Results for HSF1
Z-value: 2.17
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Transcription factors associated with HSF1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
HSF1
|
S000003041 | Trimeric heat shock transcription factor |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YBR117C Show fit | 23.20 |
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids |
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| YGR142W Show fit | 20.55 |
v-SNARE binding protein that facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase |
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| YBR072W Show fit | 18.07 |
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells |
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| YDR342C Show fit | 13.84 |
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels |
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| YER103W Show fit | 13.81 |
Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation |
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| YPL250C Show fit | 13.49 |
Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate |
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| YFL051C Show fit | 12.61 |
Putative protein of unknown function; YFL051C is not an essential gene |
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| YBL075C Show fit | 11.77 |
ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm |
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| YAR050W Show fit | 11.01 |
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p |
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| YJL045W Show fit | 10.64 |
Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner |
Network of associatons between targets according to the STRING database.
First level regulatory network of HSF1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.8 | 34.5 | GO:0006616 | SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616) |
| 1.9 | 28.6 | GO:0006098 | pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682) |
| 1.2 | 28.4 | GO:0008645 | hexose transport(GO:0008645) monosaccharide transport(GO:0015749) |
| 1.9 | 24.5 | GO:0042026 | protein refolding(GO:0042026) |
| 3.6 | 21.7 | GO:0000128 | flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501) |
| 0.7 | 19.5 | GO:0006885 | regulation of pH(GO:0006885) |
| 0.2 | 18.1 | GO:0006457 | protein folding(GO:0006457) |
| 5.4 | 16.3 | GO:0043335 | protein unfolding(GO:0043335) |
| 1.9 | 15.1 | GO:0015891 | siderophore transport(GO:0015891) |
| 0.6 | 14.6 | GO:0000422 | mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 66.0 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.6 | 24.6 | GO:0005770 | late endosome(GO:0005770) |
| 0.4 | 18.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 1.6 | 17.2 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 2.1 | 10.3 | GO:0072380 | ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380) |
| 0.1 | 9.9 | GO:0000322 | storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324) |
| 0.0 | 9.8 | GO:0031224 | intrinsic component of membrane(GO:0031224) |
| 0.1 | 8.3 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.4 | 7.4 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.1 | 6.3 | GO:0010008 | endosome membrane(GO:0010008) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 86.3 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 3.9 | 23.2 | GO:0016744 | transferase activity, transferring aldehyde or ketonic groups(GO:0016744) |
| 5.6 | 22.3 | GO:0005537 | mannose binding(GO:0005537) |
| 2.3 | 20.6 | GO:0000149 | SNARE binding(GO:0000149) |
| 4.0 | 16.1 | GO:0015146 | pentose transmembrane transporter activity(GO:0015146) |
| 0.7 | 14.9 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 1.0 | 14.3 | GO:0015293 | symporter activity(GO:0015293) |
| 1.8 | 12.9 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 1.4 | 11.5 | GO:0031072 | heat shock protein binding(GO:0031072) |
| 2.3 | 9.2 | GO:0015603 | siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 106.6 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 3.2 | 9.5 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.6 | 1.7 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.3 | 1.5 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.3 | 1.1 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.3 | 0.9 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.2 | 0.2 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 0.2 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 0.0 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 106.6 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 1.1 | 9.1 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.4 | 3.7 | REACTOME MEIOSIS | Genes involved in Meiosis |
| 0.7 | 2.0 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.6 | 1.8 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.2 | 1.8 | REACTOME DNA REPAIR | Genes involved in DNA Repair |
| 0.5 | 1.5 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.4 | 1.2 | REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION | Genes involved in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| 0.5 | 1.1 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.0 | 0.5 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |