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Results for MCM1

Z-value: 1.79

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Transcription factors associated with MCM1

Gene Symbol Gene ID Gene Info
MCM1
S000004646 Transcription factor involved in both repression and activation

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MCM1YMR043W-0.782.4e-06Click!

Activity profile of MCM1 motif

Sorted Z-values of MCM1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YFR055W 10.43
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YPR119W 9.55
CLB2
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YFR056C 9.26 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YGR279C 8.93
SCW4
Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating
YMR032W 8.86
HOF1
Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p
YHR092C 8.61
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YNL160W 8.51
YGP1
Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p
YDR133C 8.19 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YBR067C 7.58
TIP1
Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
YBR092C 7.55
PHO3
Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin
YIL158W 7.54
AIM20
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YEL040W 7.02
UTR2
Cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; putative chitin transglycosidase; glycosylphosphatidylinositol (GPI)-anchored protein localized to the bud neck; has a role in cell wall maintenance
YLR110C 6.71
CCW12
Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor
YOR315W 6.38
SFG1
Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
YPR157W 6.22 Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YNL327W 5.44
EGT2
Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner
YNR067C 5.27
DSE4
Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother
YAL038W 5.19
CDC19
Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration
YBR158W 5.17
AMN1
Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YJR094W-A 5.06
RPL43B
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YJL159W 4.84
HSP150
O-mannosylated heat shock protein that is secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation
YNL289W 4.74
PCL1
Pho85 cyclin of the Pcl1,2-like subfamily, involved in entry into the mitotic cell cycle and regulation of morphogenesis, localizes to sites of polarized cell growth
YKL096W-A 4.65
CWP2
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YML052W 4.61
SUR7
Putative integral membrane protein; component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
YDR044W 4.54
HEM13
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YFL026W 4.50
STE2
Receptor for alpha-factor pheromone; seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells
YKL164C 4.50
PIR1
O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle
YMR251W-A 4.48
HOR7
Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor
YJL196C 4.21
ELO1
Elongase I, medium-chain acyl elongase, catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids
YOL154W 4.21
ZPS1
Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
YDR033W 4.11
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YPL256C 3.84
CLN2
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YOR314W 3.79 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHL028W 3.62
WSC4
ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3
YMR122W-A 3.33 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and endoplasmic reticulum
YGR108W 3.33
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YPR113W 3.29
PIS1
Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins
YMR305C 3.27
SCW10
Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p
YGR086C 3.22
PIL1
Primary component of eisosomes, which are large immobile cell cortex structures associated with endocytosis; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria
YDR345C 3.07
HXT3
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YJL079C 2.96
PRY1
Protein of unknown function, has similarity to Pry2p and Pry3p and to the plant PR-1 class of pathogen related proteins
YNR001W-A 2.89 Dubious open reading frame unlikely to encode a functional protein; identified by homology
YIR021W 2.87
MRS1
Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YML132W 2.80
COS3
Protein involved in salt resistance; interacts with sodium:hydrogen antiporter Nha1p; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YOL155C 2.74
HPF1
Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines
YNL336W 2.68
COS1
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YDL236W 2.68
PHO13
Alkaline phosphatase specific for p-nitrophenyl phosphate, involved in dephosphorylation of histone II-A and casein
YKL185W 2.66
ASH1
Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate
YNL300W 2.62 Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid
YJL157C 2.58
FAR1
Cyclin-dependent kinase inhibitor that mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate
YIL123W 2.51
SIM1
Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
YKL152C 2.49
GPM1
Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
YER131W 2.46
RPS26B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YIL015W 2.39
BAR1
Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest
YER070W 2.38
RNR1
One of two large regulatory subunits of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits
YKR013W 2.35
PRY2
Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins
YBR053C 2.34 Putative protein of unknown function; induced by cell wall perturbation
YOR247W 2.33
SRL1
Mannoprotein that exhibits a tight association with the cell wall, required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants
YIL114C 2.30
POR2
Putative mitochondrial porin (voltage-dependent anion channel), related to Por1p but not required for mitochondrial membrane permeability or mitochondrial osmotic stability
YNL338W 2.24 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV
YPL014W 2.14 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
YKL209C 2.10
STE6
Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells
YMR001C-A 2.09 Putative protein of unknown function
YPR149W 2.09
NCE102
Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs)
YBR009C 2.09
HHF1
One of two identical histone H4 proteins (see also HHF2); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
YCR102W-A 2.07 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOL130W 2.05
ALR1
Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions
YFR054C 2.02 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR141C 1.87
RPL42B
Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to rat L44; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus
YEL034C-A 1.85 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; completely overlaps HYP2/YEL034W, a verified gene that encodes eiF-5A
YKR012C 1.84 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2
YLR113W 1.79
HOG1
Mitogen-activated protein kinase involved in osmoregulation via three independent osmosensors; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p
YKL216W 1.77
URA1
Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid
YLR190W 1.74
MMR1
Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p
YOR313C 1.74
SPS4
Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage
YLR028C 1.73
ADE16
Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade17p; ade16 ade17 mutants require adenine and histidine
YPR069C 1.70
SPE3
Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells
YFL027C 1.65
GYP8
GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport
YKL080W 1.64
VMA5
Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
YHR149C 1.64
SKG6
Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
YBR093C 1.62
PHO5
Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
YJL158C 1.62
CIS3
Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
YNL066W 1.60
SUN4
Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family
YPR148C 1.60 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YEL066W 1.59
HPA3
D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro
YOR103C 1.59
OST2
Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
YMR122C 1.58 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR007C 1.54
ERG11
Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family
YAL040C 1.53
CLN3
G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis
YDR465C 1.53
RMT2
Arginine methyltransferase; ribosomal protein L12 is a substrate
YIL009C-A 1.52
EST3
Component of the telomerase holoenzyme, involved in telomere replication
YKR092C 1.51
SRP40
Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YOR226C 1.51
ISU2
Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable
YIR020C 1.51 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR014W 1.49
MSB2
Mucin family member involved in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate
YGL256W 1.49
ADH4
Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency
YDR309C 1.48
GIC2
Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
YCL049C 1.48 Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene;
YGR078C 1.48
PAC10
Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding
YPR156C 1.46
TPO3
Polyamine transport protein specific for spermine; localizes to the plasma membrane; member of the major facilitator superfamily
YKR038C 1.44
KAE1
Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex
YHR005C-A 1.44
MRS11
Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that mediates insertion of hydrophobic proteins at the inner membrane, has homology to Mrs5p, which is also involved in this process
YLR432W 1.44
IMD3
Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
YIL009W 1.43
FAA3
Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YCL048W-A 1.43 Putative protein of unknown function
YLR112W 1.40 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR451C 1.39
YHP1
One of two homeobox transcriptional repressors (see also Yox1p), that bind to Mcm1p and to early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval
YMR121C 1.38
RPL15B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Ap and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA
YIR013C 1.34
GAT4
Protein containing GATA family zinc finger motifs
YIR020W-A 1.33 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YJR145C 1.33
RPS4A
Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein
YHR005C 1.32
GPA1
GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates Vps34p at the endosome
YFR015C 1.32
GSY1
Glycogen synthase with similarity to Gsy2p, the more highly expressed yeast homolog; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase
YMR199W 1.32
CLN1
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YIL169C 1.31 Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene
YJL145W 1.29
SFH5
Putative phosphatidylinositol transfer protein (PITP), exhibits phosphatidylinositol- but not phosphatidylcholine-transfer activity, localized to cytosol and microsomes, similar to Sec14p; may be PITP regulator rather than actual PITP
YNL058C 1.29 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene
YMR266W 1.29
RSN1
Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant
YNL078W 1.29
NIS1
Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network
YOR273C 1.29
TPO4
Polyamine transport protein, recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily
YDR032C 1.28
PST2
Protein with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YHR094C 1.25
HXT1
Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YLR196W 1.24
PWP1
Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily
YNL301C 1.23
RPL18B
Protein component of the large (60S) ribosomal subunit, identical to Rpl18Ap and has similarity to rat L18 ribosomal protein
YLR257W 1.22 Putative protein of unknown function
YLR120C 1.21
YPS1
Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YNL079C 1.19
TPM1
Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently
YBR010W 1.18
HHT1
One of two identical histone H3 proteins (see also HHT2); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation
YCL050C 1.18
APA1
Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase I (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa2p
YLL064C 1.18
PAU18
Hypothetical protein
YGL032C 1.17
AGA2
Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds
YDR399W 1.15
HPT1
Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome
YGL257C 1.13
MNT2
Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans
YML119W 1.11 Putative protein of unknown funtion; YML119W is not an essential gene; potential Cdc28p substrate
YBR164C 1.11
ARL1
Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor
YOL007C 1.10
CSI2
Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene
YER091C 1.10
MET6
Cobalamin-independent methionine synthase, involved in amino acid biosynthesis; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs
YDR276C 1.10
PMP3
Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential
YAL022C 1.09
FUN26
Nucleoside transporter with broad nucleoside selectivity; localized to intracellular membranes
YCR104W 1.08
PAU3
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YGL039W 1.07 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YBR054W 1.06
YRO2
Putative protein of unknown function; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p
YLR154C 1.04
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YOL127W 1.03
RPL25
Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 26S rRNA via a conserved C-terminal motif
YNL057W 1.03 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL165C 1.03
MCD4
Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes
YGL201C 1.03
MCM6
Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YGR164W 1.02 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL178W 1.01
RPS3
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YER031C 1.01
YPT31
GTPase of the Ypt/Rab family, very similar to Ypt32p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi
YNL337W 1.00 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YML058W 1.00
SML1
Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase
YGL040C 0.99
HEM2
Delta-aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen, the second step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus
YFR005C 0.99
SAD1
Conserved zinc-finger domain protein involved in pre-mRNA splicing, required for assembly of U4 snRNA into the U4/U6 particle
YGL258W 0.97
VEL1
Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants
YPR063C 0.97 ER-localized protein of unknown function
YBL092W 0.96
RPL32
Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing
YGL088W 0.95 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing
YOR222W 0.95
ODC2
Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism
YGL021W 0.95
ALK1
Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk2p and to mammalian haspins
YDL037C 0.94
BSC1
Protein of unconfirmed function, similar to cell surface flocculin Muc1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
YCR018C 0.93
SRD1
Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YER130C 0.93 Hypothetical protein
YEL068C 0.93 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YAR020C 0.93
PAU7
Part of 23-member seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme
YLR341W 0.92
SPO77
Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis
YDR341C 0.92 Arginyl-tRNA synthetase, proposed to be cytoplasmic but the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YFL062W 0.92
COS4
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YJL170C 0.92
ASG7
Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factor
YHL018W 0.91 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria and is induced in response to the DNA-damaging agent MMS
YMR009W 0.91
ADI1
Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions
YAR071W 0.89
PHO11
One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
YPR196W 0.89 Putative maltose activator
YFL015W-A 0.88 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR214W 0.88
RPS0A
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YLR183C 0.87
TOS4
Transcription factor that binds to a number of promoter regions, particularly promoters of some genes involved in pheromone response and cell cycle; potential Cdc28p substrate; expression is induced in G1 by bound SBF
YLR154W-B 0.86 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YGR284C 0.86
ERV29
Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo
YGR189C 0.85
CRH1
Putative chitin transglycosidase, cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; localizes to sites of polarized growth; expression is induced under cell wall stress conditions
YPL274W 0.85
SAM3
High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p
YIL069C 0.85
RPS24B
Protein component of the small (40S) ribosomal subunit; identical to Rps24Ap and has similarity to rat S24 ribosomal protein
YIL076W 0.84
SEC28
Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth
YDR225W 0.84
HTA1
One of two nearly identical (see also HTA2) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
YIL118W 0.84
RHO3
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YPL079W 0.83
RPL21B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Ap and has similarity to rat L21 ribosomal protein
YGR169C-A 0.83 Putative protein of unknown function
YMR006C 0.82
PLB2
Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine
YHR144C 0.82
DCD1
Deoxycytidine monophosphate (dCMP) deaminase required for dCTP and dTTP synthesis; expression is NOT cell cycle regulated
YCR102C 0.82 Putative protein of unknown function; involved in copper metabolism; similar to C.carbonum toxD gene; YCR102C is not an essential gene
YEL017W 0.82
GTT3
Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery
YHR013C 0.80
ARD1
Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
YJR099W 0.80
YUH1
Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p
YGR177C 0.80
ATF2
Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important in brewing
YKR093W 0.80
PTR2
Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
YGR106C 0.79
VOA1
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane
YOR011W 0.79
AUS1
Transporter of the ATP-binding cassette family, involved in uptake of sterols and anaerobic growth
YCR024C-B 0.78 Putative protein of unknown function; identified by expression profiling and mass spectrometry
YGL202W 0.78
ARO8
Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis
YFL015C 0.78 Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
YGR107W 0.78 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Network of associatons between targets according to the STRING database.

First level regulatory network of MCM1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 10.4 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
1.8 5.3 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
1.7 11.8 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
1.7 6.6 GO:0098742 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
1.2 5.9 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
1.1 4.2 GO:0030497 fatty acid elongation(GO:0030497)
0.9 11.2 GO:0090529 barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529)
0.9 2.8 GO:0006883 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.9 2.7 GO:0045596 negative regulation of cell differentiation(GO:0045596)
0.9 2.6 GO:0071850 mitotic cell cycle arrest in response to pheromone(GO:0000751) mitotic cell cycle arrest(GO:0071850)
0.8 5.5 GO:0046501 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.8 3.1 GO:0000296 spermine transport(GO:0000296)
0.8 4.5 GO:0051260 protein homooligomerization(GO:0051260)
0.7 2.1 GO:0015693 magnesium ion transport(GO:0015693)
0.7 2.7 GO:0046898 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
0.6 3.6 GO:0070941 eisosome assembly(GO:0070941)
0.6 2.4 GO:0044070 regulation of anion transport(GO:0044070)
0.6 8.9 GO:0006037 cell wall chitin metabolic process(GO:0006037)
0.6 1.7 GO:0008216 spermidine metabolic process(GO:0008216)
0.5 1.6 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.5 2.6 GO:0006177 GMP biosynthetic process(GO:0006177)
0.5 1.5 GO:1902223 L-phenylalanine biosynthetic process(GO:0009094) erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process(GO:1902223)
0.5 1.5 GO:0018195 peptidyl-arginine modification(GO:0018195) peptidyl-arginine methylation(GO:0018216)
0.5 1.5 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
0.4 0.8 GO:0015848 spermidine transport(GO:0015848)
0.4 5.7 GO:0007009 plasma membrane organization(GO:0007009)
0.4 1.6 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.4 2.0 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.4 0.4 GO:0051439 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.4 1.1 GO:0009177 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) deoxyribonucleoside monophosphate metabolic process(GO:0009162) pyrimidine deoxyribonucleoside monophosphate metabolic process(GO:0009176) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177)
0.4 2.9 GO:0000372 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.3 5.2 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.3 2.4 GO:0043171 peptide catabolic process(GO:0043171)
0.3 1.6 GO:0060277 obsolete negative regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0060277)
0.3 7.7 GO:0008645 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.3 5.5 GO:0051029 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
0.3 0.9 GO:0071169 establishment of protein localization to chromosome(GO:0070199) establishment of protein localization to chromatin(GO:0071169)
0.3 5.6 GO:0042723 thiamine-containing compound metabolic process(GO:0042723)
0.3 0.9 GO:0090110 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.3 1.4 GO:0007232 osmosensory signaling pathway via Sho1 osmosensor(GO:0007232)
0.3 6.9 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.3 4.0 GO:0015833 peptide transport(GO:0015833)
0.3 1.8 GO:0034729 histone H3-K79 methylation(GO:0034729)
0.3 1.0 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.3 1.0 GO:0015867 ATP transport(GO:0015867)
0.3 6.5 GO:0006885 regulation of pH(GO:0006885)
0.2 0.7 GO:0016094 polyprenol metabolic process(GO:0016093) polyprenol biosynthetic process(GO:0016094) dolichol metabolic process(GO:0019348) dolichol biosynthetic process(GO:0019408)
0.2 5.8 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.2 1.4 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.2 0.5 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.2 0.7 GO:0046466 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.2 3.8 GO:0032508 DNA duplex unwinding(GO:0032508)
0.2 1.9 GO:0009395 phospholipid catabolic process(GO:0009395)
0.2 0.8 GO:0051046 regulation of exocytosis(GO:0017157) regulation of secretion(GO:0051046) regulation of formin-nucleated actin cable assembly(GO:0090337) positive regulation of formin-nucleated actin cable assembly(GO:0090338) regulation of secretion by cell(GO:1903530)
0.2 0.6 GO:0043484 regulation of RNA splicing(GO:0043484) regulation of mRNA splicing, via spliceosome(GO:0048024)
0.2 0.6 GO:0007535 donor selection(GO:0007535)
0.2 1.6 GO:0006828 manganese ion transport(GO:0006828)
0.2 0.6 GO:1901073 aminoglycan biosynthetic process(GO:0006023) chitin biosynthetic process(GO:0006031) glucosamine-containing compound biosynthetic process(GO:1901073)
0.2 1.7 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.2 0.9 GO:0032261 purine nucleotide salvage(GO:0032261)
0.2 0.9 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.2 0.9 GO:0006491 N-glycan processing(GO:0006491)
0.2 0.5 GO:0006505 GPI anchor metabolic process(GO:0006505)
0.2 0.7 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
0.2 1.7 GO:0007021 tubulin complex assembly(GO:0007021)
0.2 2.2 GO:0006113 fermentation(GO:0006113)
0.2 1.0 GO:0009164 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.2 0.8 GO:0010992 ubiquitin homeostasis(GO:0010992)
0.2 1.1 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.1 1.2 GO:0061572 actin filament bundle assembly(GO:0051017) actin filament bundle organization(GO:0061572)
0.1 3.1 GO:0015918 sterol transport(GO:0015918)
0.1 0.7 GO:0070813 hydrogen sulfide metabolic process(GO:0070813) hydrogen sulfide biosynthetic process(GO:0070814)
0.1 2.0 GO:0007231 osmosensory signaling pathway(GO:0007231)
0.1 0.7 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.1 0.7 GO:0000390 spliceosomal complex disassembly(GO:0000390)
0.1 0.4 GO:0009090 homoserine biosynthetic process(GO:0009090)
0.1 1.3 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.1 17.9 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 1.2 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.1 4.0 GO:0045047 protein targeting to ER(GO:0045047)
0.1 3.1 GO:0006696 ergosterol biosynthetic process(GO:0006696) phytosteroid biosynthetic process(GO:0016129) cellular alcohol biosynthetic process(GO:0044108) cellular lipid biosynthetic process(GO:0097384)
0.1 0.2 GO:0019673 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
0.1 0.5 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
0.1 1.2 GO:0052803 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.1 0.5 GO:0046417 chorismate metabolic process(GO:0046417)
0.1 0.3 GO:0042992 regulation of transcription factor import into nucleus(GO:0042990) negative regulation of transcription factor import into nucleus(GO:0042992)
0.1 1.2 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.1 0.3 GO:0006531 aspartate metabolic process(GO:0006531)
0.1 1.1 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.1 0.7 GO:0018342 protein prenylation(GO:0018342) prenylation(GO:0097354)
0.1 1.0 GO:0006817 phosphate ion transport(GO:0006817)
0.1 0.4 GO:0010674 negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010674)
0.1 0.4 GO:0015883 FAD transport(GO:0015883)
0.1 0.7 GO:0009262 deoxyribonucleotide metabolic process(GO:0009262) deoxyribonucleotide biosynthetic process(GO:0009263)
0.1 2.8 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.1 1.5 GO:0008202 steroid metabolic process(GO:0008202) sterol metabolic process(GO:0016125)
0.1 0.5 GO:0051781 positive regulation of cell division(GO:0051781)
0.1 0.3 GO:0000092 mitotic anaphase B(GO:0000092)
0.1 3.7 GO:0070726 cell wall assembly(GO:0070726)
0.1 0.4 GO:0034227 tRNA wobble position uridine thiolation(GO:0002143) tRNA thio-modification(GO:0034227)
0.1 0.6 GO:0046931 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.1 2.1 GO:0048311 mitochondrion inheritance(GO:0000001) mitochondrion distribution(GO:0048311)
0.1 1.2 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.1 0.2 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.1 0.3 GO:0015809 arginine transport(GO:0015809)
0.1 0.3 GO:0005980 glycogen catabolic process(GO:0005980)
0.1 3.0 GO:0006661 phosphatidylinositol biosynthetic process(GO:0006661)
0.1 4.3 GO:0048468 ascospore formation(GO:0030437) cell development(GO:0048468)
0.1 0.3 GO:0010458 exit from mitosis(GO:0010458)
0.1 0.6 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.1 0.8 GO:0006826 iron ion transport(GO:0006826)
0.1 0.7 GO:0006901 vesicle coating(GO:0006901)
0.1 0.4 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.1 0.7 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362)
0.1 1.5 GO:0002098 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.1 0.7 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.1 0.3 GO:0033241 regulation of cellular amine catabolic process(GO:0033241)
0.1 0.3 GO:0006657 CDP-choline pathway(GO:0006657)
0.1 0.6 GO:0015858 nucleoside transport(GO:0015858)
0.1 0.2 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.1 0.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 0.3 GO:0045010 positive regulation of actin filament polymerization(GO:0030838) actin nucleation(GO:0045010)
0.1 0.3 GO:0006551 leucine metabolic process(GO:0006551) leucine biosynthetic process(GO:0009098)
0.1 1.1 GO:0098876 Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.1 0.3 GO:0060304 regulation of phosphatidylinositol dephosphorylation(GO:0060304) endoplasmic reticulum membrane organization(GO:0090158)
0.1 0.3 GO:0070096 mitochondrial outer membrane translocase complex assembly(GO:0070096)
0.1 0.4 GO:0000743 nuclear migration involved in conjugation with cellular fusion(GO:0000743)
0.1 0.2 GO:0006517 protein deglycosylation(GO:0006517)
0.1 0.7 GO:0009086 methionine biosynthetic process(GO:0009086)
0.1 0.2 GO:0046495 nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637)
0.1 0.4 GO:0009272 fungal-type cell wall biogenesis(GO:0009272)
0.1 0.2 GO:0000709 meiotic joint molecule formation(GO:0000709)
0.0 0.2 GO:0007329 positive regulation of transcription from RNA polymerase II promoter by pheromones(GO:0007329) positive regulation of transcription by pheromones(GO:0009371)
0.0 0.1 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.0 0.2 GO:0048279 vesicle fusion with endoplasmic reticulum(GO:0048279)
0.0 0.8 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.0 0.1 GO:0040031 snRNA pseudouridine synthesis(GO:0031120) snRNA modification(GO:0040031)
0.0 0.2 GO:0030011 maintenance of cell polarity(GO:0030011)
0.0 0.4 GO:0071039 nuclear polyadenylation-dependent CUT catabolic process(GO:0071039)
0.0 0.1 GO:0042822 pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823) aldehyde biosynthetic process(GO:0046184)
0.0 0.5 GO:0042181 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) ketone biosynthetic process(GO:0042181) quinone metabolic process(GO:1901661) quinone biosynthetic process(GO:1901663)
0.0 0.3 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
0.0 0.1 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.9 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.9 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.3 GO:0006591 ornithine metabolic process(GO:0006591)
0.0 0.3 GO:0006458 'de novo' protein folding(GO:0006458)
0.0 0.9 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.1 GO:0032006 regulation of TOR signaling(GO:0032006)
0.0 0.3 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 0.2 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.0 0.3 GO:0009636 response to toxic substance(GO:0009636)
0.0 0.1 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.0 0.1 GO:0015780 nucleotide-sugar transport(GO:0015780)
0.0 0.1 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.0 0.4 GO:0006098 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.0 0.1 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.3 GO:0043487 regulation of RNA stability(GO:0043487) regulation of mRNA stability(GO:0043488)
0.0 0.5 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.0 0.1 GO:0006621 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.0 0.1 GO:0046219 tryptophan biosynthetic process(GO:0000162) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
0.0 1.2 GO:0000910 cytokinesis(GO:0000910)
0.0 0.1 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.0 0.7 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.0 0.2 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity(GO:0051090)
0.0 0.1 GO:0015677 copper ion import(GO:0015677)
0.0 0.5 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.0 0.3 GO:0033967 box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963)
0.0 0.7 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 0.1 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.3 GO:0006415 translational termination(GO:0006415)
0.0 0.2 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.2 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.0 0.1 GO:0007008 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.2 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.0 0.1 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 1.1 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.1 GO:0015940 pantothenate metabolic process(GO:0015939) pantothenate biosynthetic process(GO:0015940)
0.0 0.2 GO:0015698 inorganic anion transport(GO:0015698)
0.0 0.1 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.0 0.1 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.0 0.2 GO:0006612 protein targeting to membrane(GO:0006612)
0.0 0.0 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 0.2 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.6 GO:0006413 translational initiation(GO:0006413)
0.0 0.6 GO:0016311 dephosphorylation(GO:0016311)
0.0 0.0 GO:0035753 maintenance of DNA trinucleotide repeats(GO:0035753)
0.0 0.4 GO:0006400 tRNA modification(GO:0006400)
0.0 0.1 GO:0070682 proteasome regulatory particle assembly(GO:0070682)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 10.7 GO:0030428 cell septum(GO:0030428)
2.2 8.9 GO:0044697 HICS complex(GO:0044697)
2.2 8.8 GO:0030287 cell wall-bounded periplasmic space(GO:0030287)
1.3 7.7 GO:0032126 eisosome(GO:0032126)
0.9 7.2 GO:0000144 cellular bud neck septin ring(GO:0000144)
0.8 2.4 GO:0046930 pore complex(GO:0046930)
0.6 10.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.5 33.8 GO:0005576 extracellular region(GO:0005576)
0.4 4.4 GO:0000788 nuclear nucleosome(GO:0000788)
0.4 1.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.3 1.0 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.3 1.5 GO:0030478 actin cap(GO:0030478)
0.3 1.4 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.3 2.2 GO:0033101 cellular bud membrane(GO:0033101)
0.3 1.9 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.3 0.8 GO:0031415 NatA complex(GO:0031415)
0.3 1.6 GO:0042555 MCM complex(GO:0042555)
0.3 1.8 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.2 6.5 GO:0009277 fungal-type cell wall(GO:0009277)
0.2 1.7 GO:0016272 prefoldin complex(GO:0016272)
0.2 6.0 GO:0005887 integral component of plasma membrane(GO:0005887)
0.2 17.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 1.6 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.2 0.8 GO:0042597 periplasmic space(GO:0042597)
0.2 0.7 GO:0070209 ASTRA complex(GO:0070209)
0.2 0.7 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.2 0.5 GO:0032807 DNA ligase IV complex(GO:0032807)
0.2 1.2 GO:0032432 actin filament bundle(GO:0032432)
0.2 2.9 GO:0070210 Rpd3L-Expanded complex(GO:0070210)
0.2 9.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.7 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.1 0.5 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.1 0.7 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 1.0 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 0.5 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 0.6 GO:0005940 septin ring(GO:0005940)
0.1 2.0 GO:0071782 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.1 0.8 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 8.7 GO:0005815 microtubule organizing center(GO:0005815) spindle pole body(GO:0005816)
0.1 0.6 GO:0034518 RNA cap binding complex(GO:0034518)
0.1 0.9 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 0.3 GO:0005871 kinesin complex(GO:0005871)
0.1 0.4 GO:0000938 GARP complex(GO:0000938)
0.1 3.6 GO:0000131 incipient cellular bud site(GO:0000131)
0.1 0.7 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.1 1.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 0.3 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.1 13.5 GO:0000324 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.1 0.3 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 0.6 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 0.3 GO:0033597 mitotic checkpoint complex(GO:0033597)
0.1 0.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 1.2 GO:0005811 lipid particle(GO:0005811)
0.1 2.4 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 0.1 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.1 0.2 GO:0071261 Ssh1 translocon complex(GO:0071261)
0.1 0.2 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 0.1 GO:0000229 cytoplasmic chromosome(GO:0000229) mitochondrial chromosome(GO:0000262)
0.0 0.1 GO:0030125 clathrin vesicle coat(GO:0030125)
0.0 0.7 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 15.2 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 0.1 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.0 0.2 GO:0030907 MBF transcription complex(GO:0030907)
0.0 0.2 GO:0048500 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0 0.1 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.3 GO:0000346 transcription export complex(GO:0000346)
0.0 0.1 GO:0032116 SMC loading complex(GO:0032116)
0.0 0.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 8.3 GO:0005886 plasma membrane(GO:0005886)
0.0 0.0 GO:0034456 UTP-C complex(GO:0034456)
0.0 2.1 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.5 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.2 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.1 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.8 GO:0032040 small-subunit processome(GO:0032040)
0.0 0.1 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.1 GO:0031933 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.0 0.1 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.1 GO:0034967 Set3 complex(GO:0034967)
0.0 0.1 GO:0035327 Cdc73/Paf1 complex(GO:0016593) transcriptionally active chromatin(GO:0035327)
0.0 0.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.5 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.1 GO:0098799 outer mitochondrial membrane protein complex(GO:0098799)
0.0 0.1 GO:0000922 spindle pole(GO:0000922)
0.0 0.4 GO:0044445 cytosolic part(GO:0044445)
0.0 0.1 GO:0030915 Smc5-Smc6 complex(GO:0030915)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 9.6 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
1.7 10.1 GO:0003993 acid phosphatase activity(GO:0003993)
1.6 6.3 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
1.5 4.4 GO:0004930 G-protein coupled receptor activity(GO:0004930)
1.4 8.5 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
1.4 4.2 GO:0009922 fatty acid elongase activity(GO:0009922)
1.3 5.3 GO:0042973 glucan endo-1,3-beta-D-glucosidase activity(GO:0042973)
1.0 17.8 GO:0015926 glucosidase activity(GO:0015926)
1.0 24.8 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.9 2.6 GO:0005253 anion channel activity(GO:0005253) voltage-gated anion channel activity(GO:0008308)
0.8 2.5 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
0.8 0.8 GO:0015248 sterol transporter activity(GO:0015248)
0.8 3.1 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
0.7 3.6 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.7 13.0 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.7 4.9 GO:0005216 ion channel activity(GO:0005216)
0.7 2.1 GO:0015440 peptide-transporting ATPase activity(GO:0015440)
0.6 7.6 GO:0005199 structural constituent of cell wall(GO:0005199)
0.5 5.3 GO:0005496 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.5 1.5 GO:0016274 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.5 2.0 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.5 1.4 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.5 1.9 GO:0004622 lysophospholipase activity(GO:0004622)
0.5 3.7 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.5 1.4 GO:0004100 chitin synthase activity(GO:0004100)
0.4 0.8 GO:0015606 spermidine transmembrane transporter activity(GO:0015606)
0.4 1.3 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.4 2.0 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.4 1.5 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.4 1.5 GO:0005034 osmosensor activity(GO:0005034)
0.4 1.8 GO:0004707 MAP kinase activity(GO:0004707)
0.3 1.3 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.3 1.6 GO:0070546 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.3 1.5 GO:0032451 demethylase activity(GO:0032451)
0.3 1.2 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.3 1.4 GO:0008525 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.3 1.4 GO:0017048 Rho GTPase binding(GO:0017048)
0.3 1.1 GO:0008172 S-methyltransferase activity(GO:0008172)
0.3 1.6 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.3 1.0 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.2 1.7 GO:0019238 hydroxymethyl-, formyl- and related transferase activity(GO:0016742) cyclohydrolase activity(GO:0019238)
0.2 0.7 GO:1901474 azole transmembrane transporter activity(GO:1901474)
0.2 1.5 GO:0051213 dioxygenase activity(GO:0051213)
0.2 0.6 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.2 0.6 GO:0072341 modified amino acid binding(GO:0072341)
0.2 0.8 GO:0009378 four-way junction helicase activity(GO:0009378)
0.2 1.6 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.2 0.6 GO:0000339 RNA cap binding(GO:0000339)
0.2 0.5 GO:0070568 guanylyltransferase activity(GO:0070568)
0.2 0.5 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.2 0.7 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.2 0.7 GO:0055106 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.2 1.4 GO:0031490 chromatin DNA binding(GO:0031490)
0.2 1.6 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.2 0.5 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.2 0.6 GO:0004771 sterol esterase activity(GO:0004771)
0.1 0.7 GO:0004026 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.1 4.6 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 1.3 GO:0010181 FMN binding(GO:0010181)
0.1 0.7 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.1 0.5 GO:0019206 nucleoside kinase activity(GO:0019206)
0.1 0.7 GO:0043139 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.1 4.2 GO:0008237 metallopeptidase activity(GO:0008237)
0.1 3.2 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.1 10.6 GO:0008092 cytoskeletal protein binding(GO:0008092)
0.1 0.6 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 24.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 0.8 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.1 0.5 GO:0016854 racemase and epimerase activity(GO:0016854)
0.1 0.7 GO:0008318 protein prenyltransferase activity(GO:0008318)
0.1 0.4 GO:0015085 calcium ion transmembrane transporter activity(GO:0015085) potassium:proton antiporter activity(GO:0015386) potassium ion antiporter activity(GO:0022821)
0.1 1.9 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.1 0.4 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.1 0.3 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 2.0 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 0.4 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 0.6 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.1 0.9 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.1 1.0 GO:0019239 deaminase activity(GO:0019239)
0.1 0.5 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.1 2.2 GO:0016836 hydro-lyase activity(GO:0016836)
0.1 0.3 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.1 0.8 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.1 1.2 GO:0001054 RNA polymerase I activity(GO:0001054)
0.1 0.3 GO:0019901 protein kinase binding(GO:0019901)
0.1 0.5 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.1 1.4 GO:0016866 intramolecular transferase activity(GO:0016866)
0.1 0.2 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.1 1.3 GO:0004221 obsolete ubiquitin thiolesterase activity(GO:0004221)
0.1 0.3 GO:0016408 C-acyltransferase activity(GO:0016408)
0.1 0.3 GO:0016840 carbon-nitrogen lyase activity(GO:0016840)
0.1 0.2 GO:0008169 C-methyltransferase activity(GO:0008169)
0.1 0.7 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.3 GO:0031386 protein tag(GO:0031386)
0.0 0.3 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.1 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 0.2 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.3 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.1 GO:0016882 cyclo-ligase activity(GO:0016882)
0.0 2.2 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.1 GO:0001055 RNA polymerase II activity(GO:0001055)
0.0 0.7 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.0 0.1 GO:0031370 eukaryotic initiation factor 4G binding(GO:0031370)
0.0 0.6 GO:0000049 tRNA binding(GO:0000049)
0.0 0.2 GO:0008312 7S RNA binding(GO:0008312)
0.0 1.3 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.2 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.2 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.3 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.3 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0 0.1 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.2 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.1 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.0 0.1 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670) oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671) thiol oxidase activity(GO:0016972)
0.0 0.6 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.7 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.3 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.0 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 0.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.8 GO:0016410 N-acyltransferase activity(GO:0016410)
0.0 0.1 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 0.1 GO:0001132 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132)
0.0 0.5 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 0.2 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.2 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.2 GO:0030295 protein kinase activator activity(GO:0030295)
0.0 0.1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.2 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.1 GO:0008144 drug binding(GO:0008144)
0.0 0.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.0 GO:0035591 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.0 0.2 GO:0005048 signal sequence binding(GO:0005048)
0.0 0.3 GO:0003743 translation initiation factor activity(GO:0003743)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 PID AR PATHWAY Coregulation of Androgen receptor activity
0.3 0.8 PID CDC42 PATHWAY CDC42 signaling events
0.2 0.4 PID E2F PATHWAY E2F transcription factor network
0.1 0.4 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 0.3 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.1 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.4 1.1 REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE Genes involved in NFkB and MAP kinases activation mediated by TLR4 signaling repertoire
0.3 2.4 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.3 0.9 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.3 0.9 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.2 1.6 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.2 3.2 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.2 0.4 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.1 0.3 REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.1 2.6 REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS Genes involved in Metabolism of lipids and lipoproteins
0.1 0.4 REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.1 0.5 REACTOME APOPTOSIS Genes involved in Apoptosis
0.1 0.4 REACTOME INTERFERON SIGNALING Genes involved in Interferon Signaling
0.1 0.2 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.3 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.5 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.2 REACTOME TRANSLATION Genes involved in Translation
0.0 0.1 REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION Genes involved in Platelet activation, signaling and aggregation