Results for HAP4
Z-value: 2.74
Motif logo
Transcription factors associated with HAP4
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
HAP4
|
S000001592 | Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YAL062W Show fit | 41.65 |
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources |
||
| YJR095W Show fit | 21.20 |
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization |
||
| YDR536W Show fit | 21.18 |
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock |
||
| YER065C Show fit | 20.96 |
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose |
||
| YNL052W Show fit | 18.47 |
Subunit Va of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth |
||
| YBL015W Show fit | 14.49 |
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth |
||
| YNR002C Show fit | 14.41 |
Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p |
||
| YBR117C Show fit | 13.71 |
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids |
||
| YJR078W Show fit | 13.63 |
Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p |
||
| YDL181W Show fit | 13.60 |
Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has similarity to Stf1p; has a calmodulin-binding motif and binds calmodulin in vitro |
Network of associatons between targets according to the STRING database.
First level regulatory network of HAP4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.7 | 79.1 | GO:0015986 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 4.3 | 47.5 | GO:0006119 | oxidative phosphorylation(GO:0006119) |
| 4.8 | 43.4 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 4.8 | 43.2 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 11.6 | 34.7 | GO:0019676 | ammonia assimilation cycle(GO:0019676) |
| 6.8 | 33.9 | GO:0006121 | mitochondrial electron transport, succinate to ubiquinone(GO:0006121) |
| 4.5 | 22.3 | GO:0015793 | glycerol transport(GO:0015793) |
| 1.6 | 20.5 | GO:0033617 | mitochondrial respiratory chain complex IV assembly(GO:0033617) |
| 6.6 | 19.9 | GO:0015740 | C4-dicarboxylate transport(GO:0015740) |
| 2.1 | 19.2 | GO:0006099 | tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 112.4 | GO:0005739 | mitochondrion(GO:0005739) |
| 5.8 | 51.8 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277) |
| 0.4 | 50.8 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 6.1 | 36.8 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263) |
| 6.8 | 33.9 | GO:0045273 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
| 3.6 | 32.3 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.4 | 29.5 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 1.5 | 26.2 | GO:0031306 | intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307) |
| 4.5 | 22.5 | GO:0000275 | mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261) |
| 6.6 | 19.8 | GO:0045265 | mitochondrial proton-transporting ATP synthase, stator stalk(GO:0000274) proton-transporting ATP synthase, stator stalk(GO:0045265) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.9 | 64.5 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 5.2 | 51.8 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 8.7 | 34.7 | GO:0016639 | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639) |
| 6.8 | 33.9 | GO:0008177 | succinate dehydrogenase (ubiquinone) activity(GO:0008177) |
| 4.0 | 32.3 | GO:0016679 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 5.2 | 26.1 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 3.0 | 21.0 | GO:0016833 | oxo-acid-lyase activity(GO:0016833) |
| 5.2 | 20.6 | GO:0005537 | mannose binding(GO:0005537) |
| 5.0 | 19.9 | GO:0015556 | C4-dicarboxylate transmembrane transporter activity(GO:0015556) |
| 2.4 | 19.5 | GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 147.4 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.8 | 7.3 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 2.0 | 6.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 1.5 | 4.5 | PID FOXO PATHWAY | FoxO family signaling |
| 1.3 | 4.0 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.4 | 1.8 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.4 | 1.4 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 0.1 | 0.3 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 0.2 | PID P73PATHWAY | p73 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 144.5 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 5.7 | 17.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 1.6 | 14.7 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 2.4 | 7.1 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 1.2 | 3.6 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 1.1 | 2.3 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |
| 0.2 | 2.2 | REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM | Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism |
| 0.5 | 1.9 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 1.1 | 1.1 | REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE | Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle |
| 0.2 | 0.7 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |