Results for HCM1

Z-value: 2.45

Motif logo

Transcription factors associated with HCM1

Gene Symbol Gene ID Gene Info
S000000661 Forkhead transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of HCM1 motif

Sorted Z-values of HCM1 motif

Promoter Log-likelihood Transcript Gene Gene Info
YPR119W 44.36 B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YER124C 38.40 Daughter cell-specific protein, may participate in pathways regulating cell wall metabolism; deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall
YGR108W 33.87 B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YFR055W 32.72 Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YJR094W-A 30.98 Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YOR315W 30.77 Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
YFR056C 28.60 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YDR033W 23.50 Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YLL045C 20.40 Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits
YKR092C 18.56 Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YLR042C 17.14 Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene
YNR001W-A 16.60 Dubious open reading frame unlikely to encode a functional protein; identified by homology
YDL055C 16.58 GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YBR158W 15.57 Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YBR009C 14.36 One of two identical histone H4 proteins (see also HHF2); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
YLR372W 13.91 Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis
YOL127W 13.74 Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 26S rRNA via a conserved C-terminal motif
YLR314C 13.19 Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YDL211C 12.36 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YOR314W 11.89 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNR009W 11.79 Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase
YGL028C 11.66 Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p
YGL225W 11.52 Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi
YLR286C 11.49 Endochitinase, required for cell separation after mitosis; transcriptional activation during late G and early M cell cycle phases is mediated by transcription factor Ace2p
YLR257W 11.26 Putative protein of unknown function
YHL028W 11.15 ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3
YHR094C 11.04 Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YBR011C 10.84 Cytoplasmic inorganic pyrophosphatase (PPase), catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase
YER070W 10.76 One of two large regulatory subunits of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits
YIR021W 10.75 Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YGL102C 10.43 Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein
YOR313C 10.41 Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage
YGL021W 10.41 Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk2p and to mammalian haspins
YCR018C 10.35 Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YPL177C 10.17 Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription
YNL178W 10.10 Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YKL122C 10.06 Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
YGR040W 10.05 Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
YOR051C 9.73 Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
YDR224C 9.64 One of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
YFR032C-A 9.64 Protein component of the large (60S) ribosomal subunit, has similarity to rat L29 ribosomal protein; not essential for translation, but required for proper joining of the large and small ribosomal subunits and for normal translation rate
YGL039W 9.57 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YMR106C 9.50 Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
YJR145C 9.48 Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein
YBR010W 9.43 One of two identical histone H3 proteins (see also HHT2); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation
YDR225W 9.11 One of two nearly identical (see also HTA2) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
YDL084W 9.10 Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56
YGL209W 9.06 Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter
YJL136C 9.05 Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Ap and has similarity to rat S21 ribosomal protein
YHR181W 9.04 Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YDR345C 8.94 Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YHR143W 8.80 Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP
YJL158C 8.63 Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
YLR325C 8.40 Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein
YMR003W 8.31 Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YKR079C 8.28 tRNase Z, involved in RNA processing, has two putative nucleotide triphosphate-binding motifs (P-loop) and a conserved histidine motif, homolog of the human candidate prostate cancer susceptibility gene ELAC2
YNL066W 8.25 Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family
YMR290C 8.14 ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YAL038W 8.10 Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration
YMR290W-A 8.07 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YGR138C 8.04 Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
YKL153W 8.04 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant
YLR300W 7.95 Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes
YBL092W 7.94 Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing
YGR106C 7.87 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane
YDR098C 7.84 Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YMR072W 7.83 Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
YBR181C 7.75 Protein component of the small (40S) ribosomal subunit; identical to Rps6Ap and has similarity to rat S6 ribosomal protein
YGR148C 7.75 Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YKL096W-A 7.73 Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YBR112C 7.73 General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters
YPL108W 7.67 Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YGL101W 7.64 Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p
YML088W 7.56 F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation
YDR146C 7.54 Transcription factor that activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase
YLR167W 7.50 Fusion protein that is cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B
YOR222W 7.48 Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism
YFR054C 7.46 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL327W 7.45 Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner
YFL015W-A 7.36 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR417C 7.31 Hypothetical protein
YJR009C 7.25 Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
YBL031W 7.23 Cytoskeletal protein of unknown function; overexpression causes growth arrest
YNL030W 7.21 One of two identical histone H4 proteins (see also HHF1); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
YFL015C 7.13 Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
YOR312C 7.12 Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Ap and has similarity to rat L18a ribosomal protein
YOL124C 7.10 Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
YGR251W 7.07 Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YMR144W 7.04 Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene
YLR328W 7.04 Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways
YML124C 6.97 Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p
YHL015W 6.97 Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; has similarity to E. coli S10 and rat S20 ribosomal proteins
YLR301W 6.97 Protein of unknown function that interacts with Sec72p
YER177W 6.96 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
YOL056W 6.93 Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
YPL250W-A 6.89 Identified by fungal homology and RT-PCR
YOR369C 6.87 Protein component of the small (40S) ribosomal subunit; has similarity to rat ribosomal protein S12
YKR093W 6.85 Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
YJL177W 6.71 Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Ap and has similarity to E. coli L22 and rat L17 ribosomal proteins
YMR199W 6.68 G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YBR092C 6.67 Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin
YPR157W 6.64 Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YDR002W 6.62 Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1
YGR214W 6.60 Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YMR083W 6.58 Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YIL158W 6.58 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YDR044W 6.55 Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YIL131C 6.51 Forkhead family transcription factor with a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; regulates donor preference during switching
YGL040C 6.50 Delta-aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen, the second step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus
YOR050C 6.50 Hypothetical protein
YMR281W 6.49 ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp
YNL111C 6.46 Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
YGR107W 6.43 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR333C 6.40 Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Ap and has similarity to rat S25 ribosomal protein
YBR113W 6.39 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8
YHR005C-A 6.39 Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that mediates insertion of hydrophobic proteins at the inner membrane, has homology to Mrs5p, which is also involved in this process
YHR180W-A 6.37 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3
YGR195W 6.36 3'-to-5' phosphorolytic exoribonuclease that is a subunit of the exosome; required for 3' processing of the 5.8S rRNA; involved in 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs
YGL009C 6.35 Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway
YLR190W 6.33 Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p
YPR148C 6.32 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YLR206W 6.31 Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
YGR140W 6.31 Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo
YEL040W 6.30 Cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; putative chitin transglycosidase; glycosylphosphatidylinositol (GPI)-anchored protein localized to the bud neck; has a role in cell wall maintenance
YGR264C 6.30 Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs
YGL179C 6.29 Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YDL191W 6.28 Protein component of the large (60S) ribosomal subunit, identical to Rpl35Bp and has similarity to rat L35 ribosomal protein
YDL101C 6.28 Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair
YBR249C 6.23 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan
YNL043C 6.22 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
YNL090W 6.22 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly
YNR018W 6.19 Putative protein of unknown function; non-tagged protein is detected in purified mitochondria; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YPL141C 6.13 Putative protein kinase; similar to Kin4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL141C is not an essential gene
YJL190C 6.10 Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Bp and has similarity to E. coli S8 and rat S15a ribosomal proteins
YLR413W 6.10 Putative protein of unknown function; YLR413W is not an essential gene
YKR038C 6.10 Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex
YER137C 6.09 Putative protein of unknown function
YGL158W 6.06 Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations
YGR265W 6.04 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase
YOR011W 6.03 Transporter of the ATP-binding cassette family, involved in uptake of sterols and anaerobic growth
YER117W 6.02 Protein component of the large (60S) ribosomal subunit, identical to Rpl23Ap and has similarity to E. coli L14 and rat L23 ribosomal proteins
YDR279W 6.00 Ribonuclease H2 subunit, required for RNase H2 activity
YHR108W 5.98 Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi
YDL228C 5.92 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene SSB1
YLR411W 5.87 High-affinity copper transporter of the plasma membrane, acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae
YLR154C 5.84 Ribonuclease H2 subunit, required for RNase H2 activity
YOL155C 5.80 Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines
YNR016C 5.76 Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids
YML063W 5.74 Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Ap and has similarity to rat S3a ribosomal protein
YOL015W 5.74 Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci
YLR109W 5.66 Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p
YOL088C 5.65 Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p
YLR180W 5.60 S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YLR060W 5.52 Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; sequence is evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase (Msf1p), but substrate binding is similar
YNL035C 5.51 Putative protein of unknown function with similarity to proteins containing WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene
YGR139W 5.48 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR061W 5.46 Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Bp and to rat L22 ribosomal protein
YAL033W 5.40 Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YKL209C 5.39 Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells
YMR307W 5.32 Beta-1,3-glucanosyltransferase, required for cell wall assembly; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor
YER043C 5.32 S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
YDL003W 5.30 Essential protein required for sister chromatid cohesion in mitosis and meiosis; subunit of the cohesin complex; expression is cell cycle regulated and peaks in S phase
YBL063W 5.24 Kinesin-related motor protein required for mitotic spindle assembly and chromosome segregation; functionally redundant with Cin8p
YCR004C 5.20 Protein of unknown function, has sequence and structural similarity to flavodoxins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YCR043C 5.19 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene
YMR032W 5.18 Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p
YBR087W 5.16 Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
YIL009W 5.16 Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YCR099C 5.15 Putative protein of unknown function
YLR083C 5.15 Protein with a role in cellular adhesion and filamentous growth; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments; 24kDa cleavage product found in endosome-enriched membrane fractions
YAR002W 5.12 Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP; potential Cdc28p substrate; involved in telomere maintenance
YGR085C 5.12 Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11
YOR277C 5.09 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20
YOR029W 5.06 Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YDL192W 4.96 ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; functionally interchangeable with Arf2p
YDL241W 4.94 Putative protein of unknown function; YDL241W is not an essential gene
YDR346C 4.94 Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis
YJL011C 4.90 RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex
YLR154W-A 4.89 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YLR154W-B 4.89 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YOL002C 4.88 Plasma membrane protein involved in zinc metabolism and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
YKL164C 4.83 O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle
YBR012C 4.83 Dubious open reading frame, unlikely to encode a functional protein; expression induced by iron-regulated transcriptional activator Aft2p
YPL142C 4.82 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit
YEL053W-A 4.81 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YEL054C
YOR247W 4.78 Mannoprotein that exhibits a tight association with the cell wall, required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants
YDR344C 4.78 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR008C-A 4.77 Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres
YER011W 4.73 Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking
YMR202W 4.72 C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis
YOL005C 4.71 RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit
YNL024C 4.70 Putative protein of unknown function with seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL024C is not an essential gene
YOL041C 4.70 Nucleolar protein, required for pre-25S rRNA processing; contains an RNA recognition motif (RRM) and has similarity to Nop13p, Nsr1p, and putative orthologs in Drosophila and S. pombe
YOL115W 4.68 Catalytic subunit of TRAMP (Trf4/Pap2p-Mtr4p-Air1p/2p), a nuclear poly (A) polymerase complex involved in RNA quality control; catalyzes polyadenylation of unmodified tRNAs, and snoRNA and rRNA precursors; disputed role as a DNA polymerase
YKR013W 4.67 Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins
YCR006C 4.67 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR353W 4.64 Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
YCR084C 4.62 General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes
YCL018W 4.61 Beta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis pathway
YJR022W 4.60 Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA

Network of associatons between targets according to the STRING database.

First level regulatory network of HCM1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
11.6 81.2 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
10.9 32.7 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
7.5 22.5 GO:0035952 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
7.5 82.4 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
5.5 16.6 GO:0009298 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
4.5 22.5 GO:0060277 obsolete negative regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0060277)
4.4 17.7 GO:0030497 fatty acid elongation(GO:0030497)
4.2 17.0 GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000461)
3.8 11.4 GO:0051439 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
3.7 14.8 GO:0000296 spermine transport(GO:0000296)
2.9 20.6 GO:0034729 histone H3-K79 methylation(GO:0034729)
2.7 8.2 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
2.6 10.4 GO:0007535 donor selection(GO:0007535)
2.5 2.5 GO:0046898 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
2.5 7.4 GO:0000092 mitotic anaphase B(GO:0000092)
2.4 11.8 GO:0015780 nucleotide-sugar transport(GO:0015780)
2.3 36.6 GO:0051029 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
2.3 13.6 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
2.2 11.2 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
2.2 31.2 GO:0000921 septin ring assembly(GO:0000921)
2.2 306.5 GO:0002181 cytoplasmic translation(GO:0002181)
2.1 6.4 GO:0034473 U1 snRNA 3'-end processing(GO:0034473)
2.1 10.6 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
2.0 14.0 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
2.0 13.9 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
2.0 19.6 GO:0009262 deoxyribonucleotide metabolic process(GO:0009262) deoxyribonucleotide biosynthetic process(GO:0009263)
1.9 7.5 GO:0045896 regulation of transcription during mitosis(GO:0045896)
1.8 9.2 GO:0045338 terpenoid metabolic process(GO:0006721) terpenoid biosynthetic process(GO:0016114) farnesyl diphosphate biosynthetic process(GO:0045337) farnesyl diphosphate metabolic process(GO:0045338)
1.8 9.1 GO:0051597 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
1.8 14.4 GO:0000743 nuclear migration involved in conjugation with cellular fusion(GO:0000743)
1.8 9.0 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
1.8 5.3 GO:0090220 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
1.8 3.6 GO:0015909 long-chain fatty acid transport(GO:0015909)
1.8 3.5 GO:0034724 DNA replication-independent nucleosome organization(GO:0034724)
1.8 5.3 GO:0008334 histone mRNA metabolic process(GO:0008334) histone mRNA catabolic process(GO:0071044)
1.7 8.5 GO:0042780 tRNA 3'-end processing(GO:0042780)
1.7 6.8 GO:0009423 chorismate biosynthetic process(GO:0009423)
1.6 3.3 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
1.6 4.9 GO:0048194 Golgi vesicle budding(GO:0048194)
1.6 1.6 GO:0097271 protein localization to bud neck(GO:0097271)
1.6 1.6 GO:0001015 snoRNA transcription from an RNA polymerase II promoter(GO:0001015)
1.6 9.5 GO:0090158 regulation of phosphatidylinositol dephosphorylation(GO:0060304) endoplasmic reticulum membrane organization(GO:0090158)
1.6 7.8 GO:0006177 GMP biosynthetic process(GO:0006177)
1.5 4.6 GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)(GO:0019379) sulfate reduction(GO:0019419)
1.5 3.0 GO:0099515 actin filament-based movement(GO:0030048) actin filament-based transport(GO:0099515)
1.5 5.9 GO:0060188 regulation of protein desumoylation(GO:0060188)
1.4 4.3 GO:0043171 peptide catabolic process(GO:0043171)
1.4 4.3 GO:0000916 actomyosin contractile ring contraction(GO:0000916) contractile ring contraction(GO:0036213)
1.4 21.5 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082)
1.4 1.4 GO:0032368 regulation of lipid transport(GO:0032368)
1.4 5.6 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
1.4 1.4 GO:1901352 regulation of phosphatidylglycerol biosynthetic process(GO:1901351) negative regulation of phosphatidylglycerol biosynthetic process(GO:1901352)
1.4 8.3 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
1.3 13.3 GO:0006116 NADH oxidation(GO:0006116)
1.3 10.6 GO:0000376 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
1.3 6.6 GO:0035376 sterol import(GO:0035376)
1.3 9.2 GO:0032042 mitochondrial DNA metabolic process(GO:0032042)
1.3 16.9 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
1.3 6.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
1.3 5.0 GO:0006528 asparagine metabolic process(GO:0006528)
1.2 24.6 GO:0006334 nucleosome assembly(GO:0006334)
1.2 11.1 GO:0000433 negative regulation of transcription from RNA polymerase II promoter by glucose(GO:0000433) negative regulation of transcription by glucose(GO:0045014)
1.2 3.6 GO:0071825 lipid tube assembly(GO:0060988) protein-lipid complex assembly(GO:0065005) protein-lipid complex subunit organization(GO:0071825)
1.2 2.4 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
1.2 2.4 GO:0072361 regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361) regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072363)
1.2 5.9 GO:0032231 regulation of actin filament bundle assembly(GO:0032231) positive regulation of actin filament bundle assembly(GO:0032233)
1.2 3.6 GO:0051607 immune effector process(GO:0002252) immune system process(GO:0002376) response to virus(GO:0009615) response to external biotic stimulus(GO:0043207) defense response to virus(GO:0051607) response to other organism(GO:0051707) defense response to other organism(GO:0098542)
1.2 2.3 GO:0006567 threonine catabolic process(GO:0006567)
1.2 3.5 GO:0042710 biofilm formation(GO:0042710)
1.1 13.4 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
1.1 3.3 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
1.1 6.6 GO:0000022 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231)
1.1 9.8 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
1.1 6.5 GO:0048478 replication fork protection(GO:0048478)
1.0 2.1 GO:0090502 endonucleolytic cleavage involved in rRNA processing(GO:0000478) endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000479) RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
1.0 3.1 GO:1901985 positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
1.0 3.1 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
1.0 4.1 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
1.0 2.0 GO:0033262 regulation of nuclear cell cycle DNA replication(GO:0033262)
1.0 5.0 GO:0006491 N-glycan processing(GO:0006491)
1.0 24.9 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
1.0 2.9 GO:0046831 regulation of mRNA export from nucleus(GO:0010793) regulation of nucleobase-containing compound transport(GO:0032239) regulation of RNA export from nucleus(GO:0046831) regulation of ribonucleoprotein complex localization(GO:2000197)
1.0 5.9 GO:0042538 hyperosmotic salinity response(GO:0042538)
1.0 2.9 GO:0070475 rRNA base methylation(GO:0070475)
1.0 2.9 GO:0015867 ATP transport(GO:0015867)
1.0 16.2 GO:0030488 tRNA methylation(GO:0030488)
0.9 4.6 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.9 2.8 GO:1900101 regulation of endoplasmic reticulum unfolded protein response(GO:1900101)
0.9 2.7 GO:0043066 negative regulation of apoptotic process(GO:0043066) negative regulation of programmed cell death(GO:0043069) negative regulation of cell death(GO:0060548)
0.9 9.9 GO:0000917 barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529)
0.9 7.2 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.9 2.7 GO:0006571 tyrosine biosynthetic process(GO:0006571)
0.9 2.6 GO:0010922 positive regulation of phosphatase activity(GO:0010922)
0.9 12.2 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.9 2.6 GO:0006021 inositol biosynthetic process(GO:0006021)
0.9 8.7 GO:0007021 tubulin complex assembly(GO:0007021)
0.9 2.6 GO:0046855 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
0.9 2.6 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.9 1.7 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.9 3.4 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.8 0.8 GO:0034402 recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex(GO:0034402)
0.8 3.3 GO:0042938 dipeptide transport(GO:0042938)
0.8 20.5 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.8 11.4 GO:0008298 intracellular mRNA localization(GO:0008298)
0.8 7.3 GO:0051320 mitotic S phase(GO:0000084) S phase(GO:0051320)
0.8 8.9 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.8 2.4 GO:0031384 regulation of initiation of mating projection growth(GO:0031384)
0.8 16.9 GO:0012501 apoptotic process(GO:0006915) cell death(GO:0008219) programmed cell death(GO:0012501)
0.8 3.2 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.8 2.4 GO:0051664 nuclear pore distribution(GO:0031081) nuclear pore localization(GO:0051664)
0.8 7.1 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.8 1.6 GO:0015680 intracellular copper ion transport(GO:0015680)
0.8 2.3 GO:0035459 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.8 8.5 GO:0033967 box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963)
0.8 17.6 GO:0006885 regulation of pH(GO:0006885)
0.8 5.4 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.8 1.5 GO:0006657 CDP-choline pathway(GO:0006657)
0.8 18.2 GO:0044108 ergosterol biosynthetic process(GO:0006696) phytosteroid biosynthetic process(GO:0016129) cellular alcohol biosynthetic process(GO:0044108) cellular lipid biosynthetic process(GO:0097384)
0.8 1.5 GO:0006048 UDP-N-acetylglucosamine metabolic process(GO:0006047) UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.7 7.5 GO:0006272 leading strand elongation(GO:0006272)
0.7 1.5 GO:0010695 regulation of spindle pole body separation(GO:0010695)
0.7 2.2 GO:0023021 termination of signal transduction(GO:0023021) termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.7 5.2 GO:0030705 cytoskeleton-dependent intracellular transport(GO:0030705)
0.7 9.4 GO:0010383 cell wall polysaccharide metabolic process(GO:0010383)
0.7 3.6 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.7 1.4 GO:0010674 negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010674)
0.7 1.4 GO:0042990 regulation of transcription factor import into nucleus(GO:0042990) negative regulation of transcription factor import into nucleus(GO:0042992)
0.7 4.9 GO:0030011 maintenance of cell polarity(GO:0030011)
0.7 4.2 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.7 4.0 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.7 3.3 GO:0035392 maintenance of chromatin silencing(GO:0006344) maintenance of chromatin silencing at telomere(GO:0035392)
0.6 7.7 GO:0009636 response to toxic substance(GO:0009636)
0.6 9.4 GO:0042797 tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.6 3.7 GO:1901658 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.6 3.1 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.6 4.3 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.6 3.0 GO:0043102 L-methionine biosynthetic process from methylthioadenosine(GO:0019509) amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
0.6 2.4 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
0.6 3.6 GO:0006448 regulation of translational elongation(GO:0006448)
0.6 26.9 GO:0007124 pseudohyphal growth(GO:0007124)
0.6 5.2 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.6 0.6 GO:0032886 regulation of microtubule-based process(GO:0032886) regulation of microtubule cytoskeleton organization(GO:0070507)
0.6 0.6 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
0.6 3.4 GO:0072337 modified amino acid transport(GO:0072337)
0.6 3.4 GO:0015833 peptide transport(GO:0015833)
0.6 1.1 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.6 6.1 GO:0009435 NAD biosynthetic process(GO:0009435)
0.6 8.3 GO:0032986 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.5 2.6 GO:0000173 inactivation of MAPK activity involved in osmosensory signaling pathway(GO:0000173)
0.5 3.7 GO:0051666 actin cortical patch localization(GO:0051666)
0.5 5.7 GO:0032508 DNA duplex unwinding(GO:0032508)
0.5 2.6 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.5 8.6 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.5 11.7 GO:0045047 protein targeting to ER(GO:0045047)
0.5 4.0 GO:0006415 translational termination(GO:0006415)
0.5 3.9 GO:0007120 axial cellular bud site selection(GO:0007120)
0.5 2.5 GO:0042558 folic acid-containing compound metabolic process(GO:0006760) folic acid-containing compound biosynthetic process(GO:0009396) pteridine-containing compound metabolic process(GO:0042558) pteridine-containing compound biosynthetic process(GO:0042559)
0.5 1.0 GO:0006636 unsaturated fatty acid biosynthetic process(GO:0006636) unsaturated fatty acid metabolic process(GO:0033559)
0.5 2.9 GO:1903338 regulation of cell wall organization or biogenesis(GO:1903338)
0.5 6.8 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.5 1.0 GO:0009847 spore germination(GO:0009847)
0.5 1.9 GO:0000771 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.5 5.7 GO:0044396 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.5 1.4 GO:0007232 osmosensory signaling pathway via Sho1 osmosensor(GO:0007232)
0.5 10.4 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.5 4.2 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.5 5.1 GO:0006446 regulation of translational initiation(GO:0006446)
0.5 6.9 GO:0006730 one-carbon metabolic process(GO:0006730)
0.5 1.4 GO:0034389 lipid particle organization(GO:0034389)
0.5 2.3 GO:0009147 CTP biosynthetic process(GO:0006241) pyrimidine nucleoside triphosphate metabolic process(GO:0009147) pyrimidine ribonucleoside triphosphate metabolic process(GO:0009208) pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209) CTP metabolic process(GO:0046036)
0.5 5.5 GO:1902299 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.5 46.5 GO:0051169 nucleocytoplasmic transport(GO:0006913) nuclear transport(GO:0051169)
0.5 1.4 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.5 12.6 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.4 1.3 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.4 13.2 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.4 6.6 GO:0000001 mitochondrion inheritance(GO:0000001) mitochondrion distribution(GO:0048311)
0.4 3.5 GO:0006797 polyphosphate metabolic process(GO:0006797)
0.4 1.3 GO:0030031 cell projection organization(GO:0030030) cell projection assembly(GO:0030031)
0.4 2.2 GO:0030847 termination of RNA polymerase II transcription, exosome-dependent(GO:0030847)
0.4 2.2 GO:0046219 tryptophan biosynthetic process(GO:0000162) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
0.4 1.3 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.4 3.1 GO:0070058 tRNA gene clustering(GO:0070058)
0.4 2.6 GO:0000011 vacuole inheritance(GO:0000011)
0.4 11.3 GO:0000910 cytokinesis(GO:0000910)
0.4 0.4 GO:0031590 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.4 0.4 GO:0016094 polyprenol metabolic process(GO:0016093) polyprenol biosynthetic process(GO:0016094) dolichol metabolic process(GO:0019348) dolichol biosynthetic process(GO:0019408)
0.4 1.3 GO:0051016 regulation of actin filament depolymerization(GO:0030834) negative regulation of actin filament depolymerization(GO:0030835) negative regulation of protein complex disassembly(GO:0043242) barbed-end actin filament capping(GO:0051016) actin filament capping(GO:0051693) regulation of protein depolymerization(GO:1901879) negative regulation of protein depolymerization(GO:1901880)
0.4 2.5 GO:0006563 L-serine metabolic process(GO:0006563)
0.4 24.4 GO:0008033 tRNA processing(GO:0008033)
0.4 0.8 GO:0006998 nuclear envelope organization(GO:0006998)
0.4 4.5 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.4 1.6 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
0.4 3.2 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.4 0.8 GO:0034059 response to anoxia(GO:0034059) cellular response to anoxia(GO:0071454)
0.4 1.6 GO:0009088 threonine biosynthetic process(GO:0009088)
0.4 1.2 GO:0015740 C4-dicarboxylate transport(GO:0015740)
0.4 1.2 GO:0006353 DNA-templated transcription, termination(GO:0006353)
0.4 2.3 GO:0000742 karyogamy involved in conjugation with cellular fusion(GO:0000742)
0.4 0.8 GO:0032262 pyrimidine ribonucleotide salvage(GO:0010138) pyrimidine nucleotide salvage(GO:0032262) pyrimidine nucleoside salvage(GO:0043097) UMP salvage(GO:0044206)
0.4 0.4 GO:0035337 fatty-acyl-CoA metabolic process(GO:0035337)
0.4 2.3 GO:0006672 ceramide metabolic process(GO:0006672) ceramide biosynthetic process(GO:0046513)
0.4 2.2 GO:0016559 peroxisome fission(GO:0016559)
0.4 2.6 GO:0006874 cellular calcium ion homeostasis(GO:0006874) calcium ion homeostasis(GO:0055074)
0.4 1.4 GO:0043007 maintenance of rDNA(GO:0043007)
0.4 1.8 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.4 16.8 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.4 3.2 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.4 0.4 GO:0046470 phosphatidylcholine metabolic process(GO:0046470)
0.3 4.2 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.3 1.7 GO:0070941 eisosome assembly(GO:0070941)
0.3 1.0 GO:0009371 positive regulation of transcription from RNA polymerase II promoter by pheromones(GO:0007329) positive regulation of transcription by pheromones(GO:0009371)
0.3 5.8 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.3 1.7 GO:0045116 protein neddylation(GO:0045116)
0.3 0.3 GO:0070827 chromatin maintenance(GO:0070827)
0.3 1.6 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.3 0.3 GO:0070868 heterochromatin organization involved in chromatin silencing(GO:0070868) chromatin organization involved in negative regulation of transcription(GO:0097549)
0.3 1.0 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.3 2.1 GO:0033313 meiotic cell cycle checkpoint(GO:0033313) meiotic recombination checkpoint(GO:0051598)
0.3 1.2 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.3 3.5 GO:0018022 peptidyl-lysine methylation(GO:0018022)
0.3 0.6 GO:0042256 mature ribosome assembly(GO:0042256)
0.3 2.6 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.3 0.9 GO:0006007 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
0.3 2.0 GO:0015791 polyol transport(GO:0015791)
0.3 5.4 GO:0007015 actin filament organization(GO:0007015)
0.3 1.1 GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay(GO:0070481)
0.3 0.5 GO:0051443 positive regulation of protein ubiquitination(GO:0031398) positive regulation of mitotic nuclear division(GO:0045840) positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of ligase activity(GO:0051351) positive regulation of ubiquitin-protein transferase activity(GO:0051443) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101) positive regulation of protein modification by small protein conjugation or removal(GO:1903322) positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.3 0.3 GO:0071478 cellular response to radiation(GO:0071478) cellular response to light stimulus(GO:0071482)
0.3 1.3 GO:0022615 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.3 0.3 GO:0006531 aspartate metabolic process(GO:0006531)
0.3 1.0 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.3 1.3 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.3 4.3 GO:0030036 actin cytoskeleton organization(GO:0030036)
0.2 0.7 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity(GO:0051090)
0.2 1.9 GO:0015939 pantothenate metabolic process(GO:0015939) pantothenate biosynthetic process(GO:0015940)
0.2 5.1 GO:0009179 purine nucleoside diphosphate metabolic process(GO:0009135) purine ribonucleoside diphosphate metabolic process(GO:0009179) ribonucleoside diphosphate metabolic process(GO:0009185) ADP metabolic process(GO:0046031)
0.2 1.4 GO:0006694 steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126)
0.2 0.7 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.2 1.8 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.2 0.9 GO:0036260 7-methylguanosine RNA capping(GO:0009452) RNA capping(GO:0036260)
0.2 0.2 GO:0048211 Golgi vesicle docking(GO:0048211)
0.2 0.6 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.2 6.2 GO:0016311 dephosphorylation(GO:0016311)
0.2 3.6 GO:0042255 ribosome assembly(GO:0042255)
0.2 0.2 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.2 0.4 GO:0051984 positive regulation of sister chromatid cohesion(GO:0045876) positive regulation of chromosome segregation(GO:0051984)
0.2 0.4 GO:0006734 NADH metabolic process(GO:0006734)
0.2 0.8 GO:0009306 protein secretion(GO:0009306)
0.2 1.4 GO:0016233 telomere capping(GO:0016233)
0.2 2.2 GO:0007052 mitotic spindle organization(GO:0007052)
0.2 2.0 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.2 0.8 GO:0016574 histone ubiquitination(GO:0016574)
0.2 0.6 GO:0007030 Golgi organization(GO:0007030)
0.2 0.4 GO:0034032 coenzyme A metabolic process(GO:0015936) nucleoside bisphosphate metabolic process(GO:0033865) ribonucleoside bisphosphate metabolic process(GO:0033875) purine nucleoside bisphosphate metabolic process(GO:0034032)
0.2 1.2 GO:0007323 peptide pheromone maturation(GO:0007323)
0.2 1.4 GO:0052803 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.2 0.3 GO:0044036 cell wall macromolecule metabolic process(GO:0044036)
0.2 3.3 GO:0009247 GPI anchor biosynthetic process(GO:0006506) glycolipid biosynthetic process(GO:0009247)
0.2 2.2 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.2 0.2 GO:0033239 negative regulation of cellular amine metabolic process(GO:0033239)
0.2 0.9 GO:0008202 steroid metabolic process(GO:0008202) sterol metabolic process(GO:0016125)
0.1 0.3 GO:0001109 promoter clearance during DNA-templated transcription(GO:0001109) promoter clearance from RNA polymerase II promoter(GO:0001111)
0.1 0.4 GO:0044070 regulation of anion transport(GO:0044070)
0.1 0.7 GO:0005992 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.1 3.5 GO:0006413 translational initiation(GO:0006413)
0.1 0.3 GO:0032006 regulation of TOR signaling(GO:0032006)
0.1 0.4 GO:0031047 gene silencing involved in chronological cell aging(GO:0010978) gene silencing by RNA(GO:0031047)
0.1 0.8 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.1 0.4 GO:0006972 hyperosmotic response(GO:0006972)
0.1 0.4 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.1 0.4 GO:0007234 osmosensory signaling via phosphorelay pathway(GO:0007234)
0.1 1.1 GO:0090151 establishment of protein localization to mitochondrial membrane(GO:0090151)
0.1 5.7 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.1 0.1 GO:0016578 histone deubiquitination(GO:0016578)
0.1 1.3 GO:0018208 protein peptidyl-prolyl isomerization(GO:0000413) peptidyl-proline modification(GO:0018208)
0.1 0.3 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1 1.0 GO:0034620 endoplasmic reticulum unfolded protein response(GO:0030968) cellular response to unfolded protein(GO:0034620) cellular response to topologically incorrect protein(GO:0035967)
0.1 1.9 GO:0006893 Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.1 0.4 GO:0000348 mRNA branch site recognition(GO:0000348)
0.1 0.5 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.1 0.7 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.1 0.3 GO:0051647 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023) nucleus localization(GO:0051647)
0.1 0.3 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.1 0.7 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.1 0.2 GO:0043471 regulation of carbohydrate catabolic process(GO:0043470) regulation of cellular carbohydrate catabolic process(GO:0043471)
0.1 0.1 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
0.1 0.2 GO:0006816 calcium ion transport(GO:0006816)
0.1 0.4 GO:0018202 peptidyl-histidine modification(GO:0018202)
0.1 0.1 GO:0097354 protein prenylation(GO:0018342) prenylation(GO:0097354)
0.1 0.3 GO:0019359 NADP biosynthetic process(GO:0006741) nicotinamide nucleotide biosynthetic process(GO:0019359)
0.1 0.1 GO:0046497 nicotinate nucleotide biosynthetic process(GO:0019357) nicotinate nucleotide salvage(GO:0019358) pyridine nucleotide salvage(GO:0019365) nicotinate nucleotide metabolic process(GO:0046497)
0.1 0.2 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.1 0.2 GO:0043409 negative regulation of MAPK cascade(GO:0043409)
0.1 0.1 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.1 0.6 GO:0010528 regulation of transposition(GO:0010528)
0.1 0.1 GO:0032507 maintenance of protein location in cell(GO:0032507)
0.1 0.3 GO:0006469 negative regulation of protein kinase activity(GO:0006469) negative regulation of kinase activity(GO:0033673)
0.1 0.1 GO:0016078 tRNA catabolic process(GO:0016078) nuclear polyadenylation-dependent tRNA catabolic process(GO:0071038)
0.1 0.1 GO:0015809 arginine transport(GO:0015809)
0.1 0.2 GO:0016075 rRNA catabolic process(GO:0016075)
0.1 0.1 GO:0000101 sulfur amino acid transport(GO:0000101)
0.1 0.4 GO:0009303 rRNA transcription(GO:0009303)
0.1 0.1 GO:0045833 negative regulation of lipid metabolic process(GO:0045833)
0.1 0.6 GO:0006378 mRNA polyadenylation(GO:0006378)
0.1 0.1 GO:0045860 positive regulation of protein kinase activity(GO:0045860)
0.1 0.1 GO:0006379 mRNA cleavage(GO:0006379)
0.0 0.1 GO:0009411 response to UV(GO:0009411)
0.0 0.2 GO:0006814 sodium ion transport(GO:0006814)
0.0 0.1 GO:0006517 protein deglycosylation(GO:0006517)
0.0 0.2 GO:0000730 meiotic DNA recombinase assembly(GO:0000707) DNA recombinase assembly(GO:0000730)
0.0 0.1 GO:0006720 isoprenoid metabolic process(GO:0006720) isoprenoid biosynthetic process(GO:0008299)
0.0 0.0 GO:0032365 intracellular lipid transport(GO:0032365)
0.0 0.4 GO:0045859 regulation of protein kinase activity(GO:0045859)
0.0 0.0 GO:0006399 tRNA metabolic process(GO:0006399)
0.0 0.0 GO:0046939 nucleotide phosphorylation(GO:0046939)
0.0 0.0 GO:0009202 deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
0.0 0.1 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.1 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.1 GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)(GO:0000388)
0.0 0.2 GO:0006633 fatty acid biosynthetic process(GO:0006633)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.5 21.9 GO:0032160 septin filament array(GO:0032160)
5.0 15.1 GO:0030428 cell septum(GO:0030428)
5.0 59.9 GO:0000788 nuclear nucleosome(GO:0000788)
4.4 13.1 GO:0045298 polar microtubule(GO:0005827) tubulin complex(GO:0045298)
3.8 11.4 GO:0032299 ribonuclease H2 complex(GO:0032299)
3.5 14.1 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
3.2 16.0 GO:0000144 cellular bud neck septin ring(GO:0000144)
3.1 12.3 GO:0030907 MBF transcription complex(GO:0030907)
3.0 12.1 GO:0017053 transcriptional repressor complex(GO:0017053)
2.8 13.9 GO:0005871 kinesin complex(GO:0005871)
2.7 5.4 GO:0030131 clathrin adaptor complex(GO:0030131)
2.7 10.7 GO:0005880 nuclear microtubule(GO:0005880)
2.6 7.8 GO:0000262 cytoplasmic chromosome(GO:0000229) mitochondrial chromosome(GO:0000262)
2.5 210.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
2.4 146.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
2.3 13.6 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
2.1 2.1 GO:0032155 cell division site(GO:0032153) cell division site part(GO:0032155)
2.1 6.3 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
1.9 15.5 GO:0042597 periplasmic space(GO:0042597)
1.9 32.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
1.8 1.8 GO:0005884 actin filament(GO:0005884)
1.8 14.0 GO:0030126 COPI vesicle coat(GO:0030126)
1.7 12.0 GO:0000346 transcription export complex(GO:0000346)
1.6 6.6 GO:0031518 CBF3 complex(GO:0031518)
1.6 11.3 GO:0016459 myosin complex(GO:0016459)
1.6 6.3 GO:0034990 mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990)
1.5 4.6 GO:0070545 PeBoW complex(GO:0070545)
1.4 7.1 GO:0000408 EKC/KEOPS complex(GO:0000408)
1.4 8.2 GO:0043527 tRNA methyltransferase complex(GO:0043527)
1.3 9.2 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
1.3 1.3 GO:0000133 polarisome(GO:0000133)
1.3 12.7 GO:0042729 DASH complex(GO:0042729)
1.2 3.6 GO:0000814 ESCRT II complex(GO:0000814)
1.2 3.5 GO:0032301 MutSalpha complex(GO:0032301)
1.2 4.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
1.2 9.2 GO:0005688 U6 snRNP(GO:0005688)
1.2 4.6 GO:0044426 cell wall part(GO:0044426) external encapsulating structure part(GO:0044462)
1.1 8.0 GO:0044615 nuclear pore nuclear basket(GO:0044615)
1.1 5.7 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
1.1 3.4 GO:0030869 RENT complex(GO:0030869)
1.1 3.4 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
1.1 5.6 GO:0005663 DNA replication factor C complex(GO:0005663)
1.1 3.3 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
1.1 6.6 GO:0042555 MCM complex(GO:0042555)
1.1 3.3 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
1.1 3.2 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
1.1 15.9 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
1.0 7.3 GO:0016272 prefoldin complex(GO:0016272)
1.0 6.2 GO:0000136 alpha-1,6-mannosyltransferase complex(GO:0000136)
1.0 183.5 GO:0005933 cellular bud(GO:0005933)
1.0 7.8 GO:0005724 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
1.0 16.4 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.9 2.8 GO:0031417 NatC complex(GO:0031417)
0.9 3.6 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.9 15.3 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.9 3.6 GO:0055087 Ski complex(GO:0055087)
0.9 3.5 GO:0070860 RNA polymerase I core factor complex(GO:0070860)
0.9 2.6 GO:0008275 gamma-tubulin small complex, spindle pole body(GO:0000928) gamma-tubulin complex(GO:0000930) gamma-tubulin small complex(GO:0008275)
0.9 9.4 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.8 3.4 GO:0005797 Golgi medial cisterna(GO:0005797)
0.8 3.2 GO:0000938 GARP complex(GO:0000938)
0.8 1.6 GO:0016363 nuclear matrix(GO:0016363)
0.8 4.7 GO:0031499 TRAMP complex(GO:0031499)
0.7 3.0 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.7 5.2 GO:0031080 nuclear pore outer ring(GO:0031080)
0.7 3.7 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.7 2.2 GO:0097344 Rix1 complex(GO:0097344)
0.7 3.6 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.7 2.1 GO:0005662 DNA replication factor A complex(GO:0005662)
0.7 2.8 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.7 2.8 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.7 4.8 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.7 0.7 GO:0000145 exocyst(GO:0000145)
0.7 2.1 GO:0070939 Dsl1p complex(GO:0070939)
0.7 6.8 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.7 6.1 GO:0005655 nucleolar ribonuclease P complex(GO:0005655) multimeric ribonuclease P complex(GO:0030681)
0.7 4.6 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.7 2.0 GO:0034518 RNA cap binding complex(GO:0034518)
0.7 1.3 GO:0000786 nucleosome(GO:0000786)
0.6 2.5 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.6 3.1 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.6 1.8 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.6 7.7 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.6 10.6 GO:0016586 RSC complex(GO:0016586)
0.6 16.1 GO:0005844 polysome(GO:0005844)
0.6 4.6 GO:0017119 Golgi transport complex(GO:0017119)
0.6 2.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176) exosome (RNase complex)(GO:0000178)
0.6 22.6 GO:0030659 vesicle membrane(GO:0012506) cytoplasmic vesicle membrane(GO:0030659)
0.5 1.6 GO:0070209 ASTRA complex(GO:0070209)
0.5 3.7 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.5 0.5 GO:0005822 inner plaque of spindle pole body(GO:0005822)
0.5 1.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.5 19.4 GO:0005811 lipid particle(GO:0005811)
0.5 2.0 GO:0000811 GINS complex(GO:0000811)
0.5 3.5 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.5 3.4 GO:0005791 rough endoplasmic reticulum(GO:0005791) rough endoplasmic reticulum membrane(GO:0030867)
0.5 2.9 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.5 3.3 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.5 1.9 GO:0000818 MIS12/MIND type complex(GO:0000444) nuclear MIS12/MIND complex(GO:0000818)
0.5 1.4 GO:0071261 Ssh1 translocon complex(GO:0071261)
0.5 1.9 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.5 3.3 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.5 1.9 GO:0033179 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.5 1.4 GO:0044611 nuclear pore inner ring(GO:0044611)
0.5 2.3 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.4 0.4 GO:0030286 dynein complex(GO:0030286)
0.4 2.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.4 3.5 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.4 1.3 GO:0043529 GET complex(GO:0043529)
0.4 4.4 GO:0005876 spindle microtubule(GO:0005876)
0.4 4.7 GO:0005637 nuclear inner membrane(GO:0005637)
0.4 2.6 GO:0034456 UTP-C complex(GO:0034456)
0.4 0.8 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.4 1.6 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.4 0.4 GO:0031901 early endosome membrane(GO:0031901)
0.4 3.1 GO:0030008 TRAPP complex(GO:0030008)
0.4 0.8 GO:0031414 N-terminal protein acetyltransferase complex(GO:0031414)
0.4 4.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.4 2.3 GO:0070772 PAS complex(GO:0070772)
0.4 1.1 GO:0042575 DNA polymerase complex(GO:0042575)
0.4 2.2 GO:0034455 t-UTP complex(GO:0034455)
0.4 1.8 GO:0030689 Noc complex(GO:0030689)
0.4 1.5 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.4 1.1 GO:0005656 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.4 0.4 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.4 0.7 GO:0005796 Golgi lumen(GO:0005796)
0.4 8.2 GO:0030686 90S preribosome(GO:0030686)
0.4 14.8 GO:0000139 Golgi membrane(GO:0000139)
0.3 13.6 GO:0044445 cytosolic part(GO:0044445)
0.3 1.6 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.3 12.2 GO:0030427 site of polarized growth(GO:0030427)
0.3 1.6 GO:0034044 exomer complex(GO:0034044)
0.3 0.6 GO:0005823 central plaque of spindle pole body(GO:0005823)
0.3 5.5 GO:0030133 transport vesicle(GO:0030133)
0.3 2.5 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.3 1.2 GO:0000500 RNA polymerase I upstream activating factor complex(GO:0000500)
0.3 1.2 GO:0045254 mitochondrial pyruvate dehydrogenase complex(GO:0005967) pyruvate dehydrogenase complex(GO:0045254)
0.3 5.4 GO:0005685 U1 snRNP(GO:0005685)
0.3 0.9 GO:0033186 CAF-1 complex(GO:0033186)
0.3 6.1 GO:0032040 small-subunit processome(GO:0032040)
0.3 4.3 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.3 0.8 GO:0000137 Golgi cis cisterna(GO:0000137)
0.3 3.3 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.3 4.4 GO:0005802 trans-Golgi network(GO:0005802)
0.3 0.5 GO:0000798 nuclear cohesin complex(GO:0000798) cohesin complex(GO:0008278)
0.2 3.0 GO:0071010 U2-type prespliceosome(GO:0071004) prespliceosome(GO:0071010)
0.2 0.9 GO:0097196 Shu complex(GO:0097196)
0.2 1.2 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.2 0.7 GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network(GO:0042175)
0.2 6.4 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.2 0.9 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.2 13.1 GO:0005576 extracellular region(GO:0005576)
0.2 2.3 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.2 0.4 GO:0000792 heterochromatin(GO:0000792)
0.2 1.2 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.2 0.8 GO:0033597 mitotic checkpoint complex(GO:0033597)
0.2 0.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.2 20.2 GO:0005730 nucleolus(GO:0005730)
0.2 2.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.2 0.9 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.2 2.5 GO:0046695 SLIK (SAGA-like) complex(GO:0046695)
0.2 2.7 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.2 0.6 GO:0000817 COMA complex(GO:0000817)
0.2 0.8 GO:0030684 preribosome(GO:0030684)
0.1 33.8 GO:0005783 endoplasmic reticulum(GO:0005783)
0.1 0.3 GO:0000243 commitment complex(GO:0000243)
0.1 0.4 GO:0005825 half bridge of spindle pole body(GO:0005825)
0.1 0.4 GO:0070823 HDA1 complex(GO:0070823)
0.1 0.8 GO:0031011 Ino80 complex(GO:0031011)
0.1 0.4 GO:0044815 DNA packaging complex(GO:0044815)
0.1 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.3 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
0.1 0.2 GO:0016587 Isw1 complex(GO:0016587)
0.1 2.5 GO:0005794 Golgi apparatus(GO:0005794)
0.1 0.1 GO:0033202 DNA helicase complex(GO:0033202)
0.1 0.6 GO:0048188 histone methyltransferase complex(GO:0035097) Set1C/COMPASS complex(GO:0048188)
0.1 0.2 GO:0070985 TFIIK complex(GO:0070985)
0.1 0.1 GO:0071819 DUBm complex(GO:0071819)
0.1 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.1 GO:0005824 outer plaque of spindle pole body(GO:0005824)
0.0 0.1 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 0.9 GO:0070847 core mediator complex(GO:0070847)
0.0 0.0 GO:0005801 cis-Golgi network(GO:0005801)
0.0 1.1 GO:0005643 nuclear pore(GO:0005643)
0.0 0.2 GO:0031298 replication fork protection complex(GO:0031298)
0.0 0.2 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.4 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.1 GO:0030897 HOPS complex(GO:0030897)
0.0 0.2 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.0 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.0 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.9 17.7 GO:0009922 fatty acid elongase activity(GO:0009922)
5.8 17.5 GO:0070568 guanylyltransferase activity(GO:0070568)
4.2 12.5 GO:0051219 phosphoprotein binding(GO:0051219)
3.7 14.8 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
3.5 14.1 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
3.4 20.3 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
3.3 85.1 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
2.9 26.3 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
2.9 11.5 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
2.8 8.3 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
2.7 8.2 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
2.7 18.9 GO:0008422 beta-glucosidase activity(GO:0008422)
2.7 8.1 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
2.7 8.0 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
2.6 7.7 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
2.5 10.1 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)
2.4 14.4 GO:0003993 acid phosphatase activity(GO:0003993)
2.4 11.8 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
2.2 13.2 GO:0008312 7S RNA binding(GO:0008312)
2.0 12.2 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
2.0 10.0 GO:0000146 microfilament motor activity(GO:0000146)
2.0 9.9 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
2.0 9.9 GO:0008536 Ran GTPase binding(GO:0008536)
1.9 60.4 GO:0046982 protein heterodimerization activity(GO:0046982)
1.9 5.8 GO:0015440 peptide-transporting ATPase activity(GO:0015440)
1.8 7.4 GO:0016841 ammonia-lyase activity(GO:0016841)
1.8 18.3 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
1.8 7.2 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
1.8 12.4 GO:0019237 centromeric DNA binding(GO:0019237)
1.8 5.3 GO:0003938 IMP dehydrogenase activity(GO:0003938)
1.7 10.4 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
1.7 6.9 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
1.7 10.2 GO:0016408 C-acyltransferase activity(GO:0016408)
1.7 8.4 GO:0042123 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
1.7 3.3 GO:0008097 5S rRNA binding(GO:0008097)
1.7 6.7 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
1.6 4.9 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
1.6 325.7 GO:0003735 structural constituent of ribosome(GO:0003735)
1.5 7.4 GO:0004707 MAP kinase activity(GO:0004707)
1.4 2.9 GO:0070300 phosphatidic acid binding(GO:0070300)
1.4 9.8 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
1.4 5.5 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
1.4 11.0 GO:0003777 microtubule motor activity(GO:0003777)
1.3 20.0 GO:0015926 glucosidase activity(GO:0015926)
1.3 3.9 GO:0004100 chitin synthase activity(GO:0004100)
1.3 3.9 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
1.3 5.1 GO:0009378 four-way junction helicase activity(GO:0009378)
1.2 14.2 GO:0070491 repressing transcription factor binding(GO:0070491)
1.2 4.7 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
1.1 16.0 GO:0070566 adenylyltransferase activity(GO:0070566)
1.1 4.5 GO:0015198 oligopeptide transporter activity(GO:0015198)
1.1 6.6 GO:0005354 galactose transmembrane transporter activity(GO:0005354)
1.1 23.6 GO:0042162 telomeric DNA binding(GO:0042162)
1.1 4.3 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
1.0 4.1 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
1.0 8.0 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
1.0 1.0 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
1.0 9.9 GO:0005216 ion channel activity(GO:0005216)
1.0 5.7 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.9 4.7 GO:0005496 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.9 9.5 GO:0005516 calmodulin binding(GO:0005516)
0.9 5.6 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.9 2.8 GO:0051010 microtubule plus-end binding(GO:0051010)
0.9 2.7 GO:0003680 AT DNA binding(GO:0003680)
0.9 15.3 GO:0001056 RNA polymerase III activity(GO:0001056)
0.9 6.3 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.9 2.6 GO:0019003 GDP binding(GO:0019003)
0.8 8.2 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.8 3.2 GO:0004622 lysophospholipase activity(GO:0004622)
0.8 3.9 GO:0008443 phosphofructokinase activity(GO:0008443)
0.8 7.1 GO:0030276 clathrin binding(GO:0030276)
0.8 3.0 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.7 2.2 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.7 2.2 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.7 2.9 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.7 2.9 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.7 6.4 GO:0000009 alpha-1,6-mannosyltransferase activity(GO:0000009)
0.7 21.6 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.7 2.8 GO:0001055 RNA polymerase II activity(GO:0001055)
0.7 2.0 GO:0016504 peptidase activator activity(GO:0016504)
0.7 11.6 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.7 3.4 GO:0070546 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.7 10.8 GO:0042803 protein homodimerization activity(GO:0042803)
0.7 8.7 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)
0.7 3.3 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.7 2.0 GO:0000339 RNA cap binding(GO:0000339)
0.6 3.2 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.6 7.0 GO:0051015 actin filament binding(GO:0051015)
0.6 1.3 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.6 1.9 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.6 6.8 GO:0010181 FMN binding(GO:0010181)
0.6 4.9 GO:0003724 RNA helicase activity(GO:0003724)
0.6 1.2 GO:0016882 cyclo-ligase activity(GO:0016882)
0.6 2.4 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.6 3.0 GO:0008525 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.6 1.2 GO:1901681 sulfur compound binding(GO:1901681)
0.6 21.8 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.6 2.3 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.6 1.7 GO:0031370 eukaryotic initiation factor 4G binding(GO:0031370)
0.5 4.9 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.5 14.8 GO:0015631 tubulin binding(GO:0015631)
0.5 5.4 GO:0003727 single-stranded RNA binding(GO:0003727)
0.5 4.9 GO:0019904 protein domain specific binding(GO:0019904)
0.5 33.7 GO:0003924 GTPase activity(GO:0003924)
0.5 2.6 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.5 3.6 GO:0031490 chromatin DNA binding(GO:0031490)
0.5 1.0 GO:0019104 DNA N-glycosylase activity(GO:0019104)
0.5 2.0 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.5 2.5 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.5 1.5 GO:0016433 rRNA (adenine) methyltransferase activity(GO:0016433)
0.5 12.0 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.5 1.4 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.5 1.4 GO:0004017 adenylate kinase activity(GO:0004017)
0.5 1.9 GO:0004771 sterol esterase activity(GO:0004771)
0.5 2.4 GO:0003774 motor activity(GO:0003774)
0.5 3.3 GO:0001054 RNA polymerase I activity(GO:0001054)
0.5 4.2 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.5 1.4 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.5 2.8 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.5 5.5 GO:0005199 structural constituent of cell wall(GO:0005199)
0.5 1.8 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296) single-stranded DNA exodeoxyribonuclease activity(GO:0008297) single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.4 14.1 GO:0008092 cytoskeletal protein binding(GO:0008092)
0.4 2.6 GO:0016778 diphosphotransferase activity(GO:0016778)
0.4 3.5 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.4 1.7 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.4 6.9 GO:0008301 DNA binding, bending(GO:0008301)
0.4 1.7 GO:0043141 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.4 4.2 GO:0019843 rRNA binding(GO:0019843)
0.4 0.8 GO:0072341 modified amino acid binding(GO:0072341)
0.4 4.1 GO:0019239 deaminase activity(GO:0019239)
0.4 4.8 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.4 2.8 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.4 1.2 GO:0019901 protein kinase binding(GO:0019901)
0.4 4.3 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.4 1.9 GO:0030145 manganese ion binding(GO:0030145)
0.4 10.4 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.4 3.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.4 1.9 GO:0001139 transcription factor activity, core RNA polymerase II recruiting(GO:0001139)
0.4 1.5 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.4 2.6 GO:0019211 phosphatase activator activity(GO:0019211)
0.4 11.0 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.4 5.8 GO:0015616 DNA translocase activity(GO:0015616)
0.4 4.6 GO:0001671 ATPase activator activity(GO:0001671)
0.4 9.5 GO:0003743 translation initiation factor activity(GO:0003743)
0.3 0.7 GO:0016798 hydrolase activity, acting on glycosyl bonds(GO:0016798)
0.3 1.6 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.3 4.2 GO:0005048 signal sequence binding(GO:0005048)
0.3 1.6 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.3 7.0 GO:0016836 hydro-lyase activity(GO:0016836)
0.3 4.1 GO:0016279 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.3 1.2 GO:0001168 transcription factor activity, RNA polymerase I upstream control element sequence-specific binding(GO:0001168)
0.3 15.3 GO:0008565 protein transporter activity(GO:0008565)
0.3 0.9 GO:0004326 tetrahydrofolylpolyglutamate synthase activity(GO:0004326)
0.3 1.2 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.3 0.9 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825)
0.3 1.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.3 1.1 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.3 3.9 GO:0016866 intramolecular transferase activity(GO:0016866)
0.3 4.0 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.2 1.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.2 1.2 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.2 0.7 GO:0019202 amino acid kinase activity(GO:0019202)
0.2 0.7 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.2 1.7 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.2 0.7 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.2 0.7 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.2 0.9 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
0.2 9.6 GO:0005096 GTPase activator activity(GO:0005096)
0.2 1.8 GO:0000049 tRNA binding(GO:0000049)
0.2 0.5 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.2 1.5 GO:0030295 protein kinase activator activity(GO:0030295)
0.2 0.7 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.2 0.6 GO:0004691 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.2 0.4 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.2 6.4 GO:0000287 magnesium ion binding(GO:0000287)
0.2 1.6 GO:0016860 intramolecular oxidoreductase activity(GO:0016860)
0.2 0.4 GO:0019201 nucleotide kinase activity(GO:0019201)
0.2 0.8 GO:0042277 amide binding(GO:0033218) peptide binding(GO:0042277)
0.2 0.2 GO:0001181 transcription factor activity, core RNA polymerase I binding(GO:0001181)
0.2 1.1 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.2 1.2 GO:0017069 snRNA binding(GO:0017069)
0.2 1.9 GO:0003714 transcription corepressor activity(GO:0003714)
0.2 4.7 GO:0030674 protein binding, bridging(GO:0030674)
0.2 1.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887) DNA polymerase activity(GO:0034061)
0.2 0.2 GO:0003725 double-stranded RNA binding(GO:0003725)
0.2 0.8 GO:0004026 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.1 0.6 GO:0008242 omega peptidase activity(GO:0008242)
0.1 2.5 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 0.6 GO:0005034 osmosensor activity(GO:0005034)
0.1 0.9 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 0.6 GO:0000991 transcription factor activity, core RNA polymerase II binding(GO:0000991)
0.1 0.6 GO:0019206 nucleoside kinase activity(GO:0019206)
0.1 0.6 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 1.4 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.1 0.3 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.1 0.5 GO:0008135 translation factor activity, RNA binding(GO:0008135)
0.1 1.1 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.1 0.3 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 1.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 0.4 GO:0019207 kinase regulator activity(GO:0019207)
0.1 0.9 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 1.5 GO:0030515 snoRNA binding(GO:0030515)
0.1 0.1 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.1 3.1 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.1 0.1 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670) thiol oxidase activity(GO:0016972)
0.1 0.8 GO:0008170 N-methyltransferase activity(GO:0008170)
0.1 0.2 GO:0016835 carbon-oxygen lyase activity(GO:0016835)
0.1 1.4 GO:0050661 NADP binding(GO:0050661)
0.1 0.3 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.1 0.4 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.1 14.7 GO:0003723 RNA binding(GO:0003723)
0.1 0.5 GO:0000404 heteroduplex DNA loop binding(GO:0000404)
0.1 0.3 GO:0003951 NAD+ kinase activity(GO:0003951) NADH kinase activity(GO:0042736)
0.1 0.3 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 0.6 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.1 0.3 GO:0008169 C-methyltransferase activity(GO:0008169)
0.1 0.2 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.1 0.1 GO:0060090 binding, bridging(GO:0060090)
0.1 0.2 GO:0001128 RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly(GO:0001128)
0.1 0.2 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.1 0.3 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.1 GO:0008252 nucleotidase activity(GO:0008252)
0.0 0.0 GO:0001013 RNA polymerase I regulatory region DNA binding(GO:0001013)
0.0 0.2 GO:0008235 metalloexopeptidase activity(GO:0008235)
0.0 0.1 GO:0016410 N-acyltransferase activity(GO:0016410)
0.0 0.5 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.1 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.0 0.2 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 0.3 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0 0.1 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.5 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.7 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
1.5 6.0 PID E2F PATHWAY E2F transcription factor network
1.2 4.8 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
1.2 3.6 PID CDC42 PATHWAY CDC42 signaling events
1.1 4.2 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
1.0 9.2 PID ATR PATHWAY ATR signaling pathway
0.9 1.8 PID AURORA B PATHWAY Aurora B signaling
0.9 3.6 PID FGF PATHWAY FGF signaling pathway
0.8 1.6 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.7 2.1 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.7 3.4 PID PLK1 PATHWAY PLK1 signaling events
0.5 1.0 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.4 0.4 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.4 1.1 PID MYC PATHWAY C-MYC pathway
0.2 0.5 PID LKB1 PATHWAY LKB1 signaling events
0.1 0.2 ST FAS SIGNALING PATHWAY Fas Signaling Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 37.0 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
3.3 53.2 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
2.1 4.2 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
2.1 8.2 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
1.8 5.3 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
1.7 3.5 REACTOME G1 PHASE Genes involved in G1 Phase
1.5 7.6 REACTOME GPCR LIGAND BINDING Genes involved in GPCR ligand binding
1.3 5.3 REACTOME GLOBAL GENOMIC NER GG NER Genes involved in Global Genomic NER (GG-NER)
1.1 6.6 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
1.1 3.2 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
1.0 3.1 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
1.0 3.1 REACTOME SIGNALLING TO ERKS Genes involved in Signalling to ERKs
1.0 4.0 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.8 5.8 REACTOME DEADENYLATION DEPENDENT MRNA DECAY Genes involved in Deadenylation-dependent mRNA decay
0.8 2.3 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.7 3.6 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.7 0.7 REACTOME DEVELOPMENTAL BIOLOGY Genes involved in Developmental Biology
0.7 2.0 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.7 2.0 REACTOME HOST INTERACTIONS OF HIV FACTORS Genes involved in Host Interactions of HIV factors
0.6 5.6 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.6 1.8 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.6 3.5 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.6 1.1 REACTOME GPCR DOWNSTREAM SIGNALING Genes involved in GPCR downstream signaling
0.4 0.4 REACTOME INTERFERON SIGNALING Genes involved in Interferon Signaling
0.4 0.4 REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM Genes involved in Cytokine Signaling in Immune system
0.3 1.4 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.3 0.9 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.2 3.8 REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS Genes involved in Metabolism of lipids and lipoproteins
0.1 1.0 REACTOME PROTEIN FOLDING Genes involved in Protein folding
0.1 1.7 REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION Genes involved in Post-translational protein modification
0.1 1.2 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 0.4 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 0.1 REACTOME HIV INFECTION Genes involved in HIV Infection
0.1 0.1 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.0 0.0 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways