Results for HAP2
Z-value: 1.02
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Transcription factors associated with HAP2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
HAP2
|
S000003206 | Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YKL096W-A Show fit | 3.81 |
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored |
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| YNL300W Show fit | 3.44 |
Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid |
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| YDR044W Show fit | 3.24 |
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p) |
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| YKR013W Show fit | 3.22 |
Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins |
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| YFR055W Show fit | 3.08 |
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner |
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| YOR247W Show fit | 3.02 |
Mannoprotein that exhibits a tight association with the cell wall, required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants |
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| YKR012C Show fit | 2.84 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2 |
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| YDR384C Show fit | 2.70 |
Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters |
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| YGL255W Show fit | 2.66 |
High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor |
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| YHR181W Show fit | 2.63 |
Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment |
Network of associatons between targets according to the STRING database.
First level regulatory network of HAP2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 23.2 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.4 | 6.0 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.8 | 5.9 | GO:0006782 | protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501) |
| 0.3 | 5.6 | GO:0015918 | sterol transport(GO:0015918) |
| 0.5 | 5.4 | GO:0006817 | phosphate ion transport(GO:0006817) |
| 0.3 | 5.3 | GO:0006407 | rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029) |
| 0.0 | 5.0 | GO:0006364 | rRNA processing(GO:0006364) |
| 0.5 | 4.8 | GO:0006829 | zinc II ion transport(GO:0006829) |
| 0.2 | 4.7 | GO:0006096 | glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757) |
| 0.2 | 4.1 | GO:0006885 | regulation of pH(GO:0006885) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 21.4 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.3 | 19.5 | GO:0005576 | extracellular region(GO:0005576) |
| 0.3 | 16.0 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.3 | 8.1 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.2 | 6.9 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 0.0 | 6.5 | GO:0005730 | nucleolus(GO:0005730) |
| 0.0 | 6.2 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.1 | 5.0 | GO:0044445 | cytosolic part(GO:0044445) |
| 0.2 | 4.1 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 4.0 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 32.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.6 | 6.8 | GO:0005199 | structural constituent of cell wall(GO:0005199) |
| 0.2 | 6.2 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.7 | 4.7 | GO:0015665 | alcohol transmembrane transporter activity(GO:0015665) |
| 0.1 | 4.3 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
| 0.4 | 4.0 | GO:0005496 | steroid binding(GO:0005496) sterol binding(GO:0032934) |
| 0.5 | 3.7 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.2 | 3.5 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.1 | 3.4 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.8 | 3.3 | GO:0016634 | oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 0.9 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.2 | 0.8 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.2 | 0.7 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 0.4 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.1 | 0.2 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 0.2 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 0.2 | PID FGF PATHWAY | FGF signaling pathway |
| 0.1 | 0.1 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.1 | 0.1 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.1 | 0.1 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.0 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 0.4 | 3.3 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 0.4 | 1.7 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.4 | 1.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 0.8 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 0.8 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.1 | 0.4 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.1 | 0.4 | REACTOME SIGNALING BY INSULIN RECEPTOR | Genes involved in Signaling by Insulin receptor |
| 0.1 | 0.4 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.0 | 0.4 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |