Navigation
Downloads

Results for CAD1

Z-value: 1.61

Motif logo

logo of

Transcription factors associated with CAD1

Gene Symbol Gene ID Gene Info
CAD1
S000002831 AP-1-like basic leucine zipper (bZIP) transcriptional activator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
CAD1YDR423C0.949.6e-13Click!

Activity profile of CAD1 motif

Sorted Z-values of CAD1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YPL171C 15.22
OYE3
Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YFL055W 10.04
AGP3
Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition
YNL195C 8.88 Putative protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YAR050W 8.45
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YHR139C 8.00
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YOR382W 7.82
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YOR100C 7.74
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YLR296W 7.67 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHL040C 7.51
ARN1
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores
YCR007C 7.39 Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YDR277C 7.29
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YKL086W 7.21
SRX1
Sulfiredoxin, contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxins Tsa1p and Ahp1p that are formed upon exposure to oxidants; conserved in higher eukaryotes
YKL071W 7.14 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YIL057C 6.91 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YAR047C 6.81 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLL053C 6.74 Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YLR402W 6.68 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNR034W-A 6.43 Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YLR403W 6.34
SFP1
Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
YLL052C 5.99
AQY2
Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YLR295C 5.80
ATP14
Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YDR542W 5.53
PAU10
Hypothetical protein
YPL223C 5.50
GRE1
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YKL103C 5.33
LAP4
Vacuolar aminopeptidase, often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway
YOR120W 5.26
GCY1
Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family
YDL204W 5.16
RTN2
Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily
YOR152C 4.95 Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YOR072W 4.74 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YKL102C 4.72 Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
YJL103C 4.70
GSM1
Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis
YKL162C 4.63 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
YNL025C 4.55
SSN8
Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance
YNL125C 4.51
ESBP6
Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
YHR008C 4.50
SOD2
Mitochondrial superoxide dismutase, protects cells against oxygen toxicity; phosphorylated
YGR225W 4.48
AMA1
Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis
YDR453C 4.28
TSA2
Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants
YJR138W 4.25
IML1
Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane
YAL002W 4.20
VPS8
Membrane-associated protein that interacts with Vps21p to facilitate soluble vacuolar protein localization; component of the CORVET complex; required for localization and trafficking of the CPY sorting receptor; contains RING finger motif
YAL062W 4.02
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YLR149C 4.01 Putative protein of unknown function; YLR149C is not an essential gene
YGR065C 3.89
VHT1
High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
YOR072W-A 3.86 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR072W; originally identified by fungal homology and RT-PCR
YER014C-A 3.85
BUD25
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YML131W 3.84 Putative protein of unknown function with similarity to oxidoreductases; HOG1 and SKO1-dependent mRNA expression is induced after osmotic shock; GFP-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS
YOR071C 3.77
NRT1
High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
YGR144W 3.76
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YDR055W 3.59
PST1
Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1
YHR048W 3.57
YHK8
Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
YMR107W 3.50
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YFL052W 3.49 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YJR137C 3.48
ECM17
Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
YLL060C 3.40
GTT2
Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p
YLR297W 3.39 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YLR297W is not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation
YBR008C 3.36
FLR1
Plasma membrane multidrug transporter of the major facilitator superfamily, involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs
YDR258C 3.31
HSP78
Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; prevents the aggregation of misfolded matrix proteins; component of the mitochondrial proteolysis system
YPR078C 3.23 Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible
YOL159C 3.18 Soluble protein of unknown function; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA
YDL218W 3.17 Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions
YBR117C 3.14
TKL2
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YDR533C 3.14
HSP31
Possible chaperone and cysteine protease with similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site
YDL020C 3.08
RPN4
Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses
YDL243C 3.05
AAD4
Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase, involved in the oxidative stress response
YBL060W 3.02
YEL1
Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip
YER167W 3.00
BCK2
Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations
YNR063W 2.96 Putative zinc-cluster protein of unknown function
YJL102W 2.95
MEF2
Mitochondrial elongation factor involved in translational elongation
YGL184C 2.93
STR3
Cystathionine beta-lyase, converts cystathionine into homocysteine
YER141W 2.90
COX15
Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
YEL009C-A 2.87 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YAL018C 2.83 Putative protein of unknown function
YEL008W 2.81 Hypothetical protein predicted to be involved in metabolism
YNL093W 2.78
YPT53
GTPase, similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis
YLL056C 2.77 Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene
YDR541C 2.75 Putative dihydrokaempferol 4-reductase
YOR065W 2.73
CYT1
Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
YFL051C 2.73 Putative protein of unknown function; YFL051C is not an essential gene
YPR111W 2.72
DBF20
Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis
YEL009C 2.70
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YLR247C 2.69
IRC20
Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci
YOL050C 2.69 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YOL025W 2.68
LAG2
Protein involved in determination of longevity; LAG2 gene is preferentially expressed in young cells; overexpression extends the mean and maximum life span of cells
YCL048W 2.61
SPS22
Protein of unknown function, redundant with Sps2p for the organization of the beta-glucan layer of the spore wall
YJL163C 2.60 Putative protein of unknown function
YJL100W 2.60
LSB6
Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
YHR015W 2.58
MIP6
Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export
YPR036W-A 2.57 Protein of unknown function; transcription is regulated by Pdr1p
YPR023C 2.54
EAF3
Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition
YOR227W 2.52 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOL128C 2.52
YGK3
Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation
YDL214C 2.49
PRR2
Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
YAL067C 2.48
SEO1
Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
YGL114W 2.46 Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YLR299W 2.45
ECM38
Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation
YOR228C 2.40 Protein of unknown function, localized to the mitochondrial outer membrane
YGL090W 2.39
LIF1
Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
YPR013C 2.35 Putative zinc finger protein; YPR013C is not an essential gene
YAL039C 2.34
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YHR102W 2.31
KIC1
Protein kinase of the PAK/Ste20 kinase family, required for cell integrity possibly through regulating 1,6-beta-glucan levels in the wall; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body
YCR021C 2.30
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YKL044W 2.29 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER147C 2.26
SCC4
Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX
YDR169C 2.23
STB3
Protein that binds Sin3p in a two-hybrid assay
YNL331C 2.21
AAD14
Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role
YHR006W 2.20
STP2
Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes
YPL222W 2.19
FMP40
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR387C 2.19 Putative protein of unknown function; regulated by the metal-responsive Aft1p transcription factor; highly inducible in zinc-depleted conditions; localizes to the soluble fraction
YML087C 2.16
AIM33
Putative protein of unknown function; highly conserved across species and orthologous to human CYB5R4; null mutant shows increased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YBR047W 2.13
FMP23
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YCL017C 2.12
NFS1
Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis; required for the post-transcriptional thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria
YAL054C 2.12
ACS1
Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YOR223W 2.11 Putative protein of unknown function
YLR135W 2.10
SLX4
Subunit of a complex, with Slx1p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p
YGL180W 2.08
ATG1
Protein serine/threonine kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for pre-autophagosome formation; during autophagy forms a complex with Atg13p and Atg17p
YLL055W 2.08
YCT1
High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
YKL217W 2.07
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YGR258C 2.05
RAD2
Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
YHR139C-A 2.03 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR307C-A 2.01 Putative protein of unknown function
YHL036W 2.01
MUP3
Low affinity methionine permease, similar to Mup1p
YOL084W 1.98
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YEL010W 1.96 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL148C 1.94
SDH1
Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YPR169W-A 1.93 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps two other dubious ORFs: YPR170C and YPR170W-B
YJL020C 1.91
BBC1
Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches
YIL059C 1.91 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W
YJL213W 1.91 Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p
YMR034C 1.90 Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene
YKR067W 1.90
GPT2
Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis
YCR068W 1.89
ATG15
Lipase, required for intravacuolar lysis of autophagosomes; located in the endoplasmic reticulum membrane and targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway
YGL089C 1.87
MF(ALPHA)2
Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2
YPR005C 1.85
HAL1
Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p
YBL049W 1.84
MOH1
Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase
YKL163W 1.83
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YPL164C 1.81
MLH3
Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability
YOR011W-A 1.80 Putative protein of unknown function
YGR233C 1.78
PHO81
Cyclin-dependent kinase (CDK) inhibitor, regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p
YBL039W-B 1.75 Putative protein of unknown function
YOR347C 1.74
PYK2
Pyruvate kinase that appears to be modulated by phosphorylation; PYK2 transcription is repressed by glucose, and Pyk2p may be active under low glycolytic flux
YLR346C 1.74 Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene
YBR046C 1.72
ZTA1
Zeta-crystallin homolog, found in the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin, which has quinone oxidoreductase activity
YMR175W 1.71
SIP18
Protein of unknown function whose expression is induced by osmotic stress
YLR054C 1.71
OSW2
Protein of unknown function proposed to be involved in the assembly of the spore wall
YMR103C 1.70 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR303W 1.69
CPA1
Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader
YJR091C 1.69
JSN1
Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; overexpression suppresses a tub2-150 mutation and causes increased sensitivity to benomyl in wild-type cells
YAL061W 1.69
BDH2
Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; BDH2 is an essential gene
YKL161C 1.68 Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; associates with Rlm1p
YNL176C 1.66 Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p
YBR208C 1.64
DUR1,2
Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YPR201W 1.62
ARR3
Arsenite transporter of the plasma membrane, required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite
YKL016C 1.61
ATP7
Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YEL049W 1.60
PAU2
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YJL199C 1.60
MBB1
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies
YEL007W 1.60 Putative protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1)
YIR027C 1.59
DAL1
Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression
YDL124W 1.59 NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family
YIL107C 1.58
PFK26
6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, has negligible fructose-2,6-bisphosphatase activity, transcriptional regulation involves protein kinase A
YNL197C 1.57
WHI3
RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start
YJR150C 1.57
DAN1
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YFL019C 1.54 Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene
YHR101C 1.54
BIG1
Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan
YHR199C 1.53
AIM46
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YMR118C 1.52 Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene
YLR312C 1.52
QNQ1
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YNL094W 1.52
APP1
Protein of unknown function, interacts with Rvs161p and Rvs167p; computational analysis of protein-protein interactions in large-scale studies suggests a possible role in actin filament organization
YLR334C 1.51 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here
YDR114C 1.51 Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium
YER187W 1.50 Putative protein of unknown function; induced in respiratory-deficient cells
YGR110W 1.50 Putative protein of unknown function; transcription is increased in response to genotoxic stress; plays a role in restricting Ty1 transposition
YKL043W 1.48
PHD1
Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate
YJR160C 1.47
MPH3
Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph2p; encoded in a subtelomeric position in a region likely to have undergone duplication
YPL061W 1.47
ALD6
Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress
YBR128C 1.46
ATG14
Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I (with Vps34p, Vps15p, and Vps30p); Atg14p targets complex I to the pre-autophagosomal structure (PAS); required for localizing additional ATG proteins to the PAS
YBR054W 1.45
YRO2
Putative protein of unknown function; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p
YDR306C 1.45 F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain
YPR117W 1.44 Putative protein of unknown function
YMR169C 1.44
ALD3
Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose
YOR290C 1.43
SNF2
Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p
YPL271W 1.41
ATP15
Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YBR179C 1.41
FZO1
Mitochondrial integral membrane protein involved in mitochondrial fusion and maintenance of the mitochondrial genome; contains N-terminal GTPase domain
YLR375W 1.40
STP3
Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids
YKL087C 1.40
CYT2
Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
YLR080W 1.39
EMP46
Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
YJR095W 1.39
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YML116W-A 1.38 Putative protein of unknown function
YAL017W 1.38
PSK1
One of two (see also PSK2) PAS domain containing S/T protein kinases; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status
YMR084W 1.36 Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains
YKL124W 1.36
SSH4
Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases
YCL001W-B 1.35 Putative protein of unknown function; identified by homology
YOR192C 1.34
THI72
Transporter of thiamine or related compound; shares sequence similarity with Thi7p
YJL101C 1.34
GSH1
Gamma glutamylcysteine synthetase catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury
YIL017C 1.34
VID28
Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm
YBL101C 1.33
ECM21
Non-essential protein of unknown function; promoter contains several Gcn4p binding elements
YLR374C 1.33 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W
YGR053C 1.32 Putative protein of unknown function
YOR394W 1.32
PAU21
Hypothetical protein
YOR208W 1.31
PTP2
Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus
YOR192C-C 1.30 Putative protein of unknown function; identified by expression profiling and mass spectrometry
YDL182W 1.30
LYS20
Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys21p
YKL115C 1.29 Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1

Network of associatons between targets according to the STRING database.

First level regulatory network of CAD1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 15.5 GO:0015891 siderophore transport(GO:0015891)
1.9 3.8 GO:0072353 cellular age-dependent response to reactive oxygen species(GO:0072353)
1.8 10.8 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
1.8 5.3 GO:0042843 D-xylose catabolic process(GO:0042843)
1.7 5.1 GO:0015888 thiamine transport(GO:0015888)
1.5 4.6 GO:0043335 protein unfolding(GO:0043335)
1.3 1.3 GO:0001315 age-dependent response to reactive oxygen species(GO:0001315)
1.2 3.7 GO:0017006 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
1.2 3.6 GO:0019676 ammonia assimilation cycle(GO:0019676)
1.1 6.6 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
1.0 2.1 GO:0000736 double-strand break repair via single-strand annealing, removal of nonhomologous ends(GO:0000736)
1.0 3.1 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
1.0 2.1 GO:0000101 sulfur amino acid transport(GO:0000101) neutral amino acid transport(GO:0015804)
1.0 3.1 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
1.0 5.1 GO:0043954 cellular component maintenance(GO:0043954)
1.0 5.9 GO:0042407 cristae formation(GO:0042407)
0.9 2.7 GO:0046160 heme a biosynthetic process(GO:0006784) heme a metabolic process(GO:0046160)
0.9 2.7 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.9 1.7 GO:0071462 response to water(GO:0009415) cellular response to water stimulus(GO:0071462)
0.8 2.5 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.8 3.3 GO:0019627 urea metabolic process(GO:0019627)
0.8 3.9 GO:0051180 vitamin transport(GO:0051180)
0.8 2.3 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.8 2.3 GO:0071169 establishment of protein localization to chromosome(GO:0070199) establishment of protein localization to chromatin(GO:0071169)
0.7 2.9 GO:0006848 pyruvate transport(GO:0006848)
0.6 2.5 GO:0060195 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.6 1.9 GO:0036257 multivesicular body organization(GO:0036257)
0.6 3.1 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.6 3.0 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.6 4.7 GO:0000411 regulation of transcription by galactose(GO:0000409) positive regulation of transcription by galactose(GO:0000411)
0.6 1.7 GO:0044109 cellular alcohol catabolic process(GO:0044109)
0.5 3.3 GO:0000256 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256)
0.5 1.1 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.5 3.7 GO:0006855 drug transmembrane transport(GO:0006855)
0.5 1.6 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.5 1.0 GO:0061414 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
0.5 1.0 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.5 2.0 GO:0006740 NADPH regeneration(GO:0006740)
0.5 0.5 GO:0042743 hydrogen peroxide metabolic process(GO:0042743)
0.5 1.9 GO:0043901 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.5 1.9 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.5 1.4 GO:0015740 C4-dicarboxylate transport(GO:0015740)
0.4 0.4 GO:0042819 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.4 1.3 GO:0042542 response to hydrogen peroxide(GO:0042542)
0.4 1.3 GO:0000200 inactivation of MAPK activity involved in cell wall organization or biogenesis(GO:0000200) regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903137) negative regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903138) negative regulation of cell wall organization or biogenesis(GO:1903339)
0.4 1.7 GO:0051444 negative regulation of ligase activity(GO:0051352) negative regulation of ubiquitin-protein transferase activity(GO:0051444)
0.4 2.2 GO:0008053 mitochondrial fusion(GO:0008053)
0.4 10.3 GO:0006119 oxidative phosphorylation(GO:0006119)
0.4 0.8 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.4 2.8 GO:0061013 regulation of mRNA catabolic process(GO:0061013)
0.4 1.6 GO:0051654 establishment of mitochondrion localization(GO:0051654)
0.4 16.7 GO:0042244 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
0.4 0.8 GO:0000042 protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.4 1.2 GO:0006538 glutamate catabolic process(GO:0006538)
0.4 1.1 GO:0015847 putrescine transport(GO:0015847)
0.4 2.2 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.4 3.3 GO:0006077 (1->6)-beta-D-glucan metabolic process(GO:0006077)
0.4 1.1 GO:0032874 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.4 1.4 GO:0006598 polyamine catabolic process(GO:0006598)
0.4 1.1 GO:0046039 GTP biosynthetic process(GO:0006183) GTP metabolic process(GO:0046039)
0.4 9.3 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.4 0.7 GO:0090295 nitrogen catabolite repression of transcription(GO:0090295)
0.4 1.4 GO:0015893 drug transport(GO:0015893)
0.3 2.4 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.3 1.0 GO:0009106 lipoate metabolic process(GO:0009106) lipoate biosynthetic process(GO:0009107)
0.3 3.6 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.3 2.5 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.3 1.2 GO:0015793 glycerol transport(GO:0015793)
0.3 3.3 GO:0015758 glucose transport(GO:0015758)
0.3 2.7 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.3 2.7 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436) carbon catabolite activation of transcription(GO:0045991)
0.3 0.9 GO:0043200 response to amino acid(GO:0043200)
0.3 1.5 GO:0032102 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.3 2.6 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.3 2.0 GO:0000023 maltose metabolic process(GO:0000023)
0.3 0.6 GO:0042732 D-xylose metabolic process(GO:0042732)
0.3 1.7 GO:0007532 regulation of mating-type specific transcription, DNA-templated(GO:0007532)
0.3 0.8 GO:0071073 positive regulation of phospholipid biosynthetic process(GO:0071073) positive regulation of phospholipid metabolic process(GO:1903727)
0.3 1.1 GO:0051303 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.3 1.6 GO:0006085 acetyl-CoA biosynthetic process(GO:0006085)
0.3 2.9 GO:0006526 arginine biosynthetic process(GO:0006526)
0.3 1.0 GO:2000284 positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.2 6.5 GO:0008219 apoptotic process(GO:0006915) cell death(GO:0008219) programmed cell death(GO:0012501)
0.2 1.0 GO:0051865 protein autoubiquitination(GO:0051865)
0.2 1.5 GO:0010508 positive regulation of autophagy(GO:0010508)
0.2 0.7 GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000448)
0.2 2.6 GO:0006895 Golgi to endosome transport(GO:0006895)
0.2 0.9 GO:0070933 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.2 0.7 GO:0031335 regulation of sulfur amino acid metabolic process(GO:0031335)
0.2 3.6 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.2 4.5 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.2 1.3 GO:0006097 glyoxylate cycle(GO:0006097)
0.2 1.0 GO:0070096 mitochondrial outer membrane translocase complex assembly(GO:0070096)
0.2 1.0 GO:0033993 response to lipid(GO:0033993) response to oleic acid(GO:0034201) response to fatty acid(GO:0070542) cellular response to lipid(GO:0071396) cellular response to fatty acid(GO:0071398) cellular response to oleic acid(GO:0071400)
0.2 0.2 GO:0071168 protein localization to chromatin(GO:0071168)
0.2 1.7 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.2 0.9 GO:0006265 DNA topological change(GO:0006265)
0.2 0.6 GO:0007070 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070) regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021)
0.2 1.2 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.2 2.5 GO:1905037 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.2 2.5 GO:0006098 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.2 0.5 GO:0034395 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.2 1.0 GO:0015802 basic amino acid transport(GO:0015802)
0.2 1.9 GO:0071265 L-methionine biosynthetic process(GO:0071265)
0.2 0.8 GO:0003400 regulation of COPII vesicle coating(GO:0003400) regulation of vesicle targeting, to, from or within Golgi(GO:0048209) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.2 1.3 GO:0006865 amino acid transport(GO:0006865)
0.2 0.8 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.2 0.5 GO:0042710 biofilm formation(GO:0042710) negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
0.2 0.9 GO:0006279 premeiotic DNA replication(GO:0006279)
0.1 0.3 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.1 0.6 GO:0043112 receptor recycling(GO:0001881) protein import into peroxisome matrix, receptor recycling(GO:0016562) receptor metabolic process(GO:0043112)
0.1 0.6 GO:0034227 tRNA thio-modification(GO:0034227)
0.1 1.0 GO:0051322 anaphase(GO:0051322)
0.1 1.8 GO:0046854 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.1 0.7 GO:0007534 gene conversion at mating-type locus(GO:0007534)
0.1 1.0 GO:0051177 meiotic sister chromatid cohesion(GO:0051177)
0.1 0.3 GO:0005985 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.1 2.1 GO:0007118 budding cell apical bud growth(GO:0007118)
0.1 0.6 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.1 1.1 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 1.1 GO:0040001 establishment of mitotic spindle orientation(GO:0000132) establishment of mitotic spindle localization(GO:0040001) establishment of spindle orientation(GO:0051294)
0.1 0.6 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.1 0.6 GO:0045144 meiosis II(GO:0007135) meiotic sister chromatid segregation(GO:0045144)
0.1 0.9 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.1 0.4 GO:0000078 obsolete cytokinesis after mitosis checkpoint(GO:0000078)
0.1 0.9 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491)
0.1 0.2 GO:0016578 histone deubiquitination(GO:0016578)
0.1 0.5 GO:0071406 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
0.1 0.3 GO:0006824 cobalt ion transport(GO:0006824)
0.1 0.5 GO:0051569 positive regulation of histone methylation(GO:0031062) regulation of histone H3-K4 methylation(GO:0051569)
0.1 0.8 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 0.4 GO:0007234 osmosensory signaling via phosphorelay pathway(GO:0007234)
0.1 1.2 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.1 1.3 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.1 0.3 GO:0006089 lactate metabolic process(GO:0006089)
0.1 0.7 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.1 1.8 GO:0006298 mismatch repair(GO:0006298)
0.1 0.6 GO:0070873 regulation of glycogen biosynthetic process(GO:0005979) regulation of glycogen metabolic process(GO:0070873)
0.1 0.4 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.1 1.9 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.1 0.3 GO:0072530 cytosine transport(GO:0015856) purine-containing compound transmembrane transport(GO:0072530)
0.1 0.3 GO:0031297 replication fork processing(GO:0031297)
0.1 0.4 GO:0030042 actin filament depolymerization(GO:0030042)
0.1 0.1 GO:1900544 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.1 0.6 GO:0006829 zinc II ion transport(GO:0006829)
0.1 1.1 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.1 1.1 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.1 0.7 GO:0070987 error-free translesion synthesis(GO:0070987)
0.1 0.6 GO:0018345 protein palmitoylation(GO:0018345)
0.1 0.5 GO:0000266 mitochondrial fission(GO:0000266)
0.1 0.6 GO:0034063 stress granule assembly(GO:0034063)
0.1 0.3 GO:0006835 dicarboxylic acid transport(GO:0006835)
0.1 0.3 GO:0001927 exocyst assembly(GO:0001927)
0.1 1.3 GO:0006312 mitotic recombination(GO:0006312)
0.1 0.6 GO:0000755 cytogamy(GO:0000755)
0.1 0.9 GO:0043486 histone exchange(GO:0043486)
0.1 0.6 GO:0034085 establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087)
0.1 0.3 GO:0046688 response to copper ion(GO:0046688)
0.1 0.9 GO:0006513 protein monoubiquitination(GO:0006513)
0.1 1.0 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.1 0.3 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.1 0.4 GO:0072348 sulfur compound transport(GO:0072348)
0.1 0.7 GO:0016925 protein sumoylation(GO:0016925)
0.1 0.2 GO:0072396 cellular response to biotic stimulus(GO:0071216) response to cell cycle checkpoint signaling(GO:0072396) response to mitotic cell cycle checkpoint signaling(GO:0072414) response to spindle checkpoint signaling(GO:0072417) response to mitotic spindle checkpoint signaling(GO:0072476) response to mitotic cell cycle spindle assembly checkpoint signaling(GO:0072479) response to spindle assembly checkpoint signaling(GO:0072485) negative regulation of protein import into nucleus during spindle assembly checkpoint(GO:1901925)
0.1 2.5 GO:0006631 fatty acid metabolic process(GO:0006631)
0.1 0.2 GO:0060237 regulation of fungal-type cell wall organization(GO:0060237)
0.1 0.7 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.6 GO:0044396 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.0 0.3 GO:0010388 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.0 0.4 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.0 0.7 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.0 0.1 GO:0034503 protein localization to nucleolar rDNA repeats(GO:0034503)
0.0 0.1 GO:0016577 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.0 0.6 GO:0001300 chronological cell aging(GO:0001300)
0.0 0.2 GO:0051053 negative regulation of DNA metabolic process(GO:0051053)
0.0 0.1 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 0.6 GO:0008361 regulation of cell size(GO:0008361)
0.0 0.6 GO:0001558 regulation of cell growth(GO:0001558)
0.0 0.2 GO:0070124 mitochondrial translational initiation(GO:0070124)
0.0 0.1 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.0 0.2 GO:0006452 translational frameshifting(GO:0006452)
0.0 0.2 GO:0000103 sulfate assimilation(GO:0000103)
0.0 0.3 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.0 0.1 GO:0048279 vesicle fusion with endoplasmic reticulum(GO:0048279)
0.0 0.2 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.2 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.0 0.2 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.0 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.1 GO:0032205 negative regulation of telomere maintenance(GO:0032205) negative regulation of homeostatic process(GO:0032845)
0.0 0.1 GO:0070676 intralumenal vesicle formation(GO:0070676)
0.0 1.4 GO:0006310 DNA recombination(GO:0006310)
0.0 0.1 GO:0051098 regulation of binding(GO:0051098)
0.0 0.2 GO:0031167 rRNA methylation(GO:0031167)
0.0 0.2 GO:0045005 DNA-dependent DNA replication maintenance of fidelity(GO:0045005)
0.0 0.3 GO:0032005 pheromone-dependent signal transduction involved in conjugation with cellular fusion(GO:0000750) signal transduction involved in conjugation with cellular fusion(GO:0032005)
0.0 0.2 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.0 0.2 GO:0015749 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.0 0.0 GO:0018206 N-terminal peptidyl-methionine acetylation(GO:0017196) peptidyl-methionine modification(GO:0018206)
0.0 0.0 GO:0046461 triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)
0.0 0.1 GO:0043461 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615) proton-transporting ATP synthase complex assembly(GO:0043461)
0.0 0.2 GO:0000002 mitochondrial genome maintenance(GO:0000002)
0.0 0.0 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 0.1 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.3 GO:0097042 extrinsic component of fungal-type vacuolar membrane(GO:0097042)
0.8 7.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.8 2.4 GO:0032807 DNA ligase IV complex(GO:0032807)
0.7 4.2 GO:0033263 CORVET complex(GO:0033263)
0.7 2.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.6 8.4 GO:0005619 ascospore wall(GO:0005619)
0.6 1.9 GO:0032585 multivesicular body membrane(GO:0032585)
0.6 2.3 GO:0032116 SMC loading complex(GO:0032116)
0.5 3.4 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.5 1.4 GO:0005756 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
0.5 2.3 GO:0032221 Rpd3S complex(GO:0032221)
0.4 22.2 GO:0031225 anchored component of membrane(GO:0031225)
0.4 1.9 GO:0045273 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.4 0.8 GO:0030061 mitochondrial crista(GO:0030061)
0.4 1.5 GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271)
0.3 2.9 GO:0005770 late endosome(GO:0005770)
0.3 0.9 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.3 2.7 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.3 1.2 GO:0005825 half bridge of spindle pole body(GO:0005825)
0.3 2.1 GO:0034657 GID complex(GO:0034657)
0.3 4.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.3 0.5 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.3 0.8 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.3 2.3 GO:0000795 synaptonemal complex(GO:0000795)
0.3 1.3 GO:0072379 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.2 0.7 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.2 0.9 GO:0031901 early endosome membrane(GO:0031901)
0.2 0.8 GO:0001400 mating projection base(GO:0001400)
0.2 0.8 GO:0033551 monopolin complex(GO:0033551)
0.2 0.6 GO:0032177 split septin rings(GO:0032176) cellular bud neck split septin rings(GO:0032177)
0.2 1.2 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.2 0.4 GO:0000306 extrinsic component of vacuolar membrane(GO:0000306)
0.2 4.2 GO:0005628 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.2 0.7 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.2 0.6 GO:0033100 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.2 1.1 GO:0034967 Set3 complex(GO:0034967)
0.2 2.0 GO:0070469 respiratory chain(GO:0070469)
0.1 0.3 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.1 0.3 GO:0032389 MutLalpha complex(GO:0032389)
0.1 0.7 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.1 0.9 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.1 2.1 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.1 1.0 GO:0000235 astral microtubule(GO:0000235) aster(GO:0005818)
0.1 1.3 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 0.6 GO:0038201 TOR complex(GO:0038201)
0.1 6.9 GO:0044440 endosome membrane(GO:0010008) endosomal part(GO:0044440)
0.1 1.1 GO:0098552 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.1 0.3 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.1 0.9 GO:0005656 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.1 0.4 GO:0032865 ERMES complex(GO:0032865) ER-mitochondrion membrane contact site(GO:0044233)
0.1 0.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 1.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 0.9 GO:0005686 U2 snRNP(GO:0005686)
0.1 12.0 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 1.7 GO:0016592 mediator complex(GO:0016592)
0.1 0.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 3.1 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 2.6 GO:0030479 actin cortical patch(GO:0030479) endocytic patch(GO:0061645)
0.1 0.1 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.1 0.2 GO:0071819 DUBm complex(GO:0071819)
0.1 0.2 GO:0035649 Nrd1 complex(GO:0035649)
0.1 2.4 GO:0005934 cellular bud tip(GO:0005934)
0.1 2.8 GO:0000131 incipient cellular bud site(GO:0000131)
0.0 0.3 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.2 GO:0000799 condensin complex(GO:0000796) nuclear condensin complex(GO:0000799)
0.0 0.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.3 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.4 GO:0090544 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.0 0.6 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.2 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.3 GO:0071007 U2-type catalytic step 2 spliceosome(GO:0071007) catalytic step 2 spliceosome(GO:0071013)
0.0 0.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.1 GO:0005871 kinesin complex(GO:0005871)
0.0 0.3 GO:0097526 U4/U6 x U5 tri-snRNP complex(GO:0046540) spliceosomal tri-snRNP complex(GO:0097526)
0.0 1.3 GO:0005643 nuclear pore(GO:0005643)
0.0 0.5 GO:0097346 INO80-type complex(GO:0097346)
0.0 0.8 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.0 GO:0070209 ASTRA complex(GO:0070209)
0.0 0.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.1 GO:0000500 RNA polymerase I upstream activating factor complex(GO:0000500)
0.0 0.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 11.2 GO:0005537 mannose binding(GO:0005537)
2.4 9.7 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
1.9 7.5 GO:0015603 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
1.5 1.5 GO:0042947 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
1.3 5.3 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
1.0 15.3 GO:0015293 symporter activity(GO:0015293)
0.9 2.8 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.9 3.6 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.9 9.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.8 3.4 GO:0045118 azole transporter activity(GO:0045118)
0.8 4.1 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.8 4.6 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.7 2.2 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.7 2.1 GO:0016208 AMP binding(GO:0016208) acid-ammonia (or amide) ligase activity(GO:0016880)
0.7 5.4 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.7 2.0 GO:0003840 gamma-glutamyltransferase activity(GO:0003840)
0.7 3.3 GO:0016783 sulfurtransferase activity(GO:0016783)
0.7 12.6 GO:0015297 antiporter activity(GO:0015297)
0.6 4.3 GO:0004364 glutathione transferase activity(GO:0004364)
0.6 2.4 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.6 2.4 GO:0000772 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.6 1.8 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.6 0.6 GO:0016597 amino acid binding(GO:0016597)
0.5 3.3 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.5 1.1 GO:0001097 RNA polymerase II basal transcription factor binding(GO:0001091) TFIIH-class transcription factor binding(GO:0001097)
0.5 1.6 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.5 1.5 GO:0016872 intramolecular lyase activity(GO:0016872)
0.5 3.0 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.5 1.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.5 0.5 GO:0015101 organic cation transmembrane transporter activity(GO:0015101)
0.5 2.7 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.4 2.7 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.4 3.0 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.4 4.1 GO:0043495 protein anchor(GO:0043495)
0.4 2.4 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.4 1.9 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.4 1.9 GO:0017022 myosin binding(GO:0017022)
0.4 1.5 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.4 1.9 GO:0004806 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.4 2.2 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.4 12.4 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.3 1.7 GO:0004075 biotin carboxylase activity(GO:0004075)
0.3 4.0 GO:0022838 substrate-specific channel activity(GO:0022838)
0.3 0.6 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.3 3.5 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.3 0.8 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.2 2.6 GO:0030983 mismatched DNA binding(GO:0030983)
0.2 0.9 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.2 0.7 GO:0004866 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
0.2 2.7 GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.2 4.4 GO:0016209 antioxidant activity(GO:0016209)
0.2 0.6 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.2 0.6 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.2 0.6 GO:0070569 uridylyltransferase activity(GO:0070569)
0.2 0.9 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.2 0.9 GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)(GO:0097372)
0.2 1.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 0.9 GO:0008198 ferrous iron binding(GO:0008198)
0.2 0.2 GO:0016878 CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
0.2 2.2 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.2 0.3 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.2 1.6 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.1 9.9 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
0.1 4.3 GO:0008234 cysteine-type peptidase activity(GO:0008234)
0.1 0.7 GO:0019789 SUMO transferase activity(GO:0019789)
0.1 0.4 GO:0019212 protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
0.1 1.7 GO:0005199 structural constituent of cell wall(GO:0005199)
0.1 1.5 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 3.4 GO:0061733 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.1 0.5 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 0.4 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.1 0.5 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.1 0.5 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.1 0.6 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.1 0.5 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 0.9 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 3.5 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.1 1.2 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 0.4 GO:0000156 phosphorelay response regulator activity(GO:0000156)
0.1 0.3 GO:0016417 S-acyltransferase activity(GO:0016417)
0.1 0.3 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.1 1.2 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.1 0.1 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 0.7 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 1.3 GO:0008236 serine-type peptidase activity(GO:0008236)
0.1 0.3 GO:0004458 D-lactate dehydrogenase (cytochrome) activity(GO:0004458)
0.1 0.7 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.1 0.6 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.1 1.4 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 1.0 GO:0042803 protein homodimerization activity(GO:0042803)
0.1 0.9 GO:0015036 protein disulfide oxidoreductase activity(GO:0015035) disulfide oxidoreductase activity(GO:0015036)
0.1 0.3 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.1 1.3 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.1 7.7 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.1 0.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.4 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
0.1 0.7 GO:0003777 microtubule motor activity(GO:0003777)
0.1 0.1 GO:0015085 calcium ion transmembrane transporter activity(GO:0015085)
0.1 1.0 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 0.4 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.1 1.2 GO:0019901 protein kinase binding(GO:0019901)
0.1 3.4 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.1 0.4 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.5 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 0.1 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.0 0.0 GO:0017171 serine hydrolase activity(GO:0017171)
0.0 0.1 GO:0033549 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.0 0.4 GO:0000293 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.0 0.2 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0 0.2 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 3.1 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.5 GO:0009055 electron carrier activity(GO:0009055)
0.0 0.8 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 1.1 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.2 GO:0008171 O-methyltransferase activity(GO:0008171)
0.0 0.1 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity(GO:0034596) phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.0 0.4 GO:0045182 translation regulator activity(GO:0045182)
0.0 0.2 GO:0001003 RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003) transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting(GO:0001004) transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIB recruiting(GO:0001005) transcription factor activity, RNA polymerase III type 2 promoter sequence-specific binding, TFIIIB recruiting(GO:0001008) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034)
0.0 0.2 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 0.1 GO:0001099 RNA polymerase II core binding(GO:0000993) basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0 0.6 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.3 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.0 0.3 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.1 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.2 GO:0031072 heat shock protein binding(GO:0031072)
0.0 0.3 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.5 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.2 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.2 GO:0019904 protein domain specific binding(GO:0019904)
0.0 0.1 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.2 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.2 GO:0003774 motor activity(GO:0003774)
0.0 0.1 GO:0001163 RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) transcription factor activity, RNA polymerase I upstream control element sequence-specific binding(GO:0001168)
0.0 0.2 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 0.1 GO:0000149 SNARE binding(GO:0000149)
0.0 0.1 GO:0004407 histone deacetylase activity(GO:0004407) protein deacetylase activity(GO:0033558)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.5 PID FOXO PATHWAY FoxO family signaling
0.6 1.9 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.4 1.6 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.4 0.4 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.4 0.7 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.3 0.6 PID IL4 2PATHWAY IL4-mediated signaling events
0.2 0.5 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.1 0.4 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 0.4 PID CMYB PATHWAY C-MYB transcription factor network
0.1 124.7 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 0.2 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 0.4 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.3 2.4 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.3 2.5 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.2 1.2 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.2 0.5 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 0.4 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 0.3 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 124.7 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 0.7 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 0.6 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.3 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.1 REACTOME TRANSCRIPTION Genes involved in Transcription
0.0 0.2 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation