Results for CAT8
Z-value: 1.24
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Transcription factors associated with CAT8
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
CAT8
|
S000004893 | Zinc cluster transcriptional activator |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YFR055W Show fit | 38.64 |
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner |
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| YFR056C Show fit | 32.28 |
Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W |
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| YLR154W-A Show fit | 28.29 |
Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand |
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| YLR154W-B Show fit | 27.22 |
Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand |
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| YLR154C Show fit | 26.63 |
Ribonuclease H2 subunit, required for RNase H2 activity |
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| YNL178W Show fit | 20.79 |
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins |
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| YLR154W-C Show fit | 18.95 |
Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand |
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| YDR098C Show fit | 16.03 |
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage |
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| YER131W Show fit | 13.44 |
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein |
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| YDR345C Show fit | 11.10 |
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions |
Network of associatons between targets according to the STRING database.
First level regulatory network of CAT8
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 85.8 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 2.7 | 48.5 | GO:0051029 | rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029) |
| 12.9 | 38.6 | GO:0000098 | sulfur amino acid catabolic process(GO:0000098) |
| 4.5 | 31.8 | GO:0043137 | DNA replication, removal of RNA primer(GO:0043137) |
| 0.9 | 22.3 | GO:0002098 | tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098) |
| 2.9 | 17.4 | GO:0009099 | valine biosynthetic process(GO:0009099) |
| 1.6 | 14.4 | GO:0000947 | amino acid catabolic process to alcohol via Ehrlich pathway(GO:0000947) |
| 0.3 | 14.2 | GO:0055072 | iron ion homeostasis(GO:0055072) |
| 0.1 | 13.0 | GO:0006364 | rRNA processing(GO:0006364) |
| 1.8 | 12.7 | GO:0043457 | regulation of cellular respiration(GO:0043457) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 79.6 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.8 | 48.4 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 10.4 | 31.2 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.1 | 25.6 | GO:0005933 | cellular bud(GO:0005933) |
| 1.8 | 21.3 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 0.4 | 20.3 | GO:0030686 | 90S preribosome(GO:0030686) |
| 0.3 | 15.1 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.2 | 9.1 | GO:0044445 | cytosolic part(GO:0044445) |
| 0.0 | 9.0 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 1.3 | 7.8 | GO:0005871 | kinesin complex(GO:0005871) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 117.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 5.3 | 31.8 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 7.8 | 31.2 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 3.5 | 20.9 | GO:0003906 | DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906) |
| 1.4 | 18.4 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.5 | 14.6 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 2.4 | 14.5 | GO:0004022 | alcohol dehydrogenase (NAD) activity(GO:0004022) |
| 0.5 | 14.5 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 2.9 | 11.8 | GO:0000297 | spermine transmembrane transporter activity(GO:0000297) |
| 0.8 | 10.5 | GO:0003746 | translation elongation factor activity(GO:0003746) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 9.3 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.6 | 1.8 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.3 | 1.2 | PID E2F PATHWAY | E2F transcription factor network |
| 0.4 | 1.1 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.2 | 1.0 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 0.7 | PID ATR PATHWAY | ATR signaling pathway |
| 0.6 | 0.6 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.1 | 0.6 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.2 | 0.5 | PID MYC PATHWAY | C-MYC pathway |
| 0.4 | 0.4 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 24.5 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 0.0 | 18.4 | REACTOME GLYCOSAMINOGLYCAN METABOLISM | Genes involved in Glycosaminoglycan metabolism |
| 1.1 | 18.2 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 3.4 | 10.2 | REACTOME SIGNALLING TO ERKS | Genes involved in Signalling to ERKs |
| 1.0 | 7.2 | REACTOME METABOLISM OF MRNA | Genes involved in Metabolism of mRNA |
| 1.2 | 4.7 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 2.1 | 4.2 | REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |
| 0.4 | 2.7 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.6 | 1.8 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.2 | 1.7 | REACTOME SIGNALING BY GPCR | Genes involved in Signaling by GPCR |