YGL117W 2.40 Putative protein of unknown function
YJR138W 2.39
IML1
Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane
YOR139C 2.38 Hypothetical protein
YJR151C 2.38
DAN4
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YPR023C 2.38
EAF3
Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition
YFR033C 2.37
QCR6
Subunit 6 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1
YJR078W 2.34
BNA2
Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p
YBR297W 2.33
MAL33
MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C
YAL019W-A 2.32 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YFL024C 2.32
EPL1
Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb
YJL102W 2.32
MEF2
Mitochondrial elongation factor involved in translational elongation
YMR170C 2.29
ALD2
Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p
YJL100W 2.26
LSB6
Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
YLR152C 2.26 Putative protein of unknown function; YLR152C is not an essential gene
YNR034W 2.24
SOL1
Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol2p, Sol3p, and Sol4p
YML081C-A 2.24
ATP18
Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms
YMR272C 2.22
SCS7
Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth
YGL194C 2.19
HOS2
Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity
YDR528W 2.19
HLR1
Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A
YJL152W 2.18 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL018C 2.18 Putative protein of unknown function
YMR213W 2.18
CEF1
Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
YGL236C 2.15
MTO1
Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants
YNL283C 2.15
WSC2
Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response
YOR140W 2.15
SFL1
Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p
YMR017W 2.15
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YDL079C 2.15
MRK1
Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation
YKL043W 2.15
PHD1
Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate
YHR021W-A 2.14
ECM12
Non-essential protein of unknown function
YMR291W 2.12 Putative kinase of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR291W is not an essential gene
YKL031W 2.12 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YDL138W 2.07
RGT2
Plasma membrane glucose receptor, highly similar to Snf3p; both Rgt2p and Snf3p serve as transmembrane glucose sensors generating an intracellular signal that induces expression of glucose transporter (HXT) genes
YBR230W-A 2.05 Putative protein of unknown function
YHR126C 2.04 Putative protein of unknown function; transcription dependent upon Azf1p
YCR010C 2.04
ADY2
Acetate transporter required for normal sporulation; phosphorylated in mitochondria
YFR016C 2.04 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene
YLR438W 2.02
CAR2
L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive
YOL052C-A 2.01
DDR2
Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses
YKL133C 2.00 Putative protein of unknown function
YDL183C 1.99 Putative protein of unknown function; YDL183C is not an essential gene
YHR052W-A 1.99 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CUP1-1
YNL242W 1.98
ATG2
Peripheral membrane protein required for vesicle formation during autophagy, pexophagy, and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the pre-autophagosomal structure and mitochondria
YMR107W 1.96
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YNR073C 1.95 Putative mannitol dehydrogenase
YOR244W 1.95
ESA1
Histone acetyltransferase catalytic subunit of the native multisubunit complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail; required for cell cycle progression
YER142C 1.94
MAG1
3-methyl-adenine DNA glycosylase involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired
YER158C 1.94 Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p
YDR275W 1.93
BSC2
Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
YHL024W 1.91
RIM4
Putative RNA-binding protein required for the expression of early and middle sporulation genes

Network of associatons between targets according to the STRING database.

First level regulatory network of NHP10

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.2 18.5 GO:0006577 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
4.8 14.3 GO:0015755 fructose transport(GO:0015755)
3.0 14.8 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
2.9 8.6 GO:0032780 negative regulation of ATPase activity(GO:0032780)
2.9 5.7 GO:0045980 negative regulation of nucleotide metabolic process(GO:0045980)
2.7 27.2 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
2.3 6.9 GO:0042843 D-xylose catabolic process(GO:0042843)
2.1 8.5 GO:0006848 pyruvate transport(GO:0006848)
2.1 6.2 GO:0017003 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
1.9 15.5 GO:0015758 glucose transport(GO:0015758)
1.9 7.7 GO:0015847 putrescine transport(GO:0015847)
1.9 5.7 GO:0015740 C4-dicarboxylate transport(GO:0015740)
1.9 5.7 GO:0061413 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
1.9 5.6 GO:0034310 ethanol catabolic process(GO:0006068) primary alcohol catabolic process(GO:0034310)
1.7 6.6 GO:0071462 response to water(GO:0009415) cellular response to water stimulus(GO:0071462)
1.5 6.1 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
1.5 7.6 GO:0043954 cellular component maintenance(GO:0043954)
1.4 5.5 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
1.4 12.2 GO:0046487 glyoxylate metabolic process(GO:0046487)
1.3 6.4 GO:0005980 glycogen catabolic process(GO:0005980)
1.3 6.4 GO:0006083 acetate metabolic process(GO:0006083)
1.3 11.3 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
1.3 3.8 GO:0052547 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
1.2 3.5 GO:0032874 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
1.2 4.7 GO:0015804 neutral amino acid transport(GO:0015804)
1.1 3.3 GO:0006108 malate metabolic process(GO:0006108)
1.1 3.3 GO:0010994 free ubiquitin chain polymerization(GO:0010994)
1.1 3.2 GO:0005993 trehalose catabolic process(GO:0005993)
1.0 4.1 GO:0043388 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
1.0 3.1 GO:0043068 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
1.0 4.1 GO:0043200 response to amino acid(GO:0043200)
1.0 2.9 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
1.0 1.9 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.9 3.8 GO:0070988 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.9 26.1 GO:0006094 gluconeogenesis(GO:0006094)
0.9 15.3 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.9 4.3 GO:0019563 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.9 2.6 GO:0019626 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
0.8 4.2 GO:0001678 cellular glucose homeostasis(GO:0001678) carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255) carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.8 4.1 GO:0034627 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.8 9.8 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.8 3.2 GO:0015855 pyrimidine nucleobase transport(GO:0015855)
0.8 3.1 GO:0006527 arginine catabolic process(GO:0006527)
0.8 1.5 GO:0006824 cobalt ion transport(GO:0006824)
0.7 1.5 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.7 4.3 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.7 5.8 GO:0015891 siderophore transport(GO:0015891)
0.7 1.4 GO:0008216 spermidine metabolic process(GO:0008216)
0.7 0.7 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.7 3.5 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.7 32.2 GO:0009060 aerobic respiration(GO:0009060)
0.7 2.7 GO:0031507 heterochromatin assembly(GO:0031507)
0.7 5.4 GO:0005987 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.7 8.0 GO:0046686 response to cadmium ion(GO:0046686)
0.6 2.5 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.6 10.1 GO:0042724 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.6 3.1 GO:0000023 maltose metabolic process(GO:0000023)
0.6 1.2 GO:0042816 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.6 4.2 GO:0006007 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
0.6 2.4 GO:0060194 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.6 3.0 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.6 3.5 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.6 1.7 GO:0071050 snoRNA polyadenylation(GO:0071050)
0.6 2.9 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.6 2.3 GO:0006598 polyamine catabolic process(GO:0006598)
0.6 0.6 GO:0071629 cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071629)
0.6 4.4 GO:0051177 meiotic sister chromatid cohesion(GO:0051177)
0.5 1.1 GO:0019627 urea metabolic process(GO:0019627) urea catabolic process(GO:0043419)
0.5 2.6 GO:0034487 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.5 7.3 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.5 2.0 GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931)
0.5 5.1 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.5 2.5 GO:0044070 regulation of anion transport(GO:0044070)
0.5 1.9 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.5 1.5 GO:0015888 thiamine transport(GO:0015888)
0.5 1.9 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.5 5.1 GO:0015696 ammonium transport(GO:0015696)
0.5 1.4 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.4 1.8 GO:0051303 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.4 1.8 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.4 3.5 GO:0006119 oxidative phosphorylation(GO:0006119)
0.4 1.3 GO:0019320 hexose catabolic process(GO:0019320)
0.4 5.2 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.4 4.3 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.4 3.0 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.4 5.4 GO:0008645 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.4 1.2 GO:0043335 protein unfolding(GO:0043335)
0.4 1.1 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.3 1.3 GO:0000752 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.3 2.8 GO:0071709 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.3 1.6 GO:0008053 mitochondrial fusion(GO:0008053)
0.3 0.6 GO:0019748 secondary metabolic process(GO:0019748)
0.3 0.6 GO:0015886 heme transport(GO:0015886)
0.3 0.8 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.3 2.2 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.3 1.1 GO:0090294 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
0.3 6.7 GO:0042493 response to drug(GO:0042493)
0.3 1.3 GO:0006662 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.3 1.3 GO:0046461 triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)
0.3 1.0 GO:1903513 retrograde protein transport, ER to cytosol(GO:0030970) endoplasmic reticulum to cytosol transport(GO:1903513)
0.3 5.4 GO:0016579 protein deubiquitination(GO:0016579)
0.3 0.5 GO:1905038 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.3 0.8 GO:0071456 cellular response to hypoxia(GO:0071456)
0.2 1.7 GO:0000103 sulfate assimilation(GO:0000103)
0.2 0.2 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.2 4.9 GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress(GO:0036003)
0.2 0.7 GO:0046058 cAMP metabolic process(GO:0046058)
0.2 0.7 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.2 1.6 GO:0009098 leucine biosynthetic process(GO:0009098)
0.2 1.4 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.2 1.2 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.2 1.1 GO:0000255 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256) cellular amide catabolic process(GO:0043605)
0.2 0.2 GO:0001666 response to hypoxia(GO:0001666)
0.2 5.2 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.2 1.3 GO:0098743 aggregation of unicellular organisms(GO:0098630) cell aggregation(GO:0098743)
0.2 0.8 GO:0015793 glycerol transport(GO:0015793)
0.2 0.2 GO:0071322 cellular response to carbohydrate stimulus(GO:0071322)
0.2 2.6 GO:0046834 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.2 0.8 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.2 0.2 GO:0019566 arabinose metabolic process(GO:0019566) arabinose catabolic process(GO:0019568)
0.2 6.6 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.2 1.1 GO:0006279 premeiotic DNA replication(GO:0006279)
0.2 0.4 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491)
0.2 0.7 GO:0051865 protein autoubiquitination(GO:0051865)
0.2 1.1 GO:0018202 peptidyl-histidine modification(GO:0018202)
0.2 0.5 GO:0071248 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to metal ion(GO:0071248) cellular response to iron ion(GO:0071281)
0.2 0.5 GO:0006311 meiotic gene conversion(GO:0006311)
0.2 0.6 GO:0034503 protein localization to nucleolar rDNA repeats(GO:0034503)
0.2 1.1 GO:0032447 protein urmylation(GO:0032447)
0.2 0.5 GO:0035459 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.1 0.4 GO:0032077 positive regulation of deoxyribonuclease activity(GO:0032077) positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.1 0.3 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.1 0.3 GO:0000019 regulation of mitotic recombination(GO:0000019)
0.1 0.5 GO:0072337 modified amino acid transport(GO:0072337)
0.1 0.3 GO:0061188 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.1 1.0 GO:0045332 phospholipid translocation(GO:0045332)
0.1 0.8 GO:0010388 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.1 0.3 GO:0051098 regulation of binding(GO:0051098)
0.1 0.5 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 0.2 GO:0016320 endoplasmic reticulum membrane fusion(GO:0016320)
0.1 0.5 GO:0051126 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) negative regulation of actin nucleation(GO:0051126)
0.1 1.1 GO:0043486 histone exchange(GO:0043486)
0.1 0.3 GO:0006827 high-affinity iron ion transmembrane transport(GO:0006827)
0.1 1.1 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.1 2.2 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 0.1 GO:0042732 D-xylose metabolic process(GO:0042732)
0.1 1.1 GO:0001101 response to acid chemical(GO:0001101)
0.1 0.5 GO:0070941 eisosome assembly(GO:0070941)
0.1 0.1 GO:0030048 actin filament-based movement(GO:0030048) actin filament-based transport(GO:0099515)
0.1 1.4 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 0.9 GO:0015802 basic amino acid transport(GO:0015802)
0.1 0.3 GO:0000272 polysaccharide catabolic process(GO:0000272)
0.1 0.4 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 0.1 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.1 1.1 GO:0000742 karyogamy involved in conjugation with cellular fusion(GO:0000742)
0.1 0.3 GO:0031111 negative regulation of microtubule depolymerization(GO:0007026) negative regulation of microtubule polymerization or depolymerization(GO:0031111) regulation of microtubule depolymerization(GO:0031114)
0.1 0.8 GO:0051181 cofactor transport(GO:0051181)
0.1 0.8 GO:0000209 protein polyubiquitination(GO:0000209)
0.1 0.7 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.1 0.2 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.1 0.1 GO:0042148 strand invasion(GO:0042148)
0.1 1.9 GO:0006312 mitotic recombination(GO:0006312)
0.1 0.1 GO:1900544 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.1 0.3 GO:0072485 cellular response to biotic stimulus(GO:0071216) response to cell cycle checkpoint signaling(GO:0072396) response to mitotic cell cycle checkpoint signaling(GO:0072414) response to spindle checkpoint signaling(GO:0072417) response to mitotic spindle checkpoint signaling(GO:0072476) response to mitotic cell cycle spindle assembly checkpoint signaling(GO:0072479) response to spindle assembly checkpoint signaling(GO:0072485) negative regulation of protein import into nucleus during spindle assembly checkpoint(GO:1901925)
0.1 0.7 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.1 1.0 GO:0030474 spindle pole body duplication(GO:0030474)
0.1 0.2 GO:0036257 multivesicular body organization(GO:0036257)
0.1 0.4 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.1 0.4 GO:0000266 mitochondrial fission(GO:0000266)
0.1 2.5 GO:0071940 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
0.1 0.3 GO:0031134 sister chromatid biorientation(GO:0031134)
0.1 0.6 GO:0070987 error-free translesion synthesis(GO:0070987)
0.1 0.5 GO:0040001 establishment of mitotic spindle orientation(GO:0000132) establishment of mitotic spindle localization(GO:0040001) establishment of spindle orientation(GO:0051294)
0.1 0.2 GO:0032370 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.0 0.1 GO:0070475 rRNA base methylation(GO:0070475)
0.0 0.1 GO:0006545 glycine biosynthetic process(GO:0006545) threonine catabolic process(GO:0006567)
0.0 1.7 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 0.2 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.6 GO:0015918 sterol transport(GO:0015918)
0.0 0.5 GO:0042026 protein refolding(GO:0042026)
0.0 1.9 GO:0007031 peroxisome organization(GO:0007031)
0.0 0.1 GO:0031055 chromatin remodeling at centromere(GO:0031055)
0.0 0.6 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.0 0.7 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.0 0.2 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 0.4 GO:0043409 negative regulation of MAPK cascade(GO:0043409)
0.0 0.5 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 2.5 GO:0000122 negative regulation of transcription from RNA polymerase II promoter(GO:0000122)
0.0 0.1 GO:0007007 inner mitochondrial membrane organization(GO:0007007)
0.0 0.8 GO:0098660 inorganic ion transmembrane transport(GO:0098660)
0.0 0.6 GO:0030866 cortical cytoskeleton organization(GO:0030865) cortical actin cytoskeleton organization(GO:0030866)
0.0 0.1 GO:0051180 vitamin transport(GO:0051180)
0.0 0.2 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.0 0.1 GO:0042407 cristae formation(GO:0042407)
0.0 0.1 GO:0032978 protein insertion into membrane from inner side(GO:0032978) protein insertion into mitochondrial membrane from inner side(GO:0032979)
0.0 0.1 GO:0051292 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.0 0.2 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.0 0.1 GO:0030100 regulation of endocytosis(GO:0030100)
0.0 0.1 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196) peptidyl-methionine modification(GO:0018206)
0.0 0.1 GO:0030149 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.0 0.3 GO:0008219 apoptotic process(GO:0006915) cell death(GO:0008219) programmed cell death(GO:0012501)
0.0 0.7 GO:0006626 protein targeting to mitochondrion(GO:0006626)
0.0 0.1 GO:0015846 polyamine transport(GO:0015846)
0.0 0.2 GO:0019318 hexose metabolic process(GO:0019318)
0.0 0.1 GO:0006301 postreplication repair(GO:0006301)
0.0 0.0 GO:0019933 cAMP-mediated signaling(GO:0019933) cyclic-nucleotide-mediated signaling(GO:0019935)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 14.8 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
2.3 9.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)
2.0 6.1 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
1.5 32.5 GO:0070469 respiratory chain(GO:0070469)
1.4 4.3 GO:0045265 mitochondrial proton-transporting ATP synthase, stator stalk(GO:0000274) proton-transporting ATP synthase, stator stalk(GO:0045265)
1.4 5.7 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
1.4 5.7 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
1.4 5.5 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
1.1 3.4 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
1.1 3.2 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.8 2.5 GO:0046930 pore complex(GO:0046930)
0.8 3.2 GO:0030287 cell wall-bounded periplasmic space(GO:0030287)
0.8 3.2 GO:0042597 periplasmic space(GO:0042597)
0.7 4.3 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.7 5.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.6 2.4 GO:0097042 extrinsic component of fungal-type vacuolar membrane(GO:0097042)
0.5 6.4 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259)
0.5 6.7 GO:0005619 ascospore wall(GO:0005619)
0.5 8.2 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.5 3.5 GO:0034967 Set3 complex(GO:0034967)
0.5 2.5 GO:0032221 Rpd3S complex(GO:0032221)
0.5 8.2 GO:0031307 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.5 2.3 GO:0072379 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.4 3.0 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.4 56.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.3 2.7 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.3 1.0 GO:0005784 Sec61 translocon complex(GO:0005784)
0.3 3.1 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.3 1.3 GO:0033309 SBF transcription complex(GO:0033309)
0.3 2.3 GO:0034657 GID complex(GO:0034657)
0.3 0.6 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.3 0.6 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.3 0.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.3 6.1 GO:0070847 core mediator complex(GO:0070847)
0.3 9.7 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.3 0.9 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)
0.3 3.8 GO:0000812 Swr1 complex(GO:0000812)
0.3 11.6 GO:0031225 anchored component of membrane(GO:0031225)
0.2 2.0 GO:0098552 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.2 4.3 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.2 3.5 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.2 2.2 GO:0000974 Prp19 complex(GO:0000974)
0.2 0.6 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.2 1.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.2 0.6 GO:0033551 monopolin complex(GO:0033551)
0.2 0.5 GO:0033186 CAF-1 complex(GO:0033186)
0.2 3.3 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.1 3.7 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 2.6 GO:0098798 mitochondrial protein complex(GO:0098798)
0.1 0.4 GO:0032177 split septin rings(GO:0032176) cellular bud neck split septin rings(GO:0032177)
0.1 0.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 0.1 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.1 0.8 GO:0008180 COP9 signalosome(GO:0008180)
0.1 0.4 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 2.8 GO:0031226 intrinsic component of plasma membrane(GO:0031226)
0.1 0.7 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.1 1.4 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1 0.4 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.1 0.5 GO:0005869 dynactin complex(GO:0005869)
0.1 1.9 GO:0000124 SAGA complex(GO:0000124)
0.1 0.6 GO:0016272 prefoldin complex(GO:0016272)
0.1 10.5 GO:0098852 fungal-type vacuole membrane(GO:0000329) lytic vacuole membrane(GO:0098852)
0.1 0.4 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) nucleoplasmic THO complex(GO:0000446)
0.1 0.4 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 0.3 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.1 0.7 GO:0033698 Rpd3L complex(GO:0033698)
0.1 0.5 GO:0048188 histone methyltransferase complex(GO:0035097) Set1C/COMPASS complex(GO:0048188)
0.1 0.1 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.1 0.2 GO:0032301 MutSalpha complex(GO:0032301)
0.1 39.3 GO:0005739 mitochondrion(GO:0005739)
0.1 0.4 GO:0098797 plasma membrane protein complex(GO:0098797)
0.0 0.2 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.8 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.1 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.0 1.1 GO:0000780 condensed nuclear chromosome, centromeric region(GO:0000780)
0.0 0.3 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 0.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.1 GO:0000839 Hrd1p ubiquitin ligase complex(GO:0000836) Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.1 GO:0005686 U2 snRNP(GO:0005686)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.2 18.5 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
3.4 10.2 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
3.0 14.8 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
2.9 8.7 GO:0003954 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
2.4 7.3 GO:0005536 glucose binding(GO:0005536)
2.3 9.3 GO:0004396 hexokinase activity(GO:0004396)
1.9 7.5 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
1.9 5.6 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
1.8 5.5 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
1.8 5.3 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
1.7 6.9 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
1.7 10.0 GO:0090599 alpha-glucosidase activity(GO:0090599)
1.6 4.8 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
1.5 6.2 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
1.5 4.5 GO:0016289 CoA hydrolase activity(GO:0016289)
1.5 6.0 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
1.4 5.7 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
1.4 11.3 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
1.3 3.9 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
1.3 3.8 GO:0004866 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
1.1 3.3 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
1.1 3.2 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
1.1 5.3 GO:0004075 biotin carboxylase activity(GO:0004075)
1.0 4.0 GO:0015295 solute:proton symporter activity(GO:0015295)
1.0 4.9 GO:0008198 ferrous iron binding(GO:0008198)
0.9 10.3 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.9 2.8 GO:0008902 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.8 10.9 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.8 2.5 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.8 2.5 GO:0008308 anion channel activity(GO:0005253) voltage-gated anion channel activity(GO:0008308) porin activity(GO:0015288) wide pore channel activity(GO:0022829)
0.8 8.5 GO:0015293 symporter activity(GO:0015293)
0.8 13.0 GO:0046906 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.7 4.3 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.7 3.6 GO:0019212 protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
0.7 4.8 GO:0008379 thioredoxin peroxidase activity(GO:0008379) peroxiredoxin activity(GO:0051920)
0.6 3.2 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.6 7.0 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.6 11.4 GO:0016831 carboxy-lyase activity(GO:0016831)
0.6 10.4 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.6 3.6 GO:0000400 four-way junction DNA binding(GO:0000400)
0.6 2.3 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.6 2.2 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.5 3.0 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.5 3.5 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.5 4.9 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.5 1.5 GO:0015188 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.5 1.9 GO:0005537 mannose binding(GO:0005537)
0.5 2.3 GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)(GO:0097372)
0.4 1.3 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.4 0.4 GO:0032451 demethylase activity(GO:0032451) histone demethylase activity(GO:0032452)
0.4 1.7 GO:0008169 C-methyltransferase activity(GO:0008169)
0.4 10.4 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.4 5.1 GO:0005199 structural constituent of cell wall(GO:0005199)
0.4 2.6 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.4 1.7 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.4 3.0 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.4 2.5 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.4 3.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.4 0.8 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.4 1.9 GO:0019104 DNA N-glycosylase activity(GO:0019104)
0.4 1.8 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.4 3.7 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.4 1.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.4 1.1 GO:0016405 CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
0.3 1.7 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.3 4.7 GO:0005353 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.3 5.6 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.3 2.7 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.3 5.7 GO:0008301 DNA binding, bending(GO:0008301)
0.3 0.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.3 3.2 GO:0004888 transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) transmembrane receptor activity(GO:0099600)
0.3 2.9 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.3 0.8 GO:0017136 NAD-dependent histone deacetylase activity(GO:0017136) NAD-dependent protein deacetylase activity(GO:0034979)
0.3 0.8 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.3 1.3 GO:0004806 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.3 1.5 GO:0015038 peptide disulfide oxidoreductase activity(GO:0015037) glutathione disulfide oxidoreductase activity(GO:0015038)
0.2 0.2 GO:0015151 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.2 0.7 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.2 4.4 GO:0004221 obsolete ubiquitin thiolesterase activity(GO:0004221)
0.2 0.7 GO:0016783 transferase activity, transferring sulfur-containing groups(GO:0016782) sulfurtransferase activity(GO:0016783)
0.2 9.4 GO:0001228 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.2 0.6 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.2 1.7 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.2 1.7 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.2 1.0 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.2 2.3 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.2 0.9 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.2 1.5 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.2 0.7 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.2 0.9 GO:0004559 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.2 0.3 GO:0035591 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.2 0.8 GO:0030246 carbohydrate binding(GO:0030246)
0.2 3.5 GO:0003684 damaged DNA binding(GO:0003684)
0.1 0.7 GO:0001129 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132)
0.1 2.4 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.1 1.0 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 0.3 GO:0001026 transcription factor activity, core RNA polymerase III binding(GO:0000995) TFIIIB-type transcription factor activity(GO:0001026)
0.1 6.3 GO:0005096 GTPase activator activity(GO:0005096)
0.1 2.5 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 0.6 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.1 0.8 GO:0051184 cofactor transporter activity(GO:0051184)
0.1 0.6 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.1 0.4 GO:0016531 copper chaperone activity(GO:0016531)
0.1 1.2 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.1 1.2 GO:0016209 antioxidant activity(GO:0016209)
0.1 1.0 GO:0032947 protein complex scaffold(GO:0032947)
0.1 0.4 GO:0005102 receptor binding(GO:0005102)
0.1 0.7 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.1 0.9 GO:0031369 translation initiation factor binding(GO:0031369)
0.1 2.4 GO:0061733 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.1 0.2 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 0.9 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 0.2 GO:1901474 azole transmembrane transporter activity(GO:1901474)
0.1 0.3 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 5.8 GO:0051082 unfolded protein binding(GO:0051082)
0.1 0.7 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.1 0.4 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.1 0.5 GO:0035064 methylated histone binding(GO:0035064)
0.1 0.4 GO:0003993 acid phosphatase activity(GO:0003993)
0.1 0.3 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.1 1.5 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 4.7 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.1 0.5 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.1 1.4 GO:0016410 N-acyltransferase activity(GO:0016410)
0.1 0.5 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 1.5 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.1 0.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 0.4 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 1.8 GO:0022890 inorganic cation transmembrane transporter activity(GO:0022890)
0.0 0.1 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.0 0.1 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 0.2 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.1 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.7 GO:0004857 enzyme inhibitor activity(GO:0004857)
0.0 1.1 GO:0003678 DNA helicase activity(GO:0003678)
0.0 0.1 GO:0004180 carboxypeptidase activity(GO:0004180)
0.0 0.3 GO:0004407 histone deacetylase activity(GO:0004407) protein deacetylase activity(GO:0033558)
0.0 0.1 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.0 0.1 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.0 0.8 GO:0015291 secondary active transmembrane transporter activity(GO:0015291)
0.0 0.5 GO:0016769 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.0 1.4 GO:0022804 active transmembrane transporter activity(GO:0022804)
0.0 0.3 GO:0000149 SNARE binding(GO:0000149)
0.0 0.5 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.4 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.3 GO:0008374 O-acyltransferase activity(GO:0008374)
0.0 0.4 GO:0019900 kinase binding(GO:0019900) protein kinase binding(GO:0019901)
0.0 0.5 GO:0034062 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 8.9 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
1.1 3.4 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.4 1.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4 1.1 PID IL4 2PATHWAY IL4-mediated signaling events
0.3 1.0 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.3 2.4 PID FANCONI PATHWAY Fanconi anemia pathway
0.2 0.7 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.2 0.6 PID NOTCH PATHWAY Notch signaling pathway
0.1 0.3 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 0.1 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.1 0.2 PID CMYB PATHWAY C-MYB transcription factor network
0.1 0.2 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 69.4 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.1 PID ATF2 PATHWAY ATF-2 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 8.2 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
1.8 16.6 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
1.4 4.2 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.3 0.9 REACTOME PI3K EVENTS IN ERBB2 SIGNALING Genes involved in PI3K events in ERBB2 signaling
0.2 0.7 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.2 0.7 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 0.1 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.2 REACTOME HEMOSTASIS Genes involved in Hemostasis
0.0 63.8 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.0 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression