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Results for DAL82

Z-value: 0.77

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Transcription factors associated with DAL82

Gene Symbol Gene ID Gene Info
DAL82
S000005258 Positive regulator of allophanate inducible genes

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DAL82YNL314W-0.861.5e-08Click!

Activity profile of DAL82 motif

Sorted Z-values of DAL82 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YGR108W 4.39
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YJR094W-A 4.21
RPL43B
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YJL153C 4.15
INO1
Inositol 1-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
YOL086C 3.45
ADH1
Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YPL250W-A 3.36 Identified by fungal homology and RT-PCR
YNR016C 3.31
ACC1
Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids
YOR376W-A 2.89 Putative protein of unknown function; identified by fungal homology and RT-PCR
YLR167W 2.80
RPS31
Fusion protein that is cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B
YLR388W 2.79
RPS29A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Bp and has similarity to rat S29 and E. coli S14 ribosomal proteins
YGL123C-A 2.72 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene RPS2/YGL123W
YGL123W 2.69
RPS2
Protein component of the small (40S) subunit, essential for control of translational accuracy; has similarity to E. coli S5 and rat S2 ribosomal proteins
YMR199W 2.67
CLN1
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YER131W 2.59
RPS26B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YCR018C 2.53
SRD1
Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YHL015W 2.45
RPS20
Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; has similarity to E. coli S10 and rat S20 ribosomal proteins
YLR437C 2.44 Putative protein of unknown function; epitope tagged protein localizes to the cytoplasm
YBL003C 2.44
HTA2
One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
YIL009W 2.37
FAA3
Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YMR083W 2.28
ADH3
Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YFR055W 2.25
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YPL131W 2.25
RPL5
Protein component of the large (60S) ribosomal subunit with similarity to E. coli L18 and rat L5 ribosomal proteins; binds 5S rRNA and is required for 60S subunit assembly
YOR096W 2.25
RPS7A
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
YIL009C-A 2.23
EST3
Component of the telomerase holoenzyme, involved in telomere replication
YBL002W 2.21
HTB2
One of two nearly identical (see HTB1) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
YOR315W 2.16
SFG1
Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
YOL101C 2.10
IZH4
Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism
YGR242W 2.09 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
YOR375C 2.08
GDH1
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources
YNR001W-A 2.03 Dubious open reading frame unlikely to encode a functional protein; identified by homology
YFL015C 2.03 Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
YNR018W 2.02
AIM38
Putative protein of unknown function; non-tagged protein is detected in purified mitochondria; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YLL045C 1.93
RPL8B
Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits
YFL015W-A 1.93 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR210W 1.93
ERV15
Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p
YJL190C 1.90
RPS22A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Bp and has similarity to E. coli S8 and rat S15a ribosomal proteins
YPL245W 1.86 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
YFR056C 1.85 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YNL066W 1.81
SUN4
Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family
YGR241C 1.77
YAP1802
Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1801p, member of the AP180 protein family
YNL178W 1.77
RPS3
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YOL015W 1.75
IRC10
Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci
YNL069C 1.74
RPL16B
N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Ap, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
YNL289W 1.74
PCL1
Pho85 cyclin of the Pcl1,2-like subfamily, involved in entry into the mitotic cell cycle and regulation of morphogenesis, localizes to sites of polarized cell growth
YBR032W 1.66 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YJL011C 1.64
RPC17
RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex
YMR251W-A 1.63
HOR7
Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor
YOR342C 1.60 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YOL085C 1.59 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A
YLR448W 1.59
RPL6B
Protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Ap and to rat L6 ribosomal protein; binds to 5.8S rRNA
YHL003C 1.57
LAG1
Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p
YKL009W 1.56
MRT4
Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus
YFL022C 1.54
FRS2
Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
YKL152C 1.53
GPM1
Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
YIR031C 1.50
DAL7
Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YDR509W 1.49 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR508C 1.48
GNP1
High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids
YDR454C 1.47
GUK1
Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins
YDR033W 1.47
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YMR121C 1.46
RPL15B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Ap and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA
YBR009C 1.44
HHF1
One of two identical histone H4 proteins (see also HHF2); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
YMR102C 1.42 Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
YDR345C 1.42
HXT3
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YMR009W 1.41
ADI1
Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions
YPR069C 1.40
SPE3
Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells
YLR367W 1.39
RPS22B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Ap and has similarity to E. coli S8 and rat S15a ribosomal proteins
YEL068C 1.39 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL202W 1.38
ARO8
Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis
YOL016C 1.37
CMK2
Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk1p and mammalian Cam Kinase II
YLR355C 1.36
ILV5
Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA and found in mitochondrial nucleoids
YNL193W 1.35 Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis
YBL072C 1.33
RPS8A
Protein component of the small (40S) ribosomal subunit; identical to Rps8Bp and has similarity to rat S8 ribosomal protein
YBR191W 1.32
RPL21A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Bp and has similarity to rat L21 ribosomal protein
YML063W 1.32
RPS1B
Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Ap and has similarity to rat S3a ribosomal protein
YEL066W 1.32
HPA3
D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro
YGR249W 1.31
MGA1
Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants
YGL209W 1.30
MIG2
Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter
YML123C 1.30
PHO84
High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p
YPR148C 1.30 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YKL096W-A 1.28
CWP2
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YKL164C 1.28
PIR1
O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle
YHR032W-A 1.27 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YHR032C-A
YNR003C 1.27
RPC34
RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex
YHR141C 1.25
RPL42B
Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to rat L44; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus
YDR044W 1.24
HEM13
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YHR201C 1.24
PPX1
Exopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix
YCR022C 1.23 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene
YGR055W 1.22
MUP1
High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
YMR122W-A 1.22 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and endoplasmic reticulum
YOR293W 1.22
RPS10A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Bp and has similarity to rat ribosomal protein S10
YHR216W 1.19
IMD2
Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation
YGL225W 1.19
VRG4
Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi
YPL028W 1.17
ERG10
Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis
YGL039W 1.17 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YKL218C 1.17
SRY1
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YIL148W 1.16
RPL40A
Fusion protein, identical to Rpl40Bp, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes
YOR029W 1.15 Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YOR107W 1.15
RGS2
Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p
YJL158C 1.13
CIS3
Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
YOL155C 1.12
HPF1
Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines
YLR154C 1.12
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YIR021W 1.10
MRS1
Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YMR082C 1.10 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR011W 1.10
HXT2
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YOR312C 1.09
RPL20B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Ap and has similarity to rat L18a ribosomal protein
YER073W 1.09
ALD5
Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed
YML073C 1.09
RPL6A
N-terminally acetylated protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Bp and to rat L6 ribosomal protein; binds to 5.8S rRNA
YDL191W 1.09
RPL35A
Protein component of the large (60S) ribosomal subunit, identical to Rpl35Bp and has similarity to rat L35 ribosomal protein
YMR123W 1.08
PKR1
V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); overproduction confers resistance to Pichia farinosa killer toxin
YIL163C 1.08 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR180C 1.08
RNR4
Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
YBR066C 1.08
NRG2
Transcriptional repressor that mediates glucose repression and negatively regulates filamentous growth; has similarity to Nrg1p
YNL175C 1.07
NOP13
Protein of unknown function, localizes to the nucleolus and nucleoplasm; contains an RNA recognition motif (RRM) and has similarity to Nop12p, which is required for processing of pre-18S rRNA
YGR106C 1.07
VOA1
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane
YEL067C 1.05 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YER091C 1.05
MET6
Cobalamin-independent methionine synthase, involved in amino acid biosynthesis; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs
YNL030W 1.05
HHF2
One of two identical histone H4 proteins (see also HHF1); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
YDL007W 1.05
RPT2
One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
YIL118W 1.04
RHO3
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YDR400W 1.04
URH1
Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways
YDR531W 1.03 Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway leading to coenzyme A1
YMR146C 1.03
TIF34
Subunit of the core complex of translation initiation factor 3(eIF3), which is essential for translation
YPL246C 1.02
RBD2
Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
YGL147C 1.02
RPL9A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins
YPR043W 1.01
RPL43A
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Bp and has similarity to rat L37a ribosomal protein; null mutation confers a dominant lethal phenotype
YKR026C 1.01
GCN3
Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression
YMR001C-A 0.99 Putative protein of unknown function
YMR006C 0.99
PLB2
Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine
YKL068W-A 0.98 Putative protein of unknown function; identified by homology to Ashbya gossypii
YIL052C 0.98
RPL34B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Ap and has similarity to rat L34 ribosomal protein
YMR143W 0.98
RPS16A
Protein component of the small (40S) ribosomal subunit; identical to Rps16Bp and has similarity to E. coli S9 and rat S16 ribosomal proteins
YNR017W 0.98
TIM23
Essential protein of the mitochondrial inner membrane, component of the mitochondrial import system
YGR279C 0.96
SCW4
Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating
YGL040C 0.96
HEM2
Delta-aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen, the second step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus
YHR005C-A 0.96
MRS11
Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that mediates insertion of hydrophobic proteins at the inner membrane, has homology to Mrs5p, which is also involved in this process
YGR214W 0.96
RPS0A
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YFL016C 0.94
MDJ1
Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones
YER012W 0.93
PRE1
Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
YFR031C-A 0.93
RPL2A
Protein component of the large (60S) ribosomal subunit, identical to Rpl2Bp and has similarity to E. coli L2 and rat L8 ribosomal proteins
YGR124W 0.93
ASN2
Asparagine synthetase, isozyme of Asn1p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway
YLR154W-B 0.93 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YJR105W 0.92
ADO1
Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
YBR010W 0.91
HHT1
One of two identical histone H3 proteins (see also HHT2); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation
YOR028C 0.91
CIN5
Basic leucine zipper transcriptional factor of the yAP-1 family that mediates pleiotropic drug resistance and salt tolerance; localizes constitutively to the nucleus
YMR142C 0.91
RPL13B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Ap; not essential for viability; has similarity to rat L13 ribosomal protein
YDR344C 0.91 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR297W 0.91
SUR2
Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis
YOR314W 0.90 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR045W 0.89 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
YBR087W 0.89
RFC5
Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
YGL076C 0.89
RPL7A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Bp and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)
YOL161C 0.89
PAU20
Hypothetical protein
YGR107W 0.89 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR232W 0.88
MGE1
Protein of the mitochondrial matrix involved in protein import into mitochondria; acts as a cochaperone and a nucleotide release factor for Ssc1p; homolog of E. coli GrpE
YLR154W-A 0.88 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YGR251W 0.88 Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YPL210C 0.88
SRP72
Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
YDR279W 0.87
RNH202
Ribonuclease H2 subunit, required for RNase H2 activity
YLR029C 0.87
RPL15A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Bp and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA
YOL120C 0.87
RPL18A
Protein component of the large (60S) ribosomal subunit, identical to Rpl18Bp and has similarity to rat L18 ribosomal protein; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation
YDR284C 0.87
DPP1
Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism
YOR095C 0.86
RKI1
Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis
YLR349W 0.86 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C
YOL107W 0.86 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein
YLR348C 0.85
DIC1
Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix
YMR116C 0.84
ASC1
G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; represses Gcn4p in the absence of amino acid starvation
YDL008W 0.82
APC11
Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
YER130C 0.82 Hypothetical protein
YPL007C 0.82
TFC8
One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90
YDL047W 0.81
SIT4
Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
YDL121C 0.80 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic retiuculum; YDL121C is not an essential protein
YAL012W 0.79
CYS3
Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine
YGR123C 0.79
PPT1
Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth; computational analyses suggest roles in phosphate metabolism and rRNA processing
YBR283C 0.79
SSH1
Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential
YDL211C 0.78 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YCR099C 0.78 Putative protein of unknown function
YMR132C 0.78
JLP2
Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)
YBL063W 0.78
KIP1
Kinesin-related motor protein required for mitotic spindle assembly and chromosome segregation; functionally redundant with Cin8p
YMR038C 0.77
CCS1
Copper chaperone for superoxide dismutase Sod1p, involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation
YNL090W 0.77
RHO2
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly
YOR011W 0.77
AUS1
Transporter of the ATP-binding cassette family, involved in uptake of sterols and anaerobic growth
YBL028C 0.76 Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
YOR310C 0.76
NOP58
Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA
YJL087C 0.76
TRL1
tRNA ligase, required for tRNA splicing; composed of three essential domains containing the phosphodiesterase, polynucleotide kinase, and ligase activities required for ligation; localized at the inner membrane of the nuclear envelope
YGL255W 0.76
ZRT1
High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YDR418W 0.75
RPL12B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins
YER046W 0.75
SPO73
Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis
YDR261C 0.75
EXG2
Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YGR181W 0.74
TIM13
Mitochondrial intermembrane space protein, forms a complex with TIm8p that mediates import and insertion of a subset of polytopic inner membrane proteins; may prevent aggregation of incoming proteins in a chaperone-like manner
YOR013W 0.74
IRC11
Dubious opening reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012C; null mutant displays increased levels of spontaneous Rad52 foci
YEL001C 0.74
IRC22
Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
YJL196C 0.74
ELO1
Elongase I, medium-chain acyl elongase, catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids
YNL028W 0.73 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAL033W 0.73
POP5
Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YHR181W 0.73
SVP26
Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YHR128W 0.72
FUR1
Uracil phosphoribosyltransferase, synthesizes UMP from uracil; involved in the pyrimidine salvage pathway
YGR148C 0.71
RPL24B
Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YBR104W 0.71
YMC2
Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p
YJR057W 0.70
CDC8
Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p
YMR266W 0.70
RSN1
Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant
YMR319C 0.70
FET4
Low-affinity Fe(II) transporter of the plasma membrane

Network of associatons between targets according to the STRING database.

First level regulatory network of DAL82

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 6.4 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.6 3.8 GO:0006021 inositol biosynthetic process(GO:0006021)
0.6 6.1 GO:0006116 NADH oxidation(GO:0006116)
0.6 10.9 GO:0051029 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
0.6 1.8 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.6 1.7 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.6 3.9 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
0.5 1.5 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.5 3.0 GO:0046037 GMP metabolic process(GO:0046037)
0.5 1.4 GO:0008216 spermidine metabolic process(GO:0008216)
0.5 1.4 GO:1902223 tyrosine biosynthetic process(GO:0006571) L-phenylalanine biosynthetic process(GO:0009094) erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process(GO:1902223)
0.4 1.3 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.4 0.9 GO:0030541 plasmid partitioning(GO:0030541)
0.4 57.3 GO:0002181 cytoplasmic translation(GO:0002181)
0.4 1.1 GO:0038032 termination of signal transduction(GO:0023021) termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.4 9.5 GO:0006334 nucleosome assembly(GO:0006334)
0.4 0.7 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.4 1.5 GO:0015680 intracellular copper ion transport(GO:0015680)
0.4 1.1 GO:0044209 AMP salvage(GO:0044209)
0.3 2.1 GO:0006672 ceramide metabolic process(GO:0006672) ceramide biosynthetic process(GO:0046513)
0.3 1.7 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.3 1.0 GO:0043171 peptide catabolic process(GO:0043171)
0.3 1.0 GO:0042454 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356) ribonucleoside catabolic process(GO:0042454) cytidine metabolic process(GO:0046087)
0.3 1.4 GO:0000296 spermine transport(GO:0000296)
0.3 2.3 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.3 2.2 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.3 0.9 GO:2000879 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
0.3 0.3 GO:0014070 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
0.3 1.2 GO:1900436 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
0.3 1.2 GO:0090338 regulation of formin-nucleated actin cable assembly(GO:0090337) positive regulation of formin-nucleated actin cable assembly(GO:0090338)
0.3 1.6 GO:0009099 valine biosynthetic process(GO:0009099)
0.3 1.6 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.3 1.1 GO:0019346 transsulfuration(GO:0019346)
0.3 1.1 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.3 0.8 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.3 1.6 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.2 0.7 GO:0032262 pyrimidine ribonucleotide salvage(GO:0010138) pyrimidine nucleotide salvage(GO:0032262) pyrimidine nucleoside salvage(GO:0043097) UMP salvage(GO:0044206)
0.2 1.2 GO:0015780 nucleotide-sugar transport(GO:0015780)
0.2 2.2 GO:0006797 polyphosphate metabolic process(GO:0006797)
0.2 0.7 GO:0019413 acetate biosynthetic process(GO:0019413)
0.2 0.9 GO:0009423 chorismate biosynthetic process(GO:0009423) chorismate metabolic process(GO:0046417)
0.2 0.6 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
0.2 0.6 GO:0000101 sulfur amino acid transport(GO:0000101)
0.2 3.6 GO:0009304 tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.2 0.8 GO:0032056 positive regulation of translation in response to stress(GO:0032056)
0.2 0.8 GO:0006829 zinc II ion transport(GO:0006829)
0.2 0.6 GO:0010674 negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010674)
0.2 0.6 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.2 0.7 GO:0030497 fatty acid elongation(GO:0030497)
0.2 0.7 GO:0009090 homoserine biosynthetic process(GO:0009090)
0.2 0.9 GO:0060277 obsolete negative regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0060277)
0.2 2.7 GO:0007009 plasma membrane organization(GO:0007009)
0.2 2.3 GO:0007120 axial cellular bud site selection(GO:0007120)
0.2 0.5 GO:1904667 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.2 1.2 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.2 1.6 GO:0009395 phospholipid catabolic process(GO:0009395)
0.2 0.7 GO:0051597 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
0.2 0.8 GO:0071326 cellular glucose homeostasis(GO:0001678) carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255) carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.2 1.3 GO:0042538 hyperosmotic salinity response(GO:0042538)
0.2 0.2 GO:0043068 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.2 0.3 GO:0010695 regulation of spindle pole body separation(GO:0010695)
0.2 3.4 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.2 1.5 GO:0006882 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.2 0.3 GO:0071850 mitotic cell cycle arrest in response to pheromone(GO:0000751) mitotic cell cycle arrest(GO:0071850)
0.2 0.3 GO:0009097 isoleucine biosynthetic process(GO:0009097)
0.2 0.5 GO:0009298 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
0.1 1.0 GO:0046015 regulation of transcription by glucose(GO:0046015)
0.1 0.4 GO:0046677 response to antibiotic(GO:0046677)
0.1 1.7 GO:0090529 barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529)
0.1 0.4 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900) tetrahydrofolylpolyglutamate biosynthetic process(GO:0046901)
0.1 0.7 GO:0006491 N-glycan processing(GO:0006491)
0.1 2.4 GO:0032508 DNA duplex unwinding(GO:0032508)
0.1 0.8 GO:0015677 copper ion import(GO:0015677)
0.1 1.3 GO:0090662 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.1 0.4 GO:0006114 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.1 1.3 GO:0006272 leading strand elongation(GO:0006272)
0.1 0.4 GO:0009219 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) deoxyribonucleoside monophosphate metabolic process(GO:0009162) pyrimidine deoxyribonucleoside monophosphate metabolic process(GO:0009176) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177) pyrimidine deoxyribonucleotide metabolic process(GO:0009219) pyrimidine deoxyribonucleotide biosynthetic process(GO:0009221) 2'-deoxyribonucleotide biosynthetic process(GO:0009265) 2'-deoxyribonucleotide metabolic process(GO:0009394) deoxyribose phosphate biosynthetic process(GO:0046385)
0.1 0.7 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.1 0.6 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 3.3 GO:0006696 ergosterol biosynthetic process(GO:0006696) phytosteroid biosynthetic process(GO:0016129) cellular alcohol biosynthetic process(GO:0044108) cellular lipid biosynthetic process(GO:0097384)
0.1 0.2 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362)
0.1 2.2 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 0.3 GO:0006624 vacuolar protein processing(GO:0006624)
0.1 0.5 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.1 0.7 GO:0000372 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.1 1.0 GO:0000921 septin ring assembly(GO:0000921)
0.1 0.1 GO:0033239 negative regulation of cellular amine metabolic process(GO:0033239)
0.1 0.2 GO:0006343 establishment of chromatin silencing(GO:0006343) regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361) regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072363)
0.1 0.7 GO:0035376 sterol import(GO:0035376)
0.1 0.2 GO:0071454 response to anoxia(GO:0034059) cellular response to anoxia(GO:0071454)
0.1 0.4 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.1 0.4 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.1 0.1 GO:0090087 regulation of peptide transport(GO:0090087) regulation of oligopeptide transport(GO:0090088) regulation of dipeptide transport(GO:0090089)
0.1 0.8 GO:0016559 peroxisome fission(GO:0016559)
0.1 1.1 GO:0006450 regulation of translational fidelity(GO:0006450)
0.1 0.4 GO:0098609 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.1 0.3 GO:0034389 lipid particle organization(GO:0034389)
0.1 0.3 GO:0000092 mitotic anaphase B(GO:0000092)
0.1 0.7 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.1 0.3 GO:0090522 vesicle tethering involved in exocytosis(GO:0090522)
0.1 0.3 GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)(GO:0019379) sulfate reduction(GO:0019419)
0.1 1.2 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 0.2 GO:0030011 maintenance of cell polarity(GO:0030011)
0.1 0.6 GO:0034501 protein localization to kinetochore(GO:0034501)
0.1 0.7 GO:0034221 cell wall chitin biosynthetic process(GO:0006038) fungal-type cell wall chitin biosynthetic process(GO:0034221) fungal-type cell wall polysaccharide biosynthetic process(GO:0051278) fungal-type cell wall polysaccharide metabolic process(GO:0071966)
0.1 0.7 GO:0031070 intronic snoRNA processing(GO:0031070) intronic box C/D snoRNA processing(GO:0034965)
0.1 0.3 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.1 0.7 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.1 0.5 GO:0001041 transcription from RNA polymerase III type 2 promoter(GO:0001009) transcription from a RNA polymerase III hybrid type promoter(GO:0001041)
0.1 0.3 GO:0060188 regulation of protein desumoylation(GO:0060188)
0.1 0.2 GO:0071044 histone mRNA metabolic process(GO:0008334) histone mRNA catabolic process(GO:0071044)
0.1 0.2 GO:0045901 positive regulation of translational elongation(GO:0045901)
0.1 0.4 GO:0006825 copper ion transport(GO:0006825)
0.1 0.1 GO:0031106 septin ring organization(GO:0031106)
0.1 0.1 GO:0031384 regulation of initiation of mating projection growth(GO:0031384)
0.1 0.3 GO:0001927 exocyst assembly(GO:0001927)
0.1 1.6 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 0.4 GO:0090158 regulation of phosphatidylinositol dephosphorylation(GO:0060304) endoplasmic reticulum membrane organization(GO:0090158)
0.1 0.3 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.1 0.1 GO:0046083 adenine metabolic process(GO:0046083)
0.1 0.5 GO:0048309 endoplasmic reticulum inheritance(GO:0048309)
0.1 1.7 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.1 0.6 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.1 0.3 GO:0016578 histone deubiquitination(GO:0016578)
0.1 0.8 GO:0006614 cotranslational protein targeting to membrane(GO:0006613) SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.1 0.8 GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process(GO:0071042) polyadenylation-dependent mRNA catabolic process(GO:0071047)
0.1 1.2 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.1 0.7 GO:0015918 sterol transport(GO:0015918)
0.1 1.2 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.1 0.2 GO:0010922 positive regulation of phosphatase activity(GO:0010922)
0.1 0.2 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.1 0.5 GO:0051231 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231)
0.1 0.3 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.1 0.1 GO:0071462 response to water(GO:0009415) cellular response to water stimulus(GO:0071462)
0.1 0.2 GO:0018206 N-terminal peptidyl-methionine acetylation(GO:0017196) peptidyl-methionine modification(GO:0018206)
0.1 0.1 GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472)
0.1 0.2 GO:0001015 snoRNA transcription from an RNA polymerase II promoter(GO:0001015) snoRNA transcription(GO:0009302)
0.1 0.1 GO:0048211 Golgi vesicle docking(GO:0048211)
0.1 0.1 GO:0045981 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.1 0.5 GO:0031145 anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.1 1.0 GO:0006446 regulation of translational initiation(GO:0006446)
0.1 0.1 GO:0090153 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.1 0.7 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1 0.9 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.1 0.3 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098)
0.1 0.6 GO:0006415 translational termination(GO:0006415)
0.1 0.1 GO:0019365 nicotinate nucleotide biosynthetic process(GO:0019357) nicotinate nucleotide salvage(GO:0019358) pyridine nucleotide salvage(GO:0019365) nicotinate nucleotide metabolic process(GO:0046497)
0.1 0.4 GO:0019856 pyrimidine nucleobase biosynthetic process(GO:0019856)
0.1 0.6 GO:0098876 Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.1 1.5 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.1 0.2 GO:0006734 NADH metabolic process(GO:0006734)
0.1 0.6 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.0 0.1 GO:0051303 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.0 0.2 GO:0060258 negative regulation of growth(GO:0045926) negative regulation of filamentous growth(GO:0060258)
0.0 0.6 GO:0006999 nuclear pore organization(GO:0006999)
0.0 0.7 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 0.6 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.0 0.2 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.0 0.1 GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000448)
0.0 0.3 GO:0043094 cellular metabolic compound salvage(GO:0043094)
0.0 0.4 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.0 GO:0071051 polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.0 0.9 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.0 0.1 GO:0030048 actin filament-based movement(GO:0030048) actin filament-based transport(GO:0099515)
0.0 0.1 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.0 0.5 GO:0000097 sulfur amino acid biosynthetic process(GO:0000097)
0.0 0.1 GO:0046473 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.0 0.3 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.1 GO:0035459 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.3 GO:0006817 phosphate ion transport(GO:0006817)
0.0 0.2 GO:0000743 nuclear migration involved in conjugation with cellular fusion(GO:0000743)
0.0 0.2 GO:0046112 nucleobase biosynthetic process(GO:0046112)
0.0 0.1 GO:0015886 heme transport(GO:0015886)
0.0 0.2 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.0 0.4 GO:0018208 protein peptidyl-prolyl isomerization(GO:0000413) peptidyl-proline modification(GO:0018208)
0.0 0.6 GO:0006184 obsolete GTP catabolic process(GO:0006184)
0.0 0.7 GO:0002098 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.0 0.1 GO:2000002 regulation of cell cycle checkpoint(GO:1901976) negative regulation of cell cycle checkpoint(GO:1901977) regulation of DNA damage checkpoint(GO:2000001) negative regulation of DNA damage checkpoint(GO:2000002) negative regulation of response to DNA damage stimulus(GO:2001021)
0.0 0.1 GO:0007234 osmosensory signaling via phosphorelay pathway(GO:0007234)
0.0 0.1 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.0 0.4 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.0 3.0 GO:0006364 rRNA processing(GO:0006364)
0.0 0.1 GO:0031047 gene silencing involved in chronological cell aging(GO:0010978) gene silencing by RNA(GO:0031047)
0.0 0.3 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.0 0.1 GO:0015883 FAD transport(GO:0015883)
0.0 0.1 GO:0030846 termination of RNA polymerase II transcription, poly(A)-coupled(GO:0030846)
0.0 0.4 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.1 GO:0006056 cell wall mannoprotein biosynthetic process(GO:0000032) mannoprotein metabolic process(GO:0006056) mannoprotein biosynthetic process(GO:0006057) cell wall glycoprotein biosynthetic process(GO:0031506)
0.0 0.1 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.0 0.0 GO:0033241 regulation of cellular amine catabolic process(GO:0033241)
0.0 0.1 GO:0051260 protein homooligomerization(GO:0051260)
0.0 0.1 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.1 GO:0051469 vesicle fusion with vacuole(GO:0051469)
0.0 0.2 GO:0017148 negative regulation of translation(GO:0017148) negative regulation of cellular amide metabolic process(GO:0034249)
0.0 0.4 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.0 0.1 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.0 0.1 GO:0010970 establishment of localization by movement along microtubule(GO:0010970) nuclear migration along microtubule(GO:0030473) cytoskeleton-dependent intracellular transport(GO:0030705) organelle transport along microtubule(GO:0072384)
0.0 0.2 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.1 GO:0015868 purine nucleotide transport(GO:0015865) purine ribonucleotide transport(GO:0015868)
0.0 0.1 GO:0046219 tryptophan biosynthetic process(GO:0000162) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
0.0 0.1 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.0 0.2 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.0 0.1 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.0 GO:0006517 protein deglycosylation(GO:0006517)
0.0 0.1 GO:0070096 mitochondrial outer membrane translocase complex assembly(GO:0070096)
0.0 0.0 GO:0006037 cell wall chitin metabolic process(GO:0006037)
0.0 0.1 GO:0006771 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.0 0.1 GO:0006760 folic acid-containing compound metabolic process(GO:0006760) pteridine-containing compound metabolic process(GO:0042558)
0.0 0.1 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.2 GO:0006479 protein methylation(GO:0006479) protein alkylation(GO:0008213)
0.0 0.1 GO:0072668 obsolete tubulin complex biogenesis(GO:0072668)
0.0 0.1 GO:0045324 late endosome to vacuole transport(GO:0045324)
0.0 0.1 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.0 0.1 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
0.0 0.2 GO:0051666 actin cortical patch localization(GO:0051666)
0.0 0.3 GO:0006400 tRNA modification(GO:0006400)
0.0 0.1 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.0 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.0 0.0 GO:1900461 positive regulation of cell growth(GO:0030307) positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter(GO:1900461) positive regulation of pseudohyphal growth(GO:2000222)
0.0 0.2 GO:0008361 regulation of cell size(GO:0008361)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 9.4 GO:0000788 nuclear nucleosome(GO:0000788)
0.7 2.0 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.5 31.2 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.4 37.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.4 6.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.3 1.1 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.3 1.6 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.3 0.8 GO:0071261 Ssh1 translocon complex(GO:0071261)
0.3 1.8 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.3 1.3 GO:0031389 DNA replication factor C complex(GO:0005663) Rad17 RFC-like complex(GO:0031389) Elg1 RFC-like complex(GO:0031391)
0.2 0.7 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.2 1.4 GO:0005871 kinesin complex(GO:0005871)
0.2 1.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.2 0.7 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.2 0.6 GO:0070985 TFIIK complex(GO:0070985)
0.2 3.6 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.2 1.0 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.2 0.8 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.2 0.6 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.2 2.2 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.2 0.5 GO:0000814 ESCRT II complex(GO:0000814)
0.2 1.0 GO:0001400 mating projection base(GO:0001400)
0.2 0.2 GO:0005640 nuclear outer membrane(GO:0005640)
0.2 1.1 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.2 1.1 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.2 0.9 GO:0005880 nuclear microtubule(GO:0005880)
0.1 1.0 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 1.0 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 0.6 GO:0097255 R2TP complex(GO:0097255)
0.1 0.6 GO:0033176 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) vacuolar proton-transporting V-type ATPase complex(GO:0016471) proton-transporting V-type ATPase complex(GO:0033176) proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.1 0.1 GO:0000133 polarisome(GO:0000133)
0.1 0.5 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 3.4 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 1.0 GO:0033101 cellular bud membrane(GO:0033101)
0.1 3.2 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 0.8 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 0.4 GO:0043529 GET complex(GO:0043529)
0.1 0.4 GO:0070545 PeBoW complex(GO:0070545)
0.1 0.3 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 0.8 GO:0005688 U6 snRNP(GO:0005688)
0.1 0.2 GO:0000786 nucleosome(GO:0000786)
0.1 0.5 GO:0034044 exomer complex(GO:0034044)
0.1 0.4 GO:0030869 RENT complex(GO:0030869)
0.1 1.0 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.1 0.4 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.1 0.5 GO:0034518 RNA cap binding complex(GO:0034518)
0.1 3.1 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.1 1.7 GO:0030118 clathrin coat(GO:0030118)
0.1 1.0 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 0.7 GO:0005655 nucleolar ribonuclease P complex(GO:0005655) multimeric ribonuclease P complex(GO:0030681)
0.1 1.3 GO:0030137 COPI-coated vesicle(GO:0030137)
0.1 0.5 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.1 0.3 GO:0030907 MBF transcription complex(GO:0030907)
0.1 0.8 GO:0005940 septin ring(GO:0005940)
0.1 1.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 0.3 GO:0031518 CBF3 complex(GO:0031518)
0.1 0.5 GO:0000145 exocyst(GO:0000145)
0.1 0.3 GO:0034448 EGO complex(GO:0034448)
0.1 0.3 GO:0071819 DUBm complex(GO:0071819)
0.1 0.1 GO:0044453 nuclear membrane part(GO:0044453)
0.1 0.3 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.1 0.4 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.1 0.9 GO:0030659 vesicle membrane(GO:0012506) cytoplasmic vesicle membrane(GO:0030659)
0.1 0.6 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 1.4 GO:0005844 polysome(GO:0005844)
0.0 0.8 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.2 GO:0070772 PAS complex(GO:0070772)
0.0 0.6 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.7 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.1 GO:0070939 Dsl1p complex(GO:0070939)
0.0 14.3 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 3.8 GO:0030684 preribosome(GO:0030684)
0.0 0.4 GO:0042729 DASH complex(GO:0042729)
0.0 0.4 GO:0036452 ESCRT complex(GO:0036452)
0.0 0.4 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.2 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112) core TFIIH complex(GO:0000439)
0.0 0.1 GO:0044426 cell wall part(GO:0044426) external encapsulating structure part(GO:0044462)
0.0 0.2 GO:0031499 TRAMP complex(GO:0031499)
0.0 0.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.5 GO:0000152 nuclear ubiquitin ligase complex(GO:0000152) anaphase-promoting complex(GO:0005680)
0.0 0.1 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.2 GO:0031414 N-terminal protein acetyltransferase complex(GO:0031414)
0.0 0.2 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 0.2 GO:0042555 MCM complex(GO:0042555)
0.0 0.1 GO:0070823 HDA1 complex(GO:0070823)
0.0 0.0 GO:0033309 SBF transcription complex(GO:0033309)
0.0 3.4 GO:0005933 cellular bud(GO:0005933)
0.0 0.1 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.0 0.5 GO:0016592 mediator complex(GO:0016592)
0.0 1.0 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.0 GO:0000131 incipient cellular bud site(GO:0000131)
0.0 0.1 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.1 GO:0035097 histone methyltransferase complex(GO:0035097) Set1C/COMPASS complex(GO:0048188)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 GO:0016872 intramolecular lyase activity(GO:0016872)
0.9 5.5 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.8 2.4 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.7 2.2 GO:0008097 5S rRNA binding(GO:0008097)
0.7 2.8 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
0.7 2.7 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.5 1.6 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.5 1.5 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.5 3.0 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.5 2.0 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.5 1.5 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
0.4 4.5 GO:0031386 protein tag(GO:0031386)
0.4 1.7 GO:0004622 lysophospholipase activity(GO:0004622)
0.4 1.6 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.4 1.5 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.4 9.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.4 1.1 GO:0019003 GDP binding(GO:0019003)
0.4 1.1 GO:0016504 peptidase activator activity(GO:0016504)
0.3 1.7 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.3 1.4 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.3 1.4 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
0.3 1.3 GO:0004338 glucan exo-1,3-beta-glucosidase activity(GO:0004338)
0.3 0.7 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467) fatty acid ligase activity(GO:0015645)
0.3 1.6 GO:0008312 7S RNA binding(GO:0008312)
0.3 9.8 GO:0046982 protein heterodimerization activity(GO:0046982)
0.3 2.2 GO:0019201 nucleotide kinase activity(GO:0019201)
0.3 1.8 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.3 1.2 GO:0016841 ammonia-lyase activity(GO:0016841)
0.3 56.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.3 0.8 GO:0015248 sterol transporter activity(GO:0015248)
0.3 1.1 GO:0016725 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.3 2.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.3 1.6 GO:0016408 C-acyltransferase activity(GO:0016408)
0.3 1.0 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)
0.2 0.7 GO:0009922 fatty acid elongase activity(GO:0009922)
0.2 1.2 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.2 1.7 GO:0019205 nucleobase-containing compound kinase activity(GO:0019205)
0.2 0.7 GO:0016433 rRNA (adenine) methyltransferase activity(GO:0016433)
0.2 0.7 GO:0019202 amino acid kinase activity(GO:0019202)
0.2 0.7 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.2 3.6 GO:0001056 RNA polymerase III activity(GO:0001056)
0.2 1.3 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.2 1.0 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.2 0.6 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.2 1.0 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.2 1.1 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.2 0.6 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.2 0.6 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.2 0.9 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.2 0.5 GO:0072341 modified amino acid binding(GO:0072341)
0.2 0.5 GO:0051219 phosphoprotein binding(GO:0051219)
0.2 3.1 GO:0015926 glucosidase activity(GO:0015926)
0.2 0.7 GO:0016531 copper chaperone activity(GO:0016531)
0.2 0.6 GO:0008172 S-methyltransferase activity(GO:0008172)
0.2 0.5 GO:0000339 RNA cap binding(GO:0000339)
0.2 0.5 GO:0003785 actin monomer binding(GO:0003785)
0.1 0.4 GO:0004629 phospholipase C activity(GO:0004629)
0.1 1.0 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
0.1 1.1 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 1.1 GO:0003777 microtubule motor activity(GO:0003777)
0.1 0.4 GO:0004326 tetrahydrofolylpolyglutamate synthase activity(GO:0004326)
0.1 1.6 GO:0005516 calmodulin binding(GO:0005516)
0.1 0.5 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.4 GO:0004738 pyruvate dehydrogenase activity(GO:0004738)
0.1 1.3 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.1 0.5 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
0.1 0.4 GO:0070568 guanylyltransferase activity(GO:0070568)
0.1 0.6 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.1 0.7 GO:0030145 manganese ion binding(GO:0030145)
0.1 0.5 GO:0004771 sterol esterase activity(GO:0004771)
0.1 0.8 GO:0001054 RNA polymerase I activity(GO:0001054)
0.1 2.3 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 1.7 GO:0019843 rRNA binding(GO:0019843)
0.1 0.6 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.1 0.6 GO:0005496 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.1 0.7 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.1 1.5 GO:0001671 ATPase activator activity(GO:0001671)
0.1 0.3 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 0.4 GO:0001128 RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly(GO:0001128)
0.1 0.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.3 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 0.4 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 0.3 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.1 0.6 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 0.2 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.1 0.4 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.1 0.3 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.1 0.3 GO:0016882 cyclo-ligase activity(GO:0016882)
0.1 0.3 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 0.3 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.1 0.3 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296) single-stranded DNA exodeoxyribonuclease activity(GO:0008297) single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.1 0.7 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.1 0.5 GO:0001003 RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003) transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting(GO:0001004) transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIB recruiting(GO:0001005) transcription factor activity, RNA polymerase III type 2 promoter sequence-specific binding, TFIIIB recruiting(GO:0001008) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034)
0.1 0.7 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 0.4 GO:0042123 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.1 2.0 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 0.1 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 0.2 GO:0005262 calcium channel activity(GO:0005262)
0.1 0.7 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.1 0.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.2 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.1 0.4 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.1 0.2 GO:0016880 acid-ammonia (or amide) ligase activity(GO:0016880)
0.1 1.1 GO:0005048 signal sequence binding(GO:0005048)
0.1 2.0 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 0.3 GO:0003993 acid phosphatase activity(GO:0003993)
0.1 0.9 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.1 0.4 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 0.3 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 1.6 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 3.0 GO:0003924 GTPase activity(GO:0003924)
0.0 0.5 GO:0043022 ribosome binding(GO:0043022)
0.0 0.2 GO:0004707 MAP kinase activity(GO:0004707)
0.0 1.0 GO:0016835 carbon-oxygen lyase activity(GO:0016835)
0.0 0.5 GO:0019239 deaminase activity(GO:0019239)
0.0 0.1 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.0 0.9 GO:0008017 microtubule binding(GO:0008017)
0.0 0.7 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.1 GO:0008443 phosphofructokinase activity(GO:0008443)
0.0 0.2 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.4 GO:0019904 protein domain specific binding(GO:0019904)
0.0 2.2 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.2 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 0.3 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.3 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0 0.1 GO:0034062 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 1.5 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.3 GO:0019237 centromeric DNA binding(GO:0019237)
0.0 0.5 GO:0005199 structural constituent of cell wall(GO:0005199)
0.0 0.2 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0 0.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.5 GO:0015605 organophosphate ester transmembrane transporter activity(GO:0015605)
0.0 0.1 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.0 0.1 GO:0003840 gamma-glutamyltransferase activity(GO:0003840)
0.0 0.1 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.1 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.5 GO:0016866 intramolecular transferase activity(GO:0016866)
0.0 0.9 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.1 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.0 0.2 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0 0.4 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.2 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.1 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438) phosphatidylinositol monophosphate phosphatase activity(GO:0052744)
0.0 0.2 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.1 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.2 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.0 GO:0015211 purine nucleoside transmembrane transporter activity(GO:0015211)
0.0 0.3 GO:0000049 tRNA binding(GO:0000049)
0.0 0.1 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
0.0 0.1 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0 0.1 GO:0070336 flap-structured DNA binding(GO:0070336)
0.0 0.7 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.0 0.2 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.1 GO:1901618 organic hydroxy compound transmembrane transporter activity(GO:1901618)
0.0 0.1 GO:0008144 drug binding(GO:0008144)
0.0 0.0 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.1 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.0 0.6 GO:0003724 RNA helicase activity(GO:0003724)
0.0 0.1 GO:0030276 clathrin binding(GO:0030276)
0.0 0.1 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.0 0.0 GO:0019776 Atg8 ligase activity(GO:0019776)
0.0 0.6 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 0.1 GO:0043141 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 0.5 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.1 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.2 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 0.2 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.0 GO:0016405 CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
0.0 0.2 GO:0043495 protein anchor(GO:0043495)
0.0 0.1 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.0 0.1 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.2 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.1 GO:0000384 first spliceosomal transesterification activity(GO:0000384)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 PID SHP2 PATHWAY SHP2 signaling
0.3 0.8 PID FGF PATHWAY FGF signaling pathway
0.2 0.5 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 0.9 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 1.1 PID FANCONI PATHWAY Fanconi anemia pathway
0.1 0.2 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 0.4 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 0.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.2 PID PLK1 PATHWAY PLK1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 7.2 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.5 1.4 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.4 7.2 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.4 1.3 REACTOME SIGNALING BY FGFR IN DISEASE Genes involved in Signaling by FGFR in disease
0.3 1.3 REACTOME TRANSCRIPTION COUPLED NER TC NER Genes involved in Transcription-coupled NER (TC-NER)
0.3 1.6 REACTOME TRANSLATION Genes involved in Translation
0.2 1.5 REACTOME SIGNALING BY GPCR Genes involved in Signaling by GPCR
0.1 0.6 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 0.4 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.1 1.0 REACTOME DEADENYLATION DEPENDENT MRNA DECAY Genes involved in Deadenylation-dependent mRNA decay
0.1 0.5 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 0.2 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 0.5 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 0.6 REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.0 0.1 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.1 REACTOME SIGNALING BY ERBB4 Genes involved in Signaling by ERBB4
0.0 0.1 REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION Genes involved in Platelet activation, signaling and aggregation
0.0 0.2 REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS Genes involved in Metabolism of lipids and lipoproteins
0.0 0.2 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.1 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.0 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.0 0.0 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes