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Results for MSN2

Z-value: 0.88

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Transcription factors associated with MSN2

Gene Symbol Gene ID Gene Info
MSN2
S000004640 Transcriptional activator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MSN2YMR037C-0.271.9e-01Click!

Activity profile of MSN2 motif

Sorted Z-values of MSN2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YNR034W-A 14.31 Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YFR053C 12.37
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YMR175W 11.62
SIP18
Protein of unknown function whose expression is induced by osmotic stress
YOL052C-A 11.27
DDR2
Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses
YKL217W 10.04
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YMR105C 8.64
PGM2
Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase
YEL039C 8.60
CYC7
Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YBR072W 8.13
HSP26
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YER150W 7.96
SPI1
GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YLR312C 7.93
QNQ1
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YHR092C 7.61
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YOR393W 7.21
ERR1
Protein of unknown function, has similarity to enolases
YMR206W 7.07 Putative protein of unknown function; YMR206W is not an essential gene
YHL021C 6.54
AIM17
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YDR343C 6.52
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YER103W 5.97
SSA4
Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation
YER067W 5.87 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YER067W is not an essential gene
YAL061W 5.48
BDH2
Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; BDH2 is an essential gene
YGR087C 5.31
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YNL117W 5.31
MLS1
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YOL084W 5.29
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YHR096C 5.22
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YPR160W 5.11
GPH1
Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
YBR201C-A 5.05 Putative protein of unknown function
YDR171W 4.97
HSP42
Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock
YOR100C 4.86
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YAR053W 4.86 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR169C 4.85
ALD3
Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose
YFR017C 4.82 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene
YKL163W 4.74
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YEL011W 4.66
GLC3
Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YBL015W 4.62
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YCR021C 4.61
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YAR060C 4.54 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIL162W 4.37
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YMR174C 4.30
PAI3
Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact
YLR149C 4.27 Putative protein of unknown function; YLR149C is not an essential gene
YFR015C 4.20
GSY1
Glycogen synthase with similarity to Gsy2p, the more highly expressed yeast homolog; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase
YIL136W 4.18
OM45
Protein of unknown function, major constituent of the mitochondrial outer membrane; located on the outer (cytosolic) face of the outer membrane
YPL247C 4.14 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; YPL247C is not an essential gene
YLR377C 4.12
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YNL194C 4.08 Integral membrane protein localized to eisosomes; sporulation and plasma membrane sphingolipid content are altered in mutants; has homologs SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YPL054W 4.06
LEE1
Zinc-finger protein of unknown function
YDL210W 4.06
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YDR258C 4.05
HSP78
Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; prevents the aggregation of misfolded matrix proteins; component of the mitochondrial proteolysis system
YDR277C 3.99
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YMR081C 3.96
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YBL049W 3.94
MOH1
Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase
YGR088W 3.93
CTT1
Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YJR115W 3.86 Putative protein of unknown function
YPR184W 3.78
GDB1
Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria
YHR087W 3.65
RTC3
Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity
YHR139C 3.65
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YMR107W 3.63
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YLL026W 3.63
HSP104
Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation
YOR391C 3.62
HSP33
Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease
YPL036W 3.60
PMA2
Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
YGR201C 3.56 Putative protein of unknown function
YAL034C 3.53
FUN19
Non-essential protein of unknown function
YBR183W 3.52
YPC1
Alkaline ceramidase that also has reverse (CoA-independent) ceramide synthase activity, catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance
YML100W 3.48
TSL1
Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose, homologous to Tps3p and may share function
YDR342C 3.39
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YBR147W 3.38
RTC2
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays fluconazole resistance and suppresses cdc13-1 temperature sensitivity
YAR050W 3.35
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YHR212C 3.33 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR070W 3.26
ROM1
GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
YJL089W 3.25
SIP4
C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus
YAL039C 3.24
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YPR026W 3.23
ATH1
Acid trehalase required for utilization of extracellular trehalose
YKL026C 3.22
GPX1
Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YPR010C-A 3.19 Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YIL099W 3.15
SGA1
Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
YOL154W 3.12
ZPS1
Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
YMR251W 3.10
GTO3
Omega class glutathione transferase; putative cytosolic localization
YNL093W 3.06
YPT53
GTPase, similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis
YDL204W 3.05
RTN2
Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily
YEL008W 3.03 Hypothetical protein predicted to be involved in metabolism
YKL148C 3.02
SDH1
Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YKL093W 3.01
MBR1
Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants
YPL240C 3.01
HSP82
Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
YAR047C 2.98 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR214W 2.96
SDS24
One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein, which genetic studies have implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis
YER065C 2.89
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YIL045W 2.84
PIG2
Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase
YGR243W 2.84
FMP43
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR348C 2.84
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YNL305C 2.83 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL305C is not an essential gene
YLR258W 2.83
GSY2
Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase
YHR212W-A 2.82 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YHR138C 2.76 Putative protein of unknown function; has similarity to Pbi2p; double null mutant lacking Pbi2p and Yhr138p exhibits highly fragmented vacuoles
YOL082W 2.75
ATG19
Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; recognizes cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) and delivers them to the preautophagosomal structure for packaging into Cvt vesicles
YDR234W 2.67
LYS4
Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway
YDR516C 2.61
EMI2
Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression is regulated by glucose-repression transcription factors Mig1/2p
YDR178W 2.60
SDH4
Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YML128C 2.59
MSC1
Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated
YJL045W 2.59 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YJL067W 2.57 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR096W 2.56 Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YGR067C 2.54 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YOR285W 2.53 Protein of unknown function, localized to the mitochondrial outer membrane
YPL271W 2.51
ATP15
Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YAL005C 2.49
SSA1
ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall
YJL141C 2.48
YAK1
Serine-threonine protein kinase that is part of a glucose-sensing system involved in growth control in response to glucose availability; translocates from the cytoplasm to the nucleus and phosphorylates Pop2p in response to a glucose signal
YGR069W 2.47 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR178C 2.47
GAC1
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YPR027C 2.46 Putative protein of unknown function
YOR173W 2.45
DCS2
Non-essential, stress induced regulatory protein containing a HIT (histidine triad) motif; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway, similar to Dcs1p.
YOL118C 2.40 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YPL186C 2.37
UIP4
Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope
YOR120W 2.37
GCY1
Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family
YBR117C 2.37
TKL2
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YNL055C 2.36
POR1
Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated
YEL009C 2.33
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YJL103C 2.31
GSM1
Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis
YHL040C 2.31
ARN1
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores
YDL130W-A 2.31
STF1
Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein
YFL054C 2.29 Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol
YOL119C 2.29
MCH4
Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YFL030W 2.28
AGX1
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YMR181C 2.26 Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); YMR181C is not an essential gene
YML120C 2.26
NDI1
NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID
YOR392W 2.24 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; gene expression induced by heat
YPL017C 2.23
IRC15
Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family, required for accurate meiotic chromosome segregation; null mutant displays increased levels of spontaneous Rad52 foci
YMR250W 2.23
GAD1
Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress
YFL052W 2.22 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YLL041C 2.22
SDH2
Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YAL062W 2.21
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YPL185W 2.20 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
YGR248W 2.19
SOL4
6-phosphogluconolactonase with similarity to Sol3p
YHR001W-A 2.18
QCR10
Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain
YGR144W 2.17
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YDR096W 2.16
GIS1
JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1
YJR146W 2.14 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2
YPL230W 2.11
USV1
Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in protein folding, ATP binding, and cell wall biosynthesis
YOR374W 2.11
ALD4
Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
YMR297W 2.09
PRC1
Vacuolar carboxypeptidase Y (proteinase C), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family
YKL085W 2.07
MDH1
Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated
YJL066C 2.07
MPM1
Mitochondrial membrane protein of unknown function, contains no hydrophobic stretches
YOR049C 2.06
RSB1
Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
YBR269C 2.05
FMP21
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLL053C 2.04 Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YGR254W 2.02
ENO1
Enolase I, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose
YKL109W 2.02
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YIL066C 2.01
RNR3
One of two large regulatory subunits of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits
YNL077W 1.99
APJ1
Putative chaperone of the HSP40 (DNAJ) family; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YFL058W 1.97
THI5
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YKR066C 1.95
CCP1
Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress
YDL214C 1.95
PRR2
Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
YIL101C 1.94
XBP1
Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate
YML089C 1.94 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YLR178C 1.94
TFS1
Carboxypeptidase Y inhibitor, function requires acetylation by the NatB N-terminal acetyltransferase; phosphatidylethanolamine-binding protein involved in protein kinase A signaling pathway
YJL144W 1.94 Cytoplasmic hydrophilin of unknown function, possibly involved in the dessication response; expression induced by osmotic stress, starvation and during stationary phase; GFP-fusion protein is induced by the DNA-damaging agent MMS
YOR382W 1.90
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YPR196W 1.90 Putative maltose activator
YPL229W 1.90 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL229W is not an essential gene
YOR066W 1.89
MSA1
Activator of G1-specific transcription factors, MBF and SBF, that regulates both the timing of G1-specific gene transcription, and cell cycle initiation; potential Cdc28p substrate
YEL070W 1.87
DSF1
Deletion suppressor of mpt5 mutation
YGL104C 1.86
VPS73
Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family
YOR186W 1.86 Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent
YDR070C 1.84
FMP16
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR294C 1.84 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14
YKR049C 1.83
FMP46
Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBL078C 1.83
ATG8
Conserved protein that is a component of autophagosomes and Cvt vesicles; undergoes C-terminal conjugation to phosphatidylethanolamine (PE), Atg8p-PE is anchored to membranes and may mediate membrane fusion during autophagosome formation
YIR039C 1.83
YPS6
Putative GPI-anchored aspartic protease
YGL045W 1.82
RIM8
Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF
YDL169C 1.82
UGX2
Protein of unknown function, transcript accumulates in response to any combination of stress conditions
YGR194C 1.81
XKS1
Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains
YHR104W 1.81
GRE3
Aldose reductase involved in methylglyoxal, d-xylose and arabinose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway
YLL052C 1.80
AQY2
Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YBR132C 1.78
AGP2
High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease
YDR119W-A 1.78 Putative protein of unknown function
YIL122W 1.78
POG1
Putative transcriptional activator that promotes recovery from pheromone induced arrest; inhibits both alpha-factor induced G1 arrest and repression of CLN1 and CLN2 via SCB/MCB promoter elements; potential Cdc28p substrate; SBF regulated
YDL181W 1.78
INH1
Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has similarity to Stf1p; has a calmodulin-binding motif and binds calmodulin in vitro
YIR027C 1.78
DAL1
Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression
YJR008W 1.75 Putative protein of unknown function; expression repressed by inosine and choline in an Opi1p-dependent manner; expression induced by mild heat-stress on a non-fermentable carbon source.
YDR018C 1.73 Probable membrane protein with three predicted transmembrane domains; homologous to Ybr042cp, similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; null exhibits no apparent phenotype
YGR236C 1.72
SPG1
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNR001C 1.72
CIT1
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein
YAL060W 1.72
BDH1
NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source
YIL057C 1.72 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YPR036W-A 1.71 Protein of unknown function; transcription is regulated by Pdr1p
YPL092W 1.71
SSU1
Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein
YFR022W 1.70
ROG3
Protein that binds to Rsp5p, which is a hect-type ubiquitin ligase, via its 2 PY motifs; has similarity to Rod1p; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant
YBL064C 1.69
PRX1
Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress; phosphorylated
YLR201C 1.69
COQ9
Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
YER088C 1.67
DOT6
Protein of unknown function, involved in telomeric gene silencing and filamentation
YNL190W 1.66 Cell wall protein of unknown function; proposed role as a hydrophilin induced by osmotic stress; contains a putative GPI-attachment site
YOL047C 1.66 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YKL067W 1.64
YNK1
Nucleoside diphosphate kinase, catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate
YPL006W 1.63
NCR1
Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein
YOR065W 1.63
CYT1
Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
YNL322C 1.63
KRE1
Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
YLR080W 1.62
EMP46
Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
YLL055W 1.62
YCT1
High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
YHL024W 1.61
RIM4
Putative RNA-binding protein required for the expression of early and middle sporulation genes
YCL048W-A 1.61 Putative protein of unknown function
YMR280C 1.59
CAT8
Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements
YER066C-A 1.59 Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W
YDR032C 1.59
PST2
Protein with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDL004W 1.58
ATP16
Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated

Network of associatons between targets according to the STRING database.

First level regulatory network of MSN2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 12.7 GO:0015755 fructose transport(GO:0015755)
3.2 12.9 GO:0006848 pyruvate transport(GO:0006848)
3.0 12.1 GO:0071462 response to water(GO:0009415) cellular response to water stimulus(GO:0071462)
2.9 8.7 GO:0032780 negative regulation of ATPase activity(GO:0032780)
2.9 8.7 GO:0043335 protein unfolding(GO:0043335)
2.5 7.4 GO:0010466 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
2.4 12.0 GO:0005980 glycogen catabolic process(GO:0005980)
2.1 8.3 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
2.0 5.9 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
1.7 5.0 GO:0046466 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
1.6 4.8 GO:0035948 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
1.6 7.9 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
1.5 4.6 GO:0005993 trehalose catabolic process(GO:0005993)
1.5 14.9 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
1.4 4.2 GO:0042843 D-xylose catabolic process(GO:0042843)
1.4 5.5 GO:0006598 polyamine catabolic process(GO:0006598)
1.3 19.1 GO:0005978 glycogen biosynthetic process(GO:0005978)
1.2 9.8 GO:0006097 glyoxylate cycle(GO:0006097)
1.2 4.7 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
1.1 3.2 GO:0017003 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
1.1 3.2 GO:0090630 activation of GTPase activity(GO:0090630)
1.0 4.1 GO:0015804 neutral amino acid transport(GO:0015804)
1.0 1.9 GO:0042732 D-xylose metabolic process(GO:0042732)
0.9 4.7 GO:0034486 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.9 8.5 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.9 5.3 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.9 2.6 GO:0006740 NADPH regeneration(GO:0006740)
0.8 3.4 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.8 3.4 GO:0015847 putrescine transport(GO:0015847)
0.8 2.5 GO:0006108 malate metabolic process(GO:0006108)
0.8 3.2 GO:0019748 secondary metabolic process(GO:0019748)
0.8 16.1 GO:0008645 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.8 3.8 GO:0006083 acetate metabolic process(GO:0006083)
0.8 2.3 GO:0006545 glycine biosynthetic process(GO:0006545)
0.8 2.3 GO:0043065 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.7 2.2 GO:0006538 glutamate catabolic process(GO:0006538)
0.7 0.7 GO:0097306 positive regulation of transcription from RNA polymerase II promoter in response to ethanol(GO:0061410) cellular response to ethanol(GO:0071361) cellular response to alcohol(GO:0097306)
0.7 2.2 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.7 2.9 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.7 10.8 GO:0006754 ATP biosynthetic process(GO:0006754)
0.7 5.3 GO:0005985 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.7 0.7 GO:0051222 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
0.7 2.0 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.6 1.8 GO:1903137 inactivation of MAPK activity involved in cell wall organization or biogenesis(GO:0000200) regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903137) negative regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903138) negative regulation of cell wall organization or biogenesis(GO:1903339)
0.6 3.0 GO:0043954 cellular component maintenance(GO:0043954)
0.6 2.9 GO:0019563 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.6 4.1 GO:0015891 siderophore transport(GO:0015891)
0.6 6.1 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.5 1.6 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.5 1.6 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.5 0.5 GO:0046487 glyoxylate metabolic process(GO:0046487)
0.5 4.5 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.5 1.0 GO:0001315 age-dependent response to reactive oxygen species(GO:0001315) cellular age-dependent response to reactive oxygen species(GO:0072353)
0.5 1.9 GO:0031135 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.5 2.4 GO:0046058 cAMP metabolic process(GO:0046058)
0.5 8.4 GO:0001101 response to acid chemical(GO:0001101)
0.5 1.4 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
0.5 5.1 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.4 1.3 GO:0009145 purine nucleoside triphosphate biosynthetic process(GO:0009145) purine ribonucleoside triphosphate biosynthetic process(GO:0009206)
0.4 0.9 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.4 7.1 GO:0042724 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.4 2.5 GO:0000255 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256)
0.4 1.6 GO:0006482 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.4 2.4 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.4 2.8 GO:0015908 fatty acid transport(GO:0015908)
0.4 6.6 GO:0006094 gluconeogenesis(GO:0006094)
0.4 2.3 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.4 1.9 GO:0046931 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.4 1.5 GO:0046185 aldehyde catabolic process(GO:0046185)
0.4 3.3 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.4 1.4 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.4 1.1 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.3 0.3 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.3 1.0 GO:0015976 carbon utilization(GO:0015976)
0.3 0.6 GO:0006102 isocitrate metabolic process(GO:0006102)
0.3 0.9 GO:0090295 nitrogen catabolite repression of transcription(GO:0090295)
0.3 0.9 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
0.3 0.9 GO:0045991 carbon catabolite activation of transcription(GO:0045991)
0.3 0.6 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.3 1.5 GO:0000023 maltose metabolic process(GO:0000023)
0.3 1.4 GO:0008053 mitochondrial fusion(GO:0008053)
0.3 0.8 GO:0070199 establishment of protein localization to chromosome(GO:0070199) establishment of protein localization to chromatin(GO:0071169)
0.3 2.5 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.3 1.4 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.3 1.6 GO:0010388 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.3 1.3 GO:0051654 establishment of mitochondrion localization(GO:0051654)
0.3 3.2 GO:0046686 response to cadmium ion(GO:0046686)
0.3 2.4 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.2 5.5 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.2 1.7 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.2 1.2 GO:0018904 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.2 0.5 GO:0043687 C-terminal protein amino acid modification(GO:0018410) post-translational protein modification(GO:0043687)
0.2 2.8 GO:0006165 nucleoside diphosphate phosphorylation(GO:0006165)
0.2 2.8 GO:0006749 glutathione metabolic process(GO:0006749)
0.2 0.7 GO:0032056 positive regulation of translation in response to stress(GO:0032056)
0.2 10.6 GO:0009060 aerobic respiration(GO:0009060)
0.2 1.6 GO:0006641 neutral lipid metabolic process(GO:0006638) acylglycerol metabolic process(GO:0006639) triglyceride metabolic process(GO:0006641)
0.2 0.9 GO:0032102 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.2 0.7 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.2 0.8 GO:0032373 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.2 0.2 GO:0042148 strand invasion(GO:0042148)
0.2 1.0 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.2 1.2 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.2 0.2 GO:0034503 protein localization to nucleolar rDNA repeats(GO:0034503)
0.2 0.6 GO:0009300 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.2 1.5 GO:0006119 oxidative phosphorylation(GO:0006119)
0.2 0.2 GO:0008615 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.2 2.0 GO:0016925 protein sumoylation(GO:0016925)
0.2 0.2 GO:0000304 response to singlet oxygen(GO:0000304)
0.2 1.4 GO:0019856 pyrimidine nucleobase biosynthetic process(GO:0019856)
0.2 1.7 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.2 1.0 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.2 1.8 GO:0007135 meiosis II(GO:0007135) meiotic sister chromatid segregation(GO:0045144)
0.2 3.0 GO:0006895 Golgi to endosome transport(GO:0006895)
0.2 1.7 GO:0072348 sulfur compound transport(GO:0072348)
0.1 0.4 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.1 1.1 GO:0018345 protein palmitoylation(GO:0018345)
0.1 0.3 GO:0099515 actin filament-based movement(GO:0030048) actin filament-based transport(GO:0099515)
0.1 0.9 GO:0030026 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.1 0.9 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.1 1.1 GO:0070987 error-free translesion synthesis(GO:0070987)
0.1 0.4 GO:0043096 purine nucleobase salvage(GO:0043096)
0.1 0.4 GO:0030491 heteroduplex formation(GO:0030491)
0.1 2.1 GO:0000209 protein polyubiquitination(GO:0000209)
0.1 0.4 GO:0006089 lactate metabolic process(GO:0006089)
0.1 4.6 GO:0070726 cell wall assembly(GO:0070726)
0.1 0.3 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.1 0.5 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.1 0.5 GO:0051303 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.1 2.0 GO:0032258 CVT pathway(GO:0032258)
0.1 0.5 GO:0030042 actin filament depolymerization(GO:0030042)
0.1 0.9 GO:0043488 regulation of RNA stability(GO:0043487) regulation of mRNA stability(GO:0043488)
0.1 0.4 GO:0044070 regulation of anion transport(GO:0044070)
0.1 0.8 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.1 0.9 GO:0000755 cytogamy(GO:0000755)
0.1 0.8 GO:0006829 zinc II ion transport(GO:0006829)
0.1 1.2 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.1 0.4 GO:0051260 protein homooligomerization(GO:0051260)
0.1 0.3 GO:0034395 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.1 1.7 GO:0022900 electron transport chain(GO:0022900)
0.1 0.8 GO:0006813 potassium ion transport(GO:0006813)
0.1 0.4 GO:0019346 transsulfuration(GO:0019346)
0.1 1.5 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.1 0.2 GO:0046348 aminoglycan catabolic process(GO:0006026) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.1 0.2 GO:0006311 meiotic gene conversion(GO:0006311)
0.1 0.2 GO:0008216 spermidine metabolic process(GO:0008216)
0.1 0.4 GO:0006265 DNA topological change(GO:0006265)
0.1 0.5 GO:0006855 drug transmembrane transport(GO:0006855)
0.1 0.3 GO:0055129 L-proline biosynthetic process(GO:0055129)
0.1 0.3 GO:0051101 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
0.1 0.2 GO:0019626 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
0.1 0.4 GO:0000196 MAPK cascade involved in cell wall organization or biogenesis(GO:0000196)
0.1 0.1 GO:0044247 glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.1 3.6 GO:0007031 peroxisome organization(GO:0007031)
0.1 0.3 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.1 0.9 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.1 0.4 GO:0051598 meiotic cell cycle checkpoint(GO:0033313) meiotic recombination checkpoint(GO:0051598)
0.1 0.1 GO:0045117 azole transport(GO:0045117)
0.1 1.4 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.1 1.0 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968) cellular response to unfolded protein(GO:0034620)
0.1 0.4 GO:0050821 protein stabilization(GO:0050821)
0.1 0.5 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 0.4 GO:0015851 nucleobase transport(GO:0015851)
0.1 0.4 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.1 0.1 GO:0072350 tricarboxylic acid metabolic process(GO:0072350)
0.1 1.0 GO:1903825 organic acid transmembrane transport(GO:1903825) carboxylic acid transmembrane transport(GO:1905039)
0.1 0.2 GO:0042407 cristae formation(GO:0042407)
0.1 0.1 GO:0060962 regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060962)
0.1 2.7 GO:0035825 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.1 0.4 GO:0009102 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.1 0.2 GO:0006531 aspartate metabolic process(GO:0006531)
0.1 0.1 GO:0009187 cyclic nucleotide metabolic process(GO:0009187)
0.1 0.4 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.1 0.3 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.1 0.6 GO:0090114 COPII-coated vesicle budding(GO:0090114)
0.1 0.5 GO:0006826 iron ion transport(GO:0006826)
0.1 0.3 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.2 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.0 0.2 GO:0034627 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.0 0.7 GO:1990778 protein localization to plasma membrane(GO:0072659) establishment of protein localization to plasma membrane(GO:0090002) protein localization to cell periphery(GO:1990778)
0.0 0.2 GO:0006078 (1->6)-beta-D-glucan biosynthetic process(GO:0006078)
0.0 0.1 GO:0019935 cAMP-mediated signaling(GO:0019933) cyclic-nucleotide-mediated signaling(GO:0019935)
0.0 0.1 GO:0090399 replicative senescence(GO:0090399)
0.0 0.4 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.0 0.2 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.0 0.4 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.3 GO:0000132 establishment of mitotic spindle orientation(GO:0000132) establishment of mitotic spindle localization(GO:0040001) establishment of spindle orientation(GO:0051294)
0.0 0.2 GO:0018202 peptidyl-histidine modification(GO:0018202)
0.0 0.0 GO:0030307 positive regulation of cell growth(GO:0030307) positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter(GO:1900461) positive regulation of pseudohyphal growth(GO:2000222)
0.0 0.5 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.0 0.2 GO:1901658 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.0 0.2 GO:0009395 phospholipid catabolic process(GO:0009395)
0.0 1.1 GO:0006631 fatty acid metabolic process(GO:0006631)
0.0 0.2 GO:0034085 establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087)
0.0 0.2 GO:0006452 translational frameshifting(GO:0006452)
0.0 0.3 GO:0001300 chronological cell aging(GO:0001300)
0.0 0.1 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.0 0.1 GO:0015793 glycerol transport(GO:0015793)
0.0 0.1 GO:0031930 mitochondria-nucleus signaling pathway(GO:0031930)
0.0 0.4 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.2 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.1 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.2 GO:1901264 carbohydrate derivative transport(GO:1901264)
0.0 0.0 GO:0032075 regulation of nuclease activity(GO:0032069) regulation of deoxyribonuclease activity(GO:0032070) regulation of endodeoxyribonuclease activity(GO:0032071) positive regulation of nuclease activity(GO:0032075) positive regulation of deoxyribonuclease activity(GO:0032077) positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.0 0.1 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.0 0.0 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 0.0 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491)
0.0 0.1 GO:0009435 NAD biosynthetic process(GO:0009435)
0.0 0.0 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.0 0.2 GO:0006200 obsolete ATP catabolic process(GO:0006200)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 9.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
1.6 7.9 GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
1.4 4.1 GO:0005756 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
1.1 3.4 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.9 4.5 GO:0072379 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.9 6.9 GO:0042597 periplasmic space(GO:0042597)
0.9 7.7 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.8 3.2 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.7 1.5 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.7 2.2 GO:0045240 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.7 1.4 GO:0030061 mitochondrial crista(GO:0030061)
0.7 6.3 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.6 8.0 GO:0070469 respiratory chain(GO:0070469)
0.6 4.0 GO:0034657 GID complex(GO:0034657)
0.6 2.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.5 6.0 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.5 9.6 GO:0031307 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.5 0.5 GO:0031931 TORC1 complex(GO:0031931)
0.5 3.0 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.5 1.5 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.5 3.7 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.5 5.1 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.5 1.4 GO:0001400 mating projection base(GO:0001400)
0.4 1.2 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.4 3.9 GO:0045259 mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259)
0.3 0.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.3 4.8 GO:0009277 fungal-type cell wall(GO:0009277)
0.3 1.6 GO:0008180 COP9 signalosome(GO:0008180)
0.2 1.0 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.2 3.0 GO:0005619 ascospore wall(GO:0005619)
0.2 17.7 GO:0005576 extracellular region(GO:0005576)
0.2 5.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.2 0.7 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.2 9.7 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.2 0.8 GO:0032116 SMC loading complex(GO:0032116)
0.2 1.4 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.2 3.3 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.2 1.3 GO:0033101 cellular bud membrane(GO:0033101)
0.2 26.5 GO:0000322 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.1 3.0 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 0.6 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 2.6 GO:0005811 lipid particle(GO:0005811)
0.1 0.5 GO:0005825 half bridge of spindle pole body(GO:0005825)
0.1 1.6 GO:0098552 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.1 0.6 GO:0032221 Rpd3S complex(GO:0032221)
0.1 0.6 GO:0005869 dynactin complex(GO:0005869)
0.1 0.2 GO:0097002 mitochondrial inner boundary membrane(GO:0097002)
0.1 2.6 GO:0005770 late endosome(GO:0005770)
0.1 0.9 GO:0000795 synaptonemal complex(GO:0000795)
0.1 74.8 GO:0005739 mitochondrion(GO:0005739)
0.1 0.5 GO:0032432 actin filament bundle(GO:0032432)
0.1 0.3 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 0.9 GO:0070822 Sin3-type complex(GO:0070822)
0.1 0.9 GO:0090544 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.1 0.5 GO:0000839 Hrd1p ubiquitin ligase complex(GO:0000836) Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.1 0.3 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.1 1.3 GO:0016592 mediator complex(GO:0016592)
0.1 0.9 GO:0031201 SNARE complex(GO:0031201)
0.1 0.2 GO:0000817 COMA complex(GO:0000817)
0.1 0.1 GO:0032126 eisosome(GO:0032126)
0.1 0.3 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.2 GO:0033551 monopolin complex(GO:0033551)
0.0 1.2 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.6 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.3 GO:0035267 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.2 GO:0070775 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.0 0.1 GO:0032389 MutLalpha complex(GO:0032389)
0.0 1.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.1 GO:0097196 Shu complex(GO:0097196)
0.0 0.3 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 14.9 GO:0004396 hexokinase activity(GO:0004396)
3.1 9.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
3.0 14.8 GO:0015295 solute:proton symporter activity(GO:0015295)
2.5 7.4 GO:0004866 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
2.1 8.3 GO:0004614 phosphoglucomutase activity(GO:0004614)
1.6 7.9 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
1.5 4.6 GO:0016289 CoA hydrolase activity(GO:0016289)
1.5 4.6 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
1.5 4.4 GO:0004564 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
1.3 5.3 GO:0005537 mannose binding(GO:0005537)
1.3 3.8 GO:0090599 alpha-glucosidase activity(GO:0090599)
1.2 6.0 GO:0050308 sugar-phosphatase activity(GO:0050308)
1.2 4.7 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
1.1 3.2 GO:0003954 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
1.1 3.2 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
1.1 3.2 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
1.0 6.1 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
1.0 4.1 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.9 2.8 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.9 15.8 GO:0046906 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.9 3.7 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.9 12.3 GO:0005353 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.8 3.2 GO:0042927 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.8 2.3 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.8 10.0 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.7 1.5 GO:0015151 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.7 5.1 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.7 1.4 GO:0051213 dioxygenase activity(GO:0051213)
0.7 5.3 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.7 7.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.6 1.3 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.6 4.2 GO:0004364 glutathione transferase activity(GO:0004364)
0.6 4.7 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.6 2.3 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.5 3.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.5 2.6 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.5 2.0 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.5 3.0 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.5 1.5 GO:0016872 intramolecular lyase activity(GO:0016872)
0.5 4.3 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.5 5.8 GO:0022838 substrate-specific channel activity(GO:0022838)
0.5 1.4 GO:0016406 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
0.5 2.3 GO:0008198 ferrous iron binding(GO:0008198)
0.5 5.4 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.4 1.3 GO:0033549 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.4 3.5 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.4 3.0 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.4 1.3 GO:0015175 L-tyrosine transmembrane transporter activity(GO:0005302) neutral amino acid transmembrane transporter activity(GO:0015175) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.4 1.7 GO:0004180 carboxypeptidase activity(GO:0004180)
0.4 1.2 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
0.4 3.2 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.4 4.2 GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism(GO:0015662)
0.4 5.1 GO:0004872 receptor activity(GO:0004872) molecular transducer activity(GO:0060089)
0.4 11.3 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.3 0.7 GO:0015085 calcium ion transmembrane transporter activity(GO:0015085)
0.3 3.4 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.3 0.3 GO:0016411 acylglycerol O-acyltransferase activity(GO:0016411)
0.3 24.8 GO:0051082 unfolded protein binding(GO:0051082)
0.3 0.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.3 1.3 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.3 1.7 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.3 1.7 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.3 0.9 GO:0070569 uridylyltransferase activity(GO:0070569)
0.3 0.9 GO:0016405 AMP binding(GO:0016208) CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
0.3 1.7 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
0.3 0.8 GO:0008902 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.3 1.4 GO:0042171 lysophosphatidic acid acyltransferase activity(GO:0042171)
0.3 1.3 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.3 0.8 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.2 2.2 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.2 2.5 GO:0001083 transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083)
0.2 1.3 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.2 2.4 GO:0015036 disulfide oxidoreductase activity(GO:0015036)
0.2 2.0 GO:0031386 protein tag(GO:0031386)
0.2 1.0 GO:0017022 myosin binding(GO:0017022)
0.2 0.6 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.2 0.6 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.2 1.6 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.2 0.9 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.2 0.4 GO:0045118 azole transporter activity(GO:0045118)
0.2 1.6 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.2 0.3 GO:0015294 solute:cation symporter activity(GO:0015294)
0.2 2.0 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.2 2.9 GO:0050661 NADP binding(GO:0050661)
0.2 1.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 2.5 GO:0015297 antiporter activity(GO:0015297)
0.1 0.7 GO:0008171 O-methyltransferase activity(GO:0008171)
0.1 0.7 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 0.7 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.1 0.3 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
0.1 2.5 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 2.5 GO:0016830 carbon-carbon lyase activity(GO:0016830)
0.1 0.6 GO:0070403 NAD+ binding(GO:0070403)
0.1 0.4 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.1 0.5 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen(GO:0016705)
0.1 0.2 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.1 0.2 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.1 0.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 1.3 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.1 0.6 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.1 2.2 GO:0004857 enzyme inhibitor activity(GO:0004857)
0.1 0.1 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.1 0.5 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.1 1.6 GO:0016769 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.1 0.4 GO:0004075 biotin carboxylase activity(GO:0004075)
0.1 0.9 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 0.2 GO:0070336 flap-structured DNA binding(GO:0070336)
0.1 0.9 GO:0045182 translation regulator activity(GO:0045182)
0.1 0.2 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.1 0.4 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.1 0.3 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.1 0.2 GO:0019776 Atg8 ligase activity(GO:0019776)
0.1 0.2 GO:0055103 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106) ubiquitin-protein transferase activator activity(GO:0097027)
0.1 3.3 GO:0001228 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 0.3 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 0.3 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.1 0.3 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.1 1.0 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.1 1.1 GO:0005509 calcium ion binding(GO:0005509)
0.1 0.1 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 1.1 GO:0016298 lipase activity(GO:0016298)
0.1 0.2 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 0.2 GO:0004457 lactate dehydrogenase activity(GO:0004457) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
0.0 0.2 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.0 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 1.1 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.3 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.4 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.0 0.1 GO:0008169 C-methyltransferase activity(GO:0008169)
0.0 0.4 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.0 0.6 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.0 0.3 GO:1901505 carbohydrate derivative transporter activity(GO:1901505)
0.0 0.1 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.0 0.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 1.0 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.1 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.4 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.9 GO:0050662 coenzyme binding(GO:0050662)
0.0 0.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.1 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.0 0.2 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 0.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.7 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.1 GO:0015293 symporter activity(GO:0015293)
0.0 1.6 GO:0016758 transferase activity, transferring hexosyl groups(GO:0016758)
0.0 0.1 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.0 1.5 GO:0019787 ubiquitin-like protein transferase activity(GO:0019787)
0.0 0.0 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0 0.1 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.0 0.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.1 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 0.0 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0 0.2 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.1 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0 0.1 GO:0010181 FMN binding(GO:0010181)
0.0 0.1 GO:0005507 copper ion binding(GO:0005507)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 9.0 PID IL4 2PATHWAY IL4-mediated signaling events
0.7 2.0 PID NOTCH PATHWAY Notch signaling pathway
0.5 1.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.4 2.0 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.4 1.1 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.3 1.0 PID FOXO PATHWAY FoxO family signaling
0.2 0.2 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 0.6 PID PLK1 PATHWAY PLK1 signaling events
0.1 0.4 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 0.1 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.0 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 0.0 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.0 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 0.2 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 43.8 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 16.7 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
1.0 3.1 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.6 1.7 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 0.4 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 0.1 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.1 0.7 REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.0 0.1 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.4 REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS Genes involved in Metabolism of lipids and lipoproteins
0.0 0.3 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.3 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 40.6 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.0 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling