Results for MBP1
Z-value: 2.64
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Transcription factors associated with MBP1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
MBP1
|
S000002214 | Transcription factor involved in cell cycle progression from G1 to S |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YBL003C Show fit | 17.18 |
One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p |
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| YFR055W Show fit | 16.40 |
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner |
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| YFR056C Show fit | 15.30 |
Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W |
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| YBL085W Show fit | 13.87 |
Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain |
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| YNL178W Show fit | 13.76 |
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins |
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| YER070W Show fit | 11.83 |
One of two large regulatory subunits of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits |
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| YOR315W Show fit | 11.82 |
Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate |
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| YIL053W Show fit | 10.93 |
Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress |
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| YMR199W Show fit | 10.80 |
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) |
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| YOR073W-A Show fit | 9.58 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CDC21/YOR074C; identified by RT-PCR |
Network of associatons between targets according to the STRING database.
First level regulatory network of MBP1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 126.0 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 2.0 | 40.3 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 1.4 | 22.5 | GO:0006407 | rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029) |
| 3.1 | 21.5 | GO:0043137 | DNA replication, removal of RNA primer(GO:0043137) |
| 0.7 | 17.4 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029) |
| 0.1 | 17.3 | GO:0006364 | rRNA processing(GO:0006364) |
| 1.5 | 16.4 | GO:0007109 | obsolete cytokinesis, completion of separation(GO:0007109) |
| 5.4 | 16.1 | GO:0000098 | sulfur amino acid catabolic process(GO:0000098) |
| 4.0 | 16.0 | GO:0031565 | obsolete cytokinesis checkpoint(GO:0031565) |
| 1.4 | 15.6 | GO:0006273 | lagging strand elongation(GO:0006273) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 82.0 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 1.0 | 79.9 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 3.2 | 38.1 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.0 | 30.8 | GO:0005634 | nucleus(GO:0005634) |
| 0.2 | 23.4 | GO:0005935 | cellular bud neck(GO:0005935) |
| 1.3 | 20.0 | GO:0005940 | septin ring(GO:0005940) |
| 1.2 | 16.1 | GO:0031298 | replication fork protection complex(GO:0031298) |
| 0.3 | 14.7 | GO:0030686 | 90S preribosome(GO:0030686) |
| 3.4 | 13.6 | GO:0034990 | mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990) |
| 0.3 | 13.3 | GO:0000131 | incipient cellular bud site(GO:0000131) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 102.0 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.8 | 37.9 | GO:0019843 | rRNA binding(GO:0019843) |
| 1.3 | 37.6 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.2 | 23.8 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.9 | 23.7 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.2 | 20.1 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.3 | 19.2 | GO:0003924 | GTPase activity(GO:0003924) |
| 1.0 | 15.7 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 2.5 | 15.0 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.4 | 15.0 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 7.1 | PID E2F PATHWAY | E2F transcription factor network |
| 1.4 | 4.1 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.5 | 4.0 | PID ATR PATHWAY | ATR signaling pathway |
| 1.0 | 3.0 | PID ATM PATHWAY | ATM pathway |
| 0.6 | 1.9 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.3 | 1.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.6 | 1.2 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.3 | 1.2 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.3 | 1.1 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.4 | 0.9 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 23.8 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 2.7 | 21.8 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 3.9 | 11.6 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 2.8 | 11.2 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 1.4 | 8.4 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.4 | 4.4 | REACTOME G2 M CHECKPOINTS | Genes involved in G2/M Checkpoints |
| 1.4 | 4.1 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.6 | 3.7 | REACTOME LAGGING STRAND SYNTHESIS | Genes involved in Lagging Strand Synthesis |
| 0.3 | 3.6 | REACTOME MITOTIC M M G1 PHASES | Genes involved in Mitotic M-M/G1 phases |
| 0.1 | 2.5 | REACTOME ASPARAGINE N LINKED GLYCOSYLATION | Genes involved in Asparagine N-linked glycosylation |