Results for CUP2
Z-value: 1.23
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Transcription factors associated with CUP2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
CUP2
|
S000003134 | Copper-binding transcription factor |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YLR307C-A Show fit | 14.98 |
Putative protein of unknown function |
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| YHR053C Show fit | 14.53 |
Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C |
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| YHR055C Show fit | 14.20 |
Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C |
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| YAR053W Show fit | 13.42 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
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| YMR107W Show fit | 12.83 |
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources |
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| YIL057C Show fit | 11.12 |
Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose |
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| YHR054W-A Show fit | 10.72 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CUP1-2 |
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| YJL089W Show fit | 10.53 |
C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus |
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| YAR060C Show fit | 9.86 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
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| YMR244W Show fit | 9.24 |
Putative protein of unknown function |
Network of associatons between targets according to the STRING database.
First level regulatory network of CUP2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.3 | 29.2 | GO:0046688 | response to copper ion(GO:0046688) |
| 2.1 | 16.6 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 4.4 | 13.3 | GO:0035948 | regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414) |
| 0.8 | 12.6 | GO:0019682 | pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682) |
| 1.2 | 10.7 | GO:0045721 | negative regulation of gluconeogenesis(GO:0045721) |
| 0.7 | 9.7 | GO:0008645 | hexose transport(GO:0008645) monosaccharide transport(GO:0015749) |
| 1.2 | 9.3 | GO:0005987 | sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987) |
| 3.0 | 9.1 | GO:0015755 | fructose transport(GO:0015755) |
| 2.2 | 8.9 | GO:0006848 | pyruvate transport(GO:0006848) |
| 1.1 | 8.9 | GO:0015758 | glucose transport(GO:0015758) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.5 | GO:0005886 | plasma membrane(GO:0005886) |
| 0.3 | 16.2 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.1 | 13.0 | GO:0000322 | storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324) |
| 0.3 | 12.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 11.6 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 1.0 | 8.7 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.2 | 8.5 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.7 | 8.3 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 1.1 | 8.0 | GO:0034657 | GID complex(GO:0034657) |
| 0.5 | 6.9 | GO:0005619 | ascospore wall(GO:0005619) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.8 | 28.8 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 4.1 | 20.5 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 0.3 | 16.1 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.9 | 12.0 | GO:0015578 | fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578) |
| 3.9 | 11.6 | GO:0036440 | citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440) |
| 2.4 | 9.6 | GO:0004396 | hexokinase activity(GO:0004396) |
| 2.2 | 8.9 | GO:0005537 | mannose binding(GO:0005537) |
| 1.4 | 8.4 | GO:0016744 | transferase activity, transferring aldehyde or ketonic groups(GO:0016744) |
| 2.8 | 8.3 | GO:0004564 | beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575) |
| 0.4 | 7.6 | GO:0008483 | transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 235.1 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 1.8 | 5.5 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 1.2 | 3.7 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.5 | 1.5 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.2 | 0.9 | PID AVB3 INTEGRIN PATHWAY | Integrins in angiogenesis |
| 0.3 | 0.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 0.8 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.2 | 0.7 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.1 | 0.5 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.4 | 0.4 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 232.7 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 2.7 | 8.2 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.4 | 2.8 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.5 | 2.1 | REACTOME DOUBLE STRAND BREAK REPAIR | Genes involved in Double-Strand Break Repair |
| 0.3 | 2.0 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.3 | 1.4 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.3 | 1.4 | REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM | Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism |
| 0.1 | 1.1 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.2 | 0.4 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 0.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |