Results for MSN2
Z-value: 0.88
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Transcription factors associated with MSN2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
MSN2
|
S000004640 | Transcriptional activator |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YNR034W-A Show fit | 14.31 |
Putative protein of unknown function; expression is regulated by Msn2p/Msn4p |
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| YFR053C Show fit | 12.37 |
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p |
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| YMR175W Show fit | 11.62 |
Protein of unknown function whose expression is induced by osmotic stress |
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| YOL052C-A Show fit | 11.27 |
Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses |
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| YKL217W Show fit | 10.04 |
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose |
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| YMR105C Show fit | 8.64 |
Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase |
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| YEL039C Show fit | 8.60 |
Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration |
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| YBR072W Show fit | 8.13 |
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells |
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| YER150W Show fit | 7.96 |
GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p |
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| YLR312C Show fit | 7.93 |
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity |
Network of associatons between targets according to the STRING database.
First level regulatory network of MSN2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 19.1 | GO:0005978 | glycogen biosynthetic process(GO:0005978) |
| 0.8 | 16.1 | GO:0008645 | hexose transport(GO:0008645) monosaccharide transport(GO:0015749) |
| 1.5 | 14.9 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 3.2 | 12.9 | GO:0006848 | pyruvate transport(GO:0006848) |
| 4.2 | 12.7 | GO:0015755 | fructose transport(GO:0015755) |
| 3.0 | 12.1 | GO:0071462 | response to water(GO:0009415) cellular response to water stimulus(GO:0071462) |
| 2.4 | 12.0 | GO:0005980 | glycogen catabolic process(GO:0005980) |
| 0.7 | 10.8 | GO:0006754 | ATP biosynthetic process(GO:0006754) |
| 0.2 | 10.6 | GO:0009060 | aerobic respiration(GO:0009060) |
| 1.2 | 9.8 | GO:0006097 | glyoxylate cycle(GO:0006097) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 74.8 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.2 | 26.5 | GO:0000322 | storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324) |
| 0.2 | 17.7 | GO:0005576 | extracellular region(GO:0005576) |
| 0.2 | 9.7 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.5 | 9.6 | GO:0031307 | intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307) |
| 3.1 | 9.2 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.6 | 8.0 | GO:0070469 | respiratory chain(GO:0070469) |
| 1.6 | 7.9 | GO:0005749 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
| 0.9 | 7.7 | GO:0000328 | fungal-type vacuole lumen(GO:0000328) |
| 0.9 | 6.9 | GO:0042597 | periplasmic space(GO:0042597) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 24.8 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.9 | 15.8 | GO:0046906 | heme binding(GO:0020037) tetrapyrrole binding(GO:0046906) |
| 3.7 | 14.9 | GO:0004396 | hexokinase activity(GO:0004396) |
| 3.0 | 14.8 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 0.9 | 12.3 | GO:0005353 | fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578) |
| 0.4 | 11.3 | GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553) |
| 0.8 | 10.0 | GO:0035251 | UDP-glucosyltransferase activity(GO:0035251) |
| 3.1 | 9.2 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 2.1 | 8.3 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
| 1.6 | 7.9 | GO:0008177 | succinate dehydrogenase (ubiquinone) activity(GO:0008177) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 43.8 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 3.0 | 9.0 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.7 | 2.0 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.4 | 2.0 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.5 | 1.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.4 | 1.1 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.3 | 1.0 | PID FOXO PATHWAY | FoxO family signaling |
| 0.1 | 0.6 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 0.4 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 0.2 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 40.6 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 1.5 | 16.7 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |
| 1.0 | 3.1 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.6 | 1.7 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.1 | 0.7 | REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM | Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism |
| 0.1 | 0.4 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.0 | 0.4 | REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS | Genes involved in Metabolism of lipids and lipoproteins |
| 0.0 | 0.3 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.0 | 0.3 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 0.1 | REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE | Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle |