Results for LEU3
Z-value: 2.15
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Transcription factors associated with LEU3
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
LEU3
|
S000004443 | Zinc-knuckle transcription factor, repressor and activator |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YFR055W Show fit | 21.69 |
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner |
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| YKL096W-A Show fit | 20.86 |
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored |
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| YFR056C Show fit | 18.97 |
Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W |
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| YER131W Show fit | 18.14 |
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein |
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| YKL120W Show fit | 15.16 |
Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, and thiosulfate; member of the mitochondrial carrier family |
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| YKR092C Show fit | 14.13 |
Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140 |
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| YDR033W Show fit | 13.95 |
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p |
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| YLL045C Show fit | 12.90 |
Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits |
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| YOR376W-A Show fit | 10.92 |
Putative protein of unknown function; identified by fungal homology and RT-PCR |
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| YGL157W Show fit | 10.42 |
Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol) |
Network of associatons between targets according to the STRING database.
First level regulatory network of LEU3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 79.7 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 1.8 | 29.5 | GO:0006407 | rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029) |
| 0.2 | 28.9 | GO:0006364 | rRNA processing(GO:0006364) |
| 1.1 | 27.9 | GO:0006885 | regulation of pH(GO:0006885) |
| 4.5 | 26.7 | GO:0009099 | valine biosynthetic process(GO:0009099) |
| 7.4 | 22.2 | GO:0000098 | sulfur amino acid catabolic process(GO:0000098) |
| 2.0 | 20.3 | GO:0006116 | NADH oxidation(GO:0006116) |
| 3.7 | 18.4 | GO:0009098 | leucine biosynthetic process(GO:0009098) |
| 4.2 | 16.7 | GO:0000296 | spermine transport(GO:0000296) |
| 5.1 | 15.2 | GO:0008272 | sulfate transport(GO:0008272) C4-dicarboxylate transport(GO:0015740) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 64.9 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.7 | 57.7 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.2 | 35.7 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 25.2 | GO:0005730 | nucleolus(GO:0005730) |
| 0.1 | 20.2 | GO:0005933 | cellular bud(GO:0005933) |
| 0.1 | 17.5 | GO:0005886 | plasma membrane(GO:0005886) |
| 0.4 | 17.0 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.3 | 15.2 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.3 | 11.9 | GO:0005576 | extracellular region(GO:0005576) |
| 3.4 | 10.1 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 123.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.9 | 22.7 | GO:0005199 | structural constituent of cell wall(GO:0005199) |
| 0.3 | 19.1 | GO:0003924 | GTPase activity(GO:0003924) |
| 4.2 | 16.7 | GO:0000297 | spermine transmembrane transporter activity(GO:0000297) |
| 2.7 | 16.4 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 2.7 | 16.0 | GO:0004022 | alcohol dehydrogenase (NAD) activity(GO:0004022) |
| 5.1 | 15.2 | GO:0015116 | secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116) |
| 0.1 | 12.4 | GO:0003723 | RNA binding(GO:0003723) |
| 0.3 | 11.3 | GO:0051536 | iron-sulfur cluster binding(GO:0051536) metal cluster binding(GO:0051540) |
| 2.7 | 10.6 | GO:0015146 | pentose transmembrane transporter activity(GO:0015146) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 6.2 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.5 | 1.6 | PID ATM PATHWAY | ATM pathway |
| 0.2 | 1.0 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.2 | 0.9 | PID E2F PATHWAY | E2F transcription factor network |
| 0.2 | 0.8 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 0.2 | 0.7 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.2 | 0.7 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 0.7 | PID ATR PATHWAY | ATR signaling pathway |
| 0.4 | 0.4 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.1 | 0.4 | PID MYC PATHWAY | C-MYC pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 7.2 | REACTOME METABOLISM OF MRNA | Genes involved in Metabolism of mRNA |
| 1.0 | 7.1 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.9 | 6.6 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 2.1 | 6.2 | REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR | Genes involved in Downstream signaling of activated FGFR |
| 2.0 | 5.9 | REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |
| 1.1 | 4.5 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.6 | 4.3 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 0.3 | 2.6 | REACTOME SIGNALING BY GPCR | Genes involved in Signaling by GPCR |
| 0.3 | 1.8 | REACTOME LAGGING STRAND SYNTHESIS | Genes involved in Lagging Strand Synthesis |
| 0.2 | 1.8 | REACTOME G2 M CHECKPOINTS | Genes involved in G2/M Checkpoints |