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Results for GLN3

Z-value: 0.81

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Transcription factors associated with GLN3

Gene Symbol Gene ID Gene Info
GLN3
S000000842 Transcriptional activator of genes regulated by NCR

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GLN3YER040W0.723.6e-05Click!

Activity profile of GLN3 motif

Sorted Z-values of GLN3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YOR348C 10.54
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YER065C 8.69
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YPL054W 6.99
LEE1
Zinc-finger protein of unknown function
YLR307C-A 5.71 Putative protein of unknown function
YEL059W 5.10 Dubious open reading frame unlikely to encode a functional protein
YKR034W 5.07
DAL80
Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Deh1p
YIR027C 5.04
DAL1
Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression
YAR053W 4.92 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR107W 4.48
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YDL238C 4.37
GUD1
Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures
YJL133C-A 4.17 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YFL051C 4.15 Putative protein of unknown function; YFL051C is not an essential gene
YNL144C 3.87 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YDL210W 3.76
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YOR346W 3.73
REV1
Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YLR402W 3.60 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR306C-A 3.52 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR345C 3.51 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YGR087C 3.48
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YAR050W 3.44
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YLR142W 3.31
PUT1
Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
YAR060C 3.29 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR403W 3.24
SFP1
Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
YMR081C 3.14
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YGR032W 3.12
GSC2
Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
YMR040W 3.10
YET2
Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
YLR346C 3.05 Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene
YIR029W 2.96
DAL2
Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YJR152W 2.90
DAL5
Allantoin permease; ureidosuccinate permease; expression is constitutive but sensitive to nitrogen catabolite repression
YGR236C 2.88
SPG1
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKL103C 2.74
LAP4
Vacuolar aminopeptidase, often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway
YER150W 2.70
SPI1
GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YNL142W 2.65
MEP2
Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YDL169C 2.61
UGX2
Protein of unknown function, transcript accumulates in response to any combination of stress conditions
YHR139C 2.60
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YAR047C 2.58 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAL062W 2.51
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YOL082W 2.41
ATG19
Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; recognizes cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) and delivers them to the preautophagosomal structure for packaging into Cvt vesicles
YNL180C 2.39
RHO5
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
YKL102C 2.36 Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
YCR068W 2.35
ATG15
Lipase, required for intravacuolar lysis of autophagosomes; located in the endoplasmic reticulum membrane and targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway
YER014C-A 2.31
BUD25
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YNL179C 2.29 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
YDL067C 2.26
COX9
Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YLR356W 2.19 Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YGR268C 2.18
HUA1
Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
YNR002C 2.11
ATO2
Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p
YHR212C 2.08 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL217W 2.03
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YDL237W 2.01
LRC1
Putative protein of unknown function; YDL237W is not an essential gene; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YMR013C 2.00
SEC59
Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation
YGR088W 1.99
CTT1
Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YER121W 1.99 Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy
YHR212W-A 1.97 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YPR151C 1.96
SUE1
Mitochondrial protein required for degradation of unstable forms of cytochrome c
YNL143C 1.96 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YCL025C 1.94
AGP1
Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)
YEL012W 1.93
UBC8
Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
YPL089C 1.92
RLM1
MADS-box transcription factor, component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p
YIR028W 1.89
DAL4
Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YOR235W 1.85
IRC13
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci
YFL059W 1.80
SNZ3
Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO3
YAR019W-A 1.78 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIL125W 1.76
KGD1
Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA
YHR202W 1.75 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization
YAR035W 1.75
YAT1
Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
YDR034C 1.69
LYS14
Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
YNL195C 1.67 Putative protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR313C 1.67
PIB1
RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain
YOL118C 1.65 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YMR206W 1.62 Putative protein of unknown function; YMR206W is not an essential gene
YOR343C 1.61 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YNL101W 1.59
AVT4
Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YAR019C 1.59
CDC15
Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p
YLL056C 1.59 Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene
YBR077C 1.58
SLM4
Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
YNL240C 1.57
NAR1
Nuclear architecture related protein; component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins; homologous to human Narf
YIL146C 1.54
ECM37
Non-essential protein of unknown function
YHR082C 1.52
KSP1
Nonessential putative serine/threonine protein kinase of unknown cellular role; overproduction causes allele-specific suppression of the prp20-10 mutation
YKR102W 1.52
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YOL128C 1.49
YGK3
Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation
YDR036C 1.49
EHD3
3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis
YER066W 1.46 Putative protein of unknown function; YER066W is not an essential gene
YPL230W 1.46
USV1
Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in protein folding, ATP binding, and cell wall biosynthesis
YHR150W 1.45
PEX28
Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p
YKR033C 1.44 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80
YFL060C 1.43
SNO3
Protein of unknown function, nearly identical to Sno2p; expression is induced before the diauxic shift and also in the absence of thiamin
YGR144W 1.41
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YBL048W 1.41 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YEL059C-A 1.40
SOM1
Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates
YBR284W 1.39 Putative protein of unknown function; YBR284W is not an essential gene; null mutant exhibits decreased resistance to rapamycin and wortmannin
YBL049W 1.37
MOH1
Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase
YCR005C 1.37
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YJR038C 1.36 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR004C 1.35
SAG1
Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor
YLR037C 1.33
DAN2
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YHR211W 1.33
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YFR029W 1.33
PTR3
Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
YHL046W-A 1.31 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL170W 1.31
UGA3
Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus
YJR061W 1.31 Putative protein of unknown function; non-essential gene with similarity to Mnn4, a putative membrane protein involved in glycosylation; transcription repressed by Rm101p
YDR540C 1.30
IRC4
Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YHR006W 1.29
STP2
Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes
YAR023C 1.29 Putative integral membrane protein, member of DUP240 gene family
YNL295W 1.29 Putative protein of unknown function
YJR128W 1.26 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2
YDR022C 1.25
CIS1
Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion
YNL036W 1.24
NCE103
Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway
YNL176C 1.23 Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p
YLR296W 1.22 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR003W 1.22
YSP3
Putative precursor to the subtilisin-like protease III
YOR178C 1.22
GAC1
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YOR376W 1.21 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.
YBR145W 1.20
ADH5
Alcohol dehydrogenase isoenzyme V; involved in ethanol production
YMR271C 1.19
URA10
Minor orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; major OPRTase encoded by URA5
YHL047C 1.19
ARN2
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C
YER119C 1.19
AVT6
Vacuolar amino acid transporter, exports aspartate and glutamate from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YPL088W 1.19 Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
YPR196W 1.18 Putative maltose activator
YBL075C 1.18
SSA3
ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm
YPR013C 1.17 Putative zinc finger protein; YPR013C is not an essential gene
YMR103C 1.16 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR192C 1.16
THI72
Transporter of thiamine or related compound; shares sequence similarity with Thi7p
YBR209W 1.16 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR209W is not an essential gene
YPL134C 1.16
ODC1
Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation
YOR378W 1.16 Putative protein of unknown function; belongs to the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
YLL055W 1.15
YCT1
High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
YBR072W 1.14
HSP26
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YDL194W 1.14
SNF3
Plasma membrane glucose sensor that regulates glucose transport; has 12 predicted transmembrane segments; long cytoplasmic C-terminal tail is required for low glucose induction of hexose transporter genes HXT2 and HXT4
YJL166W 1.14
QCR8
Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
YLR004C 1.14
THI73
Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
YJL045W 1.14 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YMR014W 1.12
BUD22
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YNL125C 1.11
ESBP6
Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
YLR228C 1.11
ECM22
Sterol regulatory element binding protein, regulates transcription of the sterol biosynthetic genes ERG2 and ERG3; member of the fungus-specific Zn[2]-Cys[6] binuclear cluster family of transcription factors; homologous to Upc2p
YOR066W 1.10
MSA1
Activator of G1-specific transcription factors, MBF and SBF, that regulates both the timing of G1-specific gene transcription, and cell cycle initiation; potential Cdc28p substrate
YHR096C 1.09
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YDR342C 1.09
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YAL067C 1.09
SEO1
Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
YKL177W 1.08 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene STE3
YBR241C 1.08 Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene
YLR295C 1.08
ATP14
Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YNL314W 1.04
DAL82
Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
YFL019C 1.04 Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene
YAR069C 1.04 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL305C 1.03 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL305C is not an essential gene
YOR152C 1.03 Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YKL038W 1.01
RGT1
Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor
YDR119W-A 1.00 Putative protein of unknown function
YOR192C-C 1.00 Putative protein of unknown function; identified by expression profiling and mass spectrometry
YIL162W 1.00
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YPL114W 0.99 Dubious open reading frame, unlikely to encode a functional protein; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index
YDL138W 0.98
RGT2
Plasma membrane glucose receptor, highly similar to Snf3p; both Rgt2p and Snf3p serve as transmembrane glucose sensors generating an intracellular signal that induces expression of glucose transporter (HXT) genes
YAR070C 0.98 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOL119C 0.97
MCH4
Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YGR183C 0.97
QCR9
Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
YBL039W-B 0.97 Putative protein of unknown function
YML089C 0.96 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YPR065W 0.94
ROX1
Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity
YJL020C 0.94
BBC1
Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches
YCR011C 0.93
ADP1
Putative ATP-dependent permease of the ABC transporter family of proteins
YDR043C 0.92
NRG1
Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YHR217C 0.92 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; located in the telomeric region TEL08R.
YIL108W 0.91 Putative metalloprotease
YEL049W 0.89
PAU2
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YGR184C 0.89
UBR1
Ubiquitin-protein ligase (E3) that interacts with Rad6p/Ubc2p to ubiquitinate substrates of the N-end rule pathway; binds to the Rpn2p, Rpt1p, and Rpt6p proteins of the 19S particle of the 26S proteasome
YBR235W 0.88 Putative ion transporter, similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family; YBR235W is not an essential gene
YDR343C 0.88
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YMR135C 0.88
GID8
Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START
YJR146W 0.87 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2
YNR064C 0.87 Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides
YGL096W 0.86
TOS8
Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p
YOR344C 0.86
TYE7
Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression
YFL011W 0.85
HXT10
Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YPR120C 0.85
CLB5
B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase
YJL052W 0.85
TDH1
Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
YOR173W 0.84
DCS2
Non-essential, stress induced regulatory protein containing a HIT (histidine triad) motif; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway, similar to Dcs1p.
YBR208C 0.83
DUR1,2
Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YDR102C 0.83 Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index
YKR009C 0.83
FOX2
Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
YDR281C 0.82
PHM6
Protein of unknown function, expression is regulated by phosphate levels
YKL178C 0.82
STE3
Receptor for a factor receptor, transcribed in alpha cells and required for mating by alpha cells, couples to MAP kinase cascade to mediate pheromone response; ligand bound receptors are endocytosed and recycled to the plasma membrane; GPCR
YGR244C 0.80
LSC2
Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate
YIL088C 0.80
AVT7
Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YNL322C 0.79
KRE1
Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
YDR070C 0.79
FMP16
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDL223C 0.79
HBT1
Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
YMR279C 0.78 Putative protein of unknown function; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene
YFR045W 0.78 Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white
YBR179C 0.76
FZO1
Mitochondrial integral membrane protein involved in mitochondrial fusion and maintenance of the mitochondrial genome; contains N-terminal GTPase domain
YPR184W 0.76
GDB1
Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria
YGR213C 0.75
RTA1
Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions
YPR026W 0.75
ATH1
Acid trehalase required for utilization of extracellular trehalose
YKR046C 0.75
PET10
Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange
YNL296W 0.74 Dubious open reading frame unlikely to encode a functional protein; deletion adversely affects sporulation; deletion mutant exhibits synthetic phenotype under expression of mutant huntingtin fragment, but gene does not have human ortholog
YKL044W 0.74 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL094W 0.74
APP1
Protein of unknown function, interacts with Rvs161p and Rvs167p; computational analysis of protein-protein interactions in large-scale studies suggests a possible role in actin filament organization
YOR236W 0.74
DFR1
Dihydrofolate reductase, part of the dTTP biosynthetic pathway, involved in folate metabolism, possibly required for mitochondrial function
YER163C 0.74 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YGR281W 0.73
YOR1
Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin

Network of associatons between targets according to the STRING database.

First level regulatory network of GLN3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 11.1 GO:0015804 neutral amino acid transport(GO:0015804)
1.8 5.4 GO:0090295 nitrogen catabolite repression of transcription(GO:0090295)
1.5 4.4 GO:0046113 nucleobase catabolic process(GO:0046113)
1.4 10.1 GO:0000256 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256)
1.4 11.0 GO:0006097 glyoxylate cycle(GO:0006097)
1.2 4.6 GO:0015847 putrescine transport(GO:0015847)
1.1 6.9 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
1.1 3.3 GO:0010133 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
1.1 3.2 GO:0072488 ammonium transmembrane transport(GO:0072488)
1.0 3.9 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
0.9 3.7 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.8 2.4 GO:0036257 multivesicular body organization(GO:0036257)
0.7 2.1 GO:0051606 detection of chemical stimulus(GO:0009593) detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) detection of stimulus(GO:0051606)
0.7 2.0 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.6 3.8 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.6 0.6 GO:0072350 tricarboxylic acid metabolic process(GO:0072350)
0.6 1.7 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
0.6 2.8 GO:0032974 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.5 2.6 GO:0001080 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
0.5 1.5 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.5 2.0 GO:0006848 pyruvate transport(GO:0006848)
0.5 1.9 GO:0019748 secondary metabolic process(GO:0019748)
0.5 1.9 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.5 3.7 GO:0008614 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.4 2.1 GO:0032102 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.4 3.8 GO:0070987 error-free translesion synthesis(GO:0070987)
0.4 1.7 GO:0045764 positive regulation of cellular amino acid metabolic process(GO:0045764) positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.4 1.2 GO:0005993 trehalose catabolic process(GO:0005993)
0.4 1.2 GO:0015888 thiamine transport(GO:0015888)
0.4 0.4 GO:0018209 peptidyl-serine phosphorylation(GO:0018105) peptidyl-serine modification(GO:0018209)
0.4 0.4 GO:0019627 urea metabolic process(GO:0019627)
0.4 2.2 GO:0015851 nucleobase transport(GO:0015851)
0.4 1.4 GO:0043200 response to amino acid(GO:0043200)
0.4 1.4 GO:0015886 heme transport(GO:0015886)
0.3 1.4 GO:0032373 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.3 1.3 GO:0098630 aggregation of unicellular organisms(GO:0098630) cell aggregation(GO:0098743)
0.3 1.3 GO:0046323 glucose import(GO:0046323)
0.3 3.3 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.3 0.6 GO:0006102 isocitrate metabolic process(GO:0006102)
0.3 2.8 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.3 1.2 GO:0015976 carbon utilization(GO:0015976)
0.3 0.9 GO:0052652 cAMP biosynthetic process(GO:0006171) cyclic nucleotide biosynthetic process(GO:0009190) cyclic purine nucleotide metabolic process(GO:0052652)
0.3 1.2 GO:0019655 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
0.3 1.7 GO:0042407 cristae formation(GO:0042407)
0.3 3.1 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.3 2.8 GO:0042724 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.3 2.5 GO:0019740 nitrogen utilization(GO:0019740)
0.3 0.8 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
0.3 0.8 GO:0045981 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.3 1.8 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.3 2.0 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.2 0.7 GO:0061393 positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress(GO:0061393)
0.2 0.2 GO:0006108 malate metabolic process(GO:0006108)
0.2 0.7 GO:0006545 glycine biosynthetic process(GO:0006545)
0.2 0.7 GO:0019543 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
0.2 1.6 GO:0051322 anaphase(GO:0051322)
0.2 0.9 GO:0000736 double-strand break repair via single-strand annealing, removal of nonhomologous ends(GO:0000736)
0.2 0.9 GO:0071629 cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071629)
0.2 0.9 GO:0051225 spindle assembly(GO:0051225)
0.2 2.3 GO:0000272 polysaccharide catabolic process(GO:0000272)
0.2 1.0 GO:0015758 glucose transport(GO:0015758)
0.2 0.6 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.2 1.0 GO:0005985 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.2 1.2 GO:0010388 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.2 0.7 GO:0071331 cellular glucose homeostasis(GO:0001678) carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255) carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.2 0.9 GO:0008053 mitochondrial fusion(GO:0008053)
0.2 1.6 GO:0000196 MAPK cascade involved in cell wall organization or biogenesis(GO:0000196)
0.2 0.7 GO:0031297 replication fork processing(GO:0031297)
0.2 0.5 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.2 1.0 GO:0044205 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.2 0.5 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.2 0.6 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.2 0.3 GO:0061647 histone H3 acetylation(GO:0043966) histone H3-K9 acetylation(GO:0043970) histone H3-K14 acetylation(GO:0044154) histone H3-K9 modification(GO:0061647)
0.2 0.5 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.2 1.1 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.1 1.0 GO:0015891 siderophore transport(GO:0015891)
0.1 2.1 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.1 0.4 GO:0000304 response to singlet oxygen(GO:0000304)
0.1 0.5 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.1 1.2 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.1 0.4 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 0.4 GO:0070583 spore membrane bending pathway(GO:0070583)
0.1 0.4 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.1 0.6 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 0.6 GO:0043937 regulation of sporulation(GO:0043937)
0.1 0.4 GO:0043270 positive regulation of ion transport(GO:0043270)
0.1 0.5 GO:0015883 FAD transport(GO:0015883)
0.1 1.6 GO:0006098 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.1 0.2 GO:0010942 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.1 0.8 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.1 2.6 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.1 0.2 GO:0034762 regulation of transmembrane transport(GO:0034762)
0.1 0.2 GO:0006538 glutamate catabolic process(GO:0006538)
0.1 2.2 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 2.4 GO:0031503 protein complex localization(GO:0031503)
0.1 0.3 GO:0018063 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.1 1.7 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.1 0.3 GO:0006546 glycine catabolic process(GO:0006546)
0.1 4.7 GO:0009060 aerobic respiration(GO:0009060)
0.1 0.3 GO:0034398 telomere tethering at nuclear periphery(GO:0034398)
0.1 1.9 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 0.6 GO:0032120 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.1 0.6 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.1 1.1 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 0.5 GO:0046185 aldehyde catabolic process(GO:0046185)
0.1 0.2 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.1 0.3 GO:0000820 regulation of glutamine family amino acid metabolic process(GO:0000820) regulation of arginine metabolic process(GO:0000821)
0.1 0.8 GO:0018345 protein palmitoylation(GO:0018345)
0.1 0.4 GO:0006598 polyamine catabolic process(GO:0006598)
0.1 1.7 GO:0007129 synapsis(GO:0007129)
0.1 0.2 GO:0032006 regulation of TOR signaling(GO:0032006)
0.1 1.4 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.1 0.2 GO:0006750 glutathione biosynthetic process(GO:0006750) nonribosomal peptide biosynthetic process(GO:0019184)
0.1 0.5 GO:0043409 negative regulation of MAPK cascade(GO:0043409)
0.1 0.8 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.1 0.2 GO:0042148 strand invasion(GO:0042148)
0.1 0.3 GO:0000348 mRNA branch site recognition(GO:0000348)
0.1 1.3 GO:0001101 response to acid chemical(GO:0001101)
0.1 0.3 GO:0043269 regulation of ion transport(GO:0043269) regulation of anion transport(GO:0044070)
0.1 0.2 GO:0035459 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.1 0.4 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.1 0.9 GO:0000753 cell morphogenesis involved in conjugation with cellular fusion(GO:0000753) cell morphogenesis involved in conjugation(GO:0000767)
0.1 0.6 GO:0061188 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.1 0.2 GO:0010466 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
0.1 0.5 GO:0046686 response to cadmium ion(GO:0046686)
0.1 0.7 GO:0031167 rRNA methylation(GO:0031167)
0.1 2.5 GO:0070591 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
0.1 0.4 GO:0031990 mRNA export from nucleus in response to heat stress(GO:0031990)
0.1 0.2 GO:0050685 positive regulation of mRNA processing(GO:0050685)
0.1 0.3 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.1 0.3 GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931)
0.1 0.6 GO:0006801 superoxide metabolic process(GO:0006801)
0.1 0.7 GO:0045910 negative regulation of DNA recombination(GO:0045910)
0.1 0.3 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.1 0.2 GO:0070302 stress-activated protein kinase signaling cascade(GO:0031098) regulation of stress-activated MAPK cascade(GO:0032872) stress-activated MAPK cascade(GO:0051403) regulation of stress-activated protein kinase signaling cascade(GO:0070302)
0.1 1.2 GO:0016579 protein deubiquitination(GO:0016579)
0.1 0.2 GO:0051101 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
0.1 0.2 GO:0097271 protein autoubiquitination(GO:0051865) protein localization to bud neck(GO:0097271)
0.1 0.3 GO:0043954 cellular component maintenance(GO:0043954)
0.1 0.3 GO:0000266 mitochondrial fission(GO:0000266)
0.1 0.4 GO:0015893 drug transport(GO:0015893)
0.0 1.9 GO:1902534 membrane invagination(GO:0010324) lysosomal microautophagy(GO:0016237) single-organism membrane invagination(GO:1902534)
0.0 0.2 GO:0000023 maltose metabolic process(GO:0000023)
0.0 0.1 GO:0008272 sulfate transport(GO:0008272)
0.0 0.1 GO:0046039 GTP biosynthetic process(GO:0006183) GTP metabolic process(GO:0046039)
0.0 0.1 GO:0035753 maintenance of DNA trinucleotide repeats(GO:0035753)
0.0 0.5 GO:0015802 basic amino acid transport(GO:0015802)
0.0 0.1 GO:0009106 lipoate metabolic process(GO:0009106) lipoate biosynthetic process(GO:0009107)
0.0 0.1 GO:0046688 response to copper ion(GO:0046688)
0.0 0.3 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.2 GO:0051382 centromere complex assembly(GO:0034508) kinetochore assembly(GO:0051382) kinetochore organization(GO:0051383)
0.0 0.3 GO:0006829 zinc II ion transport(GO:0006829)
0.0 0.1 GO:0070932 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0 0.2 GO:0070131 regulation of mitochondrial translation(GO:0070129) positive regulation of mitochondrial translation(GO:0070131)
0.0 0.2 GO:0009231 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.0 0.1 GO:0010672 regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010672)
0.0 0.6 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 0.1 GO:0072593 reactive oxygen species metabolic process(GO:0072593)
0.0 0.1 GO:2000105 positive regulation of DNA-dependent DNA replication(GO:2000105)
0.0 0.2 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.0 0.1 GO:0018023 peptidyl-lysine trimethylation(GO:0018023)
0.0 0.2 GO:0006276 plasmid maintenance(GO:0006276)
0.0 0.1 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.3 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.0 0.2 GO:0060628 regulation of COPII vesicle coating(GO:0003400) regulation of vesicle targeting, to, from or within Golgi(GO:0048209) regulation of ER to Golgi vesicle-mediated transport(GO:0060628) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.0 0.2 GO:0007532 regulation of mating-type specific transcription, DNA-templated(GO:0007532)
0.0 0.1 GO:0010446 response to alkaline pH(GO:0010446) cellular response to pH(GO:0071467) cellular response to alkaline pH(GO:0071469)
0.0 0.1 GO:0070988 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.0 0.4 GO:0006094 gluconeogenesis(GO:0006094)
0.0 0.9 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.0 0.2 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0 0.3 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.0 0.1 GO:0051098 regulation of binding(GO:0051098)
0.0 0.3 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 0.1 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 0.2 GO:0006816 calcium ion transport(GO:0006816)
0.0 0.1 GO:0051181 cofactor transport(GO:0051181)
0.0 0.1 GO:0044783 G1 DNA damage checkpoint(GO:0044783)
0.0 0.1 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
0.0 0.1 GO:0051058 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.0 0.1 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.0 0.3 GO:0046834 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.1 GO:0019405 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.0 0.0 GO:0036010 protein localization to endosome(GO:0036010)
0.0 0.2 GO:0010525 regulation of transposition, RNA-mediated(GO:0010525)
0.0 0.1 GO:0042843 D-xylose catabolic process(GO:0042843)
0.0 0.1 GO:0070941 eisosome assembly(GO:0070941)
0.0 0.1 GO:0009250 glucan biosynthetic process(GO:0009250)
0.0 0.1 GO:0019400 glycerol metabolic process(GO:0006071) alditol metabolic process(GO:0019400)
0.0 0.0 GO:0006827 high-affinity iron ion transmembrane transport(GO:0006827)
0.0 0.1 GO:0040031 snRNA pseudouridine synthesis(GO:0031120) snRNA modification(GO:0040031)
0.0 0.2 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.2 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.0 GO:0032071 regulation of deoxyribonuclease activity(GO:0032070) regulation of endodeoxyribonuclease activity(GO:0032071)
0.0 0.2 GO:0008645 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.0 0.1 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.0 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0 0.0 GO:0009300 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.0 0.1 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0 0.0 GO:0009847 spore germination(GO:0009847)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.5 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.8 2.5 GO:0032585 multivesicular body membrane(GO:0032585)
0.6 1.9 GO:0009353 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.5 1.4 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.5 2.8 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.4 5.4 GO:0005619 ascospore wall(GO:0005619)
0.4 3.3 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.3 0.6 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.3 1.6 GO:0034448 EGO complex(GO:0034448)
0.3 0.8 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.2 0.7 GO:0005756 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
0.2 0.5 GO:0032126 eisosome(GO:0032126)
0.2 0.6 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.2 1.8 GO:0070069 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277) cytochrome complex(GO:0070069)
0.2 1.2 GO:0008180 COP9 signalosome(GO:0008180)
0.2 0.8 GO:0030287 cell wall-bounded periplasmic space(GO:0030287)
0.2 1.7 GO:0045263 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.2 0.5 GO:0005796 Golgi lumen(GO:0005796)
0.2 0.3 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.2 0.7 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.2 0.5 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.2 0.5 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.1 1.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 0.7 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.1 0.4 GO:0046930 pore complex(GO:0046930)
0.1 0.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 0.9 GO:0034657 GID complex(GO:0034657)
0.1 0.5 GO:0005825 half bridge of spindle pole body(GO:0005825)
0.1 0.4 GO:0030666 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128) endocytic vesicle(GO:0030139) endocytic vesicle membrane(GO:0030666) clathrin-coated endocytic vesicle membrane(GO:0030669) clathrin-coated endocytic vesicle(GO:0045334)
0.1 5.2 GO:0031225 anchored component of membrane(GO:0031225)
0.1 0.3 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.1 0.3 GO:0030874 nucleolar chromatin(GO:0030874)
0.1 0.3 GO:0005960 glycine cleavage complex(GO:0005960)
0.1 0.4 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 0.3 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.1 1.1 GO:0005769 early endosome(GO:0005769)
0.1 0.9 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.1 0.6 GO:0098562 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.1 0.7 GO:0000795 synaptonemal complex(GO:0000795)
0.1 0.3 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 0.5 GO:0033101 cellular bud membrane(GO:0033101)
0.1 0.3 GO:0071012 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.1 0.3 GO:0033309 SBF transcription complex(GO:0033309)
0.1 0.3 GO:0097002 mitochondrial inner boundary membrane(GO:0097002)
0.1 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.3 GO:0070772 PAS complex(GO:0070772)
0.1 0.2 GO:0051286 cell tip(GO:0051286)
0.1 4.3 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 0.7 GO:0005686 U2 snRNP(GO:0005686)
0.1 0.4 GO:0031499 TRAMP complex(GO:0031499)
0.1 1.0 GO:0005628 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.1 6.2 GO:0000329 fungal-type vacuole membrane(GO:0000329) lytic vacuole membrane(GO:0098852)
0.1 0.3 GO:0000839 Hrd1p ubiquitin ligase complex(GO:0000836) Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.2 GO:0005869 dynactin complex(GO:0005869)
0.0 0.5 GO:0030677 ribonuclease P complex(GO:0030677)
0.0 0.7 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.0 2.0 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.1 GO:0005784 Sec61 translocon complex(GO:0005784)
0.0 0.5 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.0 3.0 GO:0005774 vacuolar membrane(GO:0005774)
0.0 0.5 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.4 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 0.3 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.1 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.0 0.2 GO:0000439 nucleotide-excision repair factor 3 complex(GO:0000112) core TFIIH complex(GO:0000439)
0.0 0.1 GO:0072379 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.0 0.0 GO:0044284 mitochondrial crista junction(GO:0044284)
0.0 0.4 GO:0070210 Rpd3L-Expanded complex(GO:0070210)
0.0 0.1 GO:0070469 respiratory chain(GO:0070469)
0.0 0.3 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 2.7 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.1 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 0.3 GO:0016586 RSC complex(GO:0016586)
0.0 0.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.5 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.1 GO:0035649 Nrd1 complex(GO:0035649)
0.0 0.1 GO:0070775 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.0 0.2 GO:0000974 Prp19 complex(GO:0000974)
0.0 4.5 GO:0005886 plasma membrane(GO:0005886)
0.0 0.1 GO:0097196 Shu complex(GO:0097196)
0.0 0.0 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.1 GO:0035097 histone methyltransferase complex(GO:0035097) Set1C/COMPASS complex(GO:0048188)
0.0 0.5 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.5 GO:0005643 nuclear pore(GO:0005643)
0.0 0.1 GO:0032806 carboxy-terminal domain protein kinase complex(GO:0032806)
0.0 0.1 GO:0000118 histone deacetylase complex(GO:0000118)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 12.0 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
1.7 7.0 GO:0005537 mannose binding(GO:0005537)
1.6 4.8 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
1.2 3.7 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
1.1 7.7 GO:0016833 oxo-acid-lyase activity(GO:0016833)
1.0 3.9 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
1.0 5.8 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.9 2.6 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.7 2.1 GO:0005536 glucose binding(GO:0005536)
0.7 2.1 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
0.6 1.7 GO:0016406 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
0.5 4.9 GO:0015294 solute:cation symporter activity(GO:0015294)
0.5 1.6 GO:0016289 CoA hydrolase activity(GO:0016289)
0.5 1.6 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.5 2.5 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.5 2.4 GO:0004806 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.4 1.3 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.4 4.4 GO:0019239 deaminase activity(GO:0019239)
0.4 1.8 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.4 4.6 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.4 1.2 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.4 4.9 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.4 1.5 GO:0042927 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.4 3.0 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.4 2.9 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.3 4.7 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors(GO:0016645)
0.3 1.0 GO:0004575 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
0.3 1.5 GO:0008198 ferrous iron binding(GO:0008198)
0.3 1.2 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.3 0.8 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.2 0.2 GO:0042947 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.2 0.7 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.2 1.2 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.2 3.6 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.2 0.7 GO:0008972 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.2 1.1 GO:0004075 biotin carboxylase activity(GO:0004075)
0.2 0.7 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.2 2.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 0.8 GO:0005347 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
0.2 0.6 GO:0004458 D-lactate dehydrogenase (cytochrome) activity(GO:0004458)
0.2 0.8 GO:0016405 CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
0.2 0.4 GO:0001091 RNA polymerase II basal transcription factor binding(GO:0001091) TFIIH-class transcription factor binding(GO:0001097)
0.2 1.0 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.2 2.1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.2 0.7 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.2 0.9 GO:0017022 myosin binding(GO:0017022)
0.2 0.6 GO:0005078 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.2 0.7 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.2 1.8 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 4.1 GO:0008301 DNA binding, bending(GO:0008301)
0.2 1.0 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037) glutathione disulfide oxidoreductase activity(GO:0015038)
0.2 0.9 GO:0005354 galactose transmembrane transporter activity(GO:0005354)
0.2 7.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.2 0.6 GO:0016531 copper chaperone activity(GO:0016531)
0.2 2.0 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.2 0.5 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.1 1.2 GO:0031072 heat shock protein binding(GO:0031072)
0.1 0.4 GO:0033549 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.1 0.4 GO:0003840 gamma-glutamyltransferase activity(GO:0003840)
0.1 0.4 GO:0003951 NAD+ kinase activity(GO:0003951) NADH kinase activity(GO:0042736)
0.1 0.4 GO:0005253 anion channel activity(GO:0005253) voltage-gated anion channel activity(GO:0008308) porin activity(GO:0015288) wide pore channel activity(GO:0022829)
0.1 0.5 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 1.0 GO:0015297 antiporter activity(GO:0015297)
0.1 0.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 0.1 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 1.1 GO:0022838 substrate-specific channel activity(GO:0022838)
0.1 0.5 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.1 1.1 GO:0000293 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.1 0.3 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.1 0.6 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 0.4 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.1 0.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 0.5 GO:0008236 serine-type peptidase activity(GO:0008236)
0.1 0.3 GO:0004375 glycine dehydrogenase (decarboxylating) activity(GO:0004375) oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor(GO:0016642)
0.1 0.4 GO:0000156 phosphorelay response regulator activity(GO:0000156)
0.1 0.6 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.1 0.4 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 0.5 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.1 1.0 GO:0035064 methylated histone binding(GO:0035064)
0.1 0.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.3 GO:0004396 hexokinase activity(GO:0004396)
0.1 0.2 GO:0050136 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.3 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
0.1 0.3 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.1 0.7 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 0.2 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.1 0.1 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.1 0.2 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.3 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.1 1.0 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 0.4 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 0.4 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.1 4.5 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 0.2 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.1 0.2 GO:0000150 recombinase activity(GO:0000150)
0.1 1.1 GO:0019213 deacetylase activity(GO:0019213)
0.1 0.6 GO:0030983 mismatched DNA binding(GO:0030983)
0.1 0.3 GO:0004559 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.1 0.2 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 0.2 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 0.2 GO:0001128 RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly(GO:0001128)
0.0 0.1 GO:0015116 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.0 1.7 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.0 0.7 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 3.2 GO:0051082 unfolded protein binding(GO:0051082)
0.0 3.2 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 0.5 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.1 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.0 0.4 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0 0.3 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.0 0.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.2 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 0.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.6 GO:0101005 obsolete ubiquitin thiolesterase activity(GO:0004221) thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 0.2 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.5 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.3 GO:0042054 histone methyltransferase activity(GO:0042054)
0.0 0.2 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.0 0.1 GO:0008897 holo-[acyl-carrier-protein] synthase activity(GO:0008897)
0.0 0.1 GO:0001026 transcription factor activity, core RNA polymerase III binding(GO:0000995) TFIIIB-type transcription factor activity(GO:0001026)
0.0 0.1 GO:0015085 calcium ion transmembrane transporter activity(GO:0015085)
0.0 0.3 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.0 0.4 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.2 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.1 GO:0051184 cofactor transporter activity(GO:0051184)
0.0 0.1 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.0 0.1 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.1 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.0 0.0 GO:0032183 SUMO binding(GO:0032183)
0.0 0.3 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.0 GO:0015203 polyamine transmembrane transporter activity(GO:0015203)
0.0 0.1 GO:0000149 SNARE binding(GO:0000149)
0.0 0.2 GO:0004601 peroxidase activity(GO:0004601) oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)
0.0 0.0 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.0 0.1 GO:0005507 copper ion binding(GO:0005507)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.5 PID IL4 2PATHWAY IL4-mediated signaling events
0.3 0.8 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.2 1.0 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.2 0.5 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.2 0.3 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.1 0.1 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.1 0.4 PID P73PATHWAY p73 transcription factor network
0.1 0.1 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.1 0.2 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 0.5 PID FANCONI PATHWAY Fanconi anemia pathway
0.1 0.2 PID LKB1 PATHWAY LKB1 signaling events
0.1 78.6 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.1 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.0 PID ATF2 PATHWAY ATF-2 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.3 3.7 REACTOME DNA REPAIR Genes involved in DNA Repair
0.2 0.7 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.2 0.2 REACTOME PI3K EVENTS IN ERBB2 SIGNALING Genes involved in PI3K events in ERBB2 signaling
0.2 0.2 REACTOME SIGNALING BY ERBB2 Genes involved in Signaling by ERBB2
0.1 0.6 REACTOME MEIOSIS Genes involved in Meiosis
0.1 1.2 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 0.4 REACTOME INNATE IMMUNE SYSTEM Genes involved in Innate Immune System
0.1 0.1 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 0.5 REACTOME RNA POL II PRE TRANSCRIPTION EVENTS Genes involved in RNA Polymerase II Pre-transcription Events
0.1 0.6 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 78.6 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 0.3 REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES Genes involved in Transmembrane transport of small molecules
0.0 0.1 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)