Results for MIG2
Z-value: 0.78
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Transcription factors associated with MIG2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
MIG2
|
S000003177 | Zinc finger transcriptional repressor |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YDR342C Show fit | 12.14 |
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels |
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| YIL162W Show fit | 6.90 |
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively |
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| YGR067C Show fit | 6.83 |
Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p |
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| YGR243W Show fit | 6.72 |
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
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| YFR053C Show fit | 6.62 |
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p |
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| YDR343C Show fit | 6.32 |
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3 |
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| YNR073C Show fit | 5.79 |
Putative mannitol dehydrogenase |
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| YKL217W Show fit | 5.53 |
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose |
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| YLR327C Show fit | 5.35 |
Protein of unknown function that associates with ribosomes |
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| YDR536W Show fit | 4.98 |
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock |
Network of associatons between targets according to the STRING database.
First level regulatory network of MIG2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 13.5 | GO:0015749 | hexose transport(GO:0008645) monosaccharide transport(GO:0015749) |
| 3.1 | 12.2 | GO:0006848 | pyruvate transport(GO:0006848) |
| 1.1 | 9.7 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 0.9 | 7.3 | GO:0005987 | sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987) |
| 0.5 | 7.0 | GO:0005978 | glycogen biosynthetic process(GO:0005978) |
| 2.3 | 6.9 | GO:0015755 | fructose transport(GO:0015755) |
| 0.1 | 6.3 | GO:0009060 | aerobic respiration(GO:0009060) |
| 0.6 | 6.0 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 1.1 | 5.5 | GO:0019563 | alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563) |
| 0.2 | 5.4 | GO:0006094 | gluconeogenesis(GO:0006094) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 37.5 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 19.8 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.2 | 12.8 | GO:0005576 | extracellular region(GO:0005576) |
| 0.6 | 5.7 | GO:0045275 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.9 | 4.3 | GO:0045283 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
| 0.0 | 3.8 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.4 | 3.5 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.1 | 3.2 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.4 | 3.1 | GO:0034657 | GID complex(GO:0034657) |
| 0.2 | 3.1 | GO:0031306 | intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 11.6 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 1.9 | 7.4 | GO:0004396 | hexokinase activity(GO:0004396) |
| 2.4 | 7.3 | GO:0004575 | beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575) |
| 2.2 | 6.7 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
| 1.6 | 6.6 | GO:0015146 | pentose transmembrane transporter activity(GO:0015146) |
| 0.0 | 6.6 | GO:0016773 | phosphotransferase activity, alcohol group as acceptor(GO:0016773) |
| 0.7 | 5.4 | GO:0016679 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.3 | 5.3 | GO:0046906 | heme binding(GO:0020037) tetrapyrrole binding(GO:0046906) |
| 0.4 | 4.5 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 1.4 | 4.2 | GO:0090599 | alpha-glucosidase activity(GO:0090599) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.7 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.9 | 2.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.4 | 2.5 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.3 | 0.9 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 0.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 0.2 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.6 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.6 | 6.9 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |
| 0.3 | 2.3 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 0.3 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.1 | 0.3 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.0 | 0.3 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.1 | 0.1 | REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE | Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle |
| 0.0 | 0.1 | REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES | Genes involved in Transmembrane transport of small molecules |
| 0.0 | 0.1 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |