Results for HMRA2
Z-value: 1.65
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Transcription factors associated with HMRA2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
HMRA2
|
S000000692 | Silenced copy of a2 at HMR |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YJR094W-A Show fit | 12.57 |
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein |
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| YHR181W Show fit | 10.20 |
Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment |
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| YPR119W Show fit | 10.20 |
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome |
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| YGR108W Show fit | 10.17 |
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome |
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| YCR018C Show fit | 8.83 |
Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation |
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| YGR034W Show fit | 8.81 |
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Ap and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA |
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| YDR098C Show fit | 8.54 |
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage |
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| YKL209C Show fit | 7.52 |
Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells |
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| YPR010C Show fit | 7.48 |
RNA polymerase I subunit A135 |
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| YHR180W-A Show fit | 7.37 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HMRA2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 149.5 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 1.7 | 23.1 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 2.7 | 19.0 | GO:0010696 | positive regulation of spindle pole body separation(GO:0010696) |
| 0.5 | 17.8 | GO:0006418 | tRNA aminoacylation for protein translation(GO:0006418) |
| 0.1 | 15.4 | GO:0042254 | ribosome biogenesis(GO:0042254) |
| 3.0 | 14.9 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
| 1.3 | 14.6 | GO:0007109 | obsolete cytokinesis, completion of separation(GO:0007109) |
| 0.4 | 12.8 | GO:0006487 | protein N-linked glycosylation(GO:0006487) |
| 0.2 | 12.0 | GO:0030036 | actin cytoskeleton organization(GO:0030036) |
| 1.7 | 11.9 | GO:0043137 | DNA replication, removal of RNA primer(GO:0043137) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 110.1 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 1.3 | 80.1 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.3 | 43.0 | GO:0005933 | cellular bud(GO:0005933) |
| 0.1 | 18.9 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.4 | 17.3 | GO:0030686 | 90S preribosome(GO:0030686) |
| 0.6 | 14.1 | GO:0030173 | integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228) |
| 0.7 | 12.5 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 10.6 | GO:0005730 | nucleolus(GO:0005730) |
| 0.7 | 10.2 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.2 | 9.8 | GO:0043332 | mating projection tip(GO:0043332) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 182.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.1 | 24.7 | GO:0019901 | protein kinase binding(GO:0019901) |
| 0.5 | 18.0 | GO:0016876 | aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876) |
| 4.3 | 12.9 | GO:0003938 | IMP dehydrogenase activity(GO:0003938) |
| 0.4 | 12.1 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.2 | 11.7 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.3 | 11.6 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 2.6 | 10.2 | GO:0005527 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.7 | 10.2 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 0.5 | 9.8 | GO:0030515 | snoRNA binding(GO:0030515) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 4.7 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 1.0 | 3.8 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.9 | 3.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 1.6 | 3.2 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 1.0 | 3.0 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.8 | 2.3 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.5 | 2.0 | PID FGF PATHWAY | FGF signaling pathway |
| 0.4 | 1.2 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 0.4 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.3 | 0.3 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 20.8 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 1.6 | 12.6 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.9 | 6.2 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.7 | 5.1 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 1.2 | 4.8 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.5 | 3.6 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.9 | 3.5 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.8 | 3.4 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 1.0 | 3.1 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.9 | 2.8 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |