Navigation
Downloads

Results for GAL4

Z-value: 1.44

Motif logo

logo of

Transcription factors associated with GAL4

Gene Symbol Gene ID Gene Info
GAL4
S000006169 DNA-binding transcription factor required for activating GAL genes

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GAL4YPL248C0.791.5e-06Click!

Activity profile of GAL4 motif

Sorted Z-values of GAL4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YJL045W 15.21 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YJR048W 7.07
CYC1
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YOL052C-A 6.92
DDR2
Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses
YBR019C 6.74
GAL10
UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers
YOR348C 6.46
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YNL117W 6.30
MLS1
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YGR067C 6.11 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YLR312C 6.11
QNQ1
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YMR105C 5.81
PGM2
Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase
YGR183C 5.60
QCR9
Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
YLR122C 5.24 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YEL039C 4.98
CYC7
Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YMR206W 4.73 Putative protein of unknown function; YMR206W is not an essential gene
YDR342C 4.69
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YDR277C 4.68
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YPR036W-A 4.61 Protein of unknown function; transcription is regulated by Pdr1p
YOR120W 4.59
GCY1
Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family
YBR020W 4.54
GAL1
Galactokinase, phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p
YBR222C 4.44
PCS60
Peroxisomal AMP-binding protein, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase
YBR018C 4.30
GAL7
Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism
YLR123C 4.29 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YLR038C 4.19
COX12
Subunit VIb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated
YPR023C 4.01
EAF3
Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition
YKL217W 3.96
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YKL103C 3.83
LAP4
Vacuolar aminopeptidase, often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway
YCL057C-A 3.82 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR343C 3.69
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YER103W 3.51
SSA4
Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation
YNL074C 3.40
MLF3
Serine-rich protein of unknown function; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
YKR097W 3.37
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YOR139C 3.35 Hypothetical protein
YOL051W 3.32
GAL11
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors
YLR377C 3.29
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YJL217W 3.24 Cytoplasmic protein of unknown function; expression induced by calcium shortage and via the copper sensing transciption factor Mac1p during conditons of copper deficiency; mRNA is cell cycle regulated, peaking in G1 phase
YER039C-A 3.23 Putative protein of unknown function; YER039C-A is not an essential gene
YMR103C 3.21 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJR146W 3.19 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2
YNL190W 3.17 Cell wall protein of unknown function; proposed role as a hydrophilin induced by osmotic stress; contains a putative GPI-attachment site
YER158C 3.06 Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p
YOR140W 2.99
SFL1
Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p
YKL148C 2.97
SDH1
Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YLR327C 2.94
TMA10
Protein of unknown function that associates with ribosomes
YLR125W 2.91 Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene
YNL240C 2.90
NAR1
Nuclear architecture related protein; component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins; homologous to human Narf
YLR174W 2.90
IDP2
Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
YLR152C 2.88 Putative protein of unknown function; YLR152C is not an essential gene
YPL230W 2.84
USV1
Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in protein folding, ATP binding, and cell wall biosynthesis
YJR095W 2.83
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YLR124W 2.74 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKR067W 2.72
GPT2
Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis
YMR056C 2.70
AAC1
Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator
YDR009W 2.67
GAL3
Transcriptional regulator involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity
YLR111W 2.63 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL102C 2.62 Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
YHR139C 2.56
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YFR033C 2.46
QCR6
Subunit 6 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1
YDL010W 2.39
GRX6
Cis-golgi localized monothiol glutaredoxin that binds an iron-sulfur cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; functional overlap with GRX6
YER101C 2.36
AST2
Protein that may have a role in targeting of plasma membrane [H+]ATPase (Pma1p) to the plasma membrane, as suggested by analysis of genetic interactions
YKL093W 2.35
MBR1
Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants
YDL011C 2.33 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W
YEL020C 2.31 Hypothetical protein with low sequence identity to Pdc1p
YKR066C 2.29
CCP1
Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress
YPR065W 2.28
ROX1
Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity
YBL045C 2.28
COR1
Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain
YJL156W-A 2.28 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR402W 2.24 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL144C 2.23 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YLR047C 2.23
FRE8
Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p
YOR065W 2.22
CYT1
Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
YLR403W 2.20
SFP1
Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
YAR023C 2.19 Putative integral membrane protein, member of DUP240 gene family
YLR281C 2.17 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene
YLR304C 2.17
ACO1
Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy
YDL138W 2.14
RGT2
Plasma membrane glucose receptor, highly similar to Snf3p; both Rgt2p and Snf3p serve as transmembrane glucose sensors generating an intracellular signal that induces expression of glucose transporter (HXT) genes
YLR280C 2.13 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YML051W 2.12
GAL80
Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding
YNL055C 2.11
POR1
Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated
YLR240W 2.04
VPS34
Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p
YHR086W 2.04
NAM8
RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of MER2 pre-mRNA
YOR374W 2.02
ALD4
Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
YOR138C 1.96
RUP1
Protein involved in regulation of Rsp5p, which is an essential HECT ubiquitin ligase; required for binding of Rsp5p to Ubp2p; contains an UBA domain
YPR027C 1.94 Putative protein of unknown function
YBR033W 1.92
EDS1
Putative zinc cluster protein; YBR033W is not an essential gene
YHL040C 1.90
ARN1
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores
YLR252W 1.90 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SYM1, a mitochondrial protein involved in ethanol metabolism
YDR259C 1.90
YAP6
Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance
YBL100C 1.86 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the 5' end of ATP1
YLL029W 1.86
FRA1
Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation
YGL134W 1.85
PCL10
Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate
YPR196W 1.85 Putative maltose activator
YFR015C 1.83
GSY1
Glycogen synthase with similarity to Gsy2p, the more highly expressed yeast homolog; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase
YDL012C 1.78 Plasma membrane protein of unknown function; YDL012C is not an essential gene
YBL099W 1.71
ATP1
Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YPL135W 1.70
ISU1
Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable
YLR202C 1.70 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
YKL129C 1.69
MYO3
One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
YPR061C 1.68
JID1
Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
YOL131W 1.66 Putative protein of unknown function
YHR092C 1.66
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YMR250W 1.62
GAD1
Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress
YLR334C 1.60 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here
YHR211W 1.60
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YLR201C 1.60
COQ9
Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
YDL222C 1.60
FMP45
Integral membrane protein localized to mitochondria (untagged protein) and eisosomes, immobile patches at the cortex associated with endocytosis; sporulation and sphingolipid content are altered in mutants; has homologs SUR7 and YNL194C
YDR096W 1.59
GIS1
JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1
YHR015W 1.58
MIP6
Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export
YOL052C 1.56
SPE2
S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically
YPR024W 1.54
YME1
Subunit, with Mgr1p, of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; mutation causes an elevated rate of mitochondrial turnover
YOR346W 1.51
REV1
Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YDR347W 1.50
MRP1
Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein
YNL196C 1.48
SLZ1
Sporulation-specific protein with a leucine zipper motif
YER150W 1.48
SPI1
GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YDR379C-A 1.48 Hypothetical protein identified by homology. See FEBS Letters [2000] 487:31-36.
YJR147W 1.44
HMS2
Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
YNL328C 1.44
MDJ2
Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain
YNL142W 1.42
MEP2
Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YNR063W 1.42 Putative zinc-cluster protein of unknown function
YOR345C 1.41 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YLL049W 1.40
LDB18
Protein of unknown function; null mutant shows a reduced affinity for the alcian blue dye suggesting a decreased net negative charge of the cell surface
YOL110W 1.40
SHR5
Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization
YOR378W 1.36 Putative protein of unknown function; belongs to the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
YKL146W 1.33
AVT3
Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YKL147C 1.32 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3
YPR192W 1.30
AQY1
Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance
YDR090C 1.26 Putative protein of unknown function
YPR064W 1.22 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YHR008C 1.16
SOD2
Mitochondrial superoxide dismutase, protects cells against oxygen toxicity; phosphorylated
YIR027C 1.13
DAL1
Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression
YOL100W 1.10
PKH2
Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p
YBL015W 1.09
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YDR536W 1.08
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YER091C-A 1.07 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YER088C 1.06
DOT6
Protein of unknown function, involved in telomeric gene silencing and filamentation
YGL180W 1.06
ATG1
Protein serine/threonine kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for pre-autophagosome formation; during autophagy forms a complex with Atg13p and Atg17p
YDR216W 1.06
ADR1
Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
YOR388C 1.05
FDH1
NAD(+)-dependent formate dehydrogenase, may protect cells from exogenous formate
YGL081W 1.04 Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
YNL241C 1.03
ZWF1
Glucose-6-phosphate dehydrogenase (G6PD), catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia
YOR049C 1.01
RSB1
Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
YPL156C 1.01
PRM4
Pheromone-regulated protein, predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift
YGL188C 0.98 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YEL012W 0.97
UBC8
Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
YPR117W 0.97 Putative protein of unknown function
YFL024C 0.96
EPL1
Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb
YHR217C 0.95 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; located in the telomeric region TEL08R.
YDL139C 0.95
SCM3
Nonhistone component of centromeric chromatin that binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; contains nuclear export signal (NES); required for G2/M progression and localization of Cse4p
YJR004C 0.91
SAG1
Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor
YIL162W 0.91
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YLR121C 0.90
YPS3
Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YPL067C 0.87 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene
YFL021W 0.87
GAT1
Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p
YLR055C 0.86
SPT8
Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
YHR050W 0.85
SMF2
Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins
YGL053W 0.85
PRM8
Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family
YFL011W 0.85
HXT10
Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YOR072W 0.85 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YDL182W 0.84
LYS20
Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys21p
YPR013C 0.82 Putative zinc finger protein; YPR013C is not an essential gene
YLR164W 0.82 Mitochondrial inner membrane of unknown function; similar to Tim18p and Sdh4p; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YFR053C 0.82
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YKL065W-A 0.82 Putative protein of unknown function
YMR057C 0.81 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1
YMR194C-B 0.81 Putative protein of unknown function
YPL154C 0.80
PEP4
Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; synthesized as a zymogen, self-activates
YBL033C 0.79
RIB1
GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway
YIL065C 0.79
FIS1
Mitochondrial outer membrane protein involved in membrane fission, required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation
YDL140C 0.76
RPO21
RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
YOR071C 0.75
NRT1
High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
YNL092W 0.75 Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene
YBR201C-A 0.74 Putative protein of unknown function
YNL239W 0.74
LAP3
Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH
YBR051W 0.73 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase
YPR028W 0.72
YOP1
Membrane protein that interacts with Yip1p to mediate membrane traffic; overexpression results in cell death and accumulation of internal cell membranes; regulates vesicular traffic in stressed cells
YDR058C 0.71
TGL2
Protein with lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli; role in yeast lipid degradation is unclear
YNL143C 0.71 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR050C 0.70
REG2
Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
YNL180C 0.69
RHO5
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
YGR087C 0.69
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YNL160W 0.67
YGP1
Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p
YOR072W-A 0.67 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR072W; originally identified by fungal homology and RT-PCR
YAR027W 0.66
UIP3
Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family
YGR286C 0.65
BIO2
Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant
YOR389W 0.64 Putative protein of unknown function; expression regulated by copper levels
YNL179C 0.63 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
YHR082C 0.63
KSP1
Nonessential putative serine/threonine protein kinase of unknown cellular role; overproduction causes allele-specific suppression of the prp20-10 mutation
YHR218W 0.63 Helicase-like protein encoded within the telomeric Y' element
YDL113C 0.63
ATG20
Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate
YGL096W 0.61
TOS8
Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p
YDR380W 0.60
ARO10
Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway
YJL116C 0.59
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YGL165C 0.58 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W
YDL246C 0.57
SOR2
Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in fructose or mannose metabolism
YHL024W 0.57
RIM4
Putative RNA-binding protein required for the expression of early and middle sporulation genes
YHR176W 0.56
FMO1
Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins
YMR017W 0.56
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YMR275C 0.55
BUL1
Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex, functional homolog of Bul2p, disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases
YOL081W 0.55
IRA2
GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin
YOL154W 0.55
ZPS1
Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
YCL057W 0.55
PRD1
Zinc metalloendopeptidase, found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins
YOR064C 0.55
YNG1
Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3, has similarity to the human tumor suppressor ING1

Network of associatons between targets according to the STRING database.

First level regulatory network of GAL4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 15.6 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
2.3 4.6 GO:0042843 D-xylose catabolic process(GO:0042843)
2.2 22.3 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
1.9 5.8 GO:0019388 galactose catabolic process(GO:0019388)
1.6 6.5 GO:0015804 neutral amino acid transport(GO:0015804)
1.0 3.1 GO:0006740 NADPH regeneration(GO:0006740)
1.0 9.1 GO:0006097 glyoxylate cycle(GO:0006097)
1.0 4.0 GO:0009300 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
1.0 3.0 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
1.0 4.0 GO:0006848 pyruvate transport(GO:0006848)
0.9 2.8 GO:0015740 C4-dicarboxylate transport(GO:0015740)
0.9 2.8 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.8 3.9 GO:0006012 galactose metabolic process(GO:0006012)
0.7 2.2 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.7 2.1 GO:0051594 detection of chemical stimulus(GO:0009593) detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) detection of stimulus(GO:0051606)
0.7 2.0 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.7 2.0 GO:0050685 regulation of RNA splicing(GO:0043484) regulation of mRNA splicing, via spliceosome(GO:0048024) positive regulation of mRNA processing(GO:0050685)
0.7 2.7 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.7 2.7 GO:0015886 heme transport(GO:0015886)
0.7 14.1 GO:0015749 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.6 1.9 GO:0071281 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.6 3.0 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.5 1.6 GO:0006538 glutamate catabolic process(GO:0006538)
0.5 1.1 GO:0034310 ethanol catabolic process(GO:0006068) primary alcohol catabolic process(GO:0034310)
0.5 1.6 GO:0008216 spermidine metabolic process(GO:0008216)
0.5 2.5 GO:0061416 regulation of transcription from RNA polymerase II promoter in response to salt stress(GO:0061416)
0.5 1.4 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.4 6.0 GO:0072593 reactive oxygen species metabolic process(GO:0072593)
0.4 2.1 GO:0044070 regulation of anion transport(GO:0044070)
0.4 2.4 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.4 1.6 GO:0016577 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.4 3.5 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.4 1.8 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.3 4.2 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.3 1.3 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
0.3 0.9 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.3 0.9 GO:0006824 cobalt ion transport(GO:0006824)
0.3 1.1 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
0.3 1.1 GO:0006083 acetate metabolic process(GO:0006083)
0.3 1.6 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.3 1.3 GO:0034487 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.3 0.8 GO:0015888 thiamine transport(GO:0015888)
0.2 1.3 GO:0000255 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256)
0.2 1.1 GO:0015793 glycerol transport(GO:0015793)
0.2 1.7 GO:0015891 siderophore transport(GO:0015891)
0.2 1.1 GO:0090294 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
0.2 0.6 GO:0030802 regulation of cyclic nucleotide metabolic process(GO:0030799) regulation of cyclic nucleotide biosynthetic process(GO:0030802) regulation of nucleotide biosynthetic process(GO:0030808) regulation of cAMP metabolic process(GO:0030814) regulation of cAMP biosynthetic process(GO:0030817) regulation of purine nucleotide biosynthetic process(GO:1900371)
0.2 8.5 GO:0009060 aerobic respiration(GO:0009060)
0.2 1.4 GO:0018345 protein palmitoylation(GO:0018345)
0.2 2.7 GO:0006754 ATP biosynthetic process(GO:0006754)
0.2 1.5 GO:0070987 error-free translesion synthesis(GO:0070987)
0.2 0.6 GO:0006768 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.2 4.3 GO:0006094 gluconeogenesis(GO:0006094)
0.2 1.0 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.2 0.6 GO:0032108 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.2 0.5 GO:0009107 lipoate metabolic process(GO:0009106) lipoate biosynthetic process(GO:0009107)
0.1 0.7 GO:0046461 triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)
0.1 1.8 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.1 0.4 GO:0006546 glycine catabolic process(GO:0006546)
0.1 0.9 GO:0000266 mitochondrial fission(GO:0000266)
0.1 1.0 GO:0045332 phospholipid translocation(GO:0045332)
0.1 0.7 GO:0050667 homocysteine metabolic process(GO:0050667)
0.1 1.7 GO:0051666 actin cortical patch localization(GO:0051666)
0.1 0.7 GO:0051292 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.1 0.5 GO:0032077 positive regulation of deoxyribonuclease activity(GO:0032077) positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.1 1.4 GO:0040001 establishment of mitotic spindle orientation(GO:0000132) establishment of mitotic spindle localization(GO:0040001) establishment of spindle orientation(GO:0051294)
0.1 2.1 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 0.9 GO:0005987 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.1 2.2 GO:0016579 protein deubiquitination(GO:0016579)
0.1 1.5 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.1 0.6 GO:0006279 premeiotic DNA replication(GO:0006279)
0.1 0.5 GO:0001041 transcription from RNA polymerase III type 2 promoter(GO:0001009) transcription from a RNA polymerase III hybrid type promoter(GO:0001041)
0.1 0.8 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.1 1.6 GO:0001101 response to acid chemical(GO:0001101)
0.1 3.2 GO:0070726 cell wall assembly(GO:0070726)
0.1 0.5 GO:0046686 response to cadmium ion(GO:0046686)
0.1 3.0 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.1 1.7 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.1 0.5 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.1 0.5 GO:0046685 negative regulation of transcription by pheromones(GO:0045996) negative regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046020) response to arsenic-containing substance(GO:0046685)
0.1 0.1 GO:0019627 urea metabolic process(GO:0019627)
0.1 1.0 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.1 0.2 GO:0015809 arginine transport(GO:0015809)
0.1 0.3 GO:0008053 mitochondrial fusion(GO:0008053)
0.1 1.8 GO:0006612 protein targeting to membrane(GO:0006612)
0.0 0.2 GO:0032373 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.0 0.2 GO:0000709 meiotic joint molecule formation(GO:0000709)
0.0 0.2 GO:0031507 heterochromatin assembly(GO:0031507)
0.0 1.4 GO:0022900 electron transport chain(GO:0022900)
0.0 0.2 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.0 0.4 GO:0030100 regulation of endocytosis(GO:0030100)
0.0 0.0 GO:0045981 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.0 0.2 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.0 1.1 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.0 0.5 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 0.8 GO:0019318 hexose metabolic process(GO:0019318)
0.0 0.1 GO:0051031 tRNA transport(GO:0051031)
0.0 0.7 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.8 GO:0010324 membrane invagination(GO:0010324) lysosomal microautophagy(GO:0016237) single-organism membrane invagination(GO:1902534)
0.0 1.7 GO:0071427 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0 0.1 GO:0006545 glycine biosynthetic process(GO:0006545) threonine catabolic process(GO:0006567)
0.0 0.7 GO:0007266 Rho protein signal transduction(GO:0007266)
0.0 0.5 GO:0000209 protein polyubiquitination(GO:0000209)
0.0 0.2 GO:0006078 (1->6)-beta-D-glucan biosynthetic process(GO:0006078)
0.0 0.4 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.0 0.2 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.0 0.2 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.0 0.2 GO:0008615 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.0 0.0 GO:0043901 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.0 0.2 GO:0031333 negative regulation of protein complex assembly(GO:0031333)
0.0 0.1 GO:0060237 regulation of fungal-type cell wall organization(GO:0060237)
0.0 0.0 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 0.2 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.4 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) ERAD pathway(GO:0036503)
0.0 0.1 GO:0051181 cofactor transport(GO:0051181)
0.0 0.3 GO:0006200 obsolete ATP catabolic process(GO:0006200)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 12.6 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
1.1 19.2 GO:0070469 respiratory chain(GO:0070469)
0.9 10.9 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.8 2.4 GO:0005796 Golgi lumen(GO:0005796)
0.8 3.8 GO:0032221 Rpd3S complex(GO:0032221)
0.7 2.1 GO:0046930 pore complex(GO:0046930)
0.7 2.0 GO:0071561 nucleus-vacuole junction(GO:0071561)
0.4 1.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.3 1.7 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.3 1.4 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.3 0.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.3 1.4 GO:0005869 dynactin complex(GO:0005869)
0.2 1.7 GO:0016459 myosin complex(GO:0016459)
0.2 1.4 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.2 1.1 GO:0032126 eisosome(GO:0032126)
0.2 4.2 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.2 3.3 GO:0070847 core mediator complex(GO:0070847)
0.2 1.3 GO:0042597 periplasmic space(GO:0042597)
0.2 1.0 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 0.4 GO:0005960 glycine cleavage complex(GO:0005960)
0.1 0.6 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 0.5 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 2.0 GO:0005685 U1 snRNP(GO:0005685)
0.1 0.5 GO:0070775 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.1 0.4 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) nucleoplasmic THO complex(GO:0000446)
0.1 0.1 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.1 1.0 GO:0033698 Rpd3L complex(GO:0033698)
0.1 0.8 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.1 0.5 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.1 1.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 2.0 GO:0098800 inner mitochondrial membrane protein complex(GO:0098800)
0.1 0.7 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.1 0.3 GO:0000813 ESCRT I complex(GO:0000813)
0.1 0.8 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 0.2 GO:0030122 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128) endocytic vesicle(GO:0030139) endocytic vesicle membrane(GO:0030666) clathrin-coated endocytic vesicle membrane(GO:0030669) clathrin-coated endocytic vesicle(GO:0045334)
0.1 2.5 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 1.5 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.2 GO:0032545 CURI complex(GO:0032545)
0.0 0.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 5.3 GO:0000324 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.0 13.6 GO:0005886 plasma membrane(GO:0005886)
0.0 0.2 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.0 6.2 GO:0031966 mitochondrial membrane(GO:0031966)
0.0 0.6 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.1 GO:0072379 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.0 1.3 GO:0005657 replication fork(GO:0005657)
0.0 0.2 GO:0016272 prefoldin complex(GO:0016272)
0.0 1.3 GO:0000779 condensed chromosome, centromeric region(GO:0000779)
0.0 0.9 GO:0005774 vacuolar membrane(GO:0005774)
0.0 0.6 GO:0030479 actin cortical patch(GO:0030479) endocytic patch(GO:0061645)
0.0 0.2 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.2 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.1 GO:0005619 ascospore wall(GO:0005619)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.4 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
1.5 4.4 GO:0016208 AMP binding(GO:0016208)
1.5 5.8 GO:0004614 phosphoglucomutase activity(GO:0004614)
1.4 4.3 GO:0070569 uridylyltransferase activity(GO:0070569)
1.3 10.3 GO:0016679 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
1.1 4.6 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
1.0 4.1 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
1.0 5.0 GO:0015295 solute:proton symporter activity(GO:0015295)
1.0 16.6 GO:0046906 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
1.0 2.9 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
1.0 3.8 GO:0016854 racemase and epimerase activity(GO:0016854)
0.8 3.3 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
0.7 2.1 GO:0005536 glucose binding(GO:0005536)
0.7 2.8 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.7 2.1 GO:0015288 anion channel activity(GO:0005253) voltage-gated anion channel activity(GO:0008308) porin activity(GO:0015288) wide pore channel activity(GO:0022829)
0.7 2.7 GO:0005347 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
0.7 3.3 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.6 7.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.6 3.0 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.6 2.4 GO:0004362 glutathione-disulfide reductase activity(GO:0004362)
0.5 1.6 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.5 1.9 GO:0015343 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.5 4.6 GO:0005353 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.4 2.7 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.4 1.3 GO:0015188 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.4 4.2 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.4 2.0 GO:0052742 phosphatidylinositol kinase activity(GO:0052742)
0.4 1.6 GO:0005537 mannose binding(GO:0005537)
0.4 7.8 GO:0016831 carboxy-lyase activity(GO:0016831)
0.4 1.1 GO:0016289 CoA hydrolase activity(GO:0016289)
0.3 3.8 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.3 1.7 GO:0008198 ferrous iron binding(GO:0008198)
0.3 1.7 GO:0000146 microfilament motor activity(GO:0000146)
0.3 2.0 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.3 1.3 GO:0001091 RNA polymerase II basal transcription factor binding(GO:0001091)
0.3 0.9 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.3 0.9 GO:0004575 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
0.3 4.9 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.2 2.2 GO:0000293 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.2 2.7 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.2 1.1 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.2 4.1 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.2 2.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.2 2.3 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.2 1.9 GO:0004177 aminopeptidase activity(GO:0004177)
0.1 0.7 GO:0004806 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.1 1.8 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 0.6 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 1.0 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 1.6 GO:0050661 NADP binding(GO:0050661)
0.1 0.7 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 0.8 GO:0019238 cyclohydrolase activity(GO:0019238)
0.1 1.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 0.9 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 0.8 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.1 0.9 GO:0022838 substrate-specific channel activity(GO:0022838)
0.1 0.4 GO:0004375 glycine dehydrogenase (decarboxylating) activity(GO:0004375) oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor(GO:0016642)
0.1 1.4 GO:0001671 ATPase activator activity(GO:0001671)
0.1 1.0 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.1 2.2 GO:0004402 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.1 3.2 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.1 0.8 GO:0001055 RNA polymerase II activity(GO:0001055)
0.1 1.8 GO:0019901 protein kinase binding(GO:0019901)
0.1 0.2 GO:0016841 ammonia-lyase activity(GO:0016841)
0.1 0.6 GO:0008237 metallopeptidase activity(GO:0008237)
0.1 0.2 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.1 0.8 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 0.5 GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism(GO:0015662)
0.1 0.8 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 0.1 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.0 0.2 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.9 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.3 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 2.9 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.3 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.2 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.9 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.2 GO:0015294 solute:cation symporter activity(GO:0015294)
0.0 0.2 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.2 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.0 0.1 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 0.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.6 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.6 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.2 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.1 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 0.3 GO:0016298 lipase activity(GO:0016298)
0.0 1.9 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 0.2 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.1 GO:1901505 carbohydrate derivative transporter activity(GO:1901505)
0.0 0.3 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 0.4 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.1 GO:0010181 FMN binding(GO:0010181)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.5 1.5 PID IL4 2PATHWAY IL4-mediated signaling events
0.4 1.2 PID FOXO PATHWAY FoxO family signaling
0.0 66.6 PID RAS PATHWAY Regulation of Ras family activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 7.1 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
1.1 12.5 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.3 2.4 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 1.5 REACTOME DNA REPAIR Genes involved in DNA Repair
0.1 0.1 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 66.6 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.2 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination