Navigation
Downloads

Results for HAP3

Z-value: 3.56

Motif logo

logo of

Transcription factors associated with HAP3

Gene Symbol Gene ID Gene Info
HAP3
S000000117 Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HAP3YBL021C0.741.5e-05Click!

Activity profile of HAP3 motif

Sorted Z-values of HAP3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YAL062W 56.74
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YLR174W 34.80
IDP2
Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
YML089C 30.99 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YBR201C-A 30.45 Putative protein of unknown function
YOR343C 28.28 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YDR536W 28.08
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YNL117W 22.45
MLS1
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YBR117C 22.34
TKL2
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YDL067C 21.28
COX9
Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YGL062W 20.65
PYC1
Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis
YML090W 19.64 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YJR078W 18.98
BNA2
Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p
YDR298C 18.53
ATP5
Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
YEL024W 18.35
RIP1
Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration
YKL038W 17.64
RGT1
Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor
YCR005C 17.58
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YOR382W 17.35
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YAL063C 16.96
FLO9
Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
YPR010C-A 16.58 Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YHL040C 15.83
ARN1
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores
YGR243W 15.49
FMP43
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YML091C 15.21
RPM2
Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
YMR256C 15.09
COX7
Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YBL030C 14.75
PET9
Major ADP/ATP carrier of the mitochondrial inner membrane, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; required for viability in many common lab strains carrying a mutation in the polymorphic SAL1 gene
YMR271C 14.57
URA10
Minor orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; major OPRTase encoded by URA5
YHR033W 14.15 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YOR376W 13.74 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.
YPL271W 12.98
ATP15
Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YDR148C 12.92
KGD2
Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
YER065C 12.80
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YJL166W 12.68
QCR8
Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
YJL116C 12.51
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YGL191W 12.48
COX13
Subunit VIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP
YNR002C 12.46
ATO2
Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p
YBL099W 12.18
ATP1
Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YKL085W 12.15
MDH1
Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated
YBL015W 12.05
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YNL052W 12.02
COX5A
Subunit Va of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth
YIR029W 12.02
DAL2
Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YDL204W 11.74
RTN2
Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily
YKR102W 11.61
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YGL187C 11.54
COX4
Subunit IV of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; N-terminal 25 residues of precursor are cleaved during mitochondrial import; phosphorylated
YBR051W 11.07 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase
YLR327C 10.92
TMA10
Protein of unknown function that associates with ribosomes
YBR050C 10.80
REG2
Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
YBL100C 10.59 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the 5' end of ATP1
YJL103C 10.40
GSM1
Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis
YML120C 10.36
NDI1
NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID
YHR001W-A 10.30
QCR10
Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain
YJR077C 10.16
MIR1
Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated
YJR149W 10.11 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YKR015C 10.05 Putative protein of unknown function
YDR377W 9.98
ATP17
Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YLL056C 9.86 Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene
YPL201C 9.72
YIG1
Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol
YDR529C 9.67
QCR7
Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly
YCL012C 9.60 Putative protein of unknown function; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene
YPL078C 9.58
ATP4
Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YIR039C 9.38
YPS6
Putative GPI-anchored aspartic protease
YDL181W 9.23
INH1
Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has similarity to Stf1p; has a calmodulin-binding motif and binds calmodulin in vitro
YLL055W 9.09
YCT1
High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
YGR144W 9.08
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YDL170W 9.08
UGA3
Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus
YER150W 8.99
SPI1
GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YKL141W 8.95
SDH3
Cytochrome b subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YEL008W 8.90 Hypothetical protein predicted to be involved in metabolism
YPR083W 8.82
MDM36
Protein required for normal mitochondrial morphology and inheritance
YFL011W 8.80
HXT10
Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YGR087C 8.69
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YDR505C 8.56
PSP1
Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition
YMR280C 8.55
CAT8
Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements
YLR395C 8.53
COX8
Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YOR186C-A 8.49 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YEL009C 8.49
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YKR067W 8.44
GPT2
Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis
YCL057C-A 8.38 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPL024W 8.21
RMI1
Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YMR206W 8.20 Putative protein of unknown function; YMR206W is not an essential gene
YPL262W 8.06
FUM1
Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation; phosphorylated in mitochondria
YBL066C 8.04
SEF1
Putative transcription factor, has homolog in Kluyveromyces lactis
YAL060W 8.03
BDH1
NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source
YFR053C 7.88
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YOR147W 7.88
MDM32
Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34
YBL045C 7.87
COR1
Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain
YAL067C 7.86
SEO1
Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
YLR304C 7.72
ACO1
Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy
YOL077W-A 7.54
ATP19
Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase
YLL041C 7.51
SDH2
Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YPL018W 7.48
CTF19
Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly
YMR017W 7.46
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YER014C-A 7.46
BUD25
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YPR015C 7.23 Putative protein of unknown function
YCR021C 7.21
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YJR151C 7.20
DAN4
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YML054C 7.12
CYB2
Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions
YJL102W 7.02
MEF2
Mitochondrial elongation factor involved in translational elongation
YBL065W 6.99 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene
YKR016W 6.90
AIM28
Protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss and severe growth defect in minimal glycerol media
YFL030W 6.88
AGX1
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YGR121C 6.86
MEP1
Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YFR049W 6.86
YMR31
Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36
YLL053C 6.84 Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YJL163C 6.75 Putative protein of unknown function
YHR008C 6.64
SOD2
Mitochondrial superoxide dismutase, protects cells against oxygen toxicity; phosphorylated
YPL026C 6.63
SKS1
Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YKR066C 6.41
CCP1
Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress
YFR033C 6.40
QCR6
Subunit 6 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1
YBR292C 6.40 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
YPR065W 6.26
ROX1
Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity
YMR165C 6.26
PAH1
Mg2+-dependent phosphatidate (PA) phosphatase, catalyzes the dephosphorylation of PA to yield diacylglycerol and Pi, responsible for de novo lipid synthesis; homologous to mammalian lipin 1
YPL200W 6.25
CSM4
Protein required for accurate chromosome segregation during meiosis
YPR020W 6.23
ATP20
Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex
YBR039W 6.22
ATP3
Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YDR036C 6.19
EHD3
3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis
YNR069C 6.14
BSC5
Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
YLL052C 6.13
AQY2
Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YFL051C 6.12 Putative protein of unknown function; YFL051C is not an essential gene
YBR218C 6.08
PYC2
Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosis
YHR092C 5.89
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YGL114W 5.88 Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YBR284W 5.86 Putative protein of unknown function; YBR284W is not an essential gene; null mutant exhibits decreased resistance to rapamycin and wortmannin
YOR378W 5.74 Putative protein of unknown function; belongs to the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
YPR082C 5.66
DIB1
17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein
YPL183W-A 5.64
RTC6
Homolog of the prokaryotic ribosomal protein L36, likely to be a mitochondrial ribosomal protein coded in the nuclear genome; null mutation suppresses cdc13-1 temperature sensitivity
YDR216W 5.55
ADR1
Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
YJL199C 5.50
MBB1
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies
YKL016C 5.48
ATP7
Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YPL092W 5.46
SSU1
Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein
YDR178W 5.43
SDH4
Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YJR154W 5.35 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YGR088W 5.32
CTT1
Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YDR476C 5.31 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene
YMR107W 5.28
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YMR118C 5.27 Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene
YLL019C 5.10
KNS1
Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues
YFL052W 5.07 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YGR053C 5.06 Putative protein of unknown function
YDL140C 4.89
RPO21
RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
YPR154W 4.89
PIN3
Protein that induces appearance of [PIN+] prion when overproduced
YOR152C 4.84 Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YIL162W 4.82
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YPL250C 4.74
ICY2
Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YOR211C 4.72
MGM1
Mitochondrial GTPase related to dynamin, present in a complex containing Ugo1p and Fzo1p; required for normal morphology of cristae and for stability of Tim11p; homolog of human OPA1 involved in autosomal dominant optic atrophy
YLR189C 4.72
ATG26
UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy
YDL066W 4.71
IDP1
Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
YMR145C 4.67
NDE1
Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain
YAL034C 4.61
FUN19
Non-essential protein of unknown function
YPR193C 4.56
HPA2
Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity
YPL272C 4.56 Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene
YJR095W 4.54
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YGL136C 4.50
MRM2
Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ
YLL057C 4.43
JLP1
Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)
YMR194C-B 4.37 Putative protein of unknown function
YOR065W 4.36
CYT1
Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
YGR286C 4.33
BIO2
Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant
YKL010C 4.27
UFD4
Ubiquitin-protein ligase (E3) that interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins
YEL070W 4.25
DSF1
Deletion suppressor of mpt5 mutation
YKR049C 4.17
FMP46
Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKL177W 4.14 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene STE3
YDL174C 4.14
DLD1
D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
YJR080C 4.10
AIM24
Protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays increased frequency of mitochondrial genome loss and reduced growth rate in minimal glycerol media
YPL058C 3.96
PDR12
Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity
YER098W 3.92
UBP9
Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions
YIL059C 3.90 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W
YKR009C 3.90
FOX2
Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
YDR231C 3.89
COX20
Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
YFR010W-A 3.89 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized gene YFR011C; identified by expression profiling and mass spectrometry
YBR077C 3.88
SLM4
Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
YLR267W 3.87
BOP2
Protein of unknown function, overproduction suppresses a pam1 slv3 double null mutation
YLR438W 3.86
CAR2
L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive
YPL230W 3.81
USV1
Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in protein folding, ATP binding, and cell wall biosynthesis
YAR050W 3.79
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YNL242W 3.77
ATG2
Peripheral membrane protein required for vesicle formation during autophagy, pexophagy, and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the pre-autophagosomal structure and mitochondria
YBR293W 3.75
VBA2
Permease of basic amino acids in the vacuolar membrane
YDR171W 3.72
HSP42
Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock
YFR047C 3.67
BNA6
Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
YHL041W 3.65 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YNL180C 3.63
RHO5
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
YJL213W 3.61 Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p
YPL135W 3.58
ISU1
Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable
YER066W 3.56 Putative protein of unknown function; YER066W is not an essential gene
YBR250W 3.52
SPO23
Protein of unknown function; associates with meiosis-specific protein Spo1p
YPR064W 3.45 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YGR268C 3.43
HUA1
Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
YDL004W 3.43
ATP16
Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YDL104C 3.37
QRI7
Putative metalloprotease, similar to O-sialoglycoprotein metallopeptidase from P. haemolytica; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBR033W 3.35
EDS1
Putative zinc cluster protein; YBR033W is not an essential gene
YGR226C 3.35 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W
YNL179C 3.34 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
YBR296C 3.32
PHO89
Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
YOL082W 3.31
ATG19
Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; recognizes cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) and delivers them to the preautophagosomal structure for packaging into Cvt vesicles
YLR228C 3.30
ECM22
Sterol regulatory element binding protein, regulates transcription of the sterol biosynthetic genes ERG2 and ERG3; member of the fungus-specific Zn[2]-Cys[6] binuclear cluster family of transcription factors; homologous to Upc2p
YNR001C 3.25
CIT1
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein
YLR437C-A 3.22 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CAR2/YLR438W
YDR322C-A 3.21
TIM11
Subunit e of mitochondrial F1F0-ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthase
YOL058W 3.20
ARG1
Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate
YOR285W 3.16 Protein of unknown function, localized to the mitochondrial outer membrane
YGR067C 3.15 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YKL178C 3.14
STE3
Receptor for a factor receptor, transcribed in alpha cells and required for mating by alpha cells, couples to MAP kinase cascade to mediate pheromone response; ligand bound receptors are endocytosed and recycled to the plasma membrane; GPCR
YPR196W 3.13 Putative maltose activator

Network of associatons between targets according to the STRING database.

First level regulatory network of HAP3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
12.2 36.7 GO:0019676 ammonia assimilation cycle(GO:0019676)
11.1 100.3 GO:0006097 glyoxylate cycle(GO:0006097)
8.0 63.9 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
7.6 68.5 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
7.1 99.3 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
6.4 19.3 GO:0032780 negative regulation of ATPase activity(GO:0032780)
6.4 25.5 GO:0046323 glucose import(GO:0046323)
5.6 44.9 GO:0006119 oxidative phosphorylation(GO:0006119)
5.4 32.4 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
5.2 26.1 GO:0015793 glycerol transport(GO:0015793)
4.8 14.5 GO:0006850 mitochondrial pyruvate transport(GO:0006850)
4.6 18.4 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
4.5 22.6 GO:0034627 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
4.4 35.1 GO:0015891 siderophore transport(GO:0015891)
4.1 16.2 GO:0015886 heme transport(GO:0015886)
4.0 12.1 GO:0006108 malate metabolic process(GO:0006108)
3.9 11.7 GO:0042744 hydrogen peroxide metabolic process(GO:0042743) hydrogen peroxide catabolic process(GO:0042744)
3.5 20.8 GO:0090294 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
2.8 13.8 GO:0000255 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256)
2.7 8.0 GO:0000101 sulfur amino acid transport(GO:0000101)
2.4 12.0 GO:0006083 acetate metabolic process(GO:0006083)
2.3 6.9 GO:0006545 glycine biosynthetic process(GO:0006545)
2.3 6.9 GO:0072488 ammonium transmembrane transport(GO:0072488)
2.2 11.1 GO:0043954 cellular component maintenance(GO:0043954)
2.2 6.6 GO:0019401 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
2.2 8.7 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
2.2 6.5 GO:0001315 age-dependent response to reactive oxygen species(GO:0001315) cellular age-dependent response to reactive oxygen species(GO:0072353)
2.2 13.0 GO:0044205 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
2.1 6.3 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
2.1 8.2 GO:0051101 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
1.9 7.7 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
1.8 5.5 GO:0046321 ethanol catabolic process(GO:0006068) regulation of fatty acid beta-oxidation(GO:0031998) positive regulation of fatty acid beta-oxidation(GO:0032000) primary alcohol catabolic process(GO:0034310) regulation of fatty acid oxidation(GO:0046320) positive regulation of fatty acid oxidation(GO:0046321)
1.6 15.7 GO:0072350 tricarboxylic acid metabolic process(GO:0072350)
1.6 6.3 GO:0090220 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
1.5 4.6 GO:0015888 thiamine transport(GO:0015888)
1.5 10.7 GO:0000266 mitochondrial fission(GO:0000266)
1.5 6.0 GO:0034389 lipid particle organization(GO:0034389)
1.5 22.0 GO:0006098 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
1.4 1.4 GO:0043902 positive regulation of multi-organism process(GO:0043902)
1.3 10.1 GO:0006635 fatty acid beta-oxidation(GO:0006635)
1.2 4.9 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) negative regulation of actin nucleation(GO:0051126)
1.2 7.1 GO:0006089 lactate metabolic process(GO:0006089)
1.2 3.5 GO:0015740 C4-dicarboxylate transport(GO:0015740)
1.1 4.5 GO:0006527 arginine catabolic process(GO:0006527)
1.1 1.1 GO:0006559 L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
1.0 3.0 GO:2000284 positive regulation of cellular amino acid biosynthetic process(GO:2000284)
1.0 3.0 GO:0042407 cristae formation(GO:0042407)
1.0 3.0 GO:0017003 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
1.0 11.7 GO:0019740 nitrogen utilization(GO:0019740)
1.0 1.9 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.9 4.7 GO:0008053 mitochondrial fusion(GO:0008053)
0.9 4.6 GO:0051260 protein homooligomerization(GO:0051260)
0.8 29.4 GO:0009060 aerobic respiration(GO:0009060)
0.8 7.5 GO:0072348 sulfur compound transport(GO:0072348)
0.8 3.3 GO:0035969 regulation of steroid metabolic process(GO:0019218) positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) regulation of ergosterol biosynthetic process(GO:0032443) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of steroid biosynthetic process(GO:0050810) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.8 4.0 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.8 2.4 GO:0006000 fructose metabolic process(GO:0006000)
0.8 2.4 GO:0031055 chromatin remodeling at centromere(GO:0031055)
0.8 11.7 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.7 19.9 GO:0006094 gluconeogenesis(GO:0006094)
0.7 2.9 GO:0019405 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.7 14.5 GO:0015749 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.7 4.3 GO:0060238 regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion(GO:0010969) regulation of signal transduction involved in conjugation with cellular fusion(GO:0060238)
0.6 5.2 GO:0005987 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.6 10.8 GO:0042724 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.6 1.8 GO:0006343 establishment of chromatin silencing(GO:0006343)
0.6 4.8 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.6 2.4 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.6 2.3 GO:0031507 heterochromatin assembly(GO:0031507)
0.6 2.3 GO:0036498 mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response(GO:0030969) IRE1-mediated unfolded protein response(GO:0036498) mRNA splicing, via endonucleolytic cleavage and ligation(GO:0070054)
0.6 7.5 GO:0034087 establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087)
0.6 5.0 GO:0046173 polyol biosynthetic process(GO:0046173)
0.5 5.8 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.5 1.6 GO:0006827 high-affinity iron ion transmembrane transport(GO:0006827)
0.5 4.8 GO:0015802 basic amino acid transport(GO:0015802)
0.5 5.2 GO:0006817 phosphate ion transport(GO:0006817)
0.5 1.4 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.5 2.3 GO:0044746 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.5 4.1 GO:0031167 rRNA methylation(GO:0031167)
0.4 1.8 GO:0061393 positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress(GO:0061393)
0.4 2.2 GO:0000023 maltose metabolic process(GO:0000023)
0.4 0.4 GO:0001178 regulation of transcriptional start site selection at RNA polymerase II promoter(GO:0001178)
0.4 1.3 GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000448)
0.4 2.5 GO:0051177 meiotic sister chromatid cohesion(GO:0051177)
0.4 0.8 GO:0044783 G1 DNA damage checkpoint(GO:0044783)
0.4 3.3 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.4 1.7 GO:0071467 response to alkaline pH(GO:0010446) cellular response to pH(GO:0071467) cellular response to alkaline pH(GO:0071469)
0.4 0.8 GO:0043901 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.4 9.1 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.4 6.2 GO:0001300 chronological cell aging(GO:0001300)
0.4 3.1 GO:0000755 cytogamy(GO:0000755)
0.4 5.8 GO:0001101 response to acid chemical(GO:0001101)
0.4 3.0 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.4 3.6 GO:0034204 lipid translocation(GO:0034204) regulation of membrane lipid distribution(GO:0097035)
0.4 4.3 GO:0006839 mitochondrial transport(GO:0006839)
0.4 2.2 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.4 4.7 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.3 1.4 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.3 5.5 GO:0006513 protein monoubiquitination(GO:0006513)
0.3 2.0 GO:0032978 protein insertion into membrane from inner side(GO:0032978) protein insertion into mitochondrial membrane from inner side(GO:0032979)
0.3 0.6 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.3 1.0 GO:2001247 positive regulation of phosphatidylcholine biosynthetic process(GO:2001247)
0.3 1.2 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.3 1.5 GO:0032102 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.3 0.9 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.3 2.8 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.3 0.3 GO:0042542 response to hydrogen peroxide(GO:0042542)
0.3 0.8 GO:0032365 intracellular lipid transport(GO:0032365)
0.3 1.9 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.3 1.0 GO:0071041 antisense RNA transcript catabolic process(GO:0071041)
0.3 0.8 GO:0052547 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
0.2 0.7 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.2 1.6 GO:0006855 drug transmembrane transport(GO:0006855)
0.2 0.5 GO:0010507 negative regulation of autophagy(GO:0010507)
0.2 2.0 GO:0006829 zinc II ion transport(GO:0006829)
0.2 0.4 GO:0000957 mitochondrial RNA catabolic process(GO:0000957)
0.2 1.3 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.2 1.3 GO:0019933 cAMP-mediated signaling(GO:0019933) cyclic-nucleotide-mediated signaling(GO:0019935)
0.2 0.2 GO:0030048 actin filament-based movement(GO:0030048) actin filament-based transport(GO:0099515)
0.2 1.2 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.2 1.8 GO:0015914 phospholipid transport(GO:0015914)
0.2 3.5 GO:0016579 protein deubiquitination(GO:0016579)
0.2 1.2 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.2 0.5 GO:1901800 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of mitotic nuclear division(GO:0045840) positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of proteolysis(GO:0045862) positive regulation of chromosome segregation(GO:0051984) positive regulation of proteasomal protein catabolic process(GO:1901800) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101) positive regulation of proteolysis involved in cellular protein catabolic process(GO:1903052) positive regulation of cellular protein catabolic process(GO:1903364) positive regulation of ubiquitin protein ligase activity(GO:1904668) regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.2 0.8 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.2 2.7 GO:0006915 apoptotic process(GO:0006915) cell death(GO:0008219) programmed cell death(GO:0012501)
0.1 0.3 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.1 0.8 GO:0016239 positive regulation of macroautophagy(GO:0016239) regulation of macroautophagy(GO:0016241)
0.1 0.6 GO:0045033 peroxisome inheritance(GO:0045033)
0.1 1.0 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 0.7 GO:0070124 mitochondrial translational initiation(GO:0070124)
0.1 0.6 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.1 1.1 GO:0006077 (1->6)-beta-D-glucan metabolic process(GO:0006077)
0.1 0.4 GO:0072417 cellular response to biotic stimulus(GO:0071216) response to cell cycle checkpoint signaling(GO:0072396) response to mitotic cell cycle checkpoint signaling(GO:0072414) response to spindle checkpoint signaling(GO:0072417) response to mitotic spindle checkpoint signaling(GO:0072476) response to mitotic cell cycle spindle assembly checkpoint signaling(GO:0072479) response to spindle assembly checkpoint signaling(GO:0072485) negative regulation of protein import into nucleus during spindle assembly checkpoint(GO:1901925)
0.1 0.6 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.1 0.9 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.1 2.1 GO:0045143 homologous chromosome segregation(GO:0045143)
0.1 1.1 GO:0045910 negative regulation of DNA recombination(GO:0045910)
0.1 0.5 GO:0000729 meiotic DNA double-strand break processing(GO:0000706) DNA double-strand break processing(GO:0000729)
0.1 0.4 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.1 2.3 GO:0031503 protein complex localization(GO:0031503)
0.1 2.2 GO:0007117 budding cell bud growth(GO:0007117)
0.1 0.3 GO:0031062 positive regulation of histone methylation(GO:0031062) regulation of histone H3-K4 methylation(GO:0051569)
0.1 0.5 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.1 2.4 GO:0006312 mitotic recombination(GO:0006312)
0.1 2.6 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.1 0.2 GO:2001040 cellular response to drug(GO:0035690) regulation of response to drug(GO:2001023) positive regulation of response to drug(GO:2001025) regulation of cellular response to drug(GO:2001038) positive regulation of cellular response to drug(GO:2001040)
0.1 0.8 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.1 0.5 GO:0001041 transcription from RNA polymerase III type 2 promoter(GO:0001009) transcription from a RNA polymerase III hybrid type promoter(GO:0001041)
0.1 14.8 GO:0007005 mitochondrion organization(GO:0007005)
0.1 0.5 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.1 0.1 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.1 0.6 GO:0046834 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.1 0.2 GO:0030100 regulation of endocytosis(GO:0030100)
0.1 0.1 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.1 0.4 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.1 0.4 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 0.2 GO:0000751 mitotic cell cycle arrest in response to pheromone(GO:0000751) mitotic cell cycle arrest(GO:0071850)
0.0 0.7 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 0.3 GO:0009231 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.0 0.2 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.0 0.1 GO:0015893 drug transport(GO:0015893)
0.0 0.4 GO:0016180 snRNA processing(GO:0016180) DNA-dependent DNA replication maintenance of fidelity(GO:0045005)
0.0 0.5 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 0.4 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.1 GO:0045991 carbon catabolite activation of transcription(GO:0045991)
0.0 0.2 GO:0042766 nucleosome mobilization(GO:0042766)
0.0 0.1 GO:0019321 pentose metabolic process(GO:0019321) pentose catabolic process(GO:0019323)
0.0 0.4 GO:0035825 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 0.3 GO:0000282 cellular bud site selection(GO:0000282) mitotic cytokinesis, site selection(GO:1902408)
0.0 0.1 GO:0090114 COPII-coated vesicle budding(GO:0090114)
0.0 0.1 GO:0000132 establishment of mitotic spindle orientation(GO:0000132) establishment of mitotic spindle localization(GO:0040001) establishment of spindle orientation(GO:0051294)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
11.2 33.6 GO:0000274 mitochondrial proton-transporting ATP synthase, stator stalk(GO:0000274) proton-transporting ATP synthase, stator stalk(GO:0045265)
9.0 80.9 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
8.0 71.8 GO:0070069 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) cytochrome complex(GO:0070069)
7.5 22.6 GO:0045269 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
6.1 18.4 GO:0009353 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
6.1 12.2 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
5.1 30.9 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
4.8 24.2 GO:0098803 mitochondrial respiratory chain(GO:0005746) respiratory chain complex(GO:0098803)
2.9 2.9 GO:0045259 mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259)
2.9 8.7 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
2.7 8.2 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
2.4 4.7 GO:0030061 mitochondrial crista(GO:0030061)
1.9 22.5 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
1.9 7.5 GO:0000817 COMA complex(GO:0000817)
1.8 7.1 GO:0070469 respiratory chain(GO:0070469)
1.5 11.7 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
1.2 60.4 GO:0031225 anchored component of membrane(GO:0031225)
1.1 10.6 GO:0030677 ribonuclease P complex(GO:0030677)
1.0 3.0 GO:0044284 mitochondrial crista junction(GO:0044284)
0.7 12.4 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.7 3.4 GO:0034448 EGO complex(GO:0034448)
0.6 1.2 GO:0001400 mating projection base(GO:0001400)
0.6 9.2 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304)
0.5 8.7 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.5 2.2 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.5 2.0 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.5 1.4 GO:0035649 Nrd1 complex(GO:0035649)
0.4 61.9 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.4 6.2 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.4 1.3 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.4 14.4 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.4 1.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.3 0.9 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.3 2.8 GO:0000795 synaptonemal complex(GO:0000795)
0.3 0.8 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.3 4.1 GO:0005682 U5 snRNP(GO:0005682)
0.3 1.6 GO:0033101 cellular bud membrane(GO:0033101)
0.3 1.8 GO:0005677 chromatin silencing complex(GO:0005677)
0.2 13.7 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.2 17.5 GO:0010008 endosome membrane(GO:0010008)
0.2 3.4 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.2 0.9 GO:0033551 monopolin complex(GO:0033551)
0.2 2.9 GO:0005576 extracellular region(GO:0005576)
0.2 4.4 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.2 0.7 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.2 5.1 GO:0042764 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.2 133.7 GO:0005739 mitochondrion(GO:0005739)
0.2 2.4 GO:0000812 Swr1 complex(GO:0000812)
0.2 1.1 GO:0035267 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.2 0.7 GO:0070775 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.2 0.8 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.2 1.4 GO:0005619 ascospore wall(GO:0005619) spore wall(GO:0031160)
0.2 3.6 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.2 3.8 GO:0005887 integral component of plasma membrane(GO:0005887)
0.2 3.5 GO:0030312 cell wall(GO:0005618) external encapsulating structure(GO:0030312)
0.1 2.8 GO:0005811 lipid particle(GO:0005811)
0.1 0.4 GO:0033186 CAF-1 complex(GO:0033186)
0.1 0.8 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 5.3 GO:0061645 actin cortical patch(GO:0030479) endocytic patch(GO:0061645)
0.1 3.7 GO:0019898 extrinsic component of membrane(GO:0019898)
0.1 0.6 GO:0005769 early endosome(GO:0005769)
0.1 0.6 GO:0034967 Set3 complex(GO:0034967)
0.1 2.3 GO:0044459 plasma membrane part(GO:0044459)
0.1 0.6 GO:0031499 TRAMP complex(GO:0031499)
0.1 0.5 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.1 0.9 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 18.3 GO:0005886 plasma membrane(GO:0005886)
0.0 0.8 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 3.1 GO:0000790 nuclear chromatin(GO:0000790)
0.0 0.4 GO:0016514 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.0 0.5 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 1.4 GO:0000779 condensed chromosome, centromeric region(GO:0000779)
0.0 0.9 GO:0000922 spindle pole(GO:0000922)
0.0 0.2 GO:0034399 nuclear periphery(GO:0034399)
0.0 0.2 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
13.2 39.5 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
9.2 36.7 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
8.4 67.4 GO:0016679 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
8.1 80.9 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
8.1 32.4 GO:0005537 mannose binding(GO:0005537)
7.3 80.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
6.9 20.8 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
6.3 25.1 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
6.1 18.2 GO:0016289 CoA hydrolase activity(GO:0016289)
5.6 28.1 GO:0015295 solute:proton symporter activity(GO:0015295)
5.0 15.0 GO:0008137 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
4.8 14.5 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
4.8 24.2 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
4.7 18.9 GO:0015343 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
4.2 12.7 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
4.0 12.1 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
3.7 14.7 GO:0005471 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
3.4 20.3 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
3.1 25.1 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
3.0 23.6 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
2.8 11.3 GO:0016898 lactate dehydrogenase activity(GO:0004457) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
2.6 13.1 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
2.5 12.7 GO:0008198 ferrous iron binding(GO:0008198)
2.2 8.7 GO:0004396 hexokinase activity(GO:0004396)
2.2 8.7 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
2.0 7.9 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
1.8 1.8 GO:0004075 biotin carboxylase activity(GO:0004075)
1.6 4.8 GO:0004575 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
1.6 8.0 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
1.6 10.9 GO:0016833 oxo-acid-lyase activity(GO:0016833)
1.5 5.9 GO:0016417 S-acyltransferase activity(GO:0016417)
1.5 19.0 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
1.4 27.4 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
1.4 5.7 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
1.4 5.5 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
1.4 8.2 GO:0000400 four-way junction DNA binding(GO:0000400)
1.3 3.9 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
1.2 8.4 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
1.2 18.0 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
1.2 3.5 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
1.1 2.2 GO:0042947 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
1.1 10.6 GO:0004526 ribonuclease P activity(GO:0004526)
1.1 12.7 GO:0022838 substrate-specific channel activity(GO:0022838)
1.0 3.1 GO:0004930 G-protein coupled receptor activity(GO:0004930)
1.0 16.6 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.9 4.5 GO:0008171 O-methyltransferase activity(GO:0008171)
0.9 2.7 GO:0033549 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.9 4.3 GO:0016783 sulfurtransferase activity(GO:0016783)
0.8 2.4 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.8 11.5 GO:0046906 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.8 3.8 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.8 6.0 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.7 6.5 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.7 2.2 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.7 8.4 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.7 2.1 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
0.6 5.6 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.6 4.8 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.6 2.4 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.6 7.9 GO:0015578 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.5 6.5 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.5 9.8 GO:0016769 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.5 1.4 GO:0016872 intramolecular lyase activity(GO:0016872)
0.5 1.4 GO:0015385 sodium:proton antiporter activity(GO:0015385)
0.5 12.8 GO:0004857 enzyme inhibitor activity(GO:0004857)
0.4 1.3 GO:0008169 C-methyltransferase activity(GO:0008169)
0.4 2.2 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.4 1.8 GO:0016531 copper chaperone activity(GO:0016531)
0.4 1.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.4 4.1 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.4 2.4 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.4 17.4 GO:0001228 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.4 1.1 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.4 2.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.4 1.4 GO:0005186 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.3 3.1 GO:0000293 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.3 0.9 GO:0005302 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.3 2.8 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.3 0.6 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.3 2.5 GO:0038023 transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) transmembrane receptor activity(GO:0099600)
0.3 1.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.3 2.9 GO:0043495 protein anchor(GO:0043495)
0.3 0.5 GO:0045118 azole transporter activity(GO:0045118)
0.2 3.9 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.2 0.9 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.2 4.2 GO:0004221 obsolete ubiquitin thiolesterase activity(GO:0004221) thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.2 0.6 GO:0008972 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.2 16.2 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.2 2.8 GO:0003746 translation elongation factor activity(GO:0003746)
0.2 0.9 GO:0070403 NAD+ binding(GO:0070403)
0.2 0.5 GO:0051880 double-stranded telomeric DNA binding(GO:0003691) G-quadruplex DNA binding(GO:0051880)
0.2 1.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.2 0.5 GO:0055106 cyclin binding(GO:0030332) ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106) ubiquitin-protein transferase activator activity(GO:0097027)
0.2 1.5 GO:0035064 methylated histone binding(GO:0035064)
0.2 1.0 GO:0005548 phospholipid transporter activity(GO:0005548)
0.2 0.9 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.1 0.7 GO:0019104 DNA N-glycosylase activity(GO:0019104)
0.1 3.0 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 0.8 GO:0015297 antiporter activity(GO:0015297)
0.1 0.4 GO:0046527 glucosyltransferase activity(GO:0046527)
0.1 0.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 0.6 GO:0003993 acid phosphatase activity(GO:0003993)
0.1 0.6 GO:0015293 symporter activity(GO:0015293)
0.1 0.6 GO:0031072 heat shock protein binding(GO:0031072)
0.1 0.8 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.1 0.4 GO:0070717 poly(A) binding(GO:0008143) poly-purine tract binding(GO:0070717)
0.1 0.7 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.1 0.5 GO:0008106 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.1 0.8 GO:0001055 RNA polymerase II activity(GO:0001055)
0.1 0.5 GO:0001005 RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003) transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting(GO:0001004) transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIB recruiting(GO:0001005) transcription factor activity, RNA polymerase III type 2 promoter sequence-specific binding, TFIIIB recruiting(GO:0001008) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034)
0.1 0.3 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 0.7 GO:1901505 carbohydrate derivative transporter activity(GO:1901505)
0.1 0.9 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 1.5 GO:0004402 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.1 0.2 GO:0070336 flap-structured DNA binding(GO:0070336)
0.1 0.9 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.1 3.2 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
0.1 0.3 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.1 0.4 GO:0016896 exoribonuclease activity(GO:0004532) exoribonuclease activity, producing 5'-phosphomonoesters(GO:0016896)
0.1 0.2 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.9 GO:0016830 carbon-carbon lyase activity(GO:0016830)
0.0 0.1 GO:0001129 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132)
0.0 0.4 GO:0031386 protein tag(GO:0031386)
0.0 0.1 GO:0032183 SUMO binding(GO:0032183)
0.0 0.4 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.3 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 0.4 GO:0019904 protein domain specific binding(GO:0019904)
0.0 0.8 GO:0005509 calcium ion binding(GO:0005509)
0.0 1.4 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.1 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.0 0.4 GO:0008236 serine-type peptidase activity(GO:0008236)
0.0 0.2 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 1.2 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616)
0.0 0.5 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.0 0.0 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.0 0.0 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.0 0.2 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.0 0.0 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037) glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.3 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.1 GO:0004364 glutathione transferase activity(GO:0004364)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 12.2 PID IL4 2PATHWAY IL4-mediated signaling events
2.7 8.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
2.2 6.6 PID FOXO PATHWAY FoxO family signaling
0.8 7.3 PID FANCONI PATHWAY Fanconi anemia pathway
0.6 1.9 PID NOTCH PATHWAY Notch signaling pathway
0.6 1.7 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.5 0.5 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.5 1.9 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.4 1.3 PID CMYB PATHWAY C-MYB transcription factor network
0.1 144.4 PID IFNG PATHWAY IFN-gamma pathway
0.1 0.1 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 12.0 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
1.5 13.9 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
1.5 13.4 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.8 2.5 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.6 1.9 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.6 0.6 REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT Genes involved in The citric acid (TCA) cycle and respiratory electron transport
0.2 3.1 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.2 0.7 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.2 0.5 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 0.5 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 0.8 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.1 1.5 REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.1 144.4 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 0.2 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane