Results for CRZ1
Z-value: 1.21
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Transcription factors associated with CRZ1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
CRZ1
|
S000004972 | Transcription factor that activates genes involved in stress response |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YIL162W Show fit | 6.33 |
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively |
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| YER150W Show fit | 5.55 |
GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p |
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| YKL217W Show fit | 4.91 |
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose |
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| YAL062W Show fit | 4.64 |
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources |
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| YKR097W Show fit | 4.58 |
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol |
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| YMR107W Show fit | 4.57 |
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources |
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| YMR081C Show fit | 4.49 |
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant |
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| YCR005C Show fit | 4.49 |
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors |
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| YKL044W Show fit | 4.25 |
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
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| YPL171C Show fit | 4.13 |
Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism |
Network of associatons between targets according to the STRING database.
First level regulatory network of CRZ1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 10.6 | GO:0006094 | gluconeogenesis(GO:0006094) |
| 0.3 | 9.2 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 0.6 | 7.9 | GO:0015986 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 1.9 | 7.5 | GO:0006848 | pyruvate transport(GO:0006848) |
| 0.3 | 7.3 | GO:0000422 | mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726) |
| 0.8 | 6.6 | GO:0015891 | siderophore transport(GO:0015891) |
| 0.7 | 6.6 | GO:0046487 | glyoxylate metabolic process(GO:0046487) |
| 1.5 | 6.0 | GO:0046323 | glucose import(GO:0046323) |
| 0.8 | 6.0 | GO:0005985 | sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987) |
| 0.3 | 5.9 | GO:0001101 | response to acid chemical(GO:0001101) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 20.7 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.3 | 20.0 | GO:0005576 | extracellular region(GO:0005576) |
| 0.1 | 16.6 | GO:0005886 | plasma membrane(GO:0005886) |
| 0.1 | 13.3 | GO:0000323 | storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324) |
| 0.0 | 10.4 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.2 | 8.3 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.7 | 7.2 | GO:0005775 | vacuolar lumen(GO:0005775) |
| 0.1 | 6.7 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.3 | 5.6 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.2 | 4.8 | GO:0042764 | prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 9.5 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 0.6 | 7.1 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 2.2 | 6.6 | GO:0004575 | beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575) |
| 0.3 | 6.2 | GO:0008483 | transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769) |
| 1.9 | 5.8 | GO:0036440 | citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440) |
| 0.3 | 5.6 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 1.3 | 5.3 | GO:0004396 | hexokinase activity(GO:0004396) |
| 0.5 | 5.2 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 0.4 | 5.2 | GO:0022838 | substrate-specific channel activity(GO:0022838) |
| 0.5 | 4.5 | GO:0016668 | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 65.2 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 2.2 | 6.5 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 1.6 | 4.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.6 | 3.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 1.0 | 3.1 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.6 | 1.9 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.5 | 1.0 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.2 | 0.6 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.2 | 0.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 0.5 | PID PLK1 PATHWAY | PLK1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 64.8 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.8 | 7.6 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.5 | 1.4 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.3 | 1.1 | REACTOME BIOLOGICAL OXIDATIONS | Genes involved in Biological oxidations |
| 0.1 | 0.8 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.1 | 0.4 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.1 | 0.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 0.4 | REACTOME HEMOSTASIS | Genes involved in Hemostasis |
| 0.1 | 0.1 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.0 | 0.1 | REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS | Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways |