Results for MCM1
Z-value: 1.79
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Transcription factors associated with MCM1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
MCM1
|
S000004646 | Transcription factor involved in both repression and activation |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YFR055W Show fit | 10.43 |
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner |
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| YPR119W Show fit | 9.55 |
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome |
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| YFR056C Show fit | 9.26 |
Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W |
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| YGR279C Show fit | 8.93 |
Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating |
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| YMR032W Show fit | 8.86 |
Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p |
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| YHR092C Show fit | 8.61 |
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose |
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| YNL160W Show fit | 8.51 |
Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p |
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| YDR133C Show fit | 8.19 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C |
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| YBR067C Show fit | 7.58 |
Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins |
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| YBR092C Show fit | 7.55 |
Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin |
Network of associatons between targets according to the STRING database.
First level regulatory network of MCM1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.9 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 1.7 | 11.8 | GO:0010696 | positive regulation of spindle pole body separation(GO:0010696) |
| 0.9 | 11.2 | GO:0090529 | barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529) |
| 3.5 | 10.4 | GO:0000098 | sulfur amino acid catabolic process(GO:0000098) |
| 0.6 | 8.9 | GO:0006037 | cell wall chitin metabolic process(GO:0006037) |
| 0.3 | 7.7 | GO:0008645 | hexose transport(GO:0008645) monosaccharide transport(GO:0015749) |
| 0.3 | 6.9 | GO:0006096 | glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757) |
| 1.7 | 6.6 | GO:0098742 | agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742) |
| 0.3 | 6.5 | GO:0006885 | regulation of pH(GO:0006885) |
| 1.2 | 5.9 | GO:0032878 | regulation of establishment or maintenance of cell polarity(GO:0032878) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 33.8 | GO:0005576 | extracellular region(GO:0005576) |
| 0.2 | 17.6 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 15.2 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.1 | 13.5 | GO:0000324 | storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324) |
| 3.6 | 10.7 | GO:0030428 | cell septum(GO:0030428) |
| 0.6 | 10.6 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.2 | 9.6 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 2.2 | 8.9 | GO:0044697 | HICS complex(GO:0044697) |
| 2.2 | 8.8 | GO:0030287 | cell wall-bounded periplasmic space(GO:0030287) |
| 0.1 | 8.7 | GO:0005815 | microtubule organizing center(GO:0005815) spindle pole body(GO:0005816) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 24.8 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.1 | 24.7 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.0 | 17.8 | GO:0015926 | glucosidase activity(GO:0015926) |
| 0.7 | 13.0 | GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553) |
| 0.1 | 10.6 | GO:0008092 | cytoskeletal protein binding(GO:0008092) |
| 1.7 | 10.1 | GO:0003993 | acid phosphatase activity(GO:0003993) |
| 2.4 | 9.6 | GO:0015146 | pentose transmembrane transporter activity(GO:0015146) |
| 1.4 | 8.5 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.6 | 7.6 | GO:0005199 | structural constituent of cell wall(GO:0005199) |
| 1.6 | 6.3 | GO:0016634 | oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 0.8 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.3 | 0.8 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.2 | 0.4 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 0.4 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 0.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 0.1 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.2 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 0.1 | 2.6 | REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS | Genes involved in Metabolism of lipids and lipoproteins |
| 0.3 | 2.4 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.2 | 1.6 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.5 | 1.5 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.4 | 1.1 | REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE | Genes involved in NFkB and MAP kinases activation mediated by TLR4 signaling repertoire |
| 0.3 | 0.9 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.3 | 0.9 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.1 | 0.5 | REACTOME APOPTOSIS | Genes involved in Apoptosis |
| 0.0 | 0.5 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |