Results for ECM22
Z-value: 1.73
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Transcription factors associated with ECM22
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
ECM22
|
S000004218 | Sterol regulatory element binding protein |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YGR067C Show fit | 20.18 |
Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p |
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| YNL117W Show fit | 19.89 |
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium |
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| YKR097W Show fit | 17.05 |
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol |
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| YAR035W Show fit | 15.65 |
Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated |
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| YKL217W Show fit | 13.85 |
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose |
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| YOR348C Show fit | 13.38 |
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells |
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| YPL223C Show fit | 13.36 |
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway |
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| YLR377C Show fit | 12.95 |
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism |
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| YLR307C-A Show fit | 12.75 |
Putative protein of unknown function |
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| YHR096C Show fit | 11.45 |
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs |
Network of associatons between targets according to the STRING database.
First level regulatory network of ECM22
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 36.8 | GO:0006094 | gluconeogenesis(GO:0006094) |
| 3.1 | 27.5 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 8.6 | 25.9 | GO:0009437 | amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437) |
| 1.4 | 21.0 | GO:0006099 | tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101) |
| 2.0 | 19.8 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 1.0 | 14.5 | GO:0000436 | carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436) |
| 3.5 | 13.9 | GO:0006848 | pyruvate transport(GO:0006848) |
| 3.2 | 12.8 | GO:0015804 | neutral amino acid transport(GO:0015804) |
| 0.9 | 10.1 | GO:0015758 | glucose transport(GO:0015758) |
| 2.5 | 9.9 | GO:0015847 | putrescine transport(GO:0015847) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 21.6 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 19.5 | GO:0005886 | plasma membrane(GO:0005886) |
| 1.6 | 19.4 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.3 | 14.7 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 2.1 | 12.7 | GO:0045239 | tricarboxylic acid cycle enzyme complex(GO:0045239) |
| 1.3 | 11.3 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 1.6 | 11.2 | GO:0034657 | GID complex(GO:0034657) |
| 2.7 | 11.0 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.1 | 11.0 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 10.9 | GO:0098852 | fungal-type vacuole membrane(GO:0000329) lytic vacuole membrane(GO:0098852) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.9 | 34.3 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 8.6 | 25.9 | GO:0004092 | carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406) |
| 1.9 | 20.8 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 0.9 | 19.0 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 3.6 | 14.2 | GO:0015193 | L-proline transmembrane transporter activity(GO:0015193) |
| 2.6 | 13.0 | GO:0050308 | sugar-phosphatase activity(GO:0050308) |
| 0.6 | 11.0 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.4 | 10.0 | GO:0016836 | hydro-lyase activity(GO:0016836) |
| 0.4 | 9.8 | GO:0061733 | histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733) |
| 1.1 | 8.5 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 50.8 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 5.7 | 17.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 1.0 | 5.8 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.4 | 3.8 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.7 | 2.0 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.2 | 0.7 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 0.4 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.1 | 0.2 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.1 | 0.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 0.1 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 50.8 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 3.4 | 30.4 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 2.8 | 8.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 1.5 | 5.8 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 1.3 | 3.8 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.4 | 3.5 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.2 | 0.7 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.1 | 0.7 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.1 | 0.4 | REACTOME HEMOSTASIS | Genes involved in Hemostasis |
| 0.1 | 0.3 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |