Results for CIN5
Z-value: 2.66
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Transcription factors associated with CIN5
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
CIN5
|
S000005554 | Basic leucine zipper (bZIP) transcription factor of the yAP-1 family |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YKL163W Show fit | 28.13 |
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway |
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| YLR327C Show fit | 20.50 |
Protein of unknown function that associates with ribosomes |
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| YMR107W Show fit | 19.23 |
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources |
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| YNL117W Show fit | 18.43 |
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium |
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| YAL062W Show fit | 17.96 |
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources |
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| YLR122C Show fit | 17.61 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C |
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| YER065C Show fit | 16.92 |
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose |
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| YKR097W Show fit | 16.63 |
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol |
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| YLR123C Show fit | 14.92 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif |
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| YER150W Show fit | 14.17 |
GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p |
Network of associatons between targets according to the STRING database.
First level regulatory network of CIN5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.5 | 40.9 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 1.1 | 32.1 | GO:0006094 | gluconeogenesis(GO:0006094) |
| 1.6 | 31.4 | GO:0005978 | glycogen biosynthetic process(GO:0005978) |
| 0.2 | 25.5 | GO:0045229 | external encapsulating structure organization(GO:0045229) cell wall organization(GO:0071555) |
| 1.3 | 22.9 | GO:0001101 | response to acid chemical(GO:0001101) |
| 1.6 | 21.9 | GO:0009228 | thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724) |
| 0.5 | 19.3 | GO:0009060 | aerobic respiration(GO:0009060) |
| 0.3 | 16.9 | GO:0007031 | peroxisome organization(GO:0007031) |
| 2.6 | 15.9 | GO:0000128 | flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501) |
| 1.7 | 15.2 | GO:0070086 | ubiquitin-dependent endocytosis(GO:0070086) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 49.0 | GO:0005739 | mitochondrion(GO:0005739) |
| 1.0 | 46.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.3 | 36.6 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 2.8 | 33.0 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 21.0 | GO:0005886 | plasma membrane(GO:0005886) |
| 0.7 | 17.0 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.4 | 15.5 | GO:0005576 | extracellular region(GO:0005576) |
| 1.1 | 14.8 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.3 | 14.6 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 1.8 | 14.4 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 40.0 | GO:0001228 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 5.2 | 25.8 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 2.1 | 22.6 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 2.6 | 20.5 | GO:0031072 | heat shock protein binding(GO:0031072) |
| 4.8 | 19.1 | GO:0016639 | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639) |
| 1.5 | 18.1 | GO:0005199 | structural constituent of cell wall(GO:0005199) |
| 0.9 | 16.4 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 2.2 | 15.7 | GO:0016833 | oxo-acid-lyase activity(GO:0016833) |
| 3.8 | 15.0 | GO:0005537 | mannose binding(GO:0005537) |
| 2.6 | 13.1 | GO:0008198 | ferrous iron binding(GO:0008198) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 411.2 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 6.8 | 20.3 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 4.7 | 14.2 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.8 | 2.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.4 | 1.3 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.3 | 1.3 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 0.6 | 1.2 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.2 | 0.9 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 0.5 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 0.1 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 400.8 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 2.4 | 21.3 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 1.4 | 4.1 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 1.2 | 3.6 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.4 | 3.6 | REACTOME DNA REPAIR | Genes involved in DNA Repair |
| 0.5 | 3.4 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.8 | 3.2 | REACTOME DOUBLE STRAND BREAK REPAIR | Genes involved in Double-Strand Break Repair |
| 0.5 | 1.9 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.1 | 1.4 | REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS | Genes involved in Metabolism of lipids and lipoproteins |
| 0.4 | 0.8 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |