Results for HAP1
Z-value: 1.05
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Transcription factors associated with HAP1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
HAP1
|
S000004246 | Transcription factor involved in response to levels of heme and oxygen |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YLR154W-B Show fit | 5.14 |
Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand |
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| YLR154W-A Show fit | 5.11 |
Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand |
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| YKL096W-A Show fit | 3.32 |
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored |
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| YLR110C Show fit | 2.98 |
Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor |
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| YER131W Show fit | 2.78 |
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein |
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| YLR154C Show fit | 2.66 |
Ribonuclease H2 subunit, required for RNase H2 activity |
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| YDR033W Show fit | 2.30 |
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p |
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| YPL028W Show fit | 2.25 |
Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis |
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| YJR105W Show fit | 2.13 |
Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle |
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| YGR280C Show fit | 1.97 |
Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain |
Network of associatons between targets according to the STRING database.
First level regulatory network of HAP1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 7.4 | GO:0016129 | ergosterol biosynthetic process(GO:0006696) phytosteroid biosynthetic process(GO:0016129) cellular alcohol biosynthetic process(GO:0044108) cellular lipid biosynthetic process(GO:0097384) |
| 0.0 | 4.8 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.2 | 4.3 | GO:0006407 | rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029) |
| 0.5 | 3.7 | GO:0006782 | protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501) |
| 0.1 | 3.5 | GO:0006885 | regulation of pH(GO:0006885) |
| 0.1 | 3.0 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 0.7 | 2.9 | GO:0000752 | agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742) |
| 0.4 | 2.7 | GO:0043137 | DNA replication, removal of RNA primer(GO:0043137) |
| 0.1 | 2.3 | GO:0003333 | amino acid transmembrane transport(GO:0003333) |
| 0.1 | 2.1 | GO:0006418 | tRNA aminoacylation for protein translation(GO:0006418) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.8 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 5.6 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 5.2 | GO:0005886 | plasma membrane(GO:0005886) |
| 0.1 | 4.8 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 3.4 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 2.9 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.9 | 2.7 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.6 | 1.7 | GO:0030428 | cell septum(GO:0030428) |
| 0.1 | 1.7 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 1.7 | GO:0005730 | nucleolus(GO:0005730) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.6 | 3.9 | GO:0016408 | C-acyltransferase activity(GO:0016408) |
| 0.3 | 3.6 | GO:0005199 | structural constituent of cell wall(GO:0005199) |
| 0.7 | 2.7 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 0.4 | 2.6 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 0.4 | 2.4 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
| 0.2 | 2.4 | GO:0005216 | ion channel activity(GO:0005216) |
| 0.5 | 2.2 | GO:0019206 | nucleoside kinase activity(GO:0019206) |
| 0.3 | 2.1 | GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861) |
| 0.1 | 2.1 | GO:0004812 | aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.1 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 0.7 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 0.3 | PID P73PATHWAY | p73 transcription factor network |
| 0.0 | 0.2 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 0.1 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 0.1 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.4 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 0.4 | 1.1 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 1.1 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.2 | 0.9 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 0.6 | REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION | Genes involved in Platelet activation, signaling and aggregation |
| 0.2 | 0.5 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.1 | 0.4 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.1 | 0.3 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.0 | 0.2 | REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
| 0.1 | 0.1 | REACTOME METABOLISM OF MRNA | Genes involved in Metabolism of mRNA |