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Results for ECM22

Z-value: 1.73

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Transcription factors associated with ECM22

Gene Symbol Gene ID Gene Info
ECM22
S000004218 Sterol regulatory element binding protein

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ECM22YLR228C0.906.8e-10Click!

Activity profile of ECM22 motif

Sorted Z-values of ECM22 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YGR067C 20.18 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YNL117W 19.89
MLS1
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YKR097W 17.05
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YAR035W 15.65
YAT1
Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
YKL217W 13.85
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YOR348C 13.38
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YPL223C 13.36
GRE1
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YLR377C 12.95
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YLR307C-A 12.75 Putative protein of unknown function
YHR096C 11.45
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YKL109W 10.95
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YDR536W 10.53
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YER024W 10.29
YAT2
Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane
YDL210W 9.93
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YPR036W-A 9.56 Protein of unknown function; transcription is regulated by Pdr1p
YPL262W 9.12
FUM1
Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation; phosphorylated in mitochondria
YBR105C 8.90
VID24
Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; involved in proteasome-dependent catabolite degradation of FBPase
YOR382W 8.89
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YJR048W 8.50
CYC1
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YMR206W 8.33 Putative protein of unknown function; YMR206W is not an essential gene
YAR053W 8.13 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL144C 7.95 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YPL054W 7.90
LEE1
Zinc-finger protein of unknown function
YLR312C 7.57
QNQ1
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YIL057C 7.11 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YPR030W 7.10
CSR2
Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate
YLR142W 6.87
PUT1
Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
YDL085W 6.65
NDE2
Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
YBL043W 6.61
ECM13
Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YKL141W 6.42
SDH3
Cytochrome b subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YLR174W 6.03
IDP2
Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
YBR051W 6.00 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase
YEL049W 5.90
PAU2
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YAR060C 5.85 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR050C 5.82
REG2
Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
YPL134C 5.81
ODC1
Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation
YOR343C 5.78 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YPL222W 5.73
FMP40
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOL060C 5.51
MAM3
Protein required for normal mitochondrial morphology, has similarity to hemolysins
YNL142W 5.48
MEP2
Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YNL194C 5.41 Integral membrane protein localized to eisosomes; sporulation and plasma membrane sphingolipid content are altered in mutants; has homologs SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YER084W 5.27 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL156C 5.09
PRM4
Pheromone-regulated protein, predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift
YPR006C 4.98
ICL2
2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol
YNL180C 4.92
RHO5
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
YPR150W 4.91 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C
YFL024C 4.85
EPL1
Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb
YMR081C 4.84
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YBR230C 4.79
OM14
Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron
YER088C 4.76
DOT6
Protein of unknown function, involved in telomeric gene silencing and filamentation
YPR023C 4.68
EAF3
Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition
YFL030W 4.68
AGX1
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YPR061C 4.68
JID1
Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
YLR304C 4.63
ACO1
Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy
YNL179C 4.55 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
YEL012W 4.51
UBC8
Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
YDR529C 4.50
QCR7
Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly
YOR139C 4.30 Hypothetical protein
YER015W 4.27
FAA2
Long chain fatty acyl-CoA synthetase; accepts a wider range of acyl chain lengths than Faa1p, preferring C9:0-C13:0; involved in the activation of endogenous pools of fatty acids
YAL039C 4.25
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YPL229W 4.07 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL229W is not an essential gene
YBL015W 4.00
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YOR140W 3.93
SFL1
Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p
YDR036C 3.85
EHD3
3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis
YCL057C-A 3.82 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPR007C 3.81
REC8
Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p
YIL136W 3.78
OM45
Protein of unknown function, major constituent of the mitochondrial outer membrane; located on the outer (cytosolic) face of the outer membrane
YOR374W 3.78
ALD4
Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
YMR304W 3.73
UBP15
Ubiquitin-specific protease that may play a role in ubiquitin precursor processing
YNL143C 3.70 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR262W 3.69 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment
YPL024W 3.65
RMI1
Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YIL125W 3.63
KGD1
Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA
YHR212C 3.56 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR061W 3.50 Putative protein of unknown function; non-essential gene with similarity to Mnn4, a putative membrane protein involved in glycosylation; transcription repressed by Rm101p
YBL078C 3.49
ATG8
Conserved protein that is a component of autophagosomes and Cvt vesicles; undergoes C-terminal conjugation to phosphatidylethanolamine (PE), Atg8p-PE is anchored to membranes and may mediate membrane fusion during autophagosome formation
YBR280C 3.45
SAF1
F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1
YCR010C 3.39
ADY2
Acetate transporter required for normal sporulation; phosphorylated in mitochondria
YDR343C 3.21
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YHR212W-A 3.21 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YPL026C 3.21
SKS1
Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YGL183C 3.20
MND1
Protein required for recombination and meiotic nuclear division; forms a complex with Hop2p, which is involved in chromosome pairing and repair of meiotic double-strand breaks
YNL305C 3.16 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL305C is not an essential gene
YLR296W 3.12 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR055W 3.06
PST1
Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1
YEL008W 3.03 Hypothetical protein predicted to be involved in metabolism
YEL009C 2.98
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YDR275W 2.88
BSC2
Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
YJL152W 2.85 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR065W 2.84
CYT1
Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
YOR072W 2.83 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YMR182C 2.80
RGM1
Putative transcriptional repressor with proline-rich zinc fingers; overproduction impairs cell growth
YJR046W 2.75
TAH11
DNA replication licensing factor, required for pre-replication complex assembly
YDL215C 2.70
GDH2
NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels
YDR009W 2.69
GAL3
Transcriptional regulator involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity
YGR258C 2.66
RAD2
Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
YDR216W 2.64
ADR1
Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
YPL058C 2.62
PDR12
Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity
YLR295C 2.61
ATP14
Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YDL140C 2.58
RPO21
RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
YJR045C 2.58
SSC1
Mitochondrial matrix ATPase, subunit of the presequence translocase-associated protein import motor (PAM) and of SceI endonuclease; involved in protein folding and translocation into the matrix; phosphorylated; member of HSP70 family
YOR138C 2.57
RUP1
Protein involved in regulation of Rsp5p, which is an essential HECT ubiquitin ligase; required for binding of Rsp5p to Ubp2p; contains an UBA domain
YOL147C 2.54
PEX11
Peroxisomal membrane protein required for peroxisome proliferation and medium-chain fatty acid oxidation, most abundant protein in the peroxisomal membrane, regulated by Adr1p and Pip2p-Oaf1p, promoter contains ORE and UAS1-like elements
YGL192W 2.49
IME4
Probable mRNA N6-adenosine methyltransferase that is required for IME1 transcript accumulation and for sporulation; expression is induced in starved MATa/MAT alpha diploid cells
YGL193C 2.46 Haploid-specific gene repressed by a1-alpha2, turned off in sir3 null strains, absence enhances the sensitivity of rad52-327 cells to campothecin almost 100-fold
YHR015W 2.45
MIP6
Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export
YOR071C 2.43
NRT1
High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
YKL046C 2.41
DCW1
Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p
YGL134W 2.38
PCL10
Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate
YMR135C 2.27
GID8
Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START
YNL105W 2.24 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene INP52
YMR271C 2.24
URA10
Minor orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; major OPRTase encoded by URA5
YEL050C 2.22
RML2
Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor
YLR324W 2.21
PEX30
Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p
YGL006W 2.21
PMC1
Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a
YHR001W-A 2.19
QCR10
Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain
YOR072W-A 2.17 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR072W; originally identified by fungal homology and RT-PCR
YMR165C 2.09
PAH1
Mg2+-dependent phosphatidate (PA) phosphatase, catalyzes the dephosphorylation of PA to yield diacylglycerol and Pi, responsible for de novo lipid synthesis; homologous to mammalian lipin 1
YER014C-A 2.07
BUD25
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YNL274C 2.07
GOR1
Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YCL025C 2.05
AGP1
Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)
YKL086W 2.04
SRX1
Sulfiredoxin, contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxins Tsa1p and Ahp1p that are formed upon exposure to oxidants; conserved in higher eukaryotes
YBR230W-A 1.98 Putative protein of unknown function
YEL060C 1.98
PRB1
Vacuolar proteinase B (yscB), a serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation
YER033C 1.95
ZRG8
Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency
YBL030C 1.86
PET9
Major ADP/ATP carrier of the mitochondrial inner membrane, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; required for viability in many common lab strains carrying a mutation in the polymorphic SAL1 gene
YDR490C 1.86
PKH1
Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p
YPR015C 1.84 Putative protein of unknown function
YLR184W 1.81 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFR053C 1.79
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YEL024W 1.77
RIP1
Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration
YMR251W 1.75
GTO3
Omega class glutathione transferase; putative cytosolic localization
YOR383C 1.74
FIT3
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YIL162W 1.74
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YPR024W 1.74
YME1
Subunit, with Mgr1p, of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; mutation causes an elevated rate of mitochondrial turnover
YDL181W 1.70
INH1
Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has similarity to Stf1p; has a calmodulin-binding motif and binds calmodulin in vitro
YLL051C 1.69
FRE6
Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels
YOL055C 1.66
THI20
Multifunctional protein with both hydroxymethylpyrimidine kinase and thiaminase activities; involved in thiamine biosynthesis and also in thiamine degradation; member of a gene family with THI21 and THI22; functionally redundant with Thi21p
YOR371C 1.66
GPB1
Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb2p
YBR035C 1.65
PDX3
Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism
YDR258C 1.63
HSP78
Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; prevents the aggregation of misfolded matrix proteins; component of the mitochondrial proteolysis system
YNL277W-A 1.57 Putative protein of unknown function
YLR122C 1.56 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YER065C 1.54
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YOL037C 1.54 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W
YML025C 1.53
YML6
Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
YCR007C 1.52 Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YDR070C 1.51
FMP16
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBR056W-A 1.49 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR056C-B
YGL096W 1.49
TOS8
Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p
YGR087C 1.49
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YOL036W 1.46 Protein of unknown function; potential Cdc28p substrate
YFR016C 1.43 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene
YPR151C 1.42
SUE1
Mitochondrial protein required for degradation of unstable forms of cytochrome c
YGL163C 1.42
RAD54
DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family
YMR068W 1.42
AVO2
Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
YJL093C 1.37
TOK1
Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin
YML100W 1.34
TSL1
Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose, homologous to Tps3p and may share function
YLR297W 1.34 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YLR297W is not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation
YDR034C 1.34
LYS14
Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
YLR123C 1.32 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YPL015C 1.30
HST2
Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro
YOR338W 1.27 Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen
YMR145C 1.25
NDE1
Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain
YJL121C 1.25
RPE1
D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress
YJR052W 1.23
RAD7
Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
YNL106C 1.21
INP52
Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
YLR213C 1.19
CRR1
Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
YIL077C 1.16 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YDL214C 1.15
PRR2
Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
YDL079C 1.14
MRK1
Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation
YJR148W 1.13
BAT2
Cytosolic branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase
YBR269C 1.11
FMP21
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YEL007W 1.11 Putative protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1)
YPR160W 1.10
GPH1
Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
YGL194C 1.09
HOS2
Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity
YHR048W 1.09
YHK8
Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
YFL023W 1.08
BUD27
Protein involved in bud-site selection, nutrient signaling, and gene expression controlled by TOR kinase; diploid mutants show a random budding pattern rather than the wild-type bipolar pattern; plays a role in regulating Ty1 transposition
YOR068C 1.08
VAM10
Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering
YPL025C 1.08 Hypothetical protein
YJL119C 1.07 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR538W 1.07
PAD1
Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; homolog of E. coli UbiX
YLL019C 1.07
KNS1
Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues
YPR065W 1.04
ROX1
Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity
YNL125C 1.04
ESBP6
Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
YFL054C 1.02 Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol
YLR308W 1.01
CDA2
Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
YGR101W 1.00
PCP1
Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases
YPR009W 0.99
SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p
YGR023W 0.97
MTL1
Protein with both structural and functional similarity to Mid2p, which is a plasma membrane sensor required for cell integrity signaling during pheromone-induced morphogenesis; suppresses rgd1 null mutations
YHR095W 0.97 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR139C 0.97
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YDL010W 0.97
GRX6
Cis-golgi localized monothiol glutaredoxin that binds an iron-sulfur cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; functional overlap with GRX6
YNL034W 0.95 Putative protein of unknown function; YNL034W is not an essential gene
YGR260W 0.95
TNA1
High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)
YDL011C 0.95 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W
YGR022C 0.95 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
YNL335W 0.94
DDI3
Hypothetical protein
YGL089C 0.93
MF(ALPHA)2
Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2
YJR151C 0.92
DAN4
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth

Network of associatons between targets according to the STRING database.

First level regulatory network of ECM22

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
8.6 25.9 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
3.5 13.9 GO:0006848 pyruvate transport(GO:0006848)
3.2 12.8 GO:0015804 neutral amino acid transport(GO:0015804)
3.1 27.5 GO:0006097 glyoxylate cycle(GO:0006097)
3.0 8.9 GO:0051469 vesicle fusion with vacuole(GO:0051469)
2.5 9.9 GO:0015847 putrescine transport(GO:0015847)
2.3 6.9 GO:0010133 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
2.1 2.1 GO:0046487 glyoxylate metabolic process(GO:0046487)
2.0 19.8 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
2.0 9.8 GO:0015793 glycerol transport(GO:0015793)
1.8 5.5 GO:0072488 ammonium transmembrane transport(GO:0072488)
1.7 5.0 GO:0019626 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
1.6 4.8 GO:0006545 glycine biosynthetic process(GO:0006545)
1.6 6.3 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
1.6 4.7 GO:0017003 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
1.6 4.7 GO:0006740 NADPH regeneration(GO:0006740)
1.5 4.6 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
1.4 4.2 GO:0043335 protein unfolding(GO:0043335)
1.4 21.0 GO:0006099 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101)
1.3 2.6 GO:0034310 ethanol catabolic process(GO:0006068) primary alcohol catabolic process(GO:0034310)
1.3 36.8 GO:0006094 gluconeogenesis(GO:0006094)
1.2 9.7 GO:0015891 siderophore transport(GO:0015891)
1.2 4.7 GO:0009300 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
1.1 7.9 GO:0019660 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
1.0 4.0 GO:0006083 acetate metabolic process(GO:0006083)
1.0 14.5 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.9 10.1 GO:0015758 glucose transport(GO:0015758)
0.9 3.7 GO:0043388 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
0.8 6.5 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.8 2.4 GO:0015888 thiamine transport(GO:0015888)
0.8 7.1 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.8 5.5 GO:0030026 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.8 5.5 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.7 3.0 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.7 1.3 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.6 2.4 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.6 1.7 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.6 1.7 GO:0051238 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.6 2.2 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.5 3.2 GO:0034762 regulation of transmembrane transport(GO:0034762)
0.5 2.7 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.5 2.1 GO:0034389 lipid particle organization(GO:0034389)
0.5 2.4 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
0.5 3.8 GO:0051177 meiotic sister chromatid cohesion(GO:0051177)
0.5 1.4 GO:0032077 positive regulation of deoxyribonuclease activity(GO:0032077) positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.5 1.9 GO:0015886 ATP transport(GO:0015867) heme transport(GO:0015886)
0.4 2.6 GO:0042407 cristae formation(GO:0042407)
0.4 1.3 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.4 1.7 GO:0009229 thiamine diphosphate biosynthetic process(GO:0009229) thiamine diphosphate metabolic process(GO:0042357)
0.4 2.0 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.4 1.1 GO:0032874 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.4 1.8 GO:0071333 cellular glucose homeostasis(GO:0001678) carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255) carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.4 2.9 GO:0016559 peroxisome fission(GO:0016559)
0.4 1.1 GO:0019748 secondary metabolic process(GO:0019748)
0.3 1.7 GO:0005987 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.3 6.7 GO:0016579 protein deubiquitination(GO:0016579)
0.3 1.3 GO:2000284 positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.3 1.2 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.3 0.6 GO:0006538 glutamate catabolic process(GO:0006538)
0.3 0.9 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.3 0.9 GO:0042743 hydrogen peroxide metabolic process(GO:0042743) hydrogen peroxide catabolic process(GO:0042744)
0.3 0.9 GO:0046466 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.3 1.2 GO:0043901 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.3 1.6 GO:0042823 pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823) aldehyde biosynthetic process(GO:0046184)
0.3 3.6 GO:0019740 nitrogen utilization(GO:0019740)
0.3 3.5 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.2 2.0 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.2 1.1 GO:0005980 glycogen catabolic process(GO:0005980)
0.2 0.6 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.2 1.2 GO:0006465 signal peptide processing(GO:0006465)
0.2 1.0 GO:1901072 aminoglycan catabolic process(GO:0006026) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.2 5.3 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.2 0.2 GO:0032071 regulation of deoxyribonuclease activity(GO:0032070) regulation of endodeoxyribonuclease activity(GO:0032071)
0.2 2.5 GO:1905037 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.2 0.5 GO:0019401 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.2 0.7 GO:0031507 heterochromatin assembly(GO:0031507)
0.2 0.6 GO:0019563 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.2 3.4 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 1.1 GO:0000103 sulfate assimilation(GO:0000103)
0.1 0.4 GO:0090155 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.1 1.1 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 1.2 GO:0022904 respiratory electron transport chain(GO:0022904) ATP synthesis coupled electron transport(GO:0042773) mitochondrial ATP synthesis coupled electron transport(GO:0042775)
0.1 4.6 GO:0009060 aerobic respiration(GO:0009060)
0.1 1.6 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.1 0.6 GO:0043605 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256) cellular amide catabolic process(GO:0043605)
0.1 0.3 GO:0008105 asymmetric protein localization(GO:0008105)
0.1 0.8 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 1.6 GO:0046854 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.1 0.4 GO:0006827 high-affinity iron ion transmembrane transport(GO:0006827)
0.1 1.9 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 0.2 GO:0042148 strand invasion(GO:0042148)
0.1 0.5 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.1 0.5 GO:0034354 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.1 0.9 GO:0031167 rRNA methylation(GO:0031167)
0.1 0.6 GO:0015677 copper ion import(GO:0015677)
0.1 5.5 GO:0006839 mitochondrial transport(GO:0006839)
0.1 0.4 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 0.8 GO:0046686 response to cadmium ion(GO:0046686)
0.1 0.3 GO:0051180 vitamin transport(GO:0051180)
0.1 0.4 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.1 1.0 GO:0051181 cofactor transport(GO:0051181)
0.1 0.5 GO:0009231 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.1 2.9 GO:0000282 cellular bud site selection(GO:0000282) mitotic cytokinesis, site selection(GO:1902408)
0.1 0.2 GO:0099515 actin filament-based movement(GO:0030048) actin filament-based transport(GO:0099515)
0.1 0.3 GO:0051303 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.1 0.1 GO:0090180 regulation of vitamin metabolic process(GO:0030656) positive regulation of vitamin metabolic process(GO:0046136) positive regulation of sulfur metabolic process(GO:0051176) regulation of thiamine biosynthetic process(GO:0070623) positive regulation of thiamine biosynthetic process(GO:0090180)
0.1 0.3 GO:0001301 progressive alteration of chromatin involved in cell aging(GO:0001301) progressive alteration of chromatin involved in replicative cell aging(GO:0001304) negative regulation of chromatin silencing involved in replicative cell aging(GO:0001308)
0.1 0.3 GO:0015809 arginine transport(GO:0015809)
0.1 0.6 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.1 0.5 GO:0006829 zinc II ion transport(GO:0006829)
0.1 0.4 GO:0034501 protein localization to kinetochore(GO:0034501)
0.1 0.3 GO:0043112 receptor recycling(GO:0001881) protein import into peroxisome matrix, receptor recycling(GO:0016562) receptor metabolic process(GO:0043112)
0.1 0.6 GO:0000132 establishment of mitotic spindle orientation(GO:0000132) establishment of mitotic spindle localization(GO:0040001) establishment of spindle orientation(GO:0051294)
0.1 2.9 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.1 0.7 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.1 0.2 GO:0031297 replication fork processing(GO:0031297)
0.1 0.8 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.1 3.9 GO:0031505 fungal-type cell wall organization(GO:0031505)
0.1 0.3 GO:0006078 (1->6)-beta-D-glucan biosynthetic process(GO:0006078)
0.1 1.9 GO:0042244 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
0.1 0.7 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.0 0.5 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.0 0.1 GO:0010511 regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.0 0.2 GO:0070550 rDNA condensation(GO:0070550)
0.0 1.1 GO:0042144 vacuole fusion, non-autophagic(GO:0042144)
0.0 0.4 GO:0007006 mitochondrial membrane organization(GO:0007006)
0.0 0.2 GO:0000755 cytogamy(GO:0000755)
0.0 0.4 GO:0000742 karyogamy involved in conjugation with cellular fusion(GO:0000742)
0.0 0.5 GO:0007533 mating type switching(GO:0007533)
0.0 0.3 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.6 GO:0007031 peroxisome organization(GO:0007031)
0.0 0.2 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.0 0.1 GO:0010388 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.0 0.0 GO:0070726 cell wall assembly(GO:0070726)
0.0 1.2 GO:0006413 translational initiation(GO:0006413)
0.0 0.1 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.0 1.0 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0 0.1 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.1 GO:2001023 cellular response to drug(GO:0035690) regulation of response to drug(GO:2001023) positive regulation of response to drug(GO:2001025) regulation of cellular response to drug(GO:2001038) positive regulation of cellular response to drug(GO:2001040)
0.0 0.3 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.1 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491) snRNA pseudouridine synthesis(GO:0031120) snRNA modification(GO:0040031)
0.0 0.1 GO:0009312 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.0 0.0 GO:0043954 cellular component maintenance(GO:0043954)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 11.0 GO:0016602 CCAAT-binding factor complex(GO:0016602)
2.1 12.7 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
1.6 19.4 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
1.6 11.2 GO:0034657 GID complex(GO:0034657)
1.3 10.5 GO:0042597 periplasmic space(GO:0042597)
1.3 6.4 GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) mitochondrial inner membrane protein insertion complex(GO:0042721) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
1.3 11.3 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
1.2 3.7 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.9 4.7 GO:0032221 Rpd3S complex(GO:0032221)
0.9 2.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.8 4.8 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.7 6.0 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.7 9.4 GO:0070469 respiratory chain(GO:0070469)
0.5 9.6 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.5 2.6 GO:0072379 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.4 4.2 GO:0033698 Rpd3L complex(GO:0033698)
0.4 8.7 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.4 1.2 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.4 2.7 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.3 1.0 GO:0044426 cell wall part(GO:0044426) external encapsulating structure part(GO:0044462)
0.3 14.7 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.3 1.0 GO:0005796 Golgi lumen(GO:0005796)
0.3 2.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.3 3.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 1.5 GO:0032126 eisosome(GO:0032126)
0.2 1.4 GO:0031932 TORC2 complex(GO:0031932)
0.2 3.2 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.2 9.7 GO:0031225 anchored component of membrane(GO:0031225)
0.2 1.9 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.2 1.1 GO:0034967 Set3 complex(GO:0034967)
0.2 1.1 GO:0016272 prefoldin complex(GO:0016272)
0.2 21.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 0.7 GO:0070775 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.1 3.7 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 5.4 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 0.6 GO:0005869 dynactin complex(GO:0005869)
0.1 1.5 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 2.0 GO:0005656 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.1 0.4 GO:0033186 CAF-1 complex(GO:0033186)
0.1 0.7 GO:0035097 histone methyltransferase complex(GO:0035097) Set1C/COMPASS complex(GO:0048188)
0.1 1.8 GO:0031201 SNARE complex(GO:0031201)
0.1 10.9 GO:0098852 fungal-type vacuole membrane(GO:0000329) lytic vacuole membrane(GO:0098852)
0.1 7.1 GO:0005740 mitochondrial envelope(GO:0005740)
0.1 0.4 GO:0031262 Ndc80 complex(GO:0031262)
0.1 11.0 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 0.4 GO:0035339 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.1 1.8 GO:0019898 extrinsic component of membrane(GO:0019898)
0.1 1.9 GO:0005576 extracellular region(GO:0005576)
0.1 0.2 GO:0030870 Mre11 complex(GO:0030870)
0.1 19.5 GO:0005886 plasma membrane(GO:0005886)
0.1 0.2 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.0 0.7 GO:0000812 Swr1 complex(GO:0000812)
0.0 3.3 GO:0043332 mating projection tip(GO:0043332)
0.0 0.1 GO:0070209 ASTRA complex(GO:0070209)
0.0 0.2 GO:0000799 condensin complex(GO:0000796) nuclear condensin complex(GO:0000799)
0.0 0.1 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.5 GO:0000324 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.0 0.2 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.1 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.8 GO:0005643 nuclear pore(GO:0005643)
0.0 0.2 GO:0071012 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.0 0.1 GO:0043614 multi-eIF complex(GO:0043614)
0.0 0.1 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.0 0.4 GO:0000151 ubiquitin ligase complex(GO:0000151)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
8.6 25.9 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
6.9 34.3 GO:0015295 solute:proton symporter activity(GO:0015295)
3.6 14.2 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
2.6 7.9 GO:0008137 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
2.6 7.9 GO:0016289 CoA hydrolase activity(GO:0016289)
2.6 13.0 GO:0050308 sugar-phosphatase activity(GO:0050308)
2.1 6.4 GO:0048038 quinone binding(GO:0048038)
2.0 6.0 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
1.9 20.8 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
1.8 3.6 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
1.4 4.3 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
1.1 6.5 GO:0016833 oxo-acid-lyase activity(GO:0016833)
1.1 8.5 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.9 19.0 GO:0016831 carboxy-lyase activity(GO:0016831)
0.8 5.0 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.8 3.3 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.6 5.8 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.6 11.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.6 3.7 GO:0000400 four-way junction DNA binding(GO:0000400)
0.6 1.7 GO:0004564 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
0.6 7.4 GO:0044389 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.6 2.2 GO:0015085 calcium ion transmembrane transporter activity(GO:0015085)
0.6 1.7 GO:0008972 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.6 1.7 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.5 2.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.5 6.9 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors(GO:0016645)
0.5 5.8 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.5 2.4 GO:0004559 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.5 1.9 GO:0004396 hexokinase activity(GO:0004396)
0.5 1.9 GO:0005471 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
0.4 10.0 GO:0016836 hydro-lyase activity(GO:0016836)
0.4 1.6 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.4 1.2 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity(GO:0034596) phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.4 3.5 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.4 2.7 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.4 9.8 GO:0061733 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.4 3.5 GO:0031386 protein tag(GO:0031386)
0.3 2.4 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.3 4.8 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.3 1.4 GO:0005261 cation channel activity(GO:0005261)
0.3 4.0 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.3 1.6 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.3 5.5 GO:0046906 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.3 5.5 GO:0008483 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.3 2.4 GO:0017136 NAD-dependent histone deacetylase activity(GO:0017136) NAD-dependent protein deacetylase activity(GO:0034979)
0.3 3.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.3 0.9 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825)
0.3 2.6 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.3 2.9 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.3 1.8 GO:0004364 glutathione transferase activity(GO:0004364)
0.2 1.0 GO:0015038 glutathione-disulfide reductase activity(GO:0004362) peptide disulfide oxidoreductase activity(GO:0015037) glutathione disulfide oxidoreductase activity(GO:0015038)
0.2 0.9 GO:0000772 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.2 0.9 GO:0005537 mannose binding(GO:0005537)
0.2 0.9 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.2 0.6 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.2 3.9 GO:0004843 obsolete ubiquitin thiolesterase activity(GO:0004221) thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.2 0.5 GO:0032183 SUMO binding(GO:0032183)
0.2 1.5 GO:0001055 RNA polymerase II activity(GO:0001055)
0.2 0.5 GO:0004457 lactate dehydrogenase activity(GO:0004457) D-lactate dehydrogenase (cytochrome) activity(GO:0004458) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
0.2 1.6 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.2 3.7 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 2.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.1 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.1 0.4 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.1 0.5 GO:0016531 copper chaperone activity(GO:0016531)
0.1 1.0 GO:0051184 cofactor transporter activity(GO:0051184)
0.1 0.4 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.1 0.5 GO:0019238 cyclohydrolase activity(GO:0019238)
0.1 0.9 GO:0000149 SNARE binding(GO:0000149)
0.1 0.7 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 0.8 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.1 0.3 GO:0051183 vitamin transporter activity(GO:0051183)
0.1 0.9 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 1.7 GO:0004857 enzyme inhibitor activity(GO:0004857)
0.1 0.2 GO:0005102 receptor binding(GO:0005102)
0.1 1.2 GO:0015616 DNA translocase activity(GO:0015616)
0.1 4.7 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 0.2 GO:0070336 flap-structured DNA binding(GO:0070336)
0.1 0.2 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
0.1 1.5 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.1 0.2 GO:0003691 double-stranded telomeric DNA binding(GO:0003691) G-quadruplex DNA binding(GO:0051880)
0.1 0.6 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.1 0.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.3 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 1.2 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 1.9 GO:0042626 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 0.1 GO:0004180 carboxypeptidase activity(GO:0004180)
0.0 0.9 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.5 GO:0005353 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.0 0.2 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.0 0.4 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.8 GO:0008094 DNA-dependent ATPase activity(GO:0008094)
0.0 1.0 GO:0008173 RNA methyltransferase activity(GO:0008173)
0.0 0.1 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 0.8 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.0 0.2 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.7 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.0 0.3 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.2 GO:0010181 FMN binding(GO:0010181)
0.0 0.5 GO:0003678 DNA helicase activity(GO:0003678)
0.0 0.4 GO:0008374 O-acyltransferase activity(GO:0008374)
0.0 0.2 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.0 0.1 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.4 GO:0042393 histone binding(GO:0042393)
0.0 0.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.2 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.9 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.1 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.2 GO:0016298 lipase activity(GO:0016298)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
5.7 17.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
1.0 5.8 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.7 2.0 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.4 3.8 PID FANCONI PATHWAY Fanconi anemia pathway
0.2 0.7 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 0.4 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.1 0.2 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.1 0.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 50.8 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 0.1 PID CASPASE PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 30.4 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
2.8 8.5 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
1.5 5.8 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
1.3 3.8 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.4 3.5 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.2 0.7 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 0.4 REACTOME HEMOSTASIS Genes involved in Hemostasis
0.1 0.7 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.1 0.3 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.2 REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES Genes involved in Transmembrane transport of small molecules
0.0 50.8 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.1 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling