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Results for INO2

Z-value: 0.83

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Transcription factors associated with INO2

Gene Symbol Gene ID Gene Info
INO2
S000002530 Component of the Ino2p/Ino4p transcription activator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
INO2YDR123C0.714.2e-05Click!

Activity profile of INO2 motif

Sorted Z-values of INO2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YGR157W 10.07
CHO2
Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis
YDR502C 9.29
SAM2
S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YKL182W 8.03
FAS1
Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
YDR497C 7.60
ITR1
Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p
YIL118W 7.56
RHO3
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YCR018C 7.34
SRD1
Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YJL153C 7.28
INO1
Inositol 1-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
YFR055W 7.02
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YFR056C 6.23 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YNL178W 6.18
RPS3
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YJR105W 6.15
ADO1
Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
YAL003W 5.33
EFB1
Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site
YKL218C 4.89
SRY1
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YEL040W 4.28
UTR2
Cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; putative chitin transglycosidase; glycosylphosphatidylinositol (GPI)-anchored protein localized to the bud neck; has a role in cell wall maintenance
YPR170W-B 3.88 Putative protein of unknown function, conserved in fungi; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C
YML026C 3.87
RPS18B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Ap and has similarity to E. coli S13 and rat S18 ribosomal proteins
YBR029C 3.39
CDS1
Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids
YMR123W 3.19
PKR1
V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); overproduction confers resistance to Pichia farinosa killer toxin
YER043C 3.18
SAH1
S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
YPR170W-A 3.13 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry
YPL231W 3.12
FAS2
Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains beta-ketoacyl reductase and beta-ketoacyl synthase activities; phosphorylated
YGL077C 3.08
HNM1
Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol
YPR069C 3.06
SPE3
Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells
YPL037C 3.03
EGD1
Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b
YGR052W 2.96
FMP48
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
YER026C 2.82
CHO1
Phosphatidylserine synthase, functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline
YBR210W 2.81
ERV15
Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p
YLR154C 2.74
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YDR044W 2.73
HEM13
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YHR123W 2.71
EPT1
sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability
YDR033W 2.68
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YGR155W 2.63
CYS4
Cystathionine beta-synthase, catalyzes the synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis
YDR072C 2.55
IPT1
Inositolphosphotransferase 1, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), which is the most abundant sphingolipid in cells, mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media
YCR031C 2.45
RPS14A
Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins
YKL119C 2.40
VPH2
Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER)
YMR290C 2.37
HAS1
ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YLR132C 2.36 Protein of unknown function; green fluorescent protein (GFP)-tagged protein localizes to mitochondria and nucleus; YLR132C is an essential gene
YMR290W-A 2.36 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YER117W 2.33
RPL23B
Protein component of the large (60S) ribosomal subunit, identical to Rpl23Ap and has similarity to E. coli L14 and rat L23 ribosomal proteins
YPR010C 2.30
RPA135
RNA polymerase I subunit A135
YHR208W 2.25
BAT1
Mitochondrial branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase
YOR108W 2.24
LEU9
Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant
YDR344C 2.24 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR050C 2.24 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL141W 2.24
AAH1
Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome
YDR345C 2.23
HXT3
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YER102W 2.21
RPS8B
Protein component of the small (40S) ribosomal subunit; identical to Rps8Ap and has similarity to rat S8 ribosomal protein
YBR030W 2.19 Putative protein of unknown function; predicted protein contains a SET domain (S-adenosyl-L-methionine-binding fold)
YLR109W 2.18
AHP1
Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p
YNR016C 2.18
ACC1
Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids
YMR318C 2.18
ADH6
NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance
YCR034W 2.10
FEN1
Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway
YDR041W 2.09
RSM10
Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
YLR154W-B 2.07 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YNL066W 2.06
SUN4
Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family
YDR050C 2.03
TPI1
Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region
YGR159C 2.03
NSR1
Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
YLR154W-A 1.99 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YJR070C 1.97
LIA1
Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyses hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning
YBR093C 1.95
PHO5
Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
YDR279W 1.94
RNH202
Ribonuclease H2 subunit, required for RNase H2 activity
YGL120C 1.93
PRP43
RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome
YJR071W 1.93 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR212W 1.93
STE4
G protein beta subunit, forms a dimer with Ste18p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste18p to dampen signaling; may recruit Rho1p to the polarized growth site during mating; contains WD40 repeats
YMR246W 1.92
FAA4
Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipids
YMR011W 1.92
HXT2
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YNL169C 1.90
PSD1
Phosphatidylserine decarboxylase of the mitochondrial inner membrane, converts phosphatidylserine to phosphatidylethanolamine
YDR531W 1.90 Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway leading to coenzyme A1
YOL124C 1.87
TRM11
Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
YLR249W 1.86
YEF3
Translational elongation factor 3, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex; contains two ABC cassettes; binds and hydrolyses ATP
YLR286C 1.85
CTS1
Endochitinase, required for cell separation after mitosis; transcriptional activation during late G and early M cell cycle phases is mediated by transcription factor Ace2p
YKL118W 1.84 Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2
YEL053W-A 1.84 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YEL054C
YGR151C 1.81 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C
YNL044W 1.80
YIP3
Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p
YNL069C 1.79
RPL16B
N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Ap, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
YDL226C 1.78
GCS1
ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
YBR158W 1.75
AMN1
Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YHR032W-A 1.74 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YHR032C-A
YDR040C 1.72
ENA1
P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance
YOL013W-A 1.72 Putative protein of unknown function; identified by SAGE
YGR285C 1.72
ZUO1
Cytosolic ribosome-associated chaperone that acts, together with Ssz1p and the Ssb proteins, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p
YHR143W-A 1.70
RPC10
RNA polymerase subunit, found in RNA polymerase complexes I, II, and III
YNL130C 1.67
CPT1
Cholinephosphotransferase, required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription
YOL107W 1.66 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein
YBL085W 1.66
BOI1
Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
YHR181W 1.66
SVP26
Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YJL167W 1.64
ERG20
Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis
YGR234W 1.63
YHB1
Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses
YGR051C 1.62 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene
YLR108C 1.61 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene
YER019C-A 1.59
SBH2
Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
YKR038C 1.59
KAE1
Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex
YOR272W 1.58
YTM1
Constituent of 66S pre-ribosomal particles, required for maturation of the large ribosomal subunit
YOR029W 1.55 Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YOR234C 1.53
RPL33B
Ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Ap and has similarity to rat L35a; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable
YPR036W 1.53
VMA13
Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase
YHL020C 1.52
OPI1
Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance
YPR170C 1.51 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B
YFR054C 1.51 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNR018W 1.50
AIM38
Putative protein of unknown function; non-tagged protein is detected in purified mitochondria; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YLR257W 1.50 Putative protein of unknown function
YFL015W-A 1.49 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR102C 1.48
VPS25
Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
YFL015C 1.47 Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
YDR073W 1.47
SNF11
Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p
YLR011W 1.46
LOT6
FMN-dependent NAD(P)H:quinone reductase that may be involved in quinone detoxification; gene expression increases in cultures shifted to a lower temperature
YKL068W-A 1.46 Putative protein of unknown function; identified by homology to Ashbya gossypii
YGL148W 1.45
ARO2
Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids
YPR171W 1.44
BSP1
Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton
YML088W 1.44
UFO1
F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation
YER137C 1.44 Putative protein of unknown function
YOR108C-A 1.43 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YGR177C 1.42
ATF2
Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important in brewing
YHR025W 1.42
THR1
Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
YJL200C 1.39
ACO2
Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
YLR372W 1.38
SUR4
Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis
YMR199W 1.36
CLN1
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YKL117W 1.36
SBA1
Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins and like p23 can regulate telomerase activity
YBR023C 1.36
CHS3
Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
YPR033C 1.36
HTS1
Cytoplasmic and mitochondrial histidine tRNA synthetase; encoded by a single nuclear gene that specifies two messages; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence
YMR194W 1.36
RPL36A
N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Bp and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA
YER009W 1.36
NTF2
Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
YOR028C 1.36
CIN5
Basic leucine zipper transcriptional factor of the yAP-1 family that mediates pleiotropic drug resistance and salt tolerance; localizes constitutively to the nucleus
YHR136C 1.36
SPL2
Protein with similarity to cyclin-dependent kinase inhibitors, overproduction suppresses a plc1 null mutation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YAR020C 1.34
PAU7
Part of 23-member seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme
YNL256W 1.33
FOL1
Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities
YBR182C-A 1.33 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YGR004W 1.32
PEX31
Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p
YBR143C 1.30
SUP45
Polypeptide release factor involved in translation termination; mutant form acts as a recessive omnipotent suppressor
YNL028W 1.29 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR251W 1.29 Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YCR019W 1.28
MAK32
Protein necessary for structural stability of L-A double-stranded RNA-containing particles
YHR067W 1.27
HTD2
Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology
YGR018C 1.26 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YGR017W
YLR206W 1.26
ENT2
Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
YGR280C 1.26
PXR1
Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain
YDR146C 1.25
SWI5
Transcription factor that activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase
YHR018C 1.24
ARG4
Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway
YHR216W 1.24
IMD2
Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation
YNL234W 1.24 Similar to globins and has a functional heme-binding domain; involved in glucose signaling or metabolism; regulated by Rgt1p
YLR191W 1.22
PEX13
Integral peroxisomal membrane required for the translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p
YPL163C 1.21
SVS1
Cell wall and vacuolar protein, required for wild-type resistance to vanadate
YGL032C 1.21
AGA2
Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds
YPL062W 1.20 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation
YHR180W-A 1.20 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3
YER001W 1.20
MNN1
Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
YJR123W 1.18
RPS5
Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteins
YJL048C 1.16
UBX6
UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline
YML075C 1.16
HMG1
One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae
YER049W 1.16
TPA1
Protein of unknown function; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; has a role in translation termination efficiency, mRNA poly(A) tail length and mRNA stability
YNL029C 1.16
KTR5
Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
YEL001C 1.15
IRC22
Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
YPR157W 1.15 Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YMR009W 1.14
ADI1
Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions
YOR284W 1.14
HUA2
Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
YIR013C 1.12
GAT4
Protein containing GATA family zinc finger motifs
YOR376W-A 1.11 Putative protein of unknown function; identified by fungal homology and RT-PCR
YDL023C 1.11 Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
YLR301W 1.10 Protein of unknown function that interacts with Sec72p
YDL022C-A 1.10 Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene DIA3; identified by fungal homology and RT-PCR
YJR094W-A 1.09
RPL43B
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YOR247W 1.09
SRL1
Mannoprotein that exhibits a tight association with the cell wall, required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants
YOR271C 1.08
FSF1
Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
YMR321C 1.08 Putative protein of unknown function
YMR049C 1.06
ERB1
Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1
YPL256C 1.04
CLN2
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YEL056W 1.03
HAT2
Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing
YEL034C-A 1.03 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; completely overlaps HYP2/YEL034W, a verified gene that encodes eiF-5A
YPR014C 1.03 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene
YOR063W 1.02
RPL3
Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus
YJL198W 1.02
PHO90
Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YDL211C 1.02 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YER107W-A 1.01 Dubious open reading frame unlikely to encode a protein, partially overlaps verified ORF GLE2/YER107C
YIL078W 1.01
THS1
Threonyl-tRNA synthetase, essential cytoplasmic protein
YGR055W 1.01
MUP1
High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
YOL103W 1.00
ITR2
Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively
YER091C 1.00
MET6
Cobalamin-independent methionine synthase, involved in amino acid biosynthesis; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs
YLR416C 0.99 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR321W 0.99
ASP1
Cytosolic L-asparaginase, involved in asparagine catabolism
YOL123W 0.99
HRP1
Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences
YJL188C 0.98
BUD19
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YNR072W 0.96
HXT17
Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose
YDR212W 0.96
TCP1
Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in maintenance of actin cytoskeleton; homolog to Drosophila melanogaster and mouse tailless complex polypeptide
YBR171W 0.95
SEC66
Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YCL059C 0.95
KRR1
Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit
YBR106W 0.94
PHO88
Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations
YML103C 0.94
NUP188
Subunit of the nuclear pore complex (NPC), involved in the structural organization of the complex and of the nuclear envelope, also involved in nuclear envelope permeability, interacts with Pom152p and Nic96p
YJL168C 0.94
SET2
Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
YIL119C 0.94
RPI1
Putative transcriptional regulator; overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation
YDR211W 0.93
GCD6
Catalytic epsilon subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
YER107C 0.93
GLE2
Component of the nuclear pore complex required for polyadenylated RNA export but not for protein import, homologous to S. pombe Rae1p
YOL127W 0.92
RPL25
Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 26S rRNA via a conserved C-terminal motif
YOR273C 0.91
TPO4
Polyamine transport protein, recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily
YDR324C 0.91
UTP4
Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YGR017W 0.91 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
YFR025C 0.91
HIS2
Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
YDL022W 0.91
GPD1
NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p
YLR180W 0.91
SAM1
S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YPL131W 0.90
RPL5
Protein component of the large (60S) ribosomal subunit with similarity to E. coli L18 and rat L5 ribosomal proteins; binds 5S rRNA and is required for 60S subunit assembly

Network of associatons between targets according to the STRING database.

First level regulatory network of INO2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 10.2 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
2.4 7.1 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
1.9 7.6 GO:0090338 regulation of formin-nucleated actin cable assembly(GO:0090337) positive regulation of formin-nucleated actin cable assembly(GO:0090338)
1.8 5.5 GO:0044209 AMP salvage(GO:0044209)
1.8 3.6 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
1.5 8.9 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
1.4 5.6 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
1.3 11.9 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
1.3 2.5 GO:0046083 adenine metabolic process(GO:0046083)
1.3 7.6 GO:0006021 inositol biosynthetic process(GO:0006021)
1.2 4.8 GO:0035337 fatty-acyl-CoA metabolic process(GO:0035337)
1.1 7.6 GO:0015791 polyol transport(GO:0015791)
1.0 2.9 GO:0008216 spermidine metabolic process(GO:0008216)
0.9 3.5 GO:0030497 fatty acid elongation(GO:0030497)
0.7 3.7 GO:0070814 hydrogen sulfide metabolic process(GO:0070813) hydrogen sulfide biosynthetic process(GO:0070814)
0.7 2.1 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
0.7 5.0 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.7 12.4 GO:0051029 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
0.7 5.5 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.7 0.7 GO:0035952 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
0.7 2.0 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.7 3.3 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.6 4.5 GO:0009098 leucine biosynthetic process(GO:0009098)
0.6 1.2 GO:0046490 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490)
0.5 13.1 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.5 3.2 GO:0072337 modified amino acid transport(GO:0072337)
0.5 2.0 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.5 1.5 GO:0042992 negative regulation of transcription factor import into nucleus(GO:0042992)
0.5 7.7 GO:0006037 cell wall chitin metabolic process(GO:0006037)
0.5 0.9 GO:0010793 regulation of mRNA export from nucleus(GO:0010793) regulation of nucleobase-containing compound transport(GO:0032239) regulation of RNA export from nucleus(GO:0046831) regulation of ribonucleoprotein complex localization(GO:2000197)
0.5 1.9 GO:0006032 aminoglycan catabolic process(GO:0006026) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.4 6.2 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.4 0.9 GO:0000101 sulfur amino acid transport(GO:0000101)
0.4 2.9 GO:0046501 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.4 1.2 GO:0045896 regulation of transcription during mitosis(GO:0045896)
0.4 1.6 GO:0098610 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.4 1.2 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037) actin filament reorganization(GO:0090527)
0.4 1.9 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509) amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
0.4 3.1 GO:2000278 regulation of telomere maintenance via telomerase(GO:0032210) regulation of telomere maintenance via telomere lengthening(GO:1904356) regulation of DNA biosynthetic process(GO:2000278)
0.4 1.5 GO:0000296 spermine transport(GO:0000296)
0.4 1.5 GO:0009423 chorismate biosynthetic process(GO:0009423)
0.4 1.8 GO:0000390 spliceosomal complex disassembly(GO:0000390)
0.3 4.3 GO:0006415 translational termination(GO:0006415)
0.3 2.0 GO:0046037 GMP metabolic process(GO:0046037)
0.3 1.6 GO:0045338 terpenoid metabolic process(GO:0006721) terpenoid biosynthetic process(GO:0016114) farnesyl diphosphate biosynthetic process(GO:0045337) farnesyl diphosphate metabolic process(GO:0045338)
0.3 1.8 GO:0071406 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
0.3 0.6 GO:0000751 mitotic cell cycle arrest in response to pheromone(GO:0000751) mitotic cell cycle arrest(GO:0071850)
0.3 4.1 GO:0006972 hyperosmotic response(GO:0006972)
0.3 0.9 GO:0061647 histone H3 acetylation(GO:0043966) histone H3-K9 acetylation(GO:0043970) histone H3-K14 acetylation(GO:0044154) histone H3-K9 modification(GO:0061647)
0.3 1.7 GO:0009088 threonine biosynthetic process(GO:0009088)
0.3 2.8 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
0.3 1.1 GO:0006528 asparagine metabolic process(GO:0006528)
0.3 12.0 GO:0006414 translational elongation(GO:0006414)
0.2 4.4 GO:0009636 response to toxic substance(GO:0009636)
0.2 1.2 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.2 1.2 GO:0006491 N-glycan processing(GO:0006491)
0.2 3.1 GO:0007120 axial cellular bud site selection(GO:0007120)
0.2 0.2 GO:0046855 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
0.2 2.1 GO:0045014 negative regulation of transcription from RNA polymerase II promoter by glucose(GO:0000433) negative regulation of transcription by glucose(GO:0045014)
0.2 2.7 GO:0090529 barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529)
0.2 3.7 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.2 1.2 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.2 1.0 GO:0046656 folic acid metabolic process(GO:0046655) folic acid biosynthetic process(GO:0046656)
0.2 1.8 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.2 0.6 GO:0071044 histone mRNA metabolic process(GO:0008334) histone mRNA catabolic process(GO:0071044)
0.2 0.5 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186) deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
0.2 2.4 GO:0006555 methionine metabolic process(GO:0006555)
0.2 0.5 GO:0010674 negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010674)
0.2 0.5 GO:0015680 intracellular copper ion transport(GO:0015680)
0.2 1.3 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.2 1.7 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.2 1.3 GO:0000105 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.2 0.8 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.2 1.2 GO:0006591 ornithine metabolic process(GO:0006591)
0.1 2.6 GO:0042797 tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.1 4.5 GO:0006505 GPI anchor metabolic process(GO:0006505)
0.1 0.4 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.1 1.5 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.1 0.4 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.1 0.3 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.1 4.0 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 0.5 GO:0018279 peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279)
0.1 2.4 GO:0030488 tRNA methylation(GO:0030488)
0.1 0.4 GO:0051176 regulation of vitamin metabolic process(GO:0030656) positive regulation of vitamin metabolic process(GO:0046136) positive regulation of sulfur metabolic process(GO:0051176) regulation of thiamine biosynthetic process(GO:0070623) positive regulation of thiamine biosynthetic process(GO:0090180)
0.1 0.4 GO:0046495 nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637)
0.1 0.4 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.1 0.4 GO:0060188 regulation of protein desumoylation(GO:0060188)
0.1 3.4 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.1 0.4 GO:0019673 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
0.1 0.6 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.1 0.7 GO:0070096 mitochondrial outer membrane translocase complex assembly(GO:0070096)
0.1 1.1 GO:0006272 leading strand elongation(GO:0006272)
0.1 0.9 GO:0034501 protein localization to kinetochore(GO:0034501)
0.1 0.5 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.1 0.8 GO:0030846 termination of RNA polymerase II transcription, poly(A)-coupled(GO:0030846)
0.1 0.2 GO:0009847 spore germination(GO:0009847)
0.1 1.1 GO:0007121 bipolar cellular bud site selection(GO:0007121)
0.1 0.1 GO:0033239 negative regulation of cellular amine metabolic process(GO:0033239)
0.1 0.4 GO:0042255 ribosome assembly(GO:0042255)
0.1 0.3 GO:0002188 translation reinitiation(GO:0002188)
0.1 1.4 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.1 0.2 GO:0048211 Golgi vesicle docking(GO:0048211)
0.1 9.8 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 1.0 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.1 1.5 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.1 1.2 GO:0051666 actin cortical patch localization(GO:0051666)
0.1 16.3 GO:0006364 rRNA processing(GO:0006364)
0.1 0.2 GO:0006566 threonine metabolic process(GO:0006566)
0.1 1.2 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.1 0.3 GO:0033262 regulation of nuclear cell cycle DNA replication(GO:0033262)
0.1 1.0 GO:0000147 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.1 1.3 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968) cellular response to unfolded protein(GO:0034620)
0.1 0.9 GO:0006446 regulation of translational initiation(GO:0006446)
0.1 0.2 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.1 0.8 GO:0017148 negative regulation of translation(GO:0017148) negative regulation of cellular amide metabolic process(GO:0034249)
0.1 0.7 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.1 1.4 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.1 0.4 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.1 0.5 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779) heme biosynthetic process(GO:0006783) tetrapyrrole biosynthetic process(GO:0033014)
0.1 1.3 GO:0010038 response to metal ion(GO:0010038)
0.1 0.3 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.1 0.4 GO:0046351 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.1 0.4 GO:0009082 isoleucine metabolic process(GO:0006549) branched-chain amino acid biosynthetic process(GO:0009082)
0.1 0.2 GO:0015693 magnesium ion transport(GO:0015693)
0.1 0.4 GO:0000743 nuclear migration involved in conjugation with cellular fusion(GO:0000743)
0.1 2.0 GO:0045047 protein targeting to ER(GO:0045047)
0.1 0.3 GO:0035437 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.1 0.3 GO:0034354 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.1 0.2 GO:0046473 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.1 1.5 GO:0033753 ribosomal subunit export from nucleus(GO:0000054) ribosome localization(GO:0033750) establishment of ribosome localization(GO:0033753) rRNA-containing ribonucleoprotein complex export from nucleus(GO:0071428)
0.1 1.1 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 0.1 GO:0071035 snRNA catabolic process(GO:0016076) snoRNA catabolic process(GO:0016077) polyadenylation-dependent ncRNA catabolic process(GO:0043634) nuclear ncRNA surveillance(GO:0071029) nuclear mRNA surveillance of mRNA 3'-end processing(GO:0071031) nuclear polyadenylation-dependent rRNA catabolic process(GO:0071035) nuclear polyadenylation-dependent snoRNA catabolic process(GO:0071036) nuclear polyadenylation-dependent snRNA catabolic process(GO:0071037) nuclear polyadenylation-dependent ncRNA catabolic process(GO:0071046)
0.1 0.5 GO:0030011 maintenance of cell polarity(GO:0030011)
0.1 0.5 GO:0000921 septin ring assembly(GO:0000921)
0.1 0.8 GO:0031498 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.1 0.3 GO:0055069 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.1 0.2 GO:0060277 obsolete negative regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0060277)
0.1 0.2 GO:0000957 mitochondrial RNA catabolic process(GO:0000957)
0.1 0.7 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.1 1.6 GO:1902593 protein import into nucleus(GO:0006606) nuclear import(GO:0051170) single-organism nuclear import(GO:1902593)
0.0 0.3 GO:0006855 drug transmembrane transport(GO:0006855)
0.0 0.1 GO:0071456 cellular response to hypoxia(GO:0071456)
0.0 1.9 GO:0006400 tRNA modification(GO:0006400)
0.0 0.7 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.0 0.4 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.4 GO:0000742 karyogamy involved in conjugation with cellular fusion(GO:0000742)
0.0 0.1 GO:0006458 'de novo' protein folding(GO:0006458)
0.0 0.1 GO:0016320 endoplasmic reticulum membrane fusion(GO:0016320)
0.0 0.9 GO:0042254 ribosome biogenesis(GO:0042254)
0.0 0.2 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.2 GO:0046219 tryptophan biosynthetic process(GO:0000162) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
0.0 0.2 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.2 GO:0034503 protein localization to nucleolar rDNA repeats(GO:0034503)
0.0 0.2 GO:0015883 FAD transport(GO:0015883)
0.0 0.3 GO:0006797 polyphosphate metabolic process(GO:0006797)
0.0 0.5 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.2 GO:0043457 regulation of cellular respiration(GO:0043457)
0.0 2.5 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.9 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.1 GO:0097549 heterochromatin organization involved in chromatin silencing(GO:0070868) chromatin organization involved in negative regulation of transcription(GO:0097549)
0.0 0.1 GO:0009371 positive regulation of transcription from RNA polymerase II promoter by pheromones(GO:0007329) positive regulation of transcription by pheromones(GO:0009371)
0.0 0.1 GO:0009411 response to UV(GO:0009411)
0.0 0.6 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.0 0.2 GO:0006771 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.0 0.1 GO:0051446 positive regulation of meiotic nuclear division(GO:0045836) positive regulation of meiotic cell cycle(GO:0051446)
0.0 0.2 GO:0009303 rRNA transcription(GO:0009303)
0.0 0.3 GO:0008298 intracellular mRNA localization(GO:0008298)
0.0 0.1 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.2 GO:0009395 phospholipid catabolic process(GO:0009395)
0.0 0.3 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.0 0.1 GO:0031047 gene silencing involved in chronological cell aging(GO:0010978) gene silencing by RNA(GO:0031047)
0.0 0.2 GO:0007009 plasma membrane organization(GO:0007009)
0.0 0.2 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.1 GO:0048255 RNA stabilization(GO:0043489) mRNA stabilization(GO:0048255)
0.0 0.0 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.1 GO:0006517 protein deglycosylation(GO:0006517)
0.0 0.8 GO:0006333 chromatin assembly or disassembly(GO:0006333)
0.0 0.1 GO:0071072 negative regulation of phospholipid biosynthetic process(GO:0071072) negative regulation of phospholipid metabolic process(GO:1903726)
0.0 0.1 GO:0000376 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.0 0.4 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.0 0.1 GO:0015740 C4-dicarboxylate transport(GO:0015740)
0.0 0.3 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.1 GO:0007323 peptide pheromone maturation(GO:0007323)
0.0 0.1 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.0 0.1 GO:0019401 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.0 0.3 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.2 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.2 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.2 GO:0043094 cellular metabolic compound salvage(GO:0043094)
0.0 0.1 GO:0055070 cellular copper ion homeostasis(GO:0006878) copper ion homeostasis(GO:0055070)
0.0 0.2 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.0 0.1 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.0 0.1 GO:0000707 meiotic DNA recombinase assembly(GO:0000707) DNA recombinase assembly(GO:0000730)
0.0 0.1 GO:0016574 histone ubiquitination(GO:0016574)
0.0 0.1 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0 0.0 GO:0009435 NAD biosynthetic process(GO:0009435)
0.0 0.1 GO:0051320 mitotic S phase(GO:0000084) S phase(GO:0051320)
0.0 1.0 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.0 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0 0.1 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889) regulation of vacuole organization(GO:0044088)
0.0 0.1 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.7 GO:0032299 ribonuclease H2 complex(GO:0032299)
1.0 5.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
1.0 3.0 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
1.0 2.9 GO:0070545 PeBoW complex(GO:0070545)
0.7 2.2 GO:0000814 ESCRT II complex(GO:0000814)
0.6 6.8 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.6 5.1 GO:0000144 cellular bud neck septin ring(GO:0000144)
0.5 1.6 GO:0071261 Ssh1 translocon complex(GO:0071261)
0.5 1.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.4 1.8 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.4 5.1 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.4 2.1 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.3 1.6 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.3 0.8 GO:0097344 Rix1 complex(GO:0097344)
0.3 0.5 GO:0030008 TRAPP complex(GO:0030008)
0.3 10.0 GO:0005811 lipid particle(GO:0005811)
0.3 0.5 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.3 1.8 GO:0033180 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.2 1.9 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.2 0.9 GO:0031207 endoplasmic reticulum Sec complex(GO:0031205) Sec62/Sec63 complex(GO:0031207)
0.2 0.9 GO:0044611 nuclear pore inner ring(GO:0044611)
0.2 0.7 GO:0030689 Noc complex(GO:0030689)
0.2 13.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 7.5 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.2 1.1 GO:0034518 RNA cap binding complex(GO:0034518)
0.2 0.6 GO:0031415 NatA complex(GO:0031415)
0.2 16.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 0.9 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.2 0.6 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.2 0.7 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.2 2.2 GO:0022626 cytosolic ribosome(GO:0022626)
0.2 0.6 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.2 0.8 GO:0031389 DNA replication factor C complex(GO:0005663) Rad17 RFC-like complex(GO:0031389) Elg1 RFC-like complex(GO:0031391)
0.2 0.6 GO:0030892 mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990)
0.1 0.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.4 GO:0033186 CAF-1 complex(GO:0033186)
0.1 0.9 GO:0034455 t-UTP complex(GO:0034455)
0.1 0.4 GO:0005827 polar microtubule(GO:0005827) tubulin complex(GO:0045298)
0.1 1.0 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 0.8 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.1 2.6 GO:0030133 transport vesicle(GO:0030133)
0.1 4.7 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 1.3 GO:0016514 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.1 2.7 GO:0005844 polysome(GO:0005844)
0.1 0.5 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 0.5 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.1 1.2 GO:0034399 nuclear periphery(GO:0034399)
0.1 0.4 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.1 0.9 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 1.9 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.1 0.7 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 1.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 0.6 GO:0032432 actin filament bundle(GO:0032432)
0.1 0.9 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.1 0.5 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.1 1.0 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.1 1.0 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 26.2 GO:0005783 endoplasmic reticulum(GO:0005783)
0.1 0.2 GO:0005825 half bridge of spindle pole body(GO:0005825)
0.1 0.2 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 0.2 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.1 2.6 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 0.2 GO:0031518 CBF3 complex(GO:0031518)
0.1 0.6 GO:0042597 periplasmic space(GO:0042597)
0.1 0.3 GO:0070209 ASTRA complex(GO:0070209)
0.1 0.2 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 15.2 GO:0005829 cytosol(GO:0005829)
0.1 0.2 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1 0.1 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)
0.1 0.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 0.5 GO:0017119 Golgi transport complex(GO:0017119)
0.1 5.4 GO:0043332 mating projection tip(GO:0043332)
0.1 0.4 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 0.6 GO:0042729 DASH complex(GO:0042729)
0.1 2.0 GO:0015935 small ribosomal subunit(GO:0015935)
0.1 1.3 GO:0032040 small-subunit processome(GO:0032040)
0.1 0.4 GO:0000346 transcription export complex(GO:0000346)
0.1 0.1 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.1 0.2 GO:0000811 GINS complex(GO:0000811)
0.1 0.3 GO:0005871 kinesin complex(GO:0005871)
0.1 0.2 GO:0030869 RENT complex(GO:0030869)
0.1 1.0 GO:0000131 incipient cellular bud site(GO:0000131)
0.0 0.2 GO:0033597 mitotic checkpoint complex(GO:0033597)
0.0 0.3 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.2 GO:0000938 GARP complex(GO:0000938)
0.0 0.5 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.3 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.1 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.2 GO:0000439 core TFIIH complex(GO:0000439)
0.0 0.2 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.5 GO:0016586 RSC complex(GO:0016586)
0.0 2.0 GO:0005635 nuclear envelope(GO:0005635)
0.0 3.8 GO:0005730 nucleolus(GO:0005730)
0.0 0.4 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.1 GO:0070823 HDA1 complex(GO:0070823)
0.0 0.5 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 0.1 GO:0030907 MBF transcription complex(GO:0030907)
0.0 0.2 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.1 GO:0042555 MCM complex(GO:0042555)
0.0 0.1 GO:0031414 N-terminal protein acetyltransferase complex(GO:0031414)
0.0 0.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.3 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.1 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967) pyruvate dehydrogenase complex(GO:0045254)
0.0 0.2 GO:0000502 proteasome complex(GO:0000502)
0.0 0.1 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.1 GO:0000243 commitment complex(GO:0000243)
0.0 0.3 GO:0005741 mitochondrial outer membrane(GO:0005741)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 8.6 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
2.4 7.3 GO:0016872 intramolecular lyase activity(GO:0016872)
2.0 8.0 GO:0016417 S-acyltransferase activity(GO:0016417)
1.5 6.1 GO:0019206 nucleoside kinase activity(GO:0019206)
1.4 7.1 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
1.2 4.9 GO:0016854 ammonia-lyase activity(GO:0016841) racemase and epimerase activity(GO:0016854)
1.2 4.7 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
1.2 3.5 GO:0009922 fatty acid elongase activity(GO:0009922)
1.1 6.5 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
1.0 6.3 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
1.0 3.0 GO:0008897 holo-[acyl-carrier-protein] synthase activity(GO:0008897)
0.9 2.7 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.8 3.4 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)
0.7 0.7 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.7 2.7 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.7 2.6 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.6 2.6 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
0.6 1.2 GO:0016840 carbon-nitrogen lyase activity(GO:0016840)
0.6 1.9 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.6 1.7 GO:0019202 amino acid kinase activity(GO:0019202)
0.5 2.2 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
0.5 1.5 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.5 1.5 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.5 7.0 GO:0003746 translation elongation factor activity(GO:0003746)
0.5 1.4 GO:0051219 phosphoprotein binding(GO:0051219)
0.5 10.6 GO:0008170 N-methyltransferase activity(GO:0008170)
0.5 16.4 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.5 1.4 GO:0004100 chitin synthase activity(GO:0004100)
0.4 1.3 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.4 1.2 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.4 1.9 GO:0004026 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.4 4.2 GO:0051213 dioxygenase activity(GO:0051213)
0.4 1.5 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
0.4 5.1 GO:0001054 RNA polymerase I activity(GO:0001054)
0.3 2.0 GO:0003993 acid phosphatase activity(GO:0003993)
0.3 1.0 GO:0043812 phosphatidylinositol phosphate 4-phosphatase activity(GO:0034596) phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.3 1.3 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.3 2.2 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.3 0.9 GO:0008097 5S rRNA binding(GO:0008097)
0.3 1.5 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
0.3 2.3 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.3 1.4 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.3 0.8 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.3 1.6 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.3 1.4 GO:0008536 Ran GTPase binding(GO:0008536)
0.3 0.8 GO:0031370 eukaryotic initiation factor 4G binding(GO:0031370)
0.3 0.8 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.3 5.7 GO:0016836 hydro-lyase activity(GO:0016836)
0.3 1.0 GO:0004622 lysophospholipase activity(GO:0004622)
0.2 1.0 GO:0008172 S-methyltransferase activity(GO:0008172)
0.2 0.7 GO:0033592 RNA strand annealing activity(GO:0033592) annealing activity(GO:0097617)
0.2 2.2 GO:0019239 deaminase activity(GO:0019239)
0.2 8.6 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.2 0.8 GO:0015038 glutathione-disulfide reductase activity(GO:0004362) peptide disulfide oxidoreductase activity(GO:0015037) glutathione disulfide oxidoreductase activity(GO:0015038)
0.2 0.4 GO:0001181 transcription factor activity, core RNA polymerase I binding(GO:0001181)
0.2 1.4 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.2 1.9 GO:0005216 ion channel activity(GO:0005216)
0.2 0.6 GO:0000339 RNA cap binding(GO:0000339)
0.2 1.7 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.2 1.6 GO:0004497 monooxygenase activity(GO:0004497)
0.2 0.6 GO:0036002 pre-mRNA binding(GO:0036002)
0.2 6.0 GO:0019843 rRNA binding(GO:0019843)
0.1 0.7 GO:0070546 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.1 0.4 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 1.6 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 1.7 GO:0030276 clathrin binding(GO:0030276)
0.1 1.4 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 0.3 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 0.4 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.1 1.0 GO:0019201 nucleotide kinase activity(GO:0019201)
0.1 5.5 GO:0030674 protein binding, bridging(GO:0030674)
0.1 0.7 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.1 23.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 0.8 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 0.8 GO:0070300 phosphatidic acid binding(GO:0070300)
0.1 0.6 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 3.7 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.1 0.4 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825)
0.1 0.4 GO:0048038 quinone binding(GO:0048038)
0.1 0.4 GO:0070568 guanylyltransferase activity(GO:0070568)
0.1 1.7 GO:0042803 protein homodimerization activity(GO:0042803)
0.1 0.5 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 3.9 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 2.1 GO:0051087 chaperone binding(GO:0051087)
0.1 0.5 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.1 0.5 GO:0008312 7S RNA binding(GO:0008312)
0.1 0.4 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.1 0.5 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 0.8 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 1.1 GO:0005048 signal sequence binding(GO:0005048)
0.1 0.9 GO:0001056 RNA polymerase III activity(GO:0001056)
0.1 0.7 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 0.4 GO:0001132 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132)
0.1 0.9 GO:0001671 ATPase activator activity(GO:0001671)
0.1 0.7 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.1 0.4 GO:0004707 MAP kinase activity(GO:0004707)
0.1 0.4 GO:0042123 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.1 0.4 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.1 2.4 GO:0003779 actin binding(GO:0003779)
0.1 0.2 GO:0004602 glutathione peroxidase activity(GO:0004602) phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.1 2.1 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 0.8 GO:0005199 structural constituent of cell wall(GO:0005199)
0.1 0.4 GO:0019211 phosphatase activator activity(GO:0019211)
0.1 3.7 GO:0003924 GTPase activity(GO:0003924)
0.1 0.2 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.1 3.7 GO:0051082 unfolded protein binding(GO:0051082)
0.1 0.5 GO:0032934 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.1 0.2 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 0.3 GO:0001139 transcription factor activity, core RNA polymerase II recruiting(GO:0001139)
0.1 0.3 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.1 0.5 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 0.6 GO:0046906 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.1 0.2 GO:0008310 single-stranded DNA exodeoxyribonuclease activity(GO:0008297) single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.1 2.0 GO:0000030 mannosyltransferase activity(GO:0000030)
0.1 0.3 GO:0008443 phosphofructokinase activity(GO:0008443)
0.1 0.3 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.1 0.2 GO:0043139 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 0.3 GO:0019237 centromeric DNA binding(GO:0019237)
0.0 0.4 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.2 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.0 0.7 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.6 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 1.0 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 0.5 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.4 GO:0019209 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.0 0.1 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 0.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.2 GO:0008525 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.0 0.2 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.0 1.0 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.1 GO:0019776 Atg8 ligase activity(GO:0019776)
0.0 1.2 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.3 GO:0019904 protein domain specific binding(GO:0019904)
0.0 0.1 GO:0016531 copper chaperone activity(GO:0016531)
0.0 0.6 GO:0005506 iron ion binding(GO:0005506)
0.0 1.6 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.3 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.1 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.0 0.2 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.0 0.2 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.4 GO:0016769 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.0 0.4 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.2 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.6 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.2 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.6 GO:0019887 protein kinase regulator activity(GO:0019887)
0.0 0.1 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.1 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.0 GO:0004375 glycine dehydrogenase (decarboxylating) activity(GO:0004375) oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor(GO:0016642)
0.0 1.0 GO:0016791 phosphatase activity(GO:0016791)
0.0 0.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.1 GO:0042277 peptide binding(GO:0042277)
0.0 0.1 GO:0004738 pyruvate dehydrogenase activity(GO:0004738)
0.0 0.6 GO:0016853 isomerase activity(GO:0016853)
0.0 0.7 GO:0004871 signal transducer activity(GO:0004871)
0.0 0.1 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.0 0.1 GO:0001055 RNA polymerase II activity(GO:0001055)
0.0 1.5 GO:0003682 chromatin binding(GO:0003682)
0.0 0.2 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.2 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.1 GO:0003724 RNA helicase activity(GO:0003724)
0.0 0.1 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 0.1 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.0 0.1 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0 0.1 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.1 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.0 0.1 GO:0004177 aminopeptidase activity(GO:0004177)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 PID CDC42 PATHWAY CDC42 signaling events
0.5 0.5 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.1 0.4 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 0.6 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 0.2 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 0.3 PID E2F PATHWAY E2F transcription factor network
0.1 0.4 NABA CORE MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.1 0.3 PID LKB1 PATHWAY LKB1 signaling events
0.1 0.8 PID ATR PATHWAY ATR signaling pathway
0.1 0.2 PID ATM PATHWAY ATM pathway
0.1 0.2 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.2 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.1 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 0.1 PID PDGFRB PATHWAY PDGFR-beta signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 7.0 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.9 7.4 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.6 2.5 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.6 1.2 REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE Genes involved in NFkB and MAP kinases activation mediated by TLR4 signaling repertoire
0.6 1.8 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.5 1.4 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.4 2.2 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.4 1.1 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.3 1.4 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.3 1.7 REACTOME LAGGING STRAND SYNTHESIS Genes involved in Lagging Strand Synthesis
0.2 3.9 REACTOME INFLUENZA LIFE CYCLE Genes involved in Influenza Life Cycle
0.2 1.2 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1 0.7 REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION Genes involved in Platelet activation, signaling and aggregation
0.1 0.2 REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.1 0.3 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 0.1 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.3 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.1 REACTOME AXON GUIDANCE Genes involved in Axon guidance
0.0 0.6 REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS Genes involved in Metabolism of lipids and lipoproteins
0.0 0.2 REACTOME TRANSLATION Genes involved in Translation
0.0 0.2 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.1 REACTOME DNA STRAND ELONGATION Genes involved in DNA strand elongation
0.0 0.2 REACTOME TRANSCRIPTION Genes involved in Transcription