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Results for GZF3

Z-value: 0.66

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Transcription factors associated with GZF3

Gene Symbol Gene ID Gene Info
GZF3
S000003646 GATA zinc finger protein

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GZF3YJL110C0.203.4e-01Click!

Activity profile of GZF3 motif

Sorted Z-values of GZF3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YDL210W 6.90
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YER065C 6.47
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YKR034W 4.88
DAL80
Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Deh1p
YAR050W 4.60
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YIR027C 3.84
DAL1
Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression
YAR047C 3.70 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR296W 3.52 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR343C 3.38
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YLR142W 3.30
PUT1
Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
YNL195C 3.25 Putative protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YIL162W 3.22
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YMR107W 3.06
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YEL059W 3.00 Dubious open reading frame unlikely to encode a functional protein
YLR295C 2.91
ATP14
Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YHR212C 2.87 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YAL062W 2.85
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YBL049W 2.81
MOH1
Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase
YNR002C 2.64
ATO2
Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p
YHR212W-A 2.63 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YOR348C 2.57
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YGR144W 2.46
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YNL144C 2.33 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YER014C-A 2.02
BUD25
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YKR015C 1.97 Putative protein of unknown function
YPR026W 1.92
ATH1
Acid trehalase required for utilization of extracellular trehalose
YLL056C 1.90 Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene
YLL055W 1.87
YCT1
High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
YER066W 1.87 Putative protein of unknown function; YER066W is not an essential gene
YMR081C 1.86
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YNL142W 1.84
MEP2
Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YPR196W 1.71 Putative maltose activator
YAR053W 1.68 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR346W 1.66
REV1
Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YLR297W 1.66 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YLR297W is not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation
YGR213C 1.64
RTA1
Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions
YIL146C 1.61
ECM37
Non-essential protein of unknown function
YDL138W 1.61
RGT2
Plasma membrane glucose receptor, highly similar to Snf3p; both Rgt2p and Snf3p serve as transmembrane glucose sensors generating an intracellular signal that induces expression of glucose transporter (HXT) genes
YBR292C 1.59 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
YLR356W 1.56 Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YOR178C 1.54
GAC1
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YJR152W 1.54
DAL5
Allantoin permease; ureidosuccinate permease; expression is constitutive but sensitive to nitrogen catabolite repression
YFR053C 1.51
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YBL048W 1.51 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YLR346C 1.50 Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene
YDL244W 1.50
THI13
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YIR029W 1.50
DAL2
Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YOR345C 1.50 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YFR029W 1.45
PTR3
Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
YJL213W 1.45 Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p
YDR034C 1.43
LYS14
Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
YKR016W 1.43
AIM28
Protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss and severe growth defect in minimal glycerol media
YBR117C 1.41
TKL2
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YHR139C 1.36
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YDR540C 1.35
IRC4
Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YDL215C 1.32
GDH2
NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels
YAR060C 1.32 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR077C 1.27
SLM4
Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
YMR311C 1.22
GLC8
Regulatory subunit of protein phosphatase 1 (Glc7p), involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2
YJL067W 1.20 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL103C 1.19
LAP4
Vacuolar aminopeptidase, often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway
YOL047C 1.16 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YNL125C 1.15
ESBP6
Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
YER076W-A 1.15 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER076C
YER150W 1.13
SPI1
GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YER084W 1.12 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR379C 1.10 Hypothetical protein
YER076C 1.10 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization
YOR066W 1.09
MSA1
Activator of G1-specific transcription factors, MBF and SBF, that regulates both the timing of G1-specific gene transcription, and cell cycle initiation; potential Cdc28p substrate
YMR118C 1.07 Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene
YOR382W 1.07
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YKL217W 1.07
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YDL170W 1.04
UGA3
Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus
YGR087C 1.03
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YIR028W 1.01
DAL4
Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YER116C 1.00
SLX8
Subunit of the Slx5-Slx8 substrate-specific ubiquitin ligase complex; stimulated by prior attachment of SUMO to the substrate
YNL143C 0.99 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR231C 0.99
COX20
Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
YJR008W 0.99 Putative protein of unknown function; expression repressed by inosine and choline in an Opi1p-dependent manner; expression induced by mild heat-stress on a non-fermentable carbon source.
YNR034W 0.98
SOL1
Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol2p, Sol3p, and Sol4p
YDR542W 0.98
PAU10
Hypothetical protein
YHL046W-A 0.98 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBL015W 0.96
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YGR043C 0.95
NQM1
Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity
YJL116C 0.94
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YLL039C 0.93
UBI4
Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats
YEL039C 0.93
CYC7
Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YMR170C 0.92
ALD2
Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p
YOR152C 0.90 Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YKR032W 0.90 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBL094C 0.90 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W
YOL128C 0.90
YGK3
Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation
YHL047C 0.89
ARN2
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C
YGR201C 0.89 Putative protein of unknown function
YBL039W-B 0.89 Putative protein of unknown function
YEL024W 0.88
RIP1
Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration
YHR199C 0.88
AIM46
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YKR097W 0.88
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YML042W 0.88
CAT2
Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
YNL176C 0.88 Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p
YCR068W 0.87
ATG15
Lipase, required for intravacuolar lysis of autophagosomes; located in the endoplasmic reticulum membrane and targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway
YOL163W 0.86 Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family
YPL089C 0.86
RLM1
MADS-box transcription factor, component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p
YLR332W 0.84
MID2
O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
YOR380W 0.84
RDR1
Transcriptional repressor involved in the control of multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins
YJL045W 0.83 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YCL066W 0.83
HMLALPHA1
Silenced copy of ALPHA1 at HML, encoding a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression
YKL102C 0.82 Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
YPL236C 0.82 Putative protein kinase that exhibits Akr1p-dependent palmitoylation
YBR056W-A 0.82 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR056C-B
YAL063C 0.82
FLO9
Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
YLL053C 0.81 Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YLR331C 0.81
JIP3
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
YCL025C 0.80
AGP1
Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)
YCR021C 0.80
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YGL096W 0.80
TOS8
Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p
YEL060C 0.80
PRB1
Vacuolar proteinase B (yscB), a serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation
YDR262W 0.79 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment
YNL101W 0.78
AVT4
Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YFR017C 0.78 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene
YOR003W 0.77
YSP3
Putative precursor to the subtilisin-like protease III
YCL067C 0.77
HMLALPHA2
Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expression
YJR096W 0.77 Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YBL078C 0.76
ATG8
Conserved protein that is a component of autophagosomes and Cvt vesicles; undergoes C-terminal conjugation to phosphatidylethanolamine (PE), Atg8p-PE is anchored to membranes and may mediate membrane fusion during autophagosome formation
YCL048W 0.76
SPS22
Protein of unknown function, redundant with Sps2p for the organization of the beta-glucan layer of the spore wall
YLR299W 0.76
ECM38
Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation
YNL018C 0.75 Putative protein of unknown function
YHR126C 0.75 Putative protein of unknown function; transcription dependent upon Azf1p
YOR173W 0.75
DCS2
Non-essential, stress induced regulatory protein containing a HIT (histidine triad) motif; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway, similar to Dcs1p.
YKR049C 0.75
FMP46
Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YHR202W 0.74 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization
YKR039W 0.74
GAP1
General amino acid permease; localization to the plasma membrane is regulated by nitrogen source
YGR129W 0.74
SYF2
Component of the spliceosome complex involved in pre-mRNA splicing; involved in regulation of cell cycle progression
YEL059C-A 0.73
SOM1
Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates
YBR293W 0.73
VBA2
Permease of basic amino acids in the vacuolar membrane
YFL051C 0.73 Putative protein of unknown function; YFL051C is not an essential gene
YIL099W 0.73
SGA1
Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
YDR342C 0.72
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YOL052C-A 0.72
DDR2
Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses
YDR541C 0.72 Putative dihydrokaempferol 4-reductase
YHR189W 0.71
PTH1
One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for cell growth and for mitochondrial respiration
YLL052C 0.71
AQY2
Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YAR070C 0.71 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAR069C 0.70 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJR078W 0.70
BNA2
Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p
YFL063W 0.70 Dubious open reading frame, based on available experimental and comparative sequence data
YGR244C 0.69
LSC2
Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate
YDR092W 0.68
UBC13
Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus
YHL016C 0.68
DUR3
Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
YLR164W 0.68 Mitochondrial inner membrane of unknown function; similar to Tim18p and Sdh4p; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YJL103C 0.67
GSM1
Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis
YPR001W 0.66
CIT3
Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate
YLL018C-A 0.66
COX19
Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase
YPL088W 0.66 Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
YHR211W 0.65
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YDL182W 0.65
LYS20
Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys21p
YPL234C 0.65
TFP3
Vacuolar ATPase V0 domain subunit c', involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen
YGR281W 0.65
YOR1
Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin
YDL245C 0.65
HXT15
Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose
YDR059C 0.64
UBC5
Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins, central component of the cellular stress response; expression is heat inducible
YPR160W 0.63
GPH1
Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
YKR102W 0.62
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YKR009C 0.61
FOX2
Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
YHR096C 0.61
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YKL163W 0.61
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YAR068W 0.61 Fungal-specific protein of unknown function; induced in respiratory-deficient cells
YDR232W 0.60
HEM1
5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
YPL135W 0.60
ISU1
Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable
YJR128W 0.59 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2
YOR387C 0.59 Putative protein of unknown function; regulated by the metal-responsive Aft1p transcription factor; highly inducible in zinc-depleted conditions; localizes to the soluble fraction
YBR296C 0.59
PHO89
Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
YMR068W 0.59
AVO2
Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
YAR023C 0.59 Putative integral membrane protein, member of DUP240 gene family
YFL021W 0.58
GAT1
Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p
YDR528W 0.58
HLR1
Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A
YLR259C 0.58
HSP60
Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated
YDL139C 0.57
SCM3
Nonhistone component of centromeric chromatin that binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; contains nuclear export signal (NES); required for G2/M progression and localization of Cse4p
YAL067C 0.57
SEO1
Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
YCL054W 0.56
SPB1
AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants
YGR088W 0.56
CTT1
Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YER188C-A 0.56 Putative protein of unknown function
YBR291C 0.55
CTP1
Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family
YOR376W 0.55 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.
YFL064C 0.55 Putative protein of unknown function
YDL169C 0.54
UGX2
Protein of unknown function, transcript accumulates in response to any combination of stress conditions
YEL072W 0.54
RMD6
Protein required for sporulation
YDR379C-A 0.54 Hypothetical protein identified by homology. See FEBS Letters [2000] 487:31-36.
YJR150C 0.54
DAN1
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YMR040W 0.53
YET2
Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
YKL065W-A 0.53 Putative protein of unknown function
YDR277C 0.53
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YOR338W 0.53 Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen
YDL238C 0.53
GUD1
Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures
YPL054W 0.52
LEE1
Zinc-finger protein of unknown function
YNR011C 0.52
PRP2
RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing
YKL192C 0.52
ACP1
Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p
YNL117W 0.51
MLS1
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YNL036W 0.51
NCE103
Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway
YBR101C 0.50
FES1
Hsp70 (Ssa1p) nucleotide exchange factor, cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum
YGR197C 0.50
SNG1
Protein involved in nitrosoguanidine (MNNG) resistance; expression is regulated by transcription factors involved in multidrug resistance
YNL104C 0.50
LEU4
Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway

Network of associatons between targets according to the STRING database.

First level regulatory network of GZF3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 7.1 GO:0015847 putrescine transport(GO:0015847)
1.7 5.1 GO:0090295 nitrogen catabolite repression of transcription(GO:0090295)
1.1 3.3 GO:0010133 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
1.1 6.4 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
1.0 4.1 GO:0015804 neutral amino acid transport(GO:0015804)
0.9 7.2 GO:0006097 glyoxylate cycle(GO:0006097)
0.9 6.2 GO:0000256 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256)
0.8 1.5 GO:0015755 fructose transport(GO:0015755)
0.7 2.0 GO:0009593 detection of chemical stimulus(GO:0009593) detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) detection of stimulus(GO:0051606)
0.7 2.0 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.6 1.9 GO:0005993 trehalose catabolic process(GO:0005993)
0.6 3.3 GO:0042407 cristae formation(GO:0042407)
0.5 1.5 GO:0006538 glutamate catabolic process(GO:0006538)
0.5 1.5 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.5 1.4 GO:2000284 positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.4 1.3 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
0.4 3.3 GO:0005987 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.4 1.2 GO:0045895 positive regulation of mating-type specific transcription, DNA-templated(GO:0045895)
0.4 1.5 GO:0043200 response to amino acid(GO:0043200)
0.4 1.1 GO:0045894 regulation of mating-type specific transcription from RNA polymerase II promoter(GO:0001196) negative regulation of mating-type specific transcription from RNA polymerase II promoter(GO:0001198) negative regulation of mating-type specific transcription, DNA-templated(GO:0045894)
0.3 1.0 GO:0009448 gamma-aminobutyric acid metabolic process(GO:0009448) gamma-aminobutyric acid catabolic process(GO:0009450)
0.3 1.3 GO:0006848 pyruvate transport(GO:0006848)
0.3 6.6 GO:0008645 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.3 1.6 GO:0044746 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.3 1.2 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
0.3 3.5 GO:0019740 nitrogen utilization(GO:0019740)
0.3 1.2 GO:0019748 secondary metabolic process(GO:0019748)
0.3 0.9 GO:0036257 multivesicular body organization(GO:0036257)
0.3 1.4 GO:0005980 glycogen catabolic process(GO:0005980)
0.3 4.6 GO:0042724 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.3 0.8 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.3 0.8 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.2 0.5 GO:0045980 negative regulation of nucleotide metabolic process(GO:0045980)
0.2 3.9 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.2 0.9 GO:0006598 polyamine catabolic process(GO:0006598)
0.2 0.7 GO:0010994 free ubiquitin chain polymerization(GO:0010994)
0.2 3.3 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.2 0.7 GO:0019541 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
0.2 0.2 GO:0045913 positive regulation of cellular carbohydrate metabolic process(GO:0010676) positive regulation of carbohydrate metabolic process(GO:0045913)
0.2 2.1 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.2 0.8 GO:0070054 mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response(GO:0030969) IRE1-mediated unfolded protein response(GO:0036498) mRNA splicing, via endonucleolytic cleavage and ligation(GO:0070054)
0.2 0.8 GO:0009410 response to xenobiotic stimulus(GO:0009410)
0.2 0.6 GO:0015888 thiamine transport(GO:0015888)
0.2 0.6 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.2 0.2 GO:0006559 L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.2 0.6 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.2 1.7 GO:0070987 error-free translesion synthesis(GO:0070987)
0.2 0.5 GO:0009107 lipoate metabolic process(GO:0009106) lipoate biosynthetic process(GO:0009107)
0.2 0.2 GO:0006108 malate metabolic process(GO:0006108)
0.2 1.1 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.2 0.6 GO:0015855 pyrimidine nucleobase transport(GO:0015855)
0.2 0.6 GO:0015976 carbon utilization(GO:0015976)
0.1 0.4 GO:0006824 cobalt ion transport(GO:0006824)
0.1 1.0 GO:0006083 acetate metabolic process(GO:0006083)
0.1 1.0 GO:0015891 siderophore transport(GO:0015891)
0.1 2.3 GO:0000209 protein polyubiquitination(GO:0000209)
0.1 0.7 GO:0034627 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.1 0.1 GO:0042816 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.1 0.3 GO:0006102 isocitrate metabolic process(GO:0006102)
0.1 0.6 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.1 0.6 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.1 0.2 GO:0015851 nucleobase transport(GO:0015851)
0.1 0.4 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
0.1 0.4 GO:0001678 cellular glucose homeostasis(GO:0001678) carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255) carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.1 0.2 GO:0015886 heme transport(GO:0015886)
0.1 0.5 GO:1903137 inactivation of MAPK activity involved in cell wall organization or biogenesis(GO:0000200) regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903137) negative regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903138) negative regulation of cell wall organization or biogenesis(GO:1903339)
0.1 1.5 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.1 1.3 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.1 0.8 GO:0061013 regulation of mRNA catabolic process(GO:0061013)
0.1 1.2 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 0.8 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.1 0.1 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.1 0.3 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.1 0.5 GO:0008053 mitochondrial fusion(GO:0008053)
0.1 0.1 GO:0005982 starch metabolic process(GO:0005982) starch catabolic process(GO:0005983) regulation of starch catabolic process by regulation of transcription from RNA polymerase II promoter(GO:0035956) positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0035957) regulation of starch catabolic process(GO:2000881) positive regulation of starch catabolic process(GO:2000883) regulation of starch metabolic process(GO:2000904) positive regulation of starch metabolic process(GO:2000906)
0.1 1.0 GO:0006101 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101)
0.1 0.3 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.1 0.7 GO:0015846 polyamine transport(GO:0015846)
0.1 0.3 GO:0017006 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.1 0.3 GO:0031138 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.1 0.5 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.1 0.5 GO:0000338 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.1 0.1 GO:2000219 positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter(GO:0036095) positive regulation of invasive growth in response to glucose limitation(GO:2000219)
0.1 1.3 GO:0006119 oxidative phosphorylation(GO:0006119)
0.1 0.4 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.1 0.8 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.1 0.3 GO:0016578 histone deubiquitination(GO:0016578)
0.1 1.4 GO:0006094 gluconeogenesis(GO:0006094)
0.1 2.8 GO:0009060 aerobic respiration(GO:0009060)
0.1 0.3 GO:0015793 glycerol transport(GO:0015793)
0.1 0.9 GO:0016925 protein sumoylation(GO:0016925)
0.1 0.3 GO:0015883 FAD transport(GO:0015883)
0.1 0.3 GO:0072479 cellular response to biotic stimulus(GO:0071216) response to cell cycle checkpoint signaling(GO:0072396) response to mitotic cell cycle checkpoint signaling(GO:0072414) response to spindle checkpoint signaling(GO:0072417) response to mitotic spindle checkpoint signaling(GO:0072476) response to mitotic cell cycle spindle assembly checkpoint signaling(GO:0072479) response to spindle assembly checkpoint signaling(GO:0072485) negative regulation of protein import into nucleus during spindle assembly checkpoint(GO:1901925)
0.1 0.3 GO:0006546 glycine catabolic process(GO:0006546)
0.1 0.7 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.1 0.3 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.1 0.2 GO:0061393 positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress(GO:0061393)
0.1 0.4 GO:0051181 cofactor transport(GO:0051181)
0.1 0.6 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.1 0.3 GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931)
0.1 0.1 GO:0044819 mitotic G1 DNA damage checkpoint(GO:0031571) mitotic G1/S transition checkpoint(GO:0044819)
0.1 0.6 GO:0031167 rRNA methylation(GO:0031167)
0.1 0.2 GO:0006527 arginine catabolic process(GO:0006527)
0.1 0.2 GO:0006739 NADP metabolic process(GO:0006739)
0.1 0.3 GO:0046688 response to copper ion(GO:0046688)
0.1 0.9 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.1 0.3 GO:0001927 exocyst assembly(GO:0001927)
0.1 0.3 GO:0006279 premeiotic DNA replication(GO:0006279)
0.1 0.4 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.1 0.5 GO:0046686 response to cadmium ion(GO:0046686)
0.1 0.2 GO:0098630 aggregation of unicellular organisms(GO:0098630) cell aggregation(GO:0098743)
0.1 0.2 GO:0030149 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.1 0.4 GO:0032447 protein urmylation(GO:0032447)
0.1 0.1 GO:0044783 G1 DNA damage checkpoint(GO:0044783)
0.1 0.4 GO:0006829 zinc II ion transport(GO:0006829)
0.1 0.2 GO:0031930 mitochondria-nucleus signaling pathway(GO:0031930)
0.1 0.2 GO:0051101 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
0.1 0.1 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.1 0.3 GO:0042732 D-xylose metabolic process(GO:0042732)
0.1 1.8 GO:0006312 mitotic recombination(GO:0006312)
0.1 0.2 GO:0032105 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.1 0.4 GO:0000755 cytogamy(GO:0000755)
0.1 0.2 GO:0070304 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.1 0.1 GO:0018209 peptidyl-serine phosphorylation(GO:0018105) peptidyl-serine modification(GO:0018209)
0.1 0.2 GO:0018065 protein-cofactor linkage(GO:0018065)
0.1 0.2 GO:0046113 nucleobase catabolic process(GO:0046113)
0.1 0.3 GO:0051260 protein homooligomerization(GO:0051260)
0.0 0.1 GO:0071168 protein localization to chromatin(GO:0071168)
0.0 0.4 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.0 0.2 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.0 0.1 GO:0043270 positive regulation of ion transport(GO:0043270)
0.0 0.4 GO:0015802 basic amino acid transport(GO:0015802)
0.0 0.1 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.0 0.1 GO:0034755 high-affinity iron ion transmembrane transport(GO:0006827) iron ion transmembrane transport(GO:0034755)
0.0 0.2 GO:0048209 regulation of COPII vesicle coating(GO:0003400) regulation of vesicle targeting, to, from or within Golgi(GO:0048209) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.0 0.2 GO:0043937 regulation of sporulation(GO:0043937)
0.0 1.6 GO:0070726 cell wall assembly(GO:0070726)
0.0 0.2 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.0 0.1 GO:0033499 galactose catabolic process(GO:0019388) galactose catabolic process via UDP-galactose(GO:0033499)
0.0 0.1 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.0 0.3 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.2 GO:0060237 regulation of fungal-type cell wall organization(GO:0060237)
0.0 0.4 GO:0001101 response to acid chemical(GO:0001101)
0.0 0.1 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.0 0.8 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.0 0.6 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.1 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.1 GO:0044209 AMP salvage(GO:0044209)
0.0 0.2 GO:0006768 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.0 0.2 GO:0006855 drug transmembrane transport(GO:0006855)
0.0 0.2 GO:0006816 calcium ion transport(GO:0006816)
0.0 0.1 GO:0046185 aldehyde catabolic process(GO:0046185)
0.0 0.1 GO:0019433 triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)
0.0 0.2 GO:0006276 plasmid maintenance(GO:0006276)
0.0 0.1 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 0.2 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.0 0.1 GO:0030007 cellular potassium ion homeostasis(GO:0030007) potassium ion homeostasis(GO:0055075)
0.0 0.5 GO:0001300 chronological cell aging(GO:0001300)
0.0 0.3 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.0 0.0 GO:0072350 tricarboxylic acid metabolic process(GO:0072350)
0.0 0.1 GO:0034764 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.0 0.1 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.0 0.1 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.1 GO:0019563 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.0 0.1 GO:0071825 lipid tube assembly(GO:0060988) protein-lipid complex assembly(GO:0065005) protein-lipid complex subunit organization(GO:0071825)
0.0 0.0 GO:0001178 regulation of transcriptional start site selection at RNA polymerase II promoter(GO:0001178)
0.0 0.1 GO:0000266 mitochondrial fission(GO:0000266) peroxisome fission(GO:0016559)
0.0 0.5 GO:1902534 membrane invagination(GO:0010324) lysosomal microautophagy(GO:0016237) single-organism membrane invagination(GO:1902534)
0.0 0.1 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.1 GO:0031032 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin structure organization(GO:0031032) actomyosin contractile ring organization(GO:0044837)
0.0 0.1 GO:0090110 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.1 GO:0006544 glycine metabolic process(GO:0006544) glycine biosynthetic process(GO:0006545)
0.0 0.2 GO:0006826 iron ion transport(GO:0006826)
0.0 0.0 GO:0032872 stress-activated protein kinase signaling cascade(GO:0031098) regulation of stress-activated MAPK cascade(GO:0032872) stress-activated MAPK cascade(GO:0051403) regulation of stress-activated protein kinase signaling cascade(GO:0070302)
0.0 0.1 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.1 GO:0070941 eisosome assembly(GO:0070941)
0.0 0.3 GO:0042026 protein refolding(GO:0042026)
0.0 0.1 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.0 GO:0009411 response to UV(GO:0009411) response to light stimulus(GO:0009416)
0.0 0.1 GO:0000023 maltose metabolic process(GO:0000023)
0.0 0.1 GO:0060194 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.0 0.1 GO:0006000 fructose metabolic process(GO:0006000)
0.0 0.1 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.1 GO:0032120 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.0 0.1 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.0 0.1 GO:0042766 nucleosome mobilization(GO:0042766)
0.0 0.2 GO:0007129 synapsis(GO:0007129)
0.0 0.1 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615) proton-transporting ATP synthase complex assembly(GO:0043461)
0.0 0.2 GO:0007118 budding cell apical bud growth(GO:0007118)
0.0 0.2 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.1 GO:0000132 establishment of mitotic spindle orientation(GO:0000132) establishment of mitotic spindle localization(GO:0040001) establishment of spindle orientation(GO:0051294)
0.0 0.0 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.0 0.0 GO:0035494 SNARE complex disassembly(GO:0035494)
0.0 0.1 GO:0033313 meiotic cell cycle checkpoint(GO:0033313) meiotic recombination checkpoint(GO:0051598)
0.0 0.4 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.2 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 0.5 GO:0007031 peroxisome organization(GO:0007031)
0.0 0.1 GO:0031120 snRNA pseudouridine synthesis(GO:0031120) snRNA modification(GO:0040031)
0.0 0.2 GO:0006999 nuclear pore organization(GO:0006999)
0.0 0.1 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.0 0.1 GO:0006077 (1->6)-beta-D-glucan metabolic process(GO:0006077)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.9 GO:0030287 cell wall-bounded periplasmic space(GO:0030287)
0.4 3.7 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.3 1.6 GO:0005771 multivesicular body(GO:0005771)
0.2 0.7 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.2 1.0 GO:0034448 EGO complex(GO:0034448)
0.2 1.5 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.2 0.4 GO:0030061 mitochondrial crista(GO:0030061)
0.2 1.3 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.2 0.5 GO:0005756 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
0.1 0.1 GO:0000974 Prp19 complex(GO:0000974)
0.1 3.7 GO:0070469 respiratory chain(GO:0070469)
0.1 0.3 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1 0.4 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.1 0.7 GO:0031932 TORC2 complex(GO:0031932)
0.1 0.3 GO:0005796 Golgi lumen(GO:0005796)
0.1 1.4 GO:0071012 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.1 0.3 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.1 0.4 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 0.6 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.1 0.3 GO:0005960 glycine cleavage complex(GO:0005960)
0.1 0.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 1.1 GO:0005619 ascospore wall(GO:0005619)
0.1 0.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.5 GO:0008180 COP9 signalosome(GO:0008180)
0.1 0.6 GO:0034657 GID complex(GO:0034657)
0.1 0.3 GO:0071819 DUBm complex(GO:0071819)
0.1 1.1 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.1 0.4 GO:0032126 eisosome(GO:0032126)
0.1 0.3 GO:0033309 SBF transcription complex(GO:0033309)
0.1 4.5 GO:0005576 extracellular region(GO:0005576)
0.1 7.3 GO:0098852 fungal-type vacuole membrane(GO:0000329) lytic vacuole membrane(GO:0098852)
0.1 0.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.4 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 3.7 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 0.3 GO:0032221 Rpd3S complex(GO:0032221)
0.1 0.2 GO:0000444 MIS12/MIND type complex(GO:0000444) nuclear MIS12/MIND complex(GO:0000818)
0.1 0.3 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.6 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.1 GO:0044284 mitochondrial crista junction(GO:0044284)
0.0 0.1 GO:0097002 mitochondrial inner boundary membrane(GO:0097002)
0.0 0.1 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.0 0.1 GO:0035649 Nrd1 complex(GO:0035649)
0.0 0.3 GO:0009277 fungal-type cell wall(GO:0009277)
0.0 0.2 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 0.2 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.5 GO:0031307 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.6 GO:0070847 core mediator complex(GO:0070847)
0.0 0.1 GO:0070274 RES complex(GO:0070274)
0.0 0.1 GO:0045334 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128) endocytic vesicle(GO:0030139) endocytic vesicle membrane(GO:0030666) clathrin-coated endocytic vesicle membrane(GO:0030669) clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.0 GO:0034099 luminal surveillance complex(GO:0034099)
0.0 0.1 GO:0000145 exocyst(GO:0000145)
0.0 0.8 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.4 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.2 GO:0005884 actin filament(GO:0005884)
0.0 0.1 GO:0032389 MutLalpha complex(GO:0032389)
0.0 0.3 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.0 GO:0030874 nucleolar chromatin(GO:0030874)
0.0 0.2 GO:0034967 Set3 complex(GO:0034967)
0.0 0.1 GO:0098573 integral component of mitochondrial membrane(GO:0032592) intrinsic component of mitochondrial membrane(GO:0098573)
0.0 0.1 GO:0098552 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.0 2.7 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.2 GO:0000795 synaptonemal complex(GO:0000795)
0.0 0.1 GO:0016587 Isw1 complex(GO:0016587)
0.0 0.2 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 5.7 GO:0005886 plasma membrane(GO:0005886)
0.0 0.5 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.1 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.1 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.1 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.7 GO:0000780 condensed nuclear chromosome, centromeric region(GO:0000780)
0.0 0.1 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.7 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 0.0 GO:0032301 MutSalpha complex(GO:0032301)
0.0 0.0 GO:0030286 dynein complex(GO:0030286)
0.0 0.6 GO:0005657 replication fork(GO:0005657)
0.0 0.2 GO:0016586 RSC complex(GO:0016586)
0.0 0.1 GO:0016514 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.6 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
1.7 6.7 GO:0005537 mannose binding(GO:0005537)
1.1 3.2 GO:0004564 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
1.0 3.9 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.8 5.5 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.7 2.8 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.7 4.0 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.7 2.0 GO:0005536 glucose binding(GO:0005536)
0.6 1.9 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.6 2.9 GO:0008198 ferrous iron binding(GO:0008198)
0.6 2.8 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.5 1.5 GO:0016289 CoA hydrolase activity(GO:0016289)
0.4 1.3 GO:0016406 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
0.4 1.3 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.4 1.3 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.4 5.7 GO:0015578 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.4 3.4 GO:0015294 solute:cation symporter activity(GO:0015294)
0.4 1.5 GO:0004396 hexokinase activity(GO:0004396)
0.4 4.1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.3 1.2 GO:0000772 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.3 1.2 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
0.3 0.9 GO:0016872 intramolecular lyase activity(GO:0016872)
0.3 3.4 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.2 1.0 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.2 2.6 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.2 3.3 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors(GO:0016645)
0.2 0.7 GO:0016405 CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
0.2 0.9 GO:0015603 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.2 0.7 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
0.2 0.9 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
0.2 0.6 GO:0003840 gamma-glutamyltransferase activity(GO:0003840)
0.2 1.0 GO:0019212 protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
0.2 1.0 GO:0050253 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.2 1.5 GO:0031072 heat shock protein binding(GO:0031072)
0.2 1.5 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.2 1.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 0.7 GO:0016531 copper chaperone activity(GO:0016531)
0.2 1.0 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.2 0.5 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.2 0.8 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.1 1.2 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 0.4 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.1 0.6 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.1 1.0 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.1 0.4 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 0.6 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.1 0.2 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.1 1.0 GO:0038023 transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) transmembrane receptor activity(GO:0099600)
0.1 2.2 GO:0008301 DNA binding, bending(GO:0008301)
0.1 0.8 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.1 0.5 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.1 0.3 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.1 1.2 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 0.1 GO:0042947 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.1 0.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.4 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.3 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.1 0.3 GO:0004362 glutathione-disulfide reductase activity(GO:0004362)
0.1 0.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.3 GO:0004180 carboxypeptidase activity(GO:0004180)
0.1 0.4 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.1 1.0 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.1 0.2 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.1 2.0 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 0.2 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.1 10.1 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.1 0.8 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.3 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.1 0.2 GO:0004458 D-lactate dehydrogenase (cytochrome) activity(GO:0004458)
0.1 0.2 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.1 0.1 GO:0016530 metallochaperone activity(GO:0016530)
0.1 0.4 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 0.2 GO:0003951 NAD+ kinase activity(GO:0003951) NADH kinase activity(GO:0042736)
0.1 0.3 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.1 0.5 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.1 0.2 GO:0045118 azole transporter activity(GO:0045118)
0.1 0.4 GO:0051184 cofactor transporter activity(GO:0051184)
0.1 0.2 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.1 0.9 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 0.2 GO:0015385 sodium:proton antiporter activity(GO:0015385)
0.1 0.1 GO:0015386 potassium:proton antiporter activity(GO:0015386) potassium ion antiporter activity(GO:0022821)
0.1 0.3 GO:0034318 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.1 0.2 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.1 0.2 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.1 0.3 GO:0070403 NAD+ binding(GO:0070403)
0.1 1.5 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.1 0.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.0 0.6 GO:0045182 translation regulator activity(GO:0045182)
0.0 0.4 GO:0015297 antiporter activity(GO:0015297)
0.0 0.7 GO:0016684 peroxidase activity(GO:0004601) oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)
0.0 0.1 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.0 0.1 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.2 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.2 GO:0016783 sulfurtransferase activity(GO:0016783)
0.0 0.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.1 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.0 0.3 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 0.6 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.1 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.0 0.5 GO:0051087 chaperone binding(GO:0051087)
0.0 0.3 GO:0016209 antioxidant activity(GO:0016209)
0.0 0.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.2 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.0 0.1 GO:0015085 calcium ion transmembrane transporter activity(GO:0015085)
0.0 0.1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.5 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.2 GO:0030295 protein kinase activator activity(GO:0030295)
0.0 0.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.3 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 1.2 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.1 GO:0042973 glucan endo-1,3-beta-D-glucosidase activity(GO:0042973)
0.0 0.1 GO:0005507 copper ion binding(GO:0005507)
0.0 0.1 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.1 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 0.4 GO:0008186 RNA-dependent ATPase activity(GO:0008186)
0.0 0.2 GO:0036459 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 0.0 GO:0032183 SUMO binding(GO:0032183)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 PID IL4 2PATHWAY IL4-mediated signaling events
0.3 0.9 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.3 0.8 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.3 0.5 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.1 0.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 0.5 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 0.3 PID NOTCH PATHWAY Notch signaling pathway
0.1 0.2 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.0 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.3 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.2 PID PLK1 PATHWAY PLK1 signaling events
0.0 46.4 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.4 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.2 0.5 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.2 1.6 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 1.7 REACTOME DNA REPAIR Genes involved in DNA Repair
0.1 0.2 REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE Genes involved in NFkB and MAP kinases activation mediated by TLR4 signaling repertoire
0.1 0.1 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.1 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.0 0.1 REACTOME INNATE IMMUNE SYSTEM Genes involved in Innate Immune System
0.0 0.1 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 46.3 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.1 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.0 0.1 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.0 REACTOME SIGNALING BY ERBB2 Genes involved in Signaling by ERBB2