Results for GIS1
Z-value: 2.69
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Transcription factors associated with GIS1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
GIS1
|
S000002503 | Histone demethylase and transcription factor |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YMR175W Show fit | 80.93 |
Protein of unknown function whose expression is induced by osmotic stress |
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| YHR139C Show fit | 59.93 |
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall |
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| YMR107W Show fit | 55.03 |
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources |
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| YGR087C Show fit | 54.44 |
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation |
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| YNR034W-A Show fit | 51.51 |
Putative protein of unknown function; expression is regulated by Msn2p/Msn4p |
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| YBR072W Show fit | 48.66 |
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells |
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| YOL052C-A Show fit | 46.76 |
Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses |
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| YOR393W Show fit | 46.55 |
Protein of unknown function, has similarity to enolases |
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| YKL217W Show fit | 43.66 |
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose |
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| YPL223C Show fit | 41.15 |
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway |
Network of associatons between targets according to the STRING database.
First level regulatory network of GIS1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.6 | 95.0 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 20.0 | 79.9 | GO:0071462 | response to water(GO:0009415) cellular response to water stimulus(GO:0071462) |
| 19.2 | 76.7 | GO:0006848 | pyruvate transport(GO:0006848) |
| 1.7 | 71.5 | GO:0070590 | ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940) |
| 8.9 | 62.3 | GO:0006083 | acetate metabolic process(GO:0006083) |
| 4.1 | 61.8 | GO:0005978 | glycogen biosynthetic process(GO:0005978) |
| 3.8 | 60.1 | GO:0006754 | ATP biosynthetic process(GO:0006754) |
| 7.3 | 58.6 | GO:0015758 | glucose transport(GO:0015758) |
| 5.8 | 57.5 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 2.4 | 57.0 | GO:0061726 | mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 408.8 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.8 | 123.2 | GO:0000323 | storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324) |
| 4.7 | 60.8 | GO:0005619 | ascospore wall(GO:0005619) |
| 4.8 | 57.4 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 3.1 | 55.4 | GO:0031306 | intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307) |
| 15.9 | 47.7 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 3.2 | 41.6 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.8 | 38.0 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 3.6 | 32.7 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 6.3 | 31.4 | GO:0045273 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 134.2 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 4.1 | 69.0 | GO:0046906 | heme binding(GO:0020037) tetrapyrrole binding(GO:0046906) |
| 4.8 | 67.7 | GO:0005353 | fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578) |
| 13.4 | 67.0 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 13.4 | 53.4 | GO:0004737 | pyruvate decarboxylase activity(GO:0004737) |
| 17.6 | 52.7 | GO:0004866 | endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414) |
| 15.9 | 47.7 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 13.5 | 40.6 | GO:0004555 | alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927) |
| 4.8 | 38.4 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 6.0 | 35.8 | GO:0004030 | aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 601.2 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 9.0 | 26.9 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 4.5 | 22.4 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 2.9 | 8.6 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 2.5 | 7.5 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 1.5 | 4.5 | PID FOXO PATHWAY | FoxO family signaling |
| 1.2 | 3.5 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.5 | 3.2 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 1.0 | 3.0 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 1.1 | 2.3 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 578.5 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 5.0 | 55.0 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |
| 10.7 | 32.0 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 4.0 | 8.1 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 2.0 | 5.9 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.5 | 4.1 | REACTOME MEIOSIS | Genes involved in Meiosis |
| 1.2 | 3.5 | REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE | Genes involved in MyD88:Mal cascade initiated on plasma membrane |
| 0.7 | 2.2 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.2 | 1.8 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.7 | 1.3 | REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE | Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle |