Results for ECM23
Z-value: 0.72
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Transcription factors associated with ECM23
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
ECM23
|
S000005942 | Non-essential protein of unconfirmed function |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YFR055W Show fit | 9.78 |
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner |
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| YFR056C Show fit | 8.88 |
Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W |
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| YJR094W-A Show fit | 6.89 |
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein |
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| YOR315W Show fit | 6.60 |
Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate |
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| YLR413W Show fit | 5.55 |
Putative protein of unknown function; YLR413W is not an essential gene |
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| YGR108W Show fit | 5.01 |
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome |
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| YIR021W Show fit | 4.49 |
Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA |
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| YPR119W Show fit | 4.26 |
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome |
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| YKL218C Show fit | 4.00 |
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate |
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| YGL179C Show fit | 3.89 |
Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome |
Network of associatons between targets according to the STRING database.
First level regulatory network of ECM23
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 49.5 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.8 | 13.7 | GO:0051029 | rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029) |
| 3.3 | 9.8 | GO:0000098 | sulfur amino acid catabolic process(GO:0000098) |
| 1.3 | 9.4 | GO:0010696 | positive regulation of spindle pole body separation(GO:0010696) |
| 0.3 | 8.6 | GO:0016126 | steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126) |
| 0.1 | 8.0 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 0.2 | 6.5 | GO:0009303 | rRNA transcription(GO:0009303) |
| 0.1 | 6.1 | GO:0007124 | pseudohyphal growth(GO:0007124) |
| 0.1 | 6.0 | GO:0006364 | rRNA processing(GO:0006364) |
| 0.3 | 5.9 | GO:0002097 | tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 36.7 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.4 | 24.5 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 14.4 | GO:0005933 | cellular bud(GO:0005933) |
| 0.1 | 10.0 | GO:0005730 | nucleolus(GO:0005730) |
| 0.1 | 9.7 | GO:0005576 | extracellular region(GO:0005576) |
| 0.4 | 7.1 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.2 | 6.1 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.3 | 4.5 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.3 | 4.4 | GO:0022626 | cytosolic ribosome(GO:0022626) |
| 0.0 | 4.3 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 46.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.3 | 14.5 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.4 | 11.5 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 1.6 | 9.7 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.1 | 7.5 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.3 | 6.3 | GO:0015926 | glucosidase activity(GO:0015926) |
| 0.2 | 4.8 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.3 | 4.5 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 0.2 | 4.4 | GO:0042162 | telomeric DNA binding(GO:0042162) |
| 0.1 | 4.1 | GO:0003743 | translation initiation factor activity(GO:0003743) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.5 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.3 | 1.5 | PID FGF PATHWAY | FGF signaling pathway |
| 0.3 | 1.2 | PID E2F PATHWAY | E2F transcription factor network |
| 0.2 | 1.1 | PID P73PATHWAY | p73 transcription factor network |
| 0.1 | 1.1 | PID ATR PATHWAY | ATR signaling pathway |
| 0.5 | 0.5 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.2 | 0.5 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.2 | 0.5 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 0.4 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 0.4 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 6.5 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 0.5 | 4.0 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.4 | 2.3 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.4 | 1.3 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.2 | 1.3 | REACTOME GPCR DOWNSTREAM SIGNALING | Genes involved in GPCR downstream signaling |
| 0.3 | 1.1 | REACTOME NUCLEOTIDE EXCISION REPAIR | Genes involved in Nucleotide Excision Repair |
| 0.3 | 1.0 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.2 | 1.0 | REACTOME REGULATION OF MITOTIC CELL CYCLE | Genes involved in Regulation of mitotic cell cycle |
| 0.1 | 1.0 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.4 | 0.8 | REACTOME G1 PHASE | Genes involved in G1 Phase |