Results for GAT1
Z-value: 1.55
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Transcription factors associated with GAT1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
GAT1
|
S000001873 | Transcriptional activator of genes involved in NCR |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YDL210W Show fit | 29.36 |
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane |
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| YBL049W Show fit | 25.01 |
Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase |
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| YAL062W Show fit | 19.50 |
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources |
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| YNL144C Show fit | 19.10 |
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene |
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| YPL054W Show fit | 18.81 |
Zinc-finger protein of unknown function |
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| YOR348C Show fit | 16.65 |
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells |
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| YMR107W Show fit | 16.15 |
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources |
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| YNL142W Show fit | 15.24 |
Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation |
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| YLR307C-A Show fit | 14.29 |
Putative protein of unknown function |
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| YER065C Show fit | 14.25 |
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose |
Network of associatons between targets according to the STRING database.
First level regulatory network of GAT1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.3 | 33.1 | GO:0015847 | putrescine transport(GO:0015847) |
| 3.9 | 27.5 | GO:0000256 | allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256) |
| 7.5 | 22.5 | GO:0072488 | ammonium transmembrane transport(GO:0072488) |
| 2.8 | 22.3 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 2.9 | 17.6 | GO:0000501 | flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501) |
| 4.1 | 16.6 | GO:0015804 | neutral amino acid transport(GO:0015804) |
| 5.4 | 16.2 | GO:0090295 | nitrogen catabolite repression of transcription(GO:0090295) |
| 0.3 | 13.2 | GO:0009060 | aerobic respiration(GO:0009060) |
| 3.1 | 12.4 | GO:0000949 | aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949) |
| 4.0 | 12.1 | GO:0006562 | proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 29.6 | GO:0000329 | fungal-type vacuole membrane(GO:0000329) lytic vacuole membrane(GO:0098852) |
| 0.1 | 22.2 | GO:0005886 | plasma membrane(GO:0005886) |
| 1.3 | 11.7 | GO:0045275 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.6 | 8.4 | GO:0005619 | ascospore wall(GO:0005619) |
| 1.9 | 7.6 | GO:0000148 | 1,3-beta-D-glucan synthase complex(GO:0000148) |
| 0.1 | 7.1 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 2.3 | 6.8 | GO:0009353 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252) |
| 2.1 | 6.3 | GO:0032585 | multivesicular body membrane(GO:0032585) |
| 2.0 | 5.9 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
| 1.4 | 5.7 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.1 | 33.4 | GO:0015489 | putrescine transmembrane transporter activity(GO:0015489) |
| 6.5 | 26.1 | GO:0015193 | L-proline transmembrane transporter activity(GO:0015193) |
| 0.3 | 22.2 | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981) |
| 0.5 | 21.0 | GO:0001228 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.2 | 20.0 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 1.5 | 19.5 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 4.6 | 18.3 | GO:0005537 | mannose binding(GO:0005537) |
| 1.5 | 16.7 | GO:0008519 | ammonium transmembrane transporter activity(GO:0008519) |
| 0.2 | 14.9 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 2.3 | 14.0 | GO:0016888 | endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 221.1 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 1.4 | 5.7 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.4 | 3.2 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 1.6 | 3.1 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.9 | 2.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.9 | 2.8 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.4 | 2.3 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.2 | 0.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 0.4 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.1 | 0.4 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 221.1 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.7 | 8.1 | REACTOME DNA REPAIR | Genes involved in DNA Repair |
| 1.9 | 5.7 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.3 | 2.7 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.2 | 2.6 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.3 | 2.2 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.6 | 1.9 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.2 | 1.8 | REACTOME RNA POL II PRE TRANSCRIPTION EVENTS | Genes involved in RNA Polymerase II Pre-transcription Events |
| 0.8 | 1.6 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.3 | 1.4 | REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE | Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle |