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Results for CIN5

Z-value: 2.66

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Transcription factors associated with CIN5

Gene Symbol Gene ID Gene Info
CIN5
S000005554 Basic leucine zipper (bZIP) transcription factor of the yAP-1 family

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
CIN5YOR028C0.376.4e-02Click!

Activity profile of CIN5 motif

Sorted Z-values of CIN5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YKL163W 28.13
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YLR327C 20.50
TMA10
Protein of unknown function that associates with ribosomes
YMR107W 19.23
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YNL117W 18.43
MLS1
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YAL062W 17.96
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YLR122C 17.61 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YER065C 16.92
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YKR097W 16.63
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YLR123C 14.92 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YER150W 14.17
SPI1
GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YKL109W 14.06
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YMR034C 13.32 Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene
YOR178C 12.48
GAC1
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YLR311C 11.75 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR124W 11.59 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL220W 11.46 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL221C/FSP2
YDL244W 11.26
THI13
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YBR201C-A 11.20 Putative protein of unknown function
YAR053W 11.19 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YML131W 10.73 Putative protein of unknown function with similarity to oxidoreductases; HOG1 and SKO1-dependent mRNA expression is induced after osmotic shock; GFP-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS
YGR144W 10.63
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YKL026C 10.39
GPX1
Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YIL057C 10.34 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YPL018W 10.30
CTF19
Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly
YOR100C 10.28
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YJL221C 10.11
FSP2
Protein of unknown function, expression is induced during nitrogen limitation
YLR142W 10.06
PUT1
Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
YBR076C-A 10.01 Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene ECM8; identified by fungal homology and RT-PCR
YLR125W 9.76 Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene
YCL025C 9.42
AGP1
Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)
YBR182C 9.42
SMP1
Putative transcription factor involved in regulating the response to osmotic stress; member of the MADS-box family of transcription factors
YDR119W-A 9.28 Putative protein of unknown function
YKL044W 9.20 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL219W 9.07
HXT9
Putative hexose transporter that is nearly identical to Hxt11p, has similarity to major facilitator superfamily (MFS) transporters, expression of HXT9 is regulated by transcription factors Pdr1p and Pdr3p
YMR118C 9.00 Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene
YJR154W 8.96 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YAR035W 8.87
YAT1
Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
YKL217W 8.85
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YAR060C 8.69 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR178W 8.57
SDH4
Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YCR068W 8.51
ATG15
Lipase, required for intravacuolar lysis of autophagosomes; located in the endoplasmic reticulum membrane and targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway
YPR013C 8.50 Putative zinc finger protein; YPR013C is not an essential gene
YFL030W 8.41
AGX1
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YMR090W 8.26 Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR090W is not an essential gene
YKL067W 8.20
YNK1
Nucleoside diphosphate kinase, catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate
YJL217W 8.16 Cytoplasmic protein of unknown function; expression induced by calcium shortage and via the copper sensing transciption factor Mac1p during conditons of copper deficiency; mRNA is cell cycle regulated, peaking in G1 phase
YIR039C 8.07
YPS6
Putative GPI-anchored aspartic protease
YJL116C 8.03
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YJR152W 8.02
DAL5
Allantoin permease; ureidosuccinate permease; expression is constitutive but sensitive to nitrogen catabolite repression
YFR022W 8.00
ROG3
Protein that binds to Rsp5p, which is a hect-type ubiquitin ligase, via its 2 PY motifs; has similarity to Rod1p; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant
YLR356W 7.97 Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YDR540C 7.72
IRC4
Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YOL052C-A 7.69
DDR2
Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses
YCR091W 7.64
KIN82
Putative serine/threonine protein kinase, most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily
YER038W-A 7.59
FMP49
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria
YHR092C 7.50
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YOL157C 7.46 Putative protein of unknown function
YGL192W 7.39
IME4
Probable mRNA N6-adenosine methyltransferase that is required for IME1 transcript accumulation and for sporulation; expression is induced in starved MATa/MAT alpha diploid cells
YGL193C 7.23 Haploid-specific gene repressed by a1-alpha2, turned off in sir3 null strains, absence enhances the sensitivity of rad52-327 cells to campothecin almost 100-fold
YNL200C 7.14 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR289C 7.05
MAL11
Inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; broad substrate specificity that includes maltotriose
YCR021C 7.04
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YLR346C 6.95 Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene
YBR296C 6.91
PHO89
Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
YGL255W 6.90
ZRT1
High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YPL258C 6.90
THI21
Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p
YIL045W 6.78
PIG2
Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase
YJR146W 6.68 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2
YLL053C 6.66 Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YPR015C 6.62 Putative protein of unknown function
YLR149C 6.58 Putative protein of unknown function; YLR149C is not an essential gene
YGL191W 6.55
COX13
Subunit VIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP
YOL151W 6.43
GRE2
3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YKR102W 6.37
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YGR290W 6.36 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter)
YEL008W 6.28 Hypothetical protein predicted to be involved in metabolism
YEL009C-A 6.27 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL169C 6.11
UGX2
Protein of unknown function, transcript accumulates in response to any combination of stress conditions
YKL065W-A 6.04 Putative protein of unknown function
YBL015W 6.01
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YKL043W 5.99
PHD1
Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate
YMR035W 5.92
IMP2
Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
YLL052C 5.90
AQY2
Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YGL133W 5.88
ITC1
Component of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1
YDL210W 5.81
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YMR206W 5.78 Putative protein of unknown function; YMR206W is not an essential gene
YGR110W 5.72 Putative protein of unknown function; transcription is increased in response to genotoxic stress; plays a role in restricting Ty1 transposition
YEL009C 5.71
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YOR374W 5.69
ALD4
Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
YKL177W 5.67 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene STE3
YLR228C 5.64
ECM22
Sterol regulatory element binding protein, regulates transcription of the sterol biosynthetic genes ERG2 and ERG3; member of the fungus-specific Zn[2]-Cys[6] binuclear cluster family of transcription factors; homologous to Upc2p
YJR150C 5.60
DAN1
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YOL156W 5.59
HXT11
Putative hexose transporter that is nearly identical to Hxt9p, has similarity to major facilitator superfamily (MFS) transporters and is involved in pleiotropic drug resistance
YPR005C 5.59
HAL1
Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p
YBL064C 5.58
PRX1
Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress; phosphorylated
YDL245C 5.50
HXT15
Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose
YOL082W 5.49
ATG19
Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; recognizes cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) and delivers them to the preautophagosomal structure for packaging into Cvt vesicles
YLR402W 5.48 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR292W 5.47
MAL12
Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus
YHR212C 5.47 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR040W 5.46
YET2
Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
YMR081C 5.45
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YOR394W 5.37
PAU21
Hypothetical protein
YOR346W 5.36
REV1
Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YBR108W 5.35
AIM3
Protein interacting with Rsv167p; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YMR017W 5.34
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YAL063C 5.32
FLO9
Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
YLR403W 5.27
SFP1
Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
YBR054W 5.26
YRO2
Putative protein of unknown function; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p
YBL045C 5.25
COR1
Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain
YNL180C 5.25
RHO5
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
YER066W 5.24 Putative protein of unknown function; YER066W is not an essential gene
YDR374C 5.23 Putative protein of unknown function
YIL017C 5.21
VID28
Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm
YER084W 5.19 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR438W 5.16
CAR2
L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive
YDR542W 5.15
PAU10
Hypothetical protein
YOL060C 5.14
MAM3
Protein required for normal mitochondrial morphology, has similarity to hemolysins
YPL171C 5.11
OYE3
Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YDL215C 5.10
GDH2
NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels
YBL049W 5.09
MOH1
Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase
YEL039C 5.07
CYC7
Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YKL107W 5.03 Putative protein of unknown function
YBR132C 5.01
AGP2
High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease
YLR304C 5.00
ACO1
Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy
YHR212W-A 4.99 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YPR127W 4.98 Putative protein of unknown function; expression is activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YOR343C 4.97 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YNL179C 4.96 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
YLR259C 4.91
HSP60
Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated
YOR186W 4.88 Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent
YOR027W 4.82
STI1
Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones; activates the ATPase activity of Ssa1p; homolog of mammalian Hop protein
YEL052W 4.82
AFG1
Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain
YOR345C 4.75 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YLR121C 4.75
YPS3
Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YCR010C 4.73
ADY2
Acetate transporter required for normal sporulation; phosphorylated in mitochondria
YDR528W 4.72
HLR1
Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A
YLR366W 4.71 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A
YER076W-A 4.65 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER076C
YJR149W 4.64 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YBR218C 4.61
PYC2
Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosis
YDR036C 4.59
EHD3
3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis
YOL159C 4.59 Soluble protein of unknown function; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA
YEL010W 4.58 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNR034W-A 4.58 Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YDR342C 4.52
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YJL089W 4.46
SIP4
C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus
YER076C 4.46 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization
YNL077W 4.43
APJ1
Putative chaperone of the HSP40 (DNAJ) family; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR437C-A 4.41 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CAR2/YLR438W
YDR014W-A 4.39
HED1
Meiosis-specific protein that down-regulates Rad51p-mediated mitotic recombination when the meiotic recombination machinery is impaired; early meiotic gene, transcribed specifically during meiotic prophase
YGR250C 4.34 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YDR536W 4.32
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YKL178C 4.32
STE3
Receptor for a factor receptor, transcribed in alpha cells and required for mating by alpha cells, couples to MAP kinase cascade to mediate pheromone response; ligand bound receptors are endocytosed and recycled to the plasma membrane; GPCR
YBR145W 4.30
ADH5
Alcohol dehydrogenase isoenzyme V; involved in ethanol production
YPL165C 4.29
SET6
Protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability
YJR061W 4.27 Putative protein of unknown function; non-essential gene with similarity to Mnn4, a putative membrane protein involved in glycosylation; transcription repressed by Rm101p
YMR306W 4.26
FKS3
Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR381W 4.25
FRE3
Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
YGL222C 4.24
EDC1
RNA-binding protein, activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p
YLR377C 4.23
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YNR069C 4.22
BSC5
Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
YHR078W 4.14 High osmolarity-regulated gene of unknown function
YGL096W 4.14
TOS8
Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p
YEL070W 4.13
DSF1
Deletion suppressor of mpt5 mutation
YFL054C 4.11 Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol
YKL171W 3.96 Putative protein of unknown function; predicted protein kinase; implicated in proteasome function; epitope-tagged protein localizes to the cytoplasm
YGR258C 3.95
RAD2
Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
YDR441C 3.92
APT2
Apparent pseudogene, not transcribed or translated under normal conditions; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity
YPR192W 3.83
AQY1
Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance
YGR059W 3.83
SPR3
Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI
YNL190W 3.83 Cell wall protein of unknown function; proposed role as a hydrophilin induced by osmotic stress; contains a putative GPI-attachment site
YDL026W 3.82 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
YAL061W 3.79
BDH2
Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; BDH2 is an essential gene
YHR217C 3.78 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; located in the telomeric region TEL08R.
YAL060W 3.72
BDH1
NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source
YNL305C 3.71 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL305C is not an essential gene
YDR537C 3.71 Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
YMR164C 3.67
MSS11
Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of MUC1 and STA2 in response to nutritional signals
YPR196W 3.66 Putative maltose activator
YBR200W-A 3.62 Putative protein of unknown function; identified by fungal homology and RT-PCR
YOL051W 3.57
GAL11
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors
YDR525W-A 3.53
SNA2
Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YDR541C 3.53 Putative dihydrokaempferol 4-reductase
YEL012W 3.51
UBC8
Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
YOR382W 3.49
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YOR373W 3.48
NUD1
Component of the spindle pole body outer plaque, required for exit from mitosis
YPL271W 3.48
ATP15
Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YHR205W 3.45
SCH9
Protein kinase involved in transcriptional activation of osmostress-responsive genes; regulates G1 progression, cAPK activity, nitrogen activation of the FGM pathway; involved in life span regulation; homologous to mammalian Akt/PKB
YFL003C 3.45
MSH4
Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein
YDL027C 3.44 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL027C is not an essential gene
YDR223W 3.36
CRF1
Transcriptional corepressor involved in the regulation of ribosomal protein gene transcription via the TOR signaling pathway and protein kinase A, phosphorylated by activated Yak1p which promotes accumulation of Crf1p in the nucleus
YKL036C 3.35 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W
YJR004C 3.35
SAG1
Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor
YBL075C 3.32
SSA3
ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm
YOR177C 3.32
MPC54
Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate
YGL194C 3.31
HOS2
Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity
YKR040C 3.30 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W
YOR140W 3.29
SFL1
Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p
YML120C 3.28
NDI1
NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID

Network of associatons between targets according to the STRING database.

First level regulatory network of CIN5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.7 14.0 GO:0019676 ammonia assimilation cycle(GO:0019676)
4.5 40.9 GO:0006097 glyoxylate cycle(GO:0006097)
3.4 10.2 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
3.3 9.9 GO:0010133 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
2.9 8.8 GO:0006545 glycine biosynthetic process(GO:0006545)
2.8 8.5 GO:0036257 multivesicular body organization(GO:0036257)
2.6 15.9 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
2.6 7.8 GO:0006740 NADPH regeneration(GO:0006740)
2.6 7.8 GO:0006538 glutamate catabolic process(GO:0006538)
2.3 7.0 GO:0032780 negative regulation of ATPase activity(GO:0032780)
2.3 11.7 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
2.3 9.2 GO:0006848 pyruvate transport(GO:0006848)
2.2 4.5 GO:0061413 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
2.2 8.8 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
2.2 8.7 GO:0042357 thiamine diphosphate biosynthetic process(GO:0009229) thiamine diphosphate metabolic process(GO:0042357)
2.2 8.6 GO:0032371 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
2.1 8.3 GO:0006527 arginine catabolic process(GO:0006527)
1.9 13.3 GO:0000023 maltose metabolic process(GO:0000023)
1.8 3.6 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
1.8 8.9 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
1.7 15.2 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
1.7 11.7 GO:0043457 regulation of cellular respiration(GO:0043457)
1.6 8.1 GO:0046036 CTP biosynthetic process(GO:0006241) pyrimidine ribonucleoside triphosphate metabolic process(GO:0009208) pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209) CTP metabolic process(GO:0046036)
1.6 6.4 GO:0015847 putrescine transport(GO:0015847)
1.6 31.4 GO:0005978 glycogen biosynthetic process(GO:0005978)
1.6 21.9 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
1.5 13.9 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
1.5 3.1 GO:0072353 cellular age-dependent response to reactive oxygen species(GO:0072353)
1.5 4.5 GO:0070304 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
1.5 4.4 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
1.5 10.2 GO:0061393 positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress(GO:0061393)
1.3 1.3 GO:0061416 regulation of transcription from RNA polymerase II promoter in response to salt stress(GO:0061416)
1.3 6.6 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
1.3 3.9 GO:0044209 AMP salvage(GO:0044209)
1.3 5.2 GO:0032056 positive regulation of translation in response to stress(GO:0032056)
1.3 22.9 GO:0001101 response to acid chemical(GO:0001101)
1.3 11.3 GO:0045332 phospholipid translocation(GO:0045332)
1.2 2.4 GO:2000197 regulation of mRNA export from nucleus(GO:0010793) regulation of nucleobase-containing compound transport(GO:0032239) regulation of RNA export from nucleus(GO:0046831) regulation of ribonucleoprotein complex localization(GO:2000197)
1.2 12.9 GO:0006635 fatty acid beta-oxidation(GO:0006635)
1.2 1.2 GO:0036095 positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter(GO:0036095) positive regulation of invasive growth in response to glucose limitation(GO:2000219)
1.1 5.6 GO:0006083 acetate metabolic process(GO:0006083)
1.1 32.1 GO:0006094 gluconeogenesis(GO:0006094)
1.1 5.5 GO:0015793 glycerol transport(GO:0015793)
1.1 4.3 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
1.1 3.2 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
1.0 3.1 GO:0090630 activation of GTPase activity(GO:0090630)
1.0 9.0 GO:0006829 zinc II ion transport(GO:0006829)
1.0 3.0 GO:0043068 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
1.0 4.9 GO:0051099 positive regulation of binding(GO:0051099)
1.0 4.9 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
1.0 13.4 GO:0034087 establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087)
0.9 7.6 GO:0015891 siderophore transport(GO:0015891)
0.9 1.9 GO:1902222 L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.9 1.9 GO:0055075 cellular potassium ion homeostasis(GO:0030007) potassium ion homeostasis(GO:0055075)
0.9 0.9 GO:0000304 response to singlet oxygen(GO:0000304)
0.9 3.6 GO:0072337 modified amino acid transport(GO:0072337)
0.9 1.7 GO:0008272 sulfate transport(GO:0008272)
0.8 3.3 GO:0098609 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.8 7.4 GO:0045996 negative regulation of transcription by pheromones(GO:0045996) negative regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046020)
0.8 2.4 GO:0000101 sulfur amino acid transport(GO:0000101)
0.8 11.2 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.8 3.2 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.8 3.9 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.8 2.4 GO:0042843 D-xylose catabolic process(GO:0042843)
0.8 1.6 GO:0015740 C4-dicarboxylate transport(GO:0015740)
0.8 5.3 GO:0006855 drug transmembrane transport(GO:0006855)
0.7 2.2 GO:0019543 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
0.7 2.9 GO:0019405 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.7 2.8 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.7 2.1 GO:0034762 regulation of transmembrane transport(GO:0034762)
0.7 2.1 GO:0022610 cell adhesion(GO:0007155) biological adhesion(GO:0022610)
0.7 0.7 GO:0010676 positive regulation of cellular carbohydrate metabolic process(GO:0010676) positive regulation of carbohydrate metabolic process(GO:0045913)
0.7 2.8 GO:0032108 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.7 9.0 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.7 7.2 GO:0046686 response to cadmium ion(GO:0046686)
0.6 1.9 GO:0005993 trehalose catabolic process(GO:0005993)
0.6 4.4 GO:0055071 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.6 1.9 GO:0009450 gamma-aminobutyric acid metabolic process(GO:0009448) gamma-aminobutyric acid catabolic process(GO:0009450)
0.6 5.6 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.6 2.5 GO:0045764 positive regulation of cellular amino acid metabolic process(GO:0045764) positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.6 1.2 GO:0042732 D-xylose metabolic process(GO:0042732)
0.6 1.7 GO:0015976 carbon utilization(GO:0015976)
0.5 4.8 GO:0000710 meiotic mismatch repair(GO:0000710)
0.5 1.6 GO:0042407 cristae formation(GO:0042407)
0.5 3.1 GO:0071322 cellular response to carbohydrate stimulus(GO:0071322)
0.5 5.1 GO:0006067 ethanol metabolic process(GO:0006067)
0.5 1.0 GO:0051260 protein homooligomerization(GO:0051260)
0.5 2.0 GO:0000431 regulation of transcription from RNA polymerase II promoter by galactose(GO:0000431) positive regulation of transcription from RNA polymerase II promoter by galactose(GO:0000435)
0.5 2.0 GO:0051865 protein autoubiquitination(GO:0051865) protein localization to bud neck(GO:0097271)
0.5 1.5 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
0.5 5.4 GO:0006101 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101)
0.5 1.5 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.5 1.9 GO:0032781 positive regulation of ATPase activity(GO:0032781) regulation of ATPase activity(GO:0043462)
0.5 2.4 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.5 1.9 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.5 3.7 GO:0000755 cytogamy(GO:0000755)
0.5 19.3 GO:0009060 aerobic respiration(GO:0009060)
0.5 1.4 GO:0046160 heme a biosynthetic process(GO:0006784) heme a metabolic process(GO:0046160)
0.5 1.4 GO:0009062 fatty acid catabolic process(GO:0009062)
0.4 5.8 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.4 2.7 GO:0046352 disaccharide catabolic process(GO:0046352)
0.4 2.7 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.4 2.2 GO:0003400 regulation of COPII vesicle coating(GO:0003400) regulation of vesicle targeting, to, from or within Golgi(GO:0048209) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.4 1.8 GO:0046323 glucose import(GO:0046323)
0.4 1.3 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.4 1.3 GO:0009065 glutamine family amino acid catabolic process(GO:0009065)
0.4 0.9 GO:0008615 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.4 0.4 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.4 2.4 GO:0043605 cellular amide catabolic process(GO:0043605)
0.4 2.4 GO:0007532 regulation of mating-type specific transcription, DNA-templated(GO:0007532)
0.4 3.2 GO:0006641 neutral lipid metabolic process(GO:0006638) acylglycerol metabolic process(GO:0006639) triglyceride metabolic process(GO:0006641)
0.4 8.1 GO:0032258 CVT pathway(GO:0032258)
0.4 2.3 GO:0015851 nucleobase transport(GO:0015851)
0.4 3.0 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.4 1.1 GO:0006598 polyamine catabolic process(GO:0006598)
0.4 7.5 GO:0098660 inorganic ion transmembrane transport(GO:0098660)
0.4 2.1 GO:0045117 azole transport(GO:0045117)
0.3 0.7 GO:0031138 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.3 4.8 GO:0000147 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.3 1.0 GO:1903339 inactivation of MAPK activity involved in cell wall organization or biogenesis(GO:0000200) regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903137) negative regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903138) negative regulation of cell wall organization or biogenesis(GO:1903339)
0.3 3.1 GO:0070987 error-free translesion synthesis(GO:0070987)
0.3 1.3 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.3 1.0 GO:0034091 regulation of maintenance of sister chromatid cohesion(GO:0034091)
0.3 0.3 GO:0034308 primary alcohol metabolic process(GO:0034308)
0.3 0.7 GO:0000019 regulation of mitotic recombination(GO:0000019)
0.3 0.6 GO:0006754 ATP biosynthetic process(GO:0006754)
0.3 1.3 GO:0015893 drug transport(GO:0015893)
0.3 0.9 GO:0008216 spermidine metabolic process(GO:0008216)
0.3 1.2 GO:0008053 mitochondrial fusion(GO:0008053)
0.3 16.9 GO:0007031 peroxisome organization(GO:0007031)
0.3 5.3 GO:0022406 membrane docking(GO:0022406) vesicle docking(GO:0048278)
0.3 7.3 GO:0006312 mitotic recombination(GO:0006312)
0.3 0.6 GO:0006167 AMP biosynthetic process(GO:0006167) AMP metabolic process(GO:0046033)
0.3 2.8 GO:0016925 protein sumoylation(GO:0016925)
0.3 1.4 GO:2000279 negative regulation of DNA biosynthetic process(GO:2000279)
0.3 1.1 GO:0060237 regulation of fungal-type cell wall organization(GO:0060237)
0.3 4.1 GO:0006895 Golgi to endosome transport(GO:0006895)
0.3 1.3 GO:0019722 calcium-mediated signaling(GO:0019722)
0.3 1.5 GO:0006465 signal peptide processing(GO:0006465)
0.2 1.7 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.2 1.5 GO:0006771 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.2 0.5 GO:0008105 asymmetric protein localization(GO:0008105)
0.2 0.7 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.2 25.5 GO:0045229 external encapsulating structure organization(GO:0045229) cell wall organization(GO:0071555)
0.2 0.9 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.2 1.1 GO:0032973 amino acid export(GO:0032973) amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.2 0.2 GO:0015688 iron chelate transport(GO:0015688)
0.2 1.9 GO:0051181 cofactor transport(GO:0051181)
0.2 0.6 GO:0001178 regulation of transcriptional start site selection at RNA polymerase II promoter(GO:0001178)
0.2 0.4 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.2 4.1 GO:0008645 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.2 0.2 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.2 1.2 GO:1901658 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.2 0.6 GO:0017003 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.2 1.7 GO:0015802 basic amino acid transport(GO:0015802)
0.2 1.5 GO:0042766 nucleosome mobilization(GO:0042766)
0.2 0.9 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.2 0.5 GO:2000001 regulation of cell cycle checkpoint(GO:1901976) negative regulation of cell cycle checkpoint(GO:1901977) regulation of DNA damage checkpoint(GO:2000001) negative regulation of DNA damage checkpoint(GO:2000002) negative regulation of response to DNA damage stimulus(GO:2001021)
0.2 1.0 GO:0006071 glycerol metabolic process(GO:0006071) alditol metabolic process(GO:0019400)
0.2 1.2 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.2 1.1 GO:0006826 iron ion transport(GO:0006826)
0.2 0.5 GO:0050685 positive regulation of mRNA processing(GO:0050685)
0.1 0.4 GO:0035459 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.1 1.6 GO:0000742 karyogamy involved in conjugation with cellular fusion(GO:0000742)
0.1 0.4 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.1 0.4 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.1 1.6 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 0.9 GO:0048309 endoplasmic reticulum inheritance(GO:0048309)
0.1 0.5 GO:0019935 cAMP-mediated signaling(GO:0019933) cyclic-nucleotide-mediated signaling(GO:0019935)
0.1 0.4 GO:0071281 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.1 1.2 GO:0051293 establishment of spindle localization(GO:0051293) spindle localization(GO:0051653)
0.1 0.6 GO:0000196 MAPK cascade involved in cell wall organization or biogenesis(GO:0000196)
0.1 0.6 GO:0034354 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.1 1.7 GO:0000209 protein polyubiquitination(GO:0000209)
0.1 0.6 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.1 1.0 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.1 0.7 GO:0006452 translational frameshifting(GO:0006452)
0.1 0.3 GO:0006449 regulation of translational termination(GO:0006449)
0.1 1.7 GO:0016579 protein deubiquitination(GO:0016579)
0.1 0.4 GO:0035753 maintenance of DNA trinucleotide repeats(GO:0035753)
0.1 0.6 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.1 0.6 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.1 0.3 GO:0000390 spliceosomal complex disassembly(GO:0000390)
0.1 0.4 GO:0000161 MAPK cascade involved in osmosensory signaling pathway(GO:0000161)
0.1 0.2 GO:0031047 gene silencing involved in chronological cell aging(GO:0010978) gene silencing by RNA(GO:0031047)
0.1 0.3 GO:0009410 response to xenobiotic stimulus(GO:0009410)
0.1 0.4 GO:0001041 transcription from RNA polymerase III type 2 promoter(GO:0001009) transcription from a RNA polymerase III hybrid type promoter(GO:0001041)
0.1 0.3 GO:0005984 disaccharide metabolic process(GO:0005984)
0.1 0.8 GO:0006031 aminoglycan biosynthetic process(GO:0006023) chitin biosynthetic process(GO:0006031) glucosamine-containing compound biosynthetic process(GO:1901073)
0.1 0.3 GO:0071041 antisense RNA transcript catabolic process(GO:0071041)
0.1 0.4 GO:0006089 lactate metabolic process(GO:0006089)
0.1 0.4 GO:0006813 potassium ion transport(GO:0006813)
0.1 0.4 GO:0070941 eisosome assembly(GO:0070941)
0.1 0.4 GO:0018202 peptidyl-histidine modification(GO:0018202)
0.1 0.5 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.1 0.8 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.1 0.2 GO:2000217 regulation of invasive growth in response to glucose limitation(GO:2000217)
0.1 0.3 GO:0002183 cytoplasmic translational initiation(GO:0002183)
0.1 0.5 GO:0035268 protein mannosylation(GO:0035268) protein O-linked mannosylation(GO:0035269) mannosylation(GO:0097502)
0.1 0.2 GO:0046466 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.1 0.1 GO:0032365 intracellular lipid transport(GO:0032365)
0.1 0.1 GO:0090295 nitrogen catabolite repression of transcription(GO:0090295)
0.1 0.2 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.1 0.8 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 0.3 GO:0043409 negative regulation of MAPK cascade(GO:0043409)
0.1 0.3 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.1 2.2 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.5 GO:0016575 histone deacetylation(GO:0016575)
0.0 0.3 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.0 0.2 GO:0006621 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.0 0.3 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0 0.4 GO:0070129 regulation of mitochondrial translation(GO:0070129)
0.0 0.6 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.1 GO:0071850 mitotic cell cycle arrest in response to pheromone(GO:0000751) mitotic cell cycle arrest(GO:0071850)
0.0 0.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.3 GO:0015914 phospholipid transport(GO:0015914)
0.0 0.1 GO:0071709 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.0 0.2 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 2.1 GO:0032543 mitochondrial translation(GO:0032543)
0.0 1.7 GO:0030435 sporulation resulting in formation of a cellular spore(GO:0030435)
0.0 0.1 GO:0042256 mature ribosome assembly(GO:0042256)
0.0 0.1 GO:0002376 immune effector process(GO:0002252) immune system process(GO:0002376) response to virus(GO:0009615) response to external biotic stimulus(GO:0043207) defense response to virus(GO:0051607) response to other organism(GO:0051707) defense response to other organism(GO:0098542)
0.0 0.1 GO:0000767 cell morphogenesis involved in conjugation with cellular fusion(GO:0000753) cell morphogenesis involved in conjugation(GO:0000767)
0.0 0.1 GO:0031081 nuclear pore distribution(GO:0031081) nuclear pore localization(GO:0051664)
0.0 0.1 GO:0009102 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.0 0.1 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 10.9 GO:0032585 multivesicular body membrane(GO:0032585)
3.5 14.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)
2.8 33.0 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
2.4 9.7 GO:0000817 COMA complex(GO:0000817)
2.3 11.7 GO:0045273 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
2.2 6.6 GO:0045269 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
2.0 5.9 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
1.8 5.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
1.8 14.4 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
1.5 5.9 GO:0008623 CHRAC(GO:0008623)
1.4 12.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
1.1 6.9 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
1.1 14.8 GO:0070469 respiratory chain(GO:0070469)
1.1 4.3 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
1.0 3.0 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
1.0 46.0 GO:0031225 anchored component of membrane(GO:0031225)
0.8 1.7 GO:0001400 mating projection base(GO:0001400)
0.8 5.7 GO:0034657 GID complex(GO:0034657)
0.8 2.4 GO:0045265 mitochondrial proton-transporting ATP synthase, stator stalk(GO:0000274) proton-transporting ATP synthase, stator stalk(GO:0045265)
0.7 3.7 GO:0072380 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.7 4.9 GO:0034967 Set3 complex(GO:0034967)
0.7 6.3 GO:0000795 synaptonemal complex(GO:0000795)
0.7 1.4 GO:0032389 MutLalpha complex(GO:0032389)
0.7 2.7 GO:0097002 mitochondrial inner boundary membrane(GO:0097002)
0.7 17.0 GO:0005887 integral component of plasma membrane(GO:0005887)
0.6 3.9 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.5 3.8 GO:0031105 septin complex(GO:0031105)
0.5 1.6 GO:0032177 split septin rings(GO:0032176) cellular bud neck split septin rings(GO:0032177)
0.5 1.6 GO:0044284 mitochondrial crista junction(GO:0044284)
0.5 4.1 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.5 2.0 GO:0030139 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128) endocytic vesicle(GO:0030139) endocytic vesicle membrane(GO:0030666) clathrin-coated endocytic vesicle membrane(GO:0030669) clathrin-coated endocytic vesicle(GO:0045334)
0.5 11.5 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.4 1.3 GO:0032301 MutSalpha complex(GO:0032301)
0.4 0.4 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.4 1.2 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.4 15.5 GO:0005576 extracellular region(GO:0005576)
0.4 1.1 GO:0070211 Snt2C complex(GO:0070211)
0.3 2.0 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.3 14.6 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.3 0.9 GO:0030896 checkpoint clamp complex(GO:0030896)
0.3 3.0 GO:0005769 early endosome(GO:0005769)
0.3 1.1 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.3 36.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.3 0.8 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.2 0.9 GO:0005825 half bridge of spindle pole body(GO:0005825)
0.2 0.6 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.2 0.6 GO:0030874 nucleolar chromatin(GO:0030874)
0.2 1.4 GO:0005619 ascospore wall(GO:0005619)
0.2 1.8 GO:0009277 fungal-type cell wall(GO:0009277)
0.2 0.8 GO:0070772 PAS complex(GO:0070772)
0.2 0.8 GO:0005869 dynactin complex(GO:0005869)
0.1 0.6 GO:0032126 eisosome(GO:0032126)
0.1 2.7 GO:0098552 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.1 0.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 2.7 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 2.3 GO:0070847 core mediator complex(GO:0070847)
0.1 1.1 GO:0000974 Prp19 complex(GO:0000974)
0.1 0.1 GO:0071014 U2-type post-mRNA release spliceosomal complex(GO:0071008) post-mRNA release spliceosomal complex(GO:0071014)
0.1 0.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.2 GO:0071007 U2-type catalytic step 2 spliceosome(GO:0071007) catalytic step 2 spliceosome(GO:0071013)
0.1 0.3 GO:0070274 RES complex(GO:0070274)
0.1 0.3 GO:0035649 Nrd1 complex(GO:0035649)
0.1 0.6 GO:0016459 myosin complex(GO:0016459)
0.1 2.0 GO:0042764 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.1 1.3 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 49.0 GO:0005739 mitochondrion(GO:0005739)
0.1 13.6 GO:0000324 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.1 0.3 GO:0098589 clathrin-coated pit(GO:0005905) membrane region(GO:0098589)
0.1 0.2 GO:0070823 HDA1 complex(GO:0070823)
0.1 0.3 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 3.2 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 4.0 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 0.4 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.1 0.3 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.1 21.0 GO:0005886 plasma membrane(GO:0005886)
0.1 0.6 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 1.4 GO:0019898 extrinsic component of membrane(GO:0019898)
0.1 0.8 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 0.3 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.3 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.1 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.0 0.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.1 GO:0042788 polysomal ribosome(GO:0042788)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 25.8 GO:0015295 solute:proton symporter activity(GO:0015295)
4.8 19.1 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
3.8 15.0 GO:0005537 mannose binding(GO:0005537)
3.5 10.6 GO:0016289 CoA hydrolase activity(GO:0016289)
3.5 10.4 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
3.4 10.2 GO:0016406 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
3.1 9.4 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
2.8 8.5 GO:0048038 quinone binding(GO:0048038)
2.7 8.2 GO:0008902 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
2.7 8.2 GO:0004575 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
2.6 13.1 GO:0008198 ferrous iron binding(GO:0008198)
2.6 20.5 GO:0031072 heat shock protein binding(GO:0031072)
2.3 11.3 GO:0050253 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
2.2 15.7 GO:0016833 oxo-acid-lyase activity(GO:0016833)
2.2 10.8 GO:0015294 solute:cation symporter activity(GO:0015294)
2.1 22.6 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
1.7 5.2 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
1.7 1.7 GO:0005057 receptor signaling protein activity(GO:0005057)
1.5 12.2 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
1.5 18.1 GO:0005199 structural constituent of cell wall(GO:0005199)
1.5 8.8 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
1.4 4.3 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
1.4 4.1 GO:0008137 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
1.4 4.1 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
1.3 1.3 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
1.2 9.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
1.2 12.3 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
1.2 3.6 GO:0004930 G-protein coupled receptor activity(GO:0004930)
1.2 4.6 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
1.2 4.6 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
1.1 3.3 GO:0050839 cell adhesion molecule binding(GO:0050839)
1.1 12.9 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
1.1 3.2 GO:0016878 AMP binding(GO:0016208) CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
1.1 1.1 GO:0004864 protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
1.0 3.1 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
1.0 3.0 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
1.0 3.0 GO:0090599 alpha-glucosidase activity(GO:0090599)
1.0 10.9 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
1.0 4.9 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.9 2.8 GO:0015385 sodium:proton antiporter activity(GO:0015385)
0.9 2.8 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.9 2.7 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.9 16.4 GO:0016831 carboxy-lyase activity(GO:0016831)
0.8 5.1 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.8 2.5 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.8 11.7 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors(GO:0016645)
0.8 6.6 GO:0016679 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.8 3.3 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.8 40.0 GO:0001228 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.8 3.2 GO:0016531 copper chaperone activity(GO:0016531)
0.8 4.0 GO:0045118 azole transporter activity(GO:0045118)
0.8 4.6 GO:0005354 galactose transmembrane transporter activity(GO:0005354)
0.7 2.2 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.7 3.5 GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)(GO:0097372)
0.7 9.2 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.7 7.7 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.7 1.4 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.7 4.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.6 1.9 GO:0004555 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.6 1.8 GO:0070569 uridylyltransferase activity(GO:0070569)
0.6 2.4 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.6 1.7 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.6 3.9 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.6 6.2 GO:0030983 mismatched DNA binding(GO:0030983)
0.6 2.2 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.5 1.6 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.5 4.5 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.5 3.9 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.5 1.5 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.5 4.4 GO:0099600 transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) transmembrane receptor activity(GO:0099600)
0.5 2.8 GO:0016408 C-acyltransferase activity(GO:0016408)
0.5 5.6 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.5 7.0 GO:0008236 serine-type peptidase activity(GO:0008236)
0.5 6.5 GO:0015297 antiporter activity(GO:0015297)
0.5 3.7 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.5 1.4 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.5 0.5 GO:0005078 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.4 1.3 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.4 0.9 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.4 1.6 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.4 1.2 GO:0015293 symporter activity(GO:0015293)
0.4 2.3 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.4 1.5 GO:0004396 hexokinase activity(GO:0004396)
0.4 1.9 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.4 3.8 GO:0016684 peroxidase activity(GO:0004601) oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)
0.4 1.9 GO:0019104 DNA N-glycosylase activity(GO:0019104)
0.4 6.5 GO:0016769 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.4 1.4 GO:0019776 Atg8 ligase activity(GO:0019776)
0.4 4.9 GO:0019205 nucleobase-containing compound kinase activity(GO:0019205)
0.4 0.4 GO:0004075 biotin carboxylase activity(GO:0004075)
0.3 3.1 GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism(GO:0015662)
0.3 1.0 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.3 1.7 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.3 4.8 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.3 1.9 GO:0051184 cofactor transporter activity(GO:0051184)
0.3 5.9 GO:0008301 DNA binding, bending(GO:0008301)
0.3 0.9 GO:0000156 phosphorelay response regulator activity(GO:0000156)
0.3 2.5 GO:0010181 FMN binding(GO:0010181)
0.3 1.2 GO:0000400 four-way junction DNA binding(GO:0000400)
0.3 0.8 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.3 1.1 GO:0016411 acylglycerol O-acyltransferase activity(GO:0016411)
0.3 1.4 GO:0016782 transferase activity, transferring sulfur-containing groups(GO:0016782) sulfurtransferase activity(GO:0016783)
0.3 4.9 GO:0051087 chaperone binding(GO:0051087)
0.3 1.4 GO:0019789 SUMO transferase activity(GO:0019789)
0.3 2.4 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.3 1.0 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.3 0.3 GO:0001005 RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003) transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting(GO:0001004) transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIB recruiting(GO:0001005) transcription factor activity, RNA polymerase III type 2 promoter sequence-specific binding, TFIIIB recruiting(GO:0001008) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034)
0.3 0.5 GO:0019902 phosphatase binding(GO:0019902) protein phosphatase binding(GO:0019903)
0.2 1.0 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.2 1.0 GO:0042927 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.2 1.0 GO:0008172 S-methyltransferase activity(GO:0008172)
0.2 0.7 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.2 0.9 GO:0042973 glucan exo-1,3-beta-glucosidase activity(GO:0004338) glucan endo-1,3-beta-D-glucosidase activity(GO:0042973)
0.2 1.8 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.2 1.8 GO:0005507 copper ion binding(GO:0005507)
0.2 1.1 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.2 1.1 GO:0015923 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.2 1.0 GO:0017022 myosin binding(GO:0017022)
0.2 0.8 GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813)
0.2 2.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.2 1.0 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.2 1.9 GO:0035064 methylated histone binding(GO:0035064)
0.2 1.2 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.2 0.5 GO:0015203 polyamine transmembrane transporter activity(GO:0015203)
0.2 0.7 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.2 0.7 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.2 4.7 GO:0008234 cysteine-type peptidase activity(GO:0008234)
0.2 0.8 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.2 1.7 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 1.8 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.1 0.4 GO:0004457 lactate dehydrogenase activity(GO:0004457) D-lactate dehydrogenase (cytochrome) activity(GO:0004458) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
0.1 0.6 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 0.4 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 0.6 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.1 0.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 0.4 GO:0033592 RNA strand annealing activity(GO:0033592) annealing activity(GO:0097617)
0.1 0.5 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.1 3.2 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.1 0.6 GO:0000146 microfilament motor activity(GO:0000146)
0.1 0.4 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.1 1.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.1 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.1 0.4 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.1 1.4 GO:0045182 translation regulator activity(GO:0045182)
0.1 1.7 GO:0043022 ribosome binding(GO:0043022)
0.1 0.3 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.1 0.2 GO:0001094 RNA polymerase II basal transcription factor binding(GO:0001091) TFIID-class transcription factor binding(GO:0001094)
0.1 1.2 GO:0022838 substrate-specific channel activity(GO:0022838)
0.1 0.4 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 0.3 GO:0004805 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825) trehalose-phosphatase activity(GO:0004805)
0.1 0.6 GO:0005548 phospholipid transporter activity(GO:0005548)
0.1 0.3 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.1 0.1 GO:0072341 modified amino acid binding(GO:0072341)
0.1 1.9 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 0.2 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
0.1 7.9 GO:0004672 protein kinase activity(GO:0004672)
0.1 2.4 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 0.3 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.1 0.6 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.1 0.8 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 0.7 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 0.3 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.1 0.6 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 0.1 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.1 0.3 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.6 GO:0032947 protein complex scaffold(GO:0032947)
0.0 0.2 GO:0003712 transcription cofactor activity(GO:0003712)
0.0 1.1 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.1 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.0 0.1 GO:0015188 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.0 0.0 GO:0004180 carboxypeptidase activity(GO:0004180)
0.0 0.1 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 0.1 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0 1.5 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 0.2 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.1 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.0 GO:0004364 glutathione transferase activity(GO:0004364)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
6.8 20.3 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
4.7 14.2 PID IL4 2PATHWAY IL4-mediated signaling events
0.8 2.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.6 1.2 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.4 1.3 PID AR PATHWAY Coregulation of Androgen receptor activity
0.3 411.2 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.3 1.3 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.2 0.9 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 0.5 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 0.1 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 21.3 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
1.4 4.1 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
1.2 3.6 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.8 3.2 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.5 3.4 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.5 1.9 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.4 3.6 REACTOME DNA REPAIR Genes involved in DNA Repair
0.4 0.8 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.3 0.8 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.3 400.8 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.2 0.4 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.1 0.7 REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE Genes involved in NGF signalling via TRKA from the plasma membrane
0.1 0.2 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 1.4 REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS Genes involved in Metabolism of lipids and lipoproteins
0.0 0.3 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 0.2 REACTOME HEMOSTASIS Genes involved in Hemostasis
0.0 0.3 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation