Results for FKH2
Z-value: 1.07
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Transcription factors associated with FKH2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
FKH2
|
S000005012 | Forkhead family transcription factor |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YOR315W Show fit | 11.01 |
Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate |
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| YPR119W Show fit | 8.54 |
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome |
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| YGR108W Show fit | 7.23 |
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome |
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| YOR313C Show fit | 7.17 |
Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage |
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| YOR314W Show fit | 5.61 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
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| YJR094W-A Show fit | 4.05 |
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein |
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| YOL127W Show fit | 3.94 |
Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 26S rRNA via a conserved C-terminal motif |
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| YDR418W Show fit | 3.91 |
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins |
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| YIR021W Show fit | 3.82 |
Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA |
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| YGL021W Show fit | 3.48 |
Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk2p and to mammalian haspins |
Network of associatons between targets according to the STRING database.
First level regulatory network of FKH2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 32.6 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 2.3 | 16.3 | GO:0010696 | positive regulation of spindle pole body separation(GO:0010696) |
| 0.3 | 10.6 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 0.2 | 9.3 | GO:0007124 | pseudohyphal growth(GO:0007124) |
| 0.4 | 7.4 | GO:0030472 | mitotic spindle organization in nucleus(GO:0030472) |
| 0.3 | 6.6 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 1.5 | 6.0 | GO:0000092 | mitotic anaphase B(GO:0000092) |
| 0.3 | 6.0 | GO:0006450 | regulation of translational fidelity(GO:0006450) |
| 0.4 | 5.3 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 1.0 | 5.1 | GO:0045597 | positive regulation of cell fate commitment(GO:0010455) positive regulation of mating type switching(GO:0031496) positive regulation of cell differentiation(GO:0045597) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 34.2 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.3 | 25.6 | GO:0005819 | spindle(GO:0005819) |
| 0.4 | 21.7 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 1.2 | 7.4 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.1 | 7.1 | GO:0005935 | cellular bud neck(GO:0005935) |
| 0.7 | 6.1 | GO:0000144 | cellular bud neck septin ring(GO:0000144) |
| 0.1 | 5.8 | GO:0000131 | incipient cellular bud site(GO:0000131) |
| 0.7 | 5.7 | GO:0051233 | spindle midzone(GO:0051233) |
| 0.5 | 5.5 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.5 | 5.4 | GO:0000142 | cellular bud neck contractile ring(GO:0000142) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 36.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.7 | 18.0 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.1 | 14.4 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.3 | 12.1 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.2 | 8.2 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.2 | 6.9 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.8 | 5.6 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 1.1 | 5.5 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.2 | 5.5 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.2 | 4.9 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 2.8 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.2 | 2.0 | NABA MATRISOME | Ensemble of genes encoding extracellular matrix and extracellular matrix-associated proteins |
| 0.2 | 1.5 | PID ATR PATHWAY | ATR signaling pathway |
| 0.3 | 1.2 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.4 | 1.1 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.3 | 0.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 0.7 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 0.5 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.2 | 0.4 | PID FOXO PATHWAY | FoxO family signaling |
| 0.1 | 0.4 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 12.6 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 0.4 | 4.7 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.4 | 2.9 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.5 | 1.4 | REACTOME SIGNALLING TO ERKS | Genes involved in Signalling to ERKs |
| 0.2 | 1.4 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.4 | 1.2 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.1 | 1.2 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.3 | 0.6 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.1 | 0.6 | REACTOME DNA STRAND ELONGATION | Genes involved in DNA strand elongation |
| 0.1 | 0.6 | REACTOME TRANSLATION | Genes involved in Translation |