Results for MATALPHA2
Z-value: 0.60
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Transcription factors associated with MATALPHA2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
MATALPHA2
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S000000635 | Homeobox-domain protein that represses a-specific genes in haploids |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YFL026W Show fit | 2.77 |
Receptor for alpha-factor pheromone; seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells |
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| YKL209C Show fit | 2.73 |
Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells |
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| YBR092C Show fit | 2.40 |
Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin |
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| YIL015W Show fit | 2.36 |
Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest |
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| YGL135W Show fit | 2.26 |
N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Ap and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal |
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| YML056C Show fit | 2.24 |
Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed |
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| YDR033W Show fit | 1.96 |
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p |
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| YBR158W Show fit | 1.83 |
Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN) |
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| YGR148C Show fit | 1.71 |
Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate |
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| YKL165C Show fit | 1.66 |
Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes |
Network of associatons between targets according to the STRING database.
First level regulatory network of MATALPHA2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 21.3 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 1.0 | 5.0 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
| 0.2 | 4.0 | GO:0006633 | fatty acid biosynthetic process(GO:0006633) |
| 0.1 | 3.6 | GO:0006487 | protein N-linked glycosylation(GO:0006487) |
| 0.1 | 3.5 | GO:0006096 | glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757) |
| 0.2 | 3.3 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.2 | 3.3 | GO:0051029 | rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029) |
| 0.0 | 3.1 | GO:0016311 | dephosphorylation(GO:0016311) |
| 0.4 | 2.7 | GO:0030030 | cell projection organization(GO:0030030) cell projection assembly(GO:0030031) |
| 0.2 | 2.5 | GO:0007109 | obsolete cytokinesis, completion of separation(GO:0007109) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.7 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.2 | 11.8 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 7.7 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 0.0 | 6.5 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 1.2 | 4.8 | GO:0030287 | cell wall-bounded periplasmic space(GO:0030287) |
| 0.0 | 3.3 | GO:0005933 | cellular bud(GO:0005933) |
| 0.1 | 3.1 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 2.5 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.1 | 1.8 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.1 | 1.8 | GO:0005844 | polysome(GO:0005844) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 26.2 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.6 | 4.8 | GO:0003938 | IMP dehydrogenase activity(GO:0003938) |
| 0.6 | 3.6 | GO:0003993 | acid phosphatase activity(GO:0003993) |
| 0.9 | 2.8 | GO:0015440 | peptide-transporting ATPase activity(GO:0015440) |
| 0.3 | 2.7 | GO:0070001 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
| 0.1 | 2.7 | GO:0019901 | protein kinase binding(GO:0019901) |
| 0.5 | 2.6 | GO:0017169 | CDP-alcohol phosphatidyltransferase activity(GO:0017169) |
| 0.7 | 2.2 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 0.1 | 2.1 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.1 | 2.0 | GO:0015926 | glucosidase activity(GO:0015926) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.4 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.3 | 1.3 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 0.3 | 1.0 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.2 | 0.4 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.1 | 0.3 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 0.3 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.1 | 0.3 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 0.3 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 0.2 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 0.1 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.1 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.2 | 1.7 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 0.3 | 1.3 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.2 | 1.2 | REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 0.3 | 0.9 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.1 | 0.9 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.2 | 0.8 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 0.7 | REACTOME DNA STRAND ELONGATION | Genes involved in DNA strand elongation |
| 0.2 | 0.6 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.1 | 0.6 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |