Results for LYS14
Z-value: 0.68
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Transcription factors associated with LYS14
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
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LYS14
|
S000002441 | Transcriptional activator involved in regulating lysine biosynthesis |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YFR055W Show fit | 7.49 |
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner |
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| YFR056C Show fit | 7.39 |
Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W |
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| YER131W Show fit | 4.51 |
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein |
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| YDR098C Show fit | 3.62 |
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage |
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| YJR094W-A Show fit | 3.34 |
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein |
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| YDR345C Show fit | 3.20 |
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions |
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| YLR154C Show fit | 2.82 |
Ribonuclease H2 subunit, required for RNase H2 activity |
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| YPR119W Show fit | 2.75 |
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome |
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| YKL096W-A Show fit | 2.30 |
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored |
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| YHR094C Show fit | 2.28 |
Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting |
Network of associatons between targets according to the STRING database.
First level regulatory network of LYS14
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.6 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.4 | 7.7 | GO:0006407 | rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029) |
| 2.5 | 7.5 | GO:0000098 | sulfur amino acid catabolic process(GO:0000098) |
| 0.2 | 4.5 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 0.0 | 3.6 | GO:0006364 | rRNA processing(GO:0006364) |
| 0.5 | 3.5 | GO:0043137 | DNA replication, removal of RNA primer(GO:0043137) |
| 0.1 | 2.8 | GO:0097384 | ergosterol biosynthetic process(GO:0006696) phytosteroid biosynthetic process(GO:0016129) cellular alcohol biosynthetic process(GO:0044108) cellular lipid biosynthetic process(GO:0097384) |
| 0.4 | 2.7 | GO:0010696 | positive regulation of spindle pole body separation(GO:0010696) |
| 0.2 | 2.6 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.1 | 2.3 | GO:0006885 | regulation of pH(GO:0006885) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.4 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.2 | 9.8 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 4.7 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 1.2 | 3.5 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.0 | 3.5 | GO:0005933 | cellular bud(GO:0005933) |
| 0.1 | 3.0 | GO:0030686 | 90S preribosome(GO:0030686) |
| 0.0 | 2.6 | GO:0005730 | nucleolus(GO:0005730) |
| 0.0 | 2.5 | GO:0005815 | microtubule organizing center(GO:0005815) spindle pole body(GO:0005816) |
| 0.0 | 2.0 | GO:0005829 | cytosol(GO:0005829) |
| 0.0 | 1.8 | GO:0000139 | Golgi membrane(GO:0000139) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 22.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.2 | 7.1 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.9 | 3.5 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 0.3 | 3.5 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.7 | 2.6 | GO:0015146 | pentose transmembrane transporter activity(GO:0015146) |
| 0.1 | 2.5 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.0 | 2.4 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.2 | 2.0 | GO:0005199 | structural constituent of cell wall(GO:0005199) |
| 0.0 | 1.9 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.1 | 1.7 | GO:0070566 | adenylyltransferase activity(GO:0070566) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 0.9 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.1 | 0.3 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 0.3 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.1 | 0.2 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 0.2 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 0.1 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 0.1 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 0.1 | PID PLK1 PATHWAY | PLK1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.2 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.3 | 0.9 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.2 | 0.5 | REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT | Genes involved in The citric acid (TCA) cycle and respiratory electron transport |
| 0.2 | 0.5 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 0.5 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.1 | 0.4 | REACTOME SIGNALLING TO ERKS | Genes involved in Signalling to ERKs |
| 0.1 | 0.3 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.1 | 0.3 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 0.2 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |
| 0.1 | 0.1 | REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 | Genes involved in SCF-beta-TrCP mediated degradation of Emi1 |