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Results for LYS14

Z-value: 0.68

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Transcription factors associated with LYS14

Gene Symbol Gene ID Gene Info
LYS14
S000002441 Transcriptional activator involved in regulating lysine biosynthesis

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LYS14YDR034C-0.553.8e-03Click!

Activity profile of LYS14 motif

Sorted Z-values of LYS14 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YFR055W 7.49
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YFR056C 7.39 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YER131W 4.51
RPS26B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YDR098C 3.62
GRX3
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YJR094W-A 3.34
RPL43B
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YDR345C 3.20
HXT3
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YLR154C 2.82
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YPR119W 2.75
CLB2
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YKL096W-A 2.30
CWP2
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YHR094C 2.28
HXT1
Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YER130C 2.26 Hypothetical protein
YLR154W-B 2.24 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YLR154W-C 2.19
TAR1
Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YGL157W 1.97 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YPL250W-A 1.94 Identified by fungal homology and RT-PCR
YMR102C 1.93 Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
YLR154W-A 1.87 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YGL097W 1.84
SRM1
Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
YFR054C 1.78 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR257W 1.73 Putative protein of unknown function
YLR328W 1.69
NMA1
Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways
YDR041W 1.57
RSM10
Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
YDL047W 1.55
SIT4
Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
YGL158W 1.53
RCK1
Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations
YKR092C 1.51
SRP40
Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YNL043C 1.42 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
YJL011C 1.40
RPC17
RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex
YMR290C 1.37
HAS1
ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YNL234W 1.35 Similar to globins and has a functional heme-binding domain; involved in glucose signaling or metabolism; regulated by Rgt1p
YKL051W 1.34
SFK1
Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
YGR138C 1.29
TPO2
Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
YOR376W-A 1.27 Putative protein of unknown function; identified by fungal homology and RT-PCR
YDR344C 1.25 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL148W 1.24
ARO2
Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids
YMR290W-A 1.22 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YGR139W 1.22 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR002W 1.21
YRB1
Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1
YHR007C 1.18
ERG11
Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family
YNR054C 1.18
ESF2
Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
YER117W 1.17
RPL23B
Protein component of the large (60S) ribosomal subunit, identical to Rpl23Ap and has similarity to E. coli L14 and rat L23 ribosomal proteins
YOL136C 1.14
PFK27
6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A
YPR029C 1.11
APL4
Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
YDR040C 1.11
ENA1
P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance
YKR038C 1.11
KAE1
Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex
YER159C 1.10
BUR6
Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha
YER137C 1.09 Putative protein of unknown function
YNL235C 1.03 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SIN4/YNL236W, a subunit of the mediator complex
YKL180W 1.02
RPL17A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Bp and has similarity to E. coli L22 and rat L17 ribosomal proteins; copurifies with the Dam1 complex (aka DASH complex)
YGR157W 1.01
CHO2
Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis
YJR105W 0.99
ADO1
Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
YMR015C 0.97
ERG5
C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
YLR325C 0.96
RPL38
Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein
YMR217W 0.93
GUA1
GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation
YML026C 0.93
RPS18B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Ap and has similarity to E. coli S13 and rat S18 ribosomal proteins
YHL028W 0.92
WSC4
ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3
YDR044W 0.92
HEM13
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YLR109W 0.92
AHP1
Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p
YML077W 0.91
BET5
Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi
YDL192W 0.89
ARF1
ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; functionally interchangeable with Arf2p
YMR082C 0.89 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR089C 0.89
GAR1
Protein component of the H/ACA snoRNP pseudouridylase complex, involved in the modification and cleavage of the 18S pre-rRNA
YKL128C 0.89
PMU1
Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
YGR242W 0.88 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
YBL072C 0.84
RPS8A
Protein component of the small (40S) ribosomal subunit; identical to Rps8Bp and has similarity to rat S8 ribosomal protein
YDL048C 0.83
STP4
Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p
YPR163C 0.83
TIF3
Translation initiation factor eIF-4B, has RNA annealing activity; contains an RNA recognition motif and binds to single-stranded RNA
YER055C 0.83
HIS1
ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
YPL263C 0.82
KEL3
Cytoplasmic protein of unknown function
YML075C 0.81
HMG1
One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae
YKR041W 0.80 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YGR241C 0.80
YAP1802
Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1801p, member of the AP180 protein family
YOR375C 0.80
GDH1
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources
YKR040C 0.80 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W
YIL169C 0.79 Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene
YOR063W 0.78
RPL3
Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus
YKL014C 0.78
URB1
Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit
YOR050C 0.77 Hypothetical protein
YJL024C 0.76
APS3
Small subunit of the clathrin-associated adaptor complex AP-3, which is involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function
YER001W 0.76
MNN1
Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
YPL112C 0.74
PEX25
Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p
YHR092C 0.74
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YEL054C 0.74
RPL12A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Bp; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins
YGR140W 0.74
CBF2
Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo
YOL014W 0.74 Putative protein of unknown function
YDR278C 0.73 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR017W 0.72 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
YNL231C 0.71
PDR16
Phosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p, localizes to lipid particles and microsomes, controls levels of various lipids, may regulate lipid synthesis, homologous to Pdr17p
YOL086C 0.70
ADH1
Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YOR029W 0.69 Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YNL024C 0.69 Putative protein of unknown function with seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL024C is not an essential gene
YGL039W 0.69 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YCR102W-A 0.69 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKR039W 0.68
GAP1
General amino acid permease; localization to the plasma membrane is regulated by nitrogen source
YJR094C 0.67
IME1
Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
YKR026C 0.66
GCN3
Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression
YDR279W 0.65
RNH202
Ribonuclease H2 subunit, required for RNase H2 activity
YDR447C 0.65
RPS17B
Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Ap and has similarity to rat S17 ribosomal protein
YMR119W 0.64
ASI1
Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals
YDR033W 0.63
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YAR071W 0.62
PHO11
One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
YDR215C 0.61 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein
YHR045W 0.61 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
YBR106W 0.61
PHO88
Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations
YFR057W 0.60 Putative protein of unknown function
YOR051C 0.60 Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
YLR262C 0.60
YPT6
GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
YLR108C 0.60 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene
YOL103W 0.59
ITR2
Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively
YIR031C 0.59
DAL7
Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YLR420W 0.58
URA4
Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
YLR301W 0.58 Protein of unknown function that interacts with Sec72p
YMR241W 0.58
YHM2
Mitochondrial DNA-binding protein, component of the mitochondrial nucleoid structure, involved in mtDNA replication and segregation of mitochondrial genomes; member of the mitochondrial carrier protein family
YNR001W-A 0.58 Dubious open reading frame unlikely to encode a functional protein; identified by homology
YGL054C 0.57
ERV14
Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon
YKR093W 0.57
PTR2
Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
YER048C 0.56
CAJ1
Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly
YER124C 0.56
DSE1
Daughter cell-specific protein, may participate in pathways regulating cell wall metabolism; deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall
YCL063W 0.55
VAC17
Protein involved in vacuole inheritance; acts as a vacuole-specific receptor for myosin Myo2p
YJL216C 0.55 Protein of unknown function, similar to alpha-D-glucosidases; transcriptionally activated by both Pdr8p and Yrm1p, along with transporters and other genes involved in the pleiotropic drug resistance (PDR) phenomenon
YDR133C 0.55 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YNL042W-B 0.54 Putative protein of unknown function
YDR240C 0.54
SNU56
Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex
YML088W 0.54
UFO1
F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation
YBR162C 0.54
TOS1
Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C
YBR158W 0.54
AMN1
Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YPR148C 0.53 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YML106W 0.53
URA5
Major orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; minor OPRTase encoded by URA10
YDR399W 0.53
HPT1
Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome
YHR149C 0.53
SKG6
Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
YOR047C 0.53
STD1
Protein involved in control of glucose-regulated gene expression; interacts with protein kinase Snf1p, glucose sensors Snf3p and Rgt2p, and TATA-binding protein Spt15p; acts as a regulator of the transcription factor Rgt1p
YMR049C 0.52
ERB1
Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1
YJL200C 0.52
ACO2
Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
YLR110C 0.52
CCW12
Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor
YLR453C 0.52
RIF2
Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
YER048W-A 0.51
ISD11
Protein required for mitochondrial iron-sulfur cluster biosynthesis
YPL249C-A 0.51
RPL36B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Ap and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA
YGR251W 0.51 Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YCR104W 0.51
PAU3
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YEL027W 0.51
CUP5
Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis
YMR315W 0.50 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR315W is not an essential gene
YPR170W-A 0.50 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry
YGL258W 0.49
VEL1
Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants
YPL111W 0.49
CAR1
Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance
YOR342C 0.49 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YPR060C 0.49
ARO7
Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis
YDR025W 0.49
RPS11A
Protein component of the small (40S) ribosomal subunit; identical to Rps11Bp and has similarity to E. coli S17 and rat S11 ribosomal proteins
YER031C 0.49
YPT31
GTPase of the Ypt/Rab family, very similar to Ypt32p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi
YOR153W 0.48
PDR5
Plasma membrane ATP-binding cassette (ABC) transporter, short-lived multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth
YEL029C 0.47
BUD16
Putative pyridoxal kinase, key enzyme in vitamin B6 metabolism; involved in maintaining levels of pyridoxal 5'-phosphate, the active form of vitamin B6; required for genome integrity; homolog of E. coli PdxK; involved in bud-site selection
YGL037C 0.47
PNC1
Nicotinamidase that converts nicotinamide to nicotinic acid as part of the NAD(+) salvage pathway, required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span
YIL056W 0.46
VHR1
Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations
YIL111W 0.46
COX5B
Subunit Vb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth
YLR185W 0.46
RPL37A
Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Bp and to rat L37 ribosomal protein
YOR130C 0.45
ORT1
Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome
YNL016W 0.45
PUB1
Poly(A)+ RNA-binding protein, abundant mRNP-component protein that binds mRNA and is required for stability of a number of mRNAs; not reported to associate with polyribosomes
YHR180W-A 0.45 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3
YEL040W 0.44
UTR2
Cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; putative chitin transglycosidase; glycosylphosphatidylinositol (GPI)-anchored protein localized to the bud neck; has a role in cell wall maintenance
YGR040W 0.44
KSS1
Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
YNL337W 0.44 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPR170W-B 0.44 Putative protein of unknown function, conserved in fungi; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C
YNR072W 0.43
HXT17
Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose
YPR063C 0.43 ER-localized protein of unknown function
YEL001C 0.43
IRC22
Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
YLR183C 0.43
TOS4
Transcription factor that binds to a number of promoter regions, particularly promoters of some genes involved in pheromone response and cell cycle; potential Cdc28p substrate; expression is induced in G1 by bound SBF
YDL007W 0.43
RPT2
One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
YML111W 0.43
BUL2
Component of the Rsp5p E3-ubiquitin ligase complex, involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions, functional homolog of BUL1
YBR159W 0.42
IFA38
Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides
YMR033W 0.42
ARP9
Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
YPL144W 0.42
POC4
Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
YPL220W 0.42
RPL1A
N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Bp and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal
YNL280C 0.41
ERG24
C-14 sterol reductase, acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions
YDR088C 0.41
SLU7
RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
YFL028C 0.41
CAF16
Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation; putative ABC ATPase; interacts with Ssn2p, Ssn3p, and Ssn8p
YGR240C 0.40
PFK1
Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
YKR027W 0.40
BCH2
Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane
YMR083W 0.40
ADH3
Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YKL110C 0.39
KTI12
Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YGL031C 0.39
RPL24A
Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YNR030W 0.39
ALG12
Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation
YMR194C-A 0.39 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL052C 0.39
ASK1
Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases
YKL097C 0.39 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YPR157W 0.38 Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YER032W 0.38
FIR1
Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate
YOR028C 0.38
CIN5
Basic leucine zipper transcriptional factor of the yAP-1 family that mediates pleiotropic drug resistance and salt tolerance; localizes constitutively to the nucleus
YPL197C 0.38 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B
YBR011C 0.37
IPP1
Cytoplasmic inorganic pyrophosphatase (PPase), catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase
YBR012C 0.36 Dubious open reading frame, unlikely to encode a functional protein; expression induced by iron-regulated transcriptional activator Aft2p
YBR300C 0.36 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene
YOR103C 0.36
OST2
Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
YLR448W 0.36
RPL6B
Protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Ap and to rat L6 ribosomal protein; binds to 5.8S rRNA
YHL018W 0.36 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria and is induced in response to the DNA-damaging agent MMS
YDR331W 0.36
GPI8
ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog
YBR121C 0.35
GRS1
Cytoplasmic and mitochondrial glycyl-tRNA synthase that ligates glycine to the cognate anticodon bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation
YGR293C 0.35 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YGR294W
YOR222W 0.35
ODC2
Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism
YMR011W 0.35
HXT2
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YKL153W 0.35 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant
YCR106W 0.35
RDS1
Zinc cluster transcription factor involved in conferring resistance to cycloheximide
YGL040C 0.34
HEM2
Delta-aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen, the second step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus

Network of associatons between targets according to the STRING database.

First level regulatory network of LYS14

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.5 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.5 3.5 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.5 0.5 GO:0019357 nicotinate nucleotide biosynthetic process(GO:0019357) nicotinate nucleotide salvage(GO:0019358) pyridine nucleotide salvage(GO:0019365) nicotinate nucleotide metabolic process(GO:0046497)
0.4 7.7 GO:0006407 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
0.4 1.6 GO:0000296 spermine transport(GO:0000296)
0.4 2.7 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
0.4 1.1 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.3 1.7 GO:0046417 chorismate metabolic process(GO:0046417)
0.3 1.5 GO:0006177 GMP biosynthetic process(GO:0006177)
0.3 0.8 GO:0045901 positive regulation of translational elongation(GO:0045901)
0.2 0.9 GO:0009240 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490)
0.2 2.6 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.2 1.3 GO:0046501 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.2 0.5 GO:0046495 nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637)
0.2 1.2 GO:0043457 regulation of cellular respiration(GO:0043457)
0.2 1.3 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.2 1.4 GO:0006814 sodium ion transport(GO:0006814)
0.2 1.4 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.2 4.5 GO:0045454 cell redox homeostasis(GO:0045454)
0.2 0.2 GO:0046037 GMP metabolic process(GO:0046037)
0.1 0.1 GO:0042454 ribonucleoside catabolic process(GO:0042454)
0.1 0.1 GO:0032447 protein urmylation(GO:0032447)
0.1 0.6 GO:0019627 urea metabolic process(GO:0019627)
0.1 1.0 GO:0031120 snRNA pseudouridine synthesis(GO:0031120) snRNA modification(GO:0040031)
0.1 0.4 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.1 1.0 GO:0046677 response to antibiotic(GO:0046677)
0.1 0.6 GO:0030497 fatty acid elongation(GO:0030497)
0.1 1.6 GO:0009435 NAD biosynthetic process(GO:0009435)
0.1 0.8 GO:0044205 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.1 0.4 GO:0044209 AMP salvage(GO:0044209)
0.1 0.8 GO:0006491 N-glycan processing(GO:0006491)
0.1 0.3 GO:0071825 lipid tube assembly(GO:0060988) protein-lipid complex assembly(GO:0065005) protein-lipid complex subunit organization(GO:0071825)
0.1 1.1 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.1 1.2 GO:0006116 NADH oxidation(GO:0006116)
0.1 0.2 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 0.3 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
0.1 0.2 GO:0009094 tyrosine biosynthetic process(GO:0006571) L-phenylalanine biosynthetic process(GO:0009094) erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process(GO:1902223)
0.1 2.8 GO:0097384 ergosterol biosynthetic process(GO:0006696) phytosteroid biosynthetic process(GO:0016129) cellular alcohol biosynthetic process(GO:0044108) cellular lipid biosynthetic process(GO:0097384)
0.1 14.6 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 1.0 GO:0006694 steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126)
0.1 0.6 GO:0071406 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
0.1 0.4 GO:0098742 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.1 0.6 GO:0000255 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256) cellular amide catabolic process(GO:0043605)
0.1 0.3 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.1 1.0 GO:0052803 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.1 0.4 GO:1900434 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
0.1 1.5 GO:0010383 cell wall polysaccharide metabolic process(GO:0010383)
0.1 2.3 GO:0006885 regulation of pH(GO:0006885)
0.1 1.1 GO:0007120 axial cellular bud site selection(GO:0007120)
0.1 0.3 GO:0009371 positive regulation of transcription from RNA polymerase II promoter by pheromones(GO:0007329) positive regulation of transcription by pheromones(GO:0009371)
0.1 0.7 GO:0016559 peroxisome fission(GO:0016559)
0.1 0.4 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.1 0.2 GO:0072363 regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361) regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072363)
0.1 0.2 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186) deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
0.1 0.6 GO:0042938 dipeptide transport(GO:0042938)
0.1 0.1 GO:0071902 positive regulation of protein serine/threonine kinase activity(GO:0071902)
0.1 0.4 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.1 0.2 GO:0046855 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
0.1 1.7 GO:0002098 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.1 0.5 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1 0.4 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.1 0.2 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.1 0.7 GO:0051231 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231)
0.1 0.4 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.1 0.5 GO:0010969 regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion(GO:0010969) regulation of signal transduction involved in conjugation with cellular fusion(GO:0060238)
0.1 0.7 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.1 1.0 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.1 0.5 GO:0016233 telomere capping(GO:0016233)
0.1 0.4 GO:0042823 pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823) aldehyde biosynthetic process(GO:0046184)
0.1 0.2 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211) negative regulation of telomere maintenance via telomere lengthening(GO:1904357)
0.1 0.4 GO:0043171 peptide catabolic process(GO:0043171)
0.1 0.1 GO:0031384 regulation of initiation of mating projection growth(GO:0031384)
0.1 0.2 GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)(GO:0000388)
0.1 0.4 GO:0006901 vesicle coating(GO:0006901)
0.1 0.3 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.1 0.2 GO:0006596 polyamine biosynthetic process(GO:0006596)
0.1 0.1 GO:0010695 regulation of spindle pole body separation(GO:0010695)
0.1 0.2 GO:0060277 obsolete negative regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0060277)
0.1 0.2 GO:0007535 donor selection(GO:0007535)
0.1 0.4 GO:0034063 stress granule assembly(GO:0034063)
0.1 0.1 GO:1904668 positive regulation of mitotic nuclear division(GO:0045840) positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101) positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.1 0.2 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
0.1 0.4 GO:0009306 protein secretion(GO:0009306)
0.1 0.9 GO:0006446 regulation of translational initiation(GO:0006446)
0.1 1.6 GO:0051445 regulation of meiotic nuclear division(GO:0040020) regulation of meiotic cell cycle(GO:0051445)
0.0 0.6 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.0 0.3 GO:0046513 ceramide metabolic process(GO:0006672) ceramide biosynthetic process(GO:0046513)
0.0 0.5 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889) regulation of vacuole organization(GO:0044088)
0.0 0.1 GO:0031047 gene silencing involved in chronological cell aging(GO:0010978) gene silencing by RNA(GO:0031047)
0.0 1.1 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.5 GO:0000011 vacuole inheritance(GO:0000011)
0.0 0.4 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.2 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.0 0.1 GO:0006624 vacuolar protein processing(GO:0006624)
0.0 0.4 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.0 1.1 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.0 0.3 GO:0034724 DNA replication-independent nucleosome organization(GO:0034724)
0.0 0.4 GO:0006817 phosphate ion transport(GO:0006817)
0.0 0.3 GO:0034729 histone H3-K79 methylation(GO:0034729)
0.0 0.3 GO:0009099 valine biosynthetic process(GO:0009099)
0.0 0.7 GO:0006378 mRNA polyadenylation(GO:0006378)
0.0 0.5 GO:0006526 arginine biosynthetic process(GO:0006526)
0.0 0.4 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 0.1 GO:1901985 regulation of histone acetylation(GO:0035065) positive regulation of histone acetylation(GO:0035066) regulation of protein acetylation(GO:1901983) positive regulation of protein acetylation(GO:1901985) regulation of peptidyl-lysine acetylation(GO:2000756) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0 0.6 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.5 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.0 0.2 GO:0009097 isoleucine biosynthetic process(GO:0009097)
0.0 0.5 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.3 GO:0030846 termination of RNA polymerase II transcription, poly(A)-coupled(GO:0030846)
0.0 1.2 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 0.1 GO:0070827 chromatin maintenance(GO:0070827)
0.0 0.8 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0 0.3 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.0 0.4 GO:0006353 DNA-templated transcription, termination(GO:0006353)
0.0 0.1 GO:0043902 positive regulation of multi-organism process(GO:0043902)
0.0 0.2 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.0 0.2 GO:0009098 leucine biosynthetic process(GO:0009098)
0.0 0.1 GO:0031590 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.0 0.5 GO:0006448 regulation of translational elongation(GO:0006448)
0.0 0.1 GO:0015883 FAD transport(GO:0015883)
0.0 0.4 GO:0032986 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 0.1 GO:0031335 regulation of sulfur amino acid metabolic process(GO:0031335)
0.0 0.3 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.1 GO:0046831 regulation of mRNA export from nucleus(GO:0010793) regulation of nucleobase-containing compound transport(GO:0032239) regulation of RNA export from nucleus(GO:0046831) regulation of ribonucleoprotein complex localization(GO:2000197)
0.0 1.4 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.1 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.0 0.4 GO:0006513 protein monoubiquitination(GO:0006513)
0.0 0.3 GO:0009304 tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0 0.1 GO:0051125 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315) regulation of actin nucleation(GO:0051125)
0.0 0.1 GO:0015780 nucleotide-sugar transport(GO:0015780)
0.0 0.1 GO:0022615 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0 0.8 GO:0045047 protein targeting to ER(GO:0045047)
0.0 0.5 GO:0071428 rRNA-containing ribonucleoprotein complex export from nucleus(GO:0071428)
0.0 0.2 GO:0015846 polyamine transport(GO:0015846)
0.0 3.6 GO:0006364 rRNA processing(GO:0006364)
0.0 0.1 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 0.6 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.0 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.0 0.1 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.0 0.3 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.0 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.0 0.1 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.1 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.2 GO:0006882 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.0 0.6 GO:0008033 tRNA processing(GO:0008033)
0.0 0.1 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.1 GO:0009373 regulation of transcription by pheromones(GO:0009373) negative regulation of transcription by pheromones(GO:0045996) regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046019) negative regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046020)
0.0 0.0 GO:0034517 ribophagy(GO:0034517)
0.0 0.2 GO:0030011 maintenance of cell polarity(GO:0030011)
0.0 0.1 GO:0009636 response to toxic substance(GO:0009636)
0.0 0.3 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.0 0.1 GO:0034503 protein localization to nucleolar rDNA repeats(GO:0034503)
0.0 0.2 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.0 0.0 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.0 GO:0008299 isoprenoid metabolic process(GO:0006720) isoprenoid biosynthetic process(GO:0008299)
0.0 0.1 GO:0046351 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.0 0.9 GO:0016311 dephosphorylation(GO:0016311)
0.0 0.1 GO:0006415 translational termination(GO:0006415)
0.0 0.3 GO:0006505 GPI anchor metabolic process(GO:0006505)
0.0 0.2 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950) establishment or maintenance of cytoskeleton polarity(GO:0030952)
0.0 0.1 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.1 GO:0006284 base-excision repair(GO:0006284)
0.0 0.3 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.0 GO:0015680 intracellular copper ion transport(GO:0015680)
0.0 0.0 GO:0009071 serine family amino acid catabolic process(GO:0009071)
0.0 0.1 GO:0045116 protein neddylation(GO:0045116)
0.0 0.3 GO:0006184 obsolete GTP catabolic process(GO:0006184)
0.0 0.0 GO:0006857 oligopeptide transport(GO:0006857)
0.0 0.2 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.0 GO:0000101 sulfur amino acid transport(GO:0000101)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.5 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.3 1.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 1.0 GO:0031429 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.2 1.1 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.2 0.8 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.2 0.7 GO:0031518 CBF3 complex(GO:0031518)
0.2 0.5 GO:0070545 PeBoW complex(GO:0070545)
0.2 0.9 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.2 9.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 12.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 0.8 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.1 1.1 GO:0030008 TRAPP complex(GO:0030008)
0.1 0.4 GO:0000131 incipient cellular bud site(GO:0000131)
0.1 0.6 GO:0005771 multivesicular body(GO:0005771)
0.1 0.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 1.7 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 0.3 GO:0031415 NatA complex(GO:0031415)
0.1 0.5 GO:0034044 exomer complex(GO:0034044)
0.1 0.6 GO:0072686 mitotic spindle(GO:0072686)
0.1 0.5 GO:0034456 UTP-C complex(GO:0034456)
0.1 0.4 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.1 0.2 GO:0045298 polar microtubule(GO:0005827) tubulin complex(GO:0045298)
0.1 0.4 GO:0030689 Noc complex(GO:0030689)
0.1 3.0 GO:0030686 90S preribosome(GO:0030686)
0.1 0.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.1 0.8 GO:0030118 clathrin coat(GO:0030118)
0.1 0.7 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 0.8 GO:0022626 cytosolic ribosome(GO:0022626)
0.1 0.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 0.4 GO:0042597 periplasmic space(GO:0042597)
0.1 0.2 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 0.6 GO:0000243 commitment complex(GO:0000243)
0.1 0.2 GO:0070860 RNA polymerase I core factor complex(GO:0070860)
0.1 0.8 GO:0005940 septin ring(GO:0005940)
0.1 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.1 0.6 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 0.5 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.0 0.1 GO:0070823 HDA1 complex(GO:0070823)
0.0 0.8 GO:0016586 RSC complex(GO:0016586)
0.0 0.5 GO:0000782 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0 0.3 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.0 1.6 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 0.1 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.0 0.2 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120) RNA polymerase I upstream activating factor complex(GO:0000500)
0.0 0.3 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.1 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.0 0.2 GO:0044611 nuclear pore inner ring(GO:0044611)
0.0 0.3 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.2 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0 0.4 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.2 GO:0030897 HOPS complex(GO:0030897)
0.0 0.8 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 1.2 GO:0015935 small ribosomal subunit(GO:0015935)
0.0 0.2 GO:0030478 actin cap(GO:0030478)
0.0 2.5 GO:0005815 microtubule organizing center(GO:0005815) spindle pole body(GO:0005816)
0.0 0.1 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 0.2 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.1 GO:0000417 HIR complex(GO:0000417)
0.0 0.1 GO:0034099 luminal surveillance complex(GO:0034099)
0.0 0.2 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.1 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.4 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.2 GO:0005724 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.0 0.2 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.0 GO:0000145 exocyst(GO:0000145)
0.0 0.4 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.2 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.1 GO:0033597 mitotic checkpoint complex(GO:0033597)
0.0 0.1 GO:0033179 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.4 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.3 GO:0034399 nuclear periphery(GO:0034399)
0.0 1.8 GO:0000139 Golgi membrane(GO:0000139)
0.0 3.5 GO:0005933 cellular bud(GO:0005933)
0.0 0.1 GO:0016587 Isw1 complex(GO:0016587)
0.0 0.1 GO:0097344 Rix1 complex(GO:0097344)
0.0 0.8 GO:0005811 lipid particle(GO:0005811)
0.0 0.3 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.2 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.1 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.0 0.5 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.1 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.1 GO:0000792 heterochromatin(GO:0000792)
0.0 0.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 2.6 GO:0005730 nucleolus(GO:0005730)
0.0 0.1 GO:0070772 PAS complex(GO:0070772)
0.0 4.7 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 0.2 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.1 GO:0031414 N-terminal protein acetyltransferase complex(GO:0031414)
0.0 0.1 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 2.0 GO:0005829 cytosol(GO:0005829)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 7.1 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.9 3.5 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.7 2.6 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
0.4 1.2 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.4 1.6 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
0.4 1.1 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.3 1.0 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.3 0.6 GO:0008443 phosphofructokinase activity(GO:0008443)
0.3 0.8 GO:0033592 RNA strand annealing activity(GO:0033592) annealing activity(GO:0097617)
0.3 3.5 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.2 1.0 GO:0019206 nucleoside kinase activity(GO:0019206)
0.2 1.2 GO:0008536 Ran GTPase binding(GO:0008536)
0.2 1.2 GO:0032451 demethylase activity(GO:0032451)
0.2 0.9 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.2 0.6 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.2 1.1 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.2 2.0 GO:0005199 structural constituent of cell wall(GO:0005199)
0.2 1.3 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.2 0.5 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.2 0.8 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.2 0.5 GO:0072341 modified amino acid binding(GO:0072341)
0.2 0.2 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.2 0.5 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.1 0.7 GO:0008525 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.1 1.6 GO:0030276 clathrin binding(GO:0030276)
0.1 0.9 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 1.5 GO:0005516 calmodulin binding(GO:0005516)
0.1 1.7 GO:0070566 adenylyltransferase activity(GO:0070566)
0.1 1.1 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 0.6 GO:0004707 MAP kinase activity(GO:0004707)
0.1 22.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 0.4 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 0.4 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.1 0.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.4 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 0.6 GO:0003993 acid phosphatase activity(GO:0003993)
0.1 1.7 GO:0001056 RNA polymerase III activity(GO:0001056)
0.1 0.3 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.1 0.3 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.1 0.3 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.1 0.4 GO:0001163 RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163)
0.1 0.3 GO:0051219 phosphoprotein binding(GO:0051219)
0.1 0.7 GO:0019237 centromeric DNA binding(GO:0019237)
0.1 1.0 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.1 0.3 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 0.3 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.1 0.8 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.1 0.4 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.1 1.1 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 0.3 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.1 2.5 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.1 0.5 GO:0015081 sodium ion transmembrane transporter activity(GO:0015081)
0.1 0.4 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.1 0.1 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.1 0.8 GO:0016866 intramolecular transferase activity(GO:0016866)
0.1 0.7 GO:0030295 protein kinase activator activity(GO:0030295)
0.1 0.6 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.1 0.2 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 1.3 GO:0019901 protein kinase binding(GO:0019901)
0.1 1.1 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.1 0.3 GO:0004075 biotin carboxylase activity(GO:0004075)
0.1 0.3 GO:0015248 sterol transporter activity(GO:0015248)
0.1 0.4 GO:0019201 nucleotide kinase activity(GO:0019201)
0.1 0.2 GO:0001055 RNA polymerase II activity(GO:0001055)
0.1 0.6 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.1 0.4 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 0.7 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 0.8 GO:0015616 DNA translocase activity(GO:0015616)
0.1 0.2 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.1 0.1 GO:0031370 eukaryotic initiation factor 4G binding(GO:0031370)
0.1 0.7 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.4 GO:0000009 alpha-1,6-mannosyltransferase activity(GO:0000009)
0.0 0.2 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.0 0.5 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 1.2 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.1 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.2 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 1.3 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.4 GO:0005216 ion channel activity(GO:0005216)
0.0 0.5 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.2 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.1 GO:0004000 adenosine deaminase activity(GO:0004000) tRNA-specific adenosine deaminase activity(GO:0008251)
0.0 1.0 GO:0008170 N-methyltransferase activity(GO:0008170)
0.0 0.1 GO:0009922 fatty acid elongase activity(GO:0009922)
0.0 0.2 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.8 GO:0050661 NADP binding(GO:0050661)
0.0 0.4 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.2 GO:0070546 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.0 0.1 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 0.2 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.3 GO:0019842 vitamin binding(GO:0019842)
0.0 2.4 GO:0003924 GTPase activity(GO:0003924)
0.0 0.5 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.2 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.0 1.9 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.1 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.1 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.5 GO:0051087 chaperone binding(GO:0051087)
0.0 0.6 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.4 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.1 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.0 1.0 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.4 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.1 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.6 GO:0008017 microtubule binding(GO:0008017)
0.0 0.2 GO:0019239 deaminase activity(GO:0019239)
0.0 0.6 GO:0051540 iron-sulfur cluster binding(GO:0051536) metal cluster binding(GO:0051540)
0.0 0.1 GO:0004805 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825) trehalose-phosphatase activity(GO:0004805)
0.0 0.1 GO:0004100 chitin synthase activity(GO:0004100)
0.0 0.1 GO:0019203 carbohydrate phosphatase activity(GO:0019203) sugar-phosphatase activity(GO:0050308)
0.0 0.1 GO:0034318 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.0 1.1 GO:0016853 isomerase activity(GO:0016853)
0.0 1.0 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds(GO:0016810)
0.0 0.1 GO:0016504 peptidase activator activity(GO:0016504)
0.0 0.1 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0 0.1 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:0004771 sterol esterase activity(GO:0004771)
0.0 0.2 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.0 0.4 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 0.1 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.0 0.1 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.2 GO:0043495 protein anchor(GO:0043495)
0.0 0.1 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.0 0.0 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.0 0.1 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.5 GO:0016875 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 0.0 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.1 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.1 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.1 GO:0031386 protein tag(GO:0031386)
0.0 0.2 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.0 GO:0000403 Y-form DNA binding(GO:0000403)
0.0 0.1 GO:0051213 dioxygenase activity(GO:0051213)
0.0 0.1 GO:0008762 UDP-N-acetylmuramate dehydrogenase activity(GO:0008762)
0.0 0.4 GO:0008237 metallopeptidase activity(GO:0008237)
0.0 0.1 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 0.1 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.6 GO:0016757 transferase activity, transferring glycosyl groups(GO:0016757)
0.0 0.0 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 0.3 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.1 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.0 0.0 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.0 0.1 GO:0016831 carboxy-lyase activity(GO:0016831)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 0.3 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 0.3 PID SHP2 PATHWAY SHP2 signaling
0.1 0.2 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 0.2 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.1 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.1 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.1 PID PLK1 PATHWAY PLK1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.2 0.5 REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT Genes involved in The citric acid (TCA) cycle and respiratory electron transport
0.2 0.5 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 3.2 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 0.4 REACTOME SIGNALLING TO ERKS Genes involved in Signalling to ERKs
0.1 0.3 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 0.3 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 0.1 REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.0 0.2 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.0 0.5 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.1 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.1 REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.0 0.1 REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION Genes involved in Platelet activation, signaling and aggregation
0.0 0.0 REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION Genes involved in Post-translational protein modification
0.0 0.0 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression