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Results for GAT1

Z-value: 1.55

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Transcription factors associated with GAT1

Gene Symbol Gene ID Gene Info
GAT1
S000001873 Transcriptional activator of genes involved in NCR

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GAT1YFL021W0.956.9e-14Click!

Activity profile of GAT1 motif

Sorted Z-values of GAT1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YDL210W 29.36
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YBL049W 25.01
MOH1
Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase
YAL062W 19.50
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YNL144C 19.10 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YPL054W 18.81
LEE1
Zinc-finger protein of unknown function
YOR348C 16.65
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YMR107W 16.15
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YNL142W 15.24
MEP2
Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YLR307C-A 14.29 Putative protein of unknown function
YER065C 14.25
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YAR053W 13.62 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKR034W 13.46
DAL80
Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Deh1p
YIR027C 12.48
DAL1
Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression
YLR142W 11.97
PUT1
Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
YEL059W 11.56 Dubious open reading frame unlikely to encode a functional protein
YGR087C 11.46
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YNL143C 11.29 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJR152W 10.63
DAL5
Allantoin permease; ureidosuccinate permease; expression is constitutive but sensitive to nitrogen catabolite repression
YDL238C 10.40
GUD1
Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures
YMR081C 9.96
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YAR060C 9.67 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR346W 9.34
REV1
Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YOR345C 9.02 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YMR206W 8.68 Putative protein of unknown function; YMR206W is not an essential gene
YIR029W 8.02
DAL2
Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YJL133C-A 7.92 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR402W 7.79 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR403W 7.35
SFP1
Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
YHR212C 7.12 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR346C 7.05 Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene
YKL103C 7.02
LAP4
Vacuolar aminopeptidase, often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway
YHR212W-A 7.02 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YAL061W 6.80
BDH2
Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; BDH2 is an essential gene
YIR028W 6.50
DAL4
Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YGR088W 6.34
CTT1
Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YLR312C 6.32
QNQ1
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YIL125W 6.25
KGD1
Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA
YIL162W 6.20
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YDR343C 6.18
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YCL025C 6.15
AGP1
Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)
YKL102C 6.15 Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
YCR068W 6.07
ATG15
Lipase, required for intravacuolar lysis of autophagosomes; located in the endoplasmic reticulum membrane and targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway
YAL063C 6.05
FLO9
Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
YDR043C 6.02
NRG1
Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YAR050W 5.94
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YPR010C-A 5.93 Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YGL180W 5.91
ATG1
Protein serine/threonine kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for pre-autophagosome formation; during autophagy forms a complex with Atg13p and Atg17p
YPR196W 5.86 Putative maltose activator
YDL169C 5.77
UGX2
Protein of unknown function, transcript accumulates in response to any combination of stress conditions
YDR119W-A 5.76 Putative protein of unknown function
YKL109W 5.60
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YOR376W 5.54 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.
YKL217W 5.41
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YMR244W 5.41 Putative protein of unknown function
YNL125C 5.35
ESBP6
Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
YBR208C 5.26
DUR1,2
Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YDL223C 5.25
HBT1
Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
YGR032W 5.23
GSC2
Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
YOL128C 5.12
YGK3
Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation
YDR536W 5.08
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YIL146C 5.06
ECM37
Non-essential protein of unknown function
YDR540C 5.04
IRC4
Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YKR102W 4.92
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YAL054C 4.90
ACS1
Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YER033C 4.89
ZRG8
Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency
YBR077C 4.89
SLM4
Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
YOR393W 4.87
ERR1
Protein of unknown function, has similarity to enolases
YKL163W 4.80
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YAR047C 4.71 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJR128W 4.61 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2
YGR121C 4.61
MEP1
Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YGR144W 4.60
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YOR343C 4.59 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YKL038W 4.57
RGT1
Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor
YDL182W 4.53
LYS20
Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys21p
YBR021W 4.53
FUR4
Uracil permease, localized to the plasma membrane; expression is tightly regulated by uracil levels and environmental cues
YDL138W 4.52
RGT2
Plasma membrane glucose receptor, highly similar to Snf3p; both Rgt2p and Snf3p serve as transmembrane glucose sensors generating an intracellular signal that induces expression of glucose transporter (HXT) genes
YBL073W 4.47 Hypothetical protein; open reading frame overlaps 5' end of essential AAR2 gene encoding a component of the U5 snRNP required for splicing of U3 precursors
YMR253C 4.26 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene
YBL074C 4.25
AAR2
Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron
YOR382W 4.22
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YFL021W 4.21
GAT1
Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p
YBR241C 4.19 Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene
YOL118C 4.17 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YGR236C 4.16
SPG1
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDL237W 4.14
LRC1
Putative protein of unknown function; YDL237W is not an essential gene; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YJL166W 4.09
QCR8
Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
YLL039C 4.07
UBI4
Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats
YPL150W 4.02 Putative protein kinase of unknown cellular role
YKR033C 4.01 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80
YOL060C 4.00
MAM3
Protein required for normal mitochondrial morphology, has similarity to hemolysins
YJL213W 3.99 Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p
YER014C-A 3.96
BUD25
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YDL067C 3.83
COX9
Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YOR235W 3.80
IRC13
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci
YBR182C 3.76
SMP1
Putative transcription factor involved in regulating the response to osmotic stress; member of the MADS-box family of transcription factors
YNL183C 3.76
NPR1
Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation
YCR091W 3.70
KIN82
Putative serine/threonine protein kinase, most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily
YMR170C 3.66
ALD2
Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p
YPR026W 3.65
ATH1
Acid trehalase required for utilization of extracellular trehalose
YFR053C 3.64
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YHL016C 3.63
DUR3
Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
YDR036C 3.61
EHD3
3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis
YJR146W 3.58 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2
YMR013C 3.56
SEC59
Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation
YLR047C 3.55
FRE8
Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p
YIL155C 3.55
GUT2
Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner
YLR004C 3.51
THI73
Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
YPL135W 3.51
ISU1
Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable
YNL101W 3.49
AVT4
Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YPL089C 3.49
RLM1
MADS-box transcription factor, component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p
YDL183C 3.44 Putative protein of unknown function; YDL183C is not an essential gene
YHR217C 3.43 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; located in the telomeric region TEL08R.
YOL082W 3.41
ATG19
Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; recognizes cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) and delivers them to the preautophagosomal structure for packaging into Cvt vesicles
YOR065W 3.40
CYT1
Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
YLR299W 3.38
ECM38
Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation
YCL001W-B 3.37 Putative protein of unknown function; identified by homology
YER121W 3.37 Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy
YDR313C 3.36
PIB1
RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain
YER188C-A 3.32 Putative protein of unknown function
YGR067C 3.31 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YKR039W 3.31
GAP1
General amino acid permease; localization to the plasma membrane is regulated by nitrogen source
YOR391C 3.29
HSP33
Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease
YFR029W 3.28
PTR3
Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
YAL067C 3.28
SEO1
Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
YER084W 3.27 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDL170W 3.20
UGA3
Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus
YLR304C 3.20
ACO1
Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy
YNL036W 3.19
NCE103
Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway
YER163C 3.15 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YOR003W 3.10
YSP3
Putative precursor to the subtilisin-like protease III
YGL096W 3.10
TOS8
Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p
YHR205W 3.10
SCH9
Protein kinase involved in transcriptional activation of osmostress-responsive genes; regulates G1 progression, cAPK activity, nitrogen activation of the FGM pathway; involved in life span regulation; homologous to mammalian Akt/PKB
YJR095W 3.10
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YHR006W 3.07
STP2
Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes
YHR202W 3.06 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization
YNL115C 3.05 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
YMR155W 3.05 Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen
YOR053W 3.04 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VHS3/YOR054C
YEL059C-A 3.03
SOM1
Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates
YNR034W 3.02
SOL1
Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol2p, Sol3p, and Sol4p
YER189W 2.99 Putative protein of unknown function
YKR096W 2.97 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc (PilT N terminus) domain
YJR004C 2.97
SAG1
Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor
YMR255W 2.94
GFD1
Coiled-coiled protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation
YMR280C 2.94
CAT8
Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements
YER079W 2.91 Putative protein of unknown function
YDL149W 2.87
ATG9
Transmembrane protein involved in formation of Cvt and autophagic vesicles; cycles between the pre-autophagosomal structure and other cytosolic punctate structures, not found in autophagosomes; forms a complex with Atg23p and Atg27p
YLR149C 2.85 Putative protein of unknown function; YLR149C is not an essential gene
YJL116C 2.83
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YEL012W 2.83
UBC8
Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
YEL060C 2.80
PRB1
Vacuolar proteinase B (yscB), a serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation
YMR194C-B 2.78 Putative protein of unknown function
YPR005C 2.77
HAL1
Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p
YAL034C 2.76
FUN19
Non-essential protein of unknown function
YHL036W 2.73
MUP3
Low affinity methionine permease, similar to Mup1p
YJL110C 2.72
GZF3
GATA zinc finger protein and Dal80p homolog that negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p
YPR138C 2.68
MEP3
Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease
YLR296W 2.66 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJR150C 2.65
DAN1
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YPR013C 2.63 Putative zinc finger protein; YPR013C is not an essential gene
YER088C 2.63
DOT6
Protein of unknown function, involved in telomeric gene silencing and filamentation
YMR254C 2.62 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBL078C 2.61
ATG8
Conserved protein that is a component of autophagosomes and Cvt vesicles; undergoes C-terminal conjugation to phosphatidylethanolamine (PE), Atg8p-PE is anchored to membranes and may mediate membrane fusion during autophagosome formation
YDL244W 2.59
THI13
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YMR154C 2.57
RIM13
Calpain-like cysteine protease involved in proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans palB
YJL144W 2.57 Cytoplasmic hydrophilin of unknown function, possibly involved in the dessication response; expression induced by osmotic stress, starvation and during stationary phase; GFP-fusion protein is induced by the DNA-damaging agent MMS
YGL033W 2.56
HOP2
Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
YLL056C 2.55 Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene
YER066W 2.54 Putative protein of unknown function; YER066W is not an essential gene
YDR436W 2.53
PPZ2
Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
YKR097W 2.50
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YPL151C 2.49
PRP46
Splicing factor that is found in the Cef1p subcomplex of the spliceosome
YOL119C 2.46
MCH4
Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YCR005C 2.46
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YGR183C 2.45
QCR9
Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
YDL139C 2.44
SCM3
Nonhistone component of centromeric chromatin that binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; contains nuclear export signal (NES); required for G2/M progression and localization of Cse4p
YBR139W 2.43 Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
YDL194W 2.42
SNF3
Plasma membrane glucose sensor that regulates glucose transport; has 12 predicted transmembrane segments; long cytoplasmic C-terminal tail is required for low glucose induction of hexose transporter genes HXT2 and HXT4
YPL088W 2.41 Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
YDR001C 2.40
NTH1
Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p
YPL134C 2.39
ODC1
Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation
YIR030C 2.38
DCG1
Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain
YOR066W 2.37
MSA1
Activator of G1-specific transcription factors, MBF and SBF, that regulates both the timing of G1-specific gene transcription, and cell cycle initiation; potential Cdc28p substrate
YLR342W 2.36
FKS1
Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling
YPR169W-A 2.35 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps two other dubious ORFs: YPR170C and YPR170W-B
YHR071W 2.34
PCL5
Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity
YFL051C 2.32 Putative protein of unknown function; YFL051C is not an essential gene
YDR379C-A 2.31 Hypothetical protein identified by homology. See FEBS Letters [2000] 487:31-36.
YLR273C 2.31
PIG1
Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase
YKR015C 2.31 Putative protein of unknown function
YOR344C 2.29
TYE7
Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression
YLL018C-A 2.26
COX19
Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase
YAR019W-A 2.26 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YEL074W 2.25 Hypothetical protein
YHR189W 2.22
PTH1
One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for cell growth and for mitochondrial respiration
YCR073W-A 2.21
SOL2
Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol1p, Sol3p, and Sol4p
YBL101C 2.21
ECM21
Non-essential protein of unknown function; promoter contains several Gcn4p binding elements
YLR259C 2.20
HSP60
Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated
YAR069C 2.18 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Network of associatons between targets according to the STRING database.

First level regulatory network of GAT1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
8.3 33.1 GO:0015847 putrescine transport(GO:0015847)
7.5 22.5 GO:0072488 ammonium transmembrane transport(GO:0072488)
5.4 16.2 GO:0090295 nitrogen catabolite repression of transcription(GO:0090295)
4.1 16.6 GO:0015804 neutral amino acid transport(GO:0015804)
4.0 12.1 GO:0006562 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
3.9 27.5 GO:0000256 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256)
3.1 12.4 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
3.1 9.2 GO:0019676 ammonia assimilation cycle(GO:0019676)
2.9 17.6 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
2.8 22.3 GO:0006097 glyoxylate cycle(GO:0006097)
2.8 8.3 GO:0046113 nucleobase catabolic process(GO:0046113)
2.3 6.9 GO:0009593 detection of chemical stimulus(GO:0009593) detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) detection of stimulus(GO:0051606)
2.1 6.3 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
2.1 6.2 GO:0036257 multivesicular body organization(GO:0036257)
2.0 6.0 GO:0005993 trehalose catabolic process(GO:0005993)
2.0 7.8 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
1.9 5.7 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
1.7 6.8 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
1.7 10.0 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
1.6 6.6 GO:0046323 glucose import(GO:0046323)
1.6 6.5 GO:0015855 pyrimidine nucleobase transport(GO:0015855)
1.6 8.1 GO:0001080 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
1.4 5.4 GO:0006848 pyruvate transport(GO:0006848)
1.2 6.0 GO:0032974 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
1.1 11.4 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
1.1 10.2 GO:0070987 error-free translesion synthesis(GO:0070987)
1.1 3.4 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
1.1 7.8 GO:0007532 regulation of mating-type specific transcription, DNA-templated(GO:0007532)
1.1 2.2 GO:0006538 glutamate catabolic process(GO:0006538)
1.0 1.0 GO:0046487 glyoxylate metabolic process(GO:0046487)
1.0 4.2 GO:0043200 response to amino acid(GO:0043200)
1.0 5.2 GO:0015793 glycerol transport(GO:0015793)
1.0 3.0 GO:0015740 C4-dicarboxylate transport(GO:0015740)
1.0 5.1 GO:0032102 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
1.0 6.7 GO:0034762 regulation of transmembrane transport(GO:0034762)
1.0 2.9 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.9 3.7 GO:0006598 polyamine catabolic process(GO:0006598)
0.9 3.6 GO:0015976 carbon utilization(GO:0015976)
0.9 3.4 GO:0019563 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.9 4.3 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.8 5.0 GO:0006085 acetyl-CoA biosynthetic process(GO:0006085)
0.8 6.6 GO:0005985 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.8 2.4 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.8 4.0 GO:0015851 nucleobase transport(GO:0015851)
0.8 2.3 GO:0051222 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
0.8 1.6 GO:0006102 isocitrate metabolic process(GO:0006102)
0.8 3.8 GO:0015758 glucose transport(GO:0015758)
0.8 6.1 GO:0015891 siderophore transport(GO:0015891)
0.7 11.1 GO:1905037 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.7 3.0 GO:0098630 aggregation of unicellular organisms(GO:0098630) cell aggregation(GO:0098743)
0.7 10.6 GO:0072350 tricarboxylic acid metabolic process(GO:0072350)
0.7 2.1 GO:0045764 positive regulation of cellular amino acid metabolic process(GO:0045764) positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.7 2.0 GO:0006545 glycine biosynthetic process(GO:0006545)
0.7 11.4 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.7 1.3 GO:0045981 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.7 2.0 GO:0006546 glycine catabolic process(GO:0006546)
0.7 5.9 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.6 8.7 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.6 3.1 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.6 2.4 GO:0097271 protein localization to bud neck(GO:0097271)
0.6 1.8 GO:0001178 regulation of transcriptional start site selection at RNA polymerase II promoter(GO:0001178)
0.6 1.7 GO:0009190 cAMP biosynthetic process(GO:0006171) cyclic nucleotide biosynthetic process(GO:0009190) cyclic purine nucleotide metabolic process(GO:0052652)
0.6 4.0 GO:0030026 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.6 8.0 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.6 1.7 GO:0045991 carbon catabolite activation of transcription(GO:0045991)
0.6 0.6 GO:0018209 peptidyl-serine phosphorylation(GO:0018105) peptidyl-serine modification(GO:0018209)
0.5 4.9 GO:0000272 polysaccharide catabolic process(GO:0000272)
0.5 7.1 GO:0015749 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.5 3.7 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.5 5.2 GO:0006119 oxidative phosphorylation(GO:0006119)
0.5 3.1 GO:0010388 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.5 1.0 GO:0046321 regulation of fatty acid beta-oxidation(GO:0031998) positive regulation of fatty acid beta-oxidation(GO:0032000) regulation of fatty acid oxidation(GO:0046320) positive regulation of fatty acid oxidation(GO:0046321)
0.5 0.5 GO:0046352 disaccharide catabolic process(GO:0046352)
0.5 4.0 GO:0070873 regulation of glycogen biosynthetic process(GO:0005979) regulation of glycogen metabolic process(GO:0070873)
0.5 1.4 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.5 1.9 GO:0071629 cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071629)
0.5 7.2 GO:0006098 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.5 3.4 GO:0015846 polyamine transport(GO:0015846)
0.5 2.8 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.5 1.4 GO:0017003 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.5 1.4 GO:0043335 protein unfolding(GO:0043335)
0.5 1.8 GO:0051101 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
0.4 0.9 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.4 2.6 GO:0042407 cristae formation(GO:0042407)
0.4 1.3 GO:0010466 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
0.4 0.9 GO:0008272 sulfate transport(GO:0008272)
0.4 3.5 GO:0045332 phospholipid translocation(GO:0045332)
0.4 1.3 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
0.4 6.2 GO:0000767 cell morphogenesis involved in conjugation(GO:0000767)
0.4 1.2 GO:0010994 free ubiquitin chain polymerization(GO:0010994)
0.4 2.4 GO:0061393 positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress(GO:0061393)
0.4 3.1 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.4 1.9 GO:0008053 mitochondrial fusion(GO:0008053)
0.4 5.4 GO:0000209 protein polyubiquitination(GO:0000209)
0.4 1.5 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.4 1.5 GO:0001881 receptor recycling(GO:0001881) protein import into peroxisome matrix, receptor recycling(GO:0016562) receptor metabolic process(GO:0043112)
0.4 1.5 GO:0031297 replication fork processing(GO:0031297)
0.4 3.7 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.4 1.5 GO:0071331 cellular glucose homeostasis(GO:0001678) carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255) carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.4 0.7 GO:0071469 response to alkaline pH(GO:0010446) cellular response to pH(GO:0071467) cellular response to alkaline pH(GO:0071469)
0.4 2.1 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.4 3.5 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.3 13.2 GO:0009060 aerobic respiration(GO:0009060)
0.3 0.3 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993)
0.3 2.0 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.3 1.7 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.3 3.0 GO:0000196 MAPK cascade involved in cell wall organization or biogenesis(GO:0000196)
0.3 0.7 GO:0000820 regulation of glutamine family amino acid metabolic process(GO:0000820) regulation of arginine metabolic process(GO:0000821)
0.3 2.9 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.3 1.3 GO:0009102 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.3 1.3 GO:0009300 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.3 5.4 GO:0007129 synapsis(GO:0007129)
0.3 3.5 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.3 0.9 GO:0006592 ornithine biosynthetic process(GO:0006592)
0.3 1.5 GO:0051274 beta-glucan biosynthetic process(GO:0051274)
0.3 0.9 GO:0031138 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.3 1.4 GO:0034627 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.3 0.9 GO:0006527 arginine catabolic process(GO:0006527)
0.3 1.1 GO:0046688 response to copper ion(GO:0046688)
0.3 1.6 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.3 1.6 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.3 1.1 GO:0046185 aldehyde catabolic process(GO:0046185)
0.3 0.5 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
0.3 1.8 GO:0051322 anaphase(GO:0051322)
0.3 0.3 GO:0042542 response to hydrogen peroxide(GO:0042542)
0.3 0.5 GO:0015691 cadmium ion transport(GO:0015691)
0.2 1.2 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.2 0.5 GO:0035494 SNARE complex disassembly(GO:0035494)
0.2 1.2 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.2 0.7 GO:0006741 NADP biosynthetic process(GO:0006741)
0.2 0.7 GO:0070583 spore membrane bending pathway(GO:0070583)
0.2 0.2 GO:0034225 cellular response to zinc ion starvation(GO:0034224) regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation(GO:0034225)
0.2 0.4 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.2 1.3 GO:0046777 protein autophosphorylation(GO:0046777)
0.2 1.6 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.2 1.4 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.2 0.6 GO:0044783 G1 DNA damage checkpoint(GO:0044783)
0.2 0.6 GO:0032071 regulation of deoxyribonuclease activity(GO:0032070) regulation of endodeoxyribonuclease activity(GO:0032071)
0.2 1.4 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.2 0.8 GO:0006482 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.2 3.5 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.2 0.7 GO:0009410 response to xenobiotic stimulus(GO:0009410)
0.2 0.9 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.2 0.7 GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931)
0.2 1.0 GO:0006621 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.2 0.2 GO:0009450 gamma-aminobutyric acid metabolic process(GO:0009448) gamma-aminobutyric acid catabolic process(GO:0009450)
0.2 1.6 GO:0045144 meiosis II(GO:0007135) meiotic sister chromatid segregation(GO:0045144)
0.2 0.5 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.2 1.8 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.2 1.9 GO:0042026 protein refolding(GO:0042026)
0.2 1.0 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.2 1.3 GO:0018345 protein palmitoylation(GO:0018345)
0.2 0.8 GO:0019722 calcium-mediated signaling(GO:0019722)
0.2 1.5 GO:0016925 protein sumoylation(GO:0016925)
0.1 3.7 GO:0016485 protein processing(GO:0016485)
0.1 0.3 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.1 0.4 GO:0009411 response to UV(GO:0009411)
0.1 0.8 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 1.0 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.1 2.5 GO:0016579 protein deubiquitination(GO:0016579)
0.1 0.3 GO:0015867 ATP transport(GO:0015867)
0.1 0.4 GO:0015693 magnesium ion transport(GO:0015693)
0.1 0.2 GO:0071169 establishment of protein localization to chromosome(GO:0070199) establishment of protein localization to chromatin(GO:0071169)
0.1 0.6 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.1 0.3 GO:1902932 positive regulation of cellular amine metabolic process(GO:0033240) positive regulation of alcohol biosynthetic process(GO:1902932)
0.1 0.7 GO:0006276 plasmid maintenance(GO:0006276)
0.1 0.2 GO:0019748 secondary metabolic process(GO:0019748)
0.1 0.7 GO:0046686 response to cadmium ion(GO:0046686)
0.1 1.1 GO:0051181 cofactor transport(GO:0051181)
0.1 0.6 GO:0006816 calcium ion transport(GO:0006816)
0.1 2.6 GO:0010324 membrane invagination(GO:0010324) lysosomal microautophagy(GO:0016237) single-organism membrane invagination(GO:1902534)
0.1 1.2 GO:0001101 response to acid chemical(GO:0001101)
0.1 1.6 GO:0015918 sterol transport(GO:0015918)
0.1 0.6 GO:0006452 translational frameshifting(GO:0006452)
0.1 0.8 GO:0042766 nucleosome mobilization(GO:0042766)
0.1 0.2 GO:0050685 positive regulation of mRNA processing(GO:0050685)
0.1 0.3 GO:0001308 negative regulation of chromatin silencing involved in replicative cell aging(GO:0001308)
0.1 0.5 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491)
0.1 0.1 GO:0009847 spore germination(GO:0009847)
0.1 0.4 GO:0070932 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.1 0.4 GO:0031578 mitotic spindle orientation checkpoint(GO:0031578)
0.1 0.3 GO:0072348 sulfur compound transport(GO:0072348)
0.1 0.2 GO:0090110 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.1 0.4 GO:0070058 tRNA gene clustering(GO:0070058)
0.1 0.1 GO:0090630 activation of GTPase activity(GO:0090630)
0.1 0.4 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.1 0.4 GO:0000266 mitochondrial fission(GO:0000266)
0.1 0.4 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 0.2 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.1 0.4 GO:0070096 mitochondrial outer membrane translocase complex assembly(GO:0070096)
0.1 3.4 GO:0071427 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.1 0.2 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 0.5 GO:0045005 DNA-dependent DNA replication maintenance of fidelity(GO:0045005)
0.1 0.1 GO:0045117 azole transport(GO:0045117)
0.1 0.8 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.1 0.4 GO:0046854 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.1 0.3 GO:0018065 protein-cofactor linkage(GO:0018065)
0.0 1.3 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.0 0.2 GO:1902707 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
0.0 0.2 GO:0018023 peptidyl-lysine trimethylation(GO:0018023)
0.0 0.1 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.0 0.5 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0 0.4 GO:0072511 divalent metal ion transport(GO:0070838) divalent inorganic cation transport(GO:0072511)
0.0 0.4 GO:0045910 negative regulation of DNA recombination(GO:0045910)
0.0 0.2 GO:0000161 MAPK cascade involved in osmosensory signaling pathway(GO:0000161)
0.0 0.2 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.1 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.0 0.3 GO:0046173 polyol biosynthetic process(GO:0046173)
0.0 0.4 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.3 GO:0090522 vesicle tethering involved in exocytosis(GO:0090522)
0.0 0.3 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.0 0.1 GO:0036010 protein localization to endosome(GO:0036010)
0.0 1.0 GO:0007031 peroxisome organization(GO:0007031)
0.0 0.1 GO:0071044 histone mRNA metabolic process(GO:0008334) histone mRNA catabolic process(GO:0071044) snoRNA polyadenylation(GO:0071050)
0.0 0.1 GO:0006000 fructose metabolic process(GO:0006000)
0.0 0.1 GO:0045807 positive regulation of endocytosis(GO:0045807)
0.0 0.1 GO:0043937 regulation of sporulation(GO:0043937)
0.0 0.2 GO:0030242 pexophagy(GO:0030242)
0.0 0.6 GO:0022900 electron transport chain(GO:0022900)
0.0 0.2 GO:0045143 homologous chromosome segregation(GO:0045143)
0.0 0.1 GO:0006655 phosphatidylglycerol biosynthetic process(GO:0006655)
0.0 0.2 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.1 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.0 0.2 GO:0007118 budding cell apical bud growth(GO:0007118)
0.0 0.1 GO:0030007 cellular potassium ion homeostasis(GO:0030007) potassium ion homeostasis(GO:0055075)
0.0 0.2 GO:0031145 anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.0 0.1 GO:0030100 regulation of endocytosis(GO:0030100)
0.0 0.1 GO:0009202 deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
0.0 0.1 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.3 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.0 0.0 GO:0071036 snRNA catabolic process(GO:0016076) snoRNA catabolic process(GO:0016077) nuclear polyadenylation-dependent snoRNA catabolic process(GO:0071036) nuclear polyadenylation-dependent snRNA catabolic process(GO:0071037)
0.0 0.1 GO:0022406 membrane docking(GO:0022406)
0.0 0.1 GO:0034401 chromatin organization involved in regulation of transcription(GO:0034401)
0.0 0.0 GO:0031292 gene conversion at mating-type locus, DNA double-strand break processing(GO:0031292)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 6.8 GO:0009353 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
2.1 6.3 GO:0032585 multivesicular body membrane(GO:0032585)
2.0 5.9 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
1.9 7.6 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
1.7 3.3 GO:0005771 multivesicular body(GO:0005771)
1.4 5.7 GO:0016602 CCAAT-binding factor complex(GO:0016602)
1.3 11.7 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
1.2 3.7 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
1.1 5.3 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
1.0 3.0 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.9 2.6 GO:0032176 split septin rings(GO:0032176) cellular bud neck split septin rings(GO:0032177)
0.8 4.1 GO:0034448 EGO complex(GO:0034448)
0.8 1.6 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.7 2.0 GO:0005960 glycine cleavage complex(GO:0005960)
0.6 8.4 GO:0005619 ascospore wall(GO:0005619)
0.6 1.8 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.6 1.1 GO:0030061 mitochondrial crista(GO:0030061)
0.6 4.5 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.5 1.6 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.5 3.1 GO:0008180 COP9 signalosome(GO:0008180)
0.5 1.5 GO:0030874 nucleolar chromatin(GO:0030874)
0.5 1.4 GO:0005756 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
0.4 3.0 GO:0034657 GID complex(GO:0034657)
0.4 1.3 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.4 0.8 GO:0097002 mitochondrial inner boundary membrane(GO:0097002)
0.4 1.2 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.4 1.5 GO:0071012 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.4 3.6 GO:0000974 Prp19 complex(GO:0000974)
0.4 3.2 GO:0070069 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277) cytochrome complex(GO:0070069)
0.3 1.4 GO:0098552 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.3 4.2 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.3 2.7 GO:0000795 synaptonemal complex(GO:0000795)
0.3 1.2 GO:0030287 cell wall-bounded periplasmic space(GO:0030287)
0.3 1.5 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.3 1.2 GO:0030666 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128) endocytic vesicle(GO:0030139) endocytic vesicle membrane(GO:0030666) clathrin-coated endocytic vesicle membrane(GO:0030669) clathrin-coated endocytic vesicle(GO:0045334)
0.3 1.4 GO:0098803 mitochondrial respiratory chain(GO:0005746) respiratory chain complex(GO:0098803)
0.3 2.5 GO:0045263 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.3 1.4 GO:0032221 Rpd3S complex(GO:0032221)
0.3 1.0 GO:0000444 MIS12/MIND type complex(GO:0000444) nuclear MIS12/MIND complex(GO:0000818)
0.2 3.7 GO:0005682 U5 snRNP(GO:0005682)
0.2 29.6 GO:0000329 fungal-type vacuole membrane(GO:0000329) lytic vacuole membrane(GO:0098852)
0.2 0.7 GO:0005796 Golgi lumen(GO:0005796)
0.2 2.6 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2 0.6 GO:0030870 Mre11 complex(GO:0030870)
0.2 0.9 GO:0070775 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.2 0.4 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.2 1.7 GO:0033698 Rpd3L complex(GO:0033698)
0.2 2.4 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.2 0.7 GO:0033309 SBF transcription complex(GO:0033309)
0.2 0.5 GO:0030896 checkpoint clamp complex(GO:0030896)
0.2 1.8 GO:0005686 U2 snRNP(GO:0005686)
0.1 7.1 GO:0031225 anchored component of membrane(GO:0031225)
0.1 1.6 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.1 0.4 GO:0032301 MutSalpha complex(GO:0032301)
0.1 1.6 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.1 2.1 GO:0031305 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.1 0.6 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 1.6 GO:0000124 SAGA complex(GO:0000124)
0.1 1.7 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.1 2.0 GO:0031307 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.1 5.7 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 0.5 GO:0098573 integral component of mitochondrial membrane(GO:0032592) intrinsic component of mitochondrial membrane(GO:0098573)
0.1 0.4 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 1.7 GO:0042764 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.1 0.8 GO:0005769 early endosome(GO:0005769)
0.1 0.3 GO:0001400 mating projection base(GO:0001400)
0.1 0.6 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.1 0.6 GO:0000439 nucleotide-excision repair factor 3 complex(GO:0000112) core TFIIH complex(GO:0000439)
0.1 0.6 GO:0035097 histone methyltransferase complex(GO:0035097) Set1C/COMPASS complex(GO:0048188)
0.1 0.7 GO:0031011 Ino80 complex(GO:0031011)
0.1 0.3 GO:0031207 endoplasmic reticulum Sec complex(GO:0031205) Sec62/Sec63 complex(GO:0031207)
0.1 22.2 GO:0005886 plasma membrane(GO:0005886)
0.1 0.6 GO:0005818 astral microtubule(GO:0000235) aster(GO:0005818)
0.1 0.2 GO:0032116 SMC loading complex(GO:0032116)
0.1 0.2 GO:0033551 monopolin complex(GO:0033551)
0.1 0.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.5 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 3.9 GO:0044437 vacuolar part(GO:0044437)
0.1 2.0 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 0.1 GO:0070274 RES complex(GO:0070274)
0.0 0.3 GO:0031499 TRAMP complex(GO:0031499)
0.0 0.4 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.2 GO:0005825 half bridge of spindle pole body(GO:0005825)
0.0 0.1 GO:0051286 cell tip(GO:0051286)
0.0 1.9 GO:0043332 mating projection tip(GO:0043332)
0.0 1.2 GO:0005643 nuclear pore(GO:0005643)
0.0 0.1 GO:0000837 Doa10p ubiquitin ligase complex(GO:0000837)
0.0 0.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.6 GO:0016592 mediator complex(GO:0016592)
0.0 0.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.2 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.5 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 1.8 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.2 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.1 GO:0008623 CHRAC(GO:0008623)
0.0 0.1 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.3 GO:0030479 actin cortical patch(GO:0030479) endocytic patch(GO:0061645)
0.0 0.2 GO:0000118 histone deacetylase complex(GO:0000118)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
11.1 33.4 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
6.5 26.1 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
4.6 18.3 GO:0005537 mannose binding(GO:0005537)
3.1 12.4 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
2.8 11.0 GO:0015295 solute:proton symporter activity(GO:0015295)
2.5 7.6 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
2.3 14.0 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
2.3 6.9 GO:0005536 glucose binding(GO:0005536)
2.3 9.2 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
2.2 11.0 GO:0015294 solute:cation symporter activity(GO:0015294)
2.2 6.5 GO:0004564 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
2.0 6.0 GO:0004555 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
1.8 12.5 GO:0016833 oxo-acid-lyase activity(GO:0016833)
1.8 5.3 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
1.7 5.2 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
1.7 6.8 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
1.7 5.0 GO:0016208 AMP binding(GO:0016208)
1.6 4.9 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
1.6 6.4 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
1.5 16.7 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
1.5 19.5 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
1.5 7.3 GO:0008198 ferrous iron binding(GO:0008198)
1.3 3.9 GO:0016289 CoA hydrolase activity(GO:0016289)
1.3 5.1 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
1.2 3.7 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
1.2 6.1 GO:0050253 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
1.1 3.3 GO:0003840 gamma-glutamyltransferase activity(GO:0003840)
1.0 8.3 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
1.0 5.2 GO:0004075 biotin carboxylase activity(GO:0004075)
1.0 3.0 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.9 4.5 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.9 12.3 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors(GO:0016645)
0.9 3.4 GO:0005186 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.8 2.4 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.8 7.8 GO:0019239 deaminase activity(GO:0019239)
0.8 7.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.8 2.3 GO:0015385 sodium:proton antiporter activity(GO:0015385)
0.8 6.0 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.8 1.5 GO:0016878 CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
0.7 2.0 GO:0015658 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.7 2.0 GO:0016642 glycine dehydrogenase (decarboxylating) activity(GO:0004375) oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor(GO:0016642)
0.6 6.5 GO:0031386 protein tag(GO:0031386)
0.6 9.7 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.6 3.0 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.6 11.9 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.6 1.7 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.6 2.3 GO:0016531 copper chaperone activity(GO:0016531)
0.6 11.6 GO:0008301 DNA binding, bending(GO:0008301)
0.5 7.4 GO:0015578 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.5 4.6 GO:0000293 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.5 2.0 GO:0004396 hexokinase activity(GO:0004396)
0.5 2.0 GO:0015603 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.5 1.5 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.5 21.0 GO:0001228 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.5 1.8 GO:0000156 phosphorelay response regulator activity(GO:0000156)
0.4 2.7 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.4 3.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.4 0.4 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.4 0.9 GO:0015116 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.4 1.3 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
0.4 2.6 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.4 1.2 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.4 1.2 GO:0008902 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.4 2.0 GO:0000400 four-way junction DNA binding(GO:0000400)
0.4 2.7 GO:0004364 glutathione transferase activity(GO:0004364)
0.4 1.8 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.4 1.4 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
0.3 3.8 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.3 1.0 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.3 7.8 GO:0008234 cysteine-type peptidase activity(GO:0008234)
0.3 1.0 GO:0004458 D-lactate dehydrogenase (cytochrome) activity(GO:0004458)
0.3 3.2 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.3 0.9 GO:0032183 SUMO binding(GO:0032183)
0.3 1.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.3 3.8 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.3 22.2 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.3 2.3 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.3 1.4 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.3 1.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.3 1.3 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.3 2.9 GO:0035064 methylated histone binding(GO:0035064)
0.3 2.1 GO:0031072 heat shock protein binding(GO:0031072)
0.3 0.8 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.3 0.8 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.3 0.5 GO:0015085 calcium ion transmembrane transporter activity(GO:0015085)
0.3 0.3 GO:0005057 receptor signaling protein activity(GO:0005057)
0.2 2.2 GO:0030983 mismatched DNA binding(GO:0030983)
0.2 3.4 GO:0004601 peroxidase activity(GO:0004601) oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)
0.2 0.7 GO:0042736 NAD+ kinase activity(GO:0003951) NADH kinase activity(GO:0042736)
0.2 0.7 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 3.3 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.2 5.5 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.2 0.6 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.2 0.8 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.2 14.9 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.2 0.4 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) solute:cation antiporter activity(GO:0015298) solute:proton antiporter activity(GO:0015299) potassium:proton antiporter activity(GO:0015386) cation:cation antiporter activity(GO:0015491) potassium ion antiporter activity(GO:0022821)
0.2 3.0 GO:0016831 carboxy-lyase activity(GO:0016831)
0.2 0.6 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.2 1.0 GO:0017022 myosin binding(GO:0017022)
0.2 1.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 20.0 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.2 0.3 GO:0015203 polyamine transmembrane transporter activity(GO:0015203)
0.2 3.2 GO:0031491 nucleosome binding(GO:0031491)
0.2 0.8 GO:0008236 serine-type peptidase activity(GO:0008236)
0.2 0.5 GO:0015293 symporter activity(GO:0015293)
0.2 1.0 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.2 0.3 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
0.1 1.5 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.1 0.4 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.1 0.4 GO:0045118 azole transporter activity(GO:0045118)
0.1 1.4 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.1 1.1 GO:0051184 cofactor transporter activity(GO:0051184)
0.1 0.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.1 1.2 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 0.2 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 0.7 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 0.5 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.1 0.8 GO:0019787 ubiquitin-like protein transferase activity(GO:0019787)
0.1 1.3 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 0.2 GO:0009378 four-way junction helicase activity(GO:0009378)
0.1 0.2 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.1 0.3 GO:0008897 holo-[acyl-carrier-protein] synthase activity(GO:0008897)
0.1 1.2 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.1 0.2 GO:0016504 peptidase activator activity(GO:0016504)
0.1 0.2 GO:0005034 osmosensor activity(GO:0005034)
0.1 0.4 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H3-K9 specific)(GO:0032129) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970) NAD-dependent histone deacetylase activity (H3-K18 specific)(GO:0097372)
0.1 0.3 GO:0043141 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.1 1.3 GO:0051087 chaperone binding(GO:0051087)
0.1 0.8 GO:0003712 transcription cofactor activity(GO:0003712)
0.1 0.1 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
0.1 9.8 GO:0008270 zinc ion binding(GO:0008270)
0.1 0.2 GO:0003954 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.2 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.1 0.2 GO:0005261 cation channel activity(GO:0005261)
0.1 0.5 GO:0005507 copper ion binding(GO:0005507)
0.1 0.4 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 0.2 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.5 GO:0045182 translation regulator activity(GO:0045182)
0.0 0.4 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.1 GO:0004100 chitin synthase activity(GO:0004100)
0.0 0.2 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.0 1.4 GO:0004175 endopeptidase activity(GO:0004175)
0.0 0.2 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.0 0.2 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.0 0.1 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.1 GO:0019776 Atg8 ligase activity(GO:0019776)
0.0 0.1 GO:0033613 RNA polymerase II activating transcription factor binding(GO:0001102) activating transcription factor binding(GO:0033613)
0.0 0.3 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 0.3 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.2 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.0 0.1 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.1 GO:0015297 antiporter activity(GO:0015297)
0.0 0.1 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.0 0.1 GO:0016279 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.0 0.0 GO:0016882 cyclo-ligase activity(GO:0016882)
0.0 0.3 GO:0008374 O-acyltransferase activity(GO:0008374)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 3.1 PID IL4 2PATHWAY IL4-mediated signaling events
1.4 5.7 PID ERBB4 PATHWAY ErbB4 signaling events
0.9 2.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.9 2.8 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.4 2.3 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.4 3.2 PID FANCONI PATHWAY Fanconi anemia pathway
0.2 0.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 0.2 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 221.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.1 0.4 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.1 0.4 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 0.2 PID CMYB PATHWAY C-MYB transcription factor network
0.1 0.2 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 0.2 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.1 0.2 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.7 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.8 1.6 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.7 8.1 REACTOME DNA REPAIR Genes involved in DNA Repair
0.6 1.9 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.3 1.4 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.3 2.2 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.3 2.7 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.2 1.3 REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES Genes involved in Transmembrane transport of small molecules
0.2 1.8 REACTOME RNA POL II PRE TRANSCRIPTION EVENTS Genes involved in RNA Polymerase II Pre-transcription Events
0.2 2.6 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 0.2 REACTOME SIGNALING BY NOTCH1 Genes involved in Signaling by NOTCH1
0.1 221.1 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 0.6 REACTOME INNATE IMMUNE SYSTEM Genes involved in Innate Immune System
0.1 0.7 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 0.2 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.2 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.1 REACTOME RNA POL II TRANSCRIPTION Genes involved in RNA Polymerase II Transcription