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Results for HAP1

Z-value: 1.05

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Transcription factors associated with HAP1

Gene Symbol Gene ID Gene Info
HAP1
S000004246 Transcription factor involved in response to levels of heme and oxygen

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HAP1YLR256W-0.358.2e-02Click!

Activity profile of HAP1 motif

Sorted Z-values of HAP1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YLR154W-B 5.14 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YLR154W-A 5.11 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YKL096W-A 3.32
CWP2
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YLR110C 2.98
CCW12
Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor
YER131W 2.78
RPS26B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YLR154C 2.66
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YDR033W 2.30
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YPL028W 2.25
ERG10
Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis
YJR105W 2.13
ADO1
Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
YGR280C 1.97
PXR1
Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain
YOL086C 1.71
ADH1
Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YPL014W 1.71 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
YDR508C 1.69
GNP1
High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids
YPR063C 1.68 ER-localized protein of unknown function
YDL205C 1.62
HEM3
Phorphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p
YDR509W 1.61 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YML028W 1.47
TSA1
Thioredoxin peroxidase, acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype
YGR176W 1.46 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL182W 1.43
FAS1
Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
YDR112W 1.32
IRC2
Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci
YGL012W 1.30
ERG4
C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol
YLR206W 1.27
ENT2
Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
YNR043W 1.24
MVD1
Mevalonate pyrophosphate decarboxylase, essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer
YOL120C 1.24
RPL18A
Protein component of the large (60S) ribosomal subunit, identical to Rpl18Bp and has similarity to rat L18 ribosomal protein; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation
YGL255W 1.23
ZRT1
High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YOL085C 1.20 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A
YNL178W 1.20
RPS3
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YJL048C 1.18
UBX6
UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline
YDR111C 1.16
ALT2
Putative alanine transaminase (glutamic pyruvic transaminase)
YLR109W 1.16
AHP1
Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p
YIL039W 1.15
TED1
Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YBR210W 1.14
ERV15
Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p
YBR149W 1.12
ARA1
NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product
YER146W 1.10
LSM5
Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YHR136C 1.09
SPL2
Protein with similarity to cyclin-dependent kinase inhibitors, overproduction suppresses a plc1 null mutation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YPR157W 1.08 Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YER003C 1.06
PMI40
Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation
YNR042W 1.04 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
YCR018C 1.02
SRD1
Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YDR047W 1.02
HEM12
Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; activity inhibited by Cu2+, Zn2+, Fe2+, Fe3+ and sulfhydryl-specific reagents
YMR008C 1.01
PLB1
Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
YDR046C 0.99
BAP3
Amino acid permease involved in the uptake of cysteine, leucine, isoleucine and valine
YMR009W 0.98
ADI1
Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions
YDR037W 0.96
KRS1
Lysyl-tRNA synthetase; also identified as a negative regulator of general control of amino acid biosynthesis
YGR175C 0.96
ERG1
Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine
YCR006C 0.96 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL051W 0.95
SFK1
Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
YNR067C 0.94
DSE4
Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother
YNR041C 0.93
COQ2
Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
YDR133C 0.92 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YJR069C 0.89
HAM1
Conserved protein with deoxyribonucleoside triphosphate pyrophosphohydrolase activity, mediates exclusion of noncanonical purines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine
YHR190W 0.89
ERG9
Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway
YBL006C 0.85
LDB7
Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
YOR095C 0.85
RKI1
Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis
YOR356W 0.85 Mitochondrial protein with similarity to flavoprotein-type oxidoreductases; found in a large supramolecular complex with other mitochondrial dehydrogenases
YOR317W 0.85
FAA1
Long chain fatty acyl-CoA synthetase with a preference for C12:0-C16:0 fatty acids; involved in the activation of imported fatty acids; localized to both lipid particles and mitochondrial outer membrane; essential for stationary phase
YGR249W 0.84
MGA1
Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants
YMR001C-A 0.83 Putative protein of unknown function
YJL026C-A 0.83 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL026W/RNR2
YDR032C 0.82
PST2
Protein with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKL019W 0.82
RAM2
Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
YHR007C 0.81
ERG11
Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family
YPL163C 0.81
SVS1
Cell wall and vacuolar protein, required for wild-type resistance to vanadate
YEL066W 0.80
HPA3
D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro
YLR249W 0.80
YEF3
Translational elongation factor 3, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex; contains two ABC cassettes; binds and hydrolyses ATP
YPL218W 0.79
SAR1
GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport
YBR183W 0.78
YPC1
Alkaline ceramidase that also has reverse (CoA-independent) ceramide synthase activity, catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance
YNL111C 0.78
CYB5
Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
YPR010C 0.75
RPA135
RNA polymerase I subunit A135
YGR234W 0.75
YHB1
Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses
YJR065C 0.75
ARP3
Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
YKR092C 0.74
SRP40
Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YNL327W 0.73
EGT2
Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner
YGL040C 0.72
HEM2
Delta-aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen, the second step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus
YLR420W 0.71
URA4
Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
YBR209W 0.70 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR209W is not an essential gene
YLL028W 0.70
TPO1
Polyamine transporter that recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane
YOR009W 0.70
TIR4
Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock
YOR013W 0.69
IRC11
Dubious opening reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012C; null mutant displays increased levels of spontaneous Rad52 foci
YEL052W 0.69
AFG1
Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain
YNL280C 0.68
ERG24
C-14 sterol reductase, acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions
YDL078C 0.68
MDH3
Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle
YCR028C-A 0.68
RIM1
Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication
YDR534C 0.67
FIT1
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YMR246W 0.67
FAA4
Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipids
YDR492W 0.66
IZH1
Membrane protein involved in zinc metabolism, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc
YCR012W 0.66
PGK1
3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
YPR119W 0.65
CLB2
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YML085C 0.65
TUB1
Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules
YDR491C 0.65 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YAL019W-A 0.65 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL052C 0.64
ASK1
Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases
YFR055W 0.64
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YHR137W 0.64
ARO9
Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism
YDR535C 0.64 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene.
YER130C 0.64 Hypothetical protein
YGL001C 0.63
ERG26
C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis
YBR158W 0.62
AMN1
Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YOR063W 0.62
RPL3
Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus
YDR023W 0.62
SES1
Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
YJR104C 0.62
SOD1
Cytosolic superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans
YDR094W 0.61 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
YHR050W-A 0.61 Protein of unknown function; identified by expression profiling and mass spectrometry
YBL098W 0.61
BNA4
Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease
YHL028W 0.61
WSC4
ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3
YLR355C 0.60
ILV5
Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA and found in mitochondrial nucleoids
YNL231C 0.59
PDR16
Phosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p, localizes to lipid particles and microsomes, controls levels of various lipids, may regulate lipid synthesis, homologous to Pdr17p
YER094C 0.58
PUP3
Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
YJL218W 0.58 Putative protein of unknown function, similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene
YKL097C 0.57 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YPR016C 0.56
TIF6
Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits
YMR318C 0.55
ADH6
NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance
YKR075C 0.55 Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YOL012C 0.55
HTZ1
Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
YNL315C 0.54
ATP11
Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase
YPL274W 0.54
SAM3
High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p
YDR099W 0.53
BMH2
14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
YCL018W 0.53
LEU2
Beta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis pathway
YJL079C 0.52
PRY1
Protein of unknown function, has similarity to Pry2p and Pry3p and to the plant PR-1 class of pathogen related proteins
YGR240C 0.52
PFK1
Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
YNL289W 0.52
PCL1
Pho85 cyclin of the Pcl1,2-like subfamily, involved in entry into the mitotic cell cycle and regulation of morphogenesis, localizes to sites of polarized cell growth
YKR093W 0.51
PTR2
Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
YOR008C-A 0.50 Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres
YER048W-A 0.50
ISD11
Protein required for mitochondrial iron-sulfur cluster biosynthesis
YOL039W 0.50
RPP2A
Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
YDR002W 0.50
YRB1
Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1
YPR014C 0.50 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene
YLR325C 0.49
RPL38
Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein
YIL052C 0.48
RPL34B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Ap and has similarity to rat L34 ribosomal protein
YEL068C 0.47 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YAL020C 0.47
ATS1
Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle
YGL039W 0.46 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YKL127W 0.46
PGM1
Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism
YBL044W 0.46 Putative protein of unknown function; YBL044W is not an essential protein
YDR454C 0.46
GUK1
Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins
YNL010W 0.46 Putative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation
YOL057W 0.46 Putative metalloprotease
YOR316C-A 0.45 Putative protein of unknown function; identified by fungal homology and RT-PCR
YGR259C 0.44 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W
YML126C 0.44
ERG13
3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
YPR170W-B 0.44 Putative protein of unknown function, conserved in fungi; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C
YPL015C 0.44
HST2
Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro
YBR121C 0.44
GRS1
Cytoplasmic and mitochondrial glycyl-tRNA synthase that ligates glycine to the cognate anticodon bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation
YBR023C 0.43
CHS3
Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
YHR094C 0.43
HXT1
Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YML123C 0.42
PHO84
High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p
YOL101C 0.42
IZH4
Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism
YEL067C 0.42 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKL128C 0.42
PMU1
Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
YKR038C 0.41
KAE1
Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex
YHR045W 0.41 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
YDR098C 0.41
GRX3
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YGL009C 0.41
LEU1
Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway
YNR001W-A 0.41 Dubious open reading frame unlikely to encode a functional protein; identified by homology
YNL065W 0.40
AQR1
Plasma membrane multidrug transporter of the major facilitator superfamily, confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids
YHR005C-A 0.40
MRS11
Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that mediates insertion of hydrophobic proteins at the inner membrane, has homology to Mrs5p, which is also involved in this process
YGR049W 0.40
SCM4
Potential regulatory effector of CDC4 function, suppresses a temperature-sensitive allele of CDC4, tripartite protein structure in which a charged region separates two uncharged domains, not essential for mitosis or meiosis
YPR088C 0.39
SRP54
Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain
YPR016W-A 0.39 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR088C 0.38
SLU7
RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
YFR056C 0.38 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YPR156C 0.37
TPO3
Polyamine transport protein specific for spermine; localizes to the plasma membrane; member of the major facilitator superfamily
YER117W 0.36
RPL23B
Protein component of the large (60S) ribosomal subunit, identical to Rpl23Ap and has similarity to E. coli L14 and rat L23 ribosomal proteins
YOR008C 0.36
SLG1
Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway involved in maintenance of cell wall integrity; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response
YAL029C 0.36
MYO4
One of two type V myosin motors (along with MYO2) involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p
YER048C 0.36
CAJ1
Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly
YGR108W 0.36
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YLR056W 0.35
ERG3
C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources
YPR139C 0.35
VPS66
Cytoplasmic protein of unknown function involved in vacuolar protein sorting.
YDL085C-A 0.34 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YKL068W-A 0.34 Putative protein of unknown function; identified by homology to Ashbya gossypii
YDR345C 0.34
HXT3
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YBR041W 0.34
FAT1
Fatty acid transporter and very long-chain fatty acyl-CoA synthetase, may form a complex with Faa1p or Faa4p that imports and activates exogenous fatty acids
YER043C 0.34
SAH1
S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
YJL115W 0.34
ASF1
Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition
YOR273C 0.33
TPO4
Polyamine transport protein, recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily
YML027W 0.33
YOX1
Homeodomain-containing transcriptional repressor, binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate
YLR312W-A 0.33
MRPL15
Mitochondrial ribosomal protein of the large subunit
YLR153C 0.33
ACS2
Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
YGR180C 0.32
RNR4
Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
YFR039C 0.32 Putative protein of unknown function; may be involved in response to high salt and changes in carbon source
YNL162W 0.32
RPL42A
Protein component of the large (60S) ribosomal subunit, identical to Rpl42Bp and has similarity to rat L44 ribosomal protein
YMR146C 0.32
TIF34
Subunit of the core complex of translation initiation factor 3(eIF3), which is essential for translation
YOL005C 0.32
RPB11
RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit
YJR020W 0.31 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL096W 0.31
CWP1
Cell wall mannoprotein, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; involved in cell wall organization
YLR113W 0.31
HOG1
Mitogen-activated protein kinase involved in osmoregulation via three independent osmosensors; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p
YGR052W 0.31
FMP48
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
YER141W 0.30
COX15
Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
YJL025W 0.30
RRN7
Protein involved in the transcription of 35S rRNA genes by RNA polymerase I; component of the core factor (CF) complex also composed of Rrn11p, Rrn6p and TATA-binding protein
YNL070W 0.30
TOM7
Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
YDL055C 0.30
PSA1
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YER095W 0.29
RAD51
Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein
YGR260W 0.29
TNA1
High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)
YOL152W 0.28
FRE7
Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels
YGL202W 0.28
ARO8
Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis
YOL040C 0.27
RPS15
Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S19 and rat S15 ribosomal proteins
YPL249C-A 0.27
RPL36B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Ap and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA
YKR013W 0.27
PRY2
Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins
YHR010W 0.27
RPL27A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Bp and has similarity to rat L27 ribosomal protein

Network of associatons between targets according to the STRING database.

First level regulatory network of HAP1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.9 GO:0000752 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.7 2.0 GO:0044209 AMP salvage(GO:0044209)
0.5 3.7 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.5 2.0 GO:1904357 negative regulation of telomere maintenance via telomerase(GO:0032211) negative regulation of telomere maintenance via telomere lengthening(GO:1904357)
0.5 1.9 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.5 1.4 GO:0019673 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
0.4 1.6 GO:0046490 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490)
0.4 0.4 GO:0032973 amino acid export(GO:0032973)
0.4 1.6 GO:0015848 spermidine transport(GO:0015848)
0.4 2.7 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.3 0.9 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.3 7.4 GO:0016129 ergosterol biosynthetic process(GO:0006696) phytosteroid biosynthetic process(GO:0016129) cellular alcohol biosynthetic process(GO:0044108) cellular lipid biosynthetic process(GO:0097384)
0.3 0.9 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.3 0.8 GO:0046466 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.3 0.5 GO:0000296 spermine transport(GO:0000296)
0.2 4.3 GO:0006407 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
0.2 1.6 GO:0019660 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
0.2 0.9 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
0.2 0.7 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.2 1.1 GO:0055069 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.2 0.6 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.2 0.6 GO:0097052 L-kynurenine metabolic process(GO:0097052) L-kynurenine catabolic process(GO:0097053)
0.2 0.6 GO:0072353 cellular age-dependent response to reactive oxygen species(GO:0072353)
0.2 0.7 GO:0009099 valine biosynthetic process(GO:0009099)
0.2 1.4 GO:0016126 steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126)
0.2 0.8 GO:0018344 protein geranylgeranylation(GO:0018344)
0.2 1.0 GO:0044205 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.2 0.3 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.2 0.8 GO:0009098 leucine biosynthetic process(GO:0009098)
0.2 0.8 GO:0048209 regulation of COPII vesicle coating(GO:0003400) regulation of vesicle targeting, to, from or within Golgi(GO:0048209) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.2 1.3 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.2 0.9 GO:0008299 isoprenoid metabolic process(GO:0006720) isoprenoid biosynthetic process(GO:0008299)
0.2 0.6 GO:0034627 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.2 0.5 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.1 0.4 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.1 0.6 GO:0042256 mature ribosome assembly(GO:0042256)
0.1 1.2 GO:0006829 zinc II ion transport(GO:0006829)
0.1 3.5 GO:0006885 regulation of pH(GO:0006885)
0.1 0.5 GO:0006222 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.1 0.9 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
0.1 0.5 GO:0014070 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
0.1 1.2 GO:0009395 phospholipid catabolic process(GO:0009395)
0.1 0.6 GO:0060277 obsolete negative regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0060277)
0.1 0.5 GO:0006011 UDP-glucose metabolic process(GO:0006011) glucose 1-phosphate metabolic process(GO:0019255)
0.1 0.5 GO:0006108 malate metabolic process(GO:0006108)
0.1 0.6 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.1 0.9 GO:0008615 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.1 0.3 GO:0002188 translation reinitiation(GO:0002188)
0.1 3.0 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 0.7 GO:0042938 dipeptide transport(GO:0042938)
0.1 0.3 GO:0006784 heme a biosynthetic process(GO:0006784) heme a metabolic process(GO:0046160)
0.1 0.9 GO:0031506 cell wall mannoprotein biosynthetic process(GO:0000032) mannoprotein metabolic process(GO:0006056) mannoprotein biosynthetic process(GO:0006057) cell wall glycoprotein biosynthetic process(GO:0031506)
0.1 0.8 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1 1.3 GO:0000147 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.1 0.3 GO:0042148 strand invasion(GO:0042148)
0.1 0.8 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.1 1.1 GO:0007120 axial cellular bud site selection(GO:0007120)
0.1 0.6 GO:0000743 nuclear migration involved in conjugation with cellular fusion(GO:0000743)
0.1 1.4 GO:0006415 translational termination(GO:0006415)
0.1 2.3 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.1 0.2 GO:0006567 threonine catabolic process(GO:0006567)
0.1 0.6 GO:0006828 manganese ion transport(GO:0006828)
0.1 0.5 GO:0006083 acetate metabolic process(GO:0006083)
0.1 0.5 GO:0046037 GMP metabolic process(GO:0046037)
0.1 0.3 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
0.1 0.4 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.1 1.4 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.1 0.3 GO:0007535 donor selection(GO:0007535)
0.1 0.3 GO:1901985 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.1 0.3 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
0.1 0.2 GO:0018216 peptidyl-arginine modification(GO:0018195) peptidyl-arginine methylation(GO:0018216)
0.1 0.2 GO:0009262 deoxyribonucleotide metabolic process(GO:0009262) deoxyribonucleotide biosynthetic process(GO:0009263)
0.1 0.8 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.1 0.4 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.1 2.1 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.1 0.4 GO:0006835 dicarboxylic acid transport(GO:0006835)
0.1 0.1 GO:0033673 negative regulation of kinase activity(GO:0033673)
0.1 0.2 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.1 0.1 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.1 0.8 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 0.2 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.1 1.3 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.1 0.5 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.1 0.2 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.1 0.3 GO:0042407 cristae formation(GO:0042407)
0.1 0.2 GO:0006901 vesicle coating(GO:0006901)
0.1 0.3 GO:0090158 regulation of phosphatidylinositol dephosphorylation(GO:0060304) endoplasmic reticulum membrane organization(GO:0090158)
0.0 0.4 GO:0071966 fungal-type cell wall chitin biosynthetic process(GO:0034221) fungal-type cell wall polysaccharide biosynthetic process(GO:0051278) fungal-type cell wall polysaccharide metabolic process(GO:0071966)
0.0 0.7 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0 0.2 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.0 0.1 GO:0008204 ergosterol metabolic process(GO:0008204) phytosteroid metabolic process(GO:0016128)
0.0 0.4 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.2 GO:0046931 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.0 0.6 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.0 0.3 GO:0071709 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.0 0.2 GO:0006596 polyamine biosynthetic process(GO:0006596)
0.0 0.1 GO:0090110 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.1 GO:0070096 mitochondrial outer membrane translocase complex assembly(GO:0070096)
0.0 0.4 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615) proton-transporting ATP synthase complex assembly(GO:0043461)
0.0 0.4 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.0 1.2 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.0 0.2 GO:0035437 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.0 0.4 GO:0048309 endoplasmic reticulum inheritance(GO:0048309)
0.0 0.3 GO:0015677 copper ion import(GO:0015677)
0.0 0.5 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.1 GO:0009097 isoleucine biosynthetic process(GO:0009097)
0.0 0.3 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.0 0.1 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.0 0.1 GO:0019405 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.0 4.8 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.1 GO:1905038 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.0 0.1 GO:0015886 heme transport(GO:0015886)
0.0 0.7 GO:0002097 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.0 0.3 GO:0046020 negative regulation of transcription by pheromones(GO:0045996) negative regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046020)
0.0 0.2 GO:0005985 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.0 0.2 GO:0000376 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.0 0.1 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.0 0.6 GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay(GO:0070481)
0.0 0.1 GO:0009371 positive regulation of transcription from RNA polymerase II promoter by pheromones(GO:0007329) positive regulation of transcription by pheromones(GO:0009371)
0.0 0.5 GO:1901264 carbohydrate derivative transport(GO:1901264)
0.0 0.3 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.0 0.4 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.0 0.1 GO:0001933 negative regulation of protein phosphorylation(GO:0001933)
0.0 0.1 GO:0009396 folic acid-containing compound metabolic process(GO:0006760) folic acid-containing compound biosynthetic process(GO:0009396) pteridine-containing compound metabolic process(GO:0042558) pteridine-containing compound biosynthetic process(GO:0042559)
0.0 0.1 GO:0090337 regulation of actin filament bundle assembly(GO:0032231) positive regulation of actin filament bundle assembly(GO:0032233) regulation of formin-nucleated actin cable assembly(GO:0090337) positive regulation of formin-nucleated actin cable assembly(GO:0090338)
0.0 0.1 GO:0045836 positive regulation of meiotic nuclear division(GO:0045836) positive regulation of meiotic cell cycle(GO:0051446)
0.0 0.2 GO:0043171 peptide catabolic process(GO:0043171) positive regulation of protein catabolic process(GO:0045732)
0.0 0.2 GO:0043687 C-terminal protein amino acid modification(GO:0018410) post-translational protein modification(GO:0043687)
0.0 0.6 GO:0045047 protein targeting to ER(GO:0045047)
0.0 0.1 GO:0036170 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
0.0 0.2 GO:0006450 regulation of translational fidelity(GO:0006450)
0.0 0.4 GO:0032508 DNA duplex unwinding(GO:0032508)
0.0 0.2 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.0 1.3 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.0 GO:0090662 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.0 0.1 GO:0046348 aminoglycan catabolic process(GO:0006026) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.0 0.1 GO:0031125 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000467) rRNA 3'-end processing(GO:0031125) U5 snRNA 3'-end processing(GO:0034476) nuclear retention of pre-mRNA at the site of transcription(GO:0071033)
0.0 0.1 GO:0006448 regulation of translational elongation(GO:0006448)
0.0 0.1 GO:0042401 amine biosynthetic process(GO:0009309) cellular biogenic amine biosynthetic process(GO:0042401)
0.0 0.3 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.3 GO:0030472 mitotic spindle organization in nucleus(GO:0030472)
0.0 0.1 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.2 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.0 0.1 GO:0006272 leading strand elongation(GO:0006272)
0.0 0.2 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 0.2 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.1 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity(GO:0051090)
0.0 0.2 GO:0006865 amino acid transport(GO:0006865)
0.0 0.0 GO:0015883 FAD transport(GO:0015883)
0.0 1.2 GO:0051169 nucleocytoplasmic transport(GO:0006913) nuclear transport(GO:0051169)
0.0 0.1 GO:0045860 positive regulation of protein kinase activity(GO:0045860)
0.0 0.0 GO:0007030 Golgi organization(GO:0007030)
0.0 0.0 GO:0033014 porphyrin-containing compound biosynthetic process(GO:0006779) heme biosynthetic process(GO:0006783) tetrapyrrole biosynthetic process(GO:0033014)
0.0 1.8 GO:0006364 rRNA processing(GO:0006364)
0.0 0.0 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.0 0.1 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682) glucose 6-phosphate metabolic process(GO:0051156)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.7 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.6 1.7 GO:0030428 cell septum(GO:0030428)
0.2 0.6 GO:0005827 polar microtubule(GO:0005827) tubulin complex(GO:0045298)
0.1 1.1 GO:0005688 U6 snRNP(GO:0005688)
0.1 0.5 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1 4.8 GO:0005811 lipid particle(GO:0005811)
0.1 0.4 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1 5.8 GO:0031225 anchored component of membrane(GO:0031225)
0.1 0.9 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 0.9 GO:0033101 cellular bud membrane(GO:0033101)
0.1 0.8 GO:0072686 mitotic spindle(GO:0072686)
0.1 1.1 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.1 0.7 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 0.6 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.1 0.3 GO:0044284 mitochondrial crista junction(GO:0044284)
0.1 0.3 GO:0070860 RNA polymerase I core factor complex(GO:0070860)
0.1 0.9 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 1.7 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 0.3 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.1 5.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 0.4 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.1 0.9 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 0.1 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1 3.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.4 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 0.2 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.1 0.7 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 0.4 GO:0016459 myosin complex(GO:0016459)
0.1 1.4 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 0.1 GO:0008275 gamma-tubulin small complex, spindle pole body(GO:0000928) gamma-tubulin complex(GO:0000930) gamma-tubulin small complex(GO:0008275)
0.0 1.1 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 0.3 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852) multi-eIF complex(GO:0043614)
0.0 0.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.8 GO:0016586 RSC complex(GO:0016586)
0.0 0.2 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.0 0.1 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.0 0.1 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 0.5 GO:0000786 nucleosome(GO:0000786)
0.0 0.1 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.2 GO:0031389 Rad17 RFC-like complex(GO:0031389) Elg1 RFC-like complex(GO:0031391)
0.0 0.2 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.1 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.5 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 1.0 GO:0005576 extracellular region(GO:0005576)
0.0 0.1 GO:0031501 alpha-1,6-mannosyltransferase complex(GO:0000136) mannosyltransferase complex(GO:0031501)
0.0 0.1 GO:0000938 GARP complex(GO:0000938)
0.0 0.2 GO:0005724 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.0 0.1 GO:0000817 COMA complex(GO:0000817)
0.0 1.4 GO:0044445 cytosolic part(GO:0044445)
0.0 0.8 GO:0005844 polysome(GO:0005844)
0.0 0.1 GO:0042555 MCM complex(GO:0042555)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.1 GO:0033180 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 1.0 GO:0030479 actin cortical patch(GO:0030479) endocytic patch(GO:0061645)
0.0 0.2 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.2 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 0.1 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.1 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.0 5.2 GO:0005886 plasma membrane(GO:0005886)
0.0 0.7 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.1 GO:0022624 proteasome regulatory particle(GO:0005838) proteasome accessory complex(GO:0022624)
0.0 0.1 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.0 0.6 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.1 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.1 GO:0034399 nuclear periphery(GO:0034399)
0.0 0.0 GO:0070209 ASTRA complex(GO:0070209)
0.0 0.1 GO:0034967 Set3 complex(GO:0034967)
0.0 1.7 GO:0005730 nucleolus(GO:0005730)
0.0 2.9 GO:0005783 endoplasmic reticulum(GO:0005783)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.7 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.7 2.0 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.6 3.9 GO:0016408 C-acyltransferase activity(GO:0016408)
0.5 2.2 GO:0019206 nucleoside kinase activity(GO:0019206)
0.4 1.7 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.4 2.4 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.4 1.6 GO:0015606 spermidine transmembrane transporter activity(GO:0015606)
0.4 2.6 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.3 0.3 GO:0015645 fatty acid ligase activity(GO:0015645)
0.3 1.2 GO:0004622 lysophospholipase activity(GO:0004622)
0.3 1.8 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.3 3.6 GO:0005199 structural constituent of cell wall(GO:0005199)
0.3 0.9 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.3 1.1 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.3 0.5 GO:0008106 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.3 2.1 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.3 0.5 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
0.2 1.0 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.2 2.4 GO:0005216 ion channel activity(GO:0005216)
0.2 0.9 GO:0042973 glucan endo-1,3-beta-D-glucosidase activity(GO:0042973)
0.2 2.0 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.2 0.7 GO:0051219 phosphoprotein binding(GO:0051219)
0.2 0.6 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.2 1.2 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.2 0.8 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.2 0.9 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.2 0.5 GO:0016504 peptidase activator activity(GO:0016504)
0.2 1.0 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.2 0.2 GO:0015248 sterol transporter activity(GO:0015248)
0.2 0.7 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.2 0.8 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)
0.2 0.9 GO:0004659 prenyltransferase activity(GO:0004659)
0.2 1.2 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.4 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.1 0.4 GO:0004100 chitin synthase activity(GO:0004100)
0.1 0.5 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
0.1 0.5 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 0.5 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.1 0.6 GO:0008525 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.1 0.5 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.1 0.3 GO:0004525 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.1 0.3 GO:0016208 AMP binding(GO:0016208) acid-ammonia (or amide) ligase activity(GO:0016880)
0.1 0.6 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.1 1.3 GO:0030276 clathrin binding(GO:0030276)
0.1 0.4 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.1 0.5 GO:0008443 phosphofructokinase activity(GO:0008443)
0.1 0.3 GO:0001187 transcription factor activity, RNA polymerase I CORE element sequence-specific binding(GO:0001169) transcription factor activity, RNA polymerase I CORE element binding transcription factor recruiting(GO:0001187)
0.1 0.3 GO:0070568 guanylyltransferase activity(GO:0070568)
0.1 0.3 GO:0000150 recombinase activity(GO:0000150)
0.1 0.8 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 1.0 GO:0005496 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.1 0.4 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 0.2 GO:0043178 alcohol binding(GO:0043178)
0.1 0.5 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.1 0.7 GO:0010181 FMN binding(GO:0010181)
0.1 0.4 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 0.5 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.1 0.4 GO:0070403 NAD+ binding(GO:0070403)
0.1 0.3 GO:0001055 RNA polymerase II activity(GO:0001055)
0.1 0.3 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.1 0.4 GO:0008312 7S RNA binding(GO:0008312)
0.1 0.3 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.1 0.3 GO:0016841 ammonia-lyase activity(GO:0016841)
0.1 0.2 GO:0008097 5S rRNA binding(GO:0008097)
0.1 0.4 GO:0000146 microfilament motor activity(GO:0000146)
0.1 0.2 GO:0004575 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
0.1 0.2 GO:0016273 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.1 0.5 GO:0019201 nucleotide kinase activity(GO:0019201)
0.1 0.7 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 0.3 GO:0004707 MAP kinase activity(GO:0004707)
0.1 0.9 GO:0001054 RNA polymerase I activity(GO:0001054)
0.1 2.1 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 0.1 GO:0019210 kinase inhibitor activity(GO:0019210)
0.1 0.2 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.1 0.8 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 0.3 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0 0.8 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.2 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 1.2 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 9.1 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.6 GO:0015266 protein channel activity(GO:0015266)
0.0 0.2 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.0 0.1 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.0 1.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.3 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.0 0.9 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 0.2 GO:0001129 RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly(GO:0001128) RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129)
0.0 0.2 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)
0.0 0.3 GO:0000293 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.0 0.9 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 0.1 GO:0015216 purine nucleotide transmembrane transporter activity(GO:0015216)
0.0 0.1 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.1 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.1 GO:0005347 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
0.0 0.2 GO:0008171 O-methyltransferase activity(GO:0008171)
0.0 1.8 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616)
0.0 0.2 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.3 GO:0051184 cofactor transporter activity(GO:0051184)
0.0 0.5 GO:0046943 carboxylic acid transmembrane transporter activity(GO:0046943)
0.0 0.3 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.4 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 0.4 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.1 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.1 GO:0015085 calcium ion transmembrane transporter activity(GO:0015085)
0.0 0.3 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.6 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.4 GO:0008483 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.0 0.1 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.5 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.1 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.1 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.5 GO:0051087 chaperone binding(GO:0051087)
0.0 0.1 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.2 GO:0019239 deaminase activity(GO:0019239)
0.0 0.9 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.1 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.1 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0 0.1 GO:0016882 cyclo-ligase activity(GO:0016882)
0.0 0.5 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.2 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.0 0.2 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.1 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.0 0.1 GO:0016866 intramolecular transferase activity(GO:0016866)
0.0 0.4 GO:0016853 isomerase activity(GO:0016853)
0.0 0.1 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.0 0.1 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.4 GO:0008135 translation factor activity, RNA binding(GO:0008135)
0.0 0.1 GO:0008235 metalloexopeptidase activity(GO:0008235)
0.0 0.4 GO:0003779 actin binding(GO:0003779)
0.0 0.1 GO:0005048 signal sequence binding(GO:0005048)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 0.7 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 0.1 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 0.3 PID P73PATHWAY p73 transcription factor network
0.0 0.1 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.0 0.2 PID ATR PATHWAY ATR signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.2 0.9 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.2 4.4 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.2 0.5 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 1.1 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 0.6 REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION Genes involved in Platelet activation, signaling and aggregation
0.1 0.3 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 0.4 REACTOME TRANSLATION Genes involved in Translation
0.1 0.1 REACTOME METABOLISM OF MRNA Genes involved in Metabolism of mRNA
0.0 0.2 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 0.1 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.1 REACTOME GPCR LIGAND BINDING Genes involved in GPCR ligand binding
0.0 0.1 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.0 0.1 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.0 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.0 0.1 REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism