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Results for HAP5

Z-value: 1.89

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Transcription factors associated with HAP5

Gene Symbol Gene ID Gene Info
HAP5
S000005885 Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HAP5YOR358W0.601.1e-03Click!

Activity profile of HAP5 motif

Sorted Z-values of HAP5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YDR536W 17.20
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YKL148C 16.45
SDH1
Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YAL062W 14.36
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YML089C 13.94 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YEL008W 12.54 Hypothetical protein predicted to be involved in metabolism
YEL009C 11.60
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YDL204W 11.00
RTN2
Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily
YBL015W 9.88
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YOR343C 9.46 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YPR036W-A 9.20 Protein of unknown function; transcription is regulated by Pdr1p
YJR078W 8.94
BNA2
Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p
YML090W 8.56 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YOR378W 8.24 Putative protein of unknown function; belongs to the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
YDR231C 8.00
COX20
Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
YOL047C 7.95 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YER065C 7.65
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YAR053W 7.60 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL141W 7.53
SDH3
Cytochrome b subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YBR117C 7.50
TKL2
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YKL146W 7.47
AVT3
Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YKL147C 7.33 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3
YGL062W 7.10
PYC1
Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis
YBL030C 7.10
PET9
Major ADP/ATP carrier of the mitochondrial inner membrane, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; required for viability in many common lab strains carrying a mutation in the polymorphic SAL1 gene
YLR122C 6.80 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YDL181W 6.76
INH1
Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has similarity to Stf1p; has a calmodulin-binding motif and binds calmodulin in vitro
YER158C 6.70 Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p
YMR256C 6.59
COX7
Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YMR107W 6.50
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YDR232W 6.36
HEM1
5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
YCR005C 6.24
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YBR230C 6.10
OM14
Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron
YDL067C 6.09
COX9
Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YGL191W 6.06
COX13
Subunit VIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP
YML091C 6.06
RPM2
Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
YFR053C 5.95
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YKL085W 5.84
MDH1
Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated
YAR060C 5.81 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL187C 5.71
COX4
Subunit IV of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; N-terminal 25 residues of precursor are cleaved during mitochondrial import; phosphorylated
YLR123C 5.54 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YLR004C 5.47
THI73
Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
YER033C 5.38
ZRG8
Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency
YJR077C 5.23
MIR1
Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated
YBR039W 5.13
ATP3
Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YJL166W 5.07
QCR8
Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
YNL052W 5.05
COX5A
Subunit Va of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth
YPL201C 4.93
YIG1
Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol
YNR002C 4.75
ATO2
Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p
YBL099W 4.73
ATP1
Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YJL116C 4.72
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YLL041C 4.69
SDH2
Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YBL100C 4.68 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the 5' end of ATP1
YDR529C 4.62
QCR7
Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly
YJL103C 4.61
GSM1
Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis
YCL001W-B 4.52 Putative protein of unknown function; identified by homology
YPL078C 4.51
ATP4
Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YCL057C-A 4.50 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YHL040C 4.49
ARN1
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores
YIL055C 4.43 Putative protein of unknown function
YDR342C 4.38
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YBR105C 4.22
VID24
Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; involved in proteasome-dependent catabolite degradation of FBPase
YOL084W 4.18
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YGL248W 4.16
PDE1
Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation
YGR183C 4.14
QCR9
Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
YKL016C 4.14
ATP7
Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YPR015C 4.04 Putative protein of unknown function
YDR322C-A 3.96
TIM11
Subunit e of mitochondrial F1F0-ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthase
YIL059C 3.95 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W
YHR199C 3.92
AIM46
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YDR277C 3.87
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YPL262W 3.77
FUM1
Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation; phosphorylated in mitochondria
YDR377W 3.74
ATP17
Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YLR023C 3.72
IZH3
Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
YHR145C 3.70 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YAL063C 3.67
FLO9
Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
YEL065W 3.66
SIT1
Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
YHR211W 3.66
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YLR125W 3.58 Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene
YML081C-A 3.55
ATP18
Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms
YPL200W 3.54
CSM4
Protein required for accurate chromosome segregation during meiosis
YOL077W-A 3.51
ATP19
Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase
YPR010C-A 3.50 Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YOR186C-A 3.47 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YLR124W 3.45 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YEL007W 3.45 Putative protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1)
YNL074C 3.44
MLF3
Serine-rich protein of unknown function; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
YIL162W 3.44
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YMR118C 3.42 Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene
YMR271C 3.39
URA10
Minor orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; major OPRTase encoded by URA5
YDL170W 3.36
UGA3
Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus
YPL111W 3.31
CAR1
Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance
YGR121C 3.30
MEP1
Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YPL135W 3.29
ISU1
Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable
YHR212C 3.26 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR192C 3.24
THI72
Transporter of thiamine or related compound; shares sequence similarity with Thi7p
YDR476C 3.22 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene
YGL219C 3.22
MDM34
Mitochondrial outer membrane protein, required for normal mitochondrial morphology and inheritance; localizes to dots on the mitochondrial surface near mtDNA nucleoids; interacts genetically with MDM31 and MDM32
YJL102W 3.18
MEF2
Mitochondrial elongation factor involved in translational elongation
YOR382W 3.12
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YLR236C 3.11 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL333W 3.09
SNZ2
Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p
YHR139C 3.04
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YDR247W 3.03
VHS1
Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p
YLR174W 3.02
IDP2
Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
YFR033C 2.95
QCR6
Subunit 6 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1
YLL056C 2.94 Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene
YML120C 2.92
NDI1
NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID
YLR237W 2.90
THI7
Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
YFL019C 2.89 Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene
YLL055W 2.89
YCT1
High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
YLR235C 2.85 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TOP3
YPL183W-A 2.84
RTC6
Homolog of the prokaryotic ribosomal protein L36, likely to be a mitochondrial ribosomal protein coded in the nuclear genome; null mutation suppresses cdc13-1 temperature sensitivity
YPR151C 2.82
SUE1
Mitochondrial protein required for degradation of unstable forms of cytochrome c
YAL039C 2.80
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YNL242W 2.79
ATG2
Peripheral membrane protein required for vesicle formation during autophagy, pexophagy, and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the pre-autophagosomal structure and mitochondria
YBR147W 2.77
RTC2
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays fluconazole resistance and suppresses cdc13-1 temperature sensitivity
YBR218C 2.74
PYC2
Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosis
YOR192C-C 2.74 Putative protein of unknown function; identified by expression profiling and mass spectrometry
YPL230W 2.70
USV1
Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in protein folding, ATP binding, and cell wall biosynthesis
YOR072W 2.68 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YHR212W-A 2.68 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YHR008C 2.68
SOD2
Mitochondrial superoxide dismutase, protects cells against oxygen toxicity; phosphorylated
YNL101W 2.66
AVT4
Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YER053C 2.66
PIC2
Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature
YGR149W 2.65 Putative protein of unknown function; predicted to be an integal membrane protein
YBL045C 2.62
COR1
Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain
YNR034W-A 2.58 Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YER101C 2.55
AST2
Protein that may have a role in targeting of plasma membrane [H+]ATPase (Pma1p) to the plasma membrane, as suggested by analysis of genetic interactions
YDR173C 2.54
ARG82
Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes
YJR154W 2.52 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YBR230W-A 2.50 Putative protein of unknown function
YJL043W 2.42 Putative protein of unknown function; YJL043W is a non-essential gene
YOL081W 2.41
IRA2
GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin
YOR376W 2.40 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.
YNL088W 2.40
TOP2
Essential type II topoisomerase, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis
YGR236C 2.39
SPG1
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YHR092C 2.39
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YAR023C 2.37 Putative integral membrane protein, member of DUP240 gene family
YOR071C 2.36
NRT1
High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
YER066W 2.32 Putative protein of unknown function; YER066W is not an essential gene
YOR072W-A 2.28 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR072W; originally identified by fungal homology and RT-PCR
YOR100C 2.28
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YNL334C 2.27
SNO2
Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin
YDR405W 2.24
MRP20
Mitochondrial ribosomal protein of the large subunit
YKL151C 2.22 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YPL240C 2.21
HSP82
Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
YDR298C 2.17
ATP5
Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
YBR209W 2.16 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR209W is not an essential gene
YPL181W 2.16
CTI6
Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain
YJL100W 2.14
LSB6
Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
YNL190W 2.11 Cell wall protein of unknown function; proposed role as a hydrophilin induced by osmotic stress; contains a putative GPI-attachment site
YKL163W 1.99
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YFL044C 1.98
OTU1
Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family
YPL182C 1.98 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W
YDL214C 1.97
PRR2
Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
YHR048W 1.96
YHK8
Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
YFR007W 1.93
YFH7
Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YKR102W 1.92
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YER175C 1.92
TMT1
Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle
YOR228C 1.92 Protein of unknown function, localized to the mitochondrial outer membrane
YMR145C 1.90
NDE1
Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain
YLR228C 1.88
ECM22
Sterol regulatory element binding protein, regulates transcription of the sterol biosynthetic genes ERG2 and ERG3; member of the fungus-specific Zn[2]-Cys[6] binuclear cluster family of transcription factors; homologous to Upc2p
YHR051W 1.88
COX6
Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels
YLR395C 1.87
COX8
Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YDR148C 1.87
KGD2
Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
YFL020C 1.85
PAU5
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YHL046W-A 1.84 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL154W 1.83
ZPS1
Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
YOL085W-A 1.82 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YOL085C
YLR307C-A 1.82 Putative protein of unknown function
YMR306W 1.81
FKS3
Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YMR148W 1.78 Putative protein of unknown function; predicted to contain a transmembrane domain; YMR148W is not an essential gene
YFR017C 1.77 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene
YKL067W 1.76
YNK1
Nucleoside diphosphate kinase, catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate
YDR223W 1.74
CRF1
Transcriptional corepressor involved in the regulation of ribosomal protein gene transcription via the TOR signaling pathway and protein kinase A, phosphorylated by activated Yak1p which promotes accumulation of Crf1p in the nucleus
YHL047C 1.72
ARN2
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C
YBL066C 1.72
SEF1
Putative transcription factor, has homolog in Kluyveromyces lactis
YKR062W 1.71
TFA2
TFIIE small subunit, involved in RNA polymerase II transcription initiation
YKL107W 1.69 Putative protein of unknown function
YPR084W 1.66 Putative protein of unknown function
YPL187W 1.65
MF(ALPHA)1
Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor
YPL224C 1.65
MMT2
Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p
YLR375W 1.65
STP3
Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids
YMR103C 1.64 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL045W 1.63 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YKL197C 1.61
PEX1
AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis
YDR453C 1.59
TSA2
Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants
YOL053W 1.59
AIM39
Putative protein of unknown function; YOL053W is not an essential gene; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YJR151C 1.58
DAN4
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YLR374C 1.57 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W
YBL065W 1.56 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene
YPL278C 1.56 Putative protein of unknown function; gene expression regulated by copper levels
YLR378C 1.56
SEC61
Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER
YCL040W 1.54
GLK1
Glucokinase, catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources
YMR018W 1.54 Putative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein); transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene
YFR045W 1.51 Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white
YLR327C 1.50
TMA10
Protein of unknown function that associates with ribosomes
YPR193C 1.49
HPA2
Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity
YML087C 1.49
AIM33
Putative protein of unknown function; highly conserved across species and orthologous to human CYB5R4; null mutant shows increased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YNL240C 1.47
NAR1
Nuclear architecture related protein; component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins; homologous to human Narf
YHR210C 1.47 Putative protein of unknown function; non-essential gene; highly expressed under anaeorbic conditions; sequence similarity to aldose 1-epimerases such as GAL10

Network of associatons between targets according to the STRING database.

First level regulatory network of HAP5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.7 28.7 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
3.3 13.3 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
3.1 15.7 GO:0015793 glycerol transport(GO:0015793)
3.0 27.2 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
2.9 8.7 GO:0019676 ammonia assimilation cycle(GO:0019676)
2.8 8.5 GO:0015888 thiamine transport(GO:0015888)
2.8 8.5 GO:0035786 protein complex oligomerization(GO:0035786)
2.6 28.5 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
2.6 12.9 GO:0034486 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
2.3 9.2 GO:0045980 negative regulation of nucleotide metabolic process(GO:0045980)
2.2 24.3 GO:0006119 oxidative phosphorylation(GO:0006119)
2.2 11.0 GO:0043954 cellular component maintenance(GO:0043954)
2.2 8.6 GO:0046323 glucose import(GO:0046323)
2.0 18.1 GO:0006097 glyoxylate cycle(GO:0006097)
2.0 9.9 GO:0034627 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
1.9 5.8 GO:0006108 malate metabolic process(GO:0006108)
1.9 7.5 GO:0015886 heme transport(GO:0015886)
1.6 11.4 GO:0006083 acetate metabolic process(GO:0006083)
1.4 8.6 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
1.4 4.2 GO:0051469 vesicle fusion with vacuole(GO:0051469)
1.4 4.2 GO:0046058 cAMP metabolic process(GO:0046058)
1.3 10.2 GO:0015891 siderophore transport(GO:0015891)
1.2 3.7 GO:0072488 ammonium transmembrane transport(GO:0072488)
1.2 3.6 GO:0019627 urea metabolic process(GO:0019627)
1.1 4.3 GO:0009448 gamma-aminobutyric acid metabolic process(GO:0009448) gamma-aminobutyric acid catabolic process(GO:0009450)
1.0 3.9 GO:0045141 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.9 2.8 GO:0017003 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.9 2.7 GO:0072353 cellular age-dependent response to reactive oxygen species(GO:0072353)
0.9 6.9 GO:0042816 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.9 2.6 GO:0000101 sulfur amino acid transport(GO:0000101)
0.8 2.4 GO:0031055 chromatin remodeling at centromere(GO:0031055)
0.8 3.0 GO:2000911 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.7 1.5 GO:0006102 isocitrate metabolic process(GO:0006102)
0.7 2.9 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.7 9.5 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.7 2.1 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.7 0.7 GO:0006538 glutamate catabolic process(GO:0006538)
0.6 4.5 GO:0015758 glucose transport(GO:0015758)
0.6 2.5 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.6 2.4 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.6 1.8 GO:0046039 GTP biosynthetic process(GO:0006183) GTP metabolic process(GO:0046039)
0.6 3.4 GO:0044205 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.5 2.0 GO:0031138 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.5 3.5 GO:0006101 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101)
0.5 3.9 GO:0005985 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.5 0.9 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.5 1.8 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
0.4 1.8 GO:0009229 thiamine diphosphate biosynthetic process(GO:0009229) thiamine diphosphate metabolic process(GO:0042357)
0.4 0.4 GO:0006740 NADPH regeneration(GO:0006740)
0.4 0.4 GO:0034225 cellular response to zinc ion starvation(GO:0034224) regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation(GO:0034225)
0.4 1.2 GO:0070199 establishment of protein localization to chromosome(GO:0070199) establishment of protein localization to chromatin(GO:0071169)
0.4 1.6 GO:0015976 carbon utilization(GO:0015976)
0.4 10.3 GO:0006094 gluconeogenesis(GO:0006094)
0.4 1.6 GO:1903513 retrograde protein transport, ER to cytosol(GO:0030970) endoplasmic reticulum to cytosol transport(GO:1903513)
0.4 5.0 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.4 1.1 GO:0005993 trehalose catabolic process(GO:0005993)
0.4 2.2 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.4 0.4 GO:0043902 positive regulation of multi-organism process(GO:0043902)
0.4 4.7 GO:0015749 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.4 1.1 GO:0015847 putrescine transport(GO:0015847)
0.3 4.4 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.3 1.6 GO:0043112 receptor recycling(GO:0001881) protein import into peroxisome matrix, receptor recycling(GO:0016562) receptor metabolic process(GO:0043112)
0.3 0.9 GO:0042743 hydrogen peroxide metabolic process(GO:0042743) hydrogen peroxide catabolic process(GO:0042744)
0.3 0.9 GO:0042407 cristae formation(GO:0042407)
0.3 0.9 GO:0042843 D-xylose catabolic process(GO:0042843)
0.3 9.9 GO:0009060 aerobic respiration(GO:0009060)
0.3 3.3 GO:0015893 drug transport(GO:0015893)
0.3 0.9 GO:0001111 promoter clearance during DNA-templated transcription(GO:0001109) promoter clearance from RNA polymerase II promoter(GO:0001111)
0.3 1.2 GO:0046688 response to copper ion(GO:0046688)
0.3 1.2 GO:0043388 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
0.3 1.4 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.3 0.6 GO:0006343 establishment of chromatin silencing(GO:0006343)
0.3 2.2 GO:0061188 negative regulation of chromatin silencing at rDNA(GO:0061188)
0.3 1.1 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.3 0.3 GO:0097035 lipid translocation(GO:0034204) regulation of membrane lipid distribution(GO:0097035)
0.3 2.3 GO:0006882 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.3 0.5 GO:0051228 mitotic spindle disassembly(GO:0051228) spindle disassembly(GO:0051230)
0.2 1.5 GO:0051260 protein homooligomerization(GO:0051260)
0.2 1.1 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
0.2 0.9 GO:0019184 glutathione biosynthetic process(GO:0006750) nonribosomal peptide biosynthetic process(GO:0019184)
0.2 0.9 GO:0019405 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.2 2.1 GO:0015802 basic amino acid transport(GO:0015802)
0.2 4.8 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.2 2.9 GO:0019740 nitrogen utilization(GO:0019740)
0.2 1.2 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.2 1.6 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.2 0.8 GO:0032056 positive regulation of translation in response to stress(GO:0032056)
0.2 0.4 GO:0042148 strand invasion(GO:0042148)
0.2 0.2 GO:1900182 positive regulation of protein localization to nucleus(GO:1900182) positive regulation of cellular protein localization(GO:1903829)
0.2 0.7 GO:0051654 establishment of mitochondrion localization(GO:0051654)
0.2 0.9 GO:0070124 mitochondrial translational initiation(GO:0070124)
0.2 0.5 GO:0006000 fructose metabolic process(GO:0006000) fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.2 0.7 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.2 3.5 GO:0015914 phospholipid transport(GO:0015914)
0.2 2.2 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.2 2.4 GO:0042493 response to drug(GO:0042493)
0.2 3.4 GO:0016579 protein deubiquitination(GO:0016579)
0.2 2.0 GO:0046854 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.2 0.2 GO:0061187 regulation of chromatin silencing at rDNA(GO:0061187)
0.1 4.3 GO:0098660 inorganic ion transmembrane transport(GO:0098660)
0.1 0.4 GO:0030491 heteroduplex formation(GO:0030491)
0.1 1.4 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.1 1.9 GO:0000147 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.1 0.1 GO:0000709 meiotic joint molecule formation(GO:0000709)
0.1 0.9 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.1 1.2 GO:0009651 response to salt stress(GO:0009651)
0.1 0.8 GO:0046686 response to cadmium ion(GO:0046686)
0.1 0.3 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.1 0.3 GO:0072530 cytosine transport(GO:0015856) purine-containing compound transmembrane transport(GO:0072530)
0.1 0.6 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.1 0.3 GO:0042173 regulation of sporulation resulting in formation of a cellular spore(GO:0042173)
0.1 0.2 GO:0042710 biofilm formation(GO:0042710)
0.1 1.4 GO:0000753 cell morphogenesis involved in conjugation with cellular fusion(GO:0000753)
0.1 0.9 GO:0072348 sulfur compound transport(GO:0072348)
0.1 1.2 GO:0030952 establishment or maintenance of actin cytoskeleton polarity(GO:0030950) establishment or maintenance of cytoskeleton polarity(GO:0030952)
0.1 0.3 GO:0071825 lipid tube assembly(GO:0060988) protein-lipid complex assembly(GO:0065005) protein-lipid complex subunit organization(GO:0071825)
0.1 0.3 GO:0072479 cellular response to biotic stimulus(GO:0071216) response to cell cycle checkpoint signaling(GO:0072396) response to mitotic cell cycle checkpoint signaling(GO:0072414) response to spindle checkpoint signaling(GO:0072417) response to mitotic spindle checkpoint signaling(GO:0072476) response to mitotic cell cycle spindle assembly checkpoint signaling(GO:0072479) response to spindle assembly checkpoint signaling(GO:0072485) negative regulation of protein import into nucleus during spindle assembly checkpoint(GO:1901925)
0.1 2.5 GO:0006312 mitotic recombination(GO:0006312)
0.1 0.8 GO:0051181 cofactor transport(GO:0051181)
0.1 1.3 GO:0006885 regulation of pH(GO:0006885)
0.1 0.3 GO:0046466 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.1 0.8 GO:0031167 rRNA methylation(GO:0031167)
0.1 0.3 GO:0019748 secondary metabolic process(GO:0019748)
0.1 0.2 GO:0009415 response to water(GO:0009415) cellular response to water stimulus(GO:0071462)
0.1 1.7 GO:0006378 mRNA polyadenylation(GO:0006378)
0.1 0.3 GO:0018206 N-terminal peptidyl-methionine acetylation(GO:0017196) peptidyl-methionine modification(GO:0018206)
0.1 0.2 GO:0044209 AMP salvage(GO:0044209)
0.1 0.7 GO:0070987 error-free translesion synthesis(GO:0070987)
0.1 0.6 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.1 0.7 GO:0071709 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.1 0.2 GO:0032874 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.1 0.9 GO:0000272 polysaccharide catabolic process(GO:0000272)
0.1 0.9 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.1 0.6 GO:0006878 cellular copper ion homeostasis(GO:0006878) copper ion homeostasis(GO:0055070)
0.1 0.6 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.1 0.6 GO:0006078 (1->6)-beta-D-glucan biosynthetic process(GO:0006078)
0.1 0.3 GO:0009395 phospholipid catabolic process(GO:0009395)
0.1 0.1 GO:0070932 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.1 0.4 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.1 0.1 GO:0042732 D-xylose metabolic process(GO:0042732)
0.1 1.2 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 0.3 GO:0031333 negative regulation of protein complex assembly(GO:0031333)
0.1 5.7 GO:0032543 mitochondrial translation(GO:0032543)
0.1 0.3 GO:0000023 maltose metabolic process(GO:0000023)
0.1 5.5 GO:0007005 mitochondrion organization(GO:0007005)
0.1 1.4 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.9 GO:0048278 vesicle docking(GO:0048278)
0.0 0.9 GO:0001300 chronological cell aging(GO:0001300)
0.0 0.4 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.3 GO:0030042 actin filament depolymerization(GO:0030042)
0.0 0.1 GO:0034059 response to anoxia(GO:0034059) cellular response to anoxia(GO:0071454)
0.0 0.2 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.0 0.3 GO:0010526 negative regulation of transposition, RNA-mediated(GO:0010526) negative regulation of transposition(GO:0010529)
0.0 0.2 GO:0007532 regulation of mating-type specific transcription, DNA-templated(GO:0007532)
0.0 0.5 GO:0007266 Rho protein signal transduction(GO:0007266)
0.0 1.6 GO:0044843 G1/S transition of mitotic cell cycle(GO:0000082) cell cycle G1/S phase transition(GO:0044843)
0.0 0.2 GO:0006661 phosphatidylinositol biosynthetic process(GO:0006661)
0.0 0.5 GO:0009267 cellular response to starvation(GO:0009267)
0.0 0.1 GO:0006687 glycosphingolipid metabolic process(GO:0006687)
0.0 0.1 GO:0019933 cAMP-mediated signaling(GO:0019933) cyclic-nucleotide-mediated signaling(GO:0019935)
0.0 0.0 GO:1900544 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.0 0.1 GO:0006531 aspartate metabolic process(GO:0006531)
0.0 0.3 GO:0000742 karyogamy involved in conjugation with cellular fusion(GO:0000742)
0.0 0.1 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.1 GO:0043605 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256) cellular amide catabolic process(GO:0043605)
0.0 0.1 GO:0006048 UDP-N-acetylglucosamine metabolic process(GO:0006047) UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.5 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.0 0.3 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 0.1 GO:0009756 cellular glucose homeostasis(GO:0001678) carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255) carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.0 0.2 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.2 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.1 GO:0010528 regulation of transposition(GO:0010528)
0.0 1.4 GO:0031505 fungal-type cell wall organization(GO:0031505)
0.0 0.1 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.1 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.0 GO:0006086 acetyl-CoA biosynthetic process(GO:0006085) acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.0 0.1 GO:0007039 protein catabolic process in the vacuole(GO:0007039)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.7 28.7 GO:0045257 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
3.9 34.7 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
3.6 10.8 GO:0045265 mitochondrial proton-transporting ATP synthase, stator stalk(GO:0000274) proton-transporting ATP synthase, stator stalk(GO:0045265)
2.5 14.8 GO:0045263 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
2.3 11.4 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
2.2 19.4 GO:0098803 mitochondrial respiratory chain(GO:0005746) respiratory chain complex(GO:0098803)
1.4 8.2 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
1.0 2.9 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.6 3.2 GO:0044233 ERMES complex(GO:0032865) ER-mitochondrion membrane contact site(GO:0044233)
0.6 2.5 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.6 4.2 GO:0034657 GID complex(GO:0034657)
0.6 2.4 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.5 8.7 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.5 5.1 GO:0030677 ribonuclease P complex(GO:0030677)
0.5 1.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.4 5.2 GO:0005619 ascospore wall(GO:0005619)
0.4 7.0 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.4 6.4 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.3 3.0 GO:0000795 synaptonemal complex(GO:0000795)
0.3 2.3 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.3 2.0 GO:0009277 fungal-type cell wall(GO:0009277)
0.3 0.9 GO:0005784 Sec61 translocon complex(GO:0005784)
0.3 1.2 GO:0032116 SMC loading complex(GO:0032116)
0.3 0.9 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.3 0.9 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.3 0.9 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.3 1.1 GO:0030287 cell wall-bounded periplasmic space(GO:0030287)
0.3 0.5 GO:0032126 eisosome(GO:0032126)
0.2 1.4 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.2 0.7 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.2 10.3 GO:0031225 anchored component of membrane(GO:0031225)
0.2 10.8 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.2 1.2 GO:0031932 TORC2 complex(GO:0031932)
0.2 0.6 GO:0032585 multivesicular body membrane(GO:0032585)
0.2 20.7 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.2 2.2 GO:0098552 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.2 0.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 2.2 GO:0033698 Rpd3L complex(GO:0033698)
0.1 2.5 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 0.5 GO:0005825 half bridge of spindle pole body(GO:0005825)
0.1 0.8 GO:0005677 chromatin silencing complex(GO:0005677)
0.1 0.3 GO:0000813 ESCRT I complex(GO:0000813)
0.1 0.2 GO:0016363 nuclear matrix(GO:0016363)
0.1 4.3 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 3.5 GO:0005576 extracellular region(GO:0005576)
0.1 1.0 GO:0005769 early endosome(GO:0005769)
0.1 0.4 GO:0016587 Isw1 complex(GO:0016587)
0.1 0.5 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.1 53.4 GO:0005739 mitochondrion(GO:0005739)
0.1 0.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 1.1 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.1 22.9 GO:0005886 plasma membrane(GO:0005886)
0.1 0.4 GO:0005775 fungal-type vacuole lumen(GO:0000328) vacuolar lumen(GO:0005775)
0.1 1.4 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 6.6 GO:0098852 fungal-type vacuole membrane(GO:0000329) lytic vacuole membrane(GO:0098852)
0.1 2.5 GO:0030479 actin cortical patch(GO:0030479) endocytic patch(GO:0061645)
0.1 0.2 GO:0070210 Rpd3L-Expanded complex(GO:0070210)
0.1 0.6 GO:0034399 nuclear periphery(GO:0034399)
0.1 0.1 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.8 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 0.1 GO:0005871 kinesin complex(GO:0005871)
0.0 0.4 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.4 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.4 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.4 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.0 0.1 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.1 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.5 GO:0043332 mating projection tip(GO:0043332)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.7 28.7 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
3.7 18.3 GO:0015295 solute:proton symporter activity(GO:0015295)
3.5 34.7 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
3.4 10.1 GO:0005302 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
3.3 9.9 GO:0016289 CoA hydrolase activity(GO:0016289)
2.6 28.5 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
2.6 7.7 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
2.5 10.1 GO:0005537 mannose binding(GO:0005537)
2.5 9.9 GO:0015603 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
2.4 9.8 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
2.4 19.4 GO:0016679 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
2.2 8.7 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
2.1 6.2 GO:0003954 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
1.9 5.8 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
1.9 7.6 GO:0004396 hexokinase activity(GO:0004396)
1.7 6.8 GO:0005347 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
1.7 6.8 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
1.4 4.2 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
1.4 6.9 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
1.3 3.9 GO:0016872 intramolecular lyase activity(GO:0016872)
1.1 3.4 GO:0004564 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
1.1 3.3 GO:1901474 azole transmembrane transporter activity(GO:1901474)
1.1 7.6 GO:0016833 oxo-acid-lyase activity(GO:0016833)
1.1 6.5 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
1.0 8.4 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
1.0 4.2 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.9 2.8 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.9 10.8 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.8 2.5 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.7 1.5 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.7 6.0 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.7 3.3 GO:0008198 ferrous iron binding(GO:0008198)
0.6 8.2 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.6 4.2 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.6 3.6 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.6 1.8 GO:0008972 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.6 2.2 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.6 2.2 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.5 2.6 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.5 2.6 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.5 5.1 GO:0004526 ribonuclease P activity(GO:0004526)
0.5 1.9 GO:0016417 S-acyltransferase activity(GO:0016417)
0.5 1.4 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.5 1.8 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
0.4 1.7 GO:0000772 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.4 1.1 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.4 1.1 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.4 1.1 GO:0004738 pyruvate dehydrogenase activity(GO:0004738)
0.3 0.3 GO:0004075 biotin carboxylase activity(GO:0004075)
0.3 0.9 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.3 1.5 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.3 1.4 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.3 0.8 GO:0004629 phospholipase C activity(GO:0004629)
0.3 1.6 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.3 1.3 GO:0070403 NAD+ binding(GO:0070403)
0.3 7.0 GO:0004857 enzyme inhibitor activity(GO:0004857)
0.2 2.0 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.2 0.9 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.2 1.6 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.2 2.2 GO:0035064 methylated histone binding(GO:0035064)
0.2 2.1 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.2 1.4 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.2 0.8 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.2 0.6 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139)
0.2 0.8 GO:0004180 carboxypeptidase activity(GO:0004180)
0.2 3.6 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.2 1.1 GO:0000400 four-way junction DNA binding(GO:0000400)
0.2 1.2 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.2 0.9 GO:0008171 O-methyltransferase activity(GO:0008171)
0.2 0.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2 1.2 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.2 1.3 GO:0000149 SNARE binding(GO:0000149)
0.2 0.7 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.2 1.6 GO:0015238 drug transmembrane transporter activity(GO:0015238)
0.2 0.5 GO:0055106 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106) ubiquitin-protein transferase activator activity(GO:0097027)
0.2 0.8 GO:0005354 galactose transmembrane transporter activity(GO:0005354)
0.2 2.4 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.1 1.8 GO:0005199 structural constituent of cell wall(GO:0005199)
0.1 0.9 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
0.1 1.1 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.1 6.4 GO:0016410 N-acyltransferase activity(GO:0016410)
0.1 2.5 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.1 0.4 GO:0000150 recombinase activity(GO:0000150)
0.1 0.3 GO:0042947 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.1 0.1 GO:0000104 succinate dehydrogenase activity(GO:0000104)
0.1 2.1 GO:0015297 antiporter activity(GO:0015297)
0.1 0.6 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.1 1.2 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 0.5 GO:0019776 Atg8 ligase activity(GO:0019776)
0.1 0.5 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.1 1.6 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 0.6 GO:0017022 myosin binding(GO:0017022)
0.1 0.3 GO:0008897 holo-[acyl-carrier-protein] synthase activity(GO:0008897)
0.1 0.3 GO:0001129 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129)
0.1 1.3 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 0.5 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.1 1.3 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 0.9 GO:0016684 peroxidase activity(GO:0004601) oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)
0.1 0.4 GO:0004338 glucan exo-1,3-beta-glucosidase activity(GO:0004338)
0.1 0.8 GO:0010181 FMN binding(GO:0010181)
0.1 0.2 GO:0008106 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.1 0.3 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 0.8 GO:0051184 cofactor transporter activity(GO:0051184)
0.1 5.7 GO:0051082 unfolded protein binding(GO:0051082)
0.1 0.8 GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism(GO:0015662)
0.1 1.4 GO:0016836 hydro-lyase activity(GO:0016836)
0.1 0.5 GO:0098847 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.1 1.4 GO:0015399 primary active transmembrane transporter activity(GO:0015399) P-P-bond-hydrolysis-driven transmembrane transporter activity(GO:0015405)
0.1 0.2 GO:0004026 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.1 0.4 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 0.7 GO:0038023 transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) transmembrane receptor activity(GO:0099600)
0.1 0.7 GO:0005507 copper ion binding(GO:0005507)
0.1 0.1 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.1 1.5 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.1 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.0 0.8 GO:0008374 O-acyltransferase activity(GO:0008374)
0.0 0.1 GO:0032183 SUMO binding(GO:0032183)
0.0 0.5 GO:0045182 translation regulator activity(GO:0045182)
0.0 0.1 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025) TFIIIC-class transcription factor binding(GO:0001156)
0.0 0.1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.4 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.1 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.0 0.1 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 0.4 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.0 0.1 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H3-K9 specific)(GO:0032129) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970) NAD-dependent histone deacetylase activity (H3-K18 specific)(GO:0097372)
0.0 0.1 GO:0005102 receptor binding(GO:0005102)
0.0 0.2 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.1 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)
0.0 0.6 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.0 GO:0031072 heat shock protein binding(GO:0031072)
0.0 0.3 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 0.2 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.1 GO:0008236 serine-type peptidase activity(GO:0008236)
0.0 0.3 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.0 0.3 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.1 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.1 GO:0019200 carbohydrate kinase activity(GO:0019200)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.7 PID FOXO PATHWAY FoxO family signaling
0.3 1.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.3 0.9 PID NOTCH PATHWAY Notch signaling pathway
0.1 0.4 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 0.2 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.1 127.3 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 0.2 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.1 0.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 0.2 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.1 PID ATR PATHWAY ATR signaling pathway
0.0 0.1 PID TELOMERASE PATHWAY Regulation of Telomerase

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.0 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.7 6.5 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.3 0.8 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.2 0.6 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.2 0.6 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 0.7 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 126.7 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 0.2 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 0.2 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.5 REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION Genes involved in Post-translational protein modification
0.0 0.2 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway