Results for HMRA2

Z-value: 1.65

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Transcription factors associated with HMRA2

Gene Symbol Gene ID Gene Info
S000000692 Silenced copy of a2 at HMR

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of HMRA2 motif

Sorted Z-values of HMRA2 motif

Promoter Log-likelihood Transcript Gene Gene Info
YJR094W-A 12.57 Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YHR181W 10.20 Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YPR119W 10.20 B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YGR108W 10.17 B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YCR018C 8.83 Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YGR034W 8.81 Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Ap and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA
YDR098C 8.54 Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YKL209C 7.52 Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells
YPR010C 7.48 RNA polymerase I subunit A135
YHR180W-A 7.37 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3
YNR001W-A 7.21 Dubious open reading frame unlikely to encode a functional protein; identified by homology
YNL066W 7.20 Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family
YOR315W 7.09 Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
YDR033W 7.08 Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YAL059C-A 7.06 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene ECM1/YAL059W
YPR157W 7.02 Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YLR154C 7.01 Ribonuclease H2 subunit, required for RNase H2 activity
YDR023W 6.79 Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
YIL015W 6.77 Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest
YLR449W 6.75 Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones
YLR167W 6.55 Fusion protein that is cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B
YDR041W 6.32 Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
YBL085W 6.19 Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
YBR244W 6.04 Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YGL179C 5.90 Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YFL026W 5.87 Receptor for alpha-factor pheromone; seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells
YMR049C 5.73 Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1
YGL031C 5.63 Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YBR158W 5.57 Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YLR154W-A 5.38 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YLR154W-B 5.37 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YDR040C 5.35 P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance
YOR051C 5.30 Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
YDR502C 5.17 S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YHR201C 5.12 Exopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix
YBR181C 5.02 Protein component of the small (40S) ribosomal subunit; identical to Rps6Ap and has similarity to rat S6 ribosomal protein
YGR251W 4.98 Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YOR369C 4.97 Protein component of the small (40S) ribosomal subunit; has similarity to rat ribosomal protein S12
YLR432W 4.89 Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
YHL003C 4.86 Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p
YDR345C 4.81 Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YKL110C 4.80 Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YLR301W 4.79 Protein of unknown function that interacts with Sec72p
YGL030W 4.78 Protein component of the large (60S) ribosomal subunit, has similarity to rat L30 ribosomal protein; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript
YBL077W 4.59 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C
YGR040W 4.54 Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
YGR145W 4.53 Essential nucleolar protein of unknown function; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p
YHR010W 4.34 Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Bp and has similarity to rat L27 ribosomal protein
YFR032C 4.32 Putative protein of unknown function; transcribed during sporulation; YFR032C is not an essential gene
YJL188C 4.29 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YJL136C 4.29 Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Ap and has similarity to rat S21 ribosomal protein
YJL115W 4.22 Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition
YML056C 4.21 Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
YER073W 4.15 Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed
YIL169C 4.14 Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene
YLR367W 4.11 Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Ap and has similarity to E. coli S8 and rat S15a ribosomal proteins
YER011W 3.99 Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking
YLR206W 3.99 Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
YIL118W 3.93 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YGR036C 3.85 Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation
YOR101W 3.84 GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes
YOL101C 3.84 Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism
YHR216W 3.84 Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation
YOR096W 3.78 Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
YLR441C 3.75 Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Bp and has similarity to rat S3a ribosomal protein
YGR148C 3.70 Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YHR123W 3.61 sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability
YDR418W 3.60 Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins
YMR205C 3.60 Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
YMR277W 3.54 Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p)
YKL218C 3.52 3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YLR048W 3.52 Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Ap; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YMR296C 3.49 Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
YPL178W 3.48 Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif
YDR037W 3.45 Lysyl-tRNA synthetase; also identified as a negative regulator of general control of amino acid biosynthesis
YDR413C 3.45 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the essential uncharacterized ORF YDR412W that is implicated in rRNA processing
YBR011C 3.43 Cytoplasmic inorganic pyrophosphatase (PPase), catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase
YJR032W 3.43 Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity
YCL024W 3.41 Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p
YHR046C 3.40 Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate
YNL178W 3.37 Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YNR054C 3.37 Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
YNL141W 3.37 Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome
YCR034W 3.34 Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway
YER118C 3.32 Transmembrane osmosensor, participates in activation of both the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway
YPL177C 3.32 Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription
YJL200C 3.30 Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
YLR154W-C 3.30 Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YDL047W 3.29 Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
YHL001W 3.27 Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl14Ap and has similarity to rat L14 ribosomal protein
YDL235C 3.27 Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus
YGR052W 3.25 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
YML074C 3.25 Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
YGL201C 3.23 Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YBR066C 3.21 Transcriptional repressor that mediates glucose repression and negatively regulates filamentous growth; has similarity to Nrg1p
YKL182W 3.20 Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
YGL147C 3.17 Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins
YDR297W 3.15 Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis
YER124C 3.13 Daughter cell-specific protein, may participate in pathways regulating cell wall metabolism; deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall
YEL053W-A 3.09 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YEL054C
YOR008C-A 3.07 Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres
YDL055C 3.04 GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YML026C 3.04 Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Ap and has similarity to E. coli S13 and rat S18 ribosomal proteins
YJR070C 3.03 Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyses hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning
YOL130W 2.97 Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions
YER137C 2.96 Putative protein of unknown function
YLR249W 2.95 Translational elongation factor 3, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex; contains two ABC cassettes; binds and hydrolyses ATP
YJR071W 2.92 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR102C 2.91 Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
YER074W 2.89 Protein component of the small (40S) ribosomal subunit; identical to Rps24Bp and has similarity to rat S24 ribosomal protein
YOR029W 2.89 Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YER049W 2.88 Protein of unknown function; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; has a role in translation termination efficiency, mRNA poly(A) tail length and mRNA stability
YHR141C 2.87 Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to rat L44; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus
YCL023C 2.86 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4
YFL027C 2.85 GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport
YOR025W 2.85 Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
YKL216W 2.83 Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid
YGL097W 2.80 Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
YGL158W 2.79 Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations
YER131W 2.79 Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YOL014W 2.77 Putative protein of unknown function
YGL032C 2.77 Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds
YER026C 2.75 Phosphatidylserine synthase, functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline
YHR127W 2.73 Protein of unknown function; localizes to the nucleus
YOR314W 2.69 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL029W 2.67 Protein involved in nucleolar integrity and processing of the pre-rRNA for the 60S ribosome subunit; transcript is induced in response to cytotoxic stress but not genotoxic stress
YCR031C 2.67 Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins
YGR086C 2.66 Primary component of eisosomes, which are large immobile cell cortex structures associated with endocytosis; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria
YDR101C 2.66 Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
YGR050C 2.65 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR028C 2.60 Basic leucine zipper transcriptional factor of the yAP-1 family that mediates pleiotropic drug resistance and salt tolerance; localizes constitutively to the nucleus
YGR055W 2.59 High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
YDL211C 2.58 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YOR313C 2.58 Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage
YFR055W 2.57 Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YLR075W 2.56 Protein component of the large (60S) ribosomal subunit, responsible for joining the 40S and 60S subunits; regulates translation initiation; has similarity to rat L10 ribosomal protein and to members of the QM gene family
YCL050C 2.55 Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase I (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa2p
YIR020C-B 2.54 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF MRS1
YLR222C 2.54 Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YJL011C 2.49 RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex
YER056C-A 2.49 Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Bp and has similarity to rat L34 ribosomal protein
YOL086C 2.48 Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YLR406C 2.48 Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Ap and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p
YNR013C 2.48 Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YKL165C 2.47 Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes
YHR193C 2.45 Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes
YPR122W 2.43 Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells
YOL056W 2.42 Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
YDR261C 2.42 Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YLR257W 2.42 Putative protein of unknown function
YDL082W 2.41 Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Bp; not essential for viability; has similarity to rat L13 ribosomal protein
YJL105W 2.40 Protein of unknown function, contains a SET domain
YGR280C 2.39 Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain
YDL084W 2.38 Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56
YDL134C 2.38 Catalytic subunit of protein phosphatase 2A, functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis
YDL240W 2.38 Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis
YER055C 2.37 ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
YPR033C 2.36 Cytoplasmic and mitochondrial histidine tRNA synthetase; encoded by a single nuclear gene that specifies two messages; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence
YLR328W 2.35 Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways
YEL027W 2.35 Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis
YML073C 2.34 N-terminally acetylated protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Bp and to rat L6 ribosomal protein; binds to 5.8S rRNA
YER136W 2.33 GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins
YGR249W 2.33 Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants
YML119W 2.33 Putative protein of unknown funtion; YML119W is not an essential gene; potential Cdc28p substrate
YDL083C 2.31 Protein component of the small (40S) ribosomal subunit; identical to Rps16Ap and has similarity to E. coli S9 and rat S16 ribosomal proteins
YDR075W 2.29 Catalytic subunit of an evolutionarily conserved protein phosphatase complex containing Psy2p and the regulatory subunit Psy4p; required for cisplatin resistance; involved in activation of Gln3p
YNL170W 2.29 Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YJL198W 2.28 Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YOL038W 2.27 Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress
YLR265C 2.27 Protein involved in regulation of nonhomologous end joining; interacts with DNA ligase IV components Dnl4p and Lif1p; repressed by MAT heterozygosity; regulates cellular distribution of Lif1p
YJL008C 2.27 Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YBR243C 2.27 UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
YFR056C 2.27 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YEL029C 2.27 Putative pyridoxal kinase, key enzyme in vitamin B6 metabolism; involved in maintaining levels of pyridoxal 5'-phosphate, the active form of vitamin B6; required for genome integrity; homolog of E. coli PdxK; involved in bud-site selection
YPL249C-A 2.26 Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Ap and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA
YOL127W 2.26 Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 26S rRNA via a conserved C-terminal motif
YIL133C 2.25 N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
YMR032W 2.25 Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p
YER134C 2.25 Putative protein of unknown function; non-essential gene
YKL166C 2.24 cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk1p and Tpk2p
YDR447C 2.23 Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Ap and has similarity to rat S17 ribosomal protein
YBR121C 2.23 Cytoplasmic and mitochondrial glycyl-tRNA synthase that ligates glycine to the cognate anticodon bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation
YOR342C 2.23 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YKL096W-A 2.22 Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YGL028C 2.21 Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p
YJR043C 2.21 Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p
YLL012W 2.20 Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
YDR144C 2.20 GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p
YPL250W-A 2.18 Identified by fungal homology and RT-PCR
YLR413W 2.18 Putative protein of unknown function; YLR413W is not an essential gene
YOR361C 2.16 Subunit of the core complex of translation initiation factor 3(eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes
YMR142C 2.16 Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Ap; not essential for viability; has similarity to rat L13 ribosomal protein
YMR015C 2.15 C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
YMR143W 2.15 Protein component of the small (40S) ribosomal subunit; identical to Rps16Bp and has similarity to E. coli S9 and rat S16 ribosomal proteins
YHL034W-A 2.15 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL111C 2.15 Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
YER117W 2.14 Protein component of the large (60S) ribosomal subunit, identical to Rpl23Ap and has similarity to E. coli L14 and rat L23 ribosomal proteins
YPL225W 2.13 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YCR022C 2.13 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene
YGR159C 2.12 Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis

Network of associatons between targets according to the STRING database.

First level regulatory network of HMRA2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 14.9 GO:0006177 GMP biosynthetic process(GO:0006177)
2.7 19.0 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
2.0 7.8 GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000461)
1.7 11.9 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
1.7 23.1 GO:0000028 ribosomal small subunit assembly(GO:0000028)
1.6 6.4 GO:0031057 negative regulation of histone modification(GO:0031057)
1.6 4.8 GO:0006407 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
1.6 4.7 GO:0006798 polyphosphate catabolic process(GO:0006798)
1.6 3.1 GO:0046838 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
1.5 4.5 GO:0043484 regulation of RNA splicing(GO:0043484) regulation of mRNA splicing, via spliceosome(GO:0048024)
1.4 4.2 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
1.4 5.6 GO:0030497 fatty acid elongation(GO:0030497)
1.3 14.6 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
1.3 4.0 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
1.3 5.2 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
1.3 2.6 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
1.2 4.7 GO:0046898 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
1.2 4.6 GO:2000756 regulation of histone acetylation(GO:0035065) positive regulation of histone acetylation(GO:0035066) regulation of protein acetylation(GO:1901983) positive regulation of protein acetylation(GO:1901985) regulation of peptidyl-lysine acetylation(GO:2000756) positive regulation of peptidyl-lysine acetylation(GO:2000758)
1.1 4.5 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
1.1 3.4 GO:0046113 adenine metabolic process(GO:0046083) nucleobase catabolic process(GO:0046113)
1.1 6.7 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
1.1 3.3 GO:0035953 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
1.1 4.4 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
1.1 149.5 GO:0002181 cytoplasmic translation(GO:0002181)
1.0 7.2 GO:0043171 peptide catabolic process(GO:0043171)
1.0 3.0 GO:0009298 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
1.0 9.1 GO:0006814 sodium ion transport(GO:0006814)
1.0 3.9 GO:0000296 spermine transport(GO:0000296)
1.0 10.5 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.9 11.3 GO:0090529 barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529)
0.9 5.7 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.9 4.7 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.9 3.7 GO:0090338 regulation of formin-nucleated actin cable assembly(GO:0090337) positive regulation of formin-nucleated actin cable assembly(GO:0090338)
0.9 3.4 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.8 5.1 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.8 2.5 GO:2000001 regulation of cell cycle checkpoint(GO:1901976) negative regulation of cell cycle checkpoint(GO:1901977) regulation of DNA damage checkpoint(GO:2000001) negative regulation of DNA damage checkpoint(GO:2000002) negative regulation of response to DNA damage stimulus(GO:2001021)
0.8 3.3 GO:0042256 mature ribosome assembly(GO:0042256)
0.8 5.7 GO:0030030 cell projection organization(GO:0030030) cell projection assembly(GO:0030031)
0.8 1.6 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
0.8 3.2 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
0.8 0.8 GO:0070189 kynurenine metabolic process(GO:0070189)
0.8 6.3 GO:0042538 hyperosmotic salinity response(GO:0042538)
0.8 2.3 GO:0015693 magnesium ion transport(GO:0015693)
0.8 3.1 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211) negative regulation of telomere maintenance via telomere lengthening(GO:1904357)
0.8 3.0 GO:0007234 osmosensory signaling via phosphorelay pathway(GO:0007234)
0.7 5.2 GO:0046513 ceramide metabolic process(GO:0006672) ceramide biosynthetic process(GO:0046513)
0.7 2.9 GO:0019287 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490)
0.7 2.9 GO:0060188 regulation of protein desumoylation(GO:0060188)
0.7 0.7 GO:0045901 positive regulation of translational elongation(GO:0045901)
0.7 2.0 GO:0051439 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.7 2.7 GO:0015867 ATP transport(GO:0015867)
0.7 2.0 GO:0000101 sulfur amino acid transport(GO:0000101)
0.6 2.6 GO:0098610 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.6 7.4 GO:0007120 axial cellular bud site selection(GO:0007120)
0.6 2.4 GO:0034473 U1 snRNA 3'-end processing(GO:0034473)
0.6 10.9 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.6 1.2 GO:1903313 positive regulation of mRNA metabolic process(GO:1903313)
0.6 3.6 GO:0045014 negative regulation of transcription from RNA polymerase II promoter by glucose(GO:0000433) negative regulation of transcription by glucose(GO:0045014)
0.6 1.8 GO:0006531 aspartate metabolic process(GO:0006531)
0.6 1.2 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.6 1.2 GO:0065005 lipid tube assembly(GO:0060988) protein-lipid complex assembly(GO:0065005) protein-lipid complex subunit organization(GO:0071825)
0.6 2.3 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
0.6 1.7 GO:0034310 ethanol catabolic process(GO:0006068) primary alcohol catabolic process(GO:0034310)
0.6 6.9 GO:0006415 translational termination(GO:0006415)
0.5 17.8 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.5 9.6 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.5 0.5 GO:0071902 positive regulation of protein serine/threonine kinase activity(GO:0071902)
0.5 1.6 GO:0040031 snRNA pseudouridine synthesis(GO:0031120) snRNA modification(GO:0040031)
0.5 2.1 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.5 3.6 GO:0061572 actin filament bundle assembly(GO:0051017) actin filament bundle organization(GO:0061572)
0.5 0.5 GO:0071482 cellular response to radiation(GO:0071478) cellular response to light stimulus(GO:0071482)
0.5 0.5 GO:0046037 GMP metabolic process(GO:0046037)
0.5 4.3 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.5 1.4 GO:0006721 terpenoid metabolic process(GO:0006721) terpenoid biosynthetic process(GO:0016114) farnesyl diphosphate biosynthetic process(GO:0045337) farnesyl diphosphate metabolic process(GO:0045338)
0.5 2.8 GO:0033313 meiotic cell cycle checkpoint(GO:0033313) meiotic recombination checkpoint(GO:0051598)
0.5 1.4 GO:1900101 regulation of endoplasmic reticulum unfolded protein response(GO:1900101)
0.5 6.4 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.5 0.9 GO:0033262 regulation of nuclear cell cycle DNA replication(GO:0033262)
0.4 1.3 GO:0006567 threonine catabolic process(GO:0006567)
0.4 1.8 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.4 5.2 GO:0030011 maintenance of cell polarity(GO:0030011)
0.4 6.1 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.4 1.7 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.4 3.0 GO:0032988 ribonucleoprotein complex disassembly(GO:0032988)
0.4 2.5 GO:0009164 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.4 2.9 GO:0015791 polyol transport(GO:0015791)
0.4 5.0 GO:0015833 peptide transport(GO:0015833)
0.4 7.3 GO:0030488 tRNA methylation(GO:0030488)
0.4 2.4 GO:0070941 eisosome assembly(GO:0070941)
0.4 0.8 GO:0016094 polyprenol metabolic process(GO:0016093) polyprenol biosynthetic process(GO:0016094) dolichol metabolic process(GO:0019348) dolichol biosynthetic process(GO:0019408)
0.4 1.2 GO:0009302 snoRNA transcription from an RNA polymerase II promoter(GO:0001015) snoRNA transcription(GO:0009302)
0.4 3.2 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.4 1.6 GO:0044070 regulation of anion transport(GO:0044070)
0.4 0.8 GO:0090180 regulation of vitamin metabolic process(GO:0030656) positive regulation of vitamin metabolic process(GO:0046136) positive regulation of sulfur metabolic process(GO:0051176) regulation of thiamine biosynthetic process(GO:0070623) positive regulation of thiamine biosynthetic process(GO:0090180)
0.4 1.9 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.4 1.5 GO:0030042 actin filament depolymerization(GO:0030042)
0.4 12.8 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.4 0.4 GO:0030307 positive regulation of cell growth(GO:0030307) positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter(GO:1900461) positive regulation of pseudohyphal growth(GO:2000222)
0.4 1.4 GO:0009423 chorismate biosynthetic process(GO:0009423)
0.4 1.8 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.4 1.1 GO:0008272 sulfate transport(GO:0008272)
0.4 1.8 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.4 3.6 GO:0006882 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.4 1.8 GO:0072668 obsolete tubulin complex biogenesis(GO:0072668)
0.3 9.4 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.3 2.1 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.3 1.0 GO:1901351 regulation of phosphatidylglycerol biosynthetic process(GO:1901351) negative regulation of phosphatidylglycerol biosynthetic process(GO:1901352)
0.3 1.3 GO:0035337 fatty-acyl-CoA metabolic process(GO:0035337)
0.3 3.6 GO:0072503 cellular divalent inorganic cation homeostasis(GO:0072503) divalent inorganic cation homeostasis(GO:0072507)
0.3 1.0 GO:0031335 regulation of sulfur amino acid metabolic process(GO:0031335)
0.3 2.3 GO:0001402 signal transduction involved in filamentous growth(GO:0001402)
0.3 1.6 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity(GO:0051090)
0.3 0.9 GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)(GO:0000388)
0.3 2.8 GO:0006450 regulation of translational fidelity(GO:0006450)
0.3 1.3 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.3 1.2 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.3 7.4 GO:0002097 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.3 11.4 GO:0033750 ribosomal subunit export from nucleus(GO:0000054) ribosome localization(GO:0033750) establishment of ribosome localization(GO:0033753)
0.3 7.6 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.3 2.1 GO:1902707 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
0.3 1.5 GO:0070814 hydrogen sulfide metabolic process(GO:0070813) hydrogen sulfide biosynthetic process(GO:0070814)
0.3 8.0 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.3 0.9 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.3 3.8 GO:0000147 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.3 1.7 GO:0000743 nuclear migration involved in conjugation with cellular fusion(GO:0000743)
0.3 0.3 GO:0034724 DNA replication-independent nucleosome organization(GO:0034724)
0.3 1.7 GO:0009099 valine biosynthetic process(GO:0009099)
0.3 1.7 GO:0007030 Golgi organization(GO:0007030)
0.3 0.3 GO:0032271 regulation of protein polymerization(GO:0032271) positive regulation of protein polymerization(GO:0032273)
0.3 7.4 GO:0006694 steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126)
0.3 1.6 GO:0009312 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.3 0.8 GO:0034091 maintenance of meiotic sister chromatid cohesion(GO:0034090) regulation of maintenance of sister chromatid cohesion(GO:0034091) positive regulation of sister chromatid cohesion(GO:0045876)
0.3 2.4 GO:0009435 NAD biosynthetic process(GO:0009435)
0.3 1.1 GO:0019184 glutathione biosynthetic process(GO:0006750) nonribosomal peptide biosynthetic process(GO:0019184)
0.3 2.7 GO:0043488 regulation of RNA stability(GO:0043487) regulation of mRNA stability(GO:0043488)
0.3 2.1 GO:0030846 termination of RNA polymerase II transcription, poly(A)-coupled(GO:0030846)
0.3 2.1 GO:0000022 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231)
0.3 1.1 GO:0007121 bipolar cellular bud site selection(GO:0007121)
0.3 1.1 GO:0009226 nucleotide-sugar biosynthetic process(GO:0009226)
0.3 2.1 GO:0015939 pantothenate metabolic process(GO:0015939) pantothenate biosynthetic process(GO:0015940)
0.3 1.0 GO:0006279 premeiotic DNA replication(GO:0006279)
0.3 0.5 GO:0046495 nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637)
0.3 3.3 GO:0018208 protein peptidyl-prolyl isomerization(GO:0000413) peptidyl-proline modification(GO:0018208)
0.2 0.5 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.2 5.4 GO:0006885 regulation of pH(GO:0006885)
0.2 1.2 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.2 0.2 GO:0009179 purine nucleoside diphosphate metabolic process(GO:0009135) purine ribonucleoside diphosphate metabolic process(GO:0009179) ribonucleoside diphosphate metabolic process(GO:0009185) ADP metabolic process(GO:0046031)
0.2 0.9 GO:0043470 regulation of carbohydrate catabolic process(GO:0043470) regulation of cellular carbohydrate catabolic process(GO:0043471)
0.2 1.4 GO:0072595 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437) maintenance of protein localization in organelle(GO:0072595)
0.2 0.2 GO:0042710 biofilm formation(GO:0042710)
0.2 9.1 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.2 0.2 GO:0043242 negative regulation of protein complex disassembly(GO:0043242)
0.2 12.0 GO:0030036 actin cytoskeleton organization(GO:0030036)
0.2 0.9 GO:0072396 cellular response to biotic stimulus(GO:0071216) response to cell cycle checkpoint signaling(GO:0072396) response to mitotic cell cycle checkpoint signaling(GO:0072414) response to spindle checkpoint signaling(GO:0072417) response to mitotic spindle checkpoint signaling(GO:0072476) response to mitotic cell cycle spindle assembly checkpoint signaling(GO:0072479) response to spindle assembly checkpoint signaling(GO:0072485) negative regulation of protein import into nucleus during spindle assembly checkpoint(GO:1901925)
0.2 0.6 GO:0001111 promoter clearance during DNA-templated transcription(GO:0001109) promoter clearance from RNA polymerase II promoter(GO:0001111)
0.2 0.8 GO:0008655 pyrimidine-containing compound salvage(GO:0008655)
0.2 8.1 GO:0006413 translational initiation(GO:0006413)
0.2 0.4 GO:0071454 response to anoxia(GO:0034059) cellular response to anoxia(GO:0071454)
0.2 0.6 GO:0042992 regulation of transcription factor import into nucleus(GO:0042990) negative regulation of transcription factor import into nucleus(GO:0042992)
0.2 0.8 GO:0015680 intracellular copper ion transport(GO:0015680)
0.2 1.4 GO:0046501 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.2 0.2 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
0.2 3.7 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.2 0.2 GO:0071051 polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.2 3.9 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.2 1.5 GO:0016125 steroid metabolic process(GO:0008202) sterol metabolic process(GO:0016125)
0.2 0.6 GO:0046777 protein autophosphorylation(GO:0046777)
0.2 1.3 GO:0044091 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.2 0.6 GO:0046901 tetrahydrofolylpolyglutamate metabolic process(GO:0046900) tetrahydrofolylpolyglutamate biosynthetic process(GO:0046901)
0.2 2.2 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.2 1.4 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.2 0.5 GO:0009262 deoxyribonucleotide metabolic process(GO:0009262) deoxyribonucleotide biosynthetic process(GO:0009263)
0.2 1.3 GO:0007000 nucleolus organization(GO:0007000)
0.2 0.4 GO:0033523 histone H2B ubiquitination(GO:0033523) histone H2B conserved C-terminal lysine ubiquitination(GO:0071894) regulation of histone H2B ubiquitination(GO:2001166) regulation of histone H2B conserved C-terminal lysine ubiquitination(GO:2001173)
0.2 0.9 GO:0043007 maintenance of rDNA(GO:0043007)
0.2 0.5 GO:2001057 reactive nitrogen species metabolic process(GO:2001057)
0.2 1.3 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.2 0.7 GO:0048279 vesicle fusion with endoplasmic reticulum(GO:0048279)
0.2 0.3 GO:0006657 CDP-choline pathway(GO:0006657)
0.2 1.3 GO:0009303 rRNA transcription(GO:0009303)
0.2 1.8 GO:0045002 double-strand break repair via single-strand annealing(GO:0045002)
0.2 0.3 GO:0031292 gene conversion at mating-type locus, DNA double-strand break processing(GO:0031292)
0.2 0.6 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.2 0.6 GO:0015883 FAD transport(GO:0015883)
0.2 2.5 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.2 0.9 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.2 0.8 GO:0015780 nucleotide-sugar transport(GO:0015780)
0.1 3.1 GO:0006334 nucleosome assembly(GO:0006334)
0.1 15.4 GO:0042254 ribosome biogenesis(GO:0042254)
0.1 2.2 GO:0009304 tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.1 0.7 GO:0006797 polyphosphate metabolic process(GO:0006797)
0.1 1.4 GO:0052803 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.1 1.6 GO:0051647 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023) nucleus localization(GO:0051647)
0.1 1.7 GO:0043094 cellular metabolic compound salvage(GO:0043094)
0.1 0.3 GO:0006448 regulation of translational elongation(GO:0006448)
0.1 1.4 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.1 0.8 GO:0006768 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.1 2.6 GO:0006400 tRNA modification(GO:0006400)
0.1 0.3 GO:0009094 L-phenylalanine biosynthetic process(GO:0009094) erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process(GO:1902223)
0.1 0.5 GO:0034661 ncRNA catabolic process(GO:0034661)
0.1 0.9 GO:0000376 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.1 0.9 GO:0051278 cell wall chitin biosynthetic process(GO:0006038) fungal-type cell wall chitin biosynthetic process(GO:0034221) fungal-type cell wall polysaccharide biosynthetic process(GO:0051278) cell wall polysaccharide biosynthetic process(GO:0070592) fungal-type cell wall polysaccharide metabolic process(GO:0071966)
0.1 0.6 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.1 1.0 GO:0016074 snoRNA metabolic process(GO:0016074)
0.1 0.4 GO:0045833 negative regulation of lipid metabolic process(GO:0045833)
0.1 0.7 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.1 0.9 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.1 0.3 GO:0010383 cell wall chitin metabolic process(GO:0006037) cell wall polysaccharide metabolic process(GO:0010383)
0.1 1.0 GO:0006206 pyrimidine nucleobase metabolic process(GO:0006206)
0.1 0.2 GO:0000957 mitochondrial RNA catabolic process(GO:0000957)
0.1 1.2 GO:0000011 vacuole inheritance(GO:0000011)
0.1 0.3 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.1 0.9 GO:0006613 cotranslational protein targeting to membrane(GO:0006613) SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.1 0.7 GO:0007323 peptide pheromone maturation(GO:0007323)
0.1 0.5 GO:0009309 tryptophan biosynthetic process(GO:0000162) amine biosynthetic process(GO:0009309) cellular biogenic amine biosynthetic process(GO:0042401) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
0.1 0.2 GO:0016320 endoplasmic reticulum membrane fusion(GO:0016320)
0.1 0.4 GO:0007535 donor selection(GO:0007535)
0.1 0.6 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.1 0.5 GO:0006998 nuclear envelope organization(GO:0006998)
0.1 0.7 GO:0006878 cellular copper ion homeostasis(GO:0006878) copper ion homeostasis(GO:0055070)
0.1 0.3 GO:0060277 obsolete negative regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0060277)
0.1 1.2 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 2.0 GO:0006612 protein targeting to membrane(GO:0006612)
0.1 0.6 GO:0090522 vesicle tethering involved in exocytosis(GO:0090522)
0.1 0.4 GO:0009306 protein secretion(GO:0009306)
0.1 0.4 GO:0072337 modified amino acid transport(GO:0072337)
0.1 0.8 GO:0006379 mRNA cleavage(GO:0006379)
0.1 1.2 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 0.4 GO:0009088 threonine biosynthetic process(GO:0009088)
0.1 1.1 GO:0006337 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.1 0.4 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.1 0.3 GO:0008033 tRNA processing(GO:0008033)
0.1 4.0 GO:0006457 protein folding(GO:0006457)
0.1 0.1 GO:0006343 establishment of chromatin silencing(GO:0006343)
0.1 0.4 GO:0009231 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.1 0.1 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.1 0.3 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 0.2 GO:0006517 protein deglycosylation(GO:0006517)
0.1 0.2 GO:0006114 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.1 0.1 GO:0009249 protein lipoylation(GO:0009249)
0.1 0.3 GO:0000733 DNA strand renaturation(GO:0000733)
0.1 0.3 GO:0022615 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.1 1.4 GO:0043087 regulation of GTPase activity(GO:0043087)
0.1 0.2 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.0 0.1 GO:0006562 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
0.0 0.2 GO:0006272 leading strand elongation(GO:0006272)
0.0 0.2 GO:0016233 telomere capping(GO:0016233)
0.0 1.8 GO:0051028 mRNA transport(GO:0051028)
0.0 0.2 GO:0032508 DNA duplex unwinding(GO:0032508)
0.0 0.1 GO:0019359 nicotinamide nucleotide biosynthetic process(GO:0019359) pyridine nucleotide biosynthetic process(GO:0019363)
0.0 0.1 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.0 0.2 GO:0046112 nucleobase biosynthetic process(GO:0046112)
0.0 0.3 GO:0006273 lagging strand elongation(GO:0006273)
0.0 0.1 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.0 0.2 GO:0097549 heterochromatin organization involved in chromatin silencing(GO:0070868) chromatin organization involved in negative regulation of transcription(GO:0097549)
0.0 0.8 GO:0045324 late endosome to vacuole transport(GO:0045324)
0.0 0.0 GO:0051664 nuclear pore distribution(GO:0031081) nuclear pore localization(GO:0051664)
0.0 0.1 GO:0010978 gene silencing involved in chronological cell aging(GO:0010978) gene silencing by RNA(GO:0031047)
0.0 0.1 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 2.5 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.2 GO:0010526 negative regulation of transposition, RNA-mediated(GO:0010526) negative regulation of transposition(GO:0010529)
0.0 0.1 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.2 GO:0010388 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.0 0.1 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183) peptidyl-histidine modification(GO:0018202)
0.0 0.5 GO:0046467 GPI anchor biosynthetic process(GO:0006506) membrane lipid biosynthetic process(GO:0046467)
0.0 0.0 GO:0006356 regulation of transcription from RNA polymerase I promoter(GO:0006356)
0.0 0.1 GO:0009112 nucleobase metabolic process(GO:0009112)
0.0 0.3 GO:0046856 phospholipid dephosphorylation(GO:0046839) phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.2 GO:0007052 mitotic spindle organization(GO:0007052)
0.0 0.1 GO:0046160 heme a biosynthetic process(GO:0006784) heme a metabolic process(GO:0046160)
0.0 0.1 GO:0009373 regulation of transcription by pheromones(GO:0009373) negative regulation of transcription by pheromones(GO:0045996) regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046019) negative regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046020)
0.0 0.3 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.2 GO:0015918 sterol transport(GO:0015918)
0.0 0.1 GO:0006284 base-excision repair(GO:0006284)
0.0 0.1 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.1 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 0.1 GO:0034249 negative regulation of translation(GO:0017148) negative regulation of cellular amide metabolic process(GO:0034249)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.5 GO:0032299 ribonuclease H2 complex(GO:0032299)
1.9 5.7 GO:0070545 PeBoW complex(GO:0070545)
1.7 6.7 GO:0030287 cell wall-bounded periplasmic space(GO:0030287)
1.5 6.0 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
1.4 5.6 GO:0044697 HICS complex(GO:0044697)
1.3 4.0 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
1.3 4.0 GO:0043625 delta DNA polymerase complex(GO:0043625)
1.3 80.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
1.3 110.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
1.2 4.6 GO:0042597 periplasmic space(GO:0042597)
1.1 5.5 GO:0034518 RNA cap binding complex(GO:0034518)
1.1 4.4 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
1.1 3.3 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.9 2.6 GO:0072687 meiotic spindle(GO:0072687)
0.8 5.1 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.8 3.8 GO:0030689 Noc complex(GO:0030689)
0.8 4.6 GO:0035339 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.7 12.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.7 10.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.7 2.0 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.7 2.0 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
0.6 14.1 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.6 0.6 GO:0000145 exocyst(GO:0000145)
0.6 2.4 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.6 2.4 GO:0005797 Golgi medial cisterna(GO:0005797)
0.6 3.6 GO:0042555 MCM complex(GO:0042555)
0.6 1.7 GO:0005827 polar microtubule(GO:0005827) tubulin complex(GO:0045298)
0.5 1.6 GO:0030428 cell septum(GO:0030428)
0.5 3.7 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.5 1.6 GO:0046930 pore complex(GO:0046930)
0.5 1.5 GO:0008275 gamma-tubulin small complex, spindle pole body(GO:0000928) gamma-tubulin complex(GO:0000930) gamma-tubulin small complex(GO:0008275)
0.5 3.0 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.5 2.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.5 2.4 GO:0030478 actin cap(GO:0030478)
0.5 3.2 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.4 1.7 GO:0030008 TRAPP complex(GO:0030008)
0.4 1.7 GO:0044462 cell wall part(GO:0044426) external encapsulating structure part(GO:0044462)
0.4 1.7 GO:0005880 nuclear microtubule(GO:0005880)
0.4 1.3 GO:0016363 nuclear matrix(GO:0016363)
0.4 1.3 GO:0097344 Rix1 complex(GO:0097344)
0.4 4.6 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.4 2.8 GO:0032432 actin filament bundle(GO:0032432)
0.4 1.9 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.4 17.3 GO:0030686 90S preribosome(GO:0030686)
0.4 1.1 GO:0071261 Ssh1 translocon complex(GO:0071261)
0.4 1.1 GO:0005955 calcineurin complex(GO:0005955)
0.4 2.6 GO:0033180 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.4 1.5 GO:0042788 polysomal ribosome(GO:0042788)
0.4 2.6 GO:0000346 transcription export complex(GO:0000346)
0.4 2.5 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.4 3.5 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.3 1.0 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.3 1.4 GO:0070860 RNA polymerase I core factor complex(GO:0070860)
0.3 4.1 GO:0005940 septin ring(GO:0005940)
0.3 2.4 GO:0051233 spindle midzone(GO:0051233)
0.3 2.1 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.3 0.3 GO:0000131 incipient cellular bud site(GO:0000131)
0.3 2.3 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.3 2.6 GO:0005688 U6 snRNP(GO:0005688)
0.3 1.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.3 1.9 GO:0072686 mitotic spindle(GO:0072686)
0.3 0.9 GO:0005662 DNA replication factor A complex(GO:0005662)
0.3 0.9 GO:0043291 RAVE complex(GO:0043291)
0.3 5.1 GO:0022626 cytosolic ribosome(GO:0022626)
0.3 1.2 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.3 0.9 GO:0000137 Golgi cis cisterna(GO:0000137)
0.3 1.1 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.3 4.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.3 2.2 GO:0005637 nuclear inner membrane(GO:0005637)
0.3 1.6 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.3 6.1 GO:0005844 polysome(GO:0005844)
0.3 1.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.3 1.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.3 1.0 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.3 43.0 GO:0005933 cellular bud(GO:0005933)
0.3 1.5 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.2 6.4 GO:0044445 cytosolic part(GO:0044445)
0.2 3.2 GO:0000786 nucleosome(GO:0000786)
0.2 9.8 GO:0043332 mating projection tip(GO:0043332)
0.2 0.7 GO:0005796 Golgi lumen(GO:0005796)
0.2 1.9 GO:0005724 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.2 0.9 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.2 0.9 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205) Sec62/Sec63 complex(GO:0031207)
0.2 2.0 GO:0005801 cis-Golgi network(GO:0005801)
0.2 4.6 GO:0005887 integral component of plasma membrane(GO:0005887)
0.2 1.1 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.2 0.6 GO:0043529 GET complex(GO:0043529)
0.2 0.6 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.2 0.6 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.2 0.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 1.0 GO:0005641 nuclear envelope lumen(GO:0005641)
0.2 0.8 GO:0032126 eisosome(GO:0032126)
0.2 0.8 GO:0000444 MIS12/MIND type complex(GO:0000444) nuclear MIS12/MIND complex(GO:0000818)
0.2 4.8 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.2 6.0 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.2 0.7 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.2 0.4 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.2 2.5 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.2 2.3 GO:0036452 ESCRT complex(GO:0036452)
0.2 5.5 GO:0015935 small ribosomal subunit(GO:0015935)
0.2 1.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.2 1.0 GO:0031080 nuclear pore outer ring(GO:0031080)
0.2 0.5 GO:0033553 rDNA heterochromatin(GO:0033553)
0.2 0.5 GO:0000262 cytoplasmic chromosome(GO:0000229) mitochondrial chromosome(GO:0000262)
0.2 0.8 GO:0031262 Ndc80 complex(GO:0031262)
0.2 0.5 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.2 1.1 GO:0017119 Golgi transport complex(GO:0017119)
0.1 1.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 1.9 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 0.6 GO:0033176 vacuolar proton-transporting V-type ATPase complex(GO:0016471) proton-transporting V-type ATPase complex(GO:0033176)
0.1 0.3 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 0.5 GO:0000500 RNA polymerase I upstream activating factor complex(GO:0000500)
0.1 0.5 GO:0097196 Shu complex(GO:0097196)
0.1 0.4 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 0.9 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 0.5 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.1 1.3 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 1.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 2.0 GO:0016586 RSC complex(GO:0016586)
0.1 0.4 GO:0070939 Dsl1p complex(GO:0070939)
0.1 1.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 0.6 GO:0031414 N-terminal protein acetyltransferase complex(GO:0031414)
0.1 1.5 GO:0005635 nuclear envelope(GO:0005635)
0.1 0.3 GO:0005823 central plaque of spindle pole body(GO:0005823)
0.1 0.6 GO:0000799 condensin complex(GO:0000796) nuclear condensin complex(GO:0000799)
0.1 0.4 GO:0000811 GINS complex(GO:0000811)
0.1 0.2 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.1 0.1 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.1 0.6 GO:0008278 nuclear cohesin complex(GO:0000798) cohesin complex(GO:0008278)
0.1 0.3 GO:0032301 MutSalpha complex(GO:0032301)
0.1 6.5 GO:0005618 cell wall(GO:0005618) external encapsulating structure(GO:0030312)
0.1 0.4 GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network(GO:0042175)
0.1 0.6 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.1 0.1 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.1 2.4 GO:0071010 U2-type prespliceosome(GO:0071004) prespliceosome(GO:0071010)
0.1 1.7 GO:0005802 trans-Golgi network(GO:0005802)
0.1 0.2 GO:0030869 RENT complex(GO:0030869)
0.1 0.7 GO:0042575 DNA polymerase complex(GO:0042575)
0.1 10.6 GO:0005730 nucleolus(GO:0005730)
0.1 0.6 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.1 1.2 GO:0046695 SLIK (SAGA-like) complex(GO:0046695)
0.1 2.6 GO:0000781 chromosome, telomeric region(GO:0000781)
0.1 18.9 GO:0005783 endoplasmic reticulum(GO:0005783)
0.1 1.1 GO:0097526 U4/U6 x U5 tri-snRNP complex(GO:0046540) spliceosomal tri-snRNP complex(GO:0097526)
0.1 0.5 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 0.3 GO:0045254 mitochondrial pyruvate dehydrogenase complex(GO:0005967) pyruvate dehydrogenase complex(GO:0045254)
0.1 0.5 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.1 0.3 GO:0032221 Rpd3S complex(GO:0032221)
0.1 0.4 GO:0098799 outer mitochondrial membrane protein complex(GO:0098799)
0.1 0.2 GO:0032807 DNA ligase IV complex(GO:0032807)
0.1 0.3 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.1 0.2 GO:0034044 exomer complex(GO:0034044)
0.1 0.1 GO:0005825 half bridge of spindle pole body(GO:0005825)
0.0 0.2 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.4 GO:0030286 dynein complex(GO:0030286)
0.0 0.6 GO:0005576 extracellular region(GO:0005576)
0.0 0.3 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.1 GO:0000178 exosome (RNase complex)(GO:0000178)
0.0 0.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.2 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.1 GO:0070823 HDA1 complex(GO:0070823)
0.0 0.1 GO:0030904 retromer complex(GO:0030904)
0.0 0.2 GO:0000439 core TFIIH complex(GO:0000439)
0.0 0.1 GO:0033186 CAF-1 complex(GO:0033186)
0.0 1.0 GO:0005643 nuclear pore(GO:0005643)
0.0 0.1 GO:0000938 GARP complex(GO:0000938)
0.0 0.9 GO:0005819 spindle(GO:0005819)
0.0 0.2 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 0.1 GO:0034448 EGO complex(GO:0034448)
0.0 0.4 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.0 0.1 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.1 GO:0070772 PAS complex(GO:0070772)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 12.9 GO:0003938 IMP dehydrogenase activity(GO:0003938)
2.6 10.2 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
2.4 7.3 GO:0015440 peptide-transporting ATPase activity(GO:0015440)
2.0 6.0 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
2.0 7.9 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
1.8 5.4 GO:0000339 RNA cap binding(GO:0000339)
1.5 1.5 GO:0032296 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
1.3 8.0 GO:0016408 C-acyltransferase activity(GO:0016408)
1.3 5.2 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
1.3 3.9 GO:0072341 modified amino acid binding(GO:0072341)
1.3 6.4 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
1.3 3.8 GO:0004930 G-protein coupled receptor activity(GO:0004930)
1.2 5.0 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
1.2 5.0 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
1.2 3.6 GO:0009922 fatty acid elongase activity(GO:0009922)
1.2 4.7 GO:0016841 ammonia-lyase activity(GO:0016841)
1.1 3.4 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
1.1 3.4 GO:0070568 guanylyltransferase activity(GO:0070568)
1.1 24.7 GO:0019901 protein kinase binding(GO:0019901)
1.0 5.2 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
1.0 4.0 GO:0008297 single-stranded DNA exodeoxyribonuclease activity(GO:0008297) single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
1.0 3.9 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
0.9 7.5 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.9 182.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.8 3.3 GO:0005034 osmosensor activity(GO:0005034)
0.8 3.3 GO:0004771 sterol esterase activity(GO:0004771)
0.8 2.4 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
0.8 3.2 GO:0009378 four-way junction helicase activity(GO:0009378)
0.8 2.4 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.8 4.8 GO:0008143 poly(A) binding(GO:0008143) poly-purine tract binding(GO:0070717)
0.8 1.6 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.8 3.9 GO:0004707 MAP kinase activity(GO:0004707)
0.8 6.8 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.7 2.2 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.7 10.2 GO:0001054 RNA polymerase I activity(GO:0001054)
0.7 2.1 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.7 2.1 GO:0005253 anion channel activity(GO:0005253) voltage-gated anion channel activity(GO:0008308)
0.7 4.2 GO:0003993 acid phosphatase activity(GO:0003993)
0.7 2.7 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.7 2.6 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.6 1.9 GO:0004691 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.6 1.9 GO:0016504 peptidase activator activity(GO:0016504)
0.6 3.1 GO:0070300 phosphatidic acid binding(GO:0070300)
0.6 5.0 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.6 2.5 GO:0042973 glucan endo-1,3-beta-D-glucosidase activity(GO:0042973)
0.6 6.2 GO:0030276 clathrin binding(GO:0030276)
0.6 2.2 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.5 2.7 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.5 3.8 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.5 18.0 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.5 2.6 GO:0008443 phosphofructokinase activity(GO:0008443)
0.5 4.7 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.5 1.5 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.5 3.5 GO:0030145 manganese ion binding(GO:0030145)
0.5 2.5 GO:0070403 NAD+ binding(GO:0070403)
0.5 0.5 GO:0033592 RNA strand annealing activity(GO:0033592) annealing activity(GO:0097617)
0.5 2.0 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.5 9.8 GO:0030515 snoRNA binding(GO:0030515)
0.5 1.4 GO:0008422 beta-glucosidase activity(GO:0008422)
0.5 1.4 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.5 7.6 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.5 1.4 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.5 4.1 GO:0004497 monooxygenase activity(GO:0004497)
0.4 3.6 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.4 1.8 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.4 1.8 GO:0008252 nucleotidase activity(GO:0008252)
0.4 2.6 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.4 1.3 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.4 4.3 GO:0019239 deaminase activity(GO:0019239)
0.4 12.1 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.4 6.3 GO:0003746 translation elongation factor activity(GO:0003746)
0.4 4.3 GO:0015079 potassium ion transmembrane transporter activity(GO:0015079)
0.4 1.9 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.4 0.8 GO:0099516 ion antiporter activity(GO:0099516)
0.4 1.1 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825)
0.4 4.5 GO:0005199 structural constituent of cell wall(GO:0005199)
0.4 1.8 GO:0017048 Rho GTPase binding(GO:0017048)
0.4 1.1 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.4 3.5 GO:0001056 RNA polymerase III activity(GO:0001056)
0.3 1.4 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.3 4.2 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.3 1.0 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
0.3 1.0 GO:0051219 phosphoprotein binding(GO:0051219)
0.3 1.3 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.3 1.0 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.3 11.6 GO:0030674 protein binding, bridging(GO:0030674)
0.3 4.1 GO:0051015 actin filament binding(GO:0051015)
0.3 1.3 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.3 1.3 GO:0008242 omega peptidase activity(GO:0008242)
0.3 5.0 GO:0042803 protein homodimerization activity(GO:0042803)
0.3 1.2 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.3 0.9 GO:0016882 cyclo-ligase activity(GO:0016882)
0.3 0.9 GO:0015188 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.3 4.6 GO:0015926 glucosidase activity(GO:0015926)
0.3 1.8 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.3 2.6 GO:0000009 alpha-1,6-mannosyltransferase activity(GO:0000009)
0.3 1.8 GO:0008312 7S RNA binding(GO:0008312)
0.3 0.8 GO:0008135 translation factor activity, RNA binding(GO:0008135)
0.3 3.0 GO:0070566 adenylyltransferase activity(GO:0070566)
0.3 8.1 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.3 3.7 GO:0001671 ATPase activator activity(GO:0001671)
0.3 1.3 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.3 1.0 GO:0016725 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.3 1.3 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.3 1.3 GO:0008536 Ran GTPase binding(GO:0008536)
0.3 0.8 GO:0000146 microfilament motor activity(GO:0000146)
0.3 3.0 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755) cis-trans isomerase activity(GO:0016859)
0.2 7.7 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.2 1.0 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.2 1.9 GO:0005516 calmodulin binding(GO:0005516)
0.2 3.5 GO:0050661 NADP binding(GO:0050661)
0.2 6.6 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 1.1 GO:0042123 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.2 0.6 GO:0003680 AT DNA binding(GO:0003680)
0.2 11.7 GO:0003924 GTPase activity(GO:0003924)
0.2 1.7 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.2 1.0 GO:0008525 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.2 0.6 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.2 0.8 GO:0055106 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.2 0.4 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.2 0.8 GO:0001055 RNA polymerase II activity(GO:0001055)
0.2 0.8 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.2 0.6 GO:0004326 tetrahydrofolylpolyglutamate synthase activity(GO:0004326)
0.2 0.7 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)
0.2 0.3 GO:0003725 double-stranded RNA binding(GO:0003725)
0.2 1.4 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.2 0.3 GO:0031370 eukaryotic initiation factor 4G binding(GO:0031370)
0.2 2.2 GO:0003714 transcription corepressor activity(GO:0003714)
0.2 1.0 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.2 1.5 GO:0019209 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.2 2.6 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.2 1.0 GO:0019201 nucleotide kinase activity(GO:0019201)
0.2 0.6 GO:0004622 lysophospholipase activity(GO:0004622)
0.2 0.6 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.2 0.9 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.2 0.8 GO:0017108 5'-flap endonuclease activity(GO:0017108) flap endonuclease activity(GO:0048256)
0.2 1.6 GO:0070491 repressing transcription factor binding(GO:0070491)
0.2 1.4 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.2 2.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 0.8 GO:0005496 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.2 0.8 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.1 1.7 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)
0.1 0.6 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 1.4 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.1 0.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 0.8 GO:0001139 transcription factor activity, core RNA polymerase II recruiting(GO:0001139)
0.1 0.3 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 1.1 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 0.5 GO:0001168 transcription factor activity, RNA polymerase I upstream control element sequence-specific binding(GO:0001168)
0.1 0.7 GO:0019237 centromeric DNA binding(GO:0019237)
0.1 4.0 GO:0008237 metallopeptidase activity(GO:0008237)
0.1 0.7 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.1 2.3 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 2.0 GO:0015616 DNA translocase activity(GO:0015616)
0.1 3.6 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 1.0 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 0.5 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.1 2.5 GO:0000030 mannosyltransferase activity(GO:0000030)
0.1 0.1 GO:0005244 voltage-gated ion channel activity(GO:0005244) voltage-gated channel activity(GO:0022832)
0.1 0.3 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity(GO:0034596) phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.1 0.4 GO:0019211 phosphatase activator activity(GO:0019211)
0.1 2.6 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 0.2 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.1 1.7 GO:0008320 protein transmembrane transporter activity(GO:0008320) macromolecule transmembrane transporter activity(GO:0022884)
0.1 3.2 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 0.6 GO:0001005 RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003) transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting(GO:0001004) transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIB recruiting(GO:0001005) transcription factor activity, RNA polymerase III type 2 promoter sequence-specific binding, TFIIIB recruiting(GO:0001008) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034)
0.1 0.3 GO:0004738 pyruvate dehydrogenase activity(GO:0004738)
0.1 1.1 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.1 0.5 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)
0.1 0.3 GO:0016433 rRNA (adenine) methyltransferase activity(GO:0016433)
0.1 1.0 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.1 0.3 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 0.5 GO:0000182 rDNA binding(GO:0000182)
0.1 0.2 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.1 0.2 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.1 0.4 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.1 1.2 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 0.6 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.1 0.3 GO:0000991 transcription factor activity, core RNA polymerase II binding(GO:0000991)
0.1 0.6 GO:0016866 intramolecular transferase activity(GO:0016866)
0.1 2.1 GO:0043130 ubiquitin binding(GO:0043130)
0.1 0.5 GO:0004521 endoribonuclease activity(GO:0004521)
0.1 0.2 GO:0003785 actin monomer binding(GO:0003785)
0.1 0.7 GO:0043175 RNA polymerase core enzyme binding(GO:0043175) RNA polymerase binding(GO:0070063)
0.1 0.6 GO:0033218 signal sequence binding(GO:0005048) amide binding(GO:0033218) peptide binding(GO:0042277)
0.1 0.2 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.2 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 2.1 GO:0008092 cytoskeletal protein binding(GO:0008092)
0.0 0.1 GO:0042736 NAD+ kinase activity(GO:0003951) NADH kinase activity(GO:0042736)
0.0 0.9 GO:0008170 N-methyltransferase activity(GO:0008170)
0.0 0.1 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.0 0.2 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.7 GO:0019001 GTP binding(GO:0005525) guanyl nucleotide binding(GO:0019001) guanyl ribonucleotide binding(GO:0032561)
0.0 0.3 GO:0003724 RNA helicase activity(GO:0003724)
0.0 0.8 GO:0043566 structure-specific DNA binding(GO:0043566)
0.0 1.2 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.2 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.0 0.1 GO:0008169 C-methyltransferase activity(GO:0008169)
0.0 0.9 GO:0042393 histone binding(GO:0042393)
0.0 0.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.2 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.1 GO:0008762 UDP-N-acetylmuramate dehydrogenase activity(GO:0008762)
0.0 0.4 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.1 GO:0019206 nucleoside kinase activity(GO:0019206)
0.0 0.1 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0 0.2 GO:0019207 kinase regulator activity(GO:0019207)
0.0 0.7 GO:0016791 phosphatase activity(GO:0016791)
0.0 0.4 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.1 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.0 0.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.0 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 3.2 GO:0003723 RNA binding(GO:0003723)
0.0 0.1 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.2 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.0 0.8 GO:0008047 enzyme activator activity(GO:0008047)
0.0 0.0 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.0 0.0 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670) oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671) thiol oxidase activity(GO:0016972)
0.0 0.1 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.1 GO:0003774 motor activity(GO:0003774)
0.0 0.0 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 3.2 PID ERBB4 PATHWAY ErbB4 signaling events
1.2 4.7 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
1.0 3.0 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
1.0 3.8 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.9 3.6 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.8 2.3 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.5 2.0 PID FGF PATHWAY FGF signaling pathway
0.4 1.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.3 0.3 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.1 0.4 PID AURORA B PATHWAY Aurora B signaling
0.1 0.2 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.1 0.2 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 0.3 PID MYC PATHWAY C-MYC pathway
0.1 0.1 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 0.3 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.2 PID E2F PATHWAY E2F transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 12.6 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
1.3 20.8 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
1.2 2.5 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
1.2 4.8 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
1.0 3.1 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.9 2.8 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.9 6.2 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.9 3.5 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.8 3.4 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.7 2.2 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.7 5.1 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.5 3.6 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.3 1.4 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.3 0.9 REACTOME SIGNALLING TO ERKS Genes involved in Signalling to ERKs
0.3 1.1 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.2 1.3 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.2 0.4 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.2 0.2 REACTOME SIGNALING BY THE B CELL RECEPTOR BCR Genes involved in Signaling by the B Cell Receptor (BCR)
0.2 0.7 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.2 1.1 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 1.5 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 1.1 REACTOME RNA POL II PRE TRANSCRIPTION EVENTS Genes involved in RNA Polymerase II Pre-transcription Events
0.1 0.2 REACTOME SIGNALING BY ERBB4 Genes involved in Signaling by ERBB4
0.1 0.2 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.1 0.5 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 0.1 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 0.3 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.1 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination