Results for CRZ1

Z-value: 1.21

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Transcription factors associated with CRZ1

Gene Symbol Gene ID Gene Info
S000004972 Transcription factor that activates genes involved in stress response

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of CRZ1 motif

Sorted Z-values of CRZ1 motif

Promoter Log-likelihood Transcript Gene Gene Info
YIL162W 6.33 Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YER150W 5.55 GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YKL217W 4.91 Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YAL062W 4.64 NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YKR097W 4.58 Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YMR107W 4.57 Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YMR081C 4.49 Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YCR005C 4.49 Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YKL044W 4.25 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL171C 4.13 Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YBR056W-A 4.12 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR056C-B
YOL154W 3.87 Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
YOR100C 3.85 Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YPR036W-A 3.85 Protein of unknown function; transcription is regulated by Pdr1p
YJR095W 3.82 Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YJL045W 3.66 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YLL055W 3.57 High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
YPL250C 3.55 Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YIL057C 3.50 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YKL043W 3.50 Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate
YOL082W 3.41 Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; recognizes cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) and delivers them to the preautophagosomal structure for packaging into Cvt vesicles
YPL017C 3.35 Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family, required for accurate meiotic chromosome segregation; null mutant displays increased levels of spontaneous Rad52 foci
YAL039C 3.31 Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YOR343C 3.30 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YJL199C 3.26 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies
YNL194C 3.16 Integral membrane protein localized to eisosomes; sporulation and plasma membrane sphingolipid content are altered in mutants; has homologs SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YFR053C 3.10 Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YGR191W 3.04 High-affinity histidine permease, also involved in the transport of manganese ions
YDR343C 3.03 High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YOR382W 2.98 Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YGL062W 2.97 Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis
YEL008W 2.93 Hypothetical protein predicted to be involved in metabolism
YER158C 2.91 Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p
YBR067C 2.88 Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
YLR327C 2.80 Protein of unknown function that associates with ribosomes
YGR032W 2.80 Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
YDR342C 2.79 High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YOR220W 2.74 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS
YPL271W 2.64 Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YGR190C 2.62 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
YCR010C 2.62 Acetate transporter required for normal sporulation; phosphorylated in mitochondria
YFL030W 2.60 Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YKL148C 2.57 Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YLR122C 2.55 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YCR021C 2.52 Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YGR065C 2.50 High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
YGR142W 2.49 v-SNARE binding protein that facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase
YJL103C 2.47 Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis
YEL060C 2.44 Vacuolar proteinase B (yscB), a serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation
YJL089W 2.42 C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus
YHR145C 2.39 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YAL054C 2.38 Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YNL305C 2.38 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL305C is not an essential gene
YBR077C 2.38 Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
YGR243W 2.37 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR379C-A 2.32 Hypothetical protein identified by homology. See FEBS Letters [2000] 487:31-36.
YDL210W 2.32 Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YDL234C 2.31 GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking
YEL009C 2.27 Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YGR268C 2.25 Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
YGR087C 2.23 Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YBL064C 2.23 Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress; phosphorylated
YOR378W 2.20 Putative protein of unknown function; belongs to the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
YLL056C 2.18 Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene
YOL084W 2.16 Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YOR348C 2.16 Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YPL111W 2.15 Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance
YPL223C 2.14 Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YHL021C 2.14 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YKL086W 2.13 Sulfiredoxin, contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxins Tsa1p and Ahp1p that are formed upon exposure to oxidants; conserved in higher eukaryotes
YKL163W 2.13 O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YLR438W 2.13 L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive
YMR017W 2.13 Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YDR536W 2.12 Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YJL217W 2.11 Cytoplasmic protein of unknown function; expression induced by calcium shortage and via the copper sensing transciption factor Mac1p during conditons of copper deficiency; mRNA is cell cycle regulated, peaking in G1 phase
YLR123C 2.11 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YPR196W 2.08 Putative maltose activator
YJR078W 1.99 Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p
YGR236C 1.98 Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR032C 1.96 Protein with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR476C 1.95 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene
YBR072W 1.90 Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YCL038C 1.89 Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation
YPL054W 1.89 Zinc-finger protein of unknown function
YLR377C 1.87 Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YBR284W 1.87 Putative protein of unknown function; YBR284W is not an essential gene; null mutant exhibits decreased resistance to rapamycin and wortmannin
YGR144W 1.85 Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YPL134C 1.83 Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation
YAR050W 1.83 Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YJR120W 1.81 Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
YJR115W 1.79 Putative protein of unknown function
YCR068W 1.78 Lipase, required for intravacuolar lysis of autophagosomes; located in the endoplasmic reticulum membrane and targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway
YJL213W 1.76 Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p
YOR235W 1.75 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci
YAL034C 1.74 Non-essential protein of unknown function
YAR053W 1.74 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJR061W 1.73 Putative protein of unknown function; non-essential gene with similarity to Mnn4, a putative membrane protein involved in glycosylation; transcription repressed by Rm101p
YLR437C-A 1.73 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CAR2/YLR438W
YOR178C 1.73 Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YDR525W-A 1.72 Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YBR117C 1.71 Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YGL045W 1.71 Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF
YGR067C 1.70 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YOL052C-A 1.70 Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses
YIR027C 1.65 Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression
YPR154W 1.63 Protein that induces appearance of [PIN+] prion when overproduced
YHR092C 1.63 High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YBR293W 1.63 Permease of basic amino acids in the vacuolar membrane
YFL052W 1.63 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YPR192W 1.62 Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance
YOR072W-A 1.62 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR072W; originally identified by fungal homology and RT-PCR
YAR035W 1.62 Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
YOR134W 1.62 Rho GTPase activating protein (RhoGAP), stimulates the intrinsic GTPase activity of Rho1p, which plays a role in actin cytoskeleton organization and control of cell wall synthesis; structurally and functionally related to Sac7p
YPR002W 1.59 Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate
YMR170C 1.57 Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p
YGL191W 1.57 Subunit VIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP
YBR182C 1.57 Putative transcription factor involved in regulating the response to osmotic stress; member of the MADS-box family of transcription factors
YJR077C 1.56 Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated
YBR296C 1.56 Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
YPR013C 1.54 Putative zinc finger protein; YPR013C is not an essential gene
YKL038W 1.54 Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor
YGR088W 1.52 Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YMR311C 1.52 Regulatory subunit of protein phosphatase 1 (Glc7p), involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2
YML058W 1.52 Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase
YGR254W 1.52 Enolase I, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose
YNL134C 1.51 Putative protein of unknown function with similarity to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced by the DNA-damaging agent MMS
YFR047C 1.50 Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
YMR191W 1.49 Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YHR212C 1.49 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR376W 1.49 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.
YMR040W 1.47 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
YMR165C 1.46 Mg2+-dependent phosphatidate (PA) phosphatase, catalyzes the dephosphorylation of PA to yield diacylglycerol and Pi, responsible for de novo lipid synthesis; homologous to mammalian lipin 1
YNL144C 1.46 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YAR060C 1.46 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR059C 1.45 Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins, central component of the cellular stress response; expression is heat inducible
YHL040C 1.43 Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores
YER088C 1.41 Protein of unknown function, involved in telomeric gene silencing and filamentation
YBR201C-A 1.41 Putative protein of unknown function
YFR015C 1.41 Glycogen synthase with similarity to Gsy2p, the more highly expressed yeast homolog; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase
YJR045C 1.41 Mitochondrial matrix ATPase, subunit of the presequence translocase-associated protein import motor (PAM) and of SceI endonuclease; involved in protein folding and translocation into the matrix; phosphorylated; member of HSP70 family
YLL053C 1.40 Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YCL042W 1.40 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YOL060C 1.40 Protein required for normal mitochondrial morphology, has similarity to hemolysins
YGL184C 1.40 Cystathionine beta-lyase, converts cystathionine into homocysteine
YML070W 1.39 Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
YML100W 1.38 Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose, homologous to Tps3p and may share function
YPR149W 1.37 Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs)
YDL012C 1.37 Plasma membrane protein of unknown function; YDL012C is not an essential gene
YPR145C-A 1.36 Putative protein of unknown function
YOR173W 1.36 Non-essential, stress induced regulatory protein containing a HIT (histidine triad) motif; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway, similar to Dcs1p.
YER091C-A 1.35 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR250C 1.35 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YCL040W 1.35 Glucokinase, catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources
YOL129W 1.35 Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria
YJR106W 1.33 Non-essential protein of unknown function
YLR214W 1.33 Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels
YFR022W 1.33 Protein that binds to Rsp5p, which is a hect-type ubiquitin ligase, via its 2 PY motifs; has similarity to Rod1p; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant
YDR249C 1.32 Putative protein of unknown function
YDR453C 1.32 Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants
YMR297W 1.32 Vacuolar carboxypeptidase Y (proteinase C), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family
YJR046W 1.31 DNA replication licensing factor, required for pre-replication complex assembly
YLR149C 1.31 Putative protein of unknown function; YLR149C is not an essential gene
YNL115C 1.30 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
YMR244W 1.30 Putative protein of unknown function
YNL322C 1.29 Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
YKL146W 1.28 Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YHL036W 1.27 Low affinity methionine permease, similar to Mup1p
YOR381W 1.25 Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
YCL025C 1.25 Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)
YDR251W 1.24 Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype
YHR212W-A 1.24 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YKR011C 1.24 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YPR030W 1.24 Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate
YNL142W 1.24 Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YLL052C 1.23 Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YGR041W 1.23 Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole
YNL125C 1.22 Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
YGL248W 1.21 Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation
YLR094C 1.21 Protein of unknown function
YOR072W 1.21 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YLL060C 1.21 Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p
YGR043C 1.21 Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity
YBR297W 1.20 MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C
YOR071C 1.19 High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
YER065C 1.19 Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YNL160W 1.18 Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p
YKL147C 1.18 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3
YHR087W 1.18 Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity
YGL162W 1.18 Transcription factor of the Zn[II]2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression
YNL093W 1.17 GTPase, similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis
YOL085W-A 1.17 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YOL085C
YFL019C 1.17 Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene
YIL099W 1.16 Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
YBL015W 1.16 Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YIL166C 1.15 Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene
YGR149W 1.15 Putative protein of unknown function; predicted to be an integal membrane protein
YFL051C 1.15 Putative protein of unknown function; YFL051C is not an essential gene
YLR046C 1.14 Putative membrane protein, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
YDR036C 1.14 3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis
YPL018W 1.14 Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly

Network of associatons between targets according to the STRING database.

First level regulatory network of CRZ1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 7.5 GO:0006848 pyruvate transport(GO:0006848)
1.5 6.0 GO:0046323 glucose import(GO:0046323)
1.2 3.7 GO:0018063 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
1.2 3.6 GO:0015740 C4-dicarboxylate transport(GO:0015740)
1.2 4.6 GO:0015804 neutral amino acid transport(GO:0015804)
1.1 3.3 GO:0006545 glycine biosynthetic process(GO:0006545)
1.0 4.2 GO:0006527 arginine catabolic process(GO:0006527)
1.0 2.9 GO:0061414 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
0.9 5.7 GO:0045117 azole transport(GO:0045117)
0.9 2.8 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
0.9 2.7 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.9 2.7 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.9 3.6 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.9 4.4 GO:0044746 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.8 2.5 GO:0019543 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
0.8 6.6 GO:0015891 siderophore transport(GO:0015891)
0.8 0.8 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.8 6.0 GO:0005985 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.7 6.6 GO:0046487 glyoxylate metabolic process(GO:0046487)
0.7 2.9 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
0.7 0.7 GO:0015755 fructose transport(GO:0015755)
0.7 2.0 GO:0036257 multivesicular body organization(GO:0036257)
0.6 1.9 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.6 2.5 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.6 3.1 GO:0034354 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.6 1.8 GO:0006740 NADPH regeneration(GO:0006740)
0.6 3.6 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.6 1.2 GO:0005980 glycogen catabolic process(GO:0005980)
0.6 7.9 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.6 1.7 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.6 2.8 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.5 4.9 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.5 1.1 GO:0008216 spermidine metabolic process(GO:0008216)
0.5 1.1 GO:0090295 nitrogen catabolite repression of transcription(GO:0090295)
0.5 2.1 GO:0015847 putrescine transport(GO:0015847)
0.5 4.7 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.5 2.1 GO:0006598 polyamine catabolic process(GO:0006598)
0.5 1.0 GO:0052547 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
0.5 3.0 GO:0006085 acetyl-CoA biosynthetic process(GO:0006085)
0.5 1.4 GO:0043335 protein unfolding(GO:0043335)
0.5 2.3 GO:0019405 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.5 3.7 GO:0042816 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.5 5.0 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.4 0.4 GO:0042542 response to hydrogen peroxide(GO:0042542)
0.4 1.3 GO:0006538 glutamate catabolic process(GO:0006538)
0.4 0.8 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.4 3.3 GO:0072348 sulfur compound transport(GO:0072348)
0.4 1.6 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) negative regulation of actin nucleation(GO:0051126)
0.4 10.6 GO:0006094 gluconeogenesis(GO:0006094)
0.4 4.1 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.4 1.2 GO:0015976 carbon utilization(GO:0015976)
0.4 1.2 GO:0042843 D-xylose catabolic process(GO:0042843)
0.4 1.1 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.4 1.9 GO:0000023 maltose metabolic process(GO:0000023)
0.4 1.5 GO:0015886 heme transport(GO:0015886)
0.4 1.5 GO:0015793 glycerol transport(GO:0015793)
0.4 0.7 GO:0042732 D-xylose metabolic process(GO:0042732)
0.4 1.1 GO:0006784 heme a biosynthetic process(GO:0006784) heme a metabolic process(GO:0046160)
0.4 1.1 GO:0090155 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.4 1.1 GO:0009107 lipoate metabolic process(GO:0009106) lipoate biosynthetic process(GO:0009107)
0.3 1.4 GO:2000911 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.3 1.0 GO:0043200 response to amino acid(GO:0043200)
0.3 1.0 GO:0034762 regulation of transmembrane transport(GO:0034762)
0.3 1.0 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.3 1.3 GO:0034389 lipid particle organization(GO:0034389)
0.3 1.6 GO:0046058 cAMP metabolic process(GO:0046058)
0.3 9.2 GO:0045454 cell redox homeostasis(GO:0045454)
0.3 7.3 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.3 5.9 GO:0001101 response to acid chemical(GO:0001101)
0.3 1.8 GO:0006537 glutamate biosynthetic process(GO:0006537)
0.3 1.8 GO:0000256 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256)
0.3 2.9 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.3 0.8 GO:0071281 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.3 0.6 GO:0010674 negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010674)
0.3 1.1 GO:0032102 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.3 2.2 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.3 1.1 GO:0046688 response to copper ion(GO:0046688)
0.3 3.0 GO:0019740 nitrogen utilization(GO:0019740)
0.3 5.3 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.3 3.9 GO:0006865 amino acid transport(GO:0006865)
0.3 0.8 GO:0043171 peptide catabolic process(GO:0043171)
0.3 1.3 GO:0051099 positive regulation of binding(GO:0051099)
0.2 2.5 GO:0006119 oxidative phosphorylation(GO:0006119)
0.2 0.7 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.2 0.2 GO:0000304 response to singlet oxygen(GO:0000304)
0.2 2.1 GO:0006829 zinc II ion transport(GO:0006829)
0.2 0.9 GO:0046185 aldehyde catabolic process(GO:0046185)
0.2 0.5 GO:0006754 ATP biosynthetic process(GO:0006754)
0.2 0.7 GO:0010994 free ubiquitin chain polymerization(GO:0010994)
0.2 0.4 GO:0006032 aminoglycan catabolic process(GO:0006026) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.2 1.3 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.2 0.4 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.2 0.6 GO:0046352 disaccharide catabolic process(GO:0046352)
0.2 0.6 GO:0045836 positive regulation of meiotic nuclear division(GO:0045836)
0.2 1.2 GO:0006768 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.2 3.0 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.2 2.1 GO:0015893 drug transport(GO:0015893)
0.2 2.1 GO:0042724 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.2 1.3 GO:0015677 copper ion import(GO:0015677)
0.2 3.8 GO:0098656 anion transmembrane transport(GO:0098656)
0.2 0.2 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.2 1.3 GO:0055071 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.2 0.2 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.2 1.4 GO:0009306 protein secretion(GO:0009306)
0.2 0.7 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.2 0.5 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.2 0.2 GO:0072350 tricarboxylic acid metabolic process(GO:0072350)
0.2 3.4 GO:0031503 protein complex localization(GO:0031503)
0.2 0.5 GO:0045596 negative regulation of cell differentiation(GO:0045596) negative regulation of developmental process(GO:0051093)
0.2 0.8 GO:0008053 mitochondrial fusion(GO:0008053)
0.2 1.4 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.2 1.5 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 1.6 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889) regulation of vacuole organization(GO:0044088)
0.1 0.4 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.1 0.9 GO:0006077 (1->6)-beta-D-glucan metabolic process(GO:0006077)
0.1 0.9 GO:0015851 nucleobase transport(GO:0015851)
0.1 0.6 GO:0000709 meiotic joint molecule formation(GO:0000709)
0.1 0.7 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.1 1.3 GO:0045332 phospholipid translocation(GO:0045332)
0.1 0.3 GO:0019748 secondary metabolic process(GO:0019748)
0.1 0.1 GO:0045981 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.1 0.3 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.1 0.3 GO:0015691 cadmium ion transport(GO:0015691)
0.1 0.5 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.1 0.3 GO:0006531 aspartate metabolic process(GO:0006531)
0.1 0.1 GO:0051273 beta-glucan metabolic process(GO:0051273)
0.1 0.8 GO:0006465 signal peptide processing(GO:0006465)
0.1 0.3 GO:0000272 polysaccharide catabolic process(GO:0000272)
0.1 0.4 GO:0046466 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.1 5.2 GO:0009060 aerobic respiration(GO:0009060)
0.1 0.4 GO:0010446 response to alkaline pH(GO:0010446) cellular response to pH(GO:0071467) cellular response to alkaline pH(GO:0071469)
0.1 3.4 GO:0043248 proteasome assembly(GO:0043248)
0.1 2.1 GO:0000209 protein polyubiquitination(GO:0000209)
0.1 4.7 GO:0070726 cell wall assembly(GO:0070726)
0.1 0.4 GO:0006089 lactate metabolic process(GO:0006089)
0.1 0.2 GO:0090054 regulation of chromatin silencing at silent mating-type cassette(GO:0090054)
0.1 0.2 GO:0051606 detection of chemical stimulus(GO:0009593) detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) detection of stimulus(GO:0051606)
0.1 0.5 GO:2000105 positive regulation of DNA-dependent DNA replication(GO:2000105)
0.1 1.9 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.1 0.4 GO:0016577 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.1 0.4 GO:0031138 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.1 0.6 GO:0032447 protein urmylation(GO:0032447)
0.1 0.5 GO:0045996 negative regulation of transcription by pheromones(GO:0045996) negative regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046020)
0.1 0.6 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 0.9 GO:0031167 rRNA methylation(GO:0031167)
0.1 0.1 GO:0000963 mitochondrial RNA processing(GO:0000963)
0.1 0.5 GO:0019722 calcium-mediated signaling(GO:0019722)
0.1 0.1 GO:0015688 iron chelate transport(GO:0015688)
0.1 0.5 GO:0046461 triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)
0.1 0.1 GO:0051222 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
0.1 0.2 GO:0034090 maintenance of meiotic sister chromatid cohesion(GO:0034090)
0.1 0.7 GO:0006826 iron ion transport(GO:0006826)
0.1 0.1 GO:0034503 protein localization to nucleolar rDNA repeats(GO:0034503)
0.1 0.5 GO:0009208 CTP biosynthetic process(GO:0006241) pyrimidine ribonucleoside triphosphate metabolic process(GO:0009208) pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209) CTP metabolic process(GO:0046036)
0.1 0.3 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.1 0.7 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 1.0 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.1 0.3 GO:0009062 fatty acid catabolic process(GO:0009062)
0.1 1.1 GO:0046834 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.1 0.3 GO:0090220 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.1 1.4 GO:1902532 negative regulation of intracellular signal transduction(GO:1902532)
0.1 0.7 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.1 0.2 GO:0045471 response to ethanol(GO:0045471)
0.1 1.1 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.1 1.4 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.1 0.3 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.1 1.5 GO:1902534 membrane invagination(GO:0010324) lysosomal microautophagy(GO:0016237) single-organism membrane invagination(GO:1902534)
0.1 0.5 GO:0043461 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615) proton-transporting ATP synthase complex assembly(GO:0043461)
0.1 0.7 GO:0022900 electron transport chain(GO:0022900)
0.1 1.3 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.1 0.4 GO:0030308 negative regulation of cell growth(GO:0030308) negative regulation of pseudohyphal growth(GO:2000221)
0.1 0.4 GO:0006084 acetyl-CoA metabolic process(GO:0006084)
0.1 0.7 GO:0034085 establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087)
0.1 0.2 GO:0033499 galactose catabolic process(GO:0019388) galactose catabolic process via UDP-galactose(GO:0033499)
0.1 0.7 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.1 1.2 GO:0008219 apoptotic process(GO:0006915) cell death(GO:0008219) programmed cell death(GO:0012501)
0.1 0.1 GO:0090630 activation of GTPase activity(GO:0090630)
0.1 0.3 GO:0006816 calcium ion transport(GO:0006816)
0.1 0.2 GO:0006000 fructose metabolic process(GO:0006000)
0.1 0.3 GO:0061393 positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress(GO:0061393)
0.1 0.9 GO:0006895 Golgi to endosome transport(GO:0006895)
0.1 0.3 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.1 0.2 GO:0015693 magnesium ion transport(GO:0015693)
0.1 1.1 GO:0008645 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.1 0.5 GO:0007323 peptide pheromone maturation(GO:0007323)
0.1 0.6 GO:0009395 phospholipid catabolic process(GO:0009395)
0.1 0.2 GO:0046686 response to cadmium ion(GO:0046686)
0.1 0.5 GO:0070987 error-free translesion synthesis(GO:0070987)
0.1 0.3 GO:0048209 regulation of COPII vesicle coating(GO:0003400) regulation of vesicle targeting, to, from or within Golgi(GO:0048209) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.1 0.3 GO:0061408 positive regulation of transcription from RNA polymerase II promoter in response to heat stress(GO:0061408)
0.1 0.2 GO:0006047 UDP-N-acetylglucosamine metabolic process(GO:0006047) UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.1 0.1 GO:0015865 purine nucleotide transport(GO:0015865) purine ribonucleotide transport(GO:0015868) adenine nucleotide transport(GO:0051503)
0.1 2.7 GO:0035825 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.1 0.2 GO:0035459 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.1 0.2 GO:0051260 protein homooligomerization(GO:0051260)
0.0 0.1 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.0 0.3 GO:0042026 protein refolding(GO:0042026)
0.0 0.2 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.0 0.1 GO:0050685 regulation of RNA splicing(GO:0043484) regulation of mRNA splicing, via spliceosome(GO:0048024) positive regulation of mRNA processing(GO:0050685)
0.0 0.3 GO:0000338 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.0 0.1 GO:0042407 cristae formation(GO:0042407)
0.0 0.4 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0 0.1 GO:0016239 positive regulation of autophagy(GO:0010508) positive regulation of macroautophagy(GO:0016239)
0.0 0.2 GO:0030100 regulation of endocytosis(GO:0030100)
0.0 0.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.1 GO:0090114 COPII-coated vesicle budding(GO:0090114)
0.0 0.2 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.2 GO:0016562 receptor recycling(GO:0001881) protein import into peroxisome matrix, receptor recycling(GO:0016562) receptor metabolic process(GO:0043112)
0.0 0.1 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.2 GO:0006591 ornithine metabolic process(GO:0006591)
0.0 0.8 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.0 0.3 GO:0030242 pexophagy(GO:0030242)
0.0 0.2 GO:0015940 pantothenate metabolic process(GO:0015939) pantothenate biosynthetic process(GO:0015940)
0.0 0.3 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.2 GO:0009164 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.0 0.1 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.0 0.5 GO:0042493 response to drug(GO:0042493)
0.0 0.4 GO:0010525 regulation of transposition, RNA-mediated(GO:0010525)
0.0 0.1 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.0 1.3 GO:0006839 mitochondrial transport(GO:0006839)
0.0 1.0 GO:0006661 phosphatidylinositol biosynthetic process(GO:0006661)
0.0 0.1 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.2 GO:0046931 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.0 0.1 GO:0000390 spliceosomal complex disassembly(GO:0000390)
0.0 0.0 GO:0018202 peptidyl-histidine modification(GO:0018202)
0.0 0.3 GO:0001558 regulation of cell growth(GO:0001558)
0.0 0.1 GO:0000196 MAPK cascade involved in cell wall organization or biogenesis(GO:0000196)
0.0 0.1 GO:0009312 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.0 0.3 GO:0000742 karyogamy involved in conjugation with cellular fusion(GO:0000742)
0.0 0.1 GO:0070933 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0 0.1 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491)
0.0 0.1 GO:0001109 promoter clearance during DNA-templated transcription(GO:0001109) promoter clearance from RNA polymerase II promoter(GO:0001111)
0.0 0.1 GO:0007006 mitochondrial membrane organization(GO:0007006)
0.0 0.0 GO:0071243 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061395) cellular response to arsenic-containing substance(GO:0071243)
0.0 0.0 GO:0006687 glycosphingolipid metabolic process(GO:0006687)
0.0 0.1 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.0 GO:0018410 C-terminal protein amino acid modification(GO:0018410) post-translational protein modification(GO:0043687)
0.0 0.1 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.0 0.2 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.0 0.0 GO:0001196 regulation of mating-type specific transcription from RNA polymerase II promoter(GO:0001196) negative regulation of mating-type specific transcription from RNA polymerase II promoter(GO:0001198) negative regulation of mating-type specific transcription, DNA-templated(GO:0045894)
0.0 0.0 GO:0097198 positive regulation of histone H3-K36 methylation(GO:0000416) histone H3-K36 trimethylation(GO:0097198) regulation of histone H3-K36 trimethylation(GO:2001253) positive regulation of histone H3-K36 trimethylation(GO:2001255)
0.0 0.1 GO:0070124 mitochondrial translational initiation(GO:0070124)
0.0 0.1 GO:0009092 homoserine metabolic process(GO:0009092)
0.0 0.1 GO:0000080 mitotic G1 phase(GO:0000080) G1 phase(GO:0051318)
0.0 0.1 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.0 0.1 GO:0030847 termination of RNA polymerase II transcription, exosome-dependent(GO:0030847)
0.0 0.0 GO:0017004 cytochrome complex assembly(GO:0017004)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 4.0 GO:0005756 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
1.0 1.0 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
1.0 2.9 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.8 3.1 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.7 4.1 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.7 7.2 GO:0005775 vacuolar lumen(GO:0005775)
0.6 2.8 GO:0045273 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.5 1.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.5 1.4 GO:0030061 mitochondrial crista(GO:0030061)
0.4 1.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.4 3.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.4 3.7 GO:0045263 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.4 2.7 GO:0034657 GID complex(GO:0034657)
0.3 1.8 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.3 1.4 GO:0072380 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.3 5.6 GO:0070469 respiratory chain(GO:0070469)
0.3 20.0 GO:0005576 extracellular region(GO:0005576)
0.3 1.0 GO:0000817 COMA complex(GO:0000817)
0.3 0.8 GO:0005787 signal peptidase complex(GO:0005787)
0.3 0.8 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.2 1.2 GO:0034448 EGO complex(GO:0034448)
0.2 2.1 GO:0031225 anchored component of membrane(GO:0031225)
0.2 4.8 GO:0042764 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.2 0.7 GO:0005796 Golgi lumen(GO:0005796)
0.2 1.2 GO:0033101 cellular bud membrane(GO:0033101)
0.2 0.6 GO:0046930 pore complex(GO:0046930)
0.2 4.1 GO:0009277 fungal-type cell wall(GO:0009277)
0.2 8.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.2 2.9 GO:0070822 Sin3-type complex(GO:0070822)
0.2 1.6 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2 0.5 GO:0070274 RES complex(GO:0070274)
0.1 0.3 GO:0001400 mating projection base(GO:0001400)
0.1 0.4 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259)
0.1 20.7 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 0.4 GO:0033255 SAS acetyltransferase complex(GO:0033255)
0.1 0.4 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)
0.1 2.2 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.1 6.7 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 1.0 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.1 0.5 GO:0038201 TORC2 complex(GO:0031932) TOR complex(GO:0038201)
0.1 0.8 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.1 0.7 GO:0032432 actin filament bundle(GO:0032432)
0.1 0.3 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 0.6 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 0.3 GO:0034099 luminal surveillance complex(GO:0034099)
0.1 2.0 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 0.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 13.3 GO:0000323 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.1 0.3 GO:0033309 SBF transcription complex(GO:0033309)
0.1 0.4 GO:0034967 Set3 complex(GO:0034967)
0.1 2.0 GO:0005740 mitochondrial envelope(GO:0005740)
0.1 0.3 GO:0045254 mitochondrial pyruvate dehydrogenase complex(GO:0005967) pyruvate dehydrogenase complex(GO:0045254)
0.1 0.7 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 1.2 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 0.4 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 0.2 GO:0035649 Nrd1 complex(GO:0035649)
0.1 0.2 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.1 0.3 GO:0032865 ERMES complex(GO:0032865) ER-mitochondrion membrane contact site(GO:0044233)
0.1 0.3 GO:0030669 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128) endocytic vesicle(GO:0030139) endocytic vesicle membrane(GO:0030666) clathrin-coated endocytic vesicle membrane(GO:0030669) clathrin-coated endocytic vesicle(GO:0045334)
0.1 3.8 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 16.6 GO:0005886 plasma membrane(GO:0005886)
0.0 0.3 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.1 GO:0000837 Doa10p ubiquitin ligase complex(GO:0000837)
0.0 0.4 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0 0.2 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.2 GO:0005869 dynactin complex(GO:0005869)
0.0 0.1 GO:0051286 cell tip(GO:0051286)
0.0 0.3 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.1 GO:0032389 MutLalpha complex(GO:0032389)
0.0 0.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.3 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.3 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.0 0.1 GO:0005825 half bridge of spindle pole body(GO:0005825)
0.0 0.3 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.6 GO:0000152 nuclear ubiquitin ligase complex(GO:0000152)
0.0 0.1 GO:0033551 monopolin complex(GO:0033551)
0.0 0.1 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.0 1.2 GO:0030479 actin cortical patch(GO:0030479) endocytic patch(GO:0061645)
0.0 1.4 GO:0000502 proteasome complex(GO:0000502)
0.0 0.1 GO:0032126 eisosome(GO:0032126)
0.0 0.1 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.0 0.6 GO:0016592 mediator complex(GO:0016592)
0.0 0.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.1 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0 0.1 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.0 0.2 GO:0000812 Swr1 complex(GO:0000812)
0.0 10.4 GO:0005739 mitochondrion(GO:0005739)
0.0 0.2 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.1 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) nucleoplasmic THO complex(GO:0000446)
0.0 0.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.0 GO:0097196 Shu complex(GO:0097196)
0.0 0.1 GO:0000500 RNA polymerase I upstream activating factor complex(GO:0000500)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.6 GO:0004575 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
1.9 5.8 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
1.9 9.5 GO:0015295 solute:proton symporter activity(GO:0015295)
1.4 4.2 GO:1901474 azole transmembrane transporter activity(GO:1901474)
1.3 5.3 GO:0004396 hexokinase activity(GO:0004396)
1.2 3.6 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
1.0 4.0 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.9 2.8 GO:0016289 CoA hydrolase activity(GO:0016289)
0.9 2.8 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
0.9 3.6 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.9 2.7 GO:0016208 AMP binding(GO:0016208)
0.9 3.6 GO:0005537 mannose binding(GO:0005537)
0.9 4.4 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.9 2.6 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.8 2.4 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.7 2.2 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.7 2.9 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
0.7 2.8 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
0.7 2.7 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.6 7.1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.6 2.5 GO:0042927 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.6 0.6 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.6 3.0 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.6 2.8 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.5 2.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.5 1.6 GO:0005302 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.5 2.1 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.5 5.2 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.5 3.6 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.5 2.5 GO:0008198 ferrous iron binding(GO:0008198)
0.5 4.5 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.5 1.4 GO:0004864 protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
0.5 1.9 GO:0051183 vitamin transporter activity(GO:0051183)
0.5 1.4 GO:0004458 D-lactate dehydrogenase (cytochrome) activity(GO:0004458)
0.4 5.2 GO:0022838 substrate-specific channel activity(GO:0022838)
0.4 1.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.4 2.1 GO:0004806 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.4 2.1 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.4 1.2 GO:0004866 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
0.4 1.6 GO:0015085 calcium ion transmembrane transporter activity(GO:0015085)
0.4 2.7 GO:0004364 glutathione transferase activity(GO:0004364)
0.4 0.8 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.4 1.5 GO:0004180 carboxypeptidase activity(GO:0004180)
0.4 2.6 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.4 1.1 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.3 5.6 GO:0016831 carboxy-lyase activity(GO:0016831)
0.3 2.8 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.3 1.0 GO:0050136 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.3 2.8 GO:0010181 FMN binding(GO:0010181)
0.3 1.0 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.3 2.7 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.3 0.7 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.3 6.2 GO:0008483 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.3 2.2 GO:0004601 peroxidase activity(GO:0004601) oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)
0.3 2.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.3 2.5 GO:0000149 SNARE binding(GO:0000149)
0.3 2.5 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.3 2.1 GO:0016209 antioxidant activity(GO:0016209)
0.3 0.9 GO:0048029 monosaccharide binding(GO:0048029)
0.3 1.8 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.3 2.7 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.3 1.1 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.3 0.8 GO:0004805 trehalose-phosphatase activity(GO:0004805)
0.3 2.5 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions(GO:0016722) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.3 1.4 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.3 0.6 GO:0019903 phosphatase binding(GO:0019902) protein phosphatase binding(GO:0019903)
0.3 1.1 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.3 2.7 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.3 1.6 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.3 1.3 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.3 3.9 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.3 2.0 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 0.7 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.2 3.1 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.2 2.3 GO:0015297 antiporter activity(GO:0015297)
0.2 2.7 GO:0005199 structural constituent of cell wall(GO:0005199)
0.2 1.1 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.2 1.1 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.2 1.1 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.2 0.6 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.2 0.4 GO:0032452 histone demethylase activity(GO:0032452) histone demethylase activity (H3-K36 specific)(GO:0051864)
0.2 0.6 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.2 0.6 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.2 2.5 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors(GO:0016645)
0.2 1.4 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.2 0.9 GO:0008171 O-methyltransferase activity(GO:0008171)
0.2 1.6 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 0.9 GO:0052742 phosphatidylinositol kinase activity(GO:0052742)
0.2 1.2 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.2 0.5 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.2 0.5 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.2 0.3 GO:0003840 gamma-glutamyltransferase activity(GO:0003840)
0.2 0.6 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.2 0.6 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
0.2 1.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.2 2.6 GO:0050661 NADP binding(GO:0050661)
0.2 3.6 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 1.2 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035) disulfide oxidoreductase activity(GO:0015036)
0.1 0.4 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.1 1.3 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 1.0 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.1 0.4 GO:0000150 recombinase activity(GO:0000150)
0.1 0.8 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.1 0.4 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.1 0.5 GO:0017171 serine hydrolase activity(GO:0017171)
0.1 1.2 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 0.3 GO:0015203 polyamine transmembrane transporter activity(GO:0015203)
0.1 0.5 GO:0004622 lysophospholipase activity(GO:0004622)
0.1 3.4 GO:0008237 metallopeptidase activity(GO:0008237)
0.1 1.0 GO:0017136 NAD-dependent histone deacetylase activity(GO:0017136) NAD-dependent protein deacetylase activity(GO:0034979)
0.1 0.5 GO:0016651 oxidoreductase activity, acting on NAD(P)H(GO:0016651)
0.1 0.3 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.1 0.6 GO:0016830 carbon-carbon lyase activity(GO:0016830)
0.1 0.2 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 0.2 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
0.1 0.3 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
0.1 0.5 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.1 0.5 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.1 0.6 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.1 0.9 GO:0005507 copper ion binding(GO:0005507)
0.1 1.4 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.1 0.3 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.1 0.7 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.1 0.3 GO:0017022 myosin binding(GO:0017022)
0.1 0.5 GO:0042124 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.1 0.1 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.1 0.4 GO:0004559 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.1 0.1 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.1 0.4 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.1 0.1 GO:0042947 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.1 1.3 GO:0005509 calcium ion binding(GO:0005509)
0.1 2.8 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 0.1 GO:0016405 CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
0.1 0.3 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.1 0.1 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.1 0.6 GO:0008374 O-acyltransferase activity(GO:0008374)
0.1 0.3 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.1 0.2 GO:0019211 phosphatase activator activity(GO:0019211)
0.1 0.9 GO:0036442 hydrogen-exporting ATPase activity(GO:0036442)
0.1 0.2 GO:0097617 RNA strand annealing activity(GO:0033592) annealing activity(GO:0097617)
0.1 0.3 GO:0000400 four-way junction DNA binding(GO:0000400)
0.1 0.3 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 0.1 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.1 0.3 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.1 0.2 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.0 0.4 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 0.1 GO:0019776 Atg8 ligase activity(GO:0019776)
0.0 0.1 GO:0008972 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.0 0.9 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 0.3 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.3 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.4 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.9 GO:0061733 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.0 3.0 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 0.0 GO:0004075 biotin carboxylase activity(GO:0004075)
0.0 0.5 GO:0005342 organic acid transmembrane transporter activity(GO:0005342)
0.0 0.1 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.1 GO:0042973 glucan endo-1,3-beta-D-glucosidase activity(GO:0042973)
0.0 0.1 GO:0019238 cyclohydrolase activity(GO:0019238)
0.0 0.1 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.1 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.0 GO:0048038 quinone binding(GO:0048038)
0.0 0.5 GO:0051087 chaperone binding(GO:0051087)
0.0 0.4 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.3 GO:0051287 NAD binding(GO:0051287)
0.0 0.1 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.1 GO:0019104 DNA N-glycosylase activity(GO:0019104)
0.0 0.2 GO:0015578 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.0 0.1 GO:0001083 transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083)
0.0 0.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.1 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 0.1 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.1 GO:0001168 transcription factor activity, RNA polymerase I upstream control element sequence-specific binding(GO:0001168)
0.0 0.1 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.1 GO:0043495 protein anchor(GO:0043495)
0.0 0.4 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.1 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.0 0.1 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 0.0 GO:0015216 purine nucleotide transmembrane transporter activity(GO:0015216)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.5 PID IL4 2PATHWAY IL4-mediated signaling events
1.6 4.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
1.0 3.1 PID AR PATHWAY Coregulation of Androgen receptor activity
0.6 1.9 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.6 3.4 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.5 1.0 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.2 0.6 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.2 0.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 0.1 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 0.5 PID PLK1 PATHWAY PLK1 signaling events
0.1 0.1 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.1 0.3 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 0.1 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.1 0.2 PID P73PATHWAY p73 transcription factor network
0.0 0.1 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 65.2 PID TELOMERASE PATHWAY Regulation of Telomerase

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 7.6 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.5 1.4 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.3 1.1 REACTOME BIOLOGICAL OXIDATIONS Genes involved in Biological oxidations
0.1 0.4 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 0.4 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 0.8 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 0.1 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 0.4 REACTOME HEMOSTASIS Genes involved in Hemostasis
0.0 0.1 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.0 64.8 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.1 REACTOME AXON GUIDANCE Genes involved in Axon guidance