Results for CUP9
Z-value: 0.98
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Transcription factors associated with CUP9
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
CUP9
|
S000006098 | Homeodomain-containing transcriptional repressor |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YMR017W Show fit | 4.61 |
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog |
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| YGR087C Show fit | 4.20 |
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation |
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| YHR139C Show fit | 3.32 |
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall |
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| YOR100C Show fit | 3.10 |
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation |
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| YMR107W Show fit | 2.93 |
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources |
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| YGR059W Show fit | 2.86 |
Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI |
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| YOR255W Show fit | 2.62 |
Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p |
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| YIL057C Show fit | 2.55 |
Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose |
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| YFL011W Show fit | 2.51 |
Putative hexose transporter, expressed at low levels and expression is repressed by glucose |
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| YER065C Show fit | 2.50 |
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose |
Network of associatons between targets according to the STRING database.
First level regulatory network of CUP9
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 11.6 | GO:0070591 | ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940) |
| 0.1 | 5.6 | GO:0034293 | sexual sporulation(GO:0034293) sexual sporulation resulting in formation of a cellular spore(GO:0043935) |
| 0.5 | 4.8 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 0.7 | 4.5 | GO:0000501 | flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501) |
| 1.1 | 4.2 | GO:0000949 | aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949) |
| 0.3 | 3.8 | GO:0031321 | ascospore-type prospore assembly(GO:0031321) |
| 0.3 | 2.7 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.3 | 2.5 | GO:0051177 | meiotic sister chromatid cohesion(GO:0051177) |
| 0.5 | 2.4 | GO:0006032 | aminoglycan catabolic process(GO:0006026) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072) |
| 0.3 | 2.3 | GO:0043457 | regulation of cellular respiration(GO:0043457) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 13.9 | GO:0031160 | spore wall(GO:0031160) |
| 0.3 | 7.5 | GO:0005628 | prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764) |
| 0.4 | 4.6 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 4.5 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 2.7 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.6 | 2.4 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.5 | 2.2 | GO:0033551 | monopolin complex(GO:0033551) |
| 0.2 | 1.7 | GO:0030677 | ribonuclease P complex(GO:0030677) |
| 0.2 | 1.6 | GO:0045277 | mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277) |
| 0.1 | 1.5 | GO:0070469 | respiratory chain(GO:0070469) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.1 | GO:0001228 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.2 | 4.9 | GO:0015297 | antiporter activity(GO:0015297) |
| 1.1 | 4.2 | GO:0004737 | pyruvate decarboxylase activity(GO:0004737) |
| 1.0 | 4.1 | GO:0005537 | mannose binding(GO:0005537) |
| 0.2 | 4.1 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.6 | 3.6 | GO:0005354 | galactose transmembrane transporter activity(GO:0005354) |
| 0.2 | 3.2 | GO:0019213 | deacetylase activity(GO:0019213) |
| 0.6 | 2.3 | GO:0016639 | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639) |
| 0.7 | 2.2 | GO:0004092 | carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406) |
| 0.0 | 2.2 | GO:0022804 | active transmembrane transporter activity(GO:0022804) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 49.0 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.4 | 1.6 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.3 | 0.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 0.3 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.1 | 0.2 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.1 | 0.2 | PID ATM PATHWAY | ATM pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 48.1 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.6 | 1.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.4 | 1.1 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.3 | 1.0 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.2 | 0.7 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.1 | 0.6 | REACTOME MEIOSIS | Genes involved in Meiosis |
| 0.1 | 0.3 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.0 | 0.3 | REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX | Genes involved in Association of licensing factors with the pre-replicative complex |
| 0.1 | 0.2 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.1 | 0.2 | REACTOME HEMOSTASIS | Genes involved in Hemostasis |