Results for MGA1
Z-value: 0.41
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Transcription factors associated with MGA1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
MGA1
|
S000003481 | Protein similar to heat shock transcription factor |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YFL051C Show fit | 2.19 |
Putative protein of unknown function; YFL051C is not an essential gene |
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| YBR117C Show fit | 2.01 |
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids |
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| YKL038W Show fit | 1.45 |
Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor |
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| YJL130C Show fit | 1.42 |
Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP |
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| YDR541C Show fit | 1.35 |
Putative dihydrokaempferol 4-reductase |
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| YAL054C Show fit | 1.29 |
Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions |
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| YDR542W Show fit | 1.26 |
Hypothetical protein |
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| YDR342C Show fit | 1.24 |
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels |
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| YHR092C Show fit | 1.20 |
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose |
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| YFR053C Show fit | 1.14 |
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p |
Network of associatons between targets according to the STRING database.
First level regulatory network of MGA1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 2.6 | GO:0046323 | glucose import(GO:0046323) |
| 0.3 | 2.6 | GO:0015891 | siderophore transport(GO:0015891) |
| 0.4 | 2.4 | GO:0000128 | flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501) |
| 0.2 | 2.3 | GO:0006098 | pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682) |
| 0.2 | 2.1 | GO:0046487 | glyoxylate metabolic process(GO:0046487) |
| 0.1 | 2.1 | GO:0042724 | thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724) |
| 0.1 | 2.0 | GO:0008645 | hexose transport(GO:0008645) monosaccharide transport(GO:0015749) |
| 0.2 | 1.9 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.3 | 1.8 | GO:0006207 | 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205) |
| 0.1 | 1.6 | GO:0006101 | tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.3 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 3.1 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 2.8 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 2.2 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.1 | 1.8 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.0 | 1.7 | GO:0005576 | extracellular region(GO:0005576) |
| 0.1 | 1.3 | GO:0045277 | mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277) |
| 0.1 | 1.2 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 1.2 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 1.2 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 2.5 | GO:0005537 | mannose binding(GO:0005537) |
| 0.1 | 2.2 | GO:0001191 | transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191) |
| 0.4 | 1.9 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 0.3 | 1.9 | GO:0016744 | transferase activity, transferring aldehyde or ketonic groups(GO:0016744) |
| 0.4 | 1.7 | GO:0015343 | siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927) |
| 0.5 | 1.5 | GO:0004088 | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088) |
| 0.1 | 1.4 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 0.4 | 1.3 | GO:0016880 | acid-ammonia (or amide) ligase activity(GO:0016880) |
| 0.3 | 1.3 | GO:0004396 | hexokinase activity(GO:0004396) |
| 0.1 | 1.3 | GO:0016675 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 21.9 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.3 | 0.8 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.2 | 0.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 0.5 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.3 | 0.3 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 0.2 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 0.1 | PID FOXO PATHWAY | FoxO family signaling |
| 0.0 | 0.1 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.0 | 0.1 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 0.1 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 21.8 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.4 | 1.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.3 | 0.9 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 0.9 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.2 | 0.5 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.0 | 0.5 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |
| 0.0 | 0.2 | REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM | Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism |
| 0.1 | 0.1 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.0 | 0.1 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.0 | 0.0 | REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT | Genes involved in The citric acid (TCA) cycle and respiratory electron transport |