Navigation
Downloads

Results for CST6

Z-value: 1.12

Motif logo

logo of

Transcription factors associated with CST6

Gene Symbol Gene ID Gene Info
CST6
S000001298 Basic leucine zipper (bZIP) transcription factor, in ATF/CREB family

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
CST6YIL036W-0.861.7e-08Click!

Activity profile of CST6 motif

Sorted Z-values of CST6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YHR094C 13.12
HXT1
Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YFR055W 9.94
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YGR052W 8.48
FMP48
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
YFR056C 8.24 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YNL178W 7.42
RPS3
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YLR413W 6.89 Putative protein of unknown function; YLR413W is not an essential gene
YJR009C 6.51
TDH2
Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
YLR154C 6.17
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YLR154W-B 6.16 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YLR154W-A 6.07 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YGR050C 6.04 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR509W 5.84 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR508C 5.81
GNP1
High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids
YMR083W 5.72
ADH3
Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YDR044W 5.41
HEM13
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YJR094W-A 5.06
RPL43B
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YBR158W 4.60
AMN1
Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YGR051C 4.36 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene
YHR181W 3.96
SVP26
Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YGL157W 3.90 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YCR018C 3.87
SRD1
Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YHR089C 3.86
GAR1
Protein component of the H/ACA snoRNP pseudouridylase complex, involved in the modification and cleavage of the 18S pre-rRNA
YGR108W 3.77
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YNR016C 3.76
ACC1
Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids
YFL022C 3.67
FRS2
Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
YDR033W 3.66
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YAL038W 3.54
CDC19
Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration
YJR010W 3.37
MET3
ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism
YMR144W 3.31 Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene
YHR174W 3.30
ENO2
Enolase II, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is induced in response to glucose
YKR038C 3.25
KAE1
Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex
YDR041W 3.25
RSM10
Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
YGR086C 3.24
PIL1
Primary component of eisosomes, which are large immobile cell cortex structures associated with endocytosis; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria
YKL060C 3.12
FBA1
Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress
YJL158C 3.04
CIS3
Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
YKL219W 3.04
COS9
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YOR317W 2.80
FAA1
Long chain fatty acyl-CoA synthetase with a preference for C12:0-C16:0 fatty acids; involved in the activation of imported fatty acids; localized to both lipid particles and mitochondrial outer membrane; essential for stationary phase
YPL250W-A 2.79 Identified by fungal homology and RT-PCR
YMR318C 2.78
ADH6
NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance
YJR145C 2.77
RPS4A
Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein
YPR170W-B 2.74 Putative protein of unknown function, conserved in fungi; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C
YER055C 2.71
HIS1
ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
YJL011C 2.68
RPC17
RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex
YJL167W 2.68
ERG20
Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis
YKL128C 2.64
PMU1
Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
YOL101C 2.62
IZH4
Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism
YDR040C 2.61
ENA1
P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance
YDR098C 2.59
GRX3
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YDR133C 2.59 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YLR042C 2.58 Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene
YLR286C 2.57
CTS1
Endochitinase, required for cell separation after mitosis; transcriptional activation during late G and early M cell cycle phases is mediated by transcription factor Ace2p
YPR119W 2.56
CLB2
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YDL205C 2.54
HEM3
Phorphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p
YEL056W 2.43
HAT2
Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing
YIL053W 2.43
RHR2
Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress
YML026C 2.41
RPS18B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Ap and has similarity to E. coli S13 and rat S18 ribosomal proteins
YDR471W 2.38
RPL27B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Ap and has similarity to rat L27 ribosomal protein
YMR202W 2.33
ERG2
C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis
YER006W 2.32
NUG1
GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus
YER036C 2.31
ARB1
ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p
YJR070C 2.31
LIA1
Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyses hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning
YKL218C 2.29
SRY1
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YHR180W-A 2.26 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3
YBR112C 2.25
CYC8
General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters
YJR001W 2.25
AVT1
Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YER124C 2.22
DSE1
Daughter cell-specific protein, may participate in pathways regulating cell wall metabolism; deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall
YER131W 2.22
RPS26B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YLR328W 2.22
NMA1
Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways
YLR180W 2.17
SAM1
S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YJR071W 2.16 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNR054C 2.16
ESF2
Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
YDR465C 2.15
RMT2
Arginine methyltransferase; ribosomal protein L12 is a substrate
YGR040W 2.15
KSS1
Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
YLR154W-C 2.15
TAR1
Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YOR376W-A 2.12 Putative protein of unknown function; identified by fungal homology and RT-PCR
YMR082C 2.12 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR032W-A 2.10 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YHR032C-A
YLR109W 2.09
AHP1
Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p
YGR020C 2.08
VMA7
Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
YKL164C 2.07
PIR1
O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle
YNL327W 2.07
EGT2
Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner
YPL075W 2.04
GCR1
Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p
YKL127W 2.03
PGM1
Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism
YOL127W 2.02
RPL25
Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 26S rRNA via a conserved C-terminal motif
YKL096W-A 2.01
CWP2
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YGR255C 1.97
COQ6
Putative flavin-dependent monooxygenase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes
YOR342C 1.96 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YMR303C 1.96
ADH2
Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1
YBR126W-A 1.94 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR126W-B; identified by gene-trapping, microarray analysis, and genome-wide homology searches
YGR249W 1.94
MGA1
Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants
YBR118W 1.92
TEF2
Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes
YDL055C 1.92
PSA1
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YDL084W 1.91
SUB2
Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56
YIL052C 1.91
RPL34B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Ap and has similarity to rat L34 ribosomal protein
YML074C 1.88
FPR3
Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
YEL068C 1.87 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR316C-A 1.84 Putative protein of unknown function; identified by fungal homology and RT-PCR
YCL024W 1.84
KCC4
Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p
YBR104W 1.84
YMC2
Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p
YGR148C 1.84
RPL24B
Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YLR351C 1.83
NIT3
Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member
YIR021W 1.83
MRS1
Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YKR013W 1.81
PRY2
Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins
YLR150W 1.79
STM1
Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations
YPR170W-A 1.79 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry
YBR162C 1.79
TOS1
Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C
YBR113W 1.77 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8
YNL043C 1.76 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
YMR011W 1.76
HXT2
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YGL097W 1.76
SRM1
Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
YEL066W 1.75
HPA3
D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro
YGL055W 1.74
OLE1
Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
YKR092C 1.72
SRP40
Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YKL120W 1.71
OAC1
Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, and thiosulfate; member of the mitochondrial carrier family
YLR029C 1.71
RPL15A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Bp and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA
YPL265W 1.70
DIP5
Dicarboxylic amino acid permease, mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly
YNL035C 1.70 Putative protein of unknown function with similarity to proteins containing WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene
YNR072W 1.69
HXT17
Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose
YOR025W 1.68
HST3
Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
YLR333C 1.66
RPS25B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Ap and has similarity to rat S25 ribosomal protein
YCL023C 1.65 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4
YNR017W 1.64
TIM23
Essential protein of the mitochondrial inner membrane, component of the mitochondrial import system
YCL027W 1.61
FUS1
Membrane protein localized to the shmoo tip, required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate
YFL015C 1.61 Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
YER048W-A 1.61
ISD11
Protein required for mitochondrial iron-sulfur cluster biosynthesis
YFR032C 1.61 Putative protein of unknown function; transcribed during sporulation; YFR032C is not an essential gene
YGR251W 1.60 Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YFR054C 1.60 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR375C 1.59
GDH1
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources
YOR247W 1.57
SRL1
Mannoprotein that exhibits a tight association with the cell wall, required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants
YOR092W 1.57
ECM3
Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation
YGR159C 1.56
NSR1
Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
YOR063W 1.54
RPL3
Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus
YOL031C 1.53
SIL1
Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein
YER134C 1.53 Putative protein of unknown function; non-essential gene
YER048C 1.51
CAJ1
Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly
YGL255W 1.51
ZRT1
High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YNL024C 1.51 Putative protein of unknown function with seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL024C is not an essential gene
YNL175C 1.49
NOP13
Protein of unknown function, localizes to the nucleolus and nucleoplasm; contains an RNA recognition motif (RRM) and has similarity to Nop12p, which is required for processing of pre-18S rRNA
YDR534C 1.47
FIT1
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YOR277C 1.46 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20
YOR167C 1.46
RPS28A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps28Bp and has similarity to rat S28 ribosomal protein
YGL009C 1.45
LEU1
Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway
YFL015W-A 1.45 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR448W 1.45
RPL6B
Protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Ap and to rat L6 ribosomal protein; binds to 5.8S rRNA
YKR012C 1.44 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2
YIL118W 1.44
RHO3
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YGL225W 1.44
VRG4
Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi
YPR148C 1.43 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YOL136C 1.42
PFK27
6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A
YLR325C 1.41
RPL38
Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein
YKL068W-A 1.40 Putative protein of unknown function; identified by homology to Ashbya gossypii
YDR119W 1.38
VBA4
Protein of unknown function with proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene
YDR072C 1.38
IPT1
Inositolphosphotransferase 1, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), which is the most abundant sphingolipid in cells, mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media
YDR210W 1.38 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YDR502C 1.37
SAM2
S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YGR152C 1.37
RSR1
GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases
YBL024W 1.36
NCL1
S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; similar to Nop2p and human proliferation associated nucleolar protein p120
YLR406C 1.35
RPL31B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Ap and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p
YBR126C 1.34
TPS1
Synthase subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway
YCR034W 1.34
FEN1
Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway
YMR121C 1.33
RPL15B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Ap and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA
YNL189W 1.32
SRP1
Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation
YPL177C 1.32
CUP9
Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription
YBR143C 1.32
SUP45
Polypeptide release factor involved in translation termination; mutant form acts as a recessive omnipotent suppressor
YDR353W 1.31
TRR1
Cytoplasmic thioredoxin reductase, key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress
YDR190C 1.30
RVB1
Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; member of the RUVB-like protein family
YOR361C 1.29
PRT1
Subunit of the core complex of translation initiation factor 3(eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes
YDL201W 1.28
TRM8
Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA
YOL124C 1.28
TRM11
Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
YKL033W-A 1.28 Putative protein of unknown function; similar to uncharacterized proteins from other fungi
YDR240C 1.28
SNU56
Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex
YER102W 1.28
RPS8B
Protein component of the small (40S) ribosomal subunit; identical to Rps8Ap and has similarity to rat S8 ribosomal protein
YGL105W 1.27
ARC1
Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids
YKL096W 1.26
CWP1
Cell wall mannoprotein, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; involved in cell wall organization
YHR173C 1.26 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR344W 1.26
RPL26A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Bp and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA
YPL178W 1.25
CBC2
Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif
YHR031C 1.25
RRM3
DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p
YDR267C 1.24
CIA1
Essential protein involved in assembly of cytosolic and nuclear iron-sulfur proteins
YER074W 1.24
RPS24A
Protein component of the small (40S) ribosomal subunit; identical to Rps24Bp and has similarity to rat S24 ribosomal protein
YKR056W 1.24
TRM2
tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair
YLR089C 1.23
ALT1
Putative alanine transaminase (glutamic pyruvic transaminase); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJL168C 1.23
SET2
Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
YPR170C 1.22 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B
YLR108C 1.21 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene
YOR028C 1.19
CIN5
Basic leucine zipper transcriptional factor of the yAP-1 family that mediates pleiotropic drug resistance and salt tolerance; localizes constitutively to the nucleus
YML088W 1.19
UFO1
F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation
YLR179C 1.19 Protein of unknown function, transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus; YLR179C is not essential
YER136W 1.19
GDI1
GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins
YGL020C 1.17
GET1
Subunit of the GET complex; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance
YEL067C 1.16 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNL338W 1.15 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV
YHL028W 1.15
WSC4
ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3
YBR249C 1.15
ARO4
3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan
YIL076W 1.15
SEC28
Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth
YHL003C 1.14
LAG1
Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p
YLR435W 1.13
TSR2
Protein with a potential role in pre-rRNA processing
YKL008C 1.12
LAC1
Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p
YGL253W 1.12
HXK2
Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene

Network of associatons between targets according to the STRING database.

First level regulatory network of CST6

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 9.4 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
1.7 6.8 GO:0035337 fatty-acyl-CoA metabolic process(GO:0035337)
1.2 3.7 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
1.2 3.6 GO:2000877 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
1.2 8.1 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
1.2 3.5 GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)(GO:0019379) sulfate reduction(GO:0019419)
1.1 3.4 GO:0009298 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
1.1 8.0 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
1.0 8.1 GO:0015758 glucose transport(GO:0015758)
1.0 10.6 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.9 3.5 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
0.8 5.8 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
0.8 2.5 GO:0006114 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.8 4.1 GO:0045338 terpenoid metabolic process(GO:0006721) terpenoid biosynthetic process(GO:0016114) farnesyl diphosphate biosynthetic process(GO:0045337) farnesyl diphosphate metabolic process(GO:0045338)
0.8 2.3 GO:0018216 peptidyl-arginine modification(GO:0018195) peptidyl-arginine methylation(GO:0018216)
0.7 0.7 GO:0045901 positive regulation of translational elongation(GO:0045901)
0.7 19.4 GO:0006757 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.7 2.0 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.6 6.2 GO:0006116 NADH oxidation(GO:0006116)
0.6 3.5 GO:0070941 eisosome assembly(GO:0070941)
0.6 2.3 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.6 2.8 GO:0060491 regulation of cell projection organization(GO:0031344) regulation of mating projection assembly(GO:0031383) regulation of cell projection assembly(GO:0060491)
0.5 9.3 GO:0006407 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
0.5 3.8 GO:0040031 snRNA pseudouridine synthesis(GO:0031120) snRNA modification(GO:0040031)
0.5 1.0 GO:0019287 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490)
0.5 3.5 GO:0009312 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.5 1.0 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.4 1.3 GO:0008272 sulfate transport(GO:0008272)
0.4 4.8 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
0.4 1.3 GO:0033559 unsaturated fatty acid biosynthetic process(GO:0006636) unsaturated fatty acid metabolic process(GO:0033559)
0.4 2.1 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.4 1.3 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
0.4 2.1 GO:0032233 regulation of actin filament bundle assembly(GO:0032231) positive regulation of actin filament bundle assembly(GO:0032233)
0.4 2.9 GO:0009098 leucine biosynthetic process(GO:0009098)
0.4 2.1 GO:0007188 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger(GO:0007187) adenylate cyclase-modulating G-protein coupled receptor signaling pathway(GO:0007188)
0.4 1.7 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
0.4 1.2 GO:0043069 negative regulation of apoptotic process(GO:0043066) negative regulation of programmed cell death(GO:0043069) negative regulation of cell death(GO:0060548)
0.4 3.7 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.4 5.6 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.4 1.6 GO:0030497 fatty acid elongation(GO:0030497)
0.4 1.6 GO:0009423 chorismate biosynthetic process(GO:0009423)
0.4 3.4 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.4 1.5 GO:0010674 negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010674)
0.4 1.1 GO:0006798 polyphosphate catabolic process(GO:0006798)
0.4 1.8 GO:0015780 nucleotide-sugar transport(GO:0015780)
0.3 1.7 GO:0006829 zinc II ion transport(GO:0006829)
0.3 2.4 GO:0046513 ceramide metabolic process(GO:0006672) ceramide biosynthetic process(GO:0046513)
0.3 1.7 GO:2000758 positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.3 3.0 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.3 1.0 GO:1901351 regulation of phosphatidylglycerol biosynthetic process(GO:1901351) negative regulation of phosphatidylglycerol biosynthetic process(GO:1901352)
0.3 1.3 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.3 1.3 GO:0006048 UDP-N-acetylglucosamine metabolic process(GO:0006047) UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.3 2.8 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.3 1.6 GO:0006166 purine ribonucleoside salvage(GO:0006166)
0.3 0.9 GO:0000092 mitotic anaphase B(GO:0000092) plasmid partitioning(GO:0030541)
0.3 3.1 GO:0052803 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.3 4.5 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.3 1.2 GO:0034473 U1 snRNA 3'-end processing(GO:0034473)
0.3 0.9 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.3 1.5 GO:0043102 L-methionine biosynthetic process from methylthioadenosine(GO:0019509) amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
0.3 37.9 GO:0002181 cytoplasmic translation(GO:0002181)
0.3 1.7 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.3 0.9 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.3 1.7 GO:0006491 N-glycan processing(GO:0006491)
0.3 0.8 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.3 1.4 GO:0051351 positive regulation of ligase activity(GO:0051351)
0.3 1.1 GO:0045141 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.3 2.9 GO:0007120 axial cellular bud site selection(GO:0007120)
0.3 0.3 GO:0032365 intracellular lipid transport(GO:0032365)
0.3 2.9 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.3 1.0 GO:0050667 transsulfuration(GO:0019346) homocysteine metabolic process(GO:0050667)
0.2 0.7 GO:0042992 negative regulation of transcription factor import into nucleus(GO:0042992)
0.2 1.0 GO:0098740 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.2 2.7 GO:0015988 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.2 1.4 GO:0000303 response to superoxide(GO:0000303) response to oxygen radical(GO:0000305) removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) detoxification(GO:0098754) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.2 1.2 GO:0071406 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
0.2 1.2 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.2 0.5 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.2 5.3 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.2 1.4 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.2 0.9 GO:0015867 ATP transport(GO:0015867)
0.2 1.1 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.2 1.8 GO:0000376 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.2 3.6 GO:0030488 tRNA methylation(GO:0030488)
0.2 1.1 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.2 0.9 GO:0036170 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
0.2 0.9 GO:0046677 response to antibiotic(GO:0046677)
0.2 2.7 GO:0006415 translational termination(GO:0006415)
0.2 0.2 GO:0019357 nicotinate nucleotide biosynthetic process(GO:0019357) nicotinate nucleotide salvage(GO:0019358) pyridine nucleotide salvage(GO:0019365) nicotinate nucleotide metabolic process(GO:0046497)
0.2 5.0 GO:0006696 ergosterol biosynthetic process(GO:0006696) phytosteroid biosynthetic process(GO:0016129) cellular alcohol biosynthetic process(GO:0044108) cellular lipid biosynthetic process(GO:0097384)
0.2 0.9 GO:0009636 response to toxic substance(GO:0009636)
0.2 0.2 GO:0007535 donor selection(GO:0007535)
0.2 1.7 GO:0006882 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.2 0.8 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.2 5.6 GO:0045047 protein targeting to ER(GO:0045047)
0.2 0.8 GO:0060188 regulation of protein desumoylation(GO:0060188)
0.2 2.3 GO:0009435 NAD biosynthetic process(GO:0009435)
0.2 0.9 GO:0009263 deoxyribonucleotide metabolic process(GO:0009262) deoxyribonucleotide biosynthetic process(GO:0009263)
0.2 0.6 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.2 0.5 GO:0032006 regulation of TOR signaling(GO:0032006)
0.2 1.3 GO:0006901 vesicle coating(GO:0006901)
0.2 0.5 GO:0043171 peptide catabolic process(GO:0043171)
0.2 1.9 GO:0006743 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) ketone biosynthetic process(GO:0042181) quinone metabolic process(GO:1901661) quinone biosynthetic process(GO:1901663)
0.2 0.7 GO:0009099 valine biosynthetic process(GO:0009099)
0.2 3.1 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.2 1.5 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.2 4.6 GO:0045454 cell redox homeostasis(GO:0045454)
0.2 1.0 GO:0072337 modified amino acid transport(GO:0072337)
0.2 0.5 GO:0006567 threonine catabolic process(GO:0006567)
0.2 0.6 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.2 1.0 GO:0006797 polyphosphate metabolic process(GO:0006797)
0.2 0.3 GO:0030834 regulation of actin filament depolymerization(GO:0030834) negative regulation of actin filament depolymerization(GO:0030835) barbed-end actin filament capping(GO:0051016) actin filament capping(GO:0051693)
0.2 3.9 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.2 0.5 GO:1904667 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) regulation of ubiquitin protein ligase activity(GO:1904666) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.2 0.5 GO:0006850 mitochondrial pyruvate transport(GO:0006850)
0.1 2.2 GO:0002097 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.1 0.4 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.1 0.6 GO:0006177 GMP biosynthetic process(GO:0006177)
0.1 0.7 GO:0006458 'de novo' protein folding(GO:0006458)
0.1 0.4 GO:0006531 aspartate metabolic process(GO:0006531)
0.1 0.7 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228)
0.1 0.9 GO:0032508 DNA duplex unwinding(GO:0032508)
0.1 0.7 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.1 0.7 GO:0045116 protein neddylation(GO:0045116)
0.1 3.8 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.1 2.0 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.1 1.6 GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.1 1.4 GO:0030011 maintenance of cell polarity(GO:0030011)
0.1 0.1 GO:0010695 regulation of spindle pole body separation(GO:0010695)
0.1 0.5 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 0.2 GO:0034402 recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex(GO:0034402)
0.1 1.8 GO:0006885 regulation of pH(GO:0006885)
0.1 1.1 GO:0001510 RNA methylation(GO:0001510)
0.1 1.7 GO:0018208 protein peptidyl-prolyl isomerization(GO:0000413) peptidyl-proline modification(GO:0018208)
0.1 0.5 GO:0072668 obsolete tubulin complex biogenesis(GO:0072668)
0.1 0.2 GO:0006784 heme a biosynthetic process(GO:0006784) heme a metabolic process(GO:0046160)
0.1 1.4 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 1.1 GO:0015918 sterol transport(GO:0015918)
0.1 0.1 GO:0048194 Golgi vesicle budding(GO:0048194)
0.1 1.5 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 0.2 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571) mitotic G1/S transition checkpoint(GO:0044819)
0.1 2.3 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.1 0.1 GO:0001015 snoRNA transcription from an RNA polymerase II promoter(GO:0001015)
0.1 0.6 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.1 0.8 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 2.4 GO:0006184 obsolete GTP catabolic process(GO:0006184)
0.1 5.6 GO:0006839 mitochondrial transport(GO:0006839)
0.1 1.7 GO:0006337 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.1 0.4 GO:0046655 folic acid metabolic process(GO:0046655) folic acid biosynthetic process(GO:0046656)
0.1 0.1 GO:0035306 positive regulation of dephosphorylation(GO:0035306) positive regulation of protein dephosphorylation(GO:0035307)
0.1 0.8 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.1 0.4 GO:0006074 (1->3)-beta-D-glucan metabolic process(GO:0006074)
0.1 0.8 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.1 0.6 GO:0042991 transcription factor import into nucleus(GO:0042991)
0.1 0.7 GO:0015833 peptide transport(GO:0015833)
0.1 1.5 GO:0006606 protein import into nucleus(GO:0006606) nuclear import(GO:0051170) single-organism nuclear import(GO:1902593)
0.1 0.6 GO:0051666 actin cortical patch localization(GO:0051666)
0.1 0.5 GO:0061572 actin filament bundle assembly(GO:0051017) actin filament bundle organization(GO:0061572)
0.1 0.5 GO:0010921 regulation of phosphatase activity(GO:0010921) regulation of protein dephosphorylation(GO:0035304)
0.1 0.2 GO:0001109 promoter clearance during DNA-templated transcription(GO:0001109) promoter clearance from RNA polymerase II promoter(GO:0001111)
0.1 0.9 GO:0007009 plasma membrane organization(GO:0007009)
0.1 0.8 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.1 0.2 GO:0006624 vacuolar protein processing(GO:0006624)
0.1 0.2 GO:0046939 nucleotide phosphorylation(GO:0046939)
0.1 0.5 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 1.0 GO:0008219 apoptotic process(GO:0006915) cell death(GO:0008219) programmed cell death(GO:0012501)
0.1 0.4 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 0.3 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.1 0.3 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.1 0.2 GO:1900101 regulation of endoplasmic reticulum unfolded protein response(GO:1900101)
0.1 1.8 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.1 1.8 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.1 0.7 GO:0006037 cell wall chitin metabolic process(GO:0006037)
0.1 0.4 GO:0043457 regulation of cellular respiration(GO:0043457)
0.1 0.3 GO:0071051 polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.1 0.3 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.9 GO:0015749 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.1 0.5 GO:0009306 protein secretion(GO:0009306)
0.1 0.6 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.1 5.4 GO:0006364 rRNA processing(GO:0006364)
0.1 0.5 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 0.4 GO:0006771 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.1 0.6 GO:0000917 barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529)
0.1 0.4 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.1 0.3 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.1 0.6 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.1 1.8 GO:0000910 cytokinesis(GO:0000910)
0.1 0.3 GO:0006621 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.1 0.1 GO:0034067 protein localization to Golgi apparatus(GO:0034067)
0.1 0.1 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.1 0.3 GO:0018344 protein geranylgeranylation(GO:0018344)
0.1 0.1 GO:0000957 mitochondrial RNA catabolic process(GO:0000957)
0.1 0.3 GO:0046219 tryptophan biosynthetic process(GO:0000162) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
0.0 0.8 GO:0009451 RNA modification(GO:0009451)
0.0 0.2 GO:0060277 obsolete negative regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0060277)
0.0 0.3 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.0 0.0 GO:0043038 amino acid activation(GO:0043038) tRNA aminoacylation(GO:0043039)
0.0 0.6 GO:0042797 tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0 0.1 GO:0007329 positive regulation of transcription from RNA polymerase II promoter by pheromones(GO:0007329) positive regulation of transcription by pheromones(GO:0009371)
0.0 0.2 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0 0.0 GO:1902807 negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 0.2 GO:0010458 exit from mitosis(GO:0010458)
0.0 0.1 GO:0000743 nuclear migration involved in conjugation with cellular fusion(GO:0000743)
0.0 0.2 GO:0009187 cyclic nucleotide metabolic process(GO:0009187)
0.0 0.2 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396) pteridine-containing compound biosynthetic process(GO:0042559)
0.0 0.1 GO:0070827 chromatin maintenance(GO:0070827)
0.0 0.2 GO:0000730 meiotic DNA recombinase assembly(GO:0000707) DNA recombinase assembly(GO:0000730)
0.0 0.1 GO:0071428 rRNA-containing ribonucleoprotein complex export from nucleus(GO:0071428)
0.0 0.1 GO:0033239 negative regulation of cellular amine metabolic process(GO:0033239)
0.0 0.2 GO:0006734 NADH metabolic process(GO:0006734)
0.0 0.3 GO:0055070 cellular copper ion homeostasis(GO:0006878) copper ion homeostasis(GO:0055070)
0.0 1.1 GO:0006413 translational initiation(GO:0006413)
0.0 0.4 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.2 GO:0030846 termination of RNA polymerase II transcription, poly(A)-coupled(GO:0030846)
0.0 0.1 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.9 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 0.1 GO:0090114 COPII-coated vesicle budding(GO:0090114)
0.0 0.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.1 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.0 0.5 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.0 2.1 GO:0032543 mitochondrial translation(GO:0032543)
0.0 1.0 GO:0006457 protein folding(GO:0006457)
0.0 0.5 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.2 GO:0006273 lagging strand elongation(GO:0006273)
0.0 0.2 GO:0001300 chronological cell aging(GO:0001300)
0.0 0.9 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.0 0.1 GO:0045722 positive regulation of glucose metabolic process(GO:0010907) positive regulation of gluconeogenesis(GO:0045722)
0.0 0.4 GO:0046467 GPI anchor biosynthetic process(GO:0006506) membrane lipid biosynthetic process(GO:0046467)
0.0 0.1 GO:0006998 nuclear envelope organization(GO:0006998)
0.0 0.1 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0 0.1 GO:0006814 sodium ion transport(GO:0006814)
0.0 0.1 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.0 GO:0008216 spermidine metabolic process(GO:0008216)
0.0 0.1 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.0 0.0 GO:2000221 negative regulation of cell growth(GO:0030308) negative regulation of pseudohyphal growth(GO:2000221)
0.0 0.2 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.0 0.0 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.1 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 0.4 GO:0006865 amino acid transport(GO:0006865)
0.0 0.0 GO:0042182 ketone catabolic process(GO:0042182)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 7.3 GO:0032299 ribonuclease H2 complex(GO:0032299)
1.1 3.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
1.0 3.9 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.7 8.7 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.7 2.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.7 2.1 GO:0030428 cell septum(GO:0030428)
0.6 3.2 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.4 1.3 GO:0043529 GET complex(GO:0043529)
0.4 1.7 GO:0097255 R2TP complex(GO:0097255)
0.4 1.7 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.4 2.6 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.4 1.3 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
0.4 1.6 GO:0031207 endoplasmic reticulum Sec complex(GO:0031205) Sec62/Sec63 complex(GO:0031207)
0.4 1.9 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.4 2.7 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.4 1.1 GO:0000137 Golgi cis cisterna(GO:0000137)
0.4 29.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.3 2.4 GO:0000346 transcription export complex(GO:0000346)
0.3 2.0 GO:0032126 eisosome(GO:0032126)
0.3 1.0 GO:0045298 polar microtubule(GO:0005827) tubulin complex(GO:0045298)
0.3 1.3 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.3 19.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.3 0.9 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.3 2.5 GO:0042597 periplasmic space(GO:0042597)
0.3 2.1 GO:0033180 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.3 0.9 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.3 0.5 GO:0000131 incipient cellular bud site(GO:0000131)
0.3 3.6 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.2 0.7 GO:0097344 Rix1 complex(GO:0097344)
0.2 4.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 9.0 GO:0005811 lipid particle(GO:0005811)
0.2 0.7 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.2 1.2 GO:0034518 RNA cap binding complex(GO:0034518)
0.2 4.1 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.2 0.9 GO:0033179 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.2 0.9 GO:0044611 nuclear pore inner ring(GO:0044611)
0.2 0.9 GO:0045254 mitochondrial pyruvate dehydrogenase complex(GO:0005967) pyruvate dehydrogenase complex(GO:0045254)
0.2 0.6 GO:0005787 signal peptidase complex(GO:0005787)
0.2 3.2 GO:0005940 septin ring(GO:0005940)
0.2 1.5 GO:0031933 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.2 0.6 GO:0005662 DNA replication factor A complex(GO:0005662)
0.2 0.6 GO:0031415 NatA complex(GO:0031415)
0.2 1.2 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.2 4.3 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.2 0.9 GO:0030478 actin cap(GO:0030478)
0.2 1.1 GO:0005871 kinesin complex(GO:0005871)
0.2 1.0 GO:0042555 MCM complex(GO:0042555)
0.2 4.1 GO:0005887 integral component of plasma membrane(GO:0005887)
0.2 0.5 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.2 2.9 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.2 0.5 GO:0030689 Noc complex(GO:0030689)
0.2 1.0 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.2 0.5 GO:0033186 CAF-1 complex(GO:0033186)
0.1 2.0 GO:0022626 cytosolic ribosome(GO:0022626)
0.1 0.3 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.1 1.1 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 0.8 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.1 0.7 GO:0035339 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.1 0.4 GO:0005796 Golgi lumen(GO:0005796)
0.1 0.4 GO:0070545 PeBoW complex(GO:0070545)
0.1 0.5 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.1 1.0 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 1.1 GO:0000243 commitment complex(GO:0000243)
0.1 21.5 GO:0005933 cellular bud(GO:0005933)
0.1 0.4 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 4.2 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 0.8 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.1 0.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 0.9 GO:0005688 U6 snRNP(GO:0005688)
0.1 1.3 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.1 5.8 GO:0030684 preribosome(GO:0030684)
0.1 1.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 1.7 GO:0016586 RSC complex(GO:0016586)
0.1 3.7 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 0.8 GO:0045277 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.1 0.6 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 0.9 GO:0034399 nuclear periphery(GO:0034399)
0.1 1.7 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.1 2.6 GO:0044445 cytosolic part(GO:0044445)
0.1 2.6 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 0.5 GO:0072686 mitotic spindle(GO:0072686)
0.1 0.3 GO:0034448 EGO complex(GO:0034448)
0.1 0.2 GO:0032301 MutSalpha complex(GO:0032301)
0.1 7.9 GO:0005730 nucleolus(GO:0005730)
0.1 0.3 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.1 0.6 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.1 0.2 GO:0043291 RAVE complex(GO:0043291)
0.1 13.3 GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network(GO:0042175)
0.1 0.4 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 0.7 GO:0005685 U1 snRNP(GO:0005685)
0.1 0.4 GO:0016272 prefoldin complex(GO:0016272)
0.1 0.4 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 0.2 GO:0030907 MBF transcription complex(GO:0030907)
0.1 0.8 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 0.2 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.0 0.2 GO:0000817 COMA complex(GO:0000817)
0.0 0.1 GO:0031417 NatC complex(GO:0031417)
0.0 3.3 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 0.2 GO:0034044 exomer complex(GO:0034044)
0.0 0.2 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 1.9 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.5 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.1 GO:0000792 heterochromatin(GO:0000792)
0.0 5.6 GO:0005829 cytosol(GO:0005829)
0.0 0.2 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.1 GO:0033597 mitotic checkpoint complex(GO:0033597)
0.0 0.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.1 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.2 GO:0030662 coated vesicle membrane(GO:0030662)
0.0 0.9 GO:0043332 mating projection tip(GO:0043332)
0.0 0.2 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 0.4 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.4 GO:0005844 polysome(GO:0005844)
0.0 0.3 GO:0046695 SLIK (SAGA-like) complex(GO:0046695)
0.0 0.2 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.2 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.3 GO:0070210 Rpd3L-Expanded complex(GO:0070210)
0.0 1.0 GO:0005635 nuclear envelope(GO:0005635)
0.0 0.2 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 1.6 GO:0005759 mitochondrial matrix(GO:0005759)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 13.6 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
2.3 6.8 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
1.8 7.3 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
1.4 8.7 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
1.4 5.4 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
1.3 7.8 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
1.2 1.2 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
1.2 3.7 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
1.2 7.3 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
1.1 3.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
1.0 4.1 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.9 3.6 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
0.8 3.3 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.8 3.2 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.8 2.3 GO:0016274 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.7 2.2 GO:0019003 GDP binding(GO:0019003)
0.7 2.1 GO:0015658 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.7 2.7 GO:0016841 ammonia-lyase activity(GO:0016841)
0.7 2.0 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.6 1.9 GO:0070568 guanylyltransferase activity(GO:0070568)
0.6 5.6 GO:0004497 monooxygenase activity(GO:0004497)
0.6 1.8 GO:0072341 modified amino acid binding(GO:0072341)
0.6 1.8 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.6 2.4 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.5 1.6 GO:0009922 fatty acid elongase activity(GO:0009922)
0.5 1.5 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825)
0.5 1.9 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.5 1.8 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.4 1.8 GO:1904680 peptide transmembrane transporter activity(GO:1904680)
0.4 1.3 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.4 1.3 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.4 1.3 GO:0000339 RNA cap binding(GO:0000339)
0.4 2.1 GO:0004707 MAP kinase activity(GO:0004707)
0.4 0.8 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.4 0.4 GO:0015248 sterol transporter activity(GO:0015248)
0.4 1.9 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.4 1.9 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.4 2.3 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.4 1.5 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.4 1.1 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.4 1.5 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.4 1.8 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.3 1.7 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.3 1.7 GO:0043139 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.3 4.8 GO:0070566 adenylyltransferase activity(GO:0070566)
0.3 11.1 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.3 3.7 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.3 1.0 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.3 1.3 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.3 4.6 GO:0015036 disulfide oxidoreductase activity(GO:0015036)
0.3 1.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.3 1.5 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.3 0.9 GO:0031370 eukaryotic initiation factor 4G binding(GO:0031370)
0.3 0.9 GO:0004738 pyruvate dehydrogenase activity(GO:0004738)
0.3 2.7 GO:0005496 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.3 2.4 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.3 2.5 GO:0005216 ion channel activity(GO:0005216)
0.2 5.6 GO:0019901 protein kinase binding(GO:0019901)
0.2 1.0 GO:0008172 S-methyltransferase activity(GO:0008172)
0.2 4.1 GO:0001056 RNA polymerase III activity(GO:0001056)
0.2 49.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 0.9 GO:0009378 four-way junction helicase activity(GO:0009378)
0.2 0.9 GO:0019206 nucleoside kinase activity(GO:0019206)
0.2 0.7 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
0.2 0.9 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.2 1.7 GO:0031490 chromatin DNA binding(GO:0031490)
0.2 1.9 GO:0015079 potassium ion transmembrane transporter activity(GO:0015079)
0.2 0.8 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.2 1.0 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.2 1.0 GO:0008526 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.2 1.0 GO:0070403 NAD+ binding(GO:0070403)
0.2 1.0 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.2 0.6 GO:0016504 peptidase activator activity(GO:0016504)
0.2 2.8 GO:0001671 ATPase activator activity(GO:0001671)
0.2 1.5 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.2 0.2 GO:0004805 trehalose-phosphatase activity(GO:0004805)
0.2 4.0 GO:0042162 telomeric DNA binding(GO:0042162)
0.2 3.2 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.2 3.0 GO:0000049 tRNA binding(GO:0000049)
0.2 0.6 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.2 1.1 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)
0.2 1.0 GO:0030145 manganese ion binding(GO:0030145)
0.2 0.9 GO:0034318 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.2 0.9 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.2 0.5 GO:0070569 uridylyltransferase activity(GO:0070569)
0.2 1.0 GO:0003993 acid phosphatase activity(GO:0003993)
0.2 0.5 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.2 0.9 GO:0042124 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.2 0.5 GO:0051219 phosphoprotein binding(GO:0051219)
0.2 0.6 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.2 0.5 GO:0016882 cyclo-ligase activity(GO:0016882)
0.2 0.5 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.1 1.1 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 2.0 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 0.3 GO:0016840 carbon-nitrogen lyase activity(GO:0016840)
0.1 0.5 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 0.4 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 0.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 0.4 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 0.5 GO:0001129 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132)
0.1 0.4 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 4.4 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.1 7.8 GO:0003924 GTPase activity(GO:0003924)
0.1 0.7 GO:0016408 C-acyltransferase activity(GO:0016408)
0.1 1.4 GO:0005199 structural constituent of cell wall(GO:0005199)
0.1 0.3 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.4 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.1 0.4 GO:0008198 ferrous iron binding(GO:0008198)
0.1 0.5 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.1 0.7 GO:0001139 transcription factor activity, core RNA polymerase II recruiting(GO:0001139)
0.1 5.5 GO:0008565 protein transporter activity(GO:0008565)
0.1 0.3 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.1 0.5 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 1.5 GO:0051087 chaperone binding(GO:0051087)
0.1 0.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.7 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 2.9 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.1 0.9 GO:0003777 microtubule motor activity(GO:0003777)
0.1 0.7 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 1.4 GO:0005048 signal sequence binding(GO:0005048)
0.1 0.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 0.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 0.7 GO:0043022 ribosome binding(GO:0043022)
0.1 0.3 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 0.3 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.1 0.3 GO:0019211 phosphatase activator activity(GO:0019211)
0.1 2.8 GO:0030674 protein binding, bridging(GO:0030674)
0.1 0.3 GO:0004622 lysophospholipase activity(GO:0004622)
0.1 0.8 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.1 0.3 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 0.6 GO:0051920 thioredoxin peroxidase activity(GO:0008379) peroxiredoxin activity(GO:0051920)
0.1 2.2 GO:0051536 iron-sulfur cluster binding(GO:0051536) metal cluster binding(GO:0051540)
0.1 0.5 GO:0000295 adenine nucleotide transmembrane transporter activity(GO:0000295)
0.1 0.9 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 0.2 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.1 0.2 GO:0004017 adenylate kinase activity(GO:0004017)
0.1 0.7 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 0.3 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.1 2.2 GO:0016853 isomerase activity(GO:0016853)
0.1 0.8 GO:0015179 L-amino acid transmembrane transporter activity(GO:0015179)
0.1 2.6 GO:0042393 histone binding(GO:0042393)
0.1 0.3 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.1 0.2 GO:0016433 rRNA (adenine) methyltransferase activity(GO:0016433)
0.1 0.8 GO:0043495 protein anchor(GO:0043495)
0.1 0.7 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024) histone methyltransferase activity(GO:0042054)
0.1 1.6 GO:0016875 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 0.5 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.1 0.1 GO:0015211 purine nucleoside transmembrane transporter activity(GO:0015211)
0.1 0.1 GO:0003785 actin monomer binding(GO:0003785)
0.1 0.3 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.1 0.4 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.1 0.7 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.3 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.1 0.2 GO:0001055 RNA polymerase II activity(GO:0001055)
0.1 0.4 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 0.2 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.1 0.3 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 1.1 GO:0003743 translation initiation factor activity(GO:0003743) translation factor activity, RNA binding(GO:0008135)
0.1 0.2 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.1 0.2 GO:0001168 transcription factor activity, RNA polymerase I upstream control element sequence-specific binding(GO:0001168)
0.0 2.1 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.4 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.7 GO:0051287 NAD binding(GO:0051287)
0.0 0.1 GO:0035591 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.0 0.2 GO:0004180 carboxypeptidase activity(GO:0004180)
0.0 0.3 GO:0010181 FMN binding(GO:0010181)
0.0 0.2 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.0 0.6 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.0 0.2 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.1 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.3 GO:0051015 actin filament binding(GO:0051015)
0.0 0.1 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.6 GO:0003779 actin binding(GO:0003779)
0.0 0.5 GO:0005319 lipid transporter activity(GO:0005319)
0.0 0.1 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.1 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.0 0.1 GO:0008252 nucleotidase activity(GO:0008252)
0.0 0.4 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0 0.1 GO:0003840 gamma-glutamyltransferase activity(GO:0003840)
0.0 0.3 GO:0019239 deaminase activity(GO:0019239)
0.0 0.7 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.1 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.1 GO:0004771 sterol esterase activity(GO:0004771)
0.0 0.4 GO:0019207 kinase regulator activity(GO:0019207)
0.0 0.2 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.2 GO:0019904 protein domain specific binding(GO:0019904)
0.0 0.3 GO:0019843 rRNA binding(GO:0019843)
0.0 0.3 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.0 0.5 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.2 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 0.1 GO:0001179 RNA polymerase I transcription factor binding(GO:0001179)
0.0 3.9 GO:0003723 RNA binding(GO:0003723)
0.0 0.8 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.1 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.6 PID SHP2 PATHWAY SHP2 signaling
0.8 1.7 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.7 2.1 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.6 1.2 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.5 2.1 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.5 0.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 0.3 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.1 0.2 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 0.3 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 0.2 PID NOTCH PATHWAY Notch signaling pathway
0.1 0.4 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.1 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.0 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.0 PID MYC PATHWAY C-MYC pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.7 REACTOME SIGNALLING TO ERKS Genes involved in Signalling to ERKs
1.0 7.8 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.9 2.8 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.9 3.4 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.7 2.0 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.5 2.8 REACTOME SIGNALING BY GPCR Genes involved in Signaling by GPCR
0.4 0.9 REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION Genes involved in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
0.3 5.5 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.3 0.9 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.3 0.8 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.2 0.7 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.2 1.3 REACTOME LAGGING STRAND SYNTHESIS Genes involved in Lagging Strand Synthesis
0.2 0.2 REACTOME SIGNALING BY THE B CELL RECEPTOR BCR Genes involved in Signaling by the B Cell Receptor (BCR)
0.2 1.2 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.2 1.0 REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM Genes involved in Cytokine Signaling in Immune system
0.2 0.3 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.1 1.0 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.1 0.5 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.1 0.8 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 0.4 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.1 0.6 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.1 0.5 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 0.1 REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.1 0.1 REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION Genes involved in Platelet activation, signaling and aggregation
0.1 0.1 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.3 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.3 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.1 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.2 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.1 REACTOME APOPTOSIS Genes involved in Apoptosis