Results for HCM1
Z-value: 2.45
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Transcription factors associated with HCM1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
HCM1
|
S000000661 | Forkhead transcription factor |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YPR119W Show fit | 44.36 |
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome |
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| YER124C Show fit | 38.40 |
Daughter cell-specific protein, may participate in pathways regulating cell wall metabolism; deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall |
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| YGR108W Show fit | 33.87 |
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome |
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| YFR055W Show fit | 32.72 |
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner |
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| YJR094W-A Show fit | 30.98 |
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein |
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| YOR315W Show fit | 30.77 |
Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate |
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| YFR056C Show fit | 28.60 |
Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W |
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| YDR033W Show fit | 23.50 |
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p |
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| YLL045C Show fit | 20.40 |
Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits |
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| YKR092C Show fit | 18.56 |
Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HCM1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 306.5 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 7.5 | 82.4 | GO:0007109 | obsolete cytokinesis, completion of separation(GO:0007109) |
| 11.6 | 81.2 | GO:0010696 | positive regulation of spindle pole body separation(GO:0010696) |
| 0.5 | 46.5 | GO:0051169 | nucleocytoplasmic transport(GO:0006913) nuclear transport(GO:0051169) |
| 2.3 | 36.6 | GO:0051029 | rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029) |
| 10.9 | 32.7 | GO:0000098 | sulfur amino acid catabolic process(GO:0000098) |
| 2.2 | 31.2 | GO:0000921 | septin ring assembly(GO:0000921) |
| 0.6 | 26.9 | GO:0007124 | pseudohyphal growth(GO:0007124) |
| 1.0 | 24.9 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184) |
| 1.2 | 24.6 | GO:0006334 | nucleosome assembly(GO:0006334) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 210.6 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 1.0 | 183.5 | GO:0005933 | cellular bud(GO:0005933) |
| 2.4 | 146.7 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 5.0 | 59.9 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.1 | 33.8 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 1.9 | 32.2 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.6 | 22.6 | GO:0030659 | vesicle membrane(GO:0012506) cytoplasmic vesicle membrane(GO:0030659) |
| 5.5 | 21.9 | GO:0032160 | septin filament array(GO:0032160) |
| 0.2 | 20.2 | GO:0005730 | nucleolus(GO:0005730) |
| 0.5 | 19.4 | GO:0005811 | lipid particle(GO:0005811) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 325.7 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 3.3 | 85.1 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 1.9 | 60.4 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.5 | 33.7 | GO:0003924 | GTPase activity(GO:0003924) |
| 2.9 | 26.3 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 1.1 | 23.6 | GO:0042162 | telomeric DNA binding(GO:0042162) |
| 0.6 | 21.8 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
| 0.7 | 21.6 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 3.4 | 20.3 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 1.3 | 20.0 | GO:0015926 | glucosidase activity(GO:0015926) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 9.2 | PID ATR PATHWAY | ATR signaling pathway |
| 1.5 | 6.0 | PID E2F PATHWAY | E2F transcription factor network |
| 1.2 | 4.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 1.6 | 4.7 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 1.1 | 4.2 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 1.2 | 3.6 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.9 | 3.6 | PID FGF PATHWAY | FGF signaling pathway |
| 0.7 | 3.4 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.7 | 2.1 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.9 | 1.8 | PID AURORA B PATHWAY | Aurora B signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 53.2 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 4.6 | 37.0 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 2.1 | 8.2 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 1.5 | 7.6 | REACTOME GPCR LIGAND BINDING | Genes involved in GPCR ligand binding |
| 1.1 | 6.6 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.8 | 5.8 | REACTOME DEADENYLATION DEPENDENT MRNA DECAY | Genes involved in Deadenylation-dependent mRNA decay |
| 0.6 | 5.6 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 1.8 | 5.3 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 1.3 | 5.3 | REACTOME GLOBAL GENOMIC NER GG NER | Genes involved in Global Genomic NER (GG-NER) |
| 2.1 | 4.2 | REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |