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Results for MATALPHA2

Z-value: 0.60

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Transcription factors associated with MATALPHA2

Gene Symbol Gene ID Gene Info
MATALPHA2
S000000635 Homeobox-domain protein that represses a-specific genes in haploids

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MATALPHA2YCR039C-0.723.4e-05Click!

Activity profile of MATALPHA2 motif

Sorted Z-values of MATALPHA2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YFL026W 2.77
STE2
Receptor for alpha-factor pheromone; seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells
YKL209C 2.73
STE6
Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells
YBR092C 2.40
PHO3
Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin
YIL015W 2.36
BAR1
Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest
YGL135W 2.26
RPL1B
N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Ap and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal
YML056C 2.24
IMD4
Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
YDR033W 1.96
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YBR158W 1.83
AMN1
Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YGR148C 1.71
RPL24B
Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YKL165C 1.66
MCD4
Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes
YBR244W 1.65
GPX2
Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YPL131W 1.64
RPL5
Protein component of the large (60S) ribosomal subunit with similarity to E. coli L18 and rat L5 ribosomal proteins; binds 5S rRNA and is required for 60S subunit assembly
YDR098C 1.62
GRX3
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YPR157W 1.48 Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YCR018C 1.46
SRD1
Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YER026C 1.45
CHO1
Phosphatidylserine synthase, functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline
YGR108W 1.40
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YFL027C 1.37
GYP8
GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport
YHR063C 1.37
PAN5
2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE
YEL053W-A 1.35 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YEL054C
YEL020C-B 1.30 Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene YEL020W-A; identified by fungal homology and RT-PCR
YHR216W 1.28
IMD2
Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation
YLR432W 1.28
IMD3
Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
YPR119W 1.26
CLB2
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YNR001W-A 1.24 Dubious open reading frame unlikely to encode a functional protein; identified by homology
YMR003W 1.24
AIM34
Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YHR063W-A 1.23 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER055C 1.20
HIS1
ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
YHR094C 1.19
HXT1
Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YGL032C 1.14
AGA2
Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds
YLR406C 1.13
RPL31B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Ap and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p
YOL101C 1.12
IZH4
Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism
YNL111C 1.12
CYB5
Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
YAR071W 1.10
PHO11
One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
YIL133C 1.10
RPL16A
N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
YPL177C 1.07
CUP9
Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription
YPR048W 1.06
TAH18
Protein with a potential role in DNA replication; displays synthetic lethal genetic interaction with the pol3-13 allele of POL3, which encodes DNA polymerase delta
YMR102C 1.06 Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
YMR049C 1.06
ERB1
Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1
YOR248W 1.03 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YIL169C 1.02 Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene
YLR367W 1.02
RPS22B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Ap and has similarity to E. coli S8 and rat S15a ribosomal proteins
YGR052W 1.01
FMP48
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
YBR177C 1.01
EHT1
Acyl-coenzymeA:ethanol O-acyltransferase that plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane
YOR369C 1.01
RPS12
Protein component of the small (40S) ribosomal subunit; has similarity to rat ribosomal protein S12
YCR102W-A 0.99 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOL049W 0.97
GSH2
Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock
YKL008C 0.95
LAC1
Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p
YOR176W 0.95
HEM15
Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway
YHR123W 0.94
EPT1
sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability
YDR297W 0.94
SUR2
Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis
YGR036C 0.93
CAX4
Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation
YHR143W 0.92
DSE2
Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP
YBR067C 0.92
TIP1
Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
YGL158W 0.91
RCK1
Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations
YBR252W 0.91
DUT1
dUTPase, catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability
YCR034W 0.91
FEN1
Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway
YEL027W 0.90
CUP5
Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis
YIL158W 0.90
AIM20
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YER049W 0.89
TPA1
Protein of unknown function; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; has a role in translation termination efficiency, mRNA poly(A) tail length and mRNA stability
YOL086C 0.89
ADH1
Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YLR167W 0.88
RPS31
Fusion protein that is cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B
YGL067W 0.87
NPY1
NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes
YAL059W 0.85
ECM1
Protein of unknown function, localized in the nucleoplasm and the nucleolus, genetically interacts with MTR2 in 60S ribosomal protein subunit export
YJL011C 0.85
RPC17
RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex
YGL029W 0.85
CGR1
Protein involved in nucleolar integrity and processing of the pre-rRNA for the 60S ribosome subunit; transcript is induced in response to cytotoxic stress but not genotoxic stress
YGR192C 0.84
TDH3
Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
YFR032C 0.84 Putative protein of unknown function; transcribed during sporulation; YFR032C is not an essential gene
YGL201C 0.81
MCM6
Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YOR175C 0.81
ALE1
Lysophospholipid acyltransferase, partially redundant with Slc1p; part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids
YNL148C 0.81
ALF1
Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance
YGL209W 0.81
MIG2
Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter
YJR009C 0.80
TDH2
Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
YGR050C 0.80 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIR020C-B 0.80 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF MRS1
YJR070C 0.79
LIA1
Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyses hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning
YHL003C 0.79
LAG1
Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p
YPR041W 0.79
TIF5
Translation initiation factor eIF-5; N-terminal domain functions as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP; C-terminal domain is the core of ribosomal preinitiation complex formation
YPL227C 0.78
ALG5
UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum
YJR071W 0.76 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR249W 0.76
YEF3
Translational elongation factor 3, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex; contains two ABC cassettes; binds and hydrolyses ATP
YBR031W 0.75
RPL4A
N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Bp and has similarity to E. coli L4 and rat L4 ribosomal proteins
YER137C 0.74 Putative protein of unknown function
YMR143W 0.74
RPS16A
Protein component of the small (40S) ribosomal subunit; identical to Rps16Bp and has similarity to E. coli S9 and rat S16 ribosomal proteins
YPR010C 0.74
RPA135
RNA polymerase I subunit A135
YGR040W 0.72
KSS1
Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
YGL097W 0.72
SRM1
Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
YDR215C 0.72 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein
YHR141C 0.71
RPL42B
Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to rat L44; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus
YJL097W 0.71
PHS1
Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane, involved in elongation of very long-chain fatty acids; evolutionarily conserved, similar to mammalian PTPLA and PTPLB; involved in sphingolipid biosynthesis and protein trafficking
YJR094W-A 0.71
RPL43B
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YDR101C 0.71
ARX1
Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
YKL216W 0.71
URA1
Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid
YEL029C 0.71
BUD16
Putative pyridoxal kinase, key enzyme in vitamin B6 metabolism; involved in maintaining levels of pyridoxal 5'-phosphate, the active form of vitamin B6; required for genome integrity; homolog of E. coli PdxK; involved in bud-site selection
YPR029C 0.71
APL4
Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
YML124C 0.71
TUB3
Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p
YIL029C 0.71 Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YGL120C 0.70
PRP43
RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome
YCR104W 0.68
PAU3
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YGR060W 0.67
ERG25
C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol
YCR022C 0.67 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene
YPL041C 0.67 Protein of unknown function involved in maintenance of proper telomere length
YLR411W 0.67
CTR3
High-affinity copper transporter of the plasma membrane, acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae
YPR146C 0.66 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR293W 0.66
RPS10A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Bp and has similarity to rat ribosomal protein S10
YMR208W 0.66
ERG12
Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
YDR413C 0.66 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the essential uncharacterized ORF YDR412W that is implicated in rRNA processing
YDL055C 0.66
PSA1
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YIL096C 0.66 Putative protein of unknown function; associates with precursors of the 60S ribosomal subunit
YDL240W 0.65
LRG1
Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis
YMR142C 0.65
RPL13B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Ap; not essential for viability; has similarity to rat L13 ribosomal protein
YCR009C 0.65
RVS161
Amphiphysin-like lipid raft protein; subunit of a complex (Rvs161p-Rvs167p) that regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress
YOL103W 0.65
ITR2
Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively
YLR257W 0.65 Putative protein of unknown function
YGL039W 0.65 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YDR037W 0.64
KRS1
Lysyl-tRNA synthetase; also identified as a negative regulator of general control of amino acid biosynthesis
YHR060W 0.64
VMA22
Peripheral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)
YKL219W 0.64
COS9
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YNL300W 0.63 Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid
YCR012W 0.63
PGK1
3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
YKR003W 0.63
OSH6
Member of an oxysterol-binding protein family with overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery
YHR031C 0.62
RRM3
DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p
YHR045W 0.62 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
YDL111C 0.62
RRP42
Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex with Rrp4p, Rrp41p, Rrp43p and Dis3p
YNL066W 0.61
SUN4
Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family
YBR066C 0.61
NRG2
Transcriptional repressor that mediates glucose repression and negatively regulates filamentous growth; has similarity to Nrg1p
YGL076C 0.61
RPL7A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Bp and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)
YJL200C 0.61
ACO2
Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
YBR022W 0.60
POA1
Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing
YLR328W 0.60
NMA1
Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways
YPR170W-A 0.60 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry
YLR154C 0.60
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YPL225W 0.59 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YER012W 0.58
PRE1
Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
YKL120W 0.58
OAC1
Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, and thiosulfate; member of the mitochondrial carrier family
YNL301C 0.57
RPL18B
Protein component of the large (60S) ribosomal subunit, identical to Rpl18Ap and has similarity to rat L18 ribosomal protein
YDR509W 0.57 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR273C 0.57
TPO4
Polyamine transport protein, recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily
YNR067C 0.57
DSE4
Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother
YLR022C 0.57
SDO1
Essential protein involved in 60S ribosome maturation; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archae and eukaryotes
YDR492W 0.56
IZH1
Membrane protein involved in zinc metabolism, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc
YDR185C 0.56 Mitochondrial protein of unknown function; has similarity to Ups1p, which is involved in regulation of alternative topogenesis of the dynamin-related GTPase Mgm1p
YLR196W 0.56
PWP1
Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily
YDL201W 0.56
TRM8
Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA
YER056C-A 0.55
RPL34A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Bp and has similarity to rat L34 ribosomal protein
YDR491C 0.55 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL153C 0.55
INO1
Inositol 1-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
YDR353W 0.54
TRR1
Cytoplasmic thioredoxin reductase, key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress
YKL096W-A 0.54
CWP2
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YIL011W 0.54
TIR3
Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth
YDR508C 0.54
GNP1
High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids
YKL063C 0.54 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
YDR447C 0.54
RPS17B
Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Ap and has similarity to rat S17 ribosomal protein
YNR054C 0.54
ESF2
Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
YKL110C 0.53
KTI12
Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YGR164W 0.53 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR170W-B 0.53 Putative protein of unknown function, conserved in fungi; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C
YPL241C 0.53
CIN2
GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
YBR243C 0.52
ALG7
UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
YJL091C 0.52
GWT1
Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors
YLR222C 0.52
UTP13
Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YFR039C 0.52 Putative protein of unknown function; may be involved in response to high salt and changes in carbon source
YCR045C 0.52 Putative protein of unknown function
YGL069C 0.51 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 92% of ORF overlaps the uncharacterized ORF YGL068W; deletion in cyr1 mutant results in loss of stress resistance
YER118C 0.51
SHO1
Transmembrane osmosensor, participates in activation of both the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway
YCL024W 0.51
KCC4
Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p
YNL178W 0.51
RPS3
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YGL028C 0.51
SCW11
Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p
YOR101W 0.51
RAS1
GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes
YDR434W 0.51
GPI17
Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Sp homolog
YMR108W 0.51
ILV2
Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control
YLR132C 0.51 Protein of unknown function; green fluorescent protein (GFP)-tagged protein localizes to mitochondria and nucleus; YLR132C is an essential gene
YDR212W 0.51
TCP1
Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in maintenance of actin cytoskeleton; homolog to Drosophila melanogaster and mouse tailless complex polypeptide
YPL235W 0.50
RVB2
Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; member of the RUVB-like protein family
YER134C 0.50 Putative protein of unknown function; non-essential gene
YMR319C 0.49
FET4
Low-affinity Fe(II) transporter of the plasma membrane
YGL040C 0.49
HEM2
Delta-aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen, the second step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus
YOR108C-A 0.49 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YOL057W 0.49 Putative metalloprotease
YNL028W 0.48 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YML119W 0.48 Putative protein of unknown funtion; YML119W is not an essential gene; potential Cdc28p substrate
YGR075C 0.48
PRP38
Unique component of the U4/U6.U5 tri-snRNP particle, required for conformational changes which result in the catalytic activation of the spliceosome; dispensible for spliceosome assembly
YBR121C 0.48
GRS1
Cytoplasmic and mitochondrial glycyl-tRNA synthase that ligates glycine to the cognate anticodon bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation
YJL169W 0.48 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2
YNL147W 0.47
LSM7
Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YDR284C 0.47
DPP1
Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism
YDL235C 0.47
YPD1
Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus
YBL077W 0.47 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C
YCR102C 0.46 Putative protein of unknown function; involved in copper metabolism; similar to C.carbonum toxD gene; YCR102C is not an essential gene
YGR157W 0.46
CHO2
Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis
YBR048W 0.46
RPS11B
Protein component of the small (40S) ribosomal subunit; identical to Rps11Ap and has similarity to E. coli S17 and rat S11 ribosomal proteins
YDR539W 0.46 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR539W is not an essential gene; homolog of E. coli UbiD
YJR047C 0.46
ANB1
Translation initiation factor eIF-5A, promotes formation of the first peptide bond; similar to and functionally redundant with Hyp2p; undergoes an essential hypusination modification; expressed under anaerobic conditions
YBL087C 0.46
RPL23A
Protein component of the large (60S) ribosomal subunit, identical to Rpl23Bp and has similarity to E. coli L14 and rat L23 ribosomal proteins
YOL056W 0.46
GPM3
Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
YBR210W 0.45
ERV15
Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p
YER003C 0.45
PMI40
Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation
YMR119W 0.45
ASI1
Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals
YOL088C 0.45
MPD2
Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p
YPL143W 0.44
RPL33A
N-terminally acetylated ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Bp and has similarity to rat L35a; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable

Network of associatons between targets according to the STRING database.

First level regulatory network of MATALPHA2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 5.0 GO:0006177 GMP biosynthetic process(GO:0006177)
0.5 1.4 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.4 1.7 GO:0015867 ATP transport(GO:0015867)
0.4 2.7 GO:0030030 cell projection organization(GO:0030030) cell projection assembly(GO:0030031)
0.4 1.1 GO:0035955 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
0.4 1.1 GO:0019673 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
0.4 1.1 GO:0009177 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) deoxyribonucleoside monophosphate metabolic process(GO:0009162) pyrimidine deoxyribonucleoside monophosphate metabolic process(GO:0009176) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177)
0.3 2.4 GO:0043171 peptide catabolic process(GO:0043171)
0.3 1.4 GO:0042256 mature ribosome assembly(GO:0042256)
0.3 2.3 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
0.3 1.3 GO:0006657 CDP-choline pathway(GO:0006657)
0.3 1.2 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.3 1.2 GO:0030497 fatty acid elongation(GO:0030497)
0.3 1.2 GO:2001057 reactive nitrogen species metabolic process(GO:2001057)
0.3 0.8 GO:0006021 inositol biosynthetic process(GO:0006021)
0.3 1.8 GO:0006672 ceramide metabolic process(GO:0006672) ceramide biosynthetic process(GO:0046513)
0.3 1.0 GO:0000296 spermine transport(GO:0000296)
0.2 1.0 GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000461)
0.2 0.7 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.2 3.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.2 0.9 GO:0014070 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
0.2 2.5 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
0.2 0.9 GO:0046490 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490)
0.2 0.8 GO:0098610 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.2 3.3 GO:0051029 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
0.2 0.6 GO:0060988 lipid tube assembly(GO:0060988) protein-lipid complex assembly(GO:0065005) protein-lipid complex subunit organization(GO:0071825)
0.2 2.3 GO:0015833 peptide transport(GO:0015833)
0.2 0.8 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.2 1.5 GO:0015939 pantothenate metabolic process(GO:0015939) pantothenate biosynthetic process(GO:0015940)
0.2 0.7 GO:0019184 glutathione biosynthetic process(GO:0006750) nonribosomal peptide biosynthetic process(GO:0019184)
0.2 0.3 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.2 1.7 GO:0055069 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.2 1.7 GO:0006547 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.2 21.3 GO:0002181 cytoplasmic translation(GO:0002181)
0.2 0.5 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.2 4.0 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.2 0.5 GO:0046901 tetrahydrofolylpolyglutamate metabolic process(GO:0046900) tetrahydrofolylpolyglutamate biosynthetic process(GO:0046901)
0.2 0.6 GO:1900436 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
0.2 0.5 GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)(GO:0000388)
0.2 1.9 GO:0006415 translational termination(GO:0006415)
0.2 0.5 GO:0051439 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.2 0.6 GO:0009423 chorismate biosynthetic process(GO:0009423)
0.1 0.7 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.1 0.6 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
0.1 0.6 GO:0046655 folic acid metabolic process(GO:0046655) folic acid biosynthetic process(GO:0046656)
0.1 0.4 GO:0090338 regulation of formin-nucleated actin cable assembly(GO:0090337) positive regulation of formin-nucleated actin cable assembly(GO:0090338)
0.1 0.4 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.1 0.7 GO:0072668 obsolete tubulin complex biogenesis(GO:0072668)
0.1 1.1 GO:0015677 copper ion import(GO:0015677)
0.1 0.5 GO:0018196 peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279)
0.1 1.7 GO:0030011 maintenance of cell polarity(GO:0030011)
0.1 0.1 GO:0009135 purine nucleoside diphosphate metabolic process(GO:0009135) purine ribonucleoside diphosphate metabolic process(GO:0009179) ribonucleoside diphosphate metabolic process(GO:0009185) ADP metabolic process(GO:0046031)
0.1 0.4 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.1 1.2 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.1 0.1 GO:0045901 positive regulation of translational elongation(GO:0045901)
0.1 3.5 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.1 0.5 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
0.1 0.4 GO:0006798 polyphosphate catabolic process(GO:0006798)
0.1 0.5 GO:0043097 pyrimidine ribonucleotide salvage(GO:0010138) pyrimidine nucleotide salvage(GO:0032262) pyrimidine nucleoside salvage(GO:0043097) UMP salvage(GO:0044206)
0.1 0.6 GO:0070813 hydrogen sulfide metabolic process(GO:0070813) hydrogen sulfide biosynthetic process(GO:0070814)
0.1 0.8 GO:0000743 nuclear migration involved in conjugation with cellular fusion(GO:0000743)
0.1 0.4 GO:0030541 plasmid partitioning(GO:0030541)
0.1 0.8 GO:0032988 ribonucleoprotein complex disassembly(GO:0032988)
0.1 1.8 GO:0006734 NADH metabolic process(GO:0006734)
0.1 0.6 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.1 0.3 GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000448)
0.1 1.0 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 3.6 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.1 0.3 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
0.1 0.8 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.1 0.2 GO:0008655 pyrimidine-containing compound salvage(GO:0008655)
0.1 0.3 GO:0071478 cellular response to radiation(GO:0071478) cellular response to light stimulus(GO:0071482)
0.1 0.7 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.1 0.4 GO:0009164 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.1 0.5 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.1 0.1 GO:0061422 response to cold(GO:0009409) positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH(GO:0061422) cellular response to cold(GO:0070417)
0.1 0.5 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.1 0.7 GO:0009312 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.1 0.1 GO:0043065 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.1 0.6 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.1 0.4 GO:1904357 negative regulation of telomere maintenance via telomerase(GO:0032211) negative regulation of telomere maintenance via telomere lengthening(GO:1904357)
0.1 0.8 GO:0006783 porphyrin-containing compound biosynthetic process(GO:0006779) heme biosynthetic process(GO:0006783) tetrapyrrole biosynthetic process(GO:0033014)
0.1 0.6 GO:0015791 polyol transport(GO:0015791)
0.1 0.8 GO:0032508 DNA duplex unwinding(GO:0032508)
0.1 1.3 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 0.1 GO:0007535 donor selection(GO:0007535)
0.1 1.0 GO:0007120 axial cellular bud site selection(GO:0007120)
0.1 0.5 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.1 0.1 GO:1901352 regulation of phosphatidylglycerol biosynthetic process(GO:1901351) negative regulation of phosphatidylglycerol biosynthetic process(GO:1901352)
0.1 0.4 GO:0071450 response to superoxide(GO:0000303) response to oxygen radical(GO:0000305) removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.1 0.6 GO:0006797 polyphosphate metabolic process(GO:0006797)
0.1 0.1 GO:0042990 regulation of transcription factor import into nucleus(GO:0042990) negative regulation of transcription factor import into nucleus(GO:0042992)
0.1 0.5 GO:0009099 valine biosynthetic process(GO:0009099)
0.1 0.6 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 0.3 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.1 0.4 GO:0034503 protein localization to nucleolar rDNA repeats(GO:0034503)
0.1 0.8 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.1 1.2 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.1 0.2 GO:0008272 sulfate transport(GO:0008272)
0.1 0.5 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.1 0.3 GO:0060188 regulation of protein desumoylation(GO:0060188)
0.1 0.5 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.1 0.2 GO:0000915 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin structure organization(GO:0031032) actomyosin contractile ring organization(GO:0044837)
0.1 0.5 GO:0009636 response to toxic substance(GO:0009636)
0.1 1.3 GO:0006448 regulation of translational elongation(GO:0006448)
0.1 0.4 GO:0015780 nucleotide-sugar transport(GO:0015780)
0.1 0.7 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.1 0.5 GO:0000372 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.1 2.0 GO:0016126 steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126)
0.1 1.8 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.1 0.2 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.1 0.4 GO:0009098 leucine biosynthetic process(GO:0009098)
0.1 1.7 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.1 0.2 GO:0015809 arginine transport(GO:0015809)
0.1 0.5 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.1 0.3 GO:0034473 U1 snRNA 3'-end processing(GO:0034473)
0.1 1.1 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.1 0.3 GO:0030834 regulation of actin filament depolymerization(GO:0030834) negative regulation of actin filament depolymerization(GO:0030835) barbed-end actin filament capping(GO:0051016) actin filament capping(GO:0051693)
0.1 0.3 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) negative regulation of actin nucleation(GO:0051126)
0.1 0.3 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity(GO:0051090)
0.1 0.5 GO:0007323 peptide pheromone maturation(GO:0007323)
0.1 0.4 GO:0007030 Golgi organization(GO:0007030)
0.1 0.2 GO:0070637 nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637)
0.1 0.1 GO:0016114 terpenoid metabolic process(GO:0006721) terpenoid biosynthetic process(GO:0016114) farnesyl diphosphate biosynthetic process(GO:0045337) farnesyl diphosphate metabolic process(GO:0045338)
0.1 0.2 GO:0000042 protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.1 0.2 GO:1900101 regulation of endoplasmic reticulum unfolded protein response(GO:1900101)
0.1 0.4 GO:0001402 signal transduction involved in filamentous growth(GO:0001402)
0.1 0.3 GO:0009263 deoxyribonucleotide metabolic process(GO:0009262) deoxyribonucleotide biosynthetic process(GO:0009263)
0.1 0.5 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.1 0.5 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.1 0.2 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
0.1 0.2 GO:0031554 regulation of DNA-templated transcription, termination(GO:0031554)
0.1 0.2 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.1 0.2 GO:2000134 negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.1 0.6 GO:0070651 nonfunctional rRNA decay(GO:0070651)
0.1 0.2 GO:1902223 L-phenylalanine biosynthetic process(GO:0009094) erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process(GO:1902223)
0.1 0.2 GO:0090110 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.1 0.1 GO:0006020 inositol metabolic process(GO:0006020)
0.1 1.3 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.1 1.5 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 0.3 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 0.3 GO:0019935 cAMP-mediated signaling(GO:0019933) cyclic-nucleotide-mediated signaling(GO:0019935)
0.1 0.2 GO:0048279 vesicle fusion with endoplasmic reticulum(GO:0048279)
0.1 0.8 GO:0043094 cellular metabolic compound salvage(GO:0043094)
0.1 0.6 GO:0000917 barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529)
0.1 0.2 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.1 0.2 GO:0031590 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.1 0.2 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.1 0.5 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1 2.2 GO:0043087 regulation of GTPase activity(GO:0043087)
0.1 0.2 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.0 0.3 GO:0000022 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231)
0.0 0.1 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.4 GO:0055070 cellular copper ion homeostasis(GO:0006878) copper ion homeostasis(GO:0055070)
0.0 0.1 GO:0019401 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.0 0.0 GO:0042542 response to hydrogen peroxide(GO:0042542)
0.0 0.2 GO:0030847 termination of RNA polymerase II transcription, exosome-dependent(GO:0030847)
0.0 0.1 GO:0045141 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.0 0.2 GO:0007234 osmosensory signaling via phosphorelay pathway(GO:0007234)
0.0 0.3 GO:0006814 sodium ion transport(GO:0006814)
0.0 0.3 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 3.1 GO:0016311 dephosphorylation(GO:0016311)
0.0 1.0 GO:0006885 regulation of pH(GO:0006885)
0.0 0.0 GO:0006531 aspartate metabolic process(GO:0006531)
0.0 0.2 GO:0010907 positive regulation of glucose metabolic process(GO:0010907) positive regulation of gluconeogenesis(GO:0045722)
0.0 0.2 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.0 0.2 GO:0022615 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0 0.2 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.0 0.6 GO:0018208 protein peptidyl-prolyl isomerization(GO:0000413) peptidyl-proline modification(GO:0018208)
0.0 0.2 GO:0006829 zinc II ion transport(GO:0006829)
0.0 0.7 GO:0030472 mitotic spindle organization in nucleus(GO:0030472)
0.0 0.1 GO:0033262 regulation of nuclear cell cycle DNA replication(GO:0033262)
0.0 0.1 GO:0015848 spermidine transport(GO:0015848)
0.0 0.9 GO:0042255 ribosome assembly(GO:0042255)
0.0 0.1 GO:0009090 homoserine biosynthetic process(GO:0009090)
0.0 0.0 GO:0051596 methylglyoxal metabolic process(GO:0009438) methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0 0.9 GO:1903509 liposaccharide metabolic process(GO:1903509)
0.0 0.1 GO:0042538 hyperosmotic salinity response(GO:0042538)
0.0 0.1 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 0.3 GO:0006144 purine nucleobase metabolic process(GO:0006144)
0.0 0.2 GO:0043489 RNA stabilization(GO:0043489) mRNA stabilization(GO:0048255)
0.0 0.6 GO:0046474 glycerophospholipid biosynthetic process(GO:0046474)
0.0 0.5 GO:0042797 tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0 0.1 GO:0045013 carbon catabolite repression of transcription(GO:0045013)
0.0 0.4 GO:0033673 negative regulation of protein kinase activity(GO:0006469) negative regulation of kinase activity(GO:0033673)
0.0 0.5 GO:0006915 apoptotic process(GO:0006915) cell death(GO:0008219) programmed cell death(GO:0012501)
0.0 0.2 GO:0006874 cellular calcium ion homeostasis(GO:0006874) calcium ion homeostasis(GO:0055074)
0.0 0.2 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.0 0.3 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.0 0.3 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.4 GO:0051668 localization within membrane(GO:0051668)
0.0 0.1 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.0 0.1 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.3 GO:0031070 intronic snoRNA processing(GO:0031070) intronic box C/D snoRNA processing(GO:0034965)
0.0 0.2 GO:0006903 vesicle targeting(GO:0006903) vesicle tethering involved in exocytosis(GO:0090522)
0.0 0.3 GO:0006038 cell wall chitin biosynthetic process(GO:0006038)
0.0 0.1 GO:0071406 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
0.0 0.1 GO:0042401 tryptophan biosynthetic process(GO:0000162) amine biosynthetic process(GO:0009309) cellular biogenic amine biosynthetic process(GO:0042401) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
0.0 0.3 GO:0006526 arginine biosynthetic process(GO:0006526)
0.0 0.2 GO:0060631 regulation of meiosis I(GO:0060631)
0.0 0.1 GO:0001015 snoRNA transcription from an RNA polymerase II promoter(GO:0001015) snoRNA transcription(GO:0009302)
0.0 0.1 GO:0000967 rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471)
0.0 0.8 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.0 0.1 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143)
0.0 0.1 GO:0034198 cellular response to amino acid starvation(GO:0034198)
0.0 0.1 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.0 0.4 GO:0001300 chronological cell aging(GO:0001300)
0.0 0.0 GO:0045017 glycerolipid biosynthetic process(GO:0045017)
0.0 0.0 GO:0030846 termination of RNA polymerase II transcription, poly(A)-coupled(GO:0030846)
0.0 0.1 GO:0031134 sister chromatid biorientation(GO:0031134)
0.0 0.1 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0 0.2 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.2 GO:0006743 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) ketone biosynthetic process(GO:0042181) quinone metabolic process(GO:1901661) quinone biosynthetic process(GO:1901663)
0.0 0.1 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.0 0.1 GO:0035753 maintenance of DNA trinucleotide repeats(GO:0035753)
0.0 0.1 GO:0043488 regulation of RNA stability(GO:0043487) regulation of mRNA stability(GO:0043488)
0.0 0.2 GO:0006999 nuclear pore organization(GO:0006999)
0.0 0.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.1 GO:0010674 negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010674)
0.0 0.3 GO:0002098 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.0 0.2 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 0.1 GO:0040031 snRNA pseudouridine synthesis(GO:0031120) snRNA modification(GO:0040031)
0.0 0.1 GO:0009088 threonine biosynthetic process(GO:0009088)
0.0 0.0 GO:0034724 DNA replication-independent nucleosome organization(GO:0034724)
0.0 0.3 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.1 GO:0018202 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183) peptidyl-histidine modification(GO:0018202)
0.0 0.0 GO:0001522 pseudouridine synthesis(GO:0001522)
0.0 0.1 GO:0016075 rRNA catabolic process(GO:0016075)
0.0 0.1 GO:0048478 replication fork protection(GO:0048478)
0.0 0.1 GO:0006771 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.0 0.2 GO:0034249 negative regulation of cellular amide metabolic process(GO:0034249)
0.0 0.0 GO:0042726 flavin-containing compound metabolic process(GO:0042726) flavin-containing compound biosynthetic process(GO:0042727)
0.0 0.1 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.0 0.0 GO:0001109 promoter clearance during DNA-templated transcription(GO:0001109) promoter clearance from RNA polymerase II promoter(GO:0001111)
0.0 0.2 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.0 GO:1901985 positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0 0.0 GO:0006037 cell wall chitin metabolic process(GO:0006037)
0.0 0.0 GO:0045926 negative regulation of growth(GO:0045926) negative regulation of filamentous growth(GO:0060258)
0.0 0.2 GO:0006893 Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.0 0.1 GO:0045002 double-strand break repair via single-strand annealing(GO:0045002)
0.0 0.1 GO:0009395 phospholipid catabolic process(GO:0009395)
0.0 0.2 GO:0071900 regulation of protein serine/threonine kinase activity(GO:0071900)
0.0 0.1 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.1 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.1 GO:0010526 negative regulation of transposition, RNA-mediated(GO:0010526) negative regulation of transposition(GO:0010529)
0.0 0.1 GO:0016074 snoRNA metabolic process(GO:0016074)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.8 GO:0030287 cell wall-bounded periplasmic space(GO:0030287)
0.4 1.7 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.4 1.1 GO:0070545 PeBoW complex(GO:0070545)
0.3 0.8 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.2 0.7 GO:0005827 polar microtubule(GO:0005827) tubulin complex(GO:0045298)
0.2 18.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 0.4 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.2 0.6 GO:0072687 meiotic spindle(GO:0072687)
0.2 11.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 0.6 GO:0030428 cell septum(GO:0030428)
0.2 1.0 GO:0034456 UTP-C complex(GO:0034456)
0.2 0.6 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.2 0.6 GO:0070209 ASTRA complex(GO:0070209)
0.1 0.9 GO:0042555 MCM complex(GO:0042555)
0.1 0.4 GO:0071261 Ssh1 translocon complex(GO:0071261)
0.1 0.4 GO:0031415 NatA complex(GO:0031415)
0.1 0.5 GO:0044697 HICS complex(GO:0044697)
0.1 0.5 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.1 0.5 GO:0005797 Golgi medial cisterna(GO:0005797)
0.1 0.7 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.1 0.5 GO:0042597 periplasmic space(GO:0042597)
0.1 1.7 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 1.1 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 0.1 GO:0030658 transport vesicle membrane(GO:0030658)
0.1 0.8 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.1 0.7 GO:0031933 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.1 1.5 GO:0022626 cytosolic ribosome(GO:0022626)
0.1 0.7 GO:0072686 mitotic spindle(GO:0072686)
0.1 0.9 GO:0033553 rDNA heterochromatin(GO:0033553)
0.1 0.5 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.1 0.6 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.1 1.4 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 0.6 GO:0048500 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.1 0.8 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 0.4 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.1 0.3 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
0.1 1.0 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 0.4 GO:0034518 RNA cap binding complex(GO:0034518)
0.1 0.5 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.1 0.3 GO:0030874 nucleolar chromatin(GO:0030874)
0.1 0.7 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.1 3.1 GO:0005811 lipid particle(GO:0005811)
0.1 0.3 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.1 0.1 GO:0051233 spindle midzone(GO:0051233)
0.1 0.2 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205) Sec62/Sec63 complex(GO:0031207)
0.1 0.3 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1 0.9 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 0.2 GO:0005880 nuclear microtubule(GO:0005880)
0.1 0.2 GO:0030133 transport vesicle(GO:0030133)
0.1 0.2 GO:0000837 Doa10p ubiquitin ligase complex(GO:0000837)
0.1 1.0 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 0.6 GO:0005688 U6 snRNP(GO:0005688)
0.1 0.2 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 0.5 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 1.8 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 0.3 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.1 0.5 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 0.3 GO:0035859 Seh1-associated complex(GO:0035859)
0.1 0.3 GO:0070860 RNA polymerase I core factor complex(GO:0070860)
0.1 2.5 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 0.3 GO:0030892 mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990)
0.1 1.8 GO:0005844 polysome(GO:0005844)
0.1 0.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.2 GO:0032432 actin filament bundle(GO:0032432)
0.1 0.2 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 1.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 0.8 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.1 0.2 GO:0097344 Rix1 complex(GO:0097344)
0.1 0.3 GO:0030689 Noc complex(GO:0030689)
0.1 0.4 GO:0033180 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 0.2 GO:0043529 GET complex(GO:0043529)
0.1 0.2 GO:0005791 rough endoplasmic reticulum(GO:0005791) rough endoplasmic reticulum membrane(GO:0030867)
0.1 0.3 GO:0005871 kinesin complex(GO:0005871)
0.1 0.6 GO:0005940 septin ring(GO:0005940)
0.1 0.2 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 0.4 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.1 0.2 GO:0044462 cell wall part(GO:0044426) external encapsulating structure part(GO:0044462)
0.1 0.1 GO:0044453 nuclear membrane part(GO:0044453)
0.1 0.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.2 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.1 0.2 GO:0000417 HIR complex(GO:0000417)
0.1 0.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.2 GO:0031414 N-terminal protein acetyltransferase complex(GO:0031414)
0.0 1.1 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 0.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.4 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.2 GO:0000444 MIS12/MIND type complex(GO:0000444) nuclear MIS12/MIND complex(GO:0000818)
0.0 0.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.3 GO:0000974 Prp19 complex(GO:0000974)
0.0 7.7 GO:0005794 Golgi apparatus(GO:0005794)
0.0 0.1 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.3 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.2 GO:0032040 small-subunit processome(GO:0032040)
0.0 0.1 GO:0032807 DNA ligase IV complex(GO:0032807)
0.0 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.3 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.3 GO:0005884 actin filament(GO:0005884)
0.0 0.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.2 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 0.1 GO:0000814 ESCRT II complex(GO:0000814)
0.0 0.2 GO:0000145 exocyst(GO:0000145)
0.0 1.1 GO:0030686 90S preribosome(GO:0030686)
0.0 0.2 GO:0017059 palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211) SPOTS complex(GO:0035339)
0.0 0.2 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.0 GO:0031391 Elg1 RFC-like complex(GO:0031391)
0.0 0.1 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.3 GO:0005655 nucleolar ribonuclease P complex(GO:0005655) multimeric ribonuclease P complex(GO:0030681)
0.0 6.5 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 0.1 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851) guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.1 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967) pyruvate dehydrogenase complex(GO:0045254)
0.0 1.1 GO:0005874 microtubule(GO:0005874)
0.0 0.2 GO:0035097 histone methyltransferase complex(GO:0035097) Set1C/COMPASS complex(GO:0048188)
0.0 3.3 GO:0005933 cellular bud(GO:0005933)
0.0 0.2 GO:0000346 transcription export complex(GO:0000346)
0.0 0.1 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.1 GO:0000811 GINS complex(GO:0000811)
0.0 0.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.0 GO:0000131 incipient cellular bud site(GO:0000131)
0.0 0.4 GO:0097526 U4/U6 x U5 tri-snRNP complex(GO:0046540) spliceosomal tri-snRNP complex(GO:0097526)
0.0 0.1 GO:0033597 mitotic checkpoint complex(GO:0033597)
0.0 0.0 GO:0044284 mitochondrial crista junction(GO:0044284)
0.0 0.0 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.1 GO:0036452 ESCRT complex(GO:0036452)
0.0 0.0 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.0 0.0 GO:0032301 MutSalpha complex(GO:0032301)
0.0 0.1 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.0 GO:0000786 nucleosome(GO:0000786)
0.0 0.1 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 0.1 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.2 GO:0044445 cytosolic part(GO:0044445)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.8 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.9 2.8 GO:0015440 peptide-transporting ATPase activity(GO:0015440)
0.7 2.2 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.6 1.9 GO:0008097 5S rRNA binding(GO:0008097)
0.6 3.6 GO:0003993 acid phosphatase activity(GO:0003993)
0.5 1.6 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.5 1.6 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.5 2.6 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.4 1.8 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.4 1.7 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.4 1.2 GO:0009922 fatty acid elongase activity(GO:0009922)
0.4 1.6 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
0.3 2.7 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.3 1.6 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.3 0.8 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.3 1.1 GO:0042973 glucan endo-1,3-beta-D-glucosidase activity(GO:0042973)
0.3 0.8 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.3 1.0 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.3 0.3 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825)
0.3 1.0 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
0.2 0.7 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.2 1.4 GO:0070300 phosphatidic acid binding(GO:0070300)
0.2 0.9 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.2 0.7 GO:0070568 guanylyltransferase activity(GO:0070568)
0.2 0.6 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.2 0.6 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
0.2 0.8 GO:0009378 four-way junction helicase activity(GO:0009378)
0.2 1.0 GO:0004026 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.2 1.2 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.2 0.8 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.2 0.7 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.2 1.1 GO:0016408 C-acyltransferase activity(GO:0016408)
0.2 0.5 GO:0000339 RNA cap binding(GO:0000339)
0.2 0.5 GO:0016504 peptidase activator activity(GO:0016504)
0.2 1.2 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.2 0.5 GO:0004326 tetrahydrofolylpolyglutamate synthase activity(GO:0004326)
0.2 0.5 GO:0016872 intramolecular lyase activity(GO:0016872)
0.2 0.8 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.2 0.5 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
0.2 0.8 GO:0004707 MAP kinase activity(GO:0004707)
0.1 1.3 GO:0010181 FMN binding(GO:0010181)
0.1 2.1 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 1.3 GO:0005216 ion channel activity(GO:0005216)
0.1 0.1 GO:0032296 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.1 0.4 GO:0005302 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.1 0.4 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.1 26.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 0.4 GO:0008242 omega peptidase activity(GO:0008242)
0.1 0.5 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.1 0.4 GO:0016433 rRNA (adenine) methyltransferase activity(GO:0016433)
0.1 0.6 GO:0043139 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.1 2.7 GO:0019901 protein kinase binding(GO:0019901)
0.1 1.1 GO:0001056 RNA polymerase III activity(GO:0001056)
0.1 2.0 GO:0015926 glucosidase activity(GO:0015926)
0.1 1.1 GO:0004497 monooxygenase activity(GO:0004497)
0.1 0.8 GO:0019238 cyclohydrolase activity(GO:0019238)
0.1 0.1 GO:0004362 glutathione-disulfide reductase activity(GO:0004362)
0.1 1.0 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.1 1.8 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.1 1.3 GO:0005199 structural constituent of cell wall(GO:0005199)
0.1 0.4 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 1.0 GO:0030276 clathrin binding(GO:0030276)
0.1 1.7 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.1 1.2 GO:0070566 adenylyltransferase activity(GO:0070566)
0.1 0.3 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.1 0.5 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 0.6 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.1 0.5 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.1 1.4 GO:0001054 RNA polymerase I activity(GO:0001054)
0.1 0.8 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 0.3 GO:0051219 phosphoprotein binding(GO:0051219)
0.1 0.3 GO:0030145 manganese ion binding(GO:0030145)
0.1 0.6 GO:0016840 carbon-nitrogen lyase activity(GO:0016840)
0.1 0.5 GO:0008526 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.1 0.4 GO:0004622 lysophospholipase activity(GO:0004622)
0.1 0.3 GO:0004805 trehalose-phosphatase activity(GO:0004805)
0.1 0.5 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.1 0.8 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 0.3 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.3 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.1 0.2 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.1 1.8 GO:0008017 microtubule binding(GO:0008017)
0.1 0.2 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.1 0.3 GO:0001055 RNA polymerase II activity(GO:0001055)
0.1 0.2 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.1 0.3 GO:0055106 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.1 0.3 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 0.4 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.1 0.3 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.7 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.1 0.6 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.1 0.6 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 0.3 GO:0001186 core promoter sequence-specific DNA binding(GO:0001046) transcription factor activity, RNA polymerase I transcription factor recruiting(GO:0001186)
0.1 0.7 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 0.7 GO:0051015 actin filament binding(GO:0051015)
0.1 0.2 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 0.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 0.4 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.1 0.2 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.1 0.2 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.1 0.1 GO:0004738 pyruvate dehydrogenase activity(GO:0004738)
0.1 0.2 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity(GO:0034596) phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.1 0.7 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.8 GO:0050661 NADP binding(GO:0050661)
0.1 0.6 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.1 0.7 GO:0005516 calmodulin binding(GO:0005516)
0.1 0.3 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.1 1.7 GO:0016875 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 1.1 GO:0016836 hydro-lyase activity(GO:0016836)
0.1 0.9 GO:0030515 snoRNA binding(GO:0030515)
0.1 0.2 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.1 0.3 GO:0008312 7S RNA binding(GO:0008312)
0.1 0.2 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.4 GO:0030295 protein kinase activator activity(GO:0030295)
0.0 0.2 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.1 GO:0008443 phosphofructokinase activity(GO:0008443)
0.0 0.4 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.1 GO:0031370 eukaryotic initiation factor 4G binding(GO:0031370)
0.0 0.3 GO:0019205 nucleobase-containing compound kinase activity(GO:0019205)
0.0 0.2 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.1 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.0 0.3 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)
0.0 0.3 GO:0030291 protein serine/threonine kinase inhibitor activity(GO:0030291)
0.0 0.2 GO:0005034 osmosensor activity(GO:0005034)
0.0 0.3 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.2 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.0 1.8 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.1 GO:0015606 spermidine transmembrane transporter activity(GO:0015606)
0.0 0.6 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.1 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 1.3 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.1 GO:0004396 hexokinase activity(GO:0004396)
0.0 0.1 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)
0.0 0.2 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.1 GO:0019206 nucleoside kinase activity(GO:0019206)
0.0 0.1 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.0 0.3 GO:0015631 tubulin binding(GO:0015631)
0.0 0.5 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.1 GO:0008251 adenosine deaminase activity(GO:0004000) tRNA-specific adenosine deaminase activity(GO:0008251)
0.0 0.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.1 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.2 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.9 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 0.2 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.6 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 0.1 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 0.1 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.0 0.8 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.3 GO:0008320 protein transmembrane transporter activity(GO:0008320) macromolecule transmembrane transporter activity(GO:0022884)
0.0 0.4 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.4 GO:0005048 signal sequence binding(GO:0005048)
0.0 0.1 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.0 0.2 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.2 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.0 0.1 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.0 0.3 GO:0008170 N-methyltransferase activity(GO:0008170)
0.0 0.1 GO:0004180 carboxypeptidase activity(GO:0004180)
0.0 0.0 GO:0000403 Y-form DNA binding(GO:0000403)
0.0 0.1 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.6 GO:0008135 translation factor activity, RNA binding(GO:0008135)
0.0 0.2 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.2 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.0 0.1 GO:0008252 nucleotidase activity(GO:0008252)
0.0 0.1 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 0.1 GO:0003724 RNA helicase activity(GO:0003724)
0.0 0.5 GO:0008237 metallopeptidase activity(GO:0008237)
0.0 0.2 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755) cis-trans isomerase activity(GO:0016859)
0.0 0.1 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.0 0.1 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.0 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 0.0 GO:0072341 modified amino acid binding(GO:0072341)
0.0 0.2 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.0 GO:0016882 cyclo-ligase activity(GO:0016882)
0.0 0.0 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.0 0.7 GO:0016791 phosphatase activity(GO:0016791)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.4 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.3 1.3 NABA CORE MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.3 1.0 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.2 0.4 PID ERBB4 PATHWAY ErbB4 signaling events
0.1 0.3 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 0.3 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.1 0.3 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 0.3 PID FGF PATHWAY FGF signaling pathway
0.1 0.1 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.2 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.1 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.1 PID E2F PATHWAY E2F transcription factor network
0.0 0.0 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.3 0.9 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.2 0.5 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.2 1.7 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.2 0.6 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.2 0.8 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.2 3.1 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.2 1.2 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.2 0.3 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.2 0.3 REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT Genes involved in The citric acid (TCA) cycle and respiratory electron transport
0.1 0.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 0.9 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.1 0.7 REACTOME DNA STRAND ELONGATION Genes involved in DNA strand elongation
0.1 0.6 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 0.2 REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.1 0.2 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.5 REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION Genes involved in Post-translational protein modification
0.0 0.2 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.1 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.1 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.2 REACTOME APOPTOSIS Genes involved in Apoptosis
0.0 0.1 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.1 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.0 REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.0 0.2 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase