Results for FKH1
Z-value: 1.18
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Transcription factors associated with FKH1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
FKH1
|
S000001393 | Forkhead family transcription factor |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YOR315W Show fit | 29.72 |
Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate |
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| YGR108W Show fit | 28.34 |
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome |
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| YPR119W Show fit | 25.72 |
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome |
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| YER124C Show fit | 14.53 |
Daughter cell-specific protein, may participate in pathways regulating cell wall metabolism; deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall |
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| YDR033W Show fit | 13.31 |
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p |
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| YOR314W Show fit | 12.60 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
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| YOR313C Show fit | 11.91 |
Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage |
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| YIR021W Show fit | 11.69 |
Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA |
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| YKL096W-A Show fit | 11.68 |
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored |
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| YJR094W-A Show fit | 11.33 |
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein |
Network of associatons between targets according to the STRING database.
First level regulatory network of FKH1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 108.4 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 7.9 | 55.1 | GO:0010696 | positive regulation of spindle pole body separation(GO:0010696) |
| 3.1 | 34.1 | GO:0007109 | obsolete cytokinesis, completion of separation(GO:0007109) |
| 0.6 | 31.9 | GO:0007124 | pseudohyphal growth(GO:0007124) |
| 0.8 | 19.7 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.9 | 18.1 | GO:0006450 | regulation of translational fidelity(GO:0006450) |
| 0.6 | 14.1 | GO:0006885 | regulation of pH(GO:0006885) |
| 0.9 | 13.2 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 1.5 | 11.8 | GO:0000372 | Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376) |
| 2.2 | 10.8 | GO:0060277 | obsolete negative regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0060277) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 82.2 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 1.0 | 60.0 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.3 | 42.9 | GO:0005933 | cellular bud(GO:0005933) |
| 0.5 | 36.1 | GO:0009277 | fungal-type cell wall(GO:0009277) |
| 0.4 | 28.8 | GO:0000922 | spindle pole(GO:0000922) |
| 1.5 | 25.3 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 1.5 | 18.2 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 1.7 | 15.4 | GO:0000144 | cellular bud neck septin ring(GO:0000144) |
| 0.4 | 12.9 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 0.3 | 12.6 | GO:0030686 | 90S preribosome(GO:0030686) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 97.0 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 2.3 | 58.7 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.7 | 30.7 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.7 | 19.2 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 1.2 | 14.6 | GO:0005199 | structural constituent of cell wall(GO:0005199) |
| 0.2 | 11.8 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.7 | 11.7 | GO:0001056 | RNA polymerase III activity(GO:0001056) |
| 1.6 | 11.2 | GO:0008422 | beta-glucosidase activity(GO:0008422) |
| 0.7 | 10.4 | GO:0015926 | glucosidase activity(GO:0015926) |
| 1.0 | 10.3 | GO:0005216 | ion channel activity(GO:0005216) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 3.7 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.9 | 2.6 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.7 | 2.6 | PID E2F PATHWAY | E2F transcription factor network |
| 0.7 | 2.2 | PID SHP2 PATHWAY | SHP2 signaling |
| 1.0 | 2.0 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.2 | 2.0 | PID ATR PATHWAY | ATR signaling pathway |
| 0.5 | 1.6 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.3 | 1.4 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.4 | 1.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 1.0 | PID P73PATHWAY | p73 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 22.2 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 1.7 | 13.8 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 0.5 | 5.7 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 1.3 | 5.3 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.7 | 4.8 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.2 | 3.8 | REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS | Genes involved in Metabolism of lipids and lipoproteins |
| 0.9 | 2.7 | REACTOME SIGNALLING TO ERKS | Genes involved in Signalling to ERKs |
| 0.9 | 2.6 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.4 | 2.3 | REACTOME TRANSLATION | Genes involved in Translation |
| 1.0 | 2.0 | REACTOME G1 PHASE | Genes involved in G1 Phase |