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Results for EDS1

Z-value: 1.56

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Transcription factors associated with EDS1

Gene Symbol Gene ID Gene Info
EDS1
S000000237 Putative zinc cluster protein, predicted to be a transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
EDS1YBR033W-0.902.8e-10Click!

Activity profile of EDS1 motif

Sorted Z-values of EDS1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YFR055W 51.56
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YFR056C 46.66 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YHR094C 38.95
HXT1
Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YDR345C 32.92
HXT3
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YNL178W 21.93
RPS3
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YDR033W 19.88
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YDR279W 17.97
RNH202
Ribonuclease H2 subunit, required for RNase H2 activity
YKR075C 16.61 Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YLR154C 14.79
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YGL209W 14.05
MIG2
Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter
YFR054C 13.20 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR290C 11.69
HAS1
ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YAL038W 11.36
CDC19
Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration
YLR154W-B 11.32 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YMR290W-A 11.02 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YLR154W-A 10.95 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YDR278C 10.87 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR063W 10.29
RPL3
Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus
YKL218C 9.97
SRY1
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YOR047C 9.95
STD1
Protein involved in control of glucose-regulated gene expression; interacts with protein kinase Snf1p, glucose sensors Snf3p and Rgt2p, and TATA-binding protein Spt15p; acts as a regulator of the transcription factor Rgt1p
YJR094W-A 9.45
RPL43B
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YDR098C 9.38
GRX3
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YOR051C 9.15 Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
YGR108W 8.84
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YMR011W 8.80
HXT2
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YDR344C 8.15 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR376W-A 7.45 Putative protein of unknown function; identified by fungal homology and RT-PCR
YDL023C 7.37 Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
YLR154W-C 7.27
TAR1
Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YHR181W 6.94
SVP26
Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YNL065W 6.92
AQR1
Plasma membrane multidrug transporter of the major facilitator superfamily, confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids
YGL201C 6.65
MCM6
Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YGR052W 6.37
FMP48
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
YDL022W 6.32
GPD1
NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p
YLR198C 6.25 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W
YML026C 6.19
RPS18B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Ap and has similarity to E. coli S13 and rat S18 ribosomal proteins
YLR109W 6.05
AHP1
Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p
YPR157W 6.03 Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YDL022C-A 5.99 Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene DIA3; identified by fungal homology and RT-PCR
YKL110C 5.88
KTI12
Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YDR381W 5.87
YRA1
Nuclear protein that binds to RNA and to Mex67p, required for export of poly(A)+ mRNA from the nucleus; member of the REF (RNA and export factor binding proteins) family; another family member, Yra2p, can substitute for Yra1p function
YOR375C 5.82
GDH1
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources
YGR138C 5.80
TPO2
Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
YMR296C 5.70
LCB1
Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
YHR180W-A 5.66 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3
YBR238C 5.36 Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span
YLR432W 5.33
IMD3
Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
YGR050C 5.26 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIR021W 5.24
MRS1
Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YGL097W 5.21
SRM1
Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
YOR312C 5.19
RPL20B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Ap and has similarity to rat L18a ribosomal protein
YER028C 5.12
MIG3
Probable transcriptional repressor involved in response to toxic agents such as hydroxyurea that inhibit ribonucleotide reductase; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes
YKL060C 5.09
FBA1
Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress
YFL022C 4.88
FRS2
Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
YCR018C 4.83
SRD1
Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YNL096C 4.76
RPS7B
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Ap; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
YHR216W 4.75
IMD2
Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation
YHL015W 4.71
RPS20
Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; has similarity to E. coli S10 and rat S20 ribosomal proteins
YIL169C 4.69 Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene
YGR251W 4.69 Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YER137C 4.67 Putative protein of unknown function
YMR246W 4.55
FAA4
Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipids
YGR139W 4.49 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR095C 4.45 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL202W 4.39
ARO8
Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis
YGL103W 4.37
RPL28
Ribosomal protein of the large (60S) ribosomal subunit, has similarity to E. coli L15 and rat L27a ribosomal proteins; may have peptidyl transferase activity; can mutate to cycloheximide resistance
YBR106W 4.36
PHO88
Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations
YOR029W 4.33 Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YPL143W 4.31
RPL33A
N-terminally acetylated ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Bp and has similarity to rat L35a; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable
YHR092C 4.27
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YLR108C 4.25 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene
YGL157W 4.25 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YKL063C 4.22 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
YGR140W 4.22
CBF2
Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo
YPL178W 4.20
CBC2
Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif
YDR047W 4.15
HEM12
Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; activity inhibited by Cu2+, Zn2+, Fe2+, Fe3+ and sulfhydryl-specific reagents
YML088W 4.03
UFO1
F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation
YGL158W 4.02
RCK1
Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations
YDR418W 3.96
RPL12B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins
YGL148W 3.94
ARO2
Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids
YMR202W 3.89
ERG2
C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis
YHR046C 3.87
INM1
Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate
YLR257W 3.76 Putative protein of unknown function
YOL014W 3.76 Putative protein of unknown function
YER117W 3.75
RPL23B
Protein component of the large (60S) ribosomal subunit, identical to Rpl23Ap and has similarity to E. coli L14 and rat L23 ribosomal proteins
YDL047W 3.73
SIT4
Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
YPR119W 3.72
CLB2
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YDR044W 3.70
HEM13
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YKL219W 3.69
COS9
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YOR050C 3.68 Hypothetical protein
YKR026C 3.67
GCN3
Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression
YGR090W 3.65
UTP22
Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YDR094W 3.64 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
YGL179C 3.63
TOS3
Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YMR205C 3.63
PFK2
Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
YGL135W 3.58
RPL1B
N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Ap and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal
YOR025W 3.58
HST3
Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
YPL075W 3.54
GCR1
Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p
YJL158C 3.50
CIS3
Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
YER036C 3.49
ARB1
ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p
YGR242W 3.48 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
YDL082W 3.44
RPL13A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Bp; not essential for viability; has similarity to rat L13 ribosomal protein
YDR041W 3.44
RSM10
Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
YGR051C 3.43 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene
YBR048W 3.41
RPS11B
Protein component of the small (40S) ribosomal subunit; identical to Rps11Ap and has similarity to E. coli S17 and rat S11 ribosomal proteins
YNR016C 3.39
ACC1
Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids
YLR344W 3.38
RPL26A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Bp and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA
YGR034W 3.36
RPL26B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Ap and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA
YAL003W 3.34
EFB1
Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site
YDL083C 3.33
RPS16B
Protein component of the small (40S) ribosomal subunit; identical to Rps16Ap and has similarity to E. coli S9 and rat S16 ribosomal proteins
YDL037C 3.33
BSC1
Protein of unconfirmed function, similar to cell surface flocculin Muc1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
YOR096W 3.33
RPS7A
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
YLR339C 3.33 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPP0
YKR038C 3.32
KAE1
Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex
YOR226C 3.31
ISU2
Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable
YMR303C 3.29
ADH2
Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1
YLR388W 3.27
RPS29A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Bp and has similarity to rat S29 and E. coli S14 ribosomal proteins
YDL241W 3.24 Putative protein of unknown function; YDL241W is not an essential gene
YNR054C 3.24
ESF2
Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
YNR001W-A 3.24 Dubious open reading frame unlikely to encode a functional protein; identified by homology
YNL090W 3.23
RHO2
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly
YOR028C 3.22
CIN5
Basic leucine zipper transcriptional factor of the yAP-1 family that mediates pleiotropic drug resistance and salt tolerance; localizes constitutively to the nucleus
YGR280C 3.22
PXR1
Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain
YGR085C 3.21
RPL11B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11
YBR112C 3.19
CYC8
General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters
YER031C 3.17
YPT31
GTPase of the Ypt/Rab family, very similar to Ypt32p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi
YKR094C 3.17
RPL40B
Fusion protein, identical to Rpl40Ap, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes
YLR293C 3.15
GSP1
GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; regulated by Prp20p, Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p and Kap95p; yeast Gsp2p homolog
YJL136C 3.14
RPS21B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Ap and has similarity to rat S21 ribosomal protein
YPR148C 3.13 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YLR129W 3.12
DIP2
Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex
YMR242C 3.12
RPL20A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Bp and has similarity to rat L18a ribosomal protein
YML052W 3.09
SUR7
Putative integral membrane protein; component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
YLR340W 3.09
RPP0
Conserved ribosomal protein P0 similar to rat P0, human P0, and E. coli L10e; shown to be phosphorylated on serine 302
YFR032C 3.08 Putative protein of unknown function; transcribed during sporulation; YFR032C is not an essential gene
YNL234W 3.07 Similar to globins and has a functional heme-binding domain; involved in glucose signaling or metabolism; regulated by Rgt1p
YLR110C 3.07
CCW12
Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor
YDL055C 3.05
PSA1
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YGR241C 2.97
YAP1802
Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1801p, member of the AP180 protein family
YJL107C 2.95 Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
YGR037C 2.94
ACB1
Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes
YER124C 2.91
DSE1
Daughter cell-specific protein, may participate in pathways regulating cell wall metabolism; deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall
YGR187C 2.86
HGH1
Nonessential protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16)
YBR182C-A 2.81 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YKL154W 2.80
SRP102
Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors Srp101p to the ER membrane
YDR040C 2.79
ENA1
P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance
YLR325C 2.79
RPL38
Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein
YKL152C 2.77
GPM1
Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
YNL079C 2.76
TPM1
Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently
YDR534C 2.74
FIT1
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YGL031C 2.72
RPL24A
Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YGL102C 2.71 Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein
YMR083W 2.71
ADH3
Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YGL253W 2.70
HXK2
Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene
YBR087W 2.70
RFC5
Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
YNL078W 2.69
NIS1
Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network
YGR157W 2.67
CHO2
Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis
YJR105W 2.67
ADO1
Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
YOR310C 2.66
NOP58
Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA
YOL125W 2.65
TRM13
2'-O-methyltransferase responsible for modification of tRNA at position 4; exhibits no obvious similarity to other known methyltransferases
YPL037C 2.64
EGD1
Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b
YDR146C 2.62
SWI5
Transcription factor that activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase
YNL111C 2.62
CYB5
Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
YOR243C 2.59
PUS7
Pseudouridine synthase, catalyzes pseudouridylation at position 35 in U2 snRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); Asp(256) mutation abolishes activity; conserved in archaea, some bacteria, and vertebrates
YOL130W 2.57
ALR1
Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions
YLR150W 2.56
STM1
Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations
YHR007C 2.55
ERG11
Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family
YJL115W 2.55
ASF1
Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition
YML106W 2.55
URA5
Major orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; minor OPRTase encoded by URA10
YNL113W 2.53
RPC19
RNA polymerase subunit, common to RNA polymerases I and III
YLR285W 2.52
NNT1
Putative nicotinamide N-methyltransferase, has a role in rDNA silencing and in lifespan determination
YPL220W 2.50
RPL1A
N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Bp and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal
YPL197C 2.50 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B
YDL211C 2.48 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YDR371W 2.47
CTS2
Sporulation-specific chitinase
YKL120W 2.46
OAC1
Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, and thiosulfate; member of the mitochondrial carrier family
YDR025W 2.43
RPS11A
Protein component of the small (40S) ribosomal subunit; identical to Rps11Bp and has similarity to E. coli S17 and rat S11 ribosomal proteins
YNL302C 2.41
RPS19B
Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Ap
YIL053W 2.40
RHR2
Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress
YBR113W 2.40 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8
YDR046C 2.39
BAP3
Amino acid permease involved in the uptake of cysteine, leucine, isoleucine and valine
YNL024C 2.39 Putative protein of unknown function with seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL024C is not an essential gene
YGL034C 2.38 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL118C 2.37
DCP2
Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; member of the Nudix hydrolase family
YCR006C 2.35 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDL192W 2.35
ARF1
ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; functionally interchangeable with Arf2p
YGL030W 2.35
RPL30
Protein component of the large (60S) ribosomal subunit, has similarity to rat L30 ribosomal protein; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript
YNR067C 2.35
DSE4
Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother
YIL039W 2.32
TED1
Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YKL166C 2.32
TPK3
cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk1p and Tpk2p
YER023C-A 2.32 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene PRO3; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
YDR509W 2.32 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL096W-A 2.32
CWP2
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YLR249W 2.31
YEF3
Translational elongation factor 3, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex; contains two ABC cassettes; binds and hydrolyses ATP
YNR013C 2.30
PHO91
Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YEL020C-B 2.29 Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene YEL020W-A; identified by fungal homology and RT-PCR
YPL142C 2.28 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit
YDR508C 2.28
GNP1
High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids
YJR076C 2.27
CDC11
Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YPR010C 2.27
RPA135
RNA polymerase I subunit A135

Network of associatons between targets according to the STRING database.

First level regulatory network of EDS1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
17.2 51.7 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
4.7 33.0 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
3.9 15.7 GO:0036170 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
3.5 10.5 GO:0046495 nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637)
2.5 7.4 GO:0006183 GTP biosynthetic process(GO:0006183) GTP metabolic process(GO:0046039)
2.4 43.6 GO:0051029 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
2.1 8.5 GO:0035337 fatty-acyl-CoA metabolic process(GO:0035337)
2.0 8.0 GO:0000296 spermine transport(GO:0000296)
1.8 7.0 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
1.7 5.0 GO:0009094 tyrosine biosynthetic process(GO:0006571) L-phenylalanine biosynthetic process(GO:0009094) erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process(GO:1902223)
1.7 11.7 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
1.7 6.6 GO:0046898 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
1.6 4.9 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
1.6 3.1 GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000461)
1.5 4.6 GO:0046855 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
1.5 2.9 GO:0015909 long-chain fatty acid transport(GO:0015909)
1.4 1.4 GO:0061422 positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH(GO:0061422)
1.4 5.4 GO:0071478 cellular response to radiation(GO:0071478) cellular response to light stimulus(GO:0071482)
1.3 5.1 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
1.3 6.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
1.2 10.5 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
1.1 3.3 GO:0072361 regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361) regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072363)
1.1 7.6 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
1.1 3.2 GO:2000877 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
1.1 145.2 GO:0002181 cytoplasmic translation(GO:0002181)
1.0 4.1 GO:0009423 chorismate biosynthetic process(GO:0009423) chorismate metabolic process(GO:0046417)
1.0 3.0 GO:0009298 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
1.0 1.0 GO:0071850 mitotic cell cycle arrest in response to pheromone(GO:0000751) mitotic cell cycle arrest(GO:0071850)
1.0 2.9 GO:1904667 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.9 8.5 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.9 6.6 GO:0006116 NADH oxidation(GO:0006116)
0.9 3.7 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211) negative regulation of telomere maintenance via telomere lengthening(GO:1904357)
0.9 7.4 GO:0015758 glucose transport(GO:0015758)
0.9 2.6 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.9 1.8 GO:0006021 inositol biosynthetic process(GO:0006021)
0.9 3.5 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
0.9 3.4 GO:0046490 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490)
0.9 2.6 GO:0060548 negative regulation of apoptotic process(GO:0043066) negative regulation of programmed cell death(GO:0043069) negative regulation of cell death(GO:0060548)
0.8 5.9 GO:0006855 drug transmembrane transport(GO:0006855)
0.8 2.5 GO:0006114 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.8 1.7 GO:0006110 regulation of glycolytic process(GO:0006110)
0.8 2.5 GO:0008272 sulfate transport(GO:0008272)
0.8 2.4 GO:0015693 magnesium ion transport(GO:0015693)
0.8 2.4 GO:1901351 regulation of phosphatidylglycerol biosynthetic process(GO:1901351) negative regulation of phosphatidylglycerol biosynthetic process(GO:1901352)
0.8 2.3 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.7 2.2 GO:0045901 positive regulation of translational elongation(GO:0045901)
0.7 7.8 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.7 3.5 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.7 4.1 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.7 4.1 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.7 2.0 GO:0052646 alditol phosphate metabolic process(GO:0052646)
0.7 4.0 GO:0007119 budding cell isotropic bud growth(GO:0007119)
0.7 2.7 GO:0071406 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
0.7 2.7 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.7 5.3 GO:0000376 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.7 1.3 GO:0006798 polyphosphate catabolic process(GO:0006798)
0.6 0.6 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.6 3.1 GO:0007535 donor selection(GO:0007535)
0.6 4.4 GO:0006797 polyphosphate metabolic process(GO:0006797)
0.6 2.5 GO:0045896 regulation of transcription during mitosis(GO:0045896)
0.6 13.9 GO:0006757 glycolytic process(GO:0006096) nucleoside diphosphate phosphorylation(GO:0006165) ATP generation from ADP(GO:0006757)
0.6 3.0 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.6 1.8 GO:0006636 unsaturated fatty acid biosynthetic process(GO:0006636) unsaturated fatty acid metabolic process(GO:0033559)
0.6 1.7 GO:0006177 GMP biosynthetic process(GO:0006177)
0.6 2.2 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.6 2.2 GO:0098609 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.5 1.6 GO:0060188 regulation of protein desumoylation(GO:0060188)
0.5 1.6 GO:0046677 response to antibiotic(GO:0046677)
0.5 15.6 GO:0045454 cell redox homeostasis(GO:0045454)
0.5 2.1 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
0.5 2.1 GO:0030497 fatty acid elongation(GO:0030497)
0.5 2.1 GO:0034473 U1 snRNA 3'-end processing(GO:0034473)
0.5 1.6 GO:0031120 snRNA pseudouridine synthesis(GO:0031120) snRNA modification(GO:0040031)
0.5 2.1 GO:0006026 aminoglycan catabolic process(GO:0006026) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.5 2.6 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.5 5.0 GO:0051231 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231)
0.5 0.5 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.5 11.6 GO:0006696 ergosterol biosynthetic process(GO:0006696) phytosteroid biosynthetic process(GO:0016129) cellular alcohol biosynthetic process(GO:0044108) cellular lipid biosynthetic process(GO:0097384)
0.5 5.8 GO:0006037 cell wall chitin metabolic process(GO:0006037)
0.5 1.9 GO:0001402 signal transduction involved in filamentous growth(GO:0001402)
0.5 3.8 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
0.5 6.1 GO:0006972 hyperosmotic response(GO:0006972)
0.5 11.8 GO:0002097 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.5 1.9 GO:0031590 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.5 2.3 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.5 8.4 GO:0042797 tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.5 4.7 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.5 0.9 GO:0046939 nucleotide phosphorylation(GO:0046939)
0.5 1.8 GO:0015680 intracellular copper ion transport(GO:0015680)
0.5 1.4 GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process(GO:0071042) polyadenylation-dependent mRNA catabolic process(GO:0071047)
0.4 2.2 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.4 2.7 GO:0044205 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.4 1.7 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.4 0.4 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972) negative regulation of cell cycle G2/M phase transition(GO:1902750)
0.4 4.3 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.4 2.6 GO:0070941 eisosome assembly(GO:0070941)
0.4 10.7 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.4 0.4 GO:0010383 cell wall polysaccharide metabolic process(GO:0010383)
0.4 1.2 GO:0031114 negative regulation of microtubule depolymerization(GO:0007026) negative regulation of microtubule polymerization or depolymerization(GO:0031111) regulation of microtubule depolymerization(GO:0031114)
0.4 5.8 GO:0030488 tRNA methylation(GO:0030488)
0.4 2.5 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.4 1.2 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.4 1.2 GO:0018216 peptidyl-arginine modification(GO:0018195) peptidyl-arginine methylation(GO:0018216)
0.4 1.6 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.4 0.8 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362)
0.4 1.6 GO:1903530 regulation of exocytosis(GO:0017157) regulation of secretion(GO:0051046) regulation of secretion by cell(GO:1903530)
0.4 2.3 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.4 4.9 GO:0031125 rRNA 3'-end processing(GO:0031125)
0.4 0.7 GO:2000197 regulation of mRNA export from nucleus(GO:0010793) regulation of nucleobase-containing compound transport(GO:0032239) regulation of RNA export from nucleus(GO:0046831) regulation of ribonucleoprotein complex localization(GO:2000197)
0.4 2.6 GO:0009312 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.4 5.9 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.4 2.2 GO:0048478 replication fork protection(GO:0048478)
0.4 4.3 GO:0006415 translational termination(GO:0006415)
0.4 1.8 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.4 1.8 GO:0046655 folic acid metabolic process(GO:0046655) folic acid biosynthetic process(GO:0046656)
0.4 1.8 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.4 1.1 GO:0000076 DNA replication checkpoint(GO:0000076)
0.4 1.1 GO:0046083 purine nucleobase salvage(GO:0043096) adenine metabolic process(GO:0046083)
0.4 5.7 GO:0006446 regulation of translational initiation(GO:0006446)
0.4 3.5 GO:0006272 leading strand elongation(GO:0006272)
0.3 1.4 GO:0007234 osmosensory signaling via phosphorelay pathway(GO:0007234)
0.3 1.0 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
0.3 8.2 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.3 3.7 GO:0007009 plasma membrane organization(GO:0007009)
0.3 3.3 GO:0044036 cell wall macromolecule metabolic process(GO:0044036)
0.3 0.6 GO:0019856 pyrimidine nucleobase biosynthetic process(GO:0019856)
0.3 1.0 GO:0031047 gene silencing involved in chronological cell aging(GO:0010978) gene silencing by RNA(GO:0031047)
0.3 0.9 GO:0042256 mature ribosome assembly(GO:0042256)
0.3 1.6 GO:0034063 stress granule assembly(GO:0034063)
0.3 0.9 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.3 1.2 GO:0031032 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin structure organization(GO:0031032) actomyosin contractile ring organization(GO:0044837)
0.3 0.9 GO:0034724 DNA replication-independent nucleosome organization(GO:0034724)
0.3 1.8 GO:0007030 Golgi organization(GO:0007030)
0.3 0.6 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.3 0.3 GO:0033239 negative regulation of cellular amine metabolic process(GO:0033239)
0.3 0.9 GO:0000433 negative regulation of transcription from RNA polymerase II promoter by glucose(GO:0000433) negative regulation of transcription by glucose(GO:0045014)
0.3 1.8 GO:0034729 histone H3-K79 methylation(GO:0034729)
0.3 0.9 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.3 0.6 GO:0031384 regulation of initiation of mating projection growth(GO:0031384)
0.3 1.5 GO:0006734 NADH metabolic process(GO:0006734)
0.3 2.3 GO:0045860 positive regulation of protein kinase activity(GO:0045860)
0.3 1.1 GO:0043489 RNA stabilization(GO:0043489) mRNA stabilization(GO:0048255)
0.3 0.6 GO:0090088 regulation of peptide transport(GO:0090087) regulation of oligopeptide transport(GO:0090088) regulation of dipeptide transport(GO:0090089)
0.3 6.1 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.3 3.3 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.3 1.6 GO:0009088 threonine biosynthetic process(GO:0009088)
0.3 0.5 GO:0016320 endoplasmic reticulum membrane fusion(GO:0016320)
0.3 2.4 GO:0006817 phosphate ion transport(GO:0006817)
0.3 0.8 GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)(GO:0019379) sulfate reduction(GO:0019419)
0.3 0.8 GO:0009177 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) deoxyribonucleoside monophosphate metabolic process(GO:0009162) pyrimidine deoxyribonucleoside monophosphate metabolic process(GO:0009176) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177)
0.3 32.6 GO:0006364 rRNA processing(GO:0006364)
0.3 1.1 GO:2000278 regulation of telomere maintenance via telomerase(GO:0032210) regulation of telomere maintenance via telomere lengthening(GO:1904356) regulation of DNA biosynthetic process(GO:2000278)
0.3 3.4 GO:0007120 axial cellular bud site selection(GO:0007120)
0.3 0.5 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.3 1.0 GO:0048279 vesicle fusion with endoplasmic reticulum(GO:0048279)
0.3 0.8 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900) tetrahydrofolylpolyglutamate biosynthetic process(GO:0046901)
0.3 1.5 GO:0006857 oligopeptide transport(GO:0006857)
0.3 2.0 GO:0006694 steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126)
0.2 1.5 GO:0009099 valine biosynthetic process(GO:0009099)
0.2 1.5 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.2 3.1 GO:0006613 cotranslational protein targeting to membrane(GO:0006613) SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.2 4.2 GO:0098876 Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.2 0.5 GO:0030846 termination of RNA polymerase II transcription, poly(A)-coupled(GO:0030846)
0.2 3.5 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.2 0.5 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.2 0.2 GO:2000002 regulation of cell cycle checkpoint(GO:1901976) negative regulation of cell cycle checkpoint(GO:1901977) regulation of DNA damage checkpoint(GO:2000001) negative regulation of DNA damage checkpoint(GO:2000002) negative regulation of response to DNA damage stimulus(GO:2001021)
0.2 0.9 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.2 2.5 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.2 5.5 GO:0006414 translational elongation(GO:0006414)
0.2 6.5 GO:0051445 regulation of meiotic nuclear division(GO:0040020) regulation of meiotic cell cycle(GO:0051445)
0.2 1.1 GO:0016233 telomere capping(GO:0016233)
0.2 1.9 GO:0090662 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.2 1.0 GO:0009073 aromatic amino acid family biosynthetic process(GO:0009073)
0.2 1.8 GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay(GO:0070481)
0.2 1.2 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.2 0.2 GO:0032447 protein urmylation(GO:0032447)
0.2 1.0 GO:0009098 leucine biosynthetic process(GO:0009098)
0.2 0.8 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.2 1.2 GO:0045116 protein neddylation(GO:0045116)
0.2 1.4 GO:0007323 peptide pheromone maturation(GO:0007323)
0.2 1.7 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.2 0.6 GO:0051238 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.2 0.4 GO:0070813 hydrogen sulfide metabolic process(GO:0070813) hydrogen sulfide biosynthetic process(GO:0070814)
0.2 1.9 GO:0009435 NAD biosynthetic process(GO:0009435)
0.2 1.0 GO:0060304 regulation of phosphatidylinositol dephosphorylation(GO:0060304) endoplasmic reticulum membrane organization(GO:0090158)
0.2 0.2 GO:0072600 protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.2 0.7 GO:0030031 cell projection organization(GO:0030030) cell projection assembly(GO:0030031)
0.2 0.2 GO:0045981 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.2 0.5 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.2 1.5 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.2 3.0 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.2 3.0 GO:0006378 mRNA polyadenylation(GO:0006378)
0.2 0.6 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.2 0.2 GO:0010942 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.2 5.5 GO:0032259 methylation(GO:0032259)
0.2 2.2 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.2 0.3 GO:0006784 heme a biosynthetic process(GO:0006784) heme a metabolic process(GO:0046160)
0.2 1.4 GO:0000105 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.1 4.6 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.1 0.1 GO:0006531 aspartate metabolic process(GO:0006531)
0.1 1.5 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.1 1.0 GO:0009395 phospholipid catabolic process(GO:0009395)
0.1 1.3 GO:0006743 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) ketone biosynthetic process(GO:0042181) quinone metabolic process(GO:1901661) quinone biosynthetic process(GO:1901663)
0.1 0.1 GO:0051322 anaphase(GO:0051322)
0.1 0.7 GO:0097354 protein prenylation(GO:0018342) prenylation(GO:0097354)
0.1 0.3 GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger(GO:0007187) adenylate cyclase-modulating G-protein coupled receptor signaling pathway(GO:0007188)
0.1 0.7 GO:0035376 sterol import(GO:0035376)
0.1 0.3 GO:0016093 polyprenol metabolic process(GO:0016093) polyprenol biosynthetic process(GO:0016094) dolichol metabolic process(GO:0019348) dolichol biosynthetic process(GO:0019408)
0.1 0.5 GO:0035753 maintenance of DNA trinucleotide repeats(GO:0035753)
0.1 0.3 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.1 0.3 GO:0033875 coenzyme A metabolic process(GO:0015936) nucleoside bisphosphate metabolic process(GO:0033865) ribonucleoside bisphosphate metabolic process(GO:0033875) purine nucleoside bisphosphate metabolic process(GO:0034032)
0.1 0.5 GO:0015780 nucleotide-sugar transport(GO:0015780)
0.1 0.3 GO:0009226 nucleotide-sugar biosynthetic process(GO:0009226)
0.1 0.4 GO:1902807 negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.1 1.2 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 0.5 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.1 1.1 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.1 0.4 GO:0051038 negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010674) negative regulation of transcription involved in meiotic cell cycle(GO:0051038)
0.1 0.4 GO:0043244 negative regulation of protein complex disassembly(GO:0043242) regulation of protein complex disassembly(GO:0043244)
0.1 0.5 GO:0071331 cellular glucose homeostasis(GO:0001678) carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255) carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.1 0.2 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.1 2.7 GO:0006413 translational initiation(GO:0006413)
0.1 1.0 GO:0030011 maintenance of cell polarity(GO:0030011)
0.1 1.8 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023) nucleus localization(GO:0051647)
0.1 0.6 GO:0000087 mitotic M phase(GO:0000087) M phase(GO:0000279)
0.1 0.2 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.1 0.5 GO:0009306 protein secretion(GO:0009306)
0.1 1.0 GO:0055070 cellular copper ion homeostasis(GO:0006878) copper ion homeostasis(GO:0055070)
0.1 1.5 GO:0043094 cellular metabolic compound salvage(GO:0043094)
0.1 0.4 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.1 0.2 GO:0009847 spore germination(GO:0009847)
0.1 0.3 GO:0046473 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.1 1.1 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.1 0.3 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.1 2.5 GO:0006606 protein import into nucleus(GO:0006606) nuclear import(GO:0051170) single-organism nuclear import(GO:1902593)
0.1 2.9 GO:0007015 actin filament organization(GO:0007015)
0.1 0.5 GO:0000707 meiotic DNA recombinase assembly(GO:0000707) DNA recombinase assembly(GO:0000730)
0.1 1.0 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.1 0.2 GO:0035459 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.1 0.7 GO:0000917 barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529)
0.1 0.3 GO:0060277 obsolete negative regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0060277)
0.1 0.7 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.1 0.3 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.1 0.2 GO:0019674 NAD metabolic process(GO:0019674)
0.1 1.4 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.1 0.1 GO:0034517 ribophagy(GO:0034517)
0.1 0.1 GO:0007050 cell cycle arrest(GO:0007050)
0.1 0.5 GO:0006188 IMP biosynthetic process(GO:0006188) 'de novo' IMP biosynthetic process(GO:0006189) IMP metabolic process(GO:0046040)
0.1 0.2 GO:0009371 positive regulation of transcription from RNA polymerase II promoter by pheromones(GO:0007329) positive regulation of transcription by pheromones(GO:0009371)
0.1 1.2 GO:0008033 tRNA processing(GO:0008033)
0.1 0.2 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.1 0.7 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 0.3 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.1 2.1 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.1 0.6 GO:0032940 secretion by cell(GO:0032940) secretion(GO:0046903)
0.1 0.4 GO:0071709 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.1 3.3 GO:0048193 Golgi vesicle transport(GO:0048193)
0.1 0.5 GO:0045851 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.1 0.2 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1 0.2 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.1 0.2 GO:0009164 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.1 0.2 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
0.1 0.1 GO:0071025 RNA surveillance(GO:0071025) nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.0 0.2 GO:0048278 vesicle docking(GO:0048278)
0.0 0.4 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.1 GO:0032006 regulation of TOR signaling(GO:0032006)
0.0 0.4 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.0 0.3 GO:0006353 DNA-templated transcription, termination(GO:0006353)
0.0 1.3 GO:0007088 regulation of mitotic nuclear division(GO:0007088)
0.0 1.7 GO:0016311 dephosphorylation(GO:0016311)
0.0 0.1 GO:0045013 carbon catabolite repression of transcription(GO:0045013)
0.0 0.2 GO:0000084 mitotic S phase(GO:0000084) S phase(GO:0051320)
0.0 0.1 GO:1903726 negative regulation of phospholipid biosynthetic process(GO:0071072) negative regulation of phospholipid metabolic process(GO:1903726)
0.0 0.4 GO:0000077 DNA damage checkpoint(GO:0000077)
0.0 0.1 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.0 0.2 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity(GO:0051090)
0.0 0.2 GO:0016125 steroid metabolic process(GO:0008202) sterol metabolic process(GO:0016125)
0.0 0.4 GO:0032986 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 0.1 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.0 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.6 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 0.1 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.0 0.1 GO:0006284 base-excision repair(GO:0006284)
0.0 1.0 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.0 GO:0001109 promoter clearance during DNA-templated transcription(GO:0001109) promoter clearance from RNA polymerase II promoter(GO:0001111)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
10.9 32.8 GO:0032299 ribonuclease H2 complex(GO:0032299)
2.5 7.5 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
2.0 23.5 GO:0030688 preribosome, small subunit precursor(GO:0030688)
1.3 109.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
1.2 6.0 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
1.2 7.0 GO:0042555 MCM complex(GO:0042555)
1.1 4.5 GO:0031518 CBF3 complex(GO:0031518)
1.1 3.4 GO:0072687 meiotic spindle(GO:0072687)
1.1 6.7 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
1.0 5.2 GO:0034518 RNA cap binding complex(GO:0034518)
1.0 4.1 GO:0031429 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
1.0 60.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.9 6.4 GO:0000346 transcription export complex(GO:0000346)
0.9 5.5 GO:0032126 eisosome(GO:0032126)
0.9 3.6 GO:0017053 transcriptional repressor complex(GO:0017053)
0.9 5.4 GO:0034456 UTP-C complex(GO:0034456)
0.9 2.6 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.9 3.5 GO:0070860 RNA polymerase I core factor complex(GO:0070860)
0.8 4.0 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.8 2.4 GO:0030689 Noc complex(GO:0030689)
0.8 2.3 GO:0030428 cell septum(GO:0030428)
0.8 4.6 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.7 2.2 GO:0005662 DNA replication factor A complex(GO:0005662)
0.7 3.7 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.7 2.1 GO:0097344 Rix1 complex(GO:0097344)
0.7 0.7 GO:0005940 septin ring(GO:0005940) septin cytoskeleton(GO:0032156)
0.7 2.1 GO:0070545 PeBoW complex(GO:0070545)
0.7 3.3 GO:0005663 DNA replication factor C complex(GO:0005663)
0.7 2.7 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.6 8.7 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.6 22.0 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.6 0.6 GO:0000133 polarisome(GO:0000133)
0.6 2.2 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.6 3.9 GO:0032432 actin filament bundle(GO:0032432)
0.5 2.7 GO:0034044 exomer complex(GO:0034044)
0.5 9.0 GO:0022626 cytosolic ribosome(GO:0022626)
0.5 5.7 GO:0030867 rough endoplasmic reticulum(GO:0005791) rough endoplasmic reticulum membrane(GO:0030867)
0.5 7.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.5 10.0 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.5 1.4 GO:0045298 polar microtubule(GO:0005827) tubulin complex(GO:0045298)
0.4 1.3 GO:0000814 ESCRT II complex(GO:0000814)
0.4 1.7 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.4 2.1 GO:0005641 nuclear envelope lumen(GO:0005641)
0.4 3.4 GO:0030126 COPI vesicle coat(GO:0030126)
0.4 1.3 GO:0070985 TFIIK complex(GO:0070985)
0.4 1.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.4 2.9 GO:0033180 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.4 2.5 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.4 2.9 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.4 1.2 GO:0000137 Golgi cis cisterna(GO:0000137)
0.4 3.2 GO:0031933 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.4 0.8 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.4 2.3 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.4 1.1 GO:0000930 gamma-tubulin small complex, spindle pole body(GO:0000928) gamma-tubulin complex(GO:0000930) gamma-tubulin small complex(GO:0008275)
0.3 1.3 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.3 0.3 GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network(GO:0042175)
0.3 1.0 GO:0000131 incipient cellular bud site(GO:0000131)
0.3 1.0 GO:0070823 HDA1 complex(GO:0070823)
0.3 0.6 GO:0016363 nuclear matrix(GO:0016363)
0.3 4.1 GO:0000786 nucleosome(GO:0000786)
0.3 2.3 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.3 3.9 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.3 1.1 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.3 2.7 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.3 1.1 GO:0005797 Golgi medial cisterna(GO:0005797)
0.3 0.8 GO:0030133 transport vesicle(GO:0030133)
0.2 2.0 GO:0005688 U6 snRNP(GO:0005688)
0.2 1.7 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.2 0.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 0.7 GO:0032176 split septin rings(GO:0032176) cellular bud neck split septin rings(GO:0032177)
0.2 1.9 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.2 8.3 GO:0005811 lipid particle(GO:0005811)
0.2 0.9 GO:0030892 mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990)
0.2 3.5 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.2 40.8 GO:0005933 cellular bud(GO:0005933)
0.2 1.5 GO:0072686 mitotic spindle(GO:0072686)
0.2 0.8 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.2 0.8 GO:0000938 GARP complex(GO:0000938)
0.2 4.0 GO:0032040 small-subunit processome(GO:0032040)
0.2 1.1 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.2 1.1 GO:0016272 prefoldin complex(GO:0016272)
0.2 0.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 5.1 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.2 0.9 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.2 1.1 GO:0051233 spindle midzone(GO:0051233)
0.2 2.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 0.5 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.2 3.1 GO:0016586 RSC complex(GO:0016586)
0.2 4.7 GO:0005844 polysome(GO:0005844)
0.2 1.2 GO:0034399 nuclear periphery(GO:0034399)
0.2 0.8 GO:0030125 clathrin vesicle coat(GO:0030125)
0.2 0.6 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967) pyruvate dehydrogenase complex(GO:0045254)
0.1 1.0 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.1 0.4 GO:0005771 multivesicular body(GO:0005771)
0.1 1.1 GO:0031201 SNARE complex(GO:0031201)
0.1 0.5 GO:0030907 MBF transcription complex(GO:0030907)
0.1 0.5 GO:0055087 Ski complex(GO:0055087)
0.1 2.4 GO:0005798 Golgi-associated vesicle(GO:0005798)
0.1 4.0 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 1.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 0.5 GO:0034448 EGO complex(GO:0034448)
0.1 0.3 GO:0097255 R2TP complex(GO:0097255)
0.1 2.3 GO:0030684 preribosome(GO:0030684)
0.1 0.7 GO:0005871 kinesin complex(GO:0005871)
0.1 0.4 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 0.4 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.1 0.2 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.1 3.8 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 1.6 GO:0046695 SLIK (SAGA-like) complex(GO:0046695)
0.1 1.0 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 0.4 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.1 0.1 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.1 2.6 GO:0099512 supramolecular fiber(GO:0099512) polymeric cytoskeletal fiber(GO:0099513)
0.1 0.4 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.1 9.0 GO:0005730 nucleolus(GO:0005730)
0.1 1.6 GO:0005685 U1 snRNP(GO:0005685)
0.1 0.8 GO:0032541 cortical endoplasmic reticulum(GO:0032541) endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.1 0.6 GO:0017119 Golgi transport complex(GO:0017119)
0.1 2.5 GO:0005794 Golgi apparatus(GO:0005794)
0.1 0.1 GO:0000798 nuclear cohesin complex(GO:0000798) cohesin complex(GO:0008278)
0.1 0.5 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 3.3 GO:0005635 nuclear envelope(GO:0005635)
0.1 0.4 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 0.1 GO:0000145 exocyst(GO:0000145)
0.1 0.1 GO:0016459 myosin complex(GO:0016459)
0.1 0.2 GO:0005796 Golgi lumen(GO:0005796)
0.1 0.3 GO:0070772 PAS complex(GO:0070772)
0.0 0.2 GO:0033176 vacuolar proton-transporting V-type ATPase complex(GO:0016471) proton-transporting V-type ATPase complex(GO:0033176)
0.0 0.1 GO:0044611 nuclear pore inner ring(GO:0044611)
0.0 0.0 GO:0030904 retromer complex(GO:0030904)
0.0 0.3 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 2.1 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.2 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.2 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.4 GO:0071004 U2-type prespliceosome(GO:0071004) prespliceosome(GO:0071010)
0.0 0.1 GO:0033597 mitotic checkpoint complex(GO:0033597)
0.0 10.6 GO:0005886 plasma membrane(GO:0005886)
0.0 0.1 GO:0000811 GINS complex(GO:0000811)
0.0 7.2 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 2.5 GO:0005840 ribosome(GO:0005840)
0.0 0.1 GO:0046930 pore complex(GO:0046930)
0.0 0.2 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.2 GO:0032806 carboxy-terminal domain protein kinase complex(GO:0032806)
0.0 0.5 GO:0005815 microtubule organizing center(GO:0005815) spindle pole body(GO:0005816)
0.0 0.1 GO:0031417 NatC complex(GO:0031417)
0.0 0.1 GO:0042575 DNA polymerase complex(GO:0042575)
0.0 0.2 GO:0034708 methyltransferase complex(GO:0034708)
0.0 0.1 GO:0036452 ESCRT complex(GO:0036452)
0.0 0.1 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.0 0.0 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.0 0.1 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.2 GO:0005849 mRNA cleavage factor complex(GO:0005849)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
8.2 32.8 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
6.9 27.6 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
6.8 40.8 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
3.8 11.4 GO:0003938 IMP dehydrogenase activity(GO:0003938)
3.7 22.2 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
2.5 9.9 GO:0016841 ammonia-lyase activity(GO:0016841)
2.0 8.0 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
1.9 19.2 GO:0005216 ion channel activity(GO:0005216)
1.7 6.9 GO:0009378 four-way junction helicase activity(GO:0009378)
1.6 4.9 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
1.5 4.4 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
1.4 4.2 GO:0000339 RNA cap binding(GO:0000339)
1.3 5.4 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
1.3 5.1 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
1.3 5.0 GO:0016832 aldehyde-lyase activity(GO:0016832)
1.3 7.5 GO:0016408 C-acyltransferase activity(GO:0016408)
1.2 12.3 GO:0015578 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
1.2 3.6 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
1.2 4.8 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
1.1 6.5 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
1.1 5.3 GO:0070546 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
1.0 5.2 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
1.0 3.0 GO:0070568 guanylyltransferase activity(GO:0070568)
1.0 14.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.0 3.0 GO:0010521 telomerase inhibitor activity(GO:0010521)
1.0 1.0 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825)
0.9 6.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.9 5.1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.8 3.4 GO:0019206 nucleoside kinase activity(GO:0019206)
0.8 9.2 GO:0030295 protein kinase activator activity(GO:0030295)
0.8 172.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.8 2.5 GO:0015116 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.8 2.4 GO:0019003 GDP binding(GO:0019003)
0.8 2.3 GO:0004691 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.8 2.3 GO:0051219 phosphoprotein binding(GO:0051219)
0.7 2.2 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
0.7 4.2 GO:0019237 centromeric DNA binding(GO:0019237)
0.7 8.8 GO:0003746 translation elongation factor activity(GO:0003746)
0.7 2.7 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.7 3.4 GO:0070403 NAD+ binding(GO:0070403)
0.7 2.0 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.7 6.0 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.7 3.3 GO:0008443 phosphofructokinase activity(GO:0008443)
0.6 2.5 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
0.6 5.0 GO:1901681 sulfur compound binding(GO:1901681)
0.6 8.7 GO:0001054 RNA polymerase I activity(GO:0001054)
0.6 3.1 GO:0008536 Ran GTPase binding(GO:0008536)
0.6 2.3 GO:0042973 glucan endo-1,3-beta-D-glucosidase activity(GO:0042973)
0.6 1.8 GO:0004100 chitin synthase activity(GO:0004100)
0.6 1.7 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.6 1.7 GO:0016872 intramolecular lyase activity(GO:0016872)
0.6 11.9 GO:0019901 protein kinase binding(GO:0019901)
0.6 2.8 GO:0008526 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.6 1.7 GO:0009922 fatty acid elongase activity(GO:0009922)
0.5 3.3 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.5 1.6 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.5 6.8 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.5 2.0 GO:0004622 lysophospholipase activity(GO:0004622)
0.5 0.5 GO:0033592 RNA strand annealing activity(GO:0033592) annealing activity(GO:0097617)
0.5 8.3 GO:0042803 protein homodimerization activity(GO:0042803)
0.5 1.4 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.5 3.3 GO:0030145 manganese ion binding(GO:0030145)
0.5 1.4 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.5 1.8 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.4 4.9 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.4 13.6 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.4 1.7 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.4 1.3 GO:0015248 sterol transporter activity(GO:0015248)
0.4 2.2 GO:0004707 MAP kinase activity(GO:0004707)
0.4 1.3 GO:0004805 trehalose-phosphatase activity(GO:0004805)
0.4 1.7 GO:0008172 S-methyltransferase activity(GO:0008172)
0.4 3.3 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.4 1.2 GO:0016273 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.4 1.6 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.4 1.2 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.4 3.5 GO:0000009 alpha-1,6-mannosyltransferase activity(GO:0000009)
0.4 1.1 GO:0016882 cyclo-ligase activity(GO:0016882)
0.4 1.5 GO:0004017 adenylate kinase activity(GO:0004017)
0.4 1.8 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.4 1.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.4 1.4 GO:0004771 sterol esterase activity(GO:0004771)
0.3 0.7 GO:0019201 nucleotide kinase activity(GO:0019201)
0.3 1.0 GO:0016504 peptidase activator activity(GO:0016504)
0.3 1.4 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.3 5.7 GO:0042162 telomeric DNA binding(GO:0042162)
0.3 2.4 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.3 1.9 GO:0008312 7S RNA binding(GO:0008312)
0.3 2.9 GO:0031490 chromatin DNA binding(GO:0031490)
0.3 4.1 GO:0051015 actin filament binding(GO:0051015)
0.3 6.3 GO:0008170 N-methyltransferase activity(GO:0008170)
0.3 0.9 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.3 16.6 GO:0003924 GTPase activity(GO:0003924)
0.3 5.0 GO:0030515 snoRNA binding(GO:0030515)
0.3 2.3 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.3 8.5 GO:0008135 translation factor activity, RNA binding(GO:0008135)
0.3 0.9 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.3 1.1 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.3 4.5 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.3 3.3 GO:0005199 structural constituent of cell wall(GO:0005199)
0.3 2.7 GO:0001056 RNA polymerase III activity(GO:0001056)
0.3 1.4 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.3 1.1 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.3 0.8 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.3 0.8 GO:0004326 tetrahydrofolylpolyglutamate synthase activity(GO:0004326)
0.3 4.4 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.3 0.8 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
0.3 2.5 GO:0003727 single-stranded RNA binding(GO:0003727)
0.2 1.0 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.2 0.9 GO:0055103 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.2 0.9 GO:0008252 nucleotidase activity(GO:0008252)
0.2 0.4 GO:0051010 microtubule plus-end binding(GO:0051010)
0.2 1.1 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.2 3.9 GO:0008017 microtubule binding(GO:0008017)
0.2 3.0 GO:0070566 adenylyltransferase activity(GO:0070566)
0.2 1.0 GO:0017137 Rab GTPase binding(GO:0017137)
0.2 2.0 GO:0004177 aminopeptidase activity(GO:0004177)
0.2 0.6 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.2 5.8 GO:0046982 protein heterodimerization activity(GO:0046982)
0.2 0.4 GO:0031370 eukaryotic initiation factor 4G binding(GO:0031370)
0.2 2.2 GO:0019843 rRNA binding(GO:0019843)
0.2 1.6 GO:0005516 calmodulin binding(GO:0005516)
0.2 1.4 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.2 1.4 GO:0003724 RNA helicase activity(GO:0003724)
0.2 0.6 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.2 5.3 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.2 0.9 GO:0017048 Rho GTPase binding(GO:0017048)
0.2 5.9 GO:0030674 protein binding, bridging(GO:0030674)
0.2 0.2 GO:0008142 oxysterol binding(GO:0008142)
0.2 0.3 GO:0016840 carbon-nitrogen lyase activity(GO:0016840)
0.2 3.1 GO:0015926 glucosidase activity(GO:0015926)
0.2 0.8 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.2 2.6 GO:0003774 motor activity(GO:0003774)
0.2 1.5 GO:0015631 tubulin binding(GO:0015631)
0.2 1.7 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.2 0.5 GO:0008235 metalloexopeptidase activity(GO:0008235)
0.2 0.8 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.2 0.5 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.1 0.7 GO:0008318 protein prenyltransferase activity(GO:0008318)
0.1 0.4 GO:0032934 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.1 0.8 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen(GO:0016705)
0.1 7.4 GO:0016791 phosphatase activity(GO:0016791)
0.1 0.8 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.1 1.8 GO:0001671 ATPase activator activity(GO:0001671)
0.1 1.3 GO:0004407 histone deacetylase activity(GO:0004407) protein deacetylase activity(GO:0033558)
0.1 0.5 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.1 1.1 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.1 0.5 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 1.0 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.1 0.6 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.1 0.4 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 0.9 GO:0016866 intramolecular transferase activity(GO:0016866)
0.1 0.3 GO:0008242 omega peptidase activity(GO:0008242)
0.1 0.3 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.1 0.5 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.1 0.2 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 0.3 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)
0.1 2.9 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.1 0.3 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 0.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 2.4 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.1 1.2 GO:0005048 signal sequence binding(GO:0005048)
0.1 1.5 GO:0015616 DNA translocase activity(GO:0015616)
0.1 4.3 GO:0008565 protein transporter activity(GO:0008565)
0.1 0.8 GO:0019239 deaminase activity(GO:0019239)
0.1 0.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 0.8 GO:0015079 potassium ion transmembrane transporter activity(GO:0015079)
0.1 16.6 GO:0003723 RNA binding(GO:0003723)
0.1 0.1 GO:0001187 transcription factor activity, RNA polymerase I CORE element sequence-specific binding(GO:0001169) transcription factor activity, RNA polymerase I transcription factor recruiting(GO:0001186) transcription factor activity, RNA polymerase I CORE element binding transcription factor recruiting(GO:0001187)
0.1 0.3 GO:0019900 kinase binding(GO:0019900)
0.1 1.3 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 1.8 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 1.2 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.1 1.1 GO:0015238 drug transmembrane transporter activity(GO:0015238)
0.1 0.2 GO:0042736 NAD+ kinase activity(GO:0003951) NADH kinase activity(GO:0042736)
0.1 0.1 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.1 0.6 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 0.7 GO:0000991 transcription factor activity, core RNA polymerase II binding(GO:0000991)
0.1 0.2 GO:0003680 AT DNA binding(GO:0003680)
0.1 0.2 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.1 1.1 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 2.8 GO:0008289 lipid binding(GO:0008289)
0.1 0.5 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.1 0.6 GO:0015179 L-amino acid transmembrane transporter activity(GO:0015179)
0.1 0.3 GO:0004864 protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
0.0 0.1 GO:0004629 phospholipase C activity(GO:0004629)
0.0 0.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.2 GO:0001167 RNA polymerase I transcription factor activity, sequence-specific DNA binding(GO:0001167)
0.0 0.1 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.9 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.4 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.2 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 0.2 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.0 0.5 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0 1.1 GO:0042393 histone binding(GO:0042393)
0.0 0.3 GO:0031386 protein tag(GO:0031386)
0.0 0.1 GO:0001083 transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083)
0.0 0.1 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.1 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 0.3 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.0 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.0 0.1 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.0 0.3 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 0.2 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 0.3 GO:0003779 actin binding(GO:0003779)
0.0 0.1 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.4 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.5 GO:0003682 chromatin binding(GO:0003682)
0.0 0.4 GO:0030695 GTPase regulator activity(GO:0030695)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 PID SHP2 PATHWAY SHP2 signaling
1.0 2.9 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.3 3.4 PID ATR PATHWAY ATR signaling pathway
0.3 1.3 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.3 0.3 PID NOTCH PATHWAY Notch signaling pathway
0.3 0.3 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.2 0.7 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.2 0.4 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.2 0.5 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.1 0.5 PID P73PATHWAY p73 transcription factor network
0.1 0.4 NABA CORE MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.1 0.2 PID E2F PATHWAY E2F transcription factor network
0.0 0.2 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.1 PID ATM PATHWAY ATM pathway
0.0 0.1 PID MYC PATHWAY C-MYC pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 29.7 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
1.8 7.1 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
1.8 28.2 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
1.5 4.4 REACTOME SIGNALLING TO ERKS Genes involved in Signalling to ERKs
1.2 2.5 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
1.0 7.0 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.8 3.3 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.7 2.9 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.7 1.4 REACTOME DNA STRAND ELONGATION Genes involved in DNA strand elongation
0.7 2.1 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.7 0.7 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.6 1.8 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.3 1.7 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.3 1.3 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.3 0.3 REACTOME SIGNALING BY THE B CELL RECEPTOR BCR Genes involved in Signaling by the B Cell Receptor (BCR)
0.3 1.6 REACTOME TRANSLATION Genes involved in Translation
0.2 0.8 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.2 0.6 REACTOME DEVELOPMENTAL BIOLOGY Genes involved in Developmental Biology
0.2 0.7 REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION Genes involved in Platelet activation, signaling and aggregation
0.1 0.1 REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.1 0.3 REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM Genes involved in Cytokine Signaling in Immune system
0.1 0.3 REACTOME GPCR DOWNSTREAM SIGNALING Genes involved in GPCR downstream signaling
0.1 0.6 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1 0.6 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 1.1 REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS Genes involved in Metabolism of lipids and lipoproteins
0.1 0.2 REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA Genes involved in Processing of Capped Intron-Containing Pre-mRNA
0.0 0.4 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.0 0.1 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.2 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.2 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.0 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.1 REACTOME RNA POL II TRANSCRIPTION Genes involved in RNA Polymerase II Transcription