Results for EDS1
Z-value: 1.56
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Transcription factors associated with EDS1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
EDS1
|
S000000237 | Putative zinc cluster protein, predicted to be a transcription factor |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YFR055W Show fit | 51.56 |
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner |
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| YFR056C Show fit | 46.66 |
Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W |
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| YHR094C Show fit | 38.95 |
Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting |
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| YDR345C Show fit | 32.92 |
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions |
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| YNL178W Show fit | 21.93 |
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins |
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| YDR033W Show fit | 19.88 |
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p |
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| YDR279W Show fit | 17.97 |
Ribonuclease H2 subunit, required for RNase H2 activity |
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| YKR075C Show fit | 16.61 |
Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS |
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| YLR154C Show fit | 14.79 |
Ribonuclease H2 subunit, required for RNase H2 activity |
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| YGL209W Show fit | 14.05 |
Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter |
Network of associatons between targets according to the STRING database.
First level regulatory network of EDS1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 145.2 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 17.2 | 51.7 | GO:0000098 | sulfur amino acid catabolic process(GO:0000098) |
| 2.4 | 43.6 | GO:0051029 | rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029) |
| 4.7 | 33.0 | GO:0043137 | DNA replication, removal of RNA primer(GO:0043137) |
| 0.3 | 32.6 | GO:0006364 | rRNA processing(GO:0006364) |
| 3.9 | 15.7 | GO:0036170 | filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436) |
| 0.5 | 15.6 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 0.6 | 13.9 | GO:0006757 | glycolytic process(GO:0006096) nucleoside diphosphate phosphorylation(GO:0006165) ATP generation from ADP(GO:0006757) |
| 0.5 | 11.8 | GO:0002097 | tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098) |
| 1.7 | 11.7 | GO:0010696 | positive regulation of spindle pole body separation(GO:0010696) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 109.5 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 1.0 | 60.3 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.2 | 40.8 | GO:0005933 | cellular bud(GO:0005933) |
| 10.9 | 32.8 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 2.0 | 23.5 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 0.6 | 22.0 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 10.6 | GO:0005886 | plasma membrane(GO:0005886) |
| 0.5 | 10.0 | GO:0031228 | integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228) |
| 0.5 | 9.0 | GO:0022626 | cytosolic ribosome(GO:0022626) |
| 0.1 | 9.0 | GO:0005730 | nucleolus(GO:0005730) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 172.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 6.8 | 40.8 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 8.2 | 32.8 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 6.9 | 27.6 | GO:0015146 | pentose transmembrane transporter activity(GO:0015146) |
| 3.7 | 22.2 | GO:0003906 | DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906) |
| 1.9 | 19.2 | GO:0005216 | ion channel activity(GO:0005216) |
| 0.3 | 16.6 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.1 | 16.6 | GO:0003723 | RNA binding(GO:0003723) |
| 1.0 | 14.9 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.4 | 13.6 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 4.2 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.3 | 3.4 | PID ATR PATHWAY | ATR signaling pathway |
| 1.0 | 2.9 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.3 | 1.3 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.2 | 0.7 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.2 | 0.5 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.1 | 0.5 | PID P73PATHWAY | p73 transcription factor network |
| 0.2 | 0.4 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.1 | 0.4 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 0.3 | 0.3 | PID NOTCH PATHWAY | Notch signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 29.7 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 1.8 | 28.2 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 1.8 | 7.1 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 1.0 | 7.0 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 1.5 | 4.4 | REACTOME SIGNALLING TO ERKS | Genes involved in Signalling to ERKs |
| 0.8 | 3.3 | REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
| 0.7 | 2.9 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 1.2 | 2.5 | REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |
| 0.7 | 2.1 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.6 | 1.8 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |