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Results for CUP9

Z-value: 0.98

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Transcription factors associated with CUP9

Gene Symbol Gene ID Gene Info
CUP9
S000006098 Homeodomain-containing transcriptional repressor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
CUP9YPL177C0.509.9e-03Click!

Activity profile of CUP9 motif

Sorted Z-values of CUP9 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YMR017W 4.61
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YGR087C 4.20
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YHR139C 3.32
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YOR100C 3.10
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YMR107W 2.93
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YGR059W 2.86
SPR3
Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI
YOR255W 2.62
OSW1
Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p
YIL057C 2.55 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YFL011W 2.51
HXT10
Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YER065C 2.50
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YLR307W 2.39
CDA1
Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
YFL012W 2.39 Putative protein of unknown function; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin
YKL109W 2.31
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YDL114W 2.31 Putative protein of unknown function with similarity to acyl-carrier-protein reductases; YDL114W is not an essential gene
YAL062W 2.25
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YMR118C 2.23 Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene
YLR307C-A 2.22 Putative protein of unknown function
YCL048W 2.18
SPS22
Protein of unknown function, redundant with Sps2p for the organization of the beta-glucan layer of the spore wall
YER106W 2.16
MAM1
Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle
YML089C 2.14 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YGL205W 2.07
POX1
Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
YPL021W 2.06
ECM23
Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p
YNL318C 1.84
HXT14
Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YFR023W 1.84
PES4
Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation, similar to Mip6p
YBR180W 1.80
DTR1
Putative dityrosine transporter, required for spore wall synthesis; expressed during sporulation; member of the major facilitator superfamily (DHA1 family) of multidrug resistance transporters
YKL177W 1.72 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene STE3
YBR117C 1.64
TKL2
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YPR078C 1.63 Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible
YLR136C 1.62
TIS11
mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis
YNL117W 1.62
MLS1
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YAL067C 1.56
SEO1
Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
YFL051C 1.54 Putative protein of unknown function; YFL051C is not an essential gene
YAR069C 1.52 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR218C 1.48
SPR28
Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation
YJR154W 1.47 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YML090W 1.46 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YAL018C 1.46 Putative protein of unknown function
YAR070C 1.46 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR346C 1.44 Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene
YML091C 1.44
RPM2
Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
YAR050W 1.43
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YBR051W 1.41 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase
YDR281C 1.41
PHM6
Protein of unknown function, expression is regulated by phosphate levels
YJR095W 1.36
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YHR015W 1.36
MIP6
Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export
YAR053W 1.34 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YCL054W 1.33
SPB1
AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants
YNR062C 1.32 Putative membrane protein of unknown function
YKR102W 1.32
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YNL183C 1.30
NPR1
Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation
YER024W 1.30
YAT2
Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane
YDR446W 1.29
ECM11
Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure
YPR169W-A 1.28 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps two other dubious ORFs: YPR170C and YPR170W-B
YLR308W 1.28
CDA2
Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
YGR243W 1.27
FMP43
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJR048W 1.26
CYC1
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YGR088W 1.25
CTT1
Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YNR063W 1.24 Putative zinc-cluster protein of unknown function
YBR144C 1.23 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene
YDL210W 1.23
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YAR047C 1.22 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR048W 1.22
YHK8
Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
YDR242W 1.22
AMD2
Putative amidase
YBR050C 1.20
REG2
Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
YNR064C 1.20 Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides
YAL066W 1.19 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL170C 1.17
SPO74
Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation
YHR145C 1.16 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL178C 1.15
STE3
Receptor for a factor receptor, transcribed in alpha cells and required for mating by alpha cells, couples to MAP kinase cascade to mediate pheromone response; ligand bound receptors are endocytosed and recycled to the plasma membrane; GPCR
YLR327C 1.12
TMA10
Protein of unknown function that associates with ribosomes
YBR296C 1.11
PHO89
Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
YJL045W 1.11 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YPR002W 1.06
PDH1
Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate
YHR139C-A 1.06 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR194C-B 1.05 Putative protein of unknown function
YFL012W-A 1.05 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene IES1/YFL013C
YHL040C 1.05
ARN1
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores
YOR186W 1.04 Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent
YMR244W 1.03 Putative protein of unknown function
YDR445C 1.02 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL117W 1.00 Putative protein of unknown function
YOL052C-A 0.98
DDR2
Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses
YFR032C-B 0.96 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YEL049W 0.96
PAU2
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YKL161C 0.96 Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; associates with Rlm1p
YKR034W 0.96
DAL80
Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Deh1p
YPL092W 0.95
SSU1
Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein
YGR258C 0.95
RAD2
Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
YCL018W 0.93
LEU2
Beta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis pathway
YBR250W 0.93
SPO23
Protein of unknown function; associates with meiosis-specific protein Spo1p
YPL222C-A 0.92 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YBR179C 0.92
FZO1
Mitochondrial integral membrane protein involved in mitochondrial fusion and maintenance of the mitochondrial genome; contains N-terminal GTPase domain
YOR237W 0.92
HES1
Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP)
YMR280C 0.91
CAT8
Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements
YIL160C 0.91
POT1
3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
YAR035W 0.91
YAT1
Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
YKR105C 0.91
VBA5
Putative transporter of the Major Facilitator Superfamily (MFS); proposed role as a basic amino acid permease based on phylogeny
YOL082W 0.90
ATG19
Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; recognizes cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) and delivers them to the preautophagosomal structure for packaging into Cvt vesicles
YHR095W 0.89 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR094W 0.89
PBY1
Putative tubulin tyrosine ligase associated with P-bodies
YMR040W 0.87
YET2
Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
YDR042C 0.86 Putative protein of unknown function; expression is increased in ssu72-ts69 mutant
YOL050C 0.86 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YFR029W 0.85
PTR3
Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
YPL147W 0.85
PXA1
Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins
YJR151C 0.84
DAN4
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YFL013C 0.84
IES1
Subunit of the INO80 chromatin remodeling complex
YCL069W 0.84
VBA3
Permease of basic amino acids in the vacuolar membrane
YNL180C 0.83
RHO5
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
YDL085W 0.83
NDE2
Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
YOL024W 0.82 Putative protein of unknown function, predicted to have thiol-disulfide oxidoreductase active site
YDL204W 0.82
RTN2
Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily
YBR040W 0.82
FIG1
Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating
YMR090W 0.81 Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR090W is not an essential gene
YHL035C 0.81
VMR1
Protein of unknown function that may interact with ribosomes, based on co-purification experiments; member of the ATP-binding cassette (ABC) family; potential Cdc28p substrate; detected in purified mitochondria in high-throughput studies
YPR193C 0.81
HPA2
Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity
YDR043C 0.80
NRG1
Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YNL179C 0.80 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
YFL030W 0.79
AGX1
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YML058W-A 0.79
HUG1
Protein involved in the Mec1p-mediated checkpoint pathway that responds to DNA damage or replication arrest, transcription is induced by DNA damage
YOR211C 0.78
MGM1
Mitochondrial GTPase related to dynamin, present in a complex containing Ugo1p and Fzo1p; required for normal morphology of cristae and for stability of Tim11p; homolog of human OPA1 involved in autosomal dominant optic atrophy
YKL163W 0.78
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YBR072W 0.78
HSP26
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YER116C 0.76
SLX8
Subunit of the Slx5-Slx8 substrate-specific ubiquitin ligase complex; stimulated by prior attachment of SUMO to the substrate
YDR310C 0.76
SUM1
Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; involved in telomere maintenance, regulated by the pachytene checkpoint
YGL163C 0.76
RAD54
DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family
YDR223W 0.75
CRF1
Transcriptional corepressor involved in the regulation of ribosomal protein gene transcription via the TOR signaling pathway and protein kinase A, phosphorylated by activated Yak1p which promotes accumulation of Crf1p in the nucleus
YHR150W 0.75
PEX28
Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p
YJL043W 0.75 Putative protein of unknown function; YJL043W is a non-essential gene
YOR192C-C 0.75 Putative protein of unknown function; identified by expression profiling and mass spectrometry
YER097W 0.75 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR195W 0.74
ICY1
Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
YDL115C 0.74
IWR1
Protein of unknown function, deletion causes hypersensitivity to the K1 killer toxin
YGL118C 0.74 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL037C 0.74
PRM2
Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p
YOR192C 0.74
THI72
Transporter of thiamine or related compound; shares sequence similarity with Thi7p
YAR060C 0.74 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR540C 0.72
IRC4
Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YNL328C 0.72
MDJ2
Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain
YBR215W 0.71
HPC2
Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes
YGR110W 0.71 Putative protein of unknown function; transcription is increased in response to genotoxic stress; plays a role in restricting Ty1 transposition
YAL063C 0.70
FLO9
Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
YHR211W 0.69
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YGR065C 0.69
VHT1
High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
YOR289W 0.69 Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YJR047C 0.68
ANB1
Translation initiation factor eIF-5A, promotes formation of the first peptide bond; similar to and functionally redundant with Hyp2p; undergoes an essential hypusination modification; expressed under anaerobic conditions
YMR317W 0.68 Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene
YDR528W 0.67
HLR1
Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A
YKL217W 0.67
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YDR259C 0.66
YAP6
Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance
YER014C-A 0.66
BUD25
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YLL056C 0.65 Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene
YMR316C-B 0.65 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR054C 0.65
OSW2
Protein of unknown function proposed to be involved in the assembly of the spore wall
YOR365C 0.65 Putative protein of unknown function; YOR365C is not an essential protein
YDR119W-A 0.64 Putative protein of unknown function
YPL271W 0.64
ATP15
Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YMR014W 0.64
BUD22
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YIR014W 0.63 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene
YOR345C 0.62 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YBR018C 0.62
GAL7
Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism
YCR091W 0.62
KIN82
Putative serine/threonine protein kinase, most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily
YER098W 0.62
UBP9
Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions
YKL202W 0.61 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR347C 0.61
PYK2
Pyruvate kinase that appears to be modulated by phosphorylation; PYK2 transcription is repressed by glucose, and Pyk2p may be active under low glycolytic flux
YMR081C 0.61
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YIR029W 0.61
DAL2
Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YOR306C 0.60
MCH5
Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport
YGR182C 0.60 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W
YPR065W 0.60
ROX1
Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity
YMR013C 0.60
SEC59
Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation
YOR339C 0.60
UBC11
Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2
YOL100W 0.59
PKH2
Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p
YHR093W 0.59
AHT1
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region
YER061C 0.59
CEM1
Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration
YBR269C 0.58
FMP21
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPL018W 0.58
CTF19
Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly
YHR033W 0.57 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YMR016C 0.57
SOK2
Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; negatively regulates pseudohyphal differentiation; homologous to several transcription factors
YFL003C 0.57
MSH4
Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein
YML047C 0.57
PRM6
Pheromone-regulated protein, predicted to have 2 transmembrane segments; regulated by Ste12p during mating
YOR346W 0.56
REV1
Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YPL258C 0.55
THI21
Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p
YLR369W 0.54
SSQ1
Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia
YGR039W 0.54 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722
YDR542W 0.54
PAU10
Hypothetical protein
YFR012W 0.54 Putative protein of unknown function
YIL077C 0.54 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YDL187C 0.53 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLL047W 0.53 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1
YIL023C 0.53
YKE4
Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family
YJR049C 0.53
UTR1
ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p)
YHR212C 0.53 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKR015C 0.53 Putative protein of unknown function
YHR023W 0.52
MYO1
Type II myosin heavy chain, required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively
YBR147W 0.52
RTC2
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays fluconazole resistance and suppresses cdc13-1 temperature sensitivity
YMR018W 0.52 Putative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein); transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene
YMR141C 0.52 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL052W 0.51
COX5A
Subunit Va of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth
YOR382W 0.51
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall

Network of associatons between targets according to the STRING database.

First level regulatory network of CUP9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.2 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
0.7 2.2 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.7 4.5 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.7 2.2 GO:0006577 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
0.5 4.8 GO:0006097 glyoxylate cycle(GO:0006097)
0.5 1.9 GO:0006848 pyruvate transport(GO:0006848)
0.5 2.4 GO:0006032 aminoglycan catabolic process(GO:0006026) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.4 1.3 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.4 1.1 GO:0019543 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
0.4 1.8 GO:0008053 mitochondrial fusion(GO:0008053)
0.3 0.7 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.3 2.3 GO:0043457 regulation of cellular respiration(GO:0043457)
0.3 1.0 GO:0090295 nitrogen catabolite repression of transcription(GO:0090295)
0.3 2.5 GO:0051177 meiotic sister chromatid cohesion(GO:0051177)
0.3 0.9 GO:0015740 C4-dicarboxylate transport(GO:0015740)
0.3 11.6 GO:0070591 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
0.3 2.7 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.3 1.1 GO:0015847 putrescine transport(GO:0015847)
0.3 0.9 GO:0006545 glycine biosynthetic process(GO:0006545)
0.3 3.8 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.3 0.8 GO:0015888 thiamine transport(GO:0015888)
0.3 0.8 GO:0042710 biofilm formation(GO:0042710)
0.3 1.3 GO:0051180 vitamin transport(GO:0051180)
0.2 1.0 GO:0015809 arginine transport(GO:0015809)
0.2 0.5 GO:0051352 negative regulation of ligase activity(GO:0051352) negative regulation of ubiquitin-protein transferase activity(GO:0051444)
0.2 1.9 GO:0015891 siderophore transport(GO:0015891)
0.2 0.7 GO:0006741 NADP biosynthetic process(GO:0006741)
0.2 1.2 GO:0019660 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
0.2 0.9 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.2 0.9 GO:0043200 response to amino acid(GO:0043200)
0.2 1.9 GO:0000755 cytogamy(GO:0000755)
0.2 0.6 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.2 2.2 GO:0015893 drug transport(GO:0015893)
0.2 0.8 GO:0009229 thiamine diphosphate biosynthetic process(GO:0009229) thiamine diphosphate metabolic process(GO:0042357)
0.2 0.9 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.2 0.8 GO:0007070 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070) regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021)
0.2 0.8 GO:0032077 positive regulation of deoxyribonuclease activity(GO:0032077) positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.2 0.5 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.2 1.2 GO:0043605 cellular amide catabolic process(GO:0043605)
0.2 0.5 GO:0000916 actomyosin contractile ring contraction(GO:0000916) contractile ring contraction(GO:0036213)
0.2 1.9 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.2 0.8 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
0.2 0.8 GO:0043954 cellular component maintenance(GO:0043954)
0.2 0.5 GO:0000304 response to singlet oxygen(GO:0000304)
0.2 0.2 GO:0001666 response to hypoxia(GO:0001666) cellular response to hypoxia(GO:0071456)
0.2 0.8 GO:0051260 protein homooligomerization(GO:0051260)
0.2 1.1 GO:0034762 regulation of transmembrane transport(GO:0034762)
0.2 0.9 GO:0007050 cell cycle arrest(GO:0007050)
0.1 0.6 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.1 0.6 GO:0044783 G1 DNA damage checkpoint(GO:0044783)
0.1 1.3 GO:0031167 rRNA methylation(GO:0031167)
0.1 0.7 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.1 1.6 GO:0006817 phosphate ion transport(GO:0006817)
0.1 0.7 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.1 0.7 GO:0045764 positive regulation of cellular amino acid metabolic process(GO:0045764)
0.1 0.5 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.1 0.5 GO:0046688 response to copper ion(GO:0046688)
0.1 1.3 GO:0072348 sulfur compound transport(GO:0072348)
0.1 5.6 GO:0034293 sexual sporulation(GO:0034293) sexual sporulation resulting in formation of a cellular spore(GO:0043935)
0.1 0.6 GO:0034486 amino acid export(GO:0032973) amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.1 0.5 GO:1903137 inactivation of MAPK activity involved in cell wall organization or biogenesis(GO:0000200) regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903137) negative regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903138) negative regulation of cell wall organization or biogenesis(GO:1903339)
0.1 0.1 GO:1900544 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.1 0.3 GO:0034389 lipid particle organization(GO:0034389)
0.1 0.4 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.1 1.6 GO:0006098 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.1 1.3 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.1 1.5 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 1.4 GO:1905037 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.1 1.2 GO:0016925 protein sumoylation(GO:0016925)
0.1 0.4 GO:0046058 cAMP metabolic process(GO:0046058)
0.1 0.7 GO:0070987 error-free translesion synthesis(GO:0070987)
0.1 0.3 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.1 0.2 GO:0090399 replicative senescence(GO:0090399)
0.1 0.5 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.1 0.3 GO:0034501 protein localization to kinetochore(GO:0034501)
0.1 0.2 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.1 0.2 GO:0031507 heterochromatin assembly(GO:0031507)
0.1 0.3 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.1 0.4 GO:0009102 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.1 0.3 GO:0098610 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.1 0.3 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.1 0.4 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.1 1.6 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 0.5 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.1 0.4 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.1 0.3 GO:0034517 ribophagy(GO:0034517)
0.1 1.5 GO:0031503 protein complex localization(GO:0031503)
0.1 0.2 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.1 0.3 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.1 0.2 GO:0043007 maintenance of rDNA(GO:0043007)
0.1 1.0 GO:0042724 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.1 0.7 GO:0045910 negative regulation of DNA recombination(GO:0045910)
0.1 0.4 GO:0006537 glutamate biosynthetic process(GO:0006537)
0.1 0.3 GO:0007534 gene conversion at mating-type locus(GO:0007534)
0.1 0.6 GO:0000710 meiotic mismatch repair(GO:0000710)
0.1 0.1 GO:0010942 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.1 0.7 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.1 0.7 GO:0042766 nucleosome mobilization(GO:0042766)
0.1 0.3 GO:0006546 glycine catabolic process(GO:0006546)
0.1 0.3 GO:0006101 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101)
0.1 0.4 GO:0000266 mitochondrial fission(GO:0000266)
0.1 0.1 GO:0001198 regulation of mating-type specific transcription from RNA polymerase II promoter(GO:0001196) negative regulation of mating-type specific transcription from RNA polymerase II promoter(GO:0001198) negative regulation of mating-type specific transcription, DNA-templated(GO:0045894)
0.1 0.8 GO:0006513 protein monoubiquitination(GO:0006513)
0.1 0.3 GO:0070676 intralumenal vesicle formation(GO:0070676)
0.1 0.1 GO:0000078 obsolete cytokinesis after mitosis checkpoint(GO:0000078)
0.1 0.1 GO:0000019 regulation of mitotic recombination(GO:0000019)
0.1 0.3 GO:0006279 premeiotic DNA replication(GO:0006279)
0.1 0.1 GO:0006827 high-affinity iron ion transmembrane transport(GO:0006827)
0.1 0.2 GO:0090294 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
0.1 0.1 GO:0071248 cellular response to metal ion(GO:0071248)
0.1 0.5 GO:0019722 calcium-mediated signaling(GO:0019722)
0.1 0.2 GO:0000196 MAPK cascade involved in cell wall organization or biogenesis(GO:0000196)
0.1 0.1 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.1 0.4 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.1 0.2 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.1 0.1 GO:0015688 iron chelate transport(GO:0015688)
0.1 0.1 GO:0032075 positive regulation of nuclease activity(GO:0032075)
0.1 0.2 GO:0036010 protein localization to endosome(GO:0036010)
0.1 0.3 GO:0015793 glycerol transport(GO:0015793)
0.1 0.3 GO:0007019 microtubule depolymerization(GO:0007019)
0.1 0.2 GO:0071041 antisense RNA transcript catabolic process(GO:0071041)
0.0 0.1 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.0 0.4 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.2 GO:0006878 cellular copper ion homeostasis(GO:0006878) copper ion homeostasis(GO:0055070)
0.0 0.3 GO:0043629 ncRNA polyadenylation(GO:0043629)
0.0 0.2 GO:0019433 triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)
0.0 0.2 GO:0009410 response to xenobiotic stimulus(GO:0009410)
0.0 0.2 GO:0006611 protein export from nucleus(GO:0006611)
0.0 0.2 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.1 GO:0006282 regulation of DNA repair(GO:0006282)
0.0 0.2 GO:0000390 spliceosomal complex disassembly(GO:0000390)
0.0 0.4 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 1.7 GO:0043934 sporulation(GO:0043934)
0.0 0.2 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.6 GO:0034968 histone lysine methylation(GO:0034968)
0.0 0.1 GO:0034395 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.0 0.1 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.1 GO:0045895 positive regulation of mating-type specific transcription, DNA-templated(GO:0045895)
0.0 0.1 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.0 0.1 GO:0015976 carbon utilization(GO:0015976)
0.0 0.5 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.0 GO:1900151 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151)
0.0 0.2 GO:0022615 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0 0.5 GO:0015918 sterol transport(GO:0015918)
0.0 0.8 GO:0008645 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.0 0.3 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0 0.2 GO:0000753 cell morphogenesis involved in conjugation with cellular fusion(GO:0000753)
0.0 0.1 GO:0072530 cytosine transport(GO:0015856) purine-containing compound transmembrane transport(GO:0072530)
0.0 0.0 GO:0006119 oxidative phosphorylation(GO:0006119) respiratory electron transport chain(GO:0022904) ATP synthesis coupled electron transport(GO:0042773) mitochondrial ATP synthesis coupled electron transport(GO:0042775)
0.0 0.3 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.2 GO:0042791 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791)
0.0 0.0 GO:1902931 negative regulation of alcohol biosynthetic process(GO:1902931)
0.0 0.5 GO:0030261 chromosome condensation(GO:0030261)
0.0 0.1 GO:0051126 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) negative regulation of actin nucleation(GO:0051126)
0.0 0.1 GO:0006598 polyamine catabolic process(GO:0006598)
0.0 0.0 GO:0015855 pyrimidine nucleobase transport(GO:0015855)
0.0 0.1 GO:0000409 regulation of transcription by galactose(GO:0000409) positive regulation of transcription by galactose(GO:0000411)
0.0 0.1 GO:0070096 mitochondrial outer membrane translocase complex assembly(GO:0070096)
0.0 0.2 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.5 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.3 GO:0015914 phospholipid transport(GO:0015914)
0.0 1.1 GO:0006631 fatty acid metabolic process(GO:0006631)
0.0 0.3 GO:0034965 intronic snoRNA processing(GO:0031070) intronic box C/D snoRNA processing(GO:0034965)
0.0 0.4 GO:0000742 karyogamy involved in conjugation with cellular fusion(GO:0000742)
0.0 0.1 GO:0015691 cadmium ion transport(GO:0015691)
0.0 0.1 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 0.1 GO:0016241 regulation of macroautophagy(GO:0016241)
0.0 0.1 GO:0044209 AMP salvage(GO:0044209)
0.0 0.1 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 1.0 GO:0007124 pseudohyphal growth(GO:0007124)
0.0 0.0 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 1.0 GO:0071427 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0 0.1 GO:0000963 mitochondrial RNA processing(GO:0000963)
0.0 0.1 GO:0046036 CTP biosynthetic process(GO:0006241) pyrimidine ribonucleoside triphosphate metabolic process(GO:0009208) pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209) CTP metabolic process(GO:0046036)
0.0 0.0 GO:0006641 neutral lipid metabolic process(GO:0006638) acylglycerol metabolic process(GO:0006639) triglyceride metabolic process(GO:0006641)
0.0 0.1 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.1 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.0 0.1 GO:0046113 nucleobase catabolic process(GO:0046113)
0.0 0.1 GO:0070124 mitochondrial translational initiation(GO:0070124)
0.0 0.1 GO:0051469 vesicle fusion with vacuole(GO:0051469)
0.0 0.2 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.1 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.0 0.1 GO:0016233 telomere capping(GO:0016233)
0.0 0.1 GO:0006449 regulation of translational termination(GO:0006449)
0.0 0.1 GO:0018063 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.0 0.2 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0 0.2 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.0 0.3 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.0 0.0 GO:1903313 positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0 0.2 GO:0042327 positive regulation of phosphorylation(GO:0042327)
0.0 0.1 GO:0000023 maltose metabolic process(GO:0000023)
0.0 0.1 GO:0016562 receptor recycling(GO:0001881) protein import into peroxisome matrix, receptor recycling(GO:0016562) receptor metabolic process(GO:0043112)
0.0 0.1 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.0 0.0 GO:0001308 negative regulation of chromatin silencing involved in replicative cell aging(GO:0001308)
0.0 0.1 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0 0.4 GO:0030466 chromatin silencing at silent mating-type cassette(GO:0030466)
0.0 0.1 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.0 GO:0006592 ornithine biosynthetic process(GO:0006592)
0.0 0.1 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.0 0.2 GO:0033617 respiratory chain complex IV assembly(GO:0008535) mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.0 0.2 GO:0006378 mRNA polyadenylation(GO:0006378)
0.0 0.1 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.1 GO:0016575 histone deacetylation(GO:0016575)
0.0 0.0 GO:0051259 protein oligomerization(GO:0051259)
0.0 0.0 GO:0006740 NADPH regeneration(GO:0006740)
0.0 0.1 GO:0031145 anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.0 0.1 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 13.9 GO:0031160 spore wall(GO:0031160)
0.6 2.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.5 2.2 GO:0033551 monopolin complex(GO:0033551)
0.4 4.6 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.3 1.0 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.3 7.5 GO:0005628 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.3 0.8 GO:0005756 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
0.3 1.1 GO:0097002 mitochondrial inner boundary membrane(GO:0097002)
0.3 0.8 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.2 0.7 GO:0000417 HIR complex(GO:0000417)
0.2 0.6 GO:0045265 mitochondrial proton-transporting ATP synthase, stator stalk(GO:0000274) proton-transporting ATP synthase, stator stalk(GO:0045265)
0.2 0.6 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.2 0.5 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.2 1.6 GO:0045277 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.2 1.7 GO:0030677 ribonuclease P complex(GO:0030677)
0.2 0.7 GO:0030892 mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990)
0.2 1.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.2 1.1 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.2 0.5 GO:0051286 cell tip(GO:0051286)
0.1 0.7 GO:0045257 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.1 0.6 GO:0000817 COMA complex(GO:0000817)
0.1 0.8 GO:0032126 eisosome(GO:0032126)
0.1 0.8 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.1 1.0 GO:0000795 synaptonemal complex(GO:0000795)
0.1 1.5 GO:0070469 respiratory chain(GO:0070469)
0.1 0.2 GO:0009353 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.1 0.6 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.1 0.1 GO:0044453 nuclear membrane part(GO:0044453)
0.1 0.2 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 0.4 GO:0031931 TORC1 complex(GO:0031931)
0.1 0.3 GO:0097042 extrinsic component of fungal-type vacuolar membrane(GO:0097042)
0.1 0.3 GO:0005960 glycine cleavage complex(GO:0005960)
0.1 0.8 GO:0031011 Ino80 complex(GO:0031011)
0.1 0.3 GO:0000815 ESCRT III complex(GO:0000815)
0.1 0.3 GO:0005771 multivesicular body(GO:0005771)
0.1 2.7 GO:0031225 anchored component of membrane(GO:0031225)
0.1 1.0 GO:0031307 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.1 0.3 GO:0031262 Ndc80 complex(GO:0031262)
0.1 0.5 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.1 0.2 GO:0035649 Nrd1 complex(GO:0035649)
0.0 0.3 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.2 GO:0000446 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) nucleoplasmic THO complex(GO:0000446)
0.0 0.5 GO:0000142 cellular bud neck contractile ring(GO:0000142)
0.0 0.1 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.0 1.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.3 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.0 0.3 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.1 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0 0.5 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.2 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.1 GO:0030122 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128) endocytic vesicle(GO:0030139) endocytic vesicle membrane(GO:0030666) clathrin-coated endocytic vesicle membrane(GO:0030669) clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.2 GO:0031499 TRAMP complex(GO:0031499)
0.0 0.1 GO:0032389 MutLalpha complex(GO:0032389)
0.0 0.2 GO:0017119 Golgi transport complex(GO:0017119)
0.0 4.5 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.1 GO:0016587 Isw1 complex(GO:0016587)
0.0 0.4 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.1 GO:0044233 ERMES complex(GO:0032865) ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.0 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.1 GO:0000974 Prp19 complex(GO:0000974)
0.0 0.1 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.1 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.1 GO:0051233 spindle midzone(GO:0051233)
0.0 0.1 GO:0005825 half bridge of spindle pole body(GO:0005825)
0.0 0.0 GO:0005845 mRNA cap binding complex(GO:0005845)
0.0 1.0 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 0.4 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.2 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.0 1.0 GO:0010008 endosome membrane(GO:0010008)
0.0 0.2 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.1 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.0 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.2 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.1 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.1 GO:0005770 late endosome(GO:0005770)
0.0 0.1 GO:1902555 endoribonuclease complex(GO:1902555)
0.0 0.2 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.1 GO:0034967 Set3 complex(GO:0034967)
0.0 0.0 GO:0033100 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.0 0.1 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.0 GO:0008275 gamma-tubulin small complex, spindle pole body(GO:0000928) gamma-tubulin complex(GO:0000930) gamma-tubulin small complex(GO:0008275)
0.0 0.1 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.4 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.0 0.6 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.6 GO:0005643 nuclear pore(GO:0005643)
0.0 0.1 GO:0090544 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.2 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
1.0 4.1 GO:0005537 mannose binding(GO:0005537)
0.7 2.2 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
0.6 3.6 GO:0005354 galactose transmembrane transporter activity(GO:0005354)
0.6 2.3 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.4 1.3 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.4 1.2 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
0.3 1.7 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.3 1.3 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.3 1.3 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.3 1.0 GO:0008137 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.3 1.3 GO:0015343 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.3 1.8 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.3 2.1 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.2 4.9 GO:0015297 antiporter activity(GO:0015297)
0.2 0.7 GO:0008972 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.2 0.7 GO:0042736 NAD+ kinase activity(GO:0003951) NADH kinase activity(GO:0042736)
0.2 0.7 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
0.2 1.3 GO:0051183 vitamin transporter activity(GO:0051183)
0.2 0.6 GO:0070569 uridylyltransferase activity(GO:0070569)
0.2 0.4 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.2 0.6 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.2 0.5 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.2 0.5 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.2 4.1 GO:0005484 SNAP receptor activity(GO:0005484)
0.2 1.7 GO:0004526 ribonuclease P activity(GO:0004526)
0.2 3.2 GO:0019213 deacetylase activity(GO:0019213)
0.2 0.5 GO:0032183 SUMO binding(GO:0032183)
0.2 1.6 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 1.2 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 0.4 GO:0048038 quinone binding(GO:0048038)
0.1 0.6 GO:0015295 solute:proton symporter activity(GO:0015295)
0.1 0.4 GO:0003680 AT DNA binding(GO:0003680)
0.1 1.2 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.1 6.1 GO:0001228 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 0.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 2.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 0.4 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 0.5 GO:0000156 phosphorelay response regulator activity(GO:0000156)
0.1 1.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 0.3 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.1 1.2 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.1 0.7 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 0.7 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 0.1 GO:0042947 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.1 0.9 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
0.1 0.3 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177) oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.1 0.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 0.5 GO:0016408 C-acyltransferase activity(GO:0016408)
0.1 1.1 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.1 1.5 GO:0020037 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.1 0.5 GO:0016783 sulfurtransferase activity(GO:0016783)
0.1 0.4 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.1 0.4 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.1 0.2 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.1 0.5 GO:0015293 symporter activity(GO:0015293)
0.1 0.4 GO:0019789 SUMO transferase activity(GO:0019789)
0.1 0.2 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 1.4 GO:0005507 copper ion binding(GO:0005507)
0.1 0.4 GO:0015248 sterol transporter activity(GO:0015248)
0.1 0.3 GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813)
0.1 0.1 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.1 0.3 GO:0015203 polyamine transmembrane transporter activity(GO:0015203)
0.1 0.3 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.1 0.2 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025) TFIIIC-class transcription factor binding(GO:0001156)
0.1 0.3 GO:0004375 glycine dehydrogenase (decarboxylating) activity(GO:0004375) oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor(GO:0016642)
0.1 0.2 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 0.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 0.2 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.1 0.7 GO:0030983 mismatched DNA binding(GO:0030983)
0.1 0.3 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.1 0.2 GO:0001128 RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly(GO:0001128)
0.1 0.2 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.1 0.3 GO:0015079 potassium ion transmembrane transporter activity(GO:0015079)
0.1 0.3 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.1 0.2 GO:0001097 RNA polymerase II basal transcription factor binding(GO:0001091) TFIIH-class transcription factor binding(GO:0001097)
0.1 0.4 GO:0031072 heat shock protein binding(GO:0031072)
0.1 0.3 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.1 0.3 GO:0000146 microfilament motor activity(GO:0000146)
0.1 0.1 GO:0045118 azole transporter activity(GO:0045118)
0.1 0.5 GO:0030295 protein kinase activator activity(GO:0030295)
0.0 0.9 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.4 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.2 GO:0004806 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.0 0.2 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.7 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.2 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 2.2 GO:0022804 active transmembrane transporter activity(GO:0022804)
0.0 0.1 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.0 0.2 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.0 0.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.0 0.1 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
0.0 0.7 GO:0043022 ribosome binding(GO:0043022)
0.0 0.7 GO:0036459 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 0.3 GO:0000149 SNARE binding(GO:0000149)
0.0 0.2 GO:0019238 cyclohydrolase activity(GO:0019238)
0.0 0.7 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.3 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 0.4 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.0 0.3 GO:0031386 protein tag(GO:0031386)
0.0 0.1 GO:0008172 S-methyltransferase activity(GO:0008172)
0.0 0.5 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.3 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.1 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0 0.1 GO:0016417 S-acyltransferase activity(GO:0016417)
0.0 0.1 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.0 0.2 GO:0038023 transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) transmembrane receptor activity(GO:0099600)
0.0 0.1 GO:0015658 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.0 0.1 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.6 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.4 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.1 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0 0.1 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0 0.1 GO:0015077 monovalent inorganic cation transmembrane transporter activity(GO:0015077)
0.0 0.1 GO:0016289 CoA hydrolase activity(GO:0016289)
0.0 1.4 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 0.1 GO:0042124 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.0 0.1 GO:0004396 hexokinase activity(GO:0004396)
0.0 0.2 GO:0000293 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.0 0.3 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 0.1 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.0 0.1 GO:0004629 phospholipase C activity(GO:0004629)
0.0 2.2 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 0.1 GO:0000772 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.0 0.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.0 0.2 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.2 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.1 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.0 GO:0003840 gamma-glutamyltransferase activity(GO:0003840)
0.0 0.0 GO:0004458 lactate dehydrogenase activity(GO:0004457) D-lactate dehydrogenase (cytochrome) activity(GO:0004458) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
0.0 0.1 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.0 0.1 GO:0004549 tRNA-specific ribonuclease activity(GO:0004549)
0.0 0.2 GO:0051087 chaperone binding(GO:0051087)
0.0 0.5 GO:0016773 phosphotransferase activity, alcohol group as acceptor(GO:0016773)
0.0 0.0 GO:0016530 metallochaperone activity(GO:0016530)
0.0 0.1 GO:0017022 myosin binding(GO:0017022)
0.0 0.0 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.3 0.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 0.2 PID ERBB4 PATHWAY ErbB4 signaling events
0.1 0.2 PID ATM PATHWAY ATM pathway
0.0 0.3 NABA MATRISOME ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.0 49.0 PID TELOMERASE PATHWAY Regulation of Telomerase

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.4 1.1 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.3 1.0 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.2 0.7 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 0.3 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 0.2 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 0.6 REACTOME MEIOSIS Genes involved in Meiosis
0.1 0.1 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 0.2 REACTOME HEMOSTASIS Genes involved in Hemostasis
0.0 0.3 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 48.1 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.1 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.0 0.1 REACTOME RNA POL II PRE TRANSCRIPTION EVENTS Genes involved in RNA Polymerase II Pre-transcription Events